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nefi - --_ --~ AR2R6- 3465 69 000654 . AR 226 - 346L 8 IN BLO - Histone 1 ~ 1879 c-8 fod in blood of Dupont workers. 1978 Informed by 3M that C-8 is found in the blood of exposed workers and persists for a long time. 1980 Workers with blood C-8 found to have normal liver function. 1981 Birth defects scare - additional sampling. 1982 Blood program continues on voluntary basis - no trends noted. 1990 Formal review of blood data. 1985 First Syear "snapshot. 1993 Journal Of Occupational Medicine study of 3H workers. 2 000655 as mem maemo ac: eo "3 s1000 owtToRn THIS 15 THE ONLY REASIRE VE WAVE GF TOTAL ENPLOVEE EXPOSURE Prostens GIOPERSISTENCE WARES DATA INTERPRETATION DIFFICULT suru 1s stv LEKIHY MUALYSISISRUNBYORLY ONELAB NO AEL 000656 WASHINGTON WORKS VOLUBLNOOTDTAESRTINYG 0 - <1 ppm 1-<3 pm >3 ppm TOTAL 1993 1994 9 47 2 5 2 1 13 53 |~ MNosystematic comparison with air sampling is possible. a] C-8 specific GC analysis run by National Medical Services. Correlates well with new 3H analysis. | 0006577 1995 C-8 IN BLOOD "SNAPSHOT" PURPOSES Mpornoigrtaonrs.the overall effectiveness of our C-8 industrial hygiene Create and maintain a continuous data base for epidemiologic surveillance of our exposed population. Provide closure for issues raised by the 1990 data review. : | Honor employee requests for voluntary testing. @ ~ | TEST POPULATIONS Exployees in C-8 Jobs (2 of 160) rEemspullotye>e3s pnroat (i9n Co-f81j2)obs with a previous rPeenssuilotne(r9sowfit1h8)a high previous Volunteers (18) . 000658 RESULTS SUWMARY - OPERATORS JB DESCRIPTION AV1E0R9AG5E (n) AVER1A9G8E9 (n) O08PE autoclave 23M 3.0 (4), 7.0 3) GPF polykettle 2.6 (8) 25 (3), 8.5 (1) gp dispersion 05 (2) 10 2), 7.5 (1) 0gPI FP finishing 2.0 (6) 2.0 (6) 08h FP packout 01) 0PM C8 dryer recovery 1.7 (2) 18% FEP polykettle 2.3 4) 18% FEP extruder/oven 1.5 (6) 0.5 (3) 18% FEP wet finishing 3.0 (1) . 0 18% rFEPoprackomutt 0o1r @(8) 189K FEP safety/disp 21@ ! RESULTS SUBMARY - MECHANICS sc R/dis/on 14) 56M general shift 118) ssNs process EAI 08 () - GMA general shift 1.15) -- 6M FEP E&I 0.9 (1) 000659 & - HALFLIFERESULTS FROMPENSIONERS DATcEsPEM 4/89 5.7 3/87 1.2 9/81 6.5 3/88 2.8 8/88 2.4 7788 5.9 RDEATT.E co 1/2 Lae pamEeE (YEaRs) yor aes a 5.7 oz aes 11 2: oss yes 1a 3.9 1/52 yes 2.2 6.5 oes aes m2 5.7% 12/6 ss sa 4.00 3/85 3.0 4/85 3/95 .14 2.3% : . ~3 oz 6.3 12/52 395 57 3.5m san an ass yes aa |{ For + results, averagne e=s3.9 sigma = 114 | using logn = -.301t no t1/2 2 000660 orEERopsERVATIONS 1. vouowTEERS a)one of 17 is above 1PBK b) Aveofrothaerg16eis0.4PPK 2. ACTIVEENPLOYEESWITHPREVIOUS HIGHRESULTS - notiinn cc-o8s jJoobb Do25wn sa52me Up%1 ~<D 3. THREE BMPLOYEESOVER 3PPKFORTHEFIRST TOME | -- 000661 3 Tes PoPULATIONS 1. Employees in C-a jobs (82 of 140) 2. Ermepsluolytee>s3 pnpotm i(3n Co-f512j)obs with a previous 3. Preenssuilotne(r9sowfit19h) a high previous 4. Volunteers (18) || 2 000662 2 OTHER OBSERVATIONS 1. WALFLIFE ESTINATES FRON PENSIONERS nih Average = 3.8 years Sigma = 1.2 years 2. Younes 2) One of 17 is above 1 PPM b) Average of other 16 is 0.4 PPM 3. ACTIVE EMPLOYEES WITH PREVIOUS HIGH RESULTS 9n) ` in -8 job BtonoEsme ad not in C-8 job 6 2 1 4. THREE ENPLOYEES OVER 3 PPN FOR THE FIRST TINE - || . - - 000663 | || | | 9 PATH FORVARD Finish Data Analysis Exployee Communication Site Industrial Hygiene Efforts Toxicology Mork (Do we need a BEI?) Continue Annual Voluntary Testing Take Another Snapshot In 2000 . - J --- 000664