Document QM27pjg88rE2J16p6K7xp46bk
AR226-2766
FOR DU FONT USE ONLY
E. I. du Font de Neaours and Company
Haskell Laboratory for Toxicology and Industrial Medicine Elkton Road, Newark, Delaware 19711
HASKELL LABORATORY REPORT MO. 565-81
Material Tested
Paskell No. 14,694
Other Codes
Octanolc acid, pentadecafluoro-
aoBonluo salt*
Study Initiated/Completed 6/25/81 - 8/14/81
CB&D Department
Haskell Laboratory
ACUTE ORAL TOXICm COMPARISON TEST IN RATS
Procedure; The test materials, as suspensions In corn oil, were administered
by Incragastric Intubation In single doses to 9 groups (10 per group) of young adult Crl:CD male rats. Three dose levels (30 rats) were used for each test oaterlal. The surviving rats were weighed and observed during a 14-day recovery period and then sacrificed.
Results:
Dose
(g/fcg)
Average Body W^ght (g)
Suspension
(Z)
Average Doge (mL)
Mortality Ratio
H-14,094
670
256
480
256
200
250
4.0
4.28
9/10
2.7
4.55
4/10
1.1
4.55
0/10
s.^a.o..-------^081
Company
Results: (Cont'd.)
Dose
(g/kg)
Average Body W^ght (g)
Suspension
(?)
Average Dose (aL)
Mortality Ratio
H-14.121
670
260
480
253
200
258
H-12,037
4.0
4.36
10/10
2.7
4.49
10/10
1.1
4.69
0/10
670
258
480
251
200
253
4.0
4.32
10/10
2.7
4.47
6/10
1.1
4.61
0/10
Clinical Signs;
H-14,094
Stained and/or ec perineal area and Height loss at all
levels tea fed. Stained face at 200 and 670 ing/kg.
Weakness at 480 and 670 ing/kg.
Chronodacryorrhea at 200 mg/kg.
All deaths occurred within 4 days after dosing.
H-14,121 H-12,037
Stained and/or uet perineal area,
loss at all levels tested.
Weakness at 480 and 670 og/kg Lethargy at 670 og/kg,
All deaths occurred within 4 days
stained face and
after dosing.
weight
Stained and/or wet perineal area,
loss at all levels tested.
Weakness at 480 and 670 mg/kg. Diarrhea at 480 og/kg. Alopecia at 200 ag/kg. All deaths occurred within 4 days
stained face and
after dosing.
weight
^fflBBMT
fiB--BiB--MC H-14,121) and ammonnium ^peerrfflluuoorrooooccttaannoace (H-12,037) were adoinisterea as single oral doses to young adult Crl:CD* male rats. H-14,121 produced more deaths at the middle level tested (480 mg/kg) ehan the other 2 test materials; however, overall the 3 test materials appear to have similar toxicities. The 3 test materials produced similar clinical signs and
all deaths occurred within 4 days after dosing.
Cf^f
-.i1iU3.?'2-
-t)ir,--"-'-f;
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H-14.094
Synonyms:
MB Purity;! I
CAS Registry Number:
H-12,037
-6 AoBmmooQQiluuma iperfluorooctanoace o C-8
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SU,d.D..s"o,c.n<a,nTSCACa
Company
^P0" bvi
//L.^ A.^^ Llo\ni^H^inck^le
technician
Reviewed by:
Study Director
Approved by:
Chief, Acuce Investigations /Section
LH:jrg:WP:1.8 ,Dace Issued: September ^g, 1981 Ll sport Mb. 565-81
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