Document QX7KdVwqvdNrNGZjnN56DmnX6

Knowledge Web(r) Document Display Page 1 of 2 Shon hC\t Include in selection list. --Document # 1of 57 from MEDLINE Relevance to Query: Maximum Relevance: Epidemiology of the non-Hodgkin's lymphomas: distributions of the major subtypes differ by geographic locations. Non-Hodgkin's Lymphoma Classification Project. Ann Oncoll998 Ju1;9(7):717-20 (ISSN: 0923-7534) Anderson JR; Armitage JO; Weisenburger DD [Find other articles w&h these Authors] Department of Preventive and Societal Medicine, University of Nebraska Medical Center, Omaha, USA. BACKGROUND: There has been no previous systematic study of the distribution of the major subtypes of non-Hodgkin's lymphoma (NHL) across geographic regions, although there have been isolated reports of such differences. DESIGN: As part of a clinical evaluation of the International Lymphoma Study Group (ILSG) classificationof NHL, we classified 1378NHLs from eight different geographic sites (Omaha, NE, USA; Vancouver, BC, Canada; Capetown, South Africa; London, England; Wurzburg/Gottingen, Germany; Lyon, France; Locarno/Bellinzona, Switzerland; and Hong Kong) using the ILSG classification. RESULTS: Substantial differences were found in the distributionof the major subtypes of NHL across geographic regions (P < 0.0001). A greater percentage of follicular lymphoma was seen in North America, London and Capetown (3 1% versus 14% at other sites). Peripheral T-cell lymphoma was more common in London, Capetown and Hong Kong (9%) than elsewhere (3%). In Locarno/Bellinzona, higher percentages of mediastinal large Bcell lymphoma (go/,versus 2% elsewhere) and mantle cell lymphoma (14% versus 6% elsewhere) were seen. Angiocentric nasal T-/NK-cell lymphoma was only seen in Hong Kong (8%) and Lyon (2%). CONCLUSIONS: Our study provides evidence that the distribution of NHL subtypes differs by geographic region. These findings suggest that geographical differences in etiologic or host factors may be responsible for the observed differences in the distributionof cases across NHL subtypes. Major Subject Heading(s) 0 Lymphoma, Find other articles will1 similar Subjects. Minor Subject Heading(s) 0 Hong Kong [epidemiology] Lymphoma, Non-Hodgkin [classification- 0 South Africa [epidemiology] 0 Switzerland [epidemiology] 0 United States [epidemiology] Indexing Check Tags: Human; Support, Non-U.S. Gov't; Support, U.S. Gov't, P.H.S. Language: English Unique NLM Identifier: 98411753 MEDLINE Indexing Date: 199901 Publication Type: JOURNAL ARTICLE 1 htt.../getdoc.cgi?listord=l &searchid=2&have-local-holdings-file=O&localjournals-only= 10/13/1999 Knowledge Web(r) Document Display Grant ID: CA 36727-CA-NCI Page 2 of 2 ~~ ' C o ~ ~ s S y s t e l n s C o r p o r a t i o2n00,Sutton Street, North Andover, MA 01845 USA. (978) 9757570. All Rights Reserved. Knowledge Finder@,Knowledge Server@,Knowledge Host@,Knowledge Web@,and Enhancing the Power of Knowledge0 are all registeredtrademarks of Aries Systems Corporation. htt.../getdoc.cgi?listord=l&searchid=2&have-local-holdings-file=O&locdjournals-only= 1011311999