Document QkO7YwEOE8ezXVRkmB4nY6JGR

1 i I'll ill IJj 1] 4 i5 *< 1' U -j to asbestos for 25 years. The other was o a man of 50 with squanious-cdl carcinoma who had been exposed for 22 years. .Both had metastases to the pleura. Since 1941, a number of similar cases has been reported. In 1942 Homburger19 reported three cases in men 45, 43, and 49 years of age. In two, squamous-cell > carcinoma was found; in the other, an anaplastic carcinoma.- One had been exposed to asbestos for five years, another for 20 years. The duration of exposure in the third was not known. AH three had metastases. In Homburger's laboratory from *V.p.*V 1918 to 1938, in 4,137 autopsies, asbestosis was diagnosed in eight cases. Pulmonary ^ carcinoma was found in four of these. Wedler11 in 1943 collected 92 postmortem reports of cases of asbestosis from :.f different parts of the world and found an incidence of 16% with associated ''J; pulmonary carcinoma. . In 1947 MerewetherlJ reviewed the accumulated data over a period of 22 v' years (1924 to 1946) in the "Annual Report of Chief Inspector of Factories in v England." In 235 cases asbestosis was found, and in 31 of these pulmonary card-' ' noma was also present, an incidence of 13.2%. The incidence of pulmonary V.'i; ^v \" carcinoma in the general adult population was 1.0%. v-i' Lynch and Cannon in 1948,11 reported that among 40 cases of asbestosis over.' ; a period of 18 years in.their postmortem series a total of 3 cases of carcinoma of '.yr.! Er the lung was encountered, an inadence of 7.5%. Each of these three cases showed ' . i'Y!>V* v 4' r medium to advanced grades of asbestosis. Wyers in 194914 reported on a series of 115 cases of asbestosis. Pulmonary earemoma was present in 17, an. inadence of 14.8%. Squamous, carcinoma was present in nine cases, oat-cell carcinoma. in five, and columnar-cell cardnoma in one. " Af BEPOET OF CASE I>. I_, a white man 40 yean old, was admitted to Queens General Hospital' complaining of cough, fever, and weakness of two weeks' duration. For four to five months prior to admission he felt weak and slightly anorectic,jivith a weight loss of about 10 lb. (4.5 kg.). Two weeks prior to admission his weakness became more marked, and he began having a dry persistent .cough which was nonbtoody. He visited his local physician at that time and was found to be febrile. A roentgenogram was taken, and he was told he had viral pneumonia. He . wat treated with penicillin,' sulfonamides, chloramphenicol (chloromycetin*), and aureomycin without a fall in temperature, aqd with persistence of the cough. His local physician then advised hospitalization. There was no history of previous illness. From 1925 to 1940 he had worked as a plumber but did not use asbestos in his work. In 1940 he obtained a job with the Works Progress Administration as a pipe eoverer' in which he worked with asbestos exclusively for one and a halt years. For the next four and a half years he continued to work as a pipe eoverer in a shipyard, where he again used asbestos oaly. During this time he was told to wear a mask while working but neglected fo do so ., and complained that the smell always made him sick. T/>>3 -J /' tq . -is* . '. v Alt . t/10. Homburger, F.t Ca-.tncMcr.ec of Primary Carcinoma of Lungs and Pulmonary Asbestotis: Analysis of Literature and Report of 3 Cases, Am. J. Path. 19:797-807, 1943. v- 11. Wedler, H. W.: Ashcstosu und I.ungcnkrehs, Deutsche mcd. Wchnschr. 69:575, 1943;. abstracted. Bull. Hyg. 19:343. 1944. 11 Merewether, E. R. A.: Annual Report of the Chief Inspector of Factories, London, , 05*. Majesty's Stationery Office, 1*147. l E3L Lynch, K. M.. and Cannon, \V. M-.: Asbestosis: VI. Analysis of 40 Nccropsied Cases, DiL Chest 14:874-880, 1948. ^ M. Wyers, H.: Asbestosis. Post-Grad. M. J. 25-.<131-638, 1*149. Physi. lying in note witl lung. T Laid blood pr per 100 polymor; were wit . cells. 'A A cfc oval that A bone parietal urograpi findings. Thro On the i of the ri A spinal The cell 10Q cc. on the i (methylwithout day. The onknowt Posh pleural : yeltow, : these no rigiit lanecrotic Inter addition, dark red gross, bt pole of t rouaded, Sereral In ea small he surround In tl measure The .'/ien shape, Y regular manner were no Typii and out: . Meta inciudint rm.$ Ipmi V. '. II. I&I fY:*.