Document Qg7gk1kobjxvk0Lwz3LZOLwOE

3M FLUOROCHEMICAL SUBMISSIONS February, 2002 - May 11, 2004 TOXICOLOGY, EPIDEMIOLOGY AND MEDICAL SURVEILLANCE Click on Study Title to View Report Multiple Chemicals PAGE 1, 2, 3 Human Sera/Medical Surveillance/Epidemiology 1. TSCA 8(e) Supplemental Notice for Sulfonate-Based and Carboxylic-Based Fluorochemicals - Docket Number 8EHQ-1180-373; 8EHQ-1180-374; 8EHQ-1180-0394; 8EHQ-0598-373. [SubmittedMarch 19, 2002] 2. Final Report, Identification of Fluorochemicals in Human Sera. I. American Red Cross Adult Blood Donors, February 25, 2002. [SubmittedMarch 13, 2002] 3. Final Report, Identification of Fluorochemicals in Human Sera. II. Elderly Participants of the Adult Changes in Thought Study, Seattle, Washington, February 25, 2002. [SubmittedMarch 13, 2002] 4. Final Report, Identification of Fluorochemicals in Human Sera. III. Pediatric Participants in a Group A Streptococci Clinical Trial Investigation, February 25, 2002. [SubmittedMarch 13, 2002] 5. Interim Report #2, Determination of Serum Half-Lives of Several Fluorochemicals, January 11, 2002. [SubmittedMarch 13, 2002] 6. Final Report, A Cross-Sectional Analysis of Serum Perfluorooctanesulfonate (PFOS) and Perfluorooctanoate (PFOA) in Relation to Clinical Chemistry, Thyroid Hormone, Hematology and Urinalysis Results from Male and Female Employee Participants of the 2000 Antwerp and Decatur Fluorochemical Medical Surveillance Program, October 11, 2001. [SubmittedMarch 13, 2002] 7. Final Report, A Longitudinal Analysis of Serum Perfluorooctanesulfonate (PFOS) and Perfluorooctanoate (PFOA) Levels in Relation to Lipid and Hepatic Clinical Chemistry Test Results from Male Employee Participants of the 1994/95, 1997 and 2000 Fluorochemical Medical Surveillance Program, October 11, 2001. [SubmittedMarch 13, 2002] 8. Comparative Analysis of Fluorochemicals in Human Serum Samples Collected by 3M and Obtained Commercially, 3M Environmental Laboratory Study Number E02-1053. [SubmittedDecember 16, 2002] 9. Analysis of Endogenous Fluorochemicals in Normal Pooled Human Serum and Plasma, 3M Environmental Laboratory Study Number E02-1039. [SubmittedDecember 16, 2002] 10. Analysis of Pooled Human Sera and Plasma and Moneky and Sera for Fluorocarbons Using Exygen Method ExM-023-07l, Exygen Research Study Number 023-082, 3M Sponsor Study. [SubmittedDecember 16, 2002] 11. Assay Validation Report, Quantitative Determination of PFOS, PFOSA, PFOSAA, N-MeFOSE-OH, Net FOSE-OH, POAA, and PFHS in Human Serum by LC/MS/MS, Northwest Bioanalytical (NWB), Study No. NWBS98-082, Report No. NWBR99-005, May 13, 1999. [Submitted January 29, 2003] 12. Assay Revalidation Report, Quantitative Determination of PFOS, PFOSA, PFOSAA, POAA, PFHS, M556 and M570 in Human Serum by LC/MS/MS, Northwest Bioanalytical (NWB), Study NO. NWBS00-040, Report No. NWBR00-108, January 24, 2001. [Submitted January 29, 2003] TOXICOLOGY, EPIDEMIOLOGY AND MEDICAL SURVEILLANCE Click on Study Title to View Report Back to Menu Multiple Chemicals PAGE 1, 2, 3 Human Sera/Medical Surveillance/Epidemiology cont. 13. Assay Revalidation Addendum Report, Quantitative Determination of PFOS, PFOSA, PFOSAA, POAA, PFHS, M556 and M570 in Human Serum by LC/MS/MS, Northwest Bioanalytical (NWB), Study No. NWBS00-040, Report No. NWBR00-122, November 20, 2001. [Submitted January 29, 2003] 14. Sample Analysis Report for Protocol EPI-0011, Quantitative Determination of PFOS and Related Compounds in Human Serum by LC/MS/MS, Northwest Bioanalytical (NWB), Study No. NWBS00-088, Report No. NWBR01-001, November 30, 2001. [Submitted January 29, 2003] 15. Sample Analysis Report for Protocol EPI-0013, Quantitative Determination of PFOS and Related Compounds in Human Serum by LC/MS/MS, Northwest Bioanalytical (NWB), Study No. NWBS00128, Report No. NWBR01-066, January 9, 2002. [Submitted January 29, 2003] 16. Sample Analysis Report for Protocol EPI-0016, Quantitative Determination of PFOS and Related Compounds in Human Serum by LC/MS/MS, Northwest Bioanalytical (NWB), Study No. NWBS00145, Report No. NWBR01-155, January 10, 2002. [Submitted January 29, 2003] 17. Final Report, NIOSH Health Hazard Evaluation for Perfluorooctanoic Acid and Perfluorooctane Sulfonate, NIOSH HETA 20010235, July 31, 2001. [Submitted July 9, 2003] 18. Final Report, Assessment of Lipid, Hepatic and Thyroid Function in Relation to an Occupational Biologic Limit Value for Perfluorooctanoic Acid, 3M Medical Department, June 9, 2003. [Submitted July 9, 2003] 19. Final Report, Descriptive Analysis of Serum Fluorochemical Concentrations from Cottage Grove Employee Participants of the 2002 Medical Surveillance Program, 3M Medical Department, June 17, 2003. [Submitted July 9, 2003] 20. Final Report, Descriptive Analysis of Serum Fluorochemical Concentrations from Decatur Employee Participants of the 2002 Medical Surveillance Program, 3M Medical Department, June 17, 2003. [Submitted July 9, 2003] 21. Final Report, Descriptive Analysis of Serum Perfluorooctanoate (PFOA) and Perfluorooctanesulfonate (PFOS) Concentrations of Antwerp Employee Participants from the 2003 Fluorochemical Medical Surveillance Program, 3M Medical Department, August 14, 2003. [SubmittedMay 11, 2004] 22. Sample Analysis Report for Protocol EPI-0012, Quantitative Determination of PFOS and Related Compounds in Human Serum by LC/MS/MS, Northwest Bioanalytical Study No. NWBS00-091, November 21, 2001. [SubmittedMay 11, 2004] 23. Sample Analysis Report for Protocol EPI-PEuro, Quantitative Determination of PFOS, PFOSA, PFOSAA, PFHS, POAA, M556 and M570 in Human Serum by LC/MS/MS, Northwest Bioanalytical Study No. NWBS99-117, December 9, 1999. [SubmittedMay 11, 2004] 24. Sample Analysis Report for Protocol EPI-Swed, Quantitative Determination of PFOS, PFOSA, PFOSAA, PFHS, POAA, M556 and M570 in Human Serum by LC/MS/MS, Northwest Bioanalytical Study No. NWBS99-116, December 9, 1999. [SubmittedMay 11, 2004] TOXICOLOGY, EPIDEMIOLOGY AND MEDICAL SURVEILLANCE Click on Study Title to View Report Back to Menu Multiple Chemicals PAGE 1, 2, 3 Pharmacokinetic Studies 1. Protein Binding of Perfluorohexane Sulfonate, Perfluorooctane Sulfonate and Perfluorooctanoate to Plasma (Human, Rat, and Monkey), and Various Human-Derived Plasma Protein Fractions, Southern Research Institute Study ID 9921.7, 3M Reference Nos. T-6295.33, T-7485.18, T-7504.4, and T-7507.4, June 3, 2003 [Submitted July 9, 2003] Toxicokinetic Study 1. Final Report, Xenochemical Receptor trans-Activation by Perfluorooctane-based Chemicals, Boston University Department of Biology, 3M Reference No. T-6295.35, September 12, 2001. [SubmittedMay 11, 2004]