Document Qg9vRJN9GGB9KQ4jeBE1r8Xr5

ALBERT C. CLARK VICE PRESIDENT TECHNICAL DIRECTOR MANUFACTURING CHEMISTS ASSOCIATION 1825 CONNECTICUT AVENUE, N.W. WASHINGTON, D. C. 20009 (202) 483-6126 ,a \ October 13, 1977 OCT 1 7 1377 F Mr. W. S. Ferguson Allied Chemical Corporation P. O. Box 1057R Morristown, New Jersey 07960 Subject: Vinyl Chloride Research Program - Continuation of Multi-Component Studies at the University of Louisville Dear Mr. Ferguson: The Technical Panel on Vinyl Chloride Research recommends continuation of the multi-component research program on "Research Techniques and Methods of Detection and Prevention of Carcinogenesis in Industrial Workers" at the School of Medicine, University of Louisville. This research has as its objectives the design of methods for early detection, prevention, diagnosis and treatment of those individuals exposed to potentially toxic chemicals with the aim of preventing any serious injury, precancerous lesions, or the development of cancer either on a short or long-term basis. The program is designed to identify, at the earliest possible time, potentially harmful chemicals and to lead to a reduction in their exposure based on objective chemical data. Simultaneously, research is being conducted at the University of Louisville on the problem of vinyl chloride toxicity and disease developed in animal models. Studies of these types are of key importance in testing the potentially more effective methods of detection and/or treatment. Among the important phases of this overall program is the evaluation of immunocompetence systems of individuals with both short and long-term exposure to vinyl chloride and other chemicals. This evaluation is designed to aid in identifying o AS1 000014668 defective or reduced immune surveillance prior to the develop ment of malignancy. The cost of continuing this research through fiscal year 1977-1978 is as follows: I. Clinical Immunology II. Clinical Biochemistry -Enzymic Systems III. Clinical Biochemistry -Biochemical Changes IV. Clinical Pathology V. Microbiology VI. Chemistry VII. Pathology Indirect Costs Subtotal Supplemental ResearchCosts Administrative TOTAL $ 50,046 36,300 17,700 7,735 27,560 27,552 21,190 59,765 $247,848 24,785 24,785 $297,418 It is the view of Panel Members that if this overall program is to yield optimum results it is important that its continuity be preserved. Work under the 1976-1977 contract will terminate during the later part of this month or during the first two weeks of November. Members of the Technical Panel urge therefore that in the event that you wish this program to continue, that your commitment be returned by October 28, 1977. Sincerely, AS I 0000146G9 Manufacturing Chemists Association Proposed Continuation of the University of Louisville Research Program on Research Techniques and Methods of Detection and Prevention of Carcinogenesis in Industrial Workers My company hereby commits a maximum of $ R.176 as its pro rata share for support of the subject program presented in A. C. Clark's letter of October 13, 1977. It is understood that my company's pro rata share is based on an estimate of 19 companies sponsoring this research program. Should the number of sponsors be greater, each pro rata share will be reduced proportionately. In making this commitment, it is understood that the Technical Panel has the authority to instruct MCA regarding expenditure of funds including the use of Supplemental Research Costs when modifying and/or extending planned protocols. Our commitment is contingent on collective subscriptions being adequate to fully fund the $297,418 program, and on Board of Directors' approval for MCA's continued administration of this program. S My company pledges support for this program. // While appreciating the opportunity presented, my company has decided not to participate in the program. Name (signed) Name (typed)_ TitleDirector-Medical Services (ICD) Company Address Allied Chemical Corporation Industrial Chemicals Division P.O. Box 1139R - Morristown, New Jersey 07960 December 8. 1977 Date 455-3546 Telephone: Area Code 2QJTumber Ext. Please return one copy no later than October 28, 1977 to: A. C. Clark Manufacturing Chemists Association 1825 Connecticut Avenue, N.W. Washington, D.C. 20009 AS I 000014670