Document QkYwYRnoydO0wgQg0Vj3MZnp5

s-c: c; E. I. dj Pont de Nemours & Company >.COi*^Oi**rss Wilmington. Delaware 19893 CHEMICALS AND PIGMENTS DEPARTMENT Aoril 21, 196 RECEive-u APR 2 2 1981 8urford W. Culpppr, M-D B. W. CULPEPPER, M.D t~ LT '*** 11 PEADLsT- O STAXLAPLS ^ $>VoU ^IL ----------- ------ -- rj~ ?he attached letter from A. B. alrer summarizes the i wc ccnce 2rn s I discussed with you last w T For 19 61, there is ar. L'/ M-?.av Associates for Wil: irr.a litres rea sites thatydoes not apoeaj* t parallel any likely increase in pulmonary patnoiogy icdss.-;, we have at least two cases where pulmonary specialists do not contirracrffcAtl? reported x-ray findings-. -- ^yv. We are concerned that_, if we are accepting insignificant findings, trav .needlessly be i:tcurrir." fir.an.ei aL V iab ' ' ' rt.n examination or data from some or zu? ^differ darts indicates ar. exceptionally low level of recorded abnormalities. Grasselli, Cievelar.: Last Chicago and Memchis together found only two ahr. c rm. a 1 _ _ - c s i r. their rich risk aretes of 1000, ccmoared with about 25 each for tee sane size c-routs at Edce Moor and Newncrt. i- 2T9 the irsciclocLst3 these / c -* *- sufficiently critical standards? 'mo a CwVll-- We would like to suerges ..a round-robin ratina, arc; standard -- say 1LO Grade 1, or anv otter "ou sucres t, selected x-rays which has u:ee.n rrevicusiv reac hi gr. incidence sites and for lie. w incidence sites, found, we can assess what steos to take. -- or even review. --- . v'--- It would seem desirable that the mathematical criteria comparison be determined by the eDidemiclcgy section to er.su statistical significance. Furthermore, it would seem desira: the grout of radiologists include, in addition to X-Ray Asso such well-known laboratories as those at the University Host Pennsylvania, Cincinnati and Vanderbilt. tes , Is c f DUP 1153951 DU 062179 U,'U u afloat m 2- In view of the forthcoming extension of our screening program, I feel a particular sense of urgency in obtaining assurances of quality control standards for our x-ray readers. C&P will be glad to cooperate in the selection of x-rays for screening. Because of our unique position in relation to this roblerr., we have a major interest in the outcome. Perhaps you could iscuss Medical Division's reaction at the next meeting of the Asbestos oordmating Committee. /C. / F. E. FRENCH rrr . - ^~ .ttacn . DUp 1153952 DU 062180 E . 1. du Pont de Nemours &. Company IMCOKPORATCD Wilmington. Delaware 1989S CHEMICALS AND PIGMENTS DEPARTMENT N_n !- H - - a :0 AluORMALI'IES Tne fcur C&D sites in tire Delaware valley are excerie"ci "arxe: increase in me ru~ber cf x-ray abnormalities reocrtec x-ra/ --societies. As ciscuss.ec, it woulo ne timely to review reason for f'is increase with-Medical ana to have them oeterm X-ray Associates are mim appropriate criteria a no tnese cri are tne see as useo o v cmez.racielccistc. c / ne o c 11 a: I- is a corroaris: cf abnormalities report ov the Delaware Valley sites ny year. TKe. rate cf <D O Discovery is up suostantialiy from 196G: Z% at Chambers w iuQ% at Edge Moor. It shouic be rctec that many of these as normal in 1980 ana that the raciologists also report there nas oee *u nii.- 'C orange from previous x -- z a v s 'citicn has icresseo. i 5 u n 11 e _ y Actacnment II snows tne results cf me asoestos corsen.i"g orocran except for the urn t plants w.nicr. cata is not yet available. _t appears mom this mat we ..stil^ nest to fine an eximi nation rcr tne .nig.n "enters in tne Delaware valley comoareo :c if rest m 'me Comm. As pointeo cut aoeve, tne first step would oe to insure met there is reasonably uniform reading cf x-rays oy tne contract raciclocists. 0UP 11539S3 DU 062181 Ascestcs-Ae ` C"7Q 'cers ivcrKS Abnormalities - A7 Benign asymctcmatic - In Benign symptomatic it i'jr.z Abnormalities 31 Benign asymptomatic 21 Benign symptomatic Q : Mccr Aonomalities Benign asymctcmatic Benizr syrriptcrnscic 9 -w- v <3 -- -- .iCi Benign asymptomatic Benign synetonstic - 1 Dericc InEC 136 A5 11 - 26 11 2 0 3 1 13 A 1 Z `s, i. y 59 37 *Z 16 7 0 1G Q i 7 3 vn vn '-I [' O n> /c* OUP I 153954 DU 062182 jaiiMiy C' an on* ~ ':cn-**-a<*'*- U57 i ri - -= fltrcr^al X-TSVS ou l~a~rers ..crxs "c2c-"C Ezce vccr ~e_islc '.iarsra Tails wC^nscnvi-*c leer c=r-; -arss -ixver vc'2"lS - 5 *' -- - " *" ' -- - "icrirs rturt-a^c 242 73 28 22 20 13 12 2 2 1 1 ---- ru- 0 0 0 i C -c- i 4l4 Diaeresis Inccr^cie* ~ Du -mt ExDosure Benign Bsnien Asyrrerom3``.ic Svrr.Dronatic Nen-Ocr f-r Execs-re 77 22 Q 7 i n 5 0 0 0 c_ nu c 0 n C*") 35 11 q C c 7 C C n W. 0 c -n 28 10 2 2 1n - 0. 0 0 0 /*> r __s_. . 0 0 {") 43 2 6 4 j>. --13 n 2 2 r* -- c 0 r*, 119 159 43 53 - .c _ U-*.;=-A* n- r.l; C.--A ::: '' z A-' ?ZZ rr ,, ~ - -* 7ZZv no DUP 1153955 DU 062183