Document QM470Jwznx6LZ4Vpm5Yvnp8XE

ftl.MI* III lltii'kloy >/ ill. i IMoi'tl'Mi nf Mloornl Kllu'is | Tlssiio dp ml It* milii|illi-!llliin* ulul f-u lllirMiiMlI'ili of Mta M,i|iiglr.*l ell ml* Ilf lla NKUAI. Slum oil tile rnlliilur levei In aititlllim. tile illiiaoiist* of the (Milenlliil rule of lupins In a illsrasr (ii'in'ess usually (i|K-ml ii|kui . sill h (lemonsl ral Inn. < Mnlirinr, Y. ,V. J. f N.J. Iitilevd. the observation of these fillers is nniiiuely facilltalert by the fact thsl. as a result of tissue reaction, many of the fibers become coaled with an unusual iron-rich gel of characteriatic appearance and behavior. readily ricognlted, only infrequently mimicked, and, for practical purimses, pathog nomic for the preaencc of asbestos. At first termed "curious bodies" or "brown bodies" they were soon named "usbcstOMis bodies" by Stewart and Hsddow* and "asbestos bodies" by Gloyne." * It was the presence of these unusual, specific, coated fibers -- asbestos ii bodies -- that called attention to the nature of the first cases of asbestoeis. When Montague Murray' described the histological findings in the lungs .-per that make poa. h'romcK in virii for t fction of otherwise ` ulaten by electronic nf h man who died in 1900 after having worked 14 years in an asbestos textile plant, he commented on the preaence of these particles; although no illustration of them was recorded at that time, re-examination of the tissues of this original case by E. L. Middleton confirmed their presence.' Simi larly, Fahr published no illustrations of the "peculiar crystals" seen in the jrimcnUI studies in ;ier respiratory exjsy specimens, espe- lungs of a woman asbestos worker, reported by him in 1914,* but he re ferred to their appearance as similar to the crystals described by Murchand In 1906,' when the latter described the unusual histological findings in the lungs of a young man working in a dye factory and a woman, the wife of sslinfuctory. Vari|n with histological - bodies are also dei<c microscopy were he lion of me t an the ad- an oven-placer. Review of the illustrations in Marchand's paper, leaves no doubt that these were asbestos bodies. When the first "contemporary" ease of asbestosis was reported in 1924'.* the unusual bodies were also rediscovered, with Stuart McDonald"1 calling attention to them on pathological study of Cooke's case. Careful investiga tion by McDonald led him to believe that they were not of vegetable or animal origin although they were briefly so considered by Cooke. Gloyne clarified thsir nature when he dissolved the bodice in concentrated sulfuric ; seld,`d*mon*tretlng a minute asbestos fiber sf"tl^ MntrUjjore^Gloyne ummsrlxod the early studies on the identification of asbestos bodies.11.V ?' conflict of living. ^.U whs soon found that fibers might well be .present unaltered, simulte-;v~;.. y fh asbctiM)lar>c.- ^ esoiialy With the changed, coated, ^asbesUsi body. Bhualer^ reported extern tistrial use simul- "' lve fibrosis in a dog that lived In an asbeatM factory* with many asbestos relative resistance acids and alkalis. ; may gradually und uncertain. ... fibers present, but with no asbestos bodies. Experimental atudies soon showed that among various species, there was a different pulmonary pons* in the production of asbestos bodies." Thus, as with the dog. fibers 1m tissue'liu^ inesis of asbestosIs' f New York and by tt. 14ons not*only ln"the nuin^Fbf,MfeiM 'fibera and a8bpAtos fctdlee in dif* ... ferent eases but also marked variation in the percentage of each. - : t..A | . . . k , r* ' ' y-r mliKi-*?A m&?AlLM' :i*.rtve* SWsS frr;i?.W2 r. op ' ft? j*.-. . KW'.l m SlMi 6000 >v ' PRODUCED BY poph