Document RJ3k6XVkvO5D1kopGG49YjE88

co ARa26 -- 3SH2 QP on i Vet Br BQ-0755 _039y DRocumoent reossosei C(4nCoder THOT) Bevseo- 3l1-394 Atention: 8(e) Coordinator g UoSSo. ECnviroonmemntalviPerotnection Agency `Washington, DC 20460 ontaiin NO CBJ 2Ean - = Dear 8(e) Coordinator: elie AmmSEoHQ---0381---03--94 s F This letter is being submitted as a supplement to information we communicated to the Agency on January 10, 2005. This evaluation is part of an ongoing study, "Ammonium Perfluorooctanoate: Cross-Sectional Surveillance Of Clinical Measures of General Health Status Related to a Serum Biomarker of Exposure and Retrospective Cohort Mortality Analyses in a Polymer Production Plant" of over 1,000 employees at our Washington Works plant. As described in communications to the Agency on January 10, 2005, study participants were divided into four categories based on job histories: Assignment 1. Currently working in PFOA areas 2. Formerly worked in PFOA areas 3. Occasionally works in PFOA areas 4. Never assigned to PFOA areas Number 259 264 160 342 Median PFOA (ppm) 0.49 0.20 0.18 0.11 `Study participants' current residences were plotted on a map of Wood County, WV and `Washington County, OH by category level of serum PFOA, using EPI INFO software and geocoding basedon the U.S. Census TIGER database. The PFOA serum level categories (in ppm) were: > fomost0<to * from0to<0.1 e from0.1t0<0.5 from 1.0t0<5.0 from5.01t0<10.0 E 1 ENili dons, AE No the clear associations between serum initial plot of al study participant lreevseildeanncdesprboyximmeiatsyutroepdlPanFtOsiAtesweerruem apparent level in ecxaptoesguorrey.anHdowwheevtehre,rwthheeyneovnelrywcourrrkeendt ainddarjeosbsedsivoifseimonpltohayteehsadthlaitkewleyrpeotneenvtiearlafsosrigned to divisions individuals with with likely serum potential levels in for the PFOA highest exposure category were plotted on the map, 6 for this group (between 0.5 of the 7 and 1.0 NppNmE) dliirveecdtwiionthfirno5mmtihleepslaonftt(hOehpiloa)n,ttshiete.dirFeicvteioonfctohnessiestseenvtenwiitnhditvhiedpuraelvsaliilviendgiwniands of itnhdeiavriedau,alanidn tohnies ignrdoiuvpidluiavlescuinrrtehnetltyorwensiodfesPawreksetrsobfutrhge, pWl.aVn.t,siatpep(rOohxiio)m.ateTlhye1s0evmielnetsh from the plant. We emphasize that not al possible exposure sources have been identified and analyzed. (`dWihfefnertehnecersesbiedtewneceesn oifndailvlisdtuuadlympeaarstiucriepdanPtsFwOeAreseplroutmteldevbeyl raenldattihvee mexepdoisaunrevaglruoeupfsor, trheeliartijvoebvsaelxuperse(sis.ce.d, paesoppelreceinnttahgeeshiogfhtehnedmoefdithaenrvaanlguee)o,fpParFtiOcAipasnetrsuwmitlhevtehles hfiogrhtehsetir jHoobw)eavpepre,arpaerdtiecqiupaalnltysdiinsttrhieblutoewderwirtehliantiavnedexopuotssiudreetghreouSp-smiwleerreadmiuuschfrmoomrtehelipklealnyt.to be found outside the S-mile radius. A copy of the final report of the larger ongoing study referred to above will be submitted. to the Agency when available. @ tc A. Michael Kaplan, Ph.D. Director ~ Regulatory Affairs and Occupational Health AMK/RWR/RCL: clp (302) 366-5260