Document QO8eqN38N2nqvL2907Dvbde4

3& PU./Z- CONFERENCE ON PHENIL MERCT7H5T OLEATE IN PAINTS - 2-20-56 Barnes, Williams, Zapp, and Hood present F&F has authorized the project for the determination of the mercury hazard in paints. Following work should be done: ORAL Phenyl mercury oleate as a .2% solution in linseed oil. Run controls on the linseed oil. SKIN ABSORPTION Decide on 1 to 2 cc for 5 and 10 treatments, two rabbits in each group. First run a pilot test for the two types of paint and try it at 2 cc. Save animals for JB. Plan work with JB so that it can be staggered according to the work load of both Chemistry and Toxicology. HUMAN PATCH TEST Problem - Do we want to run the risk of sensitizing subjects by running the ordinary patch test? I am against this. I would suggest that first I try a patch of the dry material for 2lj. hours. Since I am allergic to Merthiolate, it would be wise to see whether this can be brought out by the paint. If this is satisfactory, it might be worth trying a 2l4.-h.our test on approximately 20 subjects. DBH/rlm 11-23-56 DUP040001193