Document QkR612D7YGa1gR171BpyR26k

O 10 MONSANTO CHEMICALS LIMITED INTEB-OFFICE MEMO TO: DR. J. W. BAKRJi'iT (2^UABON, DATE: 30.6.491 C.C TOj J.A'. FBOMi u. N. S t r a o h a n . subject: AROCLOR TOXICITY M.N. DREfFr Ec Rn Ev Nu Cr tEr :. i mMNn SM/GvK SCTMt/ARY OF REFIR HtCES ........... rrg. Ho a d e q u a te summary I s a v a il a b le on t h i s s u b je c t. I have attem pted to summarize th e fa o ts a t p re se n t In our possession. X. M.C.L. STATKMKCTS. As f a r a s I know, we o n ly p u b lish one te c h n ic a l s e rv lo e b u l l e t i n on A ro o lo rs (02) and t h i s s t a te s : "TOXICITY - P ro lo n g ed ex p o su re to AROCLDR vapours s i l l le a d to system ic to x lo e f f e c ts . However, th is Is not s ig n ific a n t except a t high tem peratures and then norm al d ra u g it v e n tila tio n w ill remove any r i s k . ` A cne-form s k in e ru p tio n s may a r i s e from' c o n tin u e d b o d ily c o n ta o t w ith l i q u i d AROCLOES, but normal p recau tio n s and, IT necessary, su ita b le ^rm an ts provide adequate p ro te c tio n . Toxic e f f e c ts w ill follow considerable o ral In g estio n , but th is hazard is u n lik e ly to be enoountered". I I . M.C.C. STATSMSHTS. (A) m e most u sefu l statem ent Is given In B u lle tin P115 (page 19) under th e follow ing headings: (1) Dermatology (a) A ro o lo r 1254 in P.Y .C. film . I . (b) A roolor 1254 alone. ;($ ) A ro o lo r 5460 In p a in te d fa b rlo . (2) Treatm ent o f burns from hot A ro o lo rs. (3) T oxlolty o f A roolor Vapours. k WINS Q95Z0U E (B) B u ll e ti n P I 34 (p ag e 5) r e p e a t s lf t and 1 (b ) above, adding a l i t t l e d etail* (C) B u ll e ti n P15E (p a g e 71 r e p e a t s 9 above, and adds d e ta ils regarding l(o j. (D) B u l l e t i n P138 (p ag e 4} r e p e a t s 1 (a ) an d 1 ( b ) , and then d e a ls w ith problems a ris in g in th e use of A roolor 1254 fo r th e m anufaoture o f paper d rap eries. (X) T eo h n lo al B u l l e t i n s P 1 2 4 , 126, 128, 130, 191, make no referen o e to to x io lty . (? ) A o l r o u l a r from P*G, B enlgnus to P h o sp h a te D iv is io n Salesman (d ated 9,7,48) d e sc rib e s th e use o f A roolor 1254 as th e p la s tl o is e r In a com position fo r sealin g oraoks In g la s s -lin e d tanks used In th e brewing In d u s try , (G) A ooording to our p r e - p r i n t o f th e p a p e r on A ro o lo r 1 2 4 8 ,w hich h a s now a p p e a re d in In d , E n g . Chesu "An I n d i r e c t H e a te r f o r U n it C hem ical O p e ra tio n s " (MoArdle, G a rre tt, B enlgnus)t 8 and 9 above a re re p e a te d , w ith some f u r th e r d e t a i l s . I l l , GJMJEHA1. UT-fihAxUhR. (A) H eferen o es a r e made by P en n in g (P a in t Technology 1036, 1, Ho, d, p.231) to th e to x io lty o f A roolora b u t t h i s d a ta would ap p ear to b e in c o rre o t in th e lig h t of la te r publications, (B) P ap e r o f C.K. D rin k e r J I n d , H ygiene T o x loology, 1939, S I, 155 - This p u b lic a tio n d e a ls w lttfto x lo ity o f ArooTor rapw ttrsj o e rta ln ly i t must r e f e r to A ro o lo r 124B, (C) P ap er by x* Soh e a r ts and S.M, P eek - R e p rin t 552 from 17,8,A . P u b llo H e a lth R e p o rts Y o l. 5 9 , H o. 17 (A p ril SB, 1 9 4 4 ). This d eals w ith Dermatology of A roolor 5460 - P atoh t e s t s on fa b rlo s tr e a te d w ith A roolor 5460 and an alk y d r o s in . . MONS 0 9 5 2 0 9 3 (D) " I n d u s tr ia l Hygiene and Toxloology, P.A. P a tty ( I n ta r a o i e n o e , New Y ork, 1048) V o l, 1 , page J.97. Toxio lim its o f v a rio u s d u sts and fumes a re given, inoludlng ohlorodiphenyls. M. N . gTRACHAN, HUNS 095210