Document QX4RGxBeb5jKNmzRp1L1Dyz0R

PFOS 3M FLUOROCHEMICAL SUBMISSIONS February, 2002 - May, 2004 TOXICOLOGY, EPIDEMIOLOGY AND MEDICAL SURVEILLANCE Click on Study Title to View Report Perfluorooctanesulfonate PAGE 1, 2 Summary Environmental and Health Assessment of Perfluorooctane Sulfonic Acid and Its Salts, 3M, August 20, 2003. [SubmittedAugust 25, 2003] APPENDIX I: Robust Summaries for Physical/Chemical Properties and Environmental Fate Studies APPENDIX II: Robust Summaries for Ecotoxicological Studies and PNECs APPENDIX III: Robust Summaries for Toxicological and Human Health Studies APPENDIX IV: Benchmark Dose and Benchmark Internal Concentration Calculations Repeated-Dose Toxicity 1. Benchmark Doses for Liver Tumors in Sprague Dawley Rats fed Perfluorooctanesulfonic Acid Postassium Salt (PFOS), January 24, 2002. [SubmittedMarch 13, 2002] 2. Final Report, Extended Recovery Study Following a 26-week Capsule Toxicity Study with Perfluorooctane Sulfonic Acid Potassium Salt (PFOS; T-6295) in Cynomologous Monkeys, December 4, 2001, Covance Laboratories, Inc. [Submitted July 16, 2002] 3. Final Report, Analytical Laboratory Report, Determination of the Presence and Concentration of PFOS in Serum and Liver samples of Cynomologus Monkeys, May 3, 2002, 3M Environmental Laboratory and Pace Analytical Services, Inc., Study T-6295.22. [Submitted July 16, 2002] 4. 4-Week Capsule Toxicity Study with Perfluorooctane Sulfonic Acid Potassium Salt (PFOS; T-6295) in Cynomolgus Monkeys, Covance Study No. 6329-222, 3M Reference No. T-6295.6, April 9, 2002. [Submitted July 9, 2003] Pharmacokinetic Study 1. A Pharmacokinetic Study of Potassium Perfluoroocatanesulfonate in the Cynomolgus Monkey, Southern Research Institute Study ID 9921.6, 3M Reference No. T-6295, April 22, 2003. [Submitted July 9, 2003] 2. Final Report, An Investigation of the Mechanism of Toxicity in Adult Rats Exposed to High Levels of Perfluorooctanesulfonate (PFOS), 3M Project No. T-6295.31, April 23, 2004. [SubmittedMay 11, 2004] 3. Final Report, Analysis of Liver Enzymes, Glycogen, and Perfluorooctane Sulfonate (PFOS) Concentration in Samples from T-6295.25: One-Generation Reproduction Study of PFOS - Mevalonic Acid/Cholesterol Challenge and NOEL Investigation in Rats, 3M Project No. T-6295.28, April 23, 2004. [SubmittedMay 11, 2004] 4. Letter Report, Determination of Possible Interference of Perfluorooctane Sulfonic Acid Potassium Salt with Assay for Rat Cholesterol, 3M Project No. 6329.263, August 17, 1999. [SubmittedMay 11, 2004] PFOS TOXICOLOGY, EPIDEMIOLOGY AND MEDICAL SURVEILLANCE Click on Study Title to View Report Back to Menu Perfluorooctanesulfonate PAGE 1, 2 Reproductive 1. Final Report, Oxygen Saturation and pO2 Levels in Rat Pups Borne to PFOS Exposed Dams, February 20, 2002, Study No. T-6295.30; ST69, 3M Strategic Toxicology Laboratory. [Submitted July 16, 2002] 2. One Generation Reproduction Study of PFOS - Mevalonic Acid/Cholesterol Challenge and NOEL Investigation in Rats, 3M Reference No. T-6295.25, December 16, 2002. [Submitted July 9, 2003] a. TSCA 8(E) Supplemental Submission: Docket No. 8EHQ-998-374 Perfluorooctane Sulfonate (PFOS) CAS # 2795-39-3: One Generation Reproduction Study of PFOS - Mevalonic Acid/ Cholesterol Challenge and NOEL Investigation in Rats Sponsor's Study Number: T-6295.25. [Submitted January 27, 2003]