Document QMEyNZ3wamGKmdX3opBmkdOkE

4 #PDD E. I. du Po n t de N e m o u r s & Co m p a n y IN CO RPORAT EO W il m in g t o n . De l a w a r e 19898 POLYMER PRODUCTS DEPARTMENT EXPERIMENTAL STATION PERSONAL AND CONFIDENTIAL cc: A. J. Dahl B. W. Karrh L. J. Papa Pral File I.C. 1\ i - 353 - N11400 - 269 s4/ezzc,-/57 May 19, 1981 TO: DR. Y. L. POWER - PPD, Washington Works FROM: S. S. STAFFORD ANALYSIS OF BLOOD SAMPLES FOR PERFLUOROOCTANOATE (Job No. 810-190; PRAL Nos. 81-1488-1501; Notebook Nos. E22514.E26238) As requested in your letter of 4/14/81 to L. J. Papa, the 14 blood samples submitted then have been analyzed for perfluorooctanoate (Cg) . Results and sample identification are given in the attached table. As noted there, the analysis was done using a gas chromatographic method specific for Cg (Lab Method Number ES-567) but results have been reported as ppm F for comparison with total organic fluorine analyses. Precision is + 10% relative standard deviation over most of the concentration range, somewhat less at the lowest values. The lower limit for quantitation is 0.007 ppm F (0.01 ppm perfluorooctanoic acid), with a detection limit of a. 0.004 ppm which can be distinguished from the reagent background but not well quantitated. Please contact me (772-4440) or L. J. Papa (772-2745) if you have any questions regarding the analyses. General questions on blood sampling can be directed to J. W. Raines or L. F. Percival. Attachment jah Keywords : Perfluorooctanoic Acid Perfluorooctanoate Blood Analysis GC There's a world of things we're doinq something about 000077 EXP000009 E ID713823 4 'l 11 i TABLE I CONCENTRATION OF PERFLUOROOCTANOATE IN BLOOD (a) Sample PRAL No. Date Sampled 81-1488 81-1489 81-1490 81-1491 81-1492 81-1493 81-1494 81-1495 81-1496 81-1497 81-1498 81-1499 81-1500 81-1501 4/7/81 4/7/81 4/7/81 4/7/81 4/7/81 4/7/81 4/7/81 4/8/81 4/8/81 4/8/81 4/9/81 4/10/81 4/10/81 4/10/81 p .r .: ws ws ws 4227 WS 4466 4264 4432 4553 4151 4296 WS 4443 - Name GC Analysis____________________ (b) Date Analyzed [Ca], us F/g blood 4/22/81 4/22/81 4/22/81 4/22/81 4/23/81 4/22/81 4/23/81 4/23/81 4/23/81 4/23/81 4/15/81 4/15/81 4/15/81 4/15/81 0.53 0.23 0.41 0.062 0.94 0.048 0.45 0.59 3.5 1.3 2.5 0.28 0.070 0.055 (a) Apalysis as described in Lab Method ES-567 ("Determination of Perfluorooctanoic Acid in Blood, Gas Chromatographic Method", S. Stafford, 4/3/81), using the packed column GC analysis with perfluorc-n-octanoic acid as calibration standard. (b) Although the analysis is specifically for perfluorooctanoate (acid or salts), concentrations are given in ppm fluorine for comparison with the results of total organic fluorine analyses. (ppm F = 0.688 x ppm perfluorooctanoic acid) Estimated uncertainty is + 10% relative standard deviation. The lower limit for quantitation is 0.007 pgF/g. The detection limit is n, 0.004 ygF/g, but concentrations in that range cannot be well quantitated and are reported as < 0.007. None detected (n.d.) is reported for samples with [Cg] < 0.004 ppm, which cannot be distinguished from reagent background. REDACTED* EXPOOOOIO EID713824 000078