Document R2OZbQ5O8a0nbyoJO4nRaXJ6n
FILE NAME: ZD^D/
DATE:
DOC#: ^D/
DOCUMENT DESCRIPTION:WZ:ZZ /,
I
100
BR.IT/SH JOURNAL OF JNDUSI'RJAL
the 17 p Iients sl.lff'ered frol'll anorexia, all but 1 from
markCl;l Ii o( weight. and all but l from in~ dY11min
on ~rt' n. U:iuah, wulct\1!$5, insomnia. and tacby-
Qlrdia
promiocnt. Ext~tion of t11Q ~t by
x rays sh wed various abnonnalJlies in m0$t as.cs. In
$lap I I re was a fine diff\floC sr:u:iulatity ; in stat" 2,
a dltruse ticular paneni on lhc puular backsround ;
and in s sc J, distinct nodules oppauin11 uniformlt
througho t the IWlp. Palholop:al ~mioation showed
focal aud diffuse c:hronic ~ulomatow inJ\ammation of
all lobes f both lwip. and mblcutt rirosmsive focal and
dill~ h atie nec:t(llS.is. Many kinds of tttatment were
tried, wit no effect.
H. M. Vernon.
lhey developed y reticulation, and nodular changes were not oblcrved der 30 to 52 yW"J, The d~t huard was also jp"eat in n working in the final stages. such u the polAben. N ules in thr: lungs wen:: senc:rally peripheral iD distri ution. The author observed 6 cases of lymphoglandula calcification or eg&shcll outllile.
h is suggt.atcd t t the final procwet should not be carried out in cl d sp1u;a. A shed with open sides is
better than one w th walls. aod machines which create much duat ;hould be fitted with appropriate ~moval systems. It may prove more effective to give men filtered air uoder p ure rather than masks with filter&.
G. C, Pttlrer.
A Hlstol cal Basis for the Rrdculatton to be Seen In
Lung Retention of Quartz Dust Sll1iller tban OnH&i! Micron, HATC T. F., iind Kfr.losvo\tTEll, V. H.
XRay Photographs In Pnrasnoconlasb. (l...c5 bases hi$101i qucs dca ima~ radiologiques de rctiC\llation
(1947). J. iMlus . Hyg., 29, 342.
oble
da,a, Jes poeumoconioses.) POLICAP.D, A. It is weU known hat when quartz particles of kss than
(1946). Arch. Mot. Prof., 7, 3S.
I I' in diameter ar inhaled they arc much mo~ active
The au or describes lhc various stage$ of reticulation in pncum oiosis. Silic;a and coal dU$t QD be dem0n~
than larger pankl : the object of the present lnVC$tiga tion was to dcte e if experimental &nima.ls would
or strated ' tologjc:ally aloog the peribronchial ducts, and
retain a sufficient mounl sub-mierosropia.1 crystal line siliea .In their I && to produce evidence of dama~.
the distrib tion seems to correspocd with the radiological picture ; ut the dust i$ practically tra11sp1rent to x ray$,
The experim1mtal u.st was obtainr:d from commercial
and it is eoessar)' to show up the calcium dc:pOSit by
pulverized (Ju!U'tZ y settlement in water, the partides which remained in uspension to a depth or I cm. after
rukro-inci cration
L. Roch(!. 5eltling for 24 ho bt!ling collected. The median sii.t
of the pa.rtid~. as etermincd frnm electron mictO$Cop1; Workmen In the AJw Granite Q11arrles. (La photographs, was 18 . Thi: tr:st material ws~ kept
r:gli operai di:lle ca'e di 'gmnllo di Alzo.) in water suspensio and was atomized by mean!"> or a
, E. {!947). Med. d. LA~oro, 38, 173.
high-velocity ejllCl r. An air current of 1 c. ft. pe1
Palie11ts froll'l the granite quarries of Al.z:o were rninutc-heated 011 its way--carried lhc du.~t inlo the
w.idied. t is concluded that thr: pessimistic views of exposure chamber, 3nd it esca!')ed through a high-
Ameni:lln uthors conurning the mcvitability of ~ihcoSlS voltagc electrit prcc pitator, whereby the mass conccntra-
after a ft' years' exposure arc 1.1nrcasonablc.
uon of the d1L~t i the ch.Htlber was clctefTI\incd. It
The roe s worked at Aho are volcanic in origin, and amounted to lS mg per cubLc mctte. Gu1ncaPi&.S were
the esscnti I constituents a.re quartz, orthoclast, orthor.e. exposed daily for riods of up lo 4~ months. Lun&
a1id mica, ut other mllleraJs 111~0 occur. The total silica so.:tu:ins from the n1mals showed that in every ca~
i:ontcnt is aidy high and only a htt!c below lhat found in after ;>O weeh' exp sure the bronchial lymph nolic.s were
the Ilnva ian fore$t diHrict. 1-'re:-c silic:i tqtHll ti) enlaq:cd to rrmrc t r1n three tirne~ the norm.11 dinrneter
n.:prcscnt~ 40 tu 45% of the w1.1J ~llK:j. ()uarry111l: t!. 'I he fol!owmg pro rcss1vc 1Mth1.,lug1l:<d ch.1ni.:c~ wt:rl'
.'.Lii icd on n th1cc pr0<:C$S:>. In 1h,, liist the ~ton~ h ,ut on~cr.td with mer~, ;rn~ expu~urc (1) A.n ucrnmul.11101)
,1w.i) from th~ hiJbid(', ltl 1hc ~corid the l.ilrxk 1!! \.\H 1nw of mn11onudc:1r r1 rctKul,11 L<:ll~ m the ..cpta ,\lld
ra smaller ts, .ind 1n the third ll IS lirmhcd to ~hape. .ilv~oli: Jte:is were 1s.ctt'tc :ii fir"!.t. but hcc;rn1e contlucn1
The llr~t p r:x:cs~ is danuerous and the n1incn nttcn wml- anc1 1111ally involve large po1 uo11> of the p:ircnchyma.
on ;,i $tl.'<'P lope ~U$pcndcd from ropes. HC)lcs driJlctl to (2) Tlie lung chang~ were follc1we<l by similar chan::cs 111
:o 1.ikc cxplo 1vc charges may ho metres long. jmJ the the btorichrnl lymph rwdc~. ull lin.i11v tne cnlarl(i:d t10J~
<lnll~ ate t 1med by hand whik b1;ing ~truck Sll :1' to wa~ Jlmn'ot ill led w11 1 ,dtered tissue. /i. M. Vernon.
prnv1dC' .1 rfectly circul:i.r cro\.s-1oect1on. At mtervals the dui.1 a cu111ulJlcd in the holes i~ blown out hy a
~me lfrmarks on Aloc~to~i~. (<)udqu..:~ rnmickratio11<:
mcrllil1111:al pump. Dlack powdc:: 1s the only ~xplm1vc ~ur l':1m1antos~ ) r ROtJSS!.AU, I.. t 1947). Sem. ffof.J.,
used, as d n:imJt(l sha.tters the stone too ca~Jly. 1 he Paris. 2.l, 1811.
:stone 1s st tilled iu thm: planes. but only expert..~ can
dcti:ct th with case. 1bc cuts made ln the stone musl Ex11erim1mtal Asbes osis. Pnthognoinonie Value of thf
be .alig.ned ith these factors ln mind. The di\1ision ot
" A)bcMos Bod). (Am1a11toi.c c..werimentalc Vakur
1he MO!l(l IS :irtly Ci:llt ied out with y,cdgcs. TI1e surface:;
p.1tho!(11omon1quc du" CtHl'' <l'A1111.111tc '') ( ji~ol1x.
uf lhi; mm ~ whtC'h have lxcn rou~hly cut to ~h:ipc .tl"I.'
.\1 tl'/.17) Sem /lip. /'11ri1. 2J, 1~14.
lim'h'''i w1t hammers and ~niall l'~t\1ng tonls. l'ol1;h1n~:
-~
1> i:.cnn;ill. 1wrf1.i1111ctl hy rnach1ncry m whid1 arc th~ AJ.IK-;ito~i~ und l'ulm 111'10 Tuhlrt-ulo'i'. (/\rn1Jntmc c. "!
:ibr:1!i1vc n1 tcnals .inJ w31i:r. ~<Jme ctry poli>hmg is
lulx11:ulo~ pulm 11lau1:., D1:sMLULtS, R . G11wu'<.
dune.
r. ( Of 37 e amincd, 9 hi;d retkul.ir ch;;nges, 14 had
M...md Rlc;HMI,, 1818.
1947), S('m. J/Jp., }'ans, 23, .. 'i
~1lii:ot1c no uJes, I massive sitkot1c 1:h<1ngcs, 4 assoc1a1cd
't tubcrculou arid S tubcrt1.1losis "'ithout .s1licosis. The A5beslosis and Ca o( the I.uni:. (Amin111ose et
pcriQdS spe t m th~ quarry vari~d from 20 to S2 yc;m.
r:1nccrs pulrnona1r s.) DtSMHIL~-'' R., Ro~J~SEAU, _L., .~
The :iverag age exceeded (iO )'c.ar}. and the diagno!;CS
GIF\OIJX. M. :in SIROI.~, A. \\947) .\1m. lfo11,
dc'>i:rihc:'d n1dcnce.
ere made exclus1wh on the 1adiolM,1c<1I lie Hi-:utcs ~howcd that the du~t trn11rd w.is
}'um, lJ, 1820.
!!,fCO.!J:~t fur th0i.e who wo1 ~(d "'r-h ch1~l ;111<l harnnw1. The...:- llltn :id Ren~t:.illy worJ..cd l.'r ~()to 2~ 1~ar> ho.:!01\'
'1 hc>t' four pnr-::r... ,,1lll: (rorn ()udx''. C'.ui.ldJ . .,.Jtcr~ .,.;vc1JI workers 1n th .1~!-.;~,!<J' 11111K'~ ll.l\'<' 1.x.,11 ~1uJ1cJ
lOl
ABSI'RACTS
,090 had appattntly no
lungs. Of e:: found
hool di5;1grec:s wi1h t e statcmoeaottaaonfimOpa<.t>dr-
men, of the 271
mwehnornwi1othsedeinmostnamgeab[leofabsnilioenonsia$li
d
h dyspnlXa ffcr\ld in
or l1a'1heoerttQJ(iauactelbponercciunsmctohceo1p1ro1dosuicsdtiuoentoaoasd
rtoogsirsm1$ of pulmonaO'
or asbestos bodies in
thal 23% of tlfort.
of th Of the
second-stage
the third stase
ca. 41
silicosis
su men out of
workers
ay, and in
ube ous
i1u~teulosi5. and
putum has n
Iha! the
o value
presen
in the
d
llriJ4'IO'1Salltioenftass, bseosmt0e5ios.f
t1h3ishawtldUdsYs$ypmn<p1toa.m,AbOo1,f11thelO: m%eon(wS7llbtltsc.plin.i
tly norma.I Uy to detca
::u
1ithoheuosmueaaungaivlseos bttrpieofndct:Ad minp1tihoensf !1lroywfinogr 1p8dpyeersa.rs, Oanned
hltuhanid$8$m1n4p%tohm11dodrystopoa<snses;s ititsi.s iidmmi$ppo0rrtatanncic:.
The authon 'V(n to thiA
whuapderwieoorckredd rieAsptihraetoarsybe$sy1mosptoin1Tdl$ ollylndnuaritlI&~ tdhyeslpans<t n3..
lhcn:Core symptom
c:onsider by the:
Ftrheal\tChtheeovcnuncot, rieflts, is
io
judging in doublful,
He complained Asbi:Atos bodie.t
of coush 11nd were found in
an hi$ i
ut\ln'I, but no ve shown a
tubeN:le
~Wld
c:apaeity ana th8'
and te:sts
compensation of the venous
tension and &tirll lhc p
P"d of
blem.
bglaadslslia.ppReaardaniocle"lipnhhyi$i$lu5nagisd
to
[vo~
ristu).natTehlyisthi&e t1hUeuosntrlay
circulation do not hi:lp in tlucid
G. C. P1tli.tr.
cion c:ii;e
ii to seen
o paor at th.is
hto0$dpeitmaloimn twnhlliecht sbc:sto~is
1uhriansgbeleifn~.posAsinbolethteor
The
011St
Hazard
In
Tremollte
Tlc Mhlhlg. d,, 19.481.
make a paueot,
wdhiaognhoasdis boeefn aexposed
t
ulbacc:e$dtol:sll\1d$uCs,t$fhoorw2cSd
m SCll'M
in
L. (1947). Yal~J. Biol. Mi he literature on tale dust
is
reviewed.
~~
riW'S both he e~le~
or yneoacnlinanjcd:alwohro
died fro radiological
$igns
any abnormality
e
illTE)unrcoupmeoacnodniionsitsh,e cUom.Si..$A1..inhgave
I dift\ mma.ria
ICDetaiited
of 5 fatal
hi&Gliuronupxdeurx iag~lifaaev.cinheaamp~irp, draabil it&fo, ransdevaedroalg tmoocnrlutlhtdlsu.,
of i fibrosis, cases in
th;eim: Von.$g.At.alacr-ewaoirvkeenr,s.n\oinSenruoscraonpdsy
fl
dings being 'llers in St.
;Ti:rh.beesrateb&bitJ&u,skt ililned
aft.er
periods of
sbcs
rom 3 to 12l l'l\O bodies. The
dog
and no 1
only the
qLuaowtredc.n~ACosutundtyy, Nof.Y\.alels o1c1taitlie.ldl.e, Tahceco lpeamniiendedbisy
hshaodW1l::1d0 na.oSbkc.:ssi1o0Pw$$i5edaftleersio10nsmionntthh elxupnopsw~ d:
asbestos ror111a
atrmnborloiut.e~invaarfiibetryouscasltlaetde.
iubes The
free
silica
e
l %- In min
nti:ot of the the: drilling
guinea-pip ~ In
sheose animals th bodies ;
he tra fibrtS re
cthhiensstatgheesnolvfeoli
f
arc lhc
dsustyisanstdatleitdtletodubset lceossnttrhoalnLS usedg.er)Daurcsl-gci ennc.entAratutohne
tion of
rup1<lly
asbestos ccvcrcd
bymp1chraogsoccoyp!1icC
cell bl
di;ngJT1froovmemedntano\aged erated red
ifisdiulrrlcs:sth(es1m1.mnptelerdinlbyts mcriudsgheet d1,m$pCmrCdC:tteds,ommiell duisnt~poenbtbrloel-
fibrps results alveQ_lar walh
in
; the
ha:mog.lobin
f
by the pha1,1ocytes
om the lib hich already
tndose ticular
up
atcs
m mills.
a1r-scpa1111ed,
measures are used in
and bagge the last two
opeti1tion
urvey showed
,
pulmonary
cel1s IS talcen the .asOe<;tm
Hbrcs,
Subcu1aneo
igs of sus
~5 0 gumeap
s or
nsions
10\r of asbestos
in
gra.oulomatou.~
tlhArQn5i.~ininiu1a4l5%rndoioflnog11cmalenstxama ianreadn,uglaivrtint
a soft hazy of the lWlg
or
ioneh~svcioectnisooilburietns1uolotedasbines1tohsc
pmdui:li
boo~icn$.ar
n of hen
hhoicwhevler~I.thoef
into'w
"fiegldrosu, nadn-dglainsss"om.:1epcpbealea~r~a5nhacocwnsodtuhlaattioofn thraodi laoggeicdalSJOy oo1rf
l suspension blo~d had
wbaeseninj1enc1tcecdte<iintom1mec11a
eleycobnefsoidree,rsat.hsbatt.stthoes
silicotic type over libror.is
.
A
wa~
!<I found
in
49% the
of the coot calcwori\e
ols .
(carpe
Fibro~1s
51,, of
amOrl~
bodies were ~r~m:e of
fmmd a\he\t
al o\
t
er a mont hodlc~ in
h.
;p11
th
\Hn has lungs.
si~nitican<'C,
wWoirlSkerdr~;1)t1v(itnldy minor5e1prC'v;ilentlhammcongofmilplenre.u~ hCaXn:lllllL):>>) o;
or ~111cc
It
m1phe:,
~.'~~uc
ci:1m~ll,C in
Mid ll1d1<i
D('.srrn:ulc~. (11rn11x.
d re:
report wa~ no
a puuerit, ht~tory of
n<l\)l'1.w~J1lrHs1.:'1 Swy;mi~pHi;mrci~'(ct\\<t'fht'ahne tthnec1. drca:ndlf'.Oe t'nlP i!cI.VCi:htuanbegr
at.;:uetide.4~~4ulo)c~tas1..>,
1n
He
who),( !am1Jy ti.iii WN l;cd
111
,t, e
b:iggc:r of .i~be~w~ began to cxpcric:nu:
cmuligo~hits hwavaes sSllliigllh:tC!S~ICh(ii. ~hleT.riquthcasnofcrlapdeCiot-loldp.a Iunc mfra3t%ern1olf.l
101 .o ayeoanrsc:Oonrtf.tcarcrol(m) flyil.1;-.H-rscJhb~' oue~h9 amnodntehx~pab:etoforaze- tohfete2n211Jfmwl'n1tdsc1pdoa,a11h~!cm~1p1.c and "ap;p:ihn;repnlla!qyutn t"hehva1v!e.ternao
dyspnn: t1~m. He
ath,
bwehciacmhewmHot<(i:u~i:v1~01d1uyt1i<llr\
m 1lo,i5 :ind
prc~ded
asbestosis. and paved
prelelautriao.n wtoere1Cf\lolOl!\n.l!d. .infeTchteiosnep,aann:tndcmhyamy anootr
;i~.mc1atcd
Ith chang~~
hTishedaeuth_tcomr t.hvge\>tuC}xth.ir1<I:u!hloem;1,>ubcuMt O,i"dit lit tthuabtertctuu;lyo~hia~veamndl
....;1thhe.fichornr~ris~p11o1 nthdem.i:1: ohii.lmar:ngtlandes
; In sotrle plaques ar
~ no other
considered
tai>h.srenbocw1J_1aoyso1l~.1t~h1~~~tnl'crTo!hl1y
,1ss0<:1ativn
admimd m
I
f rituin
l:lut
i~
doubted
iltnuongbechsaynmgpestorwnlecrses,fo11An<lm;artkheodc;osnimiosiliasriatyn
s 1ndieate<l ;isbcstos1s,
pneum
tn
the Uo1~0
~me1.1lc~.
Statt.s,J Rouss.<.>.au.
Gi1ouJ1a,.s a.rdtoSsii:r;oiasndrecco:arndcebrrioeff
bTehtwe ;eieunthmtre<m:oornll:thcidtea>lcthnact:ctch:i.sssadruy.st carnesLai~Wet,iniHtaeleri<ik
deetaihlsingof :ZITphact1edmasirnwhthoathaad11.:mrcu rnwt>olllf!Ith1ecalsuengc:iwnnlloht and that it:; 1:0111rol l'>
tssels in Sili'o~is. rI .:
,,i" tah~hc~10~1~ ha~ 'd
hc:rn
l'fo1
11.:tordcd
"di ther:
hcf be
o !!Ct
er JI
.11olr.mcnt wnh 1)lay an impor-
Chani;c~ in the PulmonarypoVlmonari 111on1 dc1,
netl t '>Jll~m1.) IAI, L (l\147)
Expo~ures I~. btth.eienat.l;!pot~awtnc(niin~nrihti;k: 1ft'J~>ihlt1'c&:me1n~eh11~~aodfmpllul m<l utnuif.i,ry,cHaracrdini1o1mi.:.a.,
;iltcr: NlJN1:1..,:-i1;
Ci;,~ARO.
A . .md
PF.CtH
i
Med. d. lu1'(1lfl 38, 307.
l-loJEN, RJ,,,
Dysllft\\'2 of Effort
h1
Undtiwoon su
JaWdoyrskpenrsee iPd'eCtf:ooartl
ues 1cmarques
houill~rC$)
ApPBising
to Silica Dll-5. L .. and Hv>.rr, E.
C.
p947).
Hl!Ml!ON. W. C. 65.
1
dt~nJs lh~>ir.: Mcihnea.~I,~ o(uQvurd1qc~ou fond .emJ..p(l1o9v4' )d. .inAsrclhe:.s Mf11. pHJf,,
i11dustr. ll;'lf, 29, ~
lirnrn
h11 gcly on
of the al par11cli:\
M>.RnN, E.. arid Rnc1IF . 7, 197,
of coalminer'S
Th sili..:.:1
e mk of
p:.ir111.:le>
>1
inh:tl<!d,
and
it
1~
C~Jl<.'<.'IUliy
1:ons1dcred 1 th()S.C ol l (()
3;1.
JfC
the \ht
~1.1. ind
n 1h,1t
The
~i&!ltlk<irKe
wuhoul
pi..uflm<Jyo~npnJ1lr!y.11,1~1,110g11
OllPS
of varying
dcgre~
c~amine<l 1)61
c1;1,f101'>..!~~;it,hll:\Ht!l .itld dJlh!U<>\1' !1 I> W<~ll knD
w1.th and
I of \<:Vet1ty
I}
dN:u~:.ed
"Jlw ,1rnh1r.>