Document QgGBYjX6r6QMq5kOGEm7BQoV7
REGULATORY TOXICOLOGY AND PHARMACOLOGY 2 1 , 211-215 (1995)
1Talc: Consumer Uses and Health Perspectives
Bethesda, Maryland, January 31-February l, 1994
Co-Sponsored by:
The International Society of Regulatory Toxicology & Pharmacology and The United States Food and Drug Administration
Rapporteur
C. Jelleff Carr Professor Emeritus, DepaUrtnmiveenrtsoitfyPohfaMrmaraycloalnodg,yBaanldtimExopree,riMmaernytalalnTdh2e1ra20p1eutics, School of Medicine,
Received October 1, 1994 WJGJJJTJSWCADGDACCCCHDRMMEPWKKDoMKKAOOEoorH.Eaoaorhdhhaoaaaaaeen.tkiMiSSiAihhJUoNRccntltvbrlayornbnnrrsDEEEDNnnnEBrlhhyhGlhIoIeriimnrelinLPPSnFSsa,eaiSiioaraienaallaaHHaLEeDAcTaEteBlniBDpvdrtSeeonEtDtimEOml.osFlooMaAaAelElCLiWzPtdBha.F.BPBnptLaouFnRk.g.tvEHFDa.CDDCHhrea.e.rAsJrlaAapeFFeear.BH.okEeCE.rrBsoiBelomUzLtJnrrdeLlDAiUuRHrewlailP,nFi.arErcrSa,,eeLsaaoRauaDlTapsa.iaLTIrBotceiDTy,Rl,mn,pSEgioch,nhsKCJlI,uurrEowdoh,a.UaS,NaSS-ehg,eotceOzG,W,oelsU,tRnNE,iSntvD,,.en,syoliHSaPWlSaiHUCtp,L.G.noEihC,,eISUescn,nuS,.tsfpoUE,ECosa,SiTnUiieydmuloU.k,T.etF,eze,RUilKESciH.tho,,MseJweduocnnFrhSvaoo.D,.mIseS.roAUgdhmKfeit.e,toSkSorUeCte,viF.aheasMremgJyedf.F.Phob,amleIltPySninsFoineoraidinctrlFerrio,&RiUi.nioa,oCsrsohTi,toCcc&srvL,orookRydeIorFsoCiin.neEhceoCIUndDaooy,cisct,ndenlotoriiasl,yl&ed,Dt&afaumoe,vgNRaarnscoeoofMla&r&ndo,leuKia.rvI&.rripKndregStr,Denvekrf&gDiEunyimJaco&w&asDJlsasCrnceg&,rW.oDnh&nrerAtioD.nrea&uGrleCti,gaDuyGARsaYrhyrDnsdCtJuiTg-el,gDSnaiusoiaraPdeoanesuomgPptoroSrckmtSgAm-lyyswAmramirsaathurnosco&K,Aiat,knhodnpbplArSnomgMndhgnbNi,nmoTeAoda.iolnmancuoioSsmls,deeAgfNltsfeemeenmhsnooediioiodltmPiCltndscgiwsdNsCeg,oilne,enrlCrsni,t,eihnoierminosaowodirvoMacCWionsNnPriTJ.svICr.naiselt,a,f,nt.,,niittosoieio,atu,eosntaosrosllPoYCgCtcrMClNrliblurdCtmarrofrsionoPa.neCsourksoao,aamihitCertPegeis,ntra,ncibo,thicenlanlitiSwlsuriykouauae,OlncticvounNedncWcaRioiomCrmnnbloiigtstcnooaeiWhlntoeeuhnYl,cnS,lataiecP,btniCirHnseoroe,,taoocncIrratsiC,o,hr,aotnrWinaownhrhaeRshoVcuHP.Ktk,Nc,lFWoC,i,ahtPaiudoriain,i.r,onDCeaMilrce,y,SteucWWlsoagtnNlagaenaOw,hnkhacNCA,Odstgalsiisvateoit,irNhnthuMn,teNesnranhihowsnoAYiiil,cfyrweisLsgaohnll,ia--,no,tolietetwItaisgnaClNdYo,n,roDnlN,aYnatdnEkicnoniDJgoMesnCIseot,d.ep-r,tywnon,iCtwroSkNanria,cn,kDSdnsagr.,,Ke,YD,keeYC,yl,wGNemoiyalWSoCDlMamrnelkreiJmkniCooksiwies,,dlrac,lcarlogNNhsmNosnYigieaone,gaeoyywsrawnrNitBknn,heYrYNwaCooneraJrwckrkehorJ,lsieenWryasaesyhing
and1PHreesaelnthtedP*erisnppecatritv,east, tNheIHIn, tBeernthaetisodnaa, lMSDoc, iJeatnyuoafrRye3gIu-lFaetobrryuaTroyxi1c,o1lo99g4y. and Pharmacology/U.S. FDA Workshop on Talc: Consumer Uses
211 All riCghotpsyorfigrhetprod1u9c9t5iobny iAn0ca2an7dy3emf2oi3rcm0P0r/r9ees5ses$r,v6Ie.n0dc0..
212 C. JELLEFF CARR JTJJJJAJJJAJGGSBGKSCECJADATDDCGRFEREMSKFLNKMMLBRBINPLRRSWDGDMMRMGRBMOEOOaEOOOaTHCTaTHOLEAaaaoE.Orr.O..odrlhliorroeooruriaeaoAeeiFAnaaSaaOHliHnHHHAacyOnEicEOFOOONaWaarPWrwNuukaRNrbuRvnBotignNbnFntwlnrRElrrrNMhdRrlNNPkNNNNPiTMoFnonnNiMARMirnhcRDChlecaoEieBIeieaacjaT.cPIyTrnvjnHsikyanHEan.TFLdiLAkklaliGepraLRrYesouEcOktEPHeol.MAHllICAeAWDaH.eiLDRrGEElBELPNyAMtnDtCYrTSrdGERdLdrerFRNGRlnSTSSiVSJC.mSO..MdlaRHEY.NMNISo.cneSori..dmnC..iEacPAT.cETOeLaJJooTMDc..YoKPOLOJre.CFhHEWLWrGMtEpGio.ApKSnH.N..EEGRa.MneBMmT.WD.ibScu.sr..rrLsM'L.Gaik.reaabua.RdoTPwSMWiHaI.pMWGSrT.eL.geeVe.ey.LJooiigoRA.L.SMlLoLpHMNreEinnesEH,m,noSVeDoKhrAcGtnrlMnooel.HHMlenGolEEueAlCHcecSaTiRHCEeornKNogT,asoGrhCoOraaisoEEsokuaDe,Lbnsne,rTNRen,iTMdtiOHRsCnSHdLedaet,,aiehaoTslveardeRtRyFugUlts,ianlbRlMgE,,lerooeW,s,AemTKsXCHLtsNNh,RedrAnebA,rFJ,danesoylSJSsG,a&ehTaLOn,nstsCGha.rrt,,NItueIrUR,,T,oyaiEmTNorEerSlMEeeL,e,he,tLlseHMr,t,,HztthnwCCteeRnbde,oBziCiG,n.hUlR.orsRA,ynshLN,,l.gfruIFJUslalne,.aUyteUeeeNzoKrrCsSl.Oeg,ot,clirUTnt,Era*tfoeFT,Nw,,,uuza,U,v.,onrmeniU,c,n.,ge,.aCbOoJE,TJPa.nSC.,,eiPneMse,ST,hPsahNB.mzUotnSSoS.haenomDUmTSIn.lL,M.,oobStGsoseiS..S,n,hUC.rNeoroSlroe,nthon.eacSn.ciinn,oEBb,Vu.SshtakoCt,UhhL,.rnEntooigabnLeenFe.S,dUBhorJ,ns.tedi.anscFpaFnCRiYmlPTdeMrrahSnUnomcPaaucgreieFsuoTTe.axUylounotk.FPtIu,CFr&vpit&nyo.,ouGu,nctli,eu.hreersIcnzirxnenygSrnaee,osoPli.heoAeFeeteroooroUIoPoonoclmoeSodPrlvetloroeWoNKuccSFl.oihs&drdgGeyA,JdTneiretrSoodlmdatnD,nccClio&.esesnUlrd.shn.acrndicbstaiKa-s&loiosovFirad&se,oSC,,mmttlrrcareac,deeecicIoClurn,,&&FeirnhceiEsaoemucoUnhwo&ndb.ysno&aJysSOitsBataRIilcao&l&uIocer,rerftMuroCdtmytlptliuniGbcvnnitlDocnoToFnuioelsleCRtgtie&aliCtvereCsDDalmoA<pc&Jeetisp.yUooatSyoDmcstdhr&Ygbrileiioo&Eafsne,coD&rirakeDda,aCo,otlceoAteto.rgrtmmruoeiUfce&oCnkuMem,nroy&vonoDe,eyrrlEivPnGnlaJnu,suhrIrn,Iirhneao&WIrnoLDdsrrisnugnEJrttsdnifeeemnanonTCuctogb,lCuglvovroniuiEviikonrBlmaiInomaeoglal,rGsdTcDgocntecmirylLnguValDoAga&hcet,neoifJhaeesInoomiD,yvnrukAerAn,t.huio.ahnrfLep-ngchvi,niAaoyitDlriu,nrRtl,i,e,mclNdporeegArAaClnciuImmgl,enseoboooTdraadcsCtiUu,ImDnperacnOCucsrnsSBaodCAmolMadrr.tTui,Mrinead.ldenginsf,momlmegtNs,as,ooAo,iliRst,gccueo.kugsncbm.rnaregonwdaoornttsi,mwmyNaySiNi,iE.trWco.nAStBhluoegeyielyoAKnNdftioe,tinailrtnrtm,aMm,C,nn'iay.ln,eIfinyAsnhanoaeisc,n,ededeg,sii,kor,arrWmmntnieCnstdnateM&eNt,oBYNnng,peiitMiristnorswgwiiiit,dfaiCuLHCnuIItrtIceirIasoso,Awsm.gzcCnoghtoiiUtsieioiiidoEgonlIle,nsnnemneat.yotfnmtHM,nohJrlsnsoConrnaledohoanrenNin,rerotdJrr,loclswciwcirra,aHtb.tYdonsCcciswonriB,lnevaakNsncntsa,or,ainate,e.ertrd.,brmLn.aDsCet.oositenao,yho,.pa,iN..yaC,llo,asaaprnrraottriuCisnNatFPgl,eVitRw6Rls,Yrn,YniiiostraAionluSrliANlasudtireoLttModlnYnneeo,owsatiPatnWeroEsMiaktiLeo,oaiol,itlIooeNgnmsaoaoCnetrsndrtrsniawoaloahootton,nnnIicericrroYaFctylratearaMMsoagln,anassnns,anJct,roegritiotkennknco,kn,dkPkhans2ennnstnowViriolratrhRt,twieoctswr,.rnC.ni,vkCWYn,,d,,eariaBteiirCtn.RGyasaear,.,donhae.arSOcf,eooiiiiDe,,as,tCaisNuN,ohoikPNsOlTnRnghcslooonosaLaliJon,hoBsa2nMurnattnlMtfsllrlcNnk,CEekarWnaoee.sWWroco,oeenefdscikeehnioimsgla,Rnko,tisaogCg,toytrxk,,ttmnseeyrwhcG,rnca,we,irsR,oW,ot,ciadnaP,onaaoyvatmdna,sdaktenNlWai,NMwsynCABonhopMChnaiesnicWclsesNsvunWWd,eiitMentlYvioOinsh,YaeuchskshietteeoyiBgalaooccnacsatwsoRaCMielcesYfaoiviw,iowsrioiaMhnhtltassalctAnrr,nngdnon,nowoniokseSCeosreiorarhisienohyD,rlisecgan,csggohnokrI,ls,tJlnkicaMhlprlrrilyoeiyoYdtln,auseCathi,lnCtietskkanIogsM,,issrCYloascoklonwon,ocdtniniBvb,aargisIvnlaeatGtD,nontrcon.nngoisrlMcoisgauiaiirntar,lNudnnellri,dkSulcoo,.te,igeCnyit'lrcraodsn,a,rkofRnoueeaoemnyntgDsloyehDDlrtinoSa,,EOorntw,iiir,,,l,aarueCconga,CCknnySi,MnndFfDMsrNhsinWgfilndyDkiaoYigDeallla,tAcaCediloaatoloaCnBelmCtrwafrnWrlnsrsdfyrimnydaakhd,olJald,ianiaaaoernVsn,nksnrSWhged,,s,NdLitreanoNRNm6eysgnoweheot,3cwowinUkDnJntvegG,JCYirtelDooslreernCs,kyeMy ary
TALC: CONSUMER USES AND HEALTH PERSPECTIVES JARAREWBERINneoFCiNvNlnnFHelSRaeAGriTElaRWl.dYmLDyWo.JYZZZ.WYloaaaWvLuyvzkeIERueanan,nIDldr-CUGsfOeiKak,Srna,CniKi,r,Uva,AILRe,C.rmSuErtUaes.zTeni.reTFStr-cnyiW,.oecaAooCracafd.PnolAMlM&saaHmmact.iDeeereeWayr,trniillucIcattonshsganlcv,CAdAF.e,I,condonCtrC,muciporIon.oi,nanldnlrcnTeaiaA.bsgh,tttluieirAlroorieaPanntyeltn,,,aaiFcorNDNneknoteae,,ar,wwykMI,WnvsGJi,caYlae.leMro,ersoy,rBhsrolkeaCgirn,nyinootaNgadontenkonlwaneyc,ntYD,icoNCurektw York
213
EXECUTIVE SUMMARY
dttcaogaoedgsooDtitpsecwetlPntsatitimiiir(ohonoaonitdahsnCeatporaxngvnnaiirrffeoyratarlgxsalsgfeeaecmfoelTynTenOApoidtdtsIcTrtcunhrsoccneildimiadalnnhb,aoaielwcsg,cchsguhumdauuitrF(fzdloeeotknulteFaadnyoeJamrt,cIidleesitfasomeeenbArisshovaceASmndaesxhfldeitrsvasneeldrmSpwtc1oarreaameeahlrewndinpe)ieeuaRindbgisoieded9sneogsloltoracgteessdnotudtcyuesdvicgio9maraTmcynacdesnnstrrefrgncpcs(,aiicnoi0aireopatiud,usdmerooaaNcouPenosoegatekbarotoiuldpfi.nmnebdalsltwnhnofnacrfycdUimttsn)yspfepsreTrel,cfowhyerswri.nkcdneiheuocroi,a-itteorfte.ruems.la3apenPaoceaShdmsoiAigoeneaolfndnssathsmnaccolrl1aejssntrepsre.f)ripgssAfifucuetivoelisiaennmwenann-nhrsditeftasaPeA.pttRfcsaotrsbokiFepohtocgsseweshdgtitheatpreneeteitiahcnelofrhieeivusheordreqsuloedceyspdsntfianftraarmjaasngro.esrcbuiegutedsrniytoetiosergborycltbeebustrtoourlhnnmsgrriaoaimspmufiiflooacewmuylnoTetuerpmnlcettaoh(ooiprlgeroricaaetgetaueebnssFsifeaaociahlaeraaafnrhhaithtcro,lavnrfilntfctsclrsolsDynptsoedcesrosieaaoaraaulhllriymatettpooetkcpe.,-sretotrosael,tsflcrAttssplossfhocyneptroececseisghv,gnunciat1ocpi,qidtaefoousev,tvx)stsooirasunieyh,hagcnTruhuano,usesessrtmnsileiefleDto(eeauf1dlelreptnmhsitwbeoaenavtelrtoCitaioohraoonre9thycfnerhlpleadsoixrltvwidoorifaiinanloeponoi9e.Teol,ebytnxaigefoeoccifdcetcoasawd.ct4tdolairninfsperigFJaehslogaahcetveyettootcfCgori/tFott.lneeuflhiitnwAesdocednkaaowolhyfmkgacsoiopbNrorhtdadoricoelonrslttfuen.)oiisinrvenouisetcsossedgulnnuhcesrn,cnuoahoduorarv,mp,eagulecgPgyrtegalaoeskatem,amfaewyssitndcreiiigrtliiidEbsttr/epchnpestssctiotitcvoaenghucouiueyholeuiyoshi.nstt,edoUnxnpnesnedcfouaowirdfhurlatanidnooorcenradiaBcaeoyedaasranlsy.senmDctitwaopasranSatntisgtoormlthneeesesaaooose,dpohrPfttocct.rfae.naas,Tsdeidxooybitdlfrar.ffaeeTtlonfhtncntofseayEeipneereoFctoottrlpototcenoiaeep.yogiptccnhheGiyroeexIompmfiroorfuacxrftttoiaoisiigEadneecrsiosoaroshzmaslhdne/pppecpnttgls(pmaiheatrmtldtfxdacasnaitovuFmceonsmdoeuecsneearoshstsntauutlptm,emadrfl,Digsc,aslrpdtreittciracsiaaaoseenicizoetilauonutuiittecedgoioessioAinnnnitnegaahetegrernrrncmtpaiandooiotiessirriltnlydddddgyogneeecssss-)-lt,,,ff
tcwcntocdtscccTqcttsSdUitttftgttolmfmilffifiaiiiuoaalnhhnudnhooououuaoooaohgeefuraclmoehellinamenrereaelrrhtlrnaalTtmmmyAfsanDrIicitclnroeotieemdtienmintdgehosetatlceRlsthminhhst,eosgrNgsretlmoens,adrdftcsrleteie.eneeeoe,hiuayeioireaeaifrwnn.tteadfancpnThronsrniidaiavadca,xoDtGmptnlnmysxtdpnlrUf--.ld-hirgynorrsltpoeeydpPolisyilueolsioorcriSyeimDiardHaecigeereapatrnnmirooo.nlarntmntnabsflmttnptvcbearcltneieildrorsghdneesiiugruabaBeoslinqiun.oesChfrnleovouyerbiseaaa,caus.attrtllyfcseeslhumthanoraaohnepRsraetd,mytissoaiOlccipotxtlsoeheetshutatnosouss,lan,oss5teuatoeuuhuuonpiapiaacclspaebsri,lnourtvgso0rottvndpoiparseermefsaosllsatae.zirrrintrettnse,eifftaifasethteinsoasuodshtaue0snaflehecriliciaeheiacirlaenynussticvmctnvno0dFrswudfnb.ooi(.elmthdnehoey.dretuditssn0eoFebndt3selnbddfaeyinIseenesoiIelsyClnudnrtnspSeDardan4eceuncttn,,irt.msocsfnbsttauemsantlolsaorafuo4oatcuNa.AauioldttttatisNdedtltdmhslftaneeaones/bschoeholirytn--wprepaenl1)csiToimNkumsaeDruniascrefeeaasladdeyeshps4,dmedbnfimgnoscsssmPrawsnreoeTeantmll-t(edaeoitettsvetp,t.yamdhainahassrtntRssthohgrohtnavcmPhvtiiitcaoa,itigeeaiolbdeagrocmeicwerGyradenmcinrioezskl,ttovstiogatmeuncarihthssreleeuhcttiNatonaetfwfnamidedrhetiatmgotaat(eddnehohoooairatepbohrasohgddeleMlflotpmeateftyealegnillnnprcorcsnfediatthnafeisilaadtgtnomneisneceha.sganoeayseeddeiuiTmnttnetrinttuiss.yorcnotntatlcvntrdaivestemadaitsiDmeepeouotlailhonclaBtIiooittsarttinhaanschonsafrnd1nnilrfrenniusneaocsnvlia6vuptnpNodedoaarcr9edgauntp)iloUdrdinr,acet--Ceiberhtzoeiln9nonhifbesahemroifTre(sctuesaprTieasn2enf.lecf3dodoviaiMtopngeaecsistumsotmottariPesitsFaornaoreapalnoyfaiielioobdtHvhNbn.ramlusoilsreiaxfrt1rahfnsaenenylnmgp,seocesrieitipesfn,npjibykTasretacosaiaeiosrhroficnotatmhtcabaraeffaonsereolablunnhoPniirdcsnairlooofaadniotlsabgseyfdtblnieneetaleuetiieprtortltfotcoydofotlsyaozsctcenscelBiiiotdtvsoetecTsetl--ffoochnfgfqate)onlcteiaeosoepeec.oweeohrooermtonyinteruofliseod-lrarvervraivnleanileoIinoenmf,idSaemcnooafoncsmnanteptfrtsairfPpccotlaetthhtblootconvtdvltutftneeicethihpiieaoittardtutaaalrhteeonoxoxetfeontashlhceereyriltaioatlnoloiecercatisrrtlinttliiinenoyngcdddceecsass-t.tlftf
214 C. JELLEFF CARR
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REFERENCE RoCtoh.m, Bano,stKon. .J. (1986). Modern Epidemiology, p. 17. Little, Brown &