Document QX3zMJOo4OJQQQx3ad2MRNDG6

/ COP Y - Dept. of Fnysics . The C o lle g 'o:f L i t e r a l A rts IORTffi^STBHI UNIVERSITY Evanston, I llin o is .ov. '3 , -1945. D r. Graham E dgar Eth y l Co rp o ratio n 405 L exington Avenue Hew Y ork, ii. Y- ' ' . B e a r, D r. Ed gar* I am -w ritin g you i n th e b e l i e f t h a t p o s s i b l y you m ig h t be i n a p o s i t i o n t o h e lp me, ev en th o u g h t h i s h e lp sh o u ld c o n s i s t m e re ly in p u t t i n g me in to u c h w ith one o r more p a r t i e s who m ight be i n t e r e s t e d in w hat I have to o ffe r , I am i n c h a rg e o f t h e L a b o ra to ry o f A p p lie d S p e c tro s c o p y a t N o rth w e s te rn U n i v e r s i t y . We have j u s t c o m p le te d a p r o j e c t f o r th e M ed ical D iv is io n o f th e . N atio n al Research Council d ealin g 7/ith th e q u a n tita tiv e sp ectro g rap h ic determ ination of antim ony In u rin e fo llo w in g dosages of antimony drags to p a tie n ts s u ffe rin g w ith f i l a r i a s i s . This p ro je c t te rm in ated O ctober 31. A f te r December 1 I am b e - b e ' e m p lo y e d -h a L f-iim e as. s p e c t r a s e o p i s t on a new re s e a rc h p r o je c t a t N o rth w e ste rn . I t seems t h a t I m ust depend la r g e ly upon mys e l f t o b r in g my e m p lo m e n t up t o a f u l l - t i m e b a s i s . I h av e an a s s i s t a n t who, i f n e c e s s a ry co u ld be depended on to do work on a f u l l o r p a r t- tim e b a s i s . - A lth o u g h we s h o u ld b e i n t e r e s t e d i n any e m is s io n o r a b s o r p tio n p ro b lem i n t h e u l t r a v i o l e t o r v i s i b l e ra n g e , we a r e p re p a re d t o go i n t o p ro d u c tio n im m ed iately on a problem such as th e q u a n tita tiv e d eterm in atio n o f m etals in b io lo g ic a l flu id s o r tissu es. There a re two ty p e s o f problem s, d e a lin g w ith le a d in to x ic a tio n t o w hich I have g iv e n some th o u g h t. I know t h a t a g r e a t d e a l h as been done on le a d i n t o x i c a t i o n , a t th e U n iv ersity , of M ichigan, a t th e K e tte rin g Laboratory/ of A pplied Physiology o f th e U n i v e r s i t y o f C i n c i n n a t i , and many p la c e s e ls e w h e r e . H ow ever, I b e l ie v e t h a t my la b o ra to ry could c o n trib u te , perhaps, som ething of value in th is f ie ld by reason of th e f a c t th a t p u r procedure and technique in th e p re p a ra tio n of samples is d iffe re n t from t h a t o f o t h e r i n v e s t i g a t o r s . Our minimum re q u ire m e n t o f u r in e p e r sp ectru m i s o n ly ml,, a lth o u g h we l i k e t o r e c e iv e 2 o r 3 m l. M o reo v er, we do n o t a s h th e u rin e, sam ples, b u t mix w ith i t an eq u al amount o f a b u ffe r s o lu tio n c o n ta in in g th e in te r n a l standard O ne-half ml of the. m ixture is e v a p o ra te d .d ir e c tly in to th e c a v ity of a g ra p h ite e le c tro d e and t h i s e le c tro d e is arced in ta k in g th e spectrum . The e v a p o ra to r we u se i s u n iq u e and I th in k a d e s c r ip tio n o f i t s c o n s tr u c tio n and m anner o f u s i s w o rth y o f p u b l i c a t i o n . Summing u p , I b e lie v e we c o u ld c o n trib u te .. Kk 0019641 f% so m eth in g t o t h e s u b j e c t o f l e a d i n t o x i c a t i o n f o r two re a s o n s : ( 1 ) we u s e o n ly a sm all amount of sam ple, making i t p o s sib le to sh ip by a i r n a i l a t low c o s t; and (2 ) our sample p re p a ra tio n is d ir e c t and sim p le, th u s red u cin g th e c o s t o f a n a ly s is . The two ty p e s o f problem s r e f e r r e d t o above a re o u tlin e d b r i e f l y below ; - 1 . A S tu dy o f Lead I n t o x i c a t i o n Ca u se d by I n d u s t r i a l O c c u p a tio n s . The s tu d y of t h i s problem, w ould lo g ic a lly le a d to th e developm ent o f a r a p id , low c o st method o f t e s t i n g u r i n e s a m p le s , a t 'i*egu3,a r i n t e r v a l s , fro m p e rs o n s e x p o se d t o th e d a n g e rs of lead in to x icatio n by reason of th e ir occupation. 2 A GEOGRAPHICAL STUDY o f t h e Le a d C o n te n t o f b r i n e . The o b v io u s re a s o n f o r t h i s study is to determ ine w hether th e modern environm ent to w hich most people are su b jected is re sp o n sib le fo r th e accum ulation of an>excess amount of le ad in: t h e i r system s." I know t h a t some work h a s b e e n done on e a c h o f t h e s e tw o p ro b le m s . H ow ever, f o r t h e re a s o n s s t a t e d a b o v e , I th o u g h t t h a t my la b o r a t o r y w ould be i n a p o s i t i o n to c o n trib u te som ething a d d itio n a l in connection w ith them . . I was a t th e U n iv e rs ity of V ir g in ia when you w ere on th e F a c u lty t h e r e . I h a d o n ly th e c o u rs e i n G en eral C h em istry u n d e r P r o f e s s o r B ir d . My i n t e r e s t i n s c ie n c e developed a f te r leav in g V irg in ia . I n my a tte m p t t o f i n d a s u i t a b l e r e s e a r c h p r o j e c t f o r my l a b o r a t o r y , any advice o r le ad s would be g re a tly a p p re c ia te d . Sincerely yours, S/V. H. A b b itt KET 0019642