Document QXamrjmqV1konybYOe0XK976E
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FINAL REPORT Epidemiology, 220-3W-05
Medical Department 3M Company
St. Paul,MN 55144
Date: March 19,2001
Title: Descriptive Summary of Serum Fluorochemical Levels among Employee Participants of the Year 2000 Antwerp Fluorochemical Medical Surveillance Program
Study Start Date:
March 1,2000
Protocol Number (not applicable) IRB Approval
Exempt Expedited X
IRB Approval Date: (not applicable as these data are from a medical surveillance
program)
Principal Investigator:
Geary W. Olsen, D.V.M., Ph.D.'
Co-investigators:
Marie-Noelle Schmickler, M.D.2 Johan M. Tierens, M.S.2 Perry W. Logan, M.S.3 Jean M. Burris, R.N., M.P.H.' Michele M. Burlew, M.S.' James K. Lundberg, Ph.D.4 Jeffrey H. Mandel, M.D., M.P.H.'
Study Director:
Jeffrey H. Mandel, M.D., M.P.H.'
1. 3M Medical Department, 220-3W-05, St. Paul, MN 55144-1000 2. 3M AAwerp Plant, Canadastraat 11, Haven 1005,2070 Zwijndrecht, Belgium 2. 3M Decatur, EHS&R, P.O. Box 2206, Decatur, Alabama 35609-2206 4. 3M Environmental Laboratory, 2-3E-01, St. Paul, MN 55144-1000
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3M Company Page 2 of 36 ABSTRACT Serum fluorochemical levels were measured for 258 Antwerp chemical plant, laboratory and administrativeemployees during the year 2000 fluorochemicalmedical surveillanceprogram. Overall, the geometric mean (95%confidenceinterval in parenthesis)for perfluorooctanesulfonate (PFOS) was 0.44ppm (95%CI 0.38-0.51) and for perfluorooctanoate (PFOA) was 0.33 ppm (95%CI 0.27-0.40). An analysisof these self-reported data of the workplace questionnaire in conjunction with the employees' serum fluorochemical levels suggested that the greatest potential for workplaceexposure to POSF-based chemicals occurred in Building 03 and to peffluorooctanoic acid in the glass unit in Building 16. For example, Building 03 operators had a geometric mean serum PFOS level of 1.66 ppm (1.40-1.97ppm) and a geometric mean serum PFOA level of 1.55 pprn (1.46-1.73 ppm). There were three employees whose serum PFOA levels
exceeded the 3M Biological Limit Value (BLV) of 5 ppm (range 5.15 - 7.04 ppm).
These three individualsoften worked as shift operatorsin the Building 16 glass unit. The next four highest serum PFOA levels were also for individuals who were shift operators in Building 16, but only one of these employees self-reportedthat he often worked in the glass unit area. Administrativeand laboratory workplace areas resulted in geometric mean employeeserum PFOS and PFOA levels (< 0.5 ppm, on average) that were lower than those observed in the production areas.
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3M Company Page 3 of 36 INTRODUCTION The 3M Antwerp fluorochemical medical surveillance program is conductedon a biennial basis. Prior to 1995, total organic fluorine was measured. Serum perfluorooctanesulfonate (PFOS) and peffluorooctanoate (PFOA) were assayed in 1995 and 1997 at the Antwerp facility (Olsen et al, 1999). Provided below is a brief description of the 3M Antwerp manufacturing facility.
Antwerp Manufacturing,Facility F'luorochemical production at the 3M Antwerp manufacturing facility occurs
primarily in three buildings: Buildings 03, 16 and 32. Building 02 is the warehouse. Building 04 is the plant maintenance department. Building 01 includes administrative offices and laboratories. At the time of the surveillanceexams, the approximatenumber of production employees included: Building 03 (N = 70); Building 16 (N = 30); Building 02 (N = 22); Building 04 (N = 30) and Fluorel (including operationsin Buildings03 and 32; N = 34). Most production employees work in an 8 hour, 4 crew shift system.
Several products are manufactured in Building 03. Three product groups can be distinguishednon-fluorochemical,fluorochemical and synthetic fluoroelastomers. Non fluorochemicalproduction involves primarily batch processes located in the old part of the building. These process include 1) fenol resins; 2) acrylate polymers and adhesives;3) polyurethane polymers; and 4)acrylates. Fluorochemicalproduction primarily involves batch processes located in the new part of the building. All of these products Kave perfluoroctanesulfonyl fluoride (POSF) as a starting material. The sulfonyl group of POSF is a reactive group that is reacted to fluorochemical amines and
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then further to other fluorochemcialsincluding alcohols and acrylates. Within the fluorochemical production are intermediate products, end products, inerts and surface active productions (one of which is a purification process for PFOA, another is the flaker process in which fluorochemical polyacrylates based on POSF are being flaked.) Other fluorochemical products are foam extinguishingagents. Synthetic fluoroelastomers (called Fluorel rubbers) are semi-batch processes. The Fluorel rubber is a fluorinated
elastomer based on hexafluoropropylene(HFP)and vinylidenefluoride(VF2).
i Building 16 primarily manufactures base products for fluorochemicals (PFOS and PFOA). Besides these main end products, there are manufactured side streams (inerts) which are purified to commercial grade products. In the manufacturing of base products for fluorochemicals, two main processes can be distinguished: 1) continuous water chlorination in which mercaptans are modified to sulfonylchlorides;and 2 ) hydrogen fluoride (HF)electroperfluorination. The latter is an electrochemicalperfluoroination
process that takes place in anydrous HF.Within the HF electroperfluorinationthere are
two product groups: a) perfluorosulfonylfluorides; and b) peffluorooctanoic acid. Some of the perfluorooctanoic acid is extra purified in Building 03 and further purified and reacted in Building 16 to ammonium perfluoroocatanoate. This is done in the glass unit in a separate section of the building.
In Building 32, the Fluorel rubbers are further treated on a rubber mill (calander). Additives are added and blended on the mill. This process was formerly only done in one section of the warehouse (Building 02) where the old mill is still operational.
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Study Purpose The purpose of this report is to provide the results from the year 2000 Antwerp
fluorochemicalmedical surveillance program. Observations are reported in relation to some of the above Buildings and production processes.
METHODS The fluorochemicalmedical surveillanceprogram is available, on a voluntary
basis, to 3M Antwerp production, warehouse, maintenance,research and administrative employees. Approximately340 employeeswere eligible to participate; 258 (75%) chemical plant and site employees participated. In addition to the fluorochemicaltesting program, a standard battery of clinical chemistry and pulmonary function tests were performed on employees along with a brief medical history questionnaire. A group analysis of the clinical data will be reported in conjunctionwith employeedata from the Decatur manufacturingplant's fluorochemical medical surveillanceprogram that was also completed in 2000. This report focuses solely on the employees' serum fluorochemical levels in relation to self-reportedresponsesfrom a work history questionnaire(see Appendix A)'that was administered at the time of the blood collection in the Spring, 2000.
Sera samples were extracted using an ion-pairing extraction procedure. The extracts were quantitativelyanalyzed for PFOS (perfluorooctanesulfonate),PFOA (perfluorooctanoate),PFHS (perfluorohexanesulfonate),PFOSAA (N-ethyl perfluoro&anesulfonamidoacetate), M570 (N-methyl perfluorooctanesulfonamidoacetate), PFOSA (perfluorooctanesulfonateamide)and M556
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(perfluorooctanesulfonamidoacetate)using high-pressure liquid
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chromatography/electrospray tandem mass spectrometry (HPLUESMSMS) and
evaluated versus an extracted curve from a human serum matrix. Endogenous levels of
certain fluorochemicalswere determined in the standard serum matrix and additional
fluorochemical was spiked into the matrix. The total amount of each specific
fluorochemical(endogenous + spiked)was used to construct an extracted standardcurve.
All serum fluorochemical analyses were determined by Northwest Bioanaltyical
Laboratory Inc. (Salt Lake City, UT).
Employeework history questionnairedata were computerized. Because of the
inconsistencyof responses to some of the historical questions, the analyses in this report
focused on the employees'answers to questions2,3,5,6,7,8,9 and 10 (see Appendix
A). Because the serum distributionsfor PFOS, PFHS, PFOA, PFOSAA, M570,
PFOSA and M556 appeared log normally distributed (see Figures 1 and 2 for PFOS and
PFOA), natural log transformations of the fluorochemicalswere performed to calculate geometricmeans [e(sumInxyn)] and 95%confidence intervals were calculatedfor the
geometricmean. The random variable X is said to have a log normal distributionif log X
is normally distributed,that is, if X is of the form e' where Y is normal (i.e., the normal
bell shaped curve). The pertinent properties of a log normal distributioncan then be
derived from properties of the normal distribution. The mean and variance are of the
normally distributed Y, that is, of log X.
Alfemployee serum values for PFOS and PFOA were above the respective lower
limit of quantitation (LLOQ). There was one employeewith a PFHS value below the
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3M Company Page 7 of 36 LLOQ (0.0027ppm) and one employee with a M570 below the LLOQ (0.0057 ppm). There were 111 employees with PFOSAA values below the LLOQ (0.006 ppm); 88 employeeswere below the LLOQ (0.001 ppm) for PFOSA; and 13employees were below the LLOQ (0.0043 ppm) for M556.. For statisticalpurposes, serum fluorochemical values that were less than the LLOQ were assumedto be at the midpoint between zero and the LLOQ. Therefore, for those employees with serum values reported at the LLOQ for PFHS, M570,PFOSAA, PFOSA and M556, they were assigned for calculationsin this report the values of 0.00135 ppm, 0.00285 ppm, 0.003 ppm, 0.0005 ppm and 0.00215 ppm, respectively. All fluorochemical measurements were reported in parts per million (ppm) to the second decimal point (or to the 3rdor 4" decimal point if the LLOQ was at the 3rddecimal point).
RESULTS Provided in Table 1 are the demographiccharacteristicsof the 258 Antwerp
employeeswho participatedin the year 2000 fluorochemicalmedical surveillance program. Eighty-one percent were males. Regardless of gender, the average years worked was 12 years.
The arithmeticmean, range, geometric mean and 95%confidenceinterval of the
geometric mean of the serum fluorochemicallevels for all Antwe-rp employees
participating is shown in Table 2. The arithmetic mean was generally twice as high as the geometric mean. The highest serum PFOS value measured was 6.24 ppm. The highest sdhm PFOA value measured was 7.04 ppm.
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3M Company Page 8 of 36 Presented in Tables 3 and 4 are the serum fluorochemical levels by production, maintenance, warehouse, administration and laboratory areas. Results are analyzed for those employees who self-reported that they solely worked in these areas; thus there is minimum amount of current workplace crossover experience presented in these data. It is possible that these workers may have prior experience in other areas. Working in Building 03 provided, in general, the highest employee serum levels for PFOS, PFHS, PFOSAA, M570 and M556. Working in Building 16 had comparableserum PFOA levels to employees who worked in the new section in Building 03. Fluorel workers,
maintenance employees, laboratory QA and RD workers and administrativeworkers had
lower serum fluorochemicallevels. It should be noted that LaboratoryQA workers, on
average, had higher serum fluorochemical levels than laboratory R&D workers.
Analysis of serum fluorochemicallevels by job type (Building03 operator,fluorel operator,Building 16 operatoror Building 02 warehouseman) provided similar results (Table 5 ) to those observed by department analyses (Tables 3 and 4). The analysis of maintenance workers showed higher serum fluorochemical levels, on average, for mechanicsthan electriciansor boiler operators (Table 6). Geometric mean PFOS and PFOA levels were higher for process engineersthan non process engineers (Table 7). Supervisorshad two-fold and higher serum PFOS and PFOA levels compared to managers.
The analysis of those employees who reported that they worked > 50% or 30-50% of their time in Building 03 production areas showed that the higher serum PFOS and PFOA le6els were among those employeeswho worked 50% or more time in the FC alcohol, internal chemical and flaker areas compared to those who worked in ground
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3M Company Page 9 of 36 floor drumming and fluorel (Table 8). Similar results were observed for PFHS, PFOSAA, M570 and M556.Analyses were not shown for those employees who selfreported they worked <30%time in a given area as these individuals may have had higher serum fluorochemicallevels as a consequenceof their other assignments(those that made up 70% of their time). Provided in Table 9 are the self-reported results for those employeeswho worked in Building 16. Building 16employeeswho did not work in the glass unit had much lower serum PFOA levels (geometricmean 0.59 ppm) than shift operators who often worked on the glass unit (geometricmean 4.71 ppm) or for shift operatorswho sometimesworked in the glass unit (geometricmean 1.65ppm). However, all employees in Building 16 had comparable serum PFOS levels. Restrictingthe analysisto those employeeswho had the greatest potential for workplace fluorochemicalexposure (Building03 and 16 operators, fluorel operators and waste treatment operators), a negative association was not observed between serum fluorochemicallevels and frequency of launderingclothes (Table 10)or taking showers at the workplace after work (Table 11).
DISCUSSION The year ZOO0 Antwerp fluorochemicalmedical surveillanceprogram had the
greatest number and highest percentage of employee participants in the history of the program at Antwerp. An analysis of the self-reported results from a workplace questionnairein conjunction with the employeesserum fluorochemical levels provided strong evGence that the greatest potential for workplace exposure to POSF-based chemicalsat Antwerp occurs in Building 03. For perfluorooctanoicacid, the greatest
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potential occurs in the glass unit in Building 16. Administrativeand laboratory workplace areas resulted in serum PFOS and PFOA levels that were lower than those observed in the production areas.
There were three employees who had serum PFOA levels greater than the 5 ppm Biological Limit Value (BLV) that was establishedby the 3M Exposure Guideline committee in 2000. The highest value was 7.04ppm. These three employees selfreported that they often worked as shift operators in the glass unit area in Building 16. Employees with the next 4 highest serum PFOA levels (range 3.65-4.19 ppm) also worked as shift operators in Building 16 but only one self-reported that he often worked in the glass unit.
Prior to the initiation of the year 2000 Antwerp fluorochemical medical surveillanceprogram, there were employeecommunication meetings regardingthe toxicology of peffluorooctanyl chemistry and industrial hygiene findings and recommendations. Employeeswho participatedin the year 2000 fluorochemicalmedical surveillanceprogram received a personal letter which provided them their individual results for the 7 fluorochemicalsmeasured. Group employeecommunicationsoccurred in January an'd February, 2001 where the analyses, described in this report, were presented. Industrial hygiene sampling data were also discussed.
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REFERENCES
Olsen GW, Burris JM, Mandel JH, Zobel LR (1999). Serum perfluorooctane sulfonate
and hepatic and lipid clinical chemistry tests in fluorochemcialproduction employees. JOEM 41(9):799-806.
,
35
i
30
25
ua)l
-E2 20
Lu 0
P'i 15
E
z 3
10
5
0
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Figure 1 Year 2000 Antwerp FluorochemicalMedical Surveillance
Number of Employees (N = 258) by Serum PFOS Levels (ppm) (Each x axis tick = 0.1 ppm)
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1
80
\
70
60
f* 50
0
-; Lrc' 40
0
t
P
E 30
20
10
0
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Figure 2. Year 2000 Antwerp Fluorochemical Medical Surveillance
Number of Employees (N = 258) by Serum PFOA Levels (ppm)
(Each x-axis tick represents 0.1 ppm)
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I I PFOA
I I4 I I IIIl ~ . I I111I1, ,
I
I I I I 11'1
I IA
Serum PFOA (ppm)
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TABLE 1
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Demographics of Antwerp Employees who Participated and Self-Rpoerted this Information in theyear 2000 Fluorochemical Medical SurveiIlance Program
Gender
Age (years)
Average Years Worked
Work Schedule 4 Shift System (4-ploegensy steem)
Daily (dagdienst)
Relief
QA 5 Shift System (QA 5-ploegensysteem)
Did not schedule
Males 209 (81%) 37.3
12.7
101 (100%)
88 (65%)
6 (1 00%) 7 (88%)
7 (100%)
Females 49 (19%) 35.8 12.3
0 (0%)
48 (35%)
0 (0%) 1 (12%)
0 (0%)
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TABLE 2
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Year 2000 Antwerp FluorochemicalMedical SurveillanceProgram
Arithmetic Mean, Range, GeometricMean and 95% ConfidenceInterval of Serum FluorochemicalLevels (ppm)
N = 258 Employees
Fluorochemical'.-. PFOS PFOA PFHS PFOSAA M570 PFOSA M556
Arithmetic Mean 0.80 0.84 0.17 0.02 0.15 0.001 0.03
Range
0.04 - 6.24
0.01 - 7.04
0.001 - 1.43 0.003 - 0.14
0.003 - 1.06 0.0005 - 0.008
0.002 - 0.48
Geometric Mean 0.44 0.33 0.07 0.009 0.06 0.0007 0.01
95% Confidence Interval 0.38 - 0.51 0.27 - 0.40 0.06- 0.08 0.008 - 0.01
0.05 - 0.07
0.0007 - 0.0008
0.0009 - 0.01
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TABLE 3 Year 2000 Antwerp Fluorochemical Medical Surveillance Program
3M Company Page 16 of 36
Arithmetic Mean, Range, Geometric Mean and 95% Confidence Intervals of Serum Fiuorochemical Levels (ppm)
for Production and Maintenance Operations
\
PFOS Arithmetic Mean Range
Geometric Mean 95% C.I. PFOA Arithmetic Mean Range
Geometric Mean 95% C.I. PFHS Arithmetic Mean Range
Geometric Mean 95% (2.1. PFOSAA Arithmetic Mean Range
Geometric Mean 95% C.I.
Building 3 (Both Sections) ,
Gebouw 03 (beide gedeelten)
N=24
Building 3 Old Section Gebouw 03 Oud gedeelte
N=8
Building 3 New Section Gebouw 03 Nieuw gedeelte
N = 17
Building 16 Gebouw 16
N=27
1.29
0.29 - 2.46
1.1 1 0.86 - 1.43
1.85 0.57 - 3.25
1.68
1.16 - 2.41
2.48
0.04 - 6.24
2.14 1.58- 2.88
0.54
0.21 - 1.37
0.49 0.42 - 0.59
1.32 0.32 - 1.83
1.22 1.11- 1.48
1.34 0.40 - 1.89
1.23 1.03- 1.75
2.05
0.79 - 3:59
1.93 1.75 - 2.32
2.56 0.10 - 7.04
1.93
1.62 - 2.73
0.26
0.02 - 0.76
0.20
0.14 - 0.28
0.38 0.07 - 0.75
0.28 0.15 - 0.54
0.47
0.03 - 1.37
0.35 0.22 - 0,55
0.27
0.03 - 0.90
0.16 0.10 - 0.25
0.03
Oa.003 - 0.07
0.03
0.02 - 0.04
0.04 0.01 - 0.05
0.04 0.03 - 0.05
0.05
0.03 - 0.12
0.05
0.04 - 0.06
0.009 0.003 - 0.11
0.004
0.003 - 0.006
Fluorel N=20
Maintenance Onderhoudsafdeling
N=22
0.51
0.11 - 1.21
0.43 0.32 - 0.57
0.73 0.06 - 1.90
0.53
0.36 - 0.79
0.63 0.03 - 2.32
0.41
0.32 - 0.69
v
0.08 0.009 - 0.48
0.06 0.03 - 0.07
0.64 0.02 - 2.37
0.40 0.31 - 0.68
0.11 0.004 - 0.39
0.06 0.03 - 0.10
0.04 . 0.003 - 0.14
0.02 0.01 - 0.04
0.01 0.003 - 0.048
0.01 0.007 - 0.02
M570
Arithmetic Mean
Range
\
Geometric Mean
95% C.I.
PFOSA Arithmetic Mean Range
Geometric Mean
95% C.I.
M556 Arithmetic Mean Range
Geometric Mean
95% C.I.
TABLE 3 (continued)
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0.38
0.02 - 0.76
0.30
0.20 - 0.45
0.43
0.09 - 0.59
0.38
0.25 - 0.59
0.53
0.30 - 1.06
0.5 1
0.43 - 0.59
0.06
0.01 - 0.42
0.03
0.02 - 0.04
0.07 0.01 -0.14
0.06 0.04 - 0.08
0.002 0.0005 - 0.006
0.001 0.001 - 0.002
0.002 0.0005 - 0.004
0.002
0.001 - 0.003
0.003 0.0005 - 0.007
0.003
0.002 - 0.004
0,0006 0.0005 - 0.001
0.0005
0.0005 - 0.0006
0.002 0.0005 - 0.008
0.001
0.0007 - 0.002
0.09
0.002 - 0.17
0.06 0.04 - 0.10
0.11
0.01 - 0.18
0.08 0.04 - 0.16
0.16
0.06 - 0.48
0.14 0.11 -0.18
0.01
0.002 - 0.08
0.004 0.003 - 0.007
0.01 0.002- 0.05
0.01 0.007 - 0.02
0.14 0.01 - 0.50
0.10 0.07 - 0.14
0.0006 0.0005 - 0.002
0.0006 0.0004 - 0.0007
0.03 0.002 - 0.07
0.02 0.01 - 0.02
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TABLE 4
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Year 2000 Antwerp Fluorochemical Medical Surveillance Program Arithmetic Mean, Range, Geometric Mean and 95% Confidence Intervals of Serum Fluorochemical Levels (ppm)
for Warehouse, Administrative and Laboratory Operations
\
PFOS Arithmetic Mean Range
Geometric Mean 95% C.I. PFOA Arithmetic Mean Range
Geometric Mean 95% C.I. PFHS Arithmetic Mean Range
Geometric Mean 95% C.I. PFOSAA Arithmetic Mean Range
Geometric Mean 95% c.1.
.
Building 2 Warehouse Gebouw 02 Magazijn
N=20
1.19 0.13 -4.13
0.78 0.50 - 1.23
0.3 0.05 - 0.66
0.26
0.22 - 0.38
0.25
0.007 - 1.43
0.13
0.07 - 0.24
0.03
0.003 - 0.07
0.02
0.01 - 0.03
Administrative Administratie
N=46
0.24 0.04 - 1.76
0.15
0.12 - 0.19
0.15 ' 0.01 - 1.78
0.05
0.04 - 0.07
0.04
0.001 - 0.39
0.02
0.01 - 0.03
0.005 0.003 - 0.06
0.004 0.003 - 0.004
Laboratory QA Laboratorium QA
N = 17
0.45 0.10- 1.74
0.37 0.28 - 0.49
0.5 1
0.07 - 1.39
0.38 0.30 - 0.57
0.09 0.01 - 0.35
0.07 0.04-0.10
0.01 0.003 - 0.03
0.008 0.006 - 0.01
Laboratory R&D Laboratorium R&D
N=23
0.29
0.07 - 1.28
0.21
0.15 - 0.30
0.16
0.02 - 0.85
0.10 0.08 - 0.15
0.07 0.003 - 0.35
0.04
0.02 - 0.06
0.006
0.003 - 0.06
0.004 0.003 - 0.005
M570 Arithmetic Mean Range j
Geometric Mean 95% C.I.
PFOSA Arithmetic Mean Range
Geometric Mean 95% C.I.
M556 Arithmetic Mean Range
Geometric Mean 95% C.I.
TABLE 4 (continued)
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3M Company Page 19 of 36
0.16
0.04 - 0.~8
0.13 0.09- 0.18
0.0005
0.0005 - 0.001
0.0005
0.0004- 0.0006
0.03
0.005 - 0.09
0.02
0.02 - 0.03
0.03
0.007- 0.57
0.02
0.01- 0.02
0.0006
0.0005- 0.005
0.0005 0.0005- 0.0006
0.01 0.002- 0.26
0.003
0.003- 0.004
0.07 IL.02 - 0.22
0.05
0.04 - 0.08
0.0005 0.0005- 0.0005
0.0005
0.0005- 0.0005
0.01
0.002- 0.04
0.008 0.005- 0.01
0.03 0.003- 0.
0.02 0.02 - 0.03
0.0006
0.0005- 0.002
0.0005
0.0005- 0.0006
0.005 0.002- 0.02
0.004
0.003 - 0.005
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TABLE 5
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Year 2000 Antwerp Fluorochemical Medical Surveillance Program Arithmetic Mean, Range, GeometricMean and 95% ConfidenceIntervals of Serum Fluorochemical Levels (ppm)
for Production and Warehouse Jobs (as self-reported on quesitonnaire)
\
PFOS Arithmetic Mean Range
Geometric Mean 95% C.I. PFOA Arithmetic Mean Range
Geometric Mean 95% C.I. PFHS Arithmetic Mean Range
Geometric Mean 95% C.I. PFOSAA Arithmetic Mean Range
Geometric Mean 95% C.I.
Building 3 Operator Gebouw 03 Operator (incl chief) N=45
1.92 0.40 - 6.24
1.66
1.40 - 1.97
1.65 0.40 - 3.59
1.55
1.46 - 1.73
0.37 0.03 - 1.37
0.27 0.21 - 0.36
0.04 0.003 - 0.11
0.04
0.03 - 0.05
Fluorel Operator N = 17
0.56 0.16 - 1.21
0.5 1 0.41 - 0.64
0.73 0.06 - 2.32
0.59
0.50 - 0.86
0.09 0.01 - 0.48
0.06 0.04 - 0.09
0.04
0.003 - 0.14
0.03
0.02 - 0.05
Building 16 Operator
Gebouw 16 Operator N=25
0.55
0.21 - 1.37
0.49 0.41 -0.59
2.69 0.10 - 7.04
2.07
1.73 - 2.96
0.28 0.03 2 0.90
0.16
0.10 - 0.25
0.009
0.003 - 0.11
0.004 0.002 - 0.006
Building 2 Warehouseman
Gebouw 02 Magazijnier
N = 16
1.43 0.18 -4.13
1.10 0.74 - 1.63
0.39 0.05 - 0.66
0.35 0.30 - 0.47
0.30 0.02- 1.43
0.20 0.12 - 0.32
0.03
0.008 - 0.07
0.03 0.02 - 0.04
M570 Arithmetic Mean Rangef. ..
Geometric Mean 95% C.I.
PFOSA Arithmetic Mean Range
Geometric Mean 95% C.I.
M556 Arithmetic Mean Range
Geometric Mean 95% C.I.
TABLE 5 (continued)
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3M Company Page 21 of 36
0.47
0.02- 1.06
0.42
0.35- 0.51
0.003
0.0005- 0.007
0.002
0.001 - 0.003
0.12
0.002- 0.48
0.10 0.08 - 0.13
0.08 0.02- 0.14
0.07
0.06- 0.09
0.002
0.0005- 0.008
0.001 0.0008- 0.002
0.02 ' 0.002- 0.05
0.01 0.009 - 0.02
0.06
0.01- 0.42
0.03
0.02- 0.04
0.0005 0.0005- 0.001
0.0005
0.0005- 0.0006
0.01 0.002- 0.08
0.005
0.003- 0.007
0.19 0.04- 0.41
0.16 0.12- 0.22
0.0005
0.0005- 0.001
0.0005 0.0005- 0.0006
0.04 0.005 - 0.09
0.03 0.02 - 0.04
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TABLE 6
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Year 2000 Antwerp Fluorochemical Medical Surveillance Program Arithmetic Mean, Range, Geometric Mean and 95% Confidence Intervals of Serum Fluorochemical Levels (ppm)
for Maintenance Workers
\
PFOS Arithmetic Mean Range
Geometric Mean
95% C.I.
PFOA Arithmetic Mean Range
Geometric Mean
95% C.I.
PFHS Arithmetic Mean Range
Geometric Mean
95% C.I.
PFOSAA Arithmetic Mean Range
Geometric Mean
95% C.I.
Mechanic Mekanicien
N = 10
1.50
0.39 - 4.86
1.19
0.77 - 1.84
1.24
0.36 - 3.33
0.98
0.78 - 1.54
0.26
0.03 - 0.97
0.17
0.09 - 0.32
0.03 0.009 - 0.05
0.02
0.01 - 0.03
Electrician Electricien
N=9
0.53 0.29 - 1.06
0.47
0.33 - 0.67
0.47 0.13 - 0.95
0.38 0.30 - 0.63
0.07
0.02 - 0.22
0.05 0.03 - 0.09
0.01
0.003 - 0.02
0.009
0.006 - 0.01
Boiler Operator Boiler Operator
N=2
0.33 0.20 - 0.46
0.30 0.13 - 0.70
0.21 0.21 - 0.21
0.21 0.21 - 0.22
0.05
0.01 - 0.08
0.03
0.004 - 0.23
0.008
0.007 - 0.009
0.008 0.007 - 0.01
M570 Arithmetic Mean Range j,.,
Geometric Mean 95% C.I.
PFOSA Arithmetic Mean Range
Geometric Mean 95% C.I.
M556 Arithmetic Mean Range
Geometric Mean 95% C.I.
TABLE 6 (continued)
BACK TO MAIN
3M Company Page 23 of 36
0.25
0.07 - 0.54
0.21
0.14- 0.32
0.0009 0.0005- 0.002
0.0007
0.0004- 0.001
0.05
0.008- 0.14
0.03 0.02- 0.06
0.11 0.04- 0.31
0.09 0.05 -0.15
0.0006 0.0005- 0.001
0.0006
0.0004- 0.0007
0.02 0.005- 0.06
0.01 0.008- 0.03
0.07 0.05- 0.08 .
0.07
0.04- 0.11
0.0005 0.0005- 0.0005
0.0005 0.0005- 0.0005
0.008
0.007- 0.009
0.008 0.006 - 0.01
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TABLE 7
3M Company Page 24 of 36
Year 2000 Antwerp Fluorochemical Medical Surveillance Program Arithmetic Mean, Range, Geometric Mean and 95% Confidence Intervals of Serum Fluorochemical Levels (ppm)
for Engineers, Laboratory Workers and Administrators
\
'. Administration Process Engineer Administratie Proces Ingenieur N = 11
PFOS Arithmetic Mean Range
0.32
0.07 - 0.62
Administration Not Process Engineer
Administratie Niet Proces Ingenieur
N=39
0.20 0.04 - 1.76
Laboratory QC/QA Laboratorium QC/QA
N = 17
Laboratory R&D Laboratorium R&D
N=20
0.45 0.10 - 1.74
0.32 0.04 - 1.28
Geometric Mean 95% C.I.
PFOA Arithmetic Mean Range
0.26
0.17 - 0.40
0.38
0.04 - 1.78
0.12 0.10-0.16
0.10
0.01 - 1.78
0.38
0.28 - 0.50
0:50 0.07 - 1.39
0.22 0.15 - 0.33
0.17
0.02 - 0.85
Geometric Mean
95% c.1.
PFHS Arithmetic Mean Range
0.23 0.17 - 0.44
0.04 0.005 - 0.08
0.04 0.03 - 0.05
0.03
0.001 - 0.39
0.36 0.29 - 0.56
0.08
0.01 - 0.36
0.11 0.09 - 0.17
0.08
0.003 - 0.35
Geometric Mean 95% C.I.
PFOSAA Arithmetic Mean Range
0.03 0.02 - 0.05
0.007 0.003 - 0.02
0.01
0,009- 0.02
0.005 0.003 - 0.06
0.06 0.04'- 0.09
0.01
0.003 - 0.03
0.04 0.02 - 0.07
0.006
0.003 - 0.06
Geometric Mean 95% C.I.
0.006 0.004 - 0.008
0.004
0.003 - 0.005
0.009
0.006 - 0.01
0.004 0.003 - 0.005
Supervisor Supervisie
N = 11
0.72 0.09 - 1.97
0.53 0.31 - 0.90
0.66 0.04 - 1.83
0.42 0.30 - 0.82
0.20 0.02 - 0.45
0.13 0.07 - 0.25
0.01 0.003 - 0.03
0.009 0.005 - 0.01
Management
N = 11
0.34 0.10- 1.40
0.24 0.15 - 0.39
0.13
0.02- 0.46
0.09
0.06- 0.15
0.09
0.007- 0.16
0.06
0.04 - 0.12
0.004
0.003 - 0.01
0.004 0.003 - 0.005
TABLE 7 (continued)
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Page 25 of 36
M570
Arithmetic Mean
Range
1
Geometric Mean 95% C.I.
PFOSA Arithmetic Mean Range
Geometric Mean 95% C.I.
M556 Arithmetic Mean Range
Geometric Mean 95% C.I.
0.06 0.02 - 0.21
0.04
0.03 - 0.07
0.0005
0.0005- 0.001
0.0005
0.0005- 0.0006
0.01
0.002 - 0.05
0.007 0.004- 0.01
0.04 0.003 - 0.57
0.02 0.01 -0.02
0.0006 0.0005 - 0.005
0.0005
0.0005 - 0.0006
0.01 0.002 - 0.26
0.003
0.003 - 0.005
0.07
0.02 - 0.22
0.06
0.04 - 0.08
0.0005
0.0005 - 0.005
\
0.0005 0.0005 - 0.0005
-0.01
0.002 0.04
0.008 0.006 - 0.01
0.03
0.008- 0.09
0.03
0.02- 0.03
0.11
0.008- 0.38
0.05
0.02- 0.12
0.03
0.007 - 0.15
0.02 0.01 -0.03
0.0006 0.0005 - 0.002
0.0005
0.0005 - 0.0006
0.0006 0.0005 - 0.001
0.0005
0.0005 - O.OO0
0.0005
0.0005
0.0005- 0.0006 0.0005 - 0.000
0.0005 0.002- 0.02
0.004
0.003 - 0.006
0.02 0.002 - 0.007
0.009
0.004 - 0.02
0.005
0.002- 0.02
0.003
0.002- 0.005
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TABLE 8
3M Company
Page 26 of 36
Year 2000 Antwerp Fluorochemical Medical Surveillance Program
Arithmetic Mean, Range, Geometric Mean and 95% Confidence Intervals of Serum Fluorochemical Levels (ppm)
For Employees who Self-reported> 50% and 30% - 50%Time in Building 3 Production Areas
PFOS Arithmetic Mean Range
Geometric Mean 95% C.I.
PFOA Arithmetic Mean Range
Geometric Mean 95% C.I.
PFHS Arithmetic Mean Range
Geometric Mean 95% C.I.
PFOSAA Arithmetic Mean Range
Geometric Mean 95% C.I.
M570 Arithmetic Mean Range
Geometric Mean 95% C.I.
b= FC Alcohol
> 50%
30% - 50%
18
N = 14
2.37
0.25 - 6.24
1.94 1.37-2.75
1.71
0.40 - 4.86
1.47
1.07- 2.03
1.89
0.15 - 3.59
1.56
1.07- 2.27
1.54
0.79 - 3.33
1.46
1.20- 1.76
0.47
0.03 - 1.37
0.36
0.23 - 0.55
0.29
0.03 - 0.97
0.20 0.12-0.34
0.05
0.006 - 0.12
0.04
0.03 - 0.06
0.04 0.02 - 0.06
0.04
0.03 - 0.04
0.51
0.03 - 1.06
0.43
0.30 - 0.62
0.44
0.18 - 0.67
0.42 0.35 -0.51
Intemal Chemical
> 50%
30% - 50%
N = 11
N = 13
1.86
1.13 - 3.25
1.73 1.37 -2.19
1S O
0.25 - 4.86
1.16
0.76 - 1.77
1.50 0.97- 1.90
1.47
1.29- 1.68
1.28
0.15 - 3.33 1.oo
0.63 - 1.59
0.38
0.08 - 0.74
0.31
0.20 - 0.49
0.26
0.03 - 0.97
0.17
0.10 - 0.29
0.04
0.02 - 0.06
0.04
0.03 - 0.05
0.03 0.006 - 0.05
0.03
0.02 - 0.04
0.43 0.18-0.59
0.41
0.37 - 0.50
0.39
0.03 - 0.58
0.32
0.20 - 0.51
- Flaker
> 50%
30% 50%
N=2
N=5
Ground Floor Dnunming
> 50%
30% - 50%
N=6
N = 10
1.96
1.64 - 2.27
1.93
1.40- 7.21
1.55
0.65 - 2.26
1.44
0.95 - 2.98
-1.28
0.44 2.46
1.07
0.62 - 1.24
1.25
0.72 - 1.72
1.22 1.03- 1.82
1.58
1.51- 1.66
1.58
1.43 - 1.74
1.58
1.18 - 2.24
1.54 1.23 - 1.93
1.23
0.42 - 1.64
1.13
0.75 - 1.70
1.39 1.08- 1.64
1.38 1.24- 1.53
0.42 0.42 -'0.43
0.42
0.42 - 0.43
0.24 0.11 -0.50
0.21 0.13 -0.34
0.26
0.04 - 0.52
0.19
0.08 - 0.42
0.21 0.08 - 0.36
0.19 0.13 -0.26
0.03
0.03 - 0.03
0.03
0.02 - 0.04
0.05
0.03 - 0.07
0.04
0.03 - 0.07
0.03
0.003 - 0.06
0.02
0.01 - 0.06
0.04 0.02 - 0.07
0.04
0.03 - 0.05
0.44 0.32 -,0.56
0.42
0.24 - 0.75
0.55
0.40 - 0.76
0.53
0.41 - 0.69
0.33
0.02 - 0.52
0.21
0.07 - 0.62
0.46
0.36 - 0.76
0.45
0.39 - 0.52
Fluorel
> 50%
30%-b'%%
N=3
N=3
0.54 0.37 - 0.71
0.52
0.36 - 0.76
1.18
0.52 - 2.32
0.94
0.38 - 2.36
0.56
0.16 - 1.21
0.40
0.12 - 1.30
0.50
0.05 - 1.03
0.29
0.05 - 1.62
0.10 0.04 -0.15
0.09 0.04 -0.19
0.17
0.01 - 0.48
0.06
0.007 - 0.50
0.02 0.006 - 0.04
0.02
0.006 - 0.06
0.06
0.003 - 0.14
0.02
0.002- 0.21
0.07 0.03 -0.10
0.06 0.03 - 0.12
0.07
0.02 - 0.14
0.06 0.02-0.18
Table 8 (continued)
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Page 27 of 36
PFOSA Ariihmetic Mean Range
Geometric Mean 95% C.I.
M556 Arithmetic Mean me
Geometric Mean 95% C.I.
0.003 , 0.0005-0.007
0.003
0 . h - 0.004
0.15
0.006 - 0.48
0.12 0.08-0.18
0.003 0.0005-0.006
0.002
0.002 - 0.003
0.10
0.04 - 0.16
0.10
0.08 - 0.12
0.002 0.001-0.003
0.002
0.002 - 0,003
0.11
0.04 - 0.18
0.10
0.07 - 0.14
0.002 0.0005-0.006
0.002
0.001 - 0.003
0.09 0.006-0.16
0.07
0.04 - 0.1 1
0.002 0.002-0.003
0.002
0.001 - 0.004
0.003 0.001-0.004
0.002
0,001 - 0.003
0.002 0.0005-0.004
0.001
0.0007 - 0.003
0.002 0.0005-0.006
0.002
0.001 - O.OO3
0.11 0.08-0.14
0.10 0.006-0.19
0.15 0.08-0.21
0.14 0.10-0.20
0.07 0.002-0.13
0.04 0.01 -0.14
0.09 0.006-0.17
0.09
0.07 - 0.12
0.001 0.0005-0.002
0.0008
0.0002 - 0.002
0.002 0.0005-0.09
-0.001
0.0002 0.00
0.01 0.006-0.02
0.01
0.006 - 0.03
0.002 0.002-0.05
0.01
0.002 - 0.06
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TABLE 9
3M Company
Page 28 of 36
Year 2000 Antwerp FluorochemicalMedical SurveillanceProgram ArithmeticMean, Range, GeometricMean and 95% Confdence Intervalsof Serum FluorochemicalLevels (ppm)
for Building 16WorkersWho Were Shift OperatorsWorking in the Glass Unit
?
PFOS Arithmetic Mean Range
Geometric Mean 95% C.I. PFOA Arithmetic Mean Range
Geometric Mean 95% C.I. PFHS Arithmetic Mean Range
Geometric Mean 95% C.I. PFOSAA Arithmetic Mean Range
Geometric Mean
95% c.1.
Shift Operator Sometimes (soms)
N = 11
0.42
0.21 - 0.9
0.39 0.30 - 0.49
2.18
0.10 - 4.03
1.65 0.88 - 3.07
0.17
0.03 - 0.50
0.10
0.05 - 0.19
0.003
0.003 - 0.003
0.003
0.003 - 0.003
Shift Operator Often (vaak)
N=5
0.61 0.44 - 0.78
0.59
0.46 - 0.76
4.71 2.42 - 7.04
4.42
3.06 - 6.39
0.53
0.04 - 0.71
0.38 0.13 - 1.11
0.003 0.003 - 0.003
0.003 0.003 - 0.003
Day Operator Sometimes (soms)
N=O
-
-
-
-
-
Day Operator Often (vaak)
N=3
0.82 0.45 - 1.37
0.73 0.38 - 1.42
2.64 0.78 - 4.19
2.13 0.76 - 5.95
0.36 0.25 - 0.45
0.35 0.25 - 0.50
0.04 0.003 - 0.11
0.01 0.0009 - 0.11
M570 Arithmetic Mean
Range
f
Geometric Mean
95% C.I.
PFOSA Arithmetic Mean Range
Geometric Mean
95% C.I.
M556 Arithmetic Mean Riwe
Geometric Mean
95% C.I.
TABLE 9 (continued)
BACK TO MAIN
3M Company Page 29 of 36
0.02
0.01 - 0.03
0.02
0.02- 0.02
0.0005
0.0005 - 0.005
0.0005 0.0005 - 0.0005
0.03
0.002 - 0.01
0,003
0.002 - 0.004
0.02
0.02 - 0.03
0.02 0.02 - 0.03
0.0005 0.0005 - 0.0005
0.0005
0.0005- 0.0005
0.001 0.002 - 0.04
0.005
0.001 - 0.01
0.10 0.01 -0.26
0.04
0.006 - 0.28
0.0008 0.0005 - 0.001
0.0007 0.0004 - 0.001
0.02 0.002 - 0.05
0.008 0.001 - 0.05
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TABLE 10
3M Company
Page 30 of 36
Year 2000 Antwerp FluorochemicalMedical SurveillanceProgram Serum FluorochemicalLevels (ppm) by Frequency of Self-reported Laundered Clothes Among Building3 and Building 16 Operators, Fluorel Operatorsand Waste Treatment Operators (N= 88)
PFOS Arithmetic Mean Range
Geometric Mean 95% C.I.
PFOA Arithmetic Mean Range
Geometric Mean 95% C.I.
PFHS Arithmetic Mean Range
Geometric Mean 95% C.I.
Daily (Dagelijks)
N = 18
0.84 0.21 - 2.46
0.64
0.45 - 0.91
1.85 0.10 - 4.19
1.32 0.81 -2.14
0.33
0.03 - 0.90
0.20
0.11 - 0.36
Several Times Per Week
(Verschillende keren) N=53
1.48
0.16 - 6.24
1.10
0.88 - 1.37
1.86
0.06 - 7.04
1.51 1.24 - 1.84
0.30 0.01 - 1.37
0.18
0.14 - 0.25
Weekly (Wekelijks)
N = 13
0.89
0.31 - 2.28
0.71
0.49 - 1.04
1.26 0.42 - 4.03
1.oo
0.69 - 1.46
0.15
0.02 - 0.48
0.09
0.05 - 0.16
Every Two Weeks
(Omde twee weken)
N=4
1.39 0.90 - 1.92
1.31 0.87 - 1.97
1.83 1.20- 3.27
1.68
1.06 - 2.66
0.33 0.09 - 0.52
0.27 0.12 - 0.59
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TABLE 11
3M Company
Page 31 of 36
Year 2000 Antwerp FluorochemicalMedical SurveillanceProgram Serum FluorochemicalLevels (ppm) by Self-reported Frequency of Shower Activity After Work Among Building 3 and Building 16 Operators, Fluorel Operatorsand Waste Treatment Operators(N= 88)
\
Daily
Most of the Time
Sometimes
Never
@agelijks)
(Meestal)
(Soms)
(Nooit)
N=3
N=9
N=23
N =53
PFOS Arithmetic Mean Range
Geometric Mean 95% C.I.
PFOA Arithmetic Mean Range
Geometric Mean 95% C.I.
PFHS Arithmetic Mean Range
Geometric Mean 95% C.I.
1.42 0.95 - 2.28
1.30 0.75 - 2.28
1.19 1.14- 1.24
1.19 1.14- 1.25
0.13
0.09 - 0.20
0.13
0.08 - 0.20
1.68 0.39 - 6.24
1.04 0.53 - 2.02
1.77 0.45 -4.19 '
1.40 0.82 - 2.29
0.37
0.03 - 1.37
0.18
0.07 - 0.45
0.96 0.31 - 3.25
0.75
0.56 - 1.00
2.44
0.50 - 7.04
1.96
1.47 - 2.61
0.27
0.03 - 0.90
0.16
0.10 - 0.26
1.32
0.16 - 3.79
0.99 0.79 - 1.24
1.50 0.05 - 3.65
1.21 0.97 - 1.51
0.29 0.01 - 0.82
0.18 0.13 - 0.24
APPENDIX A
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Page 33 of 36
DEEL I (Part I): ALGEMENTE WERKACHTERGROND/INFORMATIE(Present
Information)
1. Hoe lang werkt u reeds bij 3M? (How long have you already worked at 3M?)
Aantal jaar (number of years): Datum van indiensttreding: (when did you start working):
2. Hoe regelmatig ververst u uw werkkledij? (How frequently do you wear fieshly laundered clothes?)
A. Dagelijks (daily) B. Verschillende keren per week (several times per week) C . Wekelijks (weekly) D. Om de twee weken (every two weeks) E. Andere (other)
3 . Hoe regelmatig neemt u, op het werk, een douche na de dagtaak? (How frequently do you take at work a shower after work?)
A. Nooit (never) B. Soms (eerder uitzondering) sometimes (rather as an exception) C. Meestal (eerder bij uitzondering niet) most of the time (rather as an exception not) D. Altijd (dagelijks) always (daily)
4. HeeR u ooit langer dan 2 weken gewerkt in de volgende afdelingen? Meerdere
antwoorden mogelijk. (Have you ever worked longer than 2 weeks in the following
departments? Mark all that apply.)
(How many yrs?) Last year?
A. Gebouw 02 magazijn (Bldg 2 warehouse)
Hoeveel jaar?
Laatste jaar?
B. Gebouw 03 oud gedeelte (Bldg 3 old section)
II
tl
C. Gebouw 03 nieuw gedeelte (Bldg 3 new section)
II
II
D. Fluorel (Fluorel)
II
II
E. Onderhoudsafdeling (Maintenance)
11
II
F. Administratie (Administration)
It
11
G. Laboratorium QA (QA Laboratory)
II
It
H. Laboratorium R&D (R&D Laboratory)
II
II
I. Gebouw 16 (Bldg 16)
II
II
J. fialwaterbehandeling (wastewater)
II
If
K. Andere (Other)
11
II
i
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3M Company Page 34 of 36
5. Wat is uw normaal werkschema (binnen uw huidige fbnctie)? [What is your normal workweek (within your current function)?]
A. 4-ploegensysteem (4 shift system) B. Dagdienst (days only) C. Relief (relief) D. QA 5-ploegensysteem (QA 5 shift system) E. Andere (Other)
DEEL I1 (part 11): HUIDIGE FUNCTIE (Current Function)
6 . In welke afdeling werkt u momenteel? (In which department do you work now?)
A. Gebouw 02 magazijn (Bldg 2 warehouse) B. Gebouw 03 oud gedeelte (Bldg 3 old section) C. Gebouw 03 nieuw gedeelte (Bldg 3 new section) D. Fluorel (Dyneon) (Fluorel, Dyneon) E. Onderhoudsafdeling (Maintenance) F. Administratie (Administration) G. Laboratorium QA (QA Laboratory) H. Laboratorium R&D (R&D Laboratory) ' I. Gebouw 16 (Bldg 16) J. Afbalwaterbehandelingwastewater) K. Andere (Other)
7. Welke is uw huidige knctie of welke omschrijving geeft best uw huidige knctie weer? (What is your peresent job and which description best fits your present job?)
- A. Administratie - proces ingenieur (Administration - process engineer)
B. Administratie (niet proces ingenieur) (Administration not process engineer) C. Laborant QC/QA (QNQC Laboratory worker) D. Laboratorium R&D @&D Laboratory) E. Gebouw 03 operator (incl. Chief) (Bldg 3 operator (including Chief) F. Fluorel operator (Fluorel operator) G. Gebouw 16 operator (Building 16 operator) H. f i a l w a t e r behandeling operator wastetreatment plant operator) I. Gebouw 02 magazijnier (Building 2 warehouseman) J. Gebouw 02 inpak operator (Building 2 package operator) K. Supervisie (Supervisor) L. Management (Management) M. Mekaqicien (Mechanic) N. Electficien (Electrician) 0. Boiler operator (Boiler operator) P. Andere (Other)
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8. In welk jaar startte u in deze fbnctie? (In which year did you begin this current work?) Hoelang werkt u reeds in deze huidige fimctie? (How long have you already worked in
this function?)
9. Indien u in uw huidige job in Gebouw 03 werkt, gelieve aan te duiden hoeveel van uw tijd u (naar schatting) met volgende uitrusting werkt? (If you are presently working in Building 3, please indicate how much of your time is dedicated to working with the fo1lowing equipment?)
A. FC alcohoVmonomer >50%
B. Internal chemicals
It
C. Flaker
I1
D. Gelijkvloerddrumactiviteiten
(Ground floor drumming)
E. Supervisie activiteiten
(Supervisory activities)
II
F. Chief-activiteiten
(Chief activities)
II
G. Fluorel
II
~O-SOYO
It
II
<30%
II
11
I1
It
It
0
11
11
II
niet (none)
I1 II II
It II
10. Indien u in uw huidgie job in Gebouw 16 werkt, in welke mate werkt u dan met de glazen unit? (If you are presently working in Building 16, to what extent are you working in the glass unit?)
A. Niet (none)
B. Als shiftoperator: soms (as shift operator: sometimes) C. Als shiftoperator: vaak (as shift operator: often)
D. Als dagoperator: soms (as day operator: sometimes)
E. Als dagoperator: vaak (as day operator: often)
DEEL III (Part Ill): FUNCTIEDIE U HET LANGST HEEFT UITGEOEEEND
(Function that you have worked the longest)
11. In welke afdeling heeR u het langst gewerkt? (In which department have you worked
the longest?)
A. Gebouw 02 magazijn (Bldg 2 warehouse) B. Gebouw 03 oud gedeelte (Bldg 3 old section) C. Gebouw 03 nieuw gedeelte (Bldg 3 new section) D. Fluorel (Dyneon) (Fluorel, Dyneon) E. Onderhoudsafdeling (Maintenance) F. Administratie (Administration) G. Laboratorium QA (QA Laboratory) H. Labordtorium R&D (R&D Laboratory) I. Gebouw 16(Bldg 16) J. Afvalwaterbehandeling (Wastewater) K. Andere (Other)
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3M Company Page 36 of 36
12. In welk jaar startte u in de fbnctie waarin u het langst gewerkt heeft? (In which year did you start the function in which you have worked the longest?) Hoelang heeft u in deze fbnctie gewerkt? (How have you worked in this fbnction?)
13. Wat was uw normaal werkschema in deze fbnctie? (What was your normal work week in this finction?)
A. 4-ploegenstysteem (4 shift system) B. Dagdienst (days only) C. Relief (relief) D. QA 5-ploegensysteem (QA 5 shift system) E. Andere (Other)
