Document QkaxvE5MyLz10v9Ej02vLj7kL
AR226-1388
FE . Cre sea
Wi ue Ge sesreRa J. T. SMITH N. J. IRSCH C. F. REINHARDT - CR&D
,
B. W. KARRH - ER
;
------
H. E. SERENBETZ
E. I. ou PonT pe NEM& OCU OMR PAS NY
WILMINGTON, DELAWARE 13898
AR a6 J. W. RAINES 1388
[----
vay 26, 1981
FPEERSSONARLA& CEONFEIDENTIAL
,
3VP.AOSLHHY.IMNEGTRTOODPNDRODWOURCKTSS DEPARTHENT
C-8 PROGRAMSTATUS
It has been several weeks since the announcement of H's fFehaiannetodsinveEgeasnpeoainfratenant.ehadend tCferouremralmttouhocnegairetcniaaiotnciniomnaposlofteaGtnoeftsfiteeaicmlntpgel,doofyeffeCeus-mr8atlhaeeatrndethmbapltthloeooydtesiemussebasmepfiqlrniuodnemignc,tattheed
and some follow-up to see if birth defects may have resulted from exposure to C-8.
Although these programs are either just under way or
still in the discussion stage, a status report is in order.
iSnhfeonrm3aatitonneYouWHiamtsahkyelylocuhroaocstieimvmiettodiieassth,earemSataysfofmb.ee oofOfthmtoeherrempoawrrietdsesspeorfnesaitdthieviepnrtoergersatm., be glad to IafssyioustwiwsihthtoMepdriecpaalreora Hagsekneelrlal review. communication, we will
RISK ASSESSMENT (Attachment I)
The latest risk assessment letter of May 6 from Drs. C.
F. Reinhardt
refers to an
and B. W. Karrh is included
earlier letter of April 10,
for
and
your
this
information. It
is also attached.
HASKELL LABORATORY STUDIES (Attachment II)
program beiE.ng D.undCehratmapkneeny'satmeHmaoskeolfl 4/L1a3b/o8r1atosruym.marizes the extensive 5
EID090076
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000159
. "+ J. H. TODD
-2-
MAY 26, 1981
HASKELLLABORATORYSTUDIES (Cont'd.)
aTheno-ienfhfaelcattioenxpotseurraetolloegvyel stinudyfeamiamleedraattsdeisterpmrioncienegding on uScsheeddubleeg.innFiancgilitthiiess weatek thfeor EbxlpoeordimeanntaallyseSstattioonsuaprpeortbeing btehissomsetudryesudlutrsingatathtewo-ewndeekofpeJruineo,d. theAltfhuolulg-htertmherteestwill will not be complete until year end.
Shacvreeensitnagrtesdt.udieIsn faobroutantahlrteeernmaotnethsdiswepersshionugldagkennotw if we mhaovnethsa pworuolmdisitnhgencabnedirdeaqtuei.redFutoll-csocnafliermteasbtsienngceofofseveral teratogenic potential. iBtecaisusedifoffictuhletratopidrelealtieminaatnioo-neffoefctC-8dosbaygefemaandleblroatosd, Lleevveell oifn Cr-a8tsintohuamnanasc.ceptAabsleeconedxposspuercieesl,evmeolreandclobsloeoldy racetliavteedC-t8o hisumannosw, avwaiilllabblee.chosIennforsmhaorttiloyn. aboTuhte rhoawdioi-t is aucsciunmguliat.ted and held in the body will come from experiments
A reproduction study is still in the planning stage.
BLOOD SAMPLING RESULTS (Attachment III) through MayAtt1a4.ched is a summary of sampling results available the dispersAisonexpiesctbeedingfroumsedpreavreiouisndiscaamptliinngg,iowsitbelsoodwhelreevelosn.ly results areSamavpalielsabflre,om wDeorwdirlelchtbearaeblejustot cboemipnagrerectehiivsedp.iantW,henwhere ednicree.ct exposure to C-8 is possible, with Washington Works' experiWashingtonWeWoruknsderasretanbdeintghatdissctursasteedg.ies for further sampling at
"W.AD.BINGAELSle MEANNEURFGAYCT&UREINNVGIRODNIMVEINSTIAOLN AFFAIRS
Attachments
EID090077
g
000160
1" cam ei
E. 1. bu Pont DE NEMOURS & CoMPANY WILMINGTON, DELAWARE 19898
TOXICOLGCY AND INDUSTRIAL MEDICINE
Page 1 (carbon copies listed on page 3)
:
May 6, 1981
PERSONAL CONFIDENTIAL
MENO TO: PH.PD,E. MOSNETRCEHNBAENTIZN 642
FROM: BC.. WF.. RKEAIRRNHH,ARMDDT,, MEDR,D, CRNE-D1,140H0ASKELL CAA
Lovie
TpAweRonrTuFn IucToFCo-1c43 tC-a8;ncCAS-at382e5-26-17; Ref.: FCFCR-e1i4n3h,a"rdtdat&edBWK4a/1r0r/h81t.o HESerenbetz,
FC-143Thecaurseefdereanbcneormmaelmoeydeesclreinbseess ainpirlaott festtuusdeys.by T3hMe inmemwohich jroebcsommwehnedrse itthahtaswboemeenn doefmocnhsitlrdabteeadrintghatcatphaecrietyisbeporteemnotvieadl frfoonr bexapcoksgurroeundtoleFvCe-l1s43 (a0n-d0.4blpopomd).leAverlesas owfheFrCe-14t3heareemplaobyoeveesdehfaviened wbhleoroed tlheevelasirboofrnoergacnoinccenftlruaotriinoen oifn FthCe-1b4a3ckigsroiunndcomrpalnigaencaendwith pourresepnrtovinsoiosniaglnifaicccaenpttabrlieskextopostuhere fleitmuist."of 0.01 mg/m should
an
imOprriecgiisneallmyeasweureemsetnitmatoefdtboltaolodorcgoanncienctrfaltuioorninse.of
FC-143 by The back-
. ignrgounidt cionnctehentrbaltoioodnooffWiolrmgianngitconfloufofriincee,wodrekteerrsm,inewadsby0-m0.e4asuprp-m
l(eavselfluoofriFnCe-)1.43 Siutbsseelqfuewanstlydevaelmoeptehdo.d foItr miseassuermisnigtivtehetobloaobodut
H0l.oe0wv0ee4vlserp,bpym ien(i4itthipeaerbl).mmeetaahssoudrfelmwueoornuitlnsde.ogifveWIit lvmwaailsnuegstporneisnuomftefhdeicestahwmaetorkbreaarncsgkeg.rionudin-d
claetveelthoaftdethteectbiaocnk,grotuhnatd ilse,vellesosf btlhoaond0.F0C0-414p3pmi.s beTlheowqutheestion
ehaess a(r0i.4senppmw)hetshheoruldthebeaclcoewpetraebdletobltoheoddelteevecltiofnorlefveemlaleofemFpCl-o1y4-3 z
(0.004 ppm).
g
EID090078
<
BETTER THINGS FOR BETTER LIVING . . THROUGH CHEMISTRY. 000161
"0
+
Page 2
PERSCOONFINDEANTILAL
H. E. SERENBETZ
-2-
May 6, 1981
We advise against this step because our information is limited.
1. Trhaet eivsidienmccoencltuhsaitveF.C-11T3eriaatogaentiecrattoegatesn mienettihneg acunrdreDnut Posnttandaanrddsresaureltsbeisnhgoulcdarbreiedavaouitlabblye IMby 03-81.
2. dEveemnonsitfratthee ptreerlaitmoignenaircyit3yM, stitudyieisinaasdseuqumaetde tofor sreentttinagnimaaclcepsttaubdliees essphoosuulrde prsotvainddeardas,basiTshe focrur eThsetabhluimasnhmednattaonfowaccbeepitnagblceollwoercktpeldacsehousltdandaalrsdos. help in setting standards.
3. aBnedcaufseemaloef rthaetsuniunsutahleirdifrfaetreenocfeezbeertauteienngmale nFaCn-.113,4 btehetterratmmoadyelnoits bbeeintghesobuegshtt.model for
4. WtehatneetdhemabnayckgmroroeundmealseuvreelmeonftsFC-b1e1f3oreinvethecapnopsua-y lation of the U.S. uomen is leas than 0.004 ppm.
5. FenCt-14a3dveharssebeeefnfecitnsusien fhoumrandae.cades without appar-
not beWe chraencgoemdmenudntitlhatweouhraveaccmoerpetabdleefinbiltoiovdeleivneflormoafti0o.n4. ppmWe Tshheoulddepahratvmeenetnsoughhaveinaflorremaadtyiontakfeonr saigdneicfiisciaonnt instaepsfewtomolnotwhesr. eexxppoossuurree, toshoFuCl-1d43n.ot Asigfenwifimocnatnhtsl,y pexatretnidcultaherlyhazwairtdh olfowaeresdubstance that has been in use for many years. our coJ.nclR.usiGoinbss.on, Director of Health and Safety, concurs with
CFR/BNK/bjd
EID090079
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g
000162
wo
PERSCOONFINDENATILAL
H. E. SERENBETZ
-3-
cc's to:
JW.. RE.. TGaitbusmo,n,AdAndnm,n, DD--99060458 FA.LEL. FDardeen,ch,FGJF,r.;B-C22P0,3 B-17249 AG. AC.. HHaavpekna,, ILengia,l, D-B3-01437373 JC..TC.. GSmriitfhf,ithP,PD,PhoDt-o1,300R8SQ-210 JR.L.Ll SRhtoodweesl,l, FiPbA,f, D-N8-1414248 HB.. EC.. MSciKmumsoincsk,,JCrR.ED,CREHDa,skeDl-l6036 J. G. Aftosmis, CRD, Haskell
Page 3 May 6, 1981
EID0S0080
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000163
ACiLnE
on
Page 1
-
(cc's Listed an page 2)
E. 1. ou PonT 0E NEMOURS 5 COMPANY WILMINGTON, DELAWARE 19698
HASKELL LABORATORY
TOXICOLEGY AND INDUSTRIAL MEDICINE
April 10, 1981
PERSONAL CONFIDENTIAL
EID090081
MENO TO: HP.PD,E. M-S6E4R2ENBETZ
PRON: CB..FW.. RKAERIRNHA,ARDMT.,D.,M.DE.R,D, CNR-D1,14H0AS0K/E7L/L/ CAA
(pAmemonrTuEn TuctoFCo-1c43 tC-a3;nCAcS-3a82t5-2e6-;1)
ent toAtwyhoeutrherreqFuCe-s1t4,3 wies haavteerarteovgieenw.ed the information pertin-
heamsplobyeDeeuenrinnegoxpoktsnhueorwenm.aneyvHiyodeweaenrvcseer,tohfaotuardvDuesruspPeopnlthieehraalstohfuseFefCdf-e1c4Ft3Cs-1(43f3Hr,)omtihnefroermed
DePuyaentPolnertnastesosn)bMyairnscthroamta2c0,hfet1tu9u8sb1ee,s attwhhaedtnoseEfsCe-d1o4df3ai2l5cyauors(edda1y5s0defm6eg-c1/5tk)sg
t(oabpnroergm:al body weight.
Tmhaixsimuombsderovsaatgieonrawtaes thfartompraegpnilaontt ration for 3 full-scale study to
sfteumdaylesdesciogunleddtotolerdaetteermiinnepretph-e assess FC-143's teratogenic
potential.
T3eMraatnoOdlnorgMeiavsritce,hweda27ndtthweDor.dHaaTt.sakeCwlhilituh,scsieSevenentriiaoslrtsR3,eMsDesrac.ricehnR.tiPsaE.ttsh.oSltoagpSiltseatsp,,lesvStiasafinftded
CbyhiuFC-c1o4n3c.urred with 3M that the lens defects were probably caused
setxupdoiseuBsroethprcoDomunpctPelonynt.traatAnidonma3jMoofrplFaCgno-a1l4t3owistlthlaarttbedofeutsoll-dnosetctaelrcemaiunsteeerabatirodtgohesnagideceifteoycrts
nheaxdvpeostuotrheerseellaitmdeiattat,h(iAswEeL)dhoasfavogerewnootmoegnoboldooofdbacslhieisvledlbfseorarofisnegtFtCi-c1na4gp3a.caintyUa.nctcielpWtewaebrleecom-
mWSehunerdreetthoiattFhCaw-so1m4e3bneeaonnfddbcelhmoioolnddsbterlaaertvieendlgs tchoaaftpaFcCti-ht1ey4r3e beiasrerpeomatobevonevtdeiadflerfoimfnoerjdobesxbpaoc:k-
gafrieorveublnosdrneolfevceoolrnsgcaenn(it0cr-0a.tf4ilounpoprmio)nf.e FCinA-r1e4ta3hse iwbshaecirknegrcotohumenpdleimarpgalcnoegyeeweiastnhdhawovhueerrebprloot-ohde
vSiisginoinfailcanatllorwiasbkleto extpheosufreetusl.imit of 0.01 mg/m should present no
Ki
ocTTEn THINGS Fon BETTER Living... THROUGH CHEMISTRY 000164.
Lm ,
Bry vm
PERSONAL & CONFIDENTIAL
MEMO TO: H. E. SERENBETZ
-2-
April 10, 1981
J. R. Gibson, Director of Health and Safety, concurs with our conclusions.
CFR/BWK/bjd
cc's to:
WCE J. R.
F. E.
A. L. A. C. G. A. C. C. J. T. J. L. R. L. H. E. B. C. J. G.
TATUM, ADNN, 'D-9064 GIBSON, ADMN, D-9058
FRENCH, JR., C&P, B-17249 DADE, F&F, B-2202 HAVEN, INTL, D-3047 HAPKA, LEGAL, B-13373 GRIFFITH, PHOTO, RSQ-210 SMITH, PPD, D-12008 STOWELL, PA, D-8112 RHODES, FIBR, N-4448 SIMMONS, JR., CRD, D-6036 McKUSICK, CRED, Haskell AFTOSMIS, CRED, HASKELL
2
1D090082
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Revised 5/14/81
PERSONAL & CONFIDENTIAL
C-8 BLOOD SAMPLING RESULTS
Births and Pregrancies
:
PinPMBCl-o8od
status
0.45
TNroarnmsaflercrheidldou-tboorfnFJluunoeroc1a9r80b.ons 4/79.
0.28
Normal child - born April 1981.
C
0.078
NUomrbmiallicaclhicldord- bbloorondAp0r.i05l5 1p9p8m1..
C
1.5
Five months pregnant.
0.013
Five months pregnant.
2.5%
CUnhciolndfi-rm2epdluesyeyeaanrds.tear duct d:efect.
0.048
COnheilndos-tr4ilmonatnhds.eye defect.
*Cbuerfroernetprbelgonoadnclye.vel - in fluorocarbons area only one month
RDI:ldr
EID090083
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000166
hh
sa
Revised 5/14/81
C-8 Level - Current Washington Works Female Employees Number of Samples 56
:
Range .0.013-5.1
Average 0.92 ppm C-8
Number Above 0.05 ppm C-8 53 ET a
w ow ez % v 35
C
ww g30 % vw 29
C
ww o40 vv 28
RDI:1dr L
3
EID090084
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C
C
e C-8 Level Locations Other than Washington Works
Location SaNom.ploefs RPaPMngCe-8 APvPeMraCg-e8
Wilmington Haskell
32
EY
wD
9
ND - 0.030 0.007
Chestnut Run 15
ND- 0.043 0.006
Spruance
27
D- 0.070 0.027
C
Fairfield
5
ND - 0.048 0.014
C
Toledo
7
ND- 0.014 0.003
Circleville 10
ND- 0.030 0.014
RDI: ldr
{
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>
EIDO09008S
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