Document QgRjbE7aLRa3mgbaqqOjnR6YL

IN REPLYING, ADDRESS THE In d u s t r ia l i g i e n e Resear ch La b o r a t or y FEDERAL SECURITY AGENCY U. S. PUBLIC HEALTH SERVICE Na TIJNa l INoTiTUi'L U* oH^oTH dET-xL D. 14 , liaKi'junii) December 10 , 1945 Dr . Rob er t A. Kehoe Ke t t e r in g La b o r a t or y o f a p p lie d P h ysio lo gy Un iv e r s it y o f Cin cin n a t i Cin c in n a t i 19 Ohio Dear Boijr. Th is w ill r e p ly t o you r two le t t e r s o f November 9 , 1945, which we d is cu s s e d a t t h e r e ce n t m ee tin g o f tn e A3 Su bcom m ittee in New Yo r k . With r e ga r d t o t h e p o s s ib le v i s i t o f Mr . R. P . Lowe o f Pr o p o r tio n e e r s, I n c ., I s h a ll be very p leased to d iscu ss any m a t t e r he h a s in mind w it h r e ga r d t o t h e u s e o f DDT as an in se ctid id e . I sjm a t t a c h in g a cop y o f a l e t t e r I s e n t to Dr . P a t t y l i s t i n g proposed p a p e r s p e r s o n n e l from t h i s La b o r a t o r y cou ld p r e s e n t at t h e coming m e e t in gs o f t h e v a r io u s In d u s t r ia l Hygie n e As s o cia t io n s in A p r i l. You 'w ill n o t e t h a t n e it h e r DDT n o r xy lid in e were m en tion ed a s t o p ic s . As I in for m ed you a t tjhe ASA m e e t in g, we a r e now engaged in co m p ilin g a s one b u lle t in a l l t h e work we d id on x y lid in e . When t h is i s com p leted we p r op ose t o a s k fo r cle a r a n ce fo r p u b lica t io n a s a P u b lic H e a lt h B u lle t in . As you a r e a w a r e , s e v e r a l o f th e p r o fe s s io n a l p er son n el o f d iffe r e n t d is c ip lin e s were engaged in t h is s tu d y. Th e r e fo r e , i t ta ke s co n sid e r a b le tim e to co r r e la t e a l l t h e in fo r m a t io n in t o one b u lle t i n . The co n d e n s a t io n o f a ll o f our m a te r ia l in to one short paper fo r p r esen tation would be r a t h e r a d i f f i c u l t Jo b , b u t s t i l l more d i f f i c u l t would be f a i r l y e s t a b lis h in g t h e a u t h o r sh ip pr oblem (w ith w hich I im a gin e you h a ve had some e xp e r ie n ce ) . How ever , some member o f our group could p r e se n t and d is cu s s our fin d in gs in th e d iscu ssion o f your paper. Kin d e st p e r so n a l r e ga r d s , Sin ce r e ly yours, c? Pa u l A. N e a l, Me d ica l Dir e ct o r Ch ie f, In d u s t r ia l ifygie n e Resear ch La b o r a to r y PAN: clb Attachrae h -7 * Q 0, 3 \ O n -.h is t r ia i H y je n s Dse ^ r u h La b o r a t or y ..**\*^* *~Z** iX i * `JX j^m 'Ju X X-^| mwaavXae-rwji^ So ve a is r 6 , 1945 Dr. J. A. P a tty Chairman, Program Cosasi t ts e Aa e r ic<ta In d u s t r ia l Hygie n s As s o cia t io n G 1e ra l Motor C o r po r at io n 435 3 . L ilv a - x c e Avea u s 1 :l'o it i , Xic -i^ xa . Dear Dr. Po tty : Dui s *iiA Ackn ow led ge yo u r l e t t e r o f Oct o b e r 3 0 , 1 9 4 5 , a s k in g fo r s u gge s t io n s fo r toe program fo r t h e n e xt co n ve n tio n o f t lie ..imbricata In d u s t r ia l l y g i e a . As s o c i a t i o n to be o e ld jo i n t ly .vit a t n Aa or ioon a s s o c ia t io n oi* In a u s t i U d rdys iciuUiJ and Du r s s b a a , Pu s Jo t io o u l Co n lo .-sn cs o f Go ytr n u 1 ,,d u x r ia l H y g is a is s k , fa * I n i u - i r i u l .lu r e s , u n i la iu s t r iiu . D e n t is t s , a t th e l o c a l Dh yr u u a, Ja ic u ^ o , .p r ix 3 th to a p r i l i j t a , 19 a o . I -e ve d iscu sso'! your i j t t a r Alt ! s e r e r d of uy ooiieu xuea in t h e Ld lo r -it o r y and I am g iv in g below s e v e r a l p ap er a which could be p r e se n ted on work o f t h is La b o r a tor y i f you so d e a ir e : (1) ''T o x ic it y and .P o t e n t ia l Dan ger s o f It h y la a e Di a id o r i d e , " b f ? . A. su r geon Leon A. -ie p p e l. The re as been a gre a t in cre a s e in the use o f e thyle ne i i e n l o r i d s both frors ta e us ual i n d u s t r i a l s ta n d p o in t, as v l i as an l n s e c t i o i d e . The t o x i c i t y and p o te n tia l dangers o f ethylene d icu lo ride to se ve ral spe cie s o f animis fo llo w in g lo ng continued exposure i s discusse d. (2) P o ly n e u r itic dyniroms in Occu patio n al D is e a s e s ," by ? . A. Surge on 9 . I . Sie v e r e . 'Is u r i t i c m a n ife s ta tio n s are becoming mors and more im po rtant among i n d u s t r i a l workers who are p o t e n t i a lly exposed to various chemicals. 4 general discussion o f th is is givsa s s v e i l as a re can t s tudy by t a i s Labo rato ry on p o ly n e u r itis among employees in an a rs e n a l. (3 ) "The Ap p ra is a l and Pot a n t l a i Dangers o f Pe trole um s o lv e n ts w ith Sp e s i s i Se fs ro n ce to P a r t i c l e 3 1 z e ," by PLa ra accd o gia t Jo s e p h L. Sv lr b e ly . The in cre as e d supply o f ce rta in hydrocarbon m ixture s r e s u lt in g fjrom th e crack in g o f high o ctane g a s o lin e has mads suoh O 2 n n t t r i a l s a v a ila b le on a In rge s c a l e . The t o x i c i t y and p o te n tia l danger* ol' p r a c tic a lly a l l o f th rs have not he re to been re p o rte d . The use o f such m i x t u re s &a s o l re nt fo r DDT and o the r in s e c t ic i d e and t h e ir uae as fi n e a i a t and ae ro s o l po se s a d i f f i c u l t t o x ic o lo g ic a l problao. ( l ) "Vo la t i l e Hydride s o f To x ic o lo g ic a l In p o rta n ca ," by Blo ch*inn Mtawart H. s 'e bs te r. Vothoda o f p re p a ra tio n , uoe o r o ccurre nce in in d u s try , re ltjtio r.ih lp a between t o x i c o l o g i c a l e ffe c t s and cu e n ica l pro pe rtie s, acute vs . chronic e ffe c t s , the newolytie :./ :lrdd*c, T'i n i r a l le t h a l do s age s , v o l a t i l e hydride s as problems in In d u s tria l to xico lo gy . (5) "The Acu t e and Ch r o n ic T o x ic it y o f Wa t h r l Ch ^ o r lle fo r Laboir utor :* An im ils ," bv P h y s io lo :i-3t V. *f. *p it h . Tiierb hoc been a r rr'ral Im -e i s e in the In lu a t r i e l U3'i o? nptiiTl ch lo rid e during th e nnv. Muffle -le nt l u fo ^ n tio.ni Is no t -tTo ilabld in the l i t e r a t u r e to d e fi n i t e l y d e fie s s a fe wortria;? co n d itio n s fo r e th y l c h lo rid e . The re s u lts o f a study e xtending ove r e pe riod o f bout thre e yu-rs w ill be discusse d. (6) "A itn d v o f the Effi c i e n c y o f " thoda fo r Obtain in g Vapor haaple a in A i r ," by Sc i e n t i s t {P h y s ic is t) H. L. Andrews, Jr . Ch e n is t Dorothy C. Pe te rs o n , and As s o cia te P h y s ic i s t i i l l l a * C. 'Smite . Pre s e nt day a n a ly t i c a l proce dure s aave an inhe re nt uccurae y co nside rably gre e te r than tant o f the s tap lin g methods. U lt r a T i o le t s pe ctro s co py and rase e p s e tro a s try have been used in the a n a ly s is o f a i r co le s co n ta in in g benzene and vario u s d e r i v a t i v e s . The r e s u lt s o f the s e as u re ce n te are analyze d in te n s * o f the methods used to o btain tha saaplaa in ce re iy yours, )7 Uv V (UA !A I '^v.v \ Pau l a . Re a l, Uadi c a l Dire cto r Ch i e f, In d u s t r ia l Hygie ne Ras e trch Labo rato ry PAR: clb CC: Dr. Townsend Ur. Blo o n fle ld n7 1oH \ '\