Document R2O6K02JDm5RqVVxaw2OvZjMz

July 1. 1964 Mlaa Clair* Barton Poison Information Canter 4oi4 aunaet Boulevard Loa Anti*lea, California 90027 Dear Miaa Barton1 Confirming the information which 1 gave you today on the telephone, the following data relate* to the toxicity of our eynthetio fluid Pydraul AC. In animal toxicity atudiaa the minimum oral lethal doa* in rata waa found to be approximately 40 g/kg of body weight (An oral UD30 in rata waa reported to be approximately 52 g/kg. Aa I told you on the phone, I queatlon the reliability of an u>=o of thia magnitude. Consequently, we normally maiee reference to the minimum lethal doae rather than the LD50 for thia product). In rabbit* the oral minimum lethal doa* waa found to be between 3-5 end 4.3 g/kg. The greater aenaitivity of rabbita ia typical with thia type of fluid. When applied to the akin of rabbita the mini mum peroutaneoua lethal doae waa between 4.0 and 5.0 g/Icg. Although thia indicates that the fluid may be abaorbed through the unbroken akin, we feel that the lethal doae la auoh that accidental maaalve akin exposure to man la not a serious haaard. In appropriate akin and eye irritation studies with rabbita the fluid waa classified as a'mild irritant." We know from experience with humans, however, that if the fluid ia accidentally aplaahed in the eyes, the resulting pain is out of proportion to the degree of irritation to tisaues. Industrial physician* have used pontoeaine eye drops to relieve the pain. In relation to the effect of the fluid on the skin of humans, w* know that the product has a solvent action for the naturally occurring akin oils and thus, like many paint removers MGNS 091089 Miss Clair* 3arton July 1, i>u4 Pago 2 oisU common solvents, can lead to drying and chapping of the akin 11* there is prolonged and repeated skin exposure. In acute vapor inhalation studies with rats, the animals survived a six-hour exposure in an atmosphere saturated with vapors at roots temperature. i')*e animals did not appear to be seriously affected by the vapors, droathlnj remained regular and Irritation was sufficient to produce only a alight degree of lacrlnation and salivation. We concluded that at normal temperatures humans would not be exposed to significantly toxio vapor concentrations, fhe low vapor pressure of the fluid does not lead to significant atmospheric concentrations. If the fluid la uaed in ouch a fashion that it may be heated to several hundred degrees Farenhelt and there is an accidental release to the atmosphere, the vapora Mill be irritating to the degree that humane would not volun tarily subeat to prolonged exposure. If, for sane reason, workman aould not escape such an exposure, the effeats of inhalation of high concentrations of vapora would undoubtedly lead to irritation of the eyes and throat, nausea, vomiting and possible reversible liver injury if the exposure were prolonged auffloiently. I would be happy to try to answer any further questions that might be raised by the person who directed the Inquiry to you. Perhaps I could be more specific in terms of proper use and safe liandiing instructions if I knew the problem which l<d to the query. If I can be of any further assistance, please do not hesitate to let me know. Very truly yours. dimer P. wheeler, Manager bnvlroncientai liealth Xedical Department if'.; I raj b coi /rank V. Nemits - Monsanto, bos Angeles Note to Prank Nemits -- Miss Barton said that Union OH Company had asked her for toxicity Information on Pydraul AC. I believe she said a hr. Rich was the person who called her. EPW MONS 091090