Document RJB6X6N0eMwYNdQQ44q5ZxdLB

e. i. du ?c:? ce devours & company * Incorporated ORGANIC CHEMICALS DEPARTMENT Chambers Uorks tt: *7cn n^Tniniiun?i L1 K: * t ' * ' ' ' ' A. L. Linch, Medical Division T.-J. R. Stephens, Aomin. Bldg. H. I. Stryker, Admin. Bldg. January 17/ 1959 R. A. Brooko Crches, V/iLta. TOXIC MATERIALS WITH DELAYED REACTIONS In response to your memorandum of January 2, 19'oS* I am submitting JO copieo of provisional lists of toxic materials manufactured or consumed at. the Chambers Works,- which have delayed physiological reactions. The tabulation is dLvided. into two sections, covering those materials v/hose effects are felt v;ithin 2^ hours, and these whose effects may not be apparent for extended periods of time. Toxic materials . which set without delay have been excluded. These lists were prepared in cooperation with A. L. Linch, Medical Divi sion, whose guidance and assistance are gratefully acknow ledged. I regard these licts as provisional for two reasons. First, they were compiled in haste; while they cover all of our critically hazardous materials, I have not audited their completeness. Additional candidates are still being sug gested by our operating areas. Second, there are marginal items which require further consideration before they can be classified. For instance, the relative hazards of benzidine, dlanieidine end tolidine as carcinogens are debatable; and 9oxe aromatic amines cause cyanosis at such a moderate rate that It is hard to cay v;hether their effects .are delayed or not. I plan to issue final lists in about two months' time. 168 in. N. M. Bigelow Documentation Division Process Department 1 NMB/fpd A * r* *> DUP 0901190 n =? n o q SC-DP-02575 CLASS I The Tallowing chemicals cause little or no physiological response at the time of exposure, but.cause acute effects several hours luter. material Mode of attack and expooure Benzene -Mf- Anemlogenic; by sk'.n contact or inhalation of vapora Bromine - /W .* i Respiratory syGtem (pulmonary edema) and skin; by inhalation of vapora or skin contact Carbonyl fluoride w^/*' Reopiratory system (pulmonary edema); by inhalation "Ceresan*1 mercurial ^ i seed disinfectants Systemic poison and skin Irritant (vesicant); by inhalation of dust or skin contact Chlorine - Respiratory system (pulmonary edema); by inhalation of vapora ' D'.methylacetamide *coo OOU3 D methylformamlde Systemic poison; by skin contact or inhalation of vapors Systemic poison; by skin contact or inhalation of vapors VO Dimethyl sulfate Respiratory system; by inhalation of vapors, and to skin by contact Dinitrobenzene - /V/t/f Cyanogenic; by contact with skin or Inhalation of du3t n 0 0 0 *Mg. particulate matter per cubic meter of sir Threshold Limit Vcluo (1966) 25 ppoi 0.1 ppm 1 ppn 10 ppm 1 ppm 1i ing/i-a13;> Class I Page 2 Material Fluorocarbons, un3aturated ' 2>l^ Hexafluoropropylene j/**' Hydrofluoric acid (aqueous solutions) Lead; its oxides and Balts^c DUP 0901192 MDI . . Mercury, its oxides and salts Methylene bi3(2-chloro-~^ aniline) (MOCA) Methylene bio(^-phenyl- / Isocyanate) (MDI) MOCA f Nitroanllineo (all isomers) . jjj. - *'*'*** Nitrobenzene(v_t ><r ji s Nitrogen oxides o o J1 Mode of attack and exposure Respiratory syctera (pulmonary edetr.u); inhalation of vapors Respiratory system; by inhalation of vapora Skin; by contact Systemic; by inhalation of duotB and vapors See Methylene bi3(b-phenyllaocyanate) Systemic; by akin contact or inhalation of du3ta and vapora Carcinogenic (questioned); by inhalation of vapora or akin contact Respiratory sensitization; by Inhalation of vapors or akin contact See Methylene bis(2-ehloro3niline) Cyanogenic; by akin contuct or inhalation of vapora . Cyanogenic and anetniogenic; by akin contact or inhalation of vapora Respiratory system; by inhalation of vapora ' Thrcohold Limit Value (1963) 0.2 mg/i'l3* 0.1 mg/li > 0.02 ppm 1 ppm 1 ppm 5 PpCl ~ r. 4' AY* i V* Class I Page 3 Material Mode of attack. and exposure Nitrosodimethylanillne Skin; by contact Mltrotoluenes / Cyanogealc; by skin contact or inhalation of vapors Pentschlorophenol Skin (oenaitizer); by contact Perfluorolaobutylene . Respiratory system (pulmonary edema); by inhalation of vapors or akin contact Phenol Skin (corrosive); by contact o-Phenylenedlamine . Skin (sensitizer); by contact p-Phenylenediamine Skin (oensitizer); by contact Phosgene. ' RespLratory system (pulmonary edema); by inhalation of vapors DUP 0901193 "Semeoan" mercurial seed disinfectants Sulfur dioxide Systemic and 3kin (vesicant); by contact or inhalation of dust Respiratory system (hazardous to asthmatics); by inhalation "Teflon", combustion products Respiratory system (pulmonary edema) by inhalation of fumes or amoke (welding hazard) o Tetraethyl lead Syotcmic; by skin contact or J\ o Inhalation of vapors Ci D I. h Mg. of particulate material per cubic meter of air Three* no Id Lli;.lt 5 ppm 0.5 mg/h 5 ppm 0.1 mg/H 0.1 ppm 5 ppm 0.075 m", :iana I Page 4 Material Tetrafluoroethylene Tetramethyl lead Thioglycollle acid .(aqueoue solutions) Toluenediisocyanate Tri-o-cresyl phosphate Mode of attack and exposure Respiratory system; by inhalation of vapors Systemic; by skin contact or Inhalation of vaporG SkLn (corrosive); by contact Respiratory (sensitizer) and syotemic; by contact or inhalation of vapors Systemic (paralysis); by contact Threshold Limit Values (l^ub sf 3.075 &2.A-?* 3.02 ppm 3.1 oca o VO o vO i Mg. of particulate mutcrlal per cubic meter of ulr o e u a ti CLASS IX The following chemicals cause physiological responses which may be delayed for extended periods. Material Mode of attack and exposure Aminobipheny1 Carcinogenicj by skin contact Asbestos (dust) Ccrcinogenlc; by inhalation Benzidine Carcinogenic; by skin contact Cadmium, lta oxides and salts . Carcinogenic ; by inhalation of dust or vapors (welding hazard) . Carbon tetrachloride SyBteraic; by inhalation of vapors Chloroform Chromium; its oxides * and salts Systemic; by inhalation of vapors . Carcinogenic; by inhalation of dust Or vapors Dlcnisidine Carcinogenic; by skin contuct Diazomethane . Carcinogenic; by inhalation of vapors Beta-naphthylamlne Carcinogenic; by okin contact nitronnphthalene crudes and eutectics Carcinogenic by reason of its content of beta-isomer; by okin contact or inhalation of dust DUP 0901195 Propone aultone _ Carcinogenic; by skin contact or inhalation ox- vopor3 Propiolactone ! Carcinogenic; by okin contact or inhalation of vnporo o Toltdine n Vanedium, its oxides and Carcinogenic; by skin contact SyBteraic; by Inhalation of dusts 0 ualto O ,,f,, mntprlnl per cubic meter of nlr Threshold Limit Values (196S) 3<t 5 mg/H 0.2 mg/ii 10 ppm 50 ppm 3 ** 0.5 mg/M 0.2 ppm 0.5 * ft \ HEALTH 1 CHEMICAL CONTROL SCREEN1NC ' CUaobera Work* Conteroctlon/iltdlctl ytS"r^Q hr*** P,k` -i------- -r CIICMICALS i Chloride IIC1, TCI, Uenzoyl Clilorlda, Acetyl Chloride) oholt (CH-,. CCLi( CHCLn) (Alcohol*) l)i-NaphthyUalnc (AN) noazotoluene onlt line ftldlne } eartoa x (AAT) izanthrone ttene izyltrlphenyl Photpboalua 'hlorlde (BTPPC) (-Cliloromerhyl Ether (BCME) tvl Alcohol rbon Oieulflde rbon Monoxide rbon Tetrtchlorlda (CO) *4 n. PU 0H u'i A ft* u Sft k4 Ma ft. H -O *4/ ft X n - ft C HI Vu* fct* 4 M 1* 1u* a o 1o -ft "O %V H C . < * n4 n Tuaxx xxxxx "\HXfX xxxxx 'XXXXX XXXXX xxxxx xxxxx xxxxx xxxxx xxxxx xxxxx o * o It O m mr nu O 4 u *u : O *-* O -* m X 4' u ri At o . P ft* c -i o s: *> o r. x X o Tnmnr xxxxxx nxxxx XXXXXX xxwnar xxxxxx imxx" xxxxxx xxxxxx xxxxxx xxxxxx xxxxxx VI :i o i' 4 7. aO xxxxx xxxxx s 1. >ft** f: 4r o o ft 4 > > 1 0- p o * u n. ft tI-4* u `A o eC ft* r. 4 aO pft CO o> o Xxxxx xxxxx xxxxx xxxxx JODOOT XXXXX 0 -s It. r ft v oX ft *t * s O 34 p ft o in *4 V i: * W1 V) t-< (Ni racn xxxxx xxxxx xxxxx TOTOT xxxxx xxxxx xxxxx xxxxx xxxxx XXXXXX xxxxxx WKX mtr xxxxx mn xxxxx xxxxx xxxxx xxxxx xxxxx xxxxx xxxxx xxxxx xxxxx xxxxx xxxxx xxxxx xxxxx xxxxx aXXXX xxxxx xxxxx xxxxx XXXXXX xxxxxx ft) 11 o fl>t sO ft) *O v r. o ** rt o n i V tx v> .* o 4 ti V e ft. ft O (A r: -< u V lhJ \, i i a n r <:t hi k. l ifPIJ R. 1/ A 10 U M *>* t --rq ur r~ mr----- fil, W , li'*l NO. .i rniih% A'IMS ii/i) .< III It M K. I 1 i.tM \r=-- 11 - iw (MS XXXXXX xxxxxx t/rjr -ttt: HIP.il 1 CT (HR 1 UP, L> A TiTvT I'lMS., iii "ftlO 1** (ICTlIO G*D0 ioO o 0 VoO\ D / , f> nf/*>e? WEALTH A CHEMICAL CONTROL SCREENING ' Chaahera Uork* Con*truetlon/Hedleal Rai* 2 CHEMICALS rdnojtenf. All lor In* Chloroaaino Toluene (Cb) (5-CAT) loro fora roMtei anosla Producer*. All (Anlllne/Nltrofcenzene Derivatives) ehloroantllne (Chloroaaine*) thyl Acet**id tod Olaetbyl forMoldc (OCA) (I3IIAC 4 (DHF) ethyl aniline (DMA) ethyl Carbaaoyl Chloride (DMCC) ethyl Sullata ' (DHS) nltrotoluene ovane natoaers/llyleno Area (Isocyanates) tiylcne Dlbronlde hylene Dlchlorlda hylene Thiourea (DNT) (Ofi) (EDC) (HA-22) a# * ou O VI V* U <H UM %a hna Hc 4*. *4 .n * V r U M) ro a(J X hi II w14. IU *1o rt --ot "(4 o >\ La * r M if u m vV4 c v4 <4 ha ha AS Q. O *ifi "oO V % h. o u u <: o O j.' -4 *i a! *4 iJf c *- o * *- u c >. ii m X 4* hi *) o > if O 4 '1 u u II aLt. -t , A ' if V > M > M o (. r> o ' if o ' K- 1 "1 . - o iiii n V u A vo if ) rr* tn If) t-< nn IO /*> co o> o r* Ksnuoi XX XXX XKXX> xxxx> XXXX1 xxxxx xxxxx xxxxx , xxxxxxx xxxxx xxxxx \AXXX xxxxx xxxxx xxxxx xxxxx xxxxx XXXX). xxxx* xxxxx xxxxx xxxxxxx xxxxxxx xxxxxxx xxxxx xxxxxxx xxxxxxx xxxxx iJUUX <xxxx xxxxxxx xxxxxxx XXXXa xxxxxxx xxxxx xxxxxxx TOrsrm BOTS' mxr xxxxxxx xxxxxxx xxxxx nxw xxxxx xxxxx xxxxx icmx xxxxx XXXXX xxxxx XaaXaaX xxxxx xxxxxxx XXXXXXX xxxxxxx xxxxxxx xxxxxxx kuixx xxxxx mss xxxxx XXXXXXX xxxxxxx iHHf xxxxxxx itmm xxxxxxx xxxxx xxxxxxx xxxxx xxxxxxx *vXXV>T xxxxx manor xxxxx UXKX 5<XXX ' \k/k xxxx xxxxx xxxxx xXxxx' xXXXX xxxxx VaXXX xxxxx' xxxxx xxxxx XXXXX xxxxx .\XXXX xxxxx Si.\.VL \a\Xail_ JLLUX XXXXX (XXXX xxxxxxx xxxxx vXXXX xxxxxxx to .. o W V A <>1 * V. mi o *-v 1' lA o ft rri v .1 *4 i V O i/i -1 XAXXaXX xxxxxxx xxxxxxx xxxxxxx < u *coo . <oo> u> . ''/ < I ! HEALTH A CHEMICAL CONTROL SCKEEMINC Chaabera Work* . Conatructlon/Medlcal Pat* 3 CHEMICALS maldehyde afluoroaceton* (UFA) aaethylphoaplioraalde iraxln* (and Hydra*ina Irate) (IHPA) ' Irofluortc Acid dll'') Iroten Chloride (IICL) icvonatea (TDI. Hvlene. MDI) .d (Pb) rcury 01k) (a Toluene Dlaalne (HTO) . thyl Alcohol thyl AcryUte thvl Chloride (C1UCL) thyl Ethyl Ketone (HEK) thyl Methacrylate 4'-tlethylene Bin (1*1) `thylene blt-Olunlllnt (MDA) wt 3U O i *1 4O1 M* lM U MC p4, #-4 *H1 41 3C * 14 U *t c yi n 6 1* u tx o H4/ *OU z. <s n u /) 0o c 14) >0 o flfl V < C0 ."*v -4 * i: 4 u o i 0 4/ Hn O c 4/ M x: p- *A *n o l< 4) z XXXXX XXXXX XXX X) XXJOO xxxxxx XXXXXX XXXXXX XXXXXX xxxxxxx xxxxx xxxxxxx xxxxx xxxxxxx xxxxx xxxxxxx xxxxx ,XXXXX XXXCXX . xxxxxx xxxxx xxxxxx xxxxx xxxxxx XXXXXX icmx xxxxx xxxxx xxxxx 41 -x 1.. t< iV i: <v *1 o n <u A ;i *4 U ? o -f La T* u 4l K U) : 41 oo i l\ CO O' o XaXX* XXXaa .\AXXX xxxxx xxxxx xxxxx xxxxx aXXXX XXXXa XaaaXaX xxxxx xxxxx xxxxx xxxaxxx xxxxx xxxxx xxxxxxx xxxxx xxxxx xxxxxxx xxxxx xxx.o xxxxx xxxxx XXXXX xxxxx XX/Xa xxxxx VjTxVx" XXXXX .xxxxx Xxxaa xxxxx xxxxx TXXIV xxxxx *X^aX XXXXX xxxxx xxxxx J V u 4) 1 * 01* l.AV1 iV--a) rv. (1 4) . ; >: I; w*1 o n V I/I l .o < Ml V. < 1 O- vVsi 4 41 3 V u 41 AAAAAA/ XXXXXXX ~X7TaTXT xxxxxxx XXaaaX/ XXXXXX) XXXX) XXXX) XXXX) uxo XaXa * xxxx> 4, KXX.\X xxxxx xxxxx xxxxx o *c0 Zo *s J Z) l> 00 / -- ' HEAL ill L CHEMICAL CONTROL SCREENlNC Chamber* Work* Con*trueclon/Htdleal Pag* It CHEMICALS ilchler*# Kecon* llcrobenzene Hcronaphthal<n Ucrogen Oxide* irtho-Nltrochlorobenrene rtho Phenylenedlaalne >rtta Toluldtne -HItrobenty1 Brold *r-Cliloroaolilnc r*-NUroanlllne mre-PlienylenctHnntlne ' henyl Cylcldyl Ether (NB) (NW) <NOv) (ONCB) (0P0) (o-T) (PNBQ) (l*CA) (PHAN) (PPO) (PCE) `hoagene illlci Duet Sulfur Dioxide Sulfuric Acid Mist (SO?) a w DU O V< > u ul UM VVi it 32 H cA * IX O Cl x HN nmer xxxxx XXX XX xxxxx xmr xxxxx noonr xxxxx HOT! XXXXX * ar Ml V Cl c --- *H W 1. A* U uo *u 35 r> *0 si o c: O 'i ro j? O a >4 *\I It o * 0 .V *1 i: 'rsrrarxr xxxxxx> XXXKX\> xxxxxx> xxxxxx> XXXXXXX XXXXXXX xxxxxx> XXXXXX) xxxxxx> *TTTOxr> xxxxxx> K XXXxXX KXXXXX> Tynxw XXXXXX) trniii XXXXXX) o u o ;i 4V c *- o V Z J Cl cC:l >*) X Ae w : o i: V X A o ~XXXXa XXXXX Nt. O -J ft u ps. i, 0 > "1- V. V n4 it Ko CO O' XXTaT XXXXX r.* t: l. :> r f: u o o -* XXXXa xxxxx XXXXX XXXXX xxKivA , XXXXp. XXXXa TOnnr XXXXX XXXXX Kaaa.n xxxxx XXaaa XXXXX itcone xxxxx XXXXp. xxxx aXXXX xxxxx xxxxx xxxxx XX>A* .sw xxxx> xxxx.* XXXXp XXXX* .. XXXX a \XAaX xxxxxxxxxx /J . (a. 0* C o . u o > V U a v i* * * m i/1 H M XXXAXJcX xxxxxxx aXXAXXA N.V XXXXX Xxaa\aX xxxxxxx 0 1p i: o i Cl 'J V o *i XXaaXXX XXXXXXX Di *\ CJ /T -- -- -- -- DUP -J o VO -H o A t-* M ^i VO I) VO j / UEAlTh 4 CHEMICAL CONTROL SCREENING ' Chabera Uorka Conatructlon/Hcdlcal Ml W WoM TUuM* wU *Mr*t c- f*e X> V X s nM * O. o <uH v4c4* LU. wO 1o -- rj X T3 *0 0 <1 rn1 m 0) t M o &4 UC o --o 4 X U u o J c a- O A*-* x1/ d 42 >/> X P- k3rt o> 1V) X lt-<v o c o H -J 1. Ik H VV. u PC k m r. V> . i o <V4 a t*> o >A 1* 1/ k. <. tOi ' .TI 3 \j O O AAi -1*/1 'HI (* -rt V *v1 j:/ *4 O 4 VCIk o vt r. *v Mi k O VV) CHEMICALS ' Nn M r-s. 00 cr o r*. si vr rnt C-12 etrachloroazobenzcna) Luanedllaocyanate lchlorocthylcna (TLC-12) (TDI) (TCE) XXXXX xxxxx TOXXX xxx.xx AXXXXX> XXXXXX.' XXXXX XXXXX mmz" Tiro Yxxxk a aXXX nym xxxxxxx xxxxx xxxxx XXXXX xxxxx -------------- XXXXXAX xxxxxxx = - . *coo yoo o fo o o A V V L> t i> .