Document QM3nEjyky5xzEd1qDJb1yqxv6

REVISED REPORT Copies to; E. I. du Font de Nemours and Company Haskell Laboratory for Toxicology and Industrial Medicine HASKELL LABORATORY REPORT NO. 721-78 AR226-2875 Procedure; The test material, as an aqueous solution, was administered by intragast a group of ten young adult ChR-CD male rats, five times a week for two weeks, at a r level of 3,400 nig/kg/day; an additional group of ten rats served as controls and wa distilled water. Five control and five test rats were sacrificed approximately twolast dose. The remaining five control and five test rats were sacrificed 14 days a dose. Results; Dose (mcr/Wdav) 3.400 No. of Doses 10 Mortality 0/10 Clini First Week: Second Week; Recovery Perio Pathologic Changes;** Gross and microscopic compound-related changes w the livers of rats examined on the last day of dosing. The mean absolute liver wei greater than that of the control group. The liver weight of test rats examined aft period was 36% great^/- than the control group. Histologically, liver hypertrophy w rats. These changes appeared to be reversible although not completely during the 1 period. Sompany Sanitized. Does not contain TSCA CB) Company Sa"'''-or no, ----^-------------.-..--.---- ^,-, ...,^. i f ^^^^^^^------1------ Swnmarv.i^^^^^^------was adininistered orally to young adult. ChR-CD male rats at a rep level of^^W^rog/kg/day for ten days over a two-week period. The compound-related effect was hypertrophy of the liver. The changes observed would be expected to be c reversible given a longer recovery period. ..---.. liver, kidneys, lungs, brain, adrenals, heart, spleen ,sterna^T5onenia,rrow;^eyes lower gastrointestinal tracts, epididymides, testes, thyroid, parathyroid, pancre lymph-Tiodes-and-trachea. ----- Reporl It, Date Issued; December 1, 1978 Date Revised: December 1978 Report by: Approved by; W^tth T"^ T. Q. Dilwo Technician ^.tIttcLu^ A. Michael K Chief, Acute Investig .Company Sanitized. Does -- ) wn - ) ] p {eTnn i-- 8 g 1 Haske Lus2o.ca1t.oy4soorneTodseicNoetmoopurssoadndTnbCuormtpraniyal Ne- dicion sta, Lsomicony serowr w. 52. EEE -w fell 1.0 ochercodes --- foSromteasttienngt erm toiortlsmcina ty SE Chemicals, Dyes & Pigasats Dept. Jackson Laboratory Chambers Works 5 3 fESrEarcUeAdEmoefE:Lin ne to cToth'aeLiacio"nnstieemdaoftear1i0aclyo,ouuarsetsSlsSaItdZ i Sewn" raining sCvoaAssnRpCeCSCDnnoecnmioabooettefsSsnetvWasicittnhaonsS+eeeferctcooemamrrloeeciodlsrdt1oo5ul:sld8ea5,ySoraLHot7ve.er3or:r8oc2fh7.s-333,,FA4bv0aS0enhmaeddaEiToaldteearcsSLaoor2kd0ebSreyaeHeLrodnIcctsAahgeueteic | ie Sacrificed 57 Ch Louch dow. cemtning four were' sacrificed after a Fou f the Tesintog Hehe 1-day recovery periods controls are sections fier th en doe Lod che | 3|] rseoruveofsS15cSooomiuSnnCetyraiuaslnldSt,vEa1GnsIt-IGnnhCt1uav0ba2ceieesndusTdvpieetdnhas4nicesoncLandcrgnoenahypcieeeotnmortnneenbo/soiciesonnmtpno1sg3o1fAi)8eh1s5T:8oec5Fno,t1Hrve1aaa0lrs0eavdSooarRtienEtSTahShAceeekerreLbdeFstcebonycdMsiSsSnChth.rAaeSsgaRhnsaRthrpircsoiolgrma.tasofbtTaot0veiocaSaeetor4o E5E||f S| ssoetrrhoveTMa5ua1nrt6coiovnyerisoslamac'seLtsacAntdE,evaSsnnacIucnt7t8uaaauirtmeeepdnvsvsacitietekohtnsicacceadtcrovnpprseeieoorrrcenaaeoatfavkleyo1sf3f1oL18o5:ih85To,"ouu3rva0ntASoasGbirnhtteielnsbatSSpheesuartchbbyBehfoioenrebrshagedkuneGemheBeechoennJfeoevoaeFteia10odnaHhkscrsoees+ SE| RcoEcomoy period" "rive Control rae ware sacrifice See Sha Coch dove aed he remsintos Five cotects wer Sarifired gf mr ene e g 4 CompanySasa.Does et one TSC Col -- ) ) ouonteed Sato vBo=.eoet wm800l Hrs Meeks catoed snd weopuwctoeed ssven, sained fan, dior, EY 100 Iacrinacion, proptration, ud with orn: itt Wheks B0adccus,Falruimopnesdl psroes,esv,iskcmoemtpeertiaodn vsicaetoeTdofrasce, scsines wo 10 40 hoa desks SHcacartiuseadcisodn,vewetakpneecstso,enhuamprend,possttauirneesd 1f0aace,wedlisnheerTeoni,. | Second Vek: Pioutraec!tironi, ahemtpre.,fuSes,aMededFacpOCauyree,bwretskoaostsso,nisessed Macon Portes: woos fabolonle Cumtens++es See depentts chators Roper Wo. 2790 | iIe$t e5RfnSriaoMneeSahhreae1earlTeidibonenfeenssSga1tTc1t3aoawsoripuietd:siydrsWoacteoeEpnsCTniatvaa05nl,oYttoeemncshiSeesistnes cvn,aiehe eaerat,lhTeeuo3 hbaBe neeshdeeabyn ti.tsoSenBvroererereTewingeht oss sek sere ontined 5'th Liver (uit81McotdMornechoocniengriseer,pheMeateoemtnisotope hate sont sos he che SaLpToeC eA {1bi ntL-- tr TTreennstsntem-- alsle sseerwveeddaanc4occoommmmoonnOccoonnSttrea.t egreovee fox toe 12,00 HA5on and ad mH1 4r0s, FEE o oT aaL mchesn sN tonmachidune,epdinctusdi, ceeoctc,ecoronsustwryaottnste--rAiRe-- reerin]e-- , el-- eet en clea chet oe tor he 3,08 fe dos sos sna he Mistletoe a a ---- -- :) 5. : Jean | we oe Donic iaiE k $i{ oFi fBi five Date lesued: March 16, 1979 ig Approved by:lltO o er e 3