Document QgwrKRYKEN3KXjjMze7a2XnB8

"PX ~2L!b (o & MK34-/2 The coxic effects produced by PCDDs and PCDFs vary quantitatively and qualitatively among different: species. Uichin a given species, che effects produced by che coxic PCDD and PCDF isomers are similar co chose of 2,3,7,8- TCDD, differing mainly in Che incensicy of toxic effect. In all laboratory animals che lethal effect is slow and ensues days or weeks after a single dose. 2 T* The Yusho cases provide our only data on the human toxicity of PCDFs. Yusho disease was caused by ingestion of rice oil accidentally contaminated with PCDFs, PCBs, and polychlorinated quarcerphenyls; as such it is difficult to separate the effects of che various toxic principles. The clinical symptomatology of che Yusho cases is presented in Table 10. The Yusho oil was clearly fecotoxic. potential of PCDFs in man. There is as yec no data on the carcinogenic 3y MONSANTO EXHIBIT 3418, Investigation of health status of Monsanto employees at Krummrich Plant at Sauget, Illinois. By Dr. Webster, et al (October, 1985)