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ES-3S7A E. I. d u Po n t d e Ne mo u r s & Co mp a n y INCORPORATED Wil min g t o n , De l aw a r e i9898 CENTRAL RESEARCiYd EPARTMENT ana Development HASKELL LABORATORY FOR TOXICOLOGY AND INDUSTRIAL MEDICINE cc: E. E. Swain, Jr., F&F, B2373 P. J. Graham, F&F, B2270 G. R. McClure, F&F, 293/307 B. C, McKusick, Haskell Laboratory J, G. Aftosmis, Haskell Laboratory N, D. Krlvanek, Haskell Laboratory R. N. Dion, Haskell Laboratory July 8, 1975 MEMORANDUM TO FILE FROM: C, L. DICKINSON, JR, CARCINOGEN SURVEY MEETING WITH F&F. JUNE 26, 1975 P. J. Graham, G. R. McClure, E. E. Swain, Jr, (F&F), B. C. McKusick, J. G> Aftosmis, N, D. Krivanek, and C. L. Dickinson, Jr, (Haskell) met to review the literature survey from the January 31, 1975 meeting and complete the review of F&F's raw materials. The following i$ recommended from the literature survey: A bacterial mutagen test be run on acrylamide Further literature be Sought on peroxy compounds with emphasis on follow-up of the incompletely reported work of Koten and Falk. The following materials had adequate tests so that no further work is indicated at this time: Maleic Anhydride Bakelite Epoxy Resin 4221 Melamine Formaldehyde Resin EPON 828 Bis Phenol A (keyed to EPON 828) Lead The following had no data, but consideration of use and related compounds suggests no action at this time: Desmodur N-75 Proxel CRN Triclene is under consideration elsewhere as new data has been presented and judgment at this meeting was not appropriate. BETTER THINGS FOR BETTER LIVING . . .THROUGH CHEMISTRY MEMORANDUM TO PILE -2 - July 8, 1975 From other searches that were sent as a consequence of the January 31 meeting, Swain would like a Haskell position on chromic acid and dioxane. The following is recommended from the raw materials review: A Toxiine search on diaminodiphenylsulfone be run. Literature searches already run on the following compounds or related compounds be sent to E. E. Swain: Selenium Thiuran and analogs Cadmium Carbon disulfide Tetramethyl thiourea CLD/jtd DUP050077594