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U.S. DEPARTMENT OF COMMERCE
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National Technical Information Service
-v* ^ Springfield, Va. 22161
R&S 040276
UNITED STATES DEPARTMENT F COMMERCE National Technical Information Service
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[BIBLIOGRAPHIC DATA |SIIEET
I 4, Tide and Subtitle
1. Repot. No.
Toxicity of Vinyl Chloride
(A Bibliography with Abstracts) 7.Editor:
Pernell W. Crockett
9. Performing Organization Name and Addreaa
National Technical Information Service 5285 Port Royal Road Springfield, Virginia 22161
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Mav. 1977 6.
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Same
13. Type of Report ft Period Coveted
1964 - Apr., 1977 14.
IS. Supplementary Notes
Supersedes NTIS/PS-76/0197
16, Abstracts
Research is cited on the health hazards from exposure to vinyl chloride and vinyl chloride resins. Studies are included on the epidemiology, industrial and public exposure to the compound, and its degradation and combustion products. (This updated bibliography contains 69 abstracts, 32 of which are new entries to the
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R&S 040280
111
R&S 040282
Research Program on Hazard Priority Ranking of Manufactured Chemicals (Chemicals 21-4C)
Stanford Research Inst., Menlo Park, Calif.^National Science Foundation, Uashington, D.C. Research Applied to National Needs. ( 332 500)
Final rept. on Phase 2
Brovn, s. L i Chan, F , Jougs, J I** / Liu, 0. H., mcCal3b, K. E*
0165512
Fid: 7A, 6T, 68H*, 68, 99B*, 57?* GRAI77C8
Apr 75 195p*
Project: SRI-ECU-3386
Monitor: NSF/BA/E-190B
See also PB-263 161 and PB-263 163.
Abstract: In Phase II of this two-phase effort, 80 chemicals having
the greatest potential for environmental effects were studied.
Information was collected on the extent of the exposure of the
environment to these chemicals (during manufacture and use) and on the
possible environmental effects of this exposure (chemical, physical,
and biological properties, persistence, and toxicity). The chemicals
studied in this volume are as follows: Benzene (chemical uses),
Silicone fluids, Nitrobenzene, Toluenediisocyanate (TDI), Xylenes -
mixed total,.Aniline, Dimethyl terephthalate, Trichlorotluoromethane,
p-Dichlorobenzene, Dithiobis (benzothiazole), o-Dichlocobenzene,
Tetrabromoethane, Methylene (bis)-2-chloroaniline, Polyhalogenated*
biphenyls (Aroclor 1254) , Tricresyl phosphate. Fluorescent brightening
agents. (no.*
28), Polyvinyl chloride. Methylene chloride,
Dichloropropene, Dichloropropane mixture, and Ethyl chloride.
(Portions of-this document are not fully legible.)
Descriptors: ^Hazardous materials, ^Chemical industry, ^Environmental impacts, *0rganic compounds. Manufacturing, Utilization, Chemical properties. Physical properties. Toxicology, Bioassay, Public health. Tables (Data), Releasing, Air pollution. Water pollution. Chemical analysis. Soil analysis. Benzene, Silicones, Nitroher.^.i.es, xylenes. Aniline, Biphenyl, Polyvinyl chloride, chloroethanes. Fluorescence, Optical brighteners. Industrial wastes. Halogen organic compounds
Identifiers: Hethane/trichloro-fluoro, Bonzene/dichloro, Et'nane/tetr a-
bromc, Aroclor 1254, Propane/dichloro, Methylene/chloro, isocyanic
acid/(Hethylphenylene-ester),
Terephthalic acid/(Dimethyl-ester) ,
Benzothiazole thiols, Aniline/H-N-bis (Chloromethyl), Phosphate/tricre-
syl, KTISMSFHA, HTISSRI
PB-263 162/0ST NTIS Prices; PC A09/MP A01
1
R&S 040284
Toxicology of Plastics Having Contact with Blood. Report ot Program progress
Travenol Labs., Inc., Morton Grove, 111.*Nat ional Heart, Lung, and Blood Inst., Bethesda, Md.
Annual rept.
Josephson, A. M.
D1503C4
Fid: 6T, 6L, 571, 95C GRAI7707
May 75 22p
Contract: N01-HB-2-2990, PHS-72-2990
Monitor: NIH-NO1-HB-2-2990
Abstract: Di-2-ethylhexyl phthalate (DEHP) was extracted from polyvinyl chloride (PVC). This material was diluted in sterile rat plasma and used to inject, IV, groups or rats with a 3.7 mg/kg/injection, which is eguivalent to the DEHP dose that a patient would receive from a total exchange transfusion of blood. Growth r^tes, gross reactions following injections, hematology and serum chemistry parameters, gross organ pathology, absolute and relative organ weights, histopathology, and residual DEHP levels in plasma and tissues were similar for all groups, including plasma control groups.
Ho toxicology significant changes were observed.
Descriptors: *Toxicology, *Plasticizers, *Polyvinyl chloride. Toxicity , Plastics, Medical supplies. Medical equipment. Blood, Bioassay, Bats
, Laboratory animals
Identifiers: *Phthalic acid/bis(Bthylhexyl-ester), *Blood compatible mat rials, Bioaaterials, HTISNIHHLI
PB-262 260/3ST NTIS Prices: PC A02/HF A01
3
Problems of Occupational Hygiene and the state of Health of workers Employed in Manufacturing Latex Polyvinyl Chloride (Voprcsy Giyxer.y Truda i Sostoyanie Zdorovya Kabochikh, Zanyatykh na Proizvedst v--
Lateksnoyo Nolivinilkhlorida)
Environmental Protection Agency, Research Triangle Park, n.c.
Translation Services Section.
Filatova, 7. S., Gronsberg, E. Sh., Smirnova, N. A., Stulova, E. A.,
Oreshkevich, I. v.
D1345G3
Fid: 6J, 6T d7706
1965 lOp
Rept No: EPA-TR-76-366
Monitor: 18 Trans, of Gigiena Truda i Professionalnye Zabolevaniya (USSR) v9 n8
p9-14 1965.
Abstract: Pollution of the air with vinyl chloride and resin dust is p ssible during the manufacture of latex polyvinyl chloride. Such pollution is caused by disruption of the seal of equipment and by carrying out certain operations manually. During the study of the state of health of the workers, some of them were found to have changes characteristic for the initial forms of chronic vinyl chloride intoxication: slightly pronounced disorders of the vegetative-vascular regulation, symptoms of vegetative polyneuritis and thermoregulatory
disorders. An improvement in the conditions of labor of workers employed in manufacturing latex polyvinyl chloride can be attained by means of sealing the equipment, improving technological operations and
improving the function of ventilation;
Descriptors: ^Polyvinyl chloride, ^industrial hygiene, *Toxicity, Hazardous materials, Health status. Toxic diseases. Manufacturing, Industrial medicine. Translations, USSR, Toxicology, Industrial atmospheres. Recommendations, Pathology
Identifiers: Occupational safety and health. Toxic substances, *Air pollution effects {Humans), HTISEPAISD
PB-261 764-T/ST NTIS Prices; PC A02/HF A01
33 &> CO -ofe
CO O)
5
Current Awareness Service for Toxic Substances (CATS). Cumulative Report number 2. Part II
Little (Arthur D.), Inc., Cambridge, Mass,^Environmental Protection Agency, Washington, D.C. Office of Toxic Substances. (208 850)
Annual rept.
D1241B2
Fid: 13B, 6T, 68*, 57Y* GRAI7705
Nov 76 364p*
Hept No: ADL-C-77355-Pt-2
Contract: EPA-68-01-2694
Monitor: EPA/560/7-76/002a
See also report dated Dec 75, PB-250 075 and Part 1, PB-260 360.
Abstract: The scanning topics included in this two part series are the
chemicals and subject areas as follows: Acetonitrile, acrylonitrile,
arsenic, aryl phosphates (phenyl, cresyl, mixed phenyl-cresyl),
asbestos, benzidine, and salts (hydrochloride, sulfate), boron,
broninated biphenyls, dichlorobenzidine, dioxane, ethyleneimine, flame
retardants,
fluorocarbons,
haloethers,
hexachlorobenzene,
hexachlorobutadiene, hydrazine, derivatives, and salts (sym and unsyir
dimethyl, monomethyl) , isocyanates (organic), liquefaction and
gasification of coal, methylenebis (chloroaniline), model ecosystems
(environmental fate testing, microecosystems), naphthylamines (alpha,
beta,
N-phenyl derivatives) , nitrilotriacetic acid, optical
brighteners (fluorescent whitening agents, fluorescent dyes),
perchloroethylene,
phthalates
(dioctyl,
di-2-ethylhexyl),
polyurethanes, propiolactone, trichloroethylene, shale oil extraction
and refining, vinyl chloride, vinylidene chloride, ethylene dibromide,
and nitrosamines*
Descriptors: *Toxicity, *Cheaical elements, *Pollution, vinylidane
chloride resins. Acetonitrile, Acrylonitriles, Arsenic, Phosphates,
Cresols, Phenols, Asbestos, Nitrosamines, Lactones, Benzidine, Boron,
Biphenyl,
Dioxanes,
Aziridines,
Fire resistant materials,
Fluorohydrocarbcns, Ethers,
Halogenorganic
compou.i ,
Coal
gasification. Hydrazines, Isocyanates, Ecosystems, Amines, optical
brighteners, Phthalates, polyurethane resins, Naphthalenes, Shale oil.
Extraction, Refining, Vinyl chloride
Identifiers: Bipheny1/bromo, Benzidine/dichloro, Coal liquefaction, Benzene/hexachloro, Butadiene/hexachloro, Aniline/N-N-bis (Chlorometh y1), Naphthylamines, Acetric acid/nitrilo-tri, Ethylene/chloro, Ethylene/trichloro, Ethylene/dibromo, NTISEPAOTS
PB-260 361/1ST NTIS Prices: PC A16/MF A01
R&S 040288
R&S 040290
The So-Called Vinyl Vinylchlorid-Krankheit)
Chloride
Disease
(Uc-ber die Sogenannte
Environmental Protection Agency, Research Triangle Park, N.c.
Translation Services Section.
duehe, S., Lange, C. -E., Stein, G,, Veltman, G.
D0345B1
Fid: 6J, 6T, 57U, 57Y, 68G GRAI7702
1975 15p
Rept Ro: EPA-TR-75-6
Monitor: 18
Trans, of Deutsche Medizinische Wochenschrift (West Germany) v98
p2034-2037 n.d.
Abstract: Since the first reports on impairments of health of workers in the vinyl chloride (VC) industry appeared in 1958, and of workers in the polyvinyl chloride (PVC) industry in 1963, attention has been repeatedly directed at this branch of the chemical industry by further reports. A syndrome was observed which was similar in its skin and bone changes to scleroderma, while its etiology and pathogenesis r mained unresolved. Its principal symptom was the Raynaud syndrom? -- nodose or surface hard skin changes and band-shaped osteolyses of the finger end-phalanges. The first observations of this disease pattern was reported in Germany in 1972. The authors have recently made an exhaustive report on the results obtained through the end of 1972, which reveal new aspects in the assessment of the disease. The most important features are summarized.
D scriptors: Occupational ' diseases, *Vinyl chloride, Industrial medicine, Integumentary diseases, Toxicology, Dermatology, Chemical industry. Skin diseases, - Signs and symptoms. Gases, Pathology, Pathophysiology, Histology,' Rest Germany, Translations
Identifiers: Air pollution effects (Humans), Environmental health. Occupational safety and health, NTISEPAISD
PB-256 830-T/ST NTIS Prices: PC A02/MF A01
9
Evaluation of Vinyl Chloride Emissions in the Long Beach Area, California
National C7694A3 Hay 74 Bept Ho: Honitor:
Field Investigations Fid: 13B, 68A, 68D
47p EPA/330/2-74/002 18
Center, Denver, GRAI7625
Colo.
Abstract: A survey of vinyl chloride emissions from the American
Chemical Corporation and B.F. Goodrich Chemical Company showed that vinyl chloride monomer was leaving the plants via water, sludge, and
air as well as in the final product, polyvinyl chloride. It is
estimated that about 2.3 kg (5 lb)/day of pvc leave the B.F. Goodrich
plant, and 10 kg (22 lb)/day leave the American Chemical plant in the wastewater effluents. Smaller quantities were found in the sludge. The report presents a plant evaluation and a sampling program.
Descriptors: *Pollution, *vinyl chloride, *polyvinyl chlorida. Surveys , Water pollution. Sludge, Air pollution, Infrared spectrometers. Evaluation, Industrial plants. Toxicity, Environmental impacts. Safety
, Public health. Assessments, Sampling, California
Identifiers: Long Beach(California), NTISEPAO
PB-257 642/9ST NTIS Prices: PC$4.00/HF$3.00
00 & CO
4 0292
11
Sampling and Analysis of Selected Toxic Substances. Task III. Vin y 1 Chloride, Secondary Sources
Hidwest Research Inst., Kansas City, o.*Environmental Protection Agency, Washington, D.c. Office of Toxic Substances. {230 350)
Final rept. 1 Nov-31 Dec 75
Going, John E.
C6824L2
Fid: 06T, 06F, 13B, 57Y, 57H, 68A,
Apr 76 30p
Contract: EPA-68-01-26U6
fionitor: EPA/560/6-76/002
S e also report dated Sep 75, PB-246 213.
68G,
99A
GRAI7616
Abstract: A sampling and analysis program was conducted to determine whether and to what extent vinyl chloride was present in ambient air due to the presence of polyvinyl chloride products, sampling environments were chosen to represent real life, but nonwork situations where a significant exposure to polyvinyl chloride products might occur. A sampling and analysis protocol was developed with a r covery efficiency of greater than 9016 and a detection limit of Hi ppb (v/v). The two general categories of environments sampled were
vehicles and commercial products. The interior ambient air was sampled from new and used domestic automobiles, foreign automobiles and
domestic mobile homes. No evidence of vinyl chloride was found. The f 1lowing commercial vinyl products, when sampled in their normal environment, did not produce a measurable quantity of vinyl chloride in the ambient air: vinyl wall covering; vinyl swimming pool liners;
and vinyl nursery products. A room being painted with a heavily pigmented red paint was found to contain a very low level of vinyl
chloride.
Descriptors: *Toxicology, *Carcinogens, *Vinyl chloride. Air pollution , Automotive industry. Sampling, Exhaust emissions. Combustion products. Public health. Vehicles, Paints, Fabrics, Gas chromatography , Gas analysis. Charcoal, Adsorbents, Sites, Sources
Identifiers: *Air pollution sampling. Cancer, Environmei tal heilth. Secondary sources, NTISEPAOTS
PB-252 966/7ST NTIS Prices: PCS4. 00/MF$2.25
20
Bo
CO
13
Toxicology of Plastic Devices Having Contact, with blood
Utah Univ., Salt Lake City. Dept. of Applied Pharmaceutical Sciences.*National Heart and Lung Inst., Bethesda, Hd,
Final rept. 24 Aug 72-23 Aug 75 Petersen, Robert V., Lyman, Donald J., Roll, David 3.,
A. C6282K3
Fid: 06T, 06L, 57Y, 95A, 95C GRAI7610
23 Ang 75 248p
Contract: PHS-73-2908
Monitor: NIH/NHLI-72-6-F
See also report dated 1 Hay 75, pb-244 753.
Svinyard,
Ewart
Abstract: The project was primarily concerned with toxicological valuation of polyvinyl chloride and, more specifically, the commonly
used plasticizer, di(2-ethylhexyl) phthalate (DEHP). Evaluations are primarily concerned with long range, subtle toxicity potential,
although many basic acute and subacute studies were also conducted. Th project is divided into twelve tasks including an organizational phase, plastic composition studies, acute toxicity studies, tissue culture studies, subacute toxicity studies, metabolite identification, t ratogenic studies, neurologic studies, larger animal studies, analyses of human blood exposed to plastics during hospital pr ced-ures, and possible statistical analysis of human patients
following extensive exposure of blood to plastics,
D sciri'ptors: polyvinyl
chloride,
*Plastics, *plasticizers,
Toxicology, Patients, . Tissue culture. Bioassay, Laboratory animals.
Pathology, Rats, Heart, Phthalates, Body fluids, Neurology, nice.
Reproduction (Biology)-, Medical supplies. Mechanical organs. Humans,
Blood.
Identifiers: Blood compatible materials, Eiomatenals, Phthalic acid/bis(ethylhexyl-ester), Metabolites, KTISNIHHLT
PB-250 102/1 ST HTIS Prices: PC$8.00/MF$2.25
R&S 040296
15
R&S 040298
Scientific and Technical Assessment Report on Vinyl Chloride end Polyvinyl Chloride
Environmental Protection Agency, Research Triangle Park, N.c.
Pinal rept.
C6105G3
Fid: 06T, 06J,
Dec 75 125p*
Bept No: EPA/600/6-75/004
Monitor: 18
See also PB-246 820.
13B,
57Y*,
570,
68G*,
68A,
68D
GRAI7608
Abstract; Vinyl chloride (VC) is a chemical of widespread industrial and commercial use. Occupational experience and experimental evidence strongly indicate that it is a carcinogen. Additionally, there is experimental evidence that indicates that it may be a teratogen and mutagen. An increased incidence of liver angiosarcoma, excessive liver damage, and acroosteolysis has been reported among VC workers, and the frequency and severity of the liver pathology is related to the length
of exposure* The principal route of exposure is thought to be air
inhalation. Sources of increased importance for the general population include food and water. Tumors at multiple and diverse sites have been observed in all species of experimental animals tested for
carcinogenicity by inhalation and ingestion of vc. in addition to the
h alth effects of VC, this document also considers the sources, distribution, and control technology.
D scriptors: *Polyvinyl chloride, * Vinyl - chloride, ""Toxicology, Industrial medicine. Air pollution. Public health. Liver, Malignant neoplasms. Carcinogens, Mutagens, water pollution. Food chains. Humans , Laboratory animals. Experimental data. Chemical compounds. Chemical
industry
Identifiers: *Air pollution effects(Humans), *Environmental health. Teratogens, Air pollution control. Water pollution ef facts (Hu mars) ,
NTISEPAOED
PB-249 461/5ST NTIS Prices: PC$5.50/KFS2.25
R&S 040300
Health Hazard Evaluation/Toxicity Determination Report H.h.e. 75-81-252, Artex Manufacturing Company, Inc., overland park, Kar.cir
National Inst, for Occupational Safety and Health, Cincinnati, Ohio. (390 766)
Final rept, May-Jun 75
Herrin, Raymond L.
C6104L2
Fid: 06J, 06T, 570, 94D,
Dec 75 lip
Hept No: NI0SH-TR-HHE-75-81-252
Monitor: 18
see also PB-249 31.
68G
GRAI7608
Abstract: A health hazard evaluation was conducted by NIOSH at a plant involved in the silk screen dyeing of decals onto various textile garments. It was determined that employees in the two main production areas were not exposed to toxic concentrations of vinyl chloride and organic solvents, including 1,1,1-trichloroethane, toluene, xylene, and petroleum naphtha. It was further determined that the clean room operator was exposed to potentially toxic concentrations of organic solvents from cleaning silk screens with an organic solvent containing
primarily naphtha.
Descriptors: *Hazardons materials, ^Industrial medicine, *vmyl chloride, *Toluene, *Xylenes, Toxicity, Criteria, Inspection, Standards, Recommendations, Industrial hygiene. Industrial atmospheres , Fumes, Organic solvents. Exposure, Chloroform, Naphthas, Textile
industry
Identifiers: *Occupational Safety and -Health Act of 1970, *Toxic hazards, NTISHEWOSH
PB-249 432/6ST NTIS Prices: PC$3.5Q/MFS2.25
\
\ %\ 19
Baiird Evaluation/l'oxicity Determination Report H.H.E. --j j-1? 3-2 44, Borden Chemical Company, Leominister, Ha ssach usetti;
National Inst. for occupational Safety and Health, Cincinnati, Ohio. {390 766)
Final rept.
Polakoff, Phillip Lee
C6104J2
Fid: 06J, 06T, 57U, 94D,
Dec 75 14p
Bept Bo: HIOSH-TR-HHE-73-173-244
Monitor: 18
68G
GRAI7608
Abstract: HIOSH investigated an alleged health hazard from trypsin, a prot olytic enzyme, and Nekal B-78, a surfactant, in a plant manufacturing polyvinyl chloride resins* Employees were administered non-directed medical questionnaires, skin tests and pulmonary function tests. It was determined that a number of employees had developed allergic sensitization to trypsin, resulting in respiratory impairment. Some employees who have not been sensitized have still developed mild upper respiratory tract irritation. It was also determined that several employees who handled the surfactant Nexal B-78 had periodically experienced upper airway irritation, gagging, and shortness of breath. This problem was judged to be the result.of poor work practices and no serious health consequences from this
exposure were observed or anticipated.
R&S 040302
escriptors: ^Hazardous materials, ^Industrial medicine, Polyvinyl chloride, Trypsin, *Surfactants. Toxicity, criteria. Inspection, Standards, Recommendations, Industrial hygiene. Industrial atmospheres , Exposure, Respiratory system. Chemical industry. Allergic diseases
Identifiers: *Occupational Safety and Health Act of 1970, Toxic hazards, NTISHEHOSH
PS-249 424/3ST KTIS Prices: PCS 3.50/BF $ 2,2 5
Health
Hazard Evaluation/Voxi cii:y
ciei p.inatioi-,
711-61-232, Gates Rubber Company* Denver, Colorado
Report 11, :i. ,
National Inst. for Occupational Safety and Health, Cincinnati, Ohio. (390 766}
Final rept. Jun 74-Hay 75
Gunter, Bobby j., Lucas, James B.
C6104G2
Fid; 06J, 06T, 57U, 94D,
Nov 75 16p
Rept No: KIOSH-TR-HHE-74-61-232
Monitor; 18
See also PB-249 413.
68G
GRAI7608
Abstract: A plant manufacturing extruded hose, principally from the extrusion of polyvinyl chloride, was investigated by niosh to evaluate employee exposures to cyclohexanone, TDI, trichloroethylene, Estane thermoplastic polyurethane, methylene chloride, Nigrosine, Di-2-ethyl hexyl phthalate (DOP oil), dust, and vinyl chloride. It was determined that a potential health hazard may exist from exposure to cyclohexanone, and that several cases of primary irritant dermatitis
had occurred following repeated exposure to solvents. Although only
one of 38 vinyl chloride samples was found to exceed the Federal Standard action level, it was recommended that airborne concentrations be reduced to ' levels not detected -by the recommended analytical techniques.
R&S 040304
Descriptors: ^Hazardous materials, `^Industrial medicine,, *Vinyl chi ride resins, *Cyclohexanones, . ^Solvents, Organic solvents. Polyvinyl chloride. Isocyanates, Polyurethane resins. Plastics, Toxicity, Criteria, Inspection, Standards, Recommendations, Industrial hygiene. Industrial atmospheres, Chloromethanes, Hoses, Manufacturing, Dermatitis, Carcinogens
Identifiers: *0ccu pat ional Safety ar.d Health Act of 197P, v"Voxic hazards. Air sampling, NTISHEWOSH
PB-249 412/8ST NTIS Prices; PC43.50/NF$2.25
Health Hazard Evaluation/Toricity Determination Report II.H.i:. 75-94-219, Proto Production Plastics, Inc., Boulder, Colorado
National Inst, for occupational Safety and Health, Cincinnati, Ohio. (390 766)
Final rept. Babe, Baymond L.
C6104D1
Fid: 06J, 06T, 57U, 94D,
Sep 75 6p Rept No: NIOSH-TR-HHE-75-94-219
Konitor: 18
See also PB-249 400.
68G
GRAI7608
Abstract: A plant manufacturing,polyvinyl chloride telephone switchbox covers by means of an injection molding process was investigated by NIOSH to evaluate exposure of employees to vinyl chloride. Air samples v re obtained for vinyl chloride analysis and there were no detectable amounts of vinyl chloride found. Non-directed medical questionnaires were also administered and on the basis of medical and environmental data, it was determined that a health hazard did not exist at the time
of this evaluation.
Descriptors: *Hazardous materials, *Inaustrial medicine, ^Polyvinyl chloride. Vinyl chloride resins. Plastics industry. Carcinogens, Gases , Exposure, Toxicity, Criteria, Inspection, Standards, Recommendations , Industrial hygiene. Industrial atmospheres
Identifiers: *Occupational Safety and Health Act of 1970, *Toxic hazards. Air sampling, NTISHEWOSH
FB-249 399/7ST NTIS Prices: PC$3.50/ttF$2.25
37 Co
9 e o t.0
25
health Hazard Evaluation/Toxicity Determination He port il.ii.i:. 74-59-217, Goodyear Tire and Rubber Company, St. Karys, Ohio
national Inst. for Occupational Safety and Health, Cincinnati, Ohio. (390 766)
Pinal rept. Jul 74-Har 75
Vandervort, Robert
C6104C3
Fid; 06J, 06T, 570, 94D,
Aug 75 6p Rept No:. NIOSH-TR-HHE-74-59-217
Honitor: 19
See also PB-249 398,
68G
GRAI76G8
Abstract: NIOSH evaluated employee exposures to vinyl chloride monomer in the airing and fils casting processes during the manufacture of cl ar plastic films by the solvent casting aethod. Air samples were obtained and no detectable levels of vinyl chloride were found. It was determined that a health hazard did not exist at the time of this
evaluation.
Descriptors: *Hazardous materials, *Iadustrial medicine, *Vmyl chloride, *Polyviayl chloride. Plastics industry. Carcinogens, Toxicity, Criteria, Inspection, Standards, Recommendations, Industrial
hygiene. Industrial atmospheres
Identifiers: ^Occupational Safety and Health Act of 1970, *Toxic hazards. Air sampling, NTISHEHOSH
PB-249 397/1 ST HTIS Prices: PC$3.50/HF$2.25
R&S 040308
27
A
.e a 11 h
Hazard Evaluation/Toxicity
Deter m i n a t i o n ; .iport.
75-20-209 , Richdel Corporation, Carson City, Nevada
li. li.
National Inst. for Occupational Safety and Health, Cincinnati, Ohio. (390 766)
Final rept. Mar-Apr 75
Ottawa, Melvin T.
C6104A3
Fid: 06J, 06T, 57U, 94D,
Jul 75 8p
Rapt No: NIOSH--TB--HHE-75-20-209
Monitor: 18
Sea also PB-249 3 90.
68G
GKAI7608
Abstract: A regrinding operation in a plant manufacturing molded plastic valves was studied by NIOSH. Based upon environmental air sampling measurements, analysis of work practices, and on available information regarding the toxicity of vinyl chloride, it was
determined that a potential health hazard does exist.
Descriptors: "Hazardous materials, ""Industrial medicine, "Vinyl chloride, ""Carcinogens, Toxicity, Criteria, Inspection, Standards, Recommendations, Industrial hygiene. Industrial atmospheres. Plastics,
Valves, .Holdings
Identifiers: *Occupational Safety and Health Act of 1970, "Toxic
hazards,- Air sampling, MTISHEWOSH
..
PB-249 389/8ST NTIS Prices: PC$3. 50/MF$2.25
37 So CO
ft&S 040312
Ik- o 'i v h h av, c. i. d E v 1 u ai: i r. n/T c)' i c 11 y Enter w '.nation 74-- i3 rij, p lie Industries, Inc.,- CifeJon , No-.' Jersey
Feport
ii. !:.
National last, for Occupational Safety and Health, Cincinnati, Ohio. (390 766)
Final rept. Gilles, Dawn
C6103I3
Fid: 06J, 06T, 57U, 94D,
May 75 6p
Eept No: NIQSH-TB-HHE-74-134-193
Monitor: 18
See also PB-249 374.
68G
GRAI7608
Abstract: NIOSH conducted a health hazard evaluation at a plant which manufactured handles from PTC resins. On the basis of environmental sampling conducted at the molding and extrusion processes, it was determined that a health hazard from exposure tc vinyl chloride
monomer did not exist at the time of this evaluation.
D scriptors: ^Hazardous materials, ^Industrial medicine, *Vinyl chloride, ^Polyvinyl chloride, ^Carcinogens, Toxicity, criteria. Inspection, Standards, Becoumendations. Industrial hygiene. Industrial
atmospheres. Extrusion, Exposure, Moldings, Polymers
Identifiers: *occupational safety and Health Act of 1970,*Tcxic hazards. Air sampling, NTISHENOSH
PB-249 373/2ST NTIS Prices: PC$3,50/MFJ2.25
31
"pi deaiio logy Studies. Task III. vinyl ChIo:id
American Public Health Association, Washington, O.c*
irci.uenta 1
Protection Agency, Washington, D.C. Office of. Toric Substances.
Final rept. AUTHOR; Landau, Emanuel, Brinkman, Charles P.,'
C5875H1
FLD: 06J, 570*, 68G* USGRDR7605
Nov 75 106p*
CONTRACT: EPA-68-01-2U90
MONITOR: EPA/560/6-75/00 2
Kanos,
Nicholas
f,.
ABSTRACT: Using data from the 1970 Census of Population estimates of the number of people living within a 5 mile radius of industrial plants producing vinyl chloride and vinyl chloride resins was prepared* Findings are reported* The sex, and age characteristics are provided,
DESCRIPTORS: *Epidemiology, *Vinyl chloride, *Industrial medicine, Public health. Vinyl chloride resins. Industrial plants. Exposure, Populations, Demography, Tables (Data), Environments
IDENTIFIERS: NTISEPAOTS PB-248 4.26/9ST NTIS Prices: PC$5.50/MF$2. 25
30
CO
to-ufe 4^
33
lt.h Hazard Evaluation/Toxici ty Dotermir ti or. Ho port tecto Wrap Company, Denver, Colorado
National Inst. for Occupational Safety and Health, Cincinnati, Ohio. (390 766)
Final rept. AUTHOR: Butler, George J.
C5793H4
FLD: C6J, 06T, 57U, 94D,
Apr 75 7p
BEPT NO: NIOSH-TR-HHE-74-149-180
MONITOR: 18
68G
USGRDR7604
ABSTRACT: The environmental survey of a plant manufacturing a polyvinyl chloride backed material by NIOSH investigators revealed potentially hazardous levels of vinyl chloride gas. It was recommended that airborne concentrations of vinyl chloride be reduced to
non-detectable levels and that respirators be worn by exposed employees until control measures are effective.
DESCRIPTORS: ^Hazardous materials, *Industrial medicine, *Vinyl chloride, *Polyvinyl chloride. Toxicity, Criteria, Inspection, Standards, Recommendations, Industrial hygiene. Industrial atmospheres , Exposure, Evaluation, Plastics industry. Respirators, Gases, Surveys
IDENTIFIERS: *0ccupational Safety and Health Act of 1970, *Toxic hazards. Air sampling, NTISHBWOSH
ft- 246 496/4ST NTIS Prices: PC$350/NFS2.25
R&S 040316
ea It h Hazard Evaluation/Toxicity Determination Report 74-89-iay, New i: k T ie phone and T;legraph Company, Re.: V or:. !! V
National Inst. for Occupational safety and Health, Cincinnati, Ohio. (390 766)
Final rept.
AUTHOR: Straub, Wesley E.
C5793H1
FLD: 06J, 06T, 57U, 94D,
Apr 75 7p
EEPT NO: NIOSH-TR--HHE--74-69-189
HONITOB: 18
68G
USGRDE7604
ABSTBACT: NIOSH conducted an environmental survey to determine employee exposure to vinyl chloride, styrene, benzene, and hydrogen chloride during the application of heat shrinkable tape to telephone cables. It was determined that air concentration levels were below detectable levels for all substances tested and therefore were judged to be not toxic under the conditions noted during this evaluation.
DESCRIPTORS: Hazardous materials, Industrial medicine, *Styrene, Benzene# Hydrogen chloride# Vinyl chloride# Toxicity# Criteria, Inspection, Standards, Recommendations, Industrial hygiene. Industrial atmospheres. Evaluation, Exposure, Coatings, Polyvinyl chloride, Thresholds(Perception), Toxic tolerances
IDENTIFIERS: Occupational Safety and Health Ac t of 1970, Toxic izards# Air sampling. Maximum permissible exposure. NTISHEWOSH
PB-246 493/1ST NTIS Prices.: PCS3.50/MFS2.25
\
37 flo CO
040318
37
1th Hazard Evaluation/Toxicity Determination Report 74-71-142 !l.eo homy Division, Anaheim* California
National Inst* for Occupational Safety and Health, Cincinnati, Ohio. (390 766)
Final rept. AUTHOR: Okawa, Melvin T.
C5793G1
FLD: 06J, 06T, 57U, 94D,
Sep 74 5p REPT NO: NIOSH-TR-HHE-74-71-142
MONITOR: 18
68G
USGRDR7604
ABSTRACT: An operation in which polyvinyl chloride was being used to manufacture the separators used in automobile batteries was studied by
NIOSH investigators. It was determined that vinyl chloride vapors were not toxic at the concentrations measured during normal operating conditions. This determination was based upon the environmental levels
of chloride, the conditions of use of polyvinyl chloride, and current
information available on the toxicity of vinyl chloride.
DESCRIPTORS: ^Hazardous materials, *lndustrial medicine, *Vinyl chloride, *Battery separators. Toxicity, Criteria, Inspection, Standards, Recommendations, Industrial hygiene. Industrial atmospheres , Vapors, Exposure, Evaluation, Electric batteries
IDENTIFIERS: ^occupational Safety and Health Act Of 1970, * Toxic tzards. Battery industry. Air sampling, NTISHEWOSH
PB-246 489/9ST NTIS Prices: PCJ3.50/MFS2.25
R&S 040320
39
R&S 040322
Toxicology of Plastic Devices Having Contact with Blood
Children's Hospital Medical Center, Boston, Hass.*Nationa1 heart and
Lung Inst,, Bethesda, fid.
(082 790)
Comprehensive rept. Sep 72-Sep 75
AUTHOR: Kevy, Sherwin V., Button, Lawrence N.,
C5751F1
FLD: 06T, 131, 06L, 57Y*, 710, 95C
Oct 75 112p*
CONTRACT: PHS-72-2968
MONITOR: NIH/NHLI-72-2969-CR
See also PB-244 7 53.
Jacobson, May USGfiDR7603
S.
ABSTRACT: The objectives of this research were twofold: (1) the utilization of an animal model to evaluate the functional effect of Di-2-ethylhexylphthalate (DEHP) accumulation, and (2) the development of an in vitro testing procedure that could be correlated with the animal studies. The rate of extraction of DEHP from polyvinyl chloride (PVC) is dependent upon both the temperature during storage and the lipid content of the medium. DEHP so obtained is in true solution, with particle sizes less than 0.22 micron. Tissue culture studies
demonstrate that solubilized DEHP in varying concentrations inhibits
the growth and ultimately kills human diploid fibroblasts. PVC and siliconized glass transfused rhesus had abnormalities in liver histopathology and liver functions for up to 14 months following
cessation of transfusions. DEHP or silicon persisted in the tissues for up to 14 months post-transfusion. Both the control rhesus and those transfused with platelets processed in polyethylene containers
were normal.
DESCRIPTORS; Plastics, *Toxicology, *Polyvinyl chloride. Blood, In vitro analysis. In vivo analysis. Tissue culture. Body fluids. Blood plasma. Blood serum. Blood cells, plasticizers. Polymers, Blood transfusion. Liver, Spleen, Tissues (Biology) , Histology, Pathology,
Monkeys, Experimental data. Accumulation
i'Dh HTIFI BBS :
t e r i Is , *fllood coitpa t ii. Ic- Materials, Animaj models
t *Phthalic acid/bis(ethylhexyl-ester), Histoparhology, Bioacc.umn 1 at x-
on, NTISNIHHLI
P13"247 1 68/8ST HTIS Prices: PC$5.50/MFS2.25
M4 1j
Registry of Toxic Effects of Chemical Substances, 1975 Edition
National Inst, for Occupational Safety and itejlv li Hcclviile,
AUTHOR: Christensen, K. E., Luginbyhl, T. T., Carroll, u
C5673A3
FLD: 06T, 06J, 57V*, 57U, 68G* USGR DR7 6 0 2
Jun 75 1399p*
REPT NO: NIOSH-TSL-75
CONTRACT: PHS-CDC-99-74-92
MONITOR: 18
.-M.
ABSTRACT: The 1975 Edition of the Registry of Toxic Effects of Chemical Substances, formerly known as the NIOSH Toxic Substances List, is the fifth Edition prepared in compliance with the requirements of the Occupational Safety and Health Act of 1970 (PL-91-596). This Registry contains toxicity information on
approximately 17,000 unique chemical substances along with about 48,000 synonyms. Information is given on route of entry, toxic dose and toxic effects including an indication of existing evidence of the substance may be carcinogen, mutagen, teratogen, etc.
DESCRIPTORS: *Toxicity, *Chemical compounds, ^Hazardous materials. Indexes(Documentation), Public health. Dosage, Industrial medicine. Standards, chemical properties. Exposure, Asbestos, Pesticides, Carcinogens, Vinyl chloride. Mutagens, Aquatic animals. Toxicology
ipdeernmtiisfsieibrles** eOSpccousp^ea,tionTael raStoagfeetnyI, anOdccuHpeaatltihonaAl ct saofef ty19a7n0d, Mheaxaimltuhm, NTISREWOSH
PB-246 557/3ST NTIS prices: PC$41.75/MP$2.25
R&S 040324
43
Toxicology of plastic Devices Having Contact uith Blood
tah Univ.,, Salt Lake City. Dept.. oi Applied Phar Kaceuu cal Sciences. National Heart and Lung Inst., Bechesda, Hd.
Annual rept. 1 Hay 74-30 Apr 75
AUTHOR: Petersen, Robert V., Lyman, Donald J., Roll,
Swinyard, Ewart A.
C5332D3
FLD: 06T, 06L, 57Y*, 95A, 95C USGRDR75 23
1 May 75 116p
CONTRACT: PHS-73-2908
MONITOR: NIH/NHLI-72-6
See also PB-233 701.
David B.,
ABSTRACT: The project is concerned with toxicological evaluation of polyvinyl chloride (PVC) and, more specifically, the commonly used plasticizer, di-(2-ethylhexyl) phthalate (DEHP). selected findings
indicate that (1) the acute and subacute LD50 of a metabolite of DEHP
(mono-(2-ethylhexyl)
phthalate)
given
intravenously
or
intraperitoneally in mice or rats is highly toxic and irritant. (2)
Analysis of particle size distribution of DEHP dispersed in fetal calf
serum by sonication indicates that the vast majority of particles are
less than 2 microns diameter. (3) DEHP appears to have some effect on
chromosomes in human leukocytes and human fetal lung cells in tissue culture. (4) DEHP prolongs hexobarbital sleep, phthalate-contaminated
sheets caused greater adhesion and aggregation of platelets than
methanol-cleansed PVC when exposed to sheep blood in ex-vivo
experiments,
I
"DESCRIPTORS:
Polyvinyl
chloride,
Plastics, Plasticizers,
Toxicology, Lethal dosage. Pathology, Body fluids. Blood, Laboratory
a'nimals. Tissue culture, Bioass'ay, Humans, phthalates. Medical
supplies. Mechanical organs
IDENTIFIERS: Blood compatible materials. Biomaterials, Phthalic acid/bis (ethylliexyl-ester) , NTIS NIlih'LI
V?Ii" 24 4 7 5 3/0 ST NT 1S Prices: PCS 5.2 5/tt F $2.2 5
R&S 040326
I
< ;1 p
i
45
blent Air Measurements of Vinyl Chloride in the Niagara Falls Area ational Environmental Research Center, Research Triangle Parr, N,c, Chemistry and Physics Lab.
Environmental monitoring series
AUTHOR: Gay, Bruce V, Jr, Noonan, Richard C.
C5175A3
FLD: 13B, 07A, 06F, 68A, 99B, 57U
Hay 75 19p
REPT NO: EPA/650/4-75/020
PROJECT: EPA-ROAP-21 ARC
MONITOR: 18
USGRDR7521
ABSTRACT: A 6-day survey was conducted in the Niagara Falls area to determine the concentration of vinyl chloride in the atmosphere. Samples vere obtained in a residential area adjacent to the chemical plants where vinyl chloride emissions were suspected, in areas around the plants, and in other areas of Niagara Falls, The highest concentration of vinyl chloride measured was 40 ppb for a 5-hour integrated sample observed at a residential area two blocks east of a
vinyl chloride polymerization plant. Grab samples taken downwind of
chemical plants exhibited a high of 28 ppb. Samples taken from downtown Niagara Falls and upwind north of the chemical plants
contained no detectable vinyl chloride. The areas surrounding the chemical plants, including the adjacent residential areas, are also
affected by emissions into the atmosphere of chlorine and other halogenated compounds as exhibited by the deterioration of metal
urfaces, particularly aluminum windows and doors*
DESCRIPTORS: Air pollution, *Vinyl chloride, chemical plants. New York, Angiosarcomas, Chlorine organic compounds, Halohydrocarbons, Aluminum, Buildings, Cdrrosion, Sampling, Public health
IDENTIFIERS: Air quality, Niagara Falls (New York), *Air -pollution
sampling.
Air pollution effects (Materia Is), Air pollution
effects(Humans), NTISEPAORD
R&S 040328
Pli-24 3 6 9 5/4 ST NTIS Prices: P*.' 2 j/i'.r i2.2 5
t
Evaluatj on of Vinyl Chloride Associated with Heat Sealing PVC Products
j ronwent&I Health Lab Mcciellan hr a Cf.ni
( 4 ' I 7 O 0 i ')
Final rept. AUTHOR: Smith, Billy S., Burnett, Ronald 0., Diamond, Philip,
Greathouse, Jack E.
C4745F3
FLD: 6J, 57U U SGRDR 7515
Dec 74 70p
REPT NO: EHL-74M-17
PROJECT: HAF-351
MONITOR: 18
ABSTRACT; Potential vinyl chloride (VC) exposures were evaluated during neat packaging and during welding operations using heat to join polyvinyl chloride (PVC) sheets or film. The potential for VC exposure was evaluated by analyzing the pvc materials for entrained or encapsulated VC and by analyzing air samples collected during the meat wrapping and welding operations for VC. The results of all analyses are shown. The potential for erposure to vinyl chlotide monomer at the 0.1 ppm level was not found to exist in either of the two operations
studied. No vinyl chloride monomer was detected in the PVC materials.
DESCRIPTORS:
^Industrial
hygiene,
Exposure (Physiology), Polyvinyl chloride.
processing
* Packaging,
^Welding,
Gas analysis. Heat, Food
IDENTIFIERS; *Vinyl chloride. Indoor air pollution. Gas sampling. Air pollution standards, NTISDODAF
AD-A009 997/8ST NTIS Prices: PC$4.25/MF$2.25
Q5o7 (O
oeeofro
UI
^ixperi me nta) Data Serving as a Basis tor Separate Permissible ^wncc-n trations of D j butylph tlialate
National
Institutes
of Health,
Unit.^Environmental Protection Agency,
Translation Services Section.
AUTHOR: Spasovski, Hincho
C4045C2
FLD: 06J, 06T USGRDR7504
Jul 73 8p
REPT NO: NIH-73-370C
MONITOR: EPA-TR-29-74
Trans. of Khigiena, E pidemiologiya i
p38-44 1964.
Betiiosda, Kd. Translation Research Triangle Park., N.c.
fiikrobiologiya (Bulgaria) v7
ABSTRACT: Based on experiments using animals subjected to single and multiple inhalatory, oral and skincoating dosages, and which are supported by mathematical and analogical methods, the separate permissible standard for concentrations of industrial dibutylphthalate heated above 140C is 0.001 milligrams per liter of atmosphere. The toxicity of dibutylphthalate depends upon the modality of its introduction to the organism. Rost toxic are its fumes heated above 140C which penetrate and consume the lungs. The substance is weakly toxic in oral application. It does not possess skin absorptive capability. Dibutylphthalate possesses a highly cumulative effect in
inhalation and ingestion. The cumulative coefficient falls just short of one, which' explains the hypersensitivity associated with it.
ESCRIPTORS^ . *Phthallates, ^Toxicology, *Plastics, Industrial edicine, Industrial atmospheres. Polyvinyl chloride. Bulgaria, Translations; "Lung, Laboratory animals. Experimental data , Exposure,
Permissible, dosage. Fumes
IDENTIFIERS:- Phthallic acid/(dibutyl-ester), Indoor air pollution, NTISEPAISD, NTISNIH
PB-237 886-T/ST NTIS Prices: PC$3.25/HFS2.25
t--
R&S 040334
accumulation of DI-2-Ethylhexyl Phthalate (DEHP) in Whole Hlood, Platelet Concentrates, and Platelet-Poor pjaswa
Naval Blood Research Lab Chelsea rlass {38>481i AUTHOR: Contreras, T. J,, Sheibley, R. H. , iraleri, c.. R.
C3611I1
FLO: 6L USGRDR 74 24
4 Sep 73 15p
PROJECT: KR041.02
TASK: MfiQ41.02.01
MONITOR: 18
Revision of report dated 30 Mar 73. See also AD-766 554.
Availability: pub. in Transfusion, vl4 nl p34-46 Jan/Feb 74.
ABSTRACT: The concentration of the plasticizer, di-2-ethyIhexyl phthalate (DEHP), in the plasma was measured after storage of the whole blood in polyvinyl chloride plastic bags at 4C for up to 38 days in either ACD or CPD. The plasma from ACD-stored whole blood contained more DEHP than that from CPD-stored whole blood. The continuous-flow centrifugation washing procedures removed about 98 per cent of the DEHP from ACD whole blood stored for 33 days at 4C. DEHP was assayed in the platelet-rich plasma, platelet-poor plasma, supernatant of the platelet concentrate, washed platelets, and washed red blood cells
prepared from CPD whole blood. Very little DEHP was found in the washed red blood cells and platelets, a small amount was found in the platelet-poor plasma, and a large amount in the supernatant of the platelet concentrate. A greater amount of DEHP accumulated in the platelet concentrates that were stored at 22C than in those stored at 4c when platelet concentrates from CPD whole blood were stored at 22c for 72 hours, the amount of DEHP was about four times that observed after 4C storage for the same length of time* (Author)
DESCRIPTORS: *Blood, *phthalates, *plasticizers; *Polyvinyl chloride. Plastics, Bags, Blood plasma. Blood platelets. Accumulation, Blood
banks. Storage, Blood transfusion. Toxicity
IDENTIFIERS: Phthalic acid/bis(ethylhexyl-ester), NTJSDODN
AD-7 66 2 53/5SI. NTIS Price: Reprint
Toxicology of Plastic Devices Having Contact i/ith nlood
Uiali Unix*,.,
Lake City. v- i , i;
..
Interim rept. 24 Aug 72-1 hay 74 AUTHOR: Lyman, Donald J. , Roll,. David B..
C3283I1
FLD: 6T, 6L, 57Y*, S5A*, 95C
Hay 74 206p*
GRANT: PHS-73-2908
HONITOB: NIH/NHLI-73 - 2 90 8-B
Suinvaro, Ewart A. USGRDE74 19
ABSTRACT: The project is primarily concerned with toxicological evaluation of polyvinyl chloride and,, more specifically, the commonly used plasticizer, di(2-ethylhexy1} phthalate {DEHPJ . Evaluations are concentrated on long range, subtle toxicity potential, although basic acute and subacute studies are also utilized. Plastic composition studies, acute toxicity studies, tissue culture studies, subacute toxicity studies, metabolite identification, teratogenic studies, neurologic studies, larger animal studies, analyses of human blood exposed to plastics during hospital procedures, and possible statistical analysis of human patients following extensive exposure of
blood to plastics are included. Selected findings indicate that:
Plastic components which contain DEHP as a plasticizer are toxic to L-929 cells in tissue culture; DEHP appears to prevent implantation of fertilized ova in rats and mice; DEHP affects rate and amplitude of contractions in isolated rat hearts; DEHP is hydrolyzed in vitro by liver microsomes and mitochondria but- not by cytosol.
DESCRIPTORS:
*Polyvinyl
chloride,
^Plastics,
*Toxicology,
Plasticizers, Blood, Medical supplies. Tissue culture, Mechanical
organs. Experimental data, Phthalates, Laboratory animals. Humans,
Bioassay, Neurology
IDENTIFIERS:
*Blood
compatible
materials,
acid/bis (ethylhexyl-ester) , Biomaterials, MTISHEHHLI
*Pathalic
PB-233 701/2 HT IS Prices: p C: jo . V',/[. rs s `*
R&S 040336
5S
Health Hazard Eva lua tion/To xicit y He tens liiation . John Morrell Company, i rj u i. Falls.- So vit h D a kot a
National Insi. for Occupational Siio.-t; an; iieai. ti:s Cincinnati, Ohio. (390 766)
Final rept. Oct 72~Jan 73
A0THOB: Polakoff, Phillip L., Vandervort, Robert
C3084E2
FLD: 6J, 6T, 570, 94D, 66G USGRDB7416
Oct 73 15p
REPT NO: NIOSH-TR-089-74, HHE-71-29-89
MONITOR: 18
ABSTRACT: In response to a request received from a representative of employees, the National Institute for Occupational Safety and Health (NIOSH) conducted a health hazard survey to evaluate exposure to thermal decomposition products of polyvinyl chloride meat packaging film at John Morrell Company, Sioux Falls, South Dakota. Based on medical evidence compiled during a limited study of meat wrapping employees it was determined that air contaminants generated by the thermal cutting of polyvinyl chloride packaging films in conjunction
with the wrapping of meat are potentially toxic to some meat wrapping employees. Symptoms range from mild eye, nose and throat irritation to more serious respiratory problems . for meat wrappers who have an
underlying predisposition to respiratory difficulties. Recommendations have been suggested to management regarding preemployment examinations
and work practices.
DESCRIPTORS: ^Hazardous materials, Industrial medicine, *Polyvinyl -chloride. Toxicity, criteria. Inspection, Standards, Recommendations,
Industrial hygiene. Packaging, Pyrolysis, Respiratory infections
IDENTIFIERS: *0ccupational Safety and Health Act of 1970, Packaging materials, *Meat packing industry, *To-jcic hazards. Air pollution
effects (Humans) , HTISNIOSH
P13- 232 b/L.'ij C/iS Prices:
! '-r-
R&S 040338
t t
" *
Coal Mine Combustion Products: Identification and Analysis
Uitraayst^ws, inc. , Irvine,, Caiii,
.r# j ;
Annual rept. FY 1972-73
AUTHOR: Paciorek, K. L. , Kratzer,
C2314G2
FLD: 7D, 21B, 81,
USGRDR7U06
Aug 73 160p
SEPT NO: SN-8220/A1
CONTRACT: HOI 33004
MONITOR: BuMines-OFR-8-74
R. H., Kaufman, d, , Kekahara, J. 111, 11L, 48A, 710, 99F, 81A,
H. 71R
ABSTRACT: The toxic products formed during thermal oxidative degradation of neoprene and polyvinyl chloride compositions, urethane foams and various untreated and treated woods were determined quantitatively on a g/g basis. Quiescent and dynamic decomposition conditions were employed. Analyses were performed using high vacuum separations, gas chromatography, mass spectrometry, infrared spectroscopy, and wet chemical methods. The main toxic species found were among others CO, HC1, HCN, S02, anhydride, aniline, and furfural. Thermogravimetric analyses were performed on all the compositions, and
the data were correlated to available formulating information and
product formation,
DESCRIPTORS: Combustion products, Plastics, Rood, *Coal mining. Mining equipment, Chloroprene resins. Polyvinyl chloride. Polyurethane resins. Carbon monoxide. Decomposition reactions, Hydcogen chloride, sulfur dioxide. Hydrogen cyanide. Anhydrides, Anilines, Purfurals, Toxicity, Thermal analysis, . Gas chromatography, Hass spectroscopy, Chemical analysis. Oxidation, Safety, organic compounds
IDENTIFIERS: BH
PB-226 944/7 NTIS Prices: PC$11.00/HFS1.4h
040340
^ So
9
Toxicology of plastic Devices Having Contact uith nl ood
Utah Uni v ,, Salt Lake City.
(1*26 400)
Interim rept. for 24 Aug 72-15 Sep 71
AUTHOR: Petersen/. Robert V. , Lyman, David J., Roll, David U. , Swtnard,
Ewart A.
C1901C4
FLD: 6T, 6L, 57Y*, 95A*, 95C 0SG8DR7324
Sep 73 117p*
CONTRACT: NIH-NHLI-73-2908-B
MONITOR: HIH/NHLI-72-6
ABSTRACT: The project is primarily concerned with toxicological evaluation of polyvinyl chloride and, more specifically, the commonly used plasticizer, di(2-ethylhexyl) phthalate (DEHP). The project is divided into twelve tasks including an organizational phase. Plastic composition studies, acute toxicity studies, tissue culture studies, subacute toxicity studies, metabolite identification, teratogenic studies, neurologic studies, larger animal studies, analyses of human blood exposed to plastics during hospital procedures, and possible statistical analysis of human patients following extensive exposure of blood to plastics. Selected findings indicate that: DEHP is poorly absorbed from i, p. = intraperitoneal administration of massive doses; the 30-day subacute i.v. = intravenous LD50 of DEHP in mouse serum is 355 mg/kg in mice; DEHP accumulates in lungs of dogs for at least 2 weeks during daily i.v. = intravenous administration; an efficient m thod for analyzing DEHP by gas chromatography utilizing an internal
standard has been developed; and some components of renal dialysis, and cardiac bypass units are toxic to L929 cells by tissue culture methods. Portions of this -document are not fully, legible.
DESCRIPTORS; {^Plastics, *Blood), (*Toxlcology, Plastics), ( ^Plasticizers, Toxicology) , Medical supplies. Polyvinyl chloride. Addition resins. Elastomers, Thermoplastic resins. Tissue culture, Medical equipment, Mechanical organs. Experimental data, Phthalates,
Bioassay, Humans, Laboratory animals
IDENTIFIERS*.
Phthaiic
a cid bis (eth y Lher y i-e s te r) ,
materials, *Blood compatible materials, NHLI
Biocom ga tir J o
rB-224 558/7 KTlS Prices: PCiU.25/MFJ1.45
R&S 040342
R&S 040344
Cora bust ion Products from the Incineration of Plastics
hie hican Univ., Ann Arbor. School o Public Health.
Pinal rept.
AUTHOR: Boettner, E. A., Ball, G. L., Weise, B.
C1501 A3
FLD: 13B, 7C# 68C*, 68A, 59H USGBDF<7319
1973 154p
CONTRACT: EP-00386
MONITOR: EP A-6 7 0/2-73-049
ABSTRACT: Analysis of the combustion products of plastics was
undertaken to provide scientists and engineers with information needed
to design incinerators in order to maximize their efficiency while
minimizing maintainance and pollution, to identify products of
incomplete combustion potentially recoverable for their fuel or crude
chemical value; and to identify products of incomplete combustion
which would be acutely toxic in an accidental fire. Plastics studied
were polyvinyl chloride, polysulfone, polyurethanes, polyimide, Lopac,
Barex, phenol formaldehyde, urea formaldehyde, polyethylene,
polypropylene,polystyrene, polycarbonate,
polyphenylene oxide,
polyester, synthetic fabrics (Dacron, Orion, nylon), and natural
products (wood and wool). (Modified author abstract)
DESCRIPTORS; (Plastics, Combustion products), (*Air pollution.
Combustion products), (*lnciuerators, Air pollution), (Solid waste
disposal, plastics), Decomposition reactions. Incinerators, Chemical
analysis.
Gas chromatography.
Infrared spectroscopy. Mass
spectrometers. Data, Polyvinylchloride, Thermogra vine trie analysis,
Polyurethane resins, Polyimide resins, urea formaldehyde
resins,
Polyethylene,
Polypropylene, Polystyrene, polycarbonate resins,
Polyester resins
IDENTIFIERS: NERC
PB-222 001/0 HITS Prices: PC$8.00/hPS1.95
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Chemical and physical, properties and Thermal Peconposi tion Products of
Certain natural products and b yn t i. <- j c iia rials
Environmental Health tab Kelly APB Tex (jOObJbj
Technical rept.
AUTHOR: Helvin, Halter H.
C0072I2
FLD: 111/ 11E,
Hay 72 170p*
BEPT NO: EHL(K)-72-14
PROJECT: EHL-70-7
HOHITOR: 18
Jr 1 3L,,
710,
71H,
711,
83C
(JSGRDB730 2
ABSTRACT: A limited review of the literature inciudiug the early history and current data on deaths, injuries and costs due to the combustion and pyrolysis of resins, plastics and natural materials is provided.There is a limited discussion of the chemistry and physical properties of plastics. Applications of these materials in wearing apparel, construction trades, the aircraft industry, and others are discussed. Experimental data on the pyrolysis products of five synthetic and natural fiber carpets are presented. An extensivf collection of tables from a number of sources give data on the trad name, type of plastic and manufacturer, physical and chemica properties, decomposition products, and other information. (Author)
DESCRIPTORS: (*Plastics, *Combustion), (*Textiles, Combustion), ( Floor coverings. Combustion), Reviews, Burning rate. Toxicity, Clothing, Nylon, Corrosive gases. Fire resistant materials, pyrolysis. Thermal properties, Roolen textiles, polyvinyl chloride, plasticizers.
Carbon monoxide
IDENTIFIERS: Fire safety, *Carpets, *Flammability testing. Smote, Hydrogen chloride. Hydrogen cyanide
AD-751 899 NTIS Prices: PC$3. OO/HFSO. 9 5
040346
t
ON THE QUESTION OF IMPROVING SOME POLYVINYL CHLORIDE POLYMERS AND A
METHOD OF IMPROVING THEIR TOXICITY
Air Force Systems Command, Wright- Pal verson APB, Ohio.
Technology Div.
AUTHOR: Gorban, G. M.
6011F1
FLD: 11G STAR0709
Apr 68 13p
KEPT NO: AD-680924, FTD-HT-23-1464-67
Tran- Transl, Into English From Kosmich. Biol. MecL (USSR),
2, 1967 P 47-51
Fcrei<n. V. 1, No,
DESCRIPTORS: ^Electrical properties, *Plastic tapes, ^Polyvinyl chloride, Ureas, Degassing, Electrical insulation. Nitrogen compounds
N69-20342 CFSTI Prices: PCS3.00 MFS0.95
ABSTRACT:
A method is developed for improving the polyvinyl chloride tapes for the purpose of decreasing their gas emanation. The overall gas emission of organic substances from the improved specimens of polyvinyl chloride tapes as a result of the treatment with 50% urea solution is reduced by a factor of 2-1 (2. The improved polyvinyl chloride tapes give off volatile chemical substances in small concentrations, which with long duration of their action on the organism cause only a weak biilogical effect. Asa result of the treatment with a solution of urea there is an improvement in the electrical insulation properties of the polyvinyl chloride tapes serving the purpose for which the materials are intended without change in their strength characteristics.
oa
So
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40348
ON THE QUESTION OF IK PRO VING SOME POLYVINYL CHLOKIDE POLYMERS AND A METHOD OF IMPROVING THEIR TOXICITY
Foreign Technology Div wright-Patterson AFB Ohio
AUTHOR: Gorban, G. M., Yablochkin, v. D.
5603E1
FLD: 111, 22A USGRDR6906
15 Apr 68 12p
BEPT NO: FTD-HT-23-1464-67
Unedited rough draft trans. of Kosaicheskaya
(USSR) y 1 n2 p47-51 1967, by E. Harter.
(141600} Biologiya i
fleditsina
ABSTRACT: A method is developed for improving* the polyvinyl chloride tapes for the purpose of decreasing their gas emanation. The overall gas emission of organic substances from the improved* specimens of polyvinyl chloride tapes as a result of the treatment with 50% urea solution is reduced by a factor of 2 1/2. The `improved* polyvinyl chloride tapes give off volatile chemical substances in small: concentrations, which with long duration of their action on the organism cause only a weak biological effect. As a result of the treatment with a solution of urea there is an improvement in th electrical insulation properties of the polyvinyl chloride tapes serving the purpose for which the materials are intended without
change in their strength characteristics. (Author)
DESCRIPTORS; (*Polyvinyl chloride. Processing), Tapes, Gases, Urea, Spacecraft cabins. Carbon dioxide. Aldehydes, Carbon monoxide.
Hydrocarbons, Toxicity, Degasification, USSR
IDENTIFIERS; Translations
,"
AD-680 92 CFSTI Prices: PCS3.00 HFS0.95
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