Document QLDpavv8eQ3zeybnjD5BRkD7

9H0a5rsShhae,ehPyArnd A Telephone: (215) 4438710 Tefoc 215) 4439567 ARQaE_ 112% 5 - ARGU; S RESEARCH Charles River Laboratories Discovery and Development Services September 11,2002 J3oMhnCoBruptoernahotfefT,oPxhi.cDo.l,ogDyAB, CTH 3M Medical Department S3t.MCPeanult,erM,inBnueilsdoitnag 5252104-42-E1-00020 NES ECEIVE (| SEP 1 220 Telephone: (651) 733-1962 Telefax: (651) 733-1773 RE: Protocol 418-020 - Oral (Gavage) Reproduction STtwuod-yGoefneArmamtioonni(uOmnePeLriftlteuropreorocGteanneoraattei(oAn)PFO) in Rats Sponsor's Study Number: T-6889.6 Dear Dr. Butenhoff: you Enclosed requested. are the copies of the estrous cyele evaluation forP and F1 generation rats which If you have any questions, please do not hesitate to contact me. Sincerely, 7(useSnageo-- Jo Ann Frazee, M.S, Study Coordinator z. 8oN2 Enc. @a3 000003 002947 ESTROUS CYCLE EVALUATION P GENERATION FEMALE RATS 000004 | EJXB AiCniTonCOPY J 00947, ros 18020 DOSAGE: Argus [eo"ARTICLE/SUBSTANCE: laPFO (GENERATION: |ROUTE: [TYPE OF TEST: [Estrous Cycle Evaluation [SPECIES/STRAIN: P= proestrus -- -- =Estrus M=Metestrus 0 =Diestrus zfs elstetrislolw]lmlullul ate[oeTakefoo [ve[3 [or py [77we Ey [ase|adc[OC x [5 [75 [5% [ey cranevermrme] 20 [155 [i200[18 [aos [ier| 5m | ad| gn = pa [P= ap|mos uss [> EEEhf Ee[7 oe oe [30[1] eti TechTime Start 1[13A | E2Y Euleor 0 hil i dre ol | El eT) R e i 5 |dno l i200FLucl EE =a EEu oY [oer [ov[ffm [o[PlE[PTIm[l ADv] [oz >[>[pF [nfo [e[E[DeInTeld[OP] [wee Tw[DpTeTm[dP] pv?[2 [D[0] [wee Je [EE[MXEWE[lm e I[ MmTpp[[ D [t | [or [ v[Ep|[*[eln[dle [EM[DP] [ooo TelololelzI9[D[PDliee[lmju]| [wo [elope [mlolelelnlolee[O[D10] [wen [>le@en[D [vo elelm(d[oleln[]0p] Lue [elc@p[ple[Elo[lDlDolIoD]Ob] RoviewedBy: m. Maids: Date: ~(50/ ifn Olden 1350-133%133 reaodu ALC Sddanas - ave fed Rone ecaoiosr a A! Got oto Geen wG re = TE 0000055 TotesPP! EBkElNe GnGasBphosnlwro citen Bas ie EXJFAsCTeCOPY ] 002948 _ Argus i Ee eee 118-020 |APFO |Estrous Cycle Evaluation rS 0 (venniace) Pp Jorai(Gavage) [Ratci:c0 (sD) 163BRVAFPUSE.| ves IT I T[YlelsTE [alsElZsP]PrEl2o8ElSolml[nElPmRnElPnR lmu] [hwomoensJ|e|m[B|10[el|m[D|0[[ e[m[ p]| ?[ZTA] [[CCoeses Ife>I[pm[n0[[2P[mlloelel[eez([zmrm[niep0b[[lD1Ie2O]] CCaoeers [[>mWpe[[m2l[omllee[leDmeoolne[[7e1m2[DOOD]] [CTasmee TTooTsoof[eT[oelTom[oe[e2[[oImPIb[Ih2[Im[[ODnO]] [[CCouem JlPe[[e>c [lomppllelleo[[mDIePleelfdF [[mDleeT[oe[[2A]] C[oCeone JJec[MWoD[150a[e2[wm[[oDpTl[ez[[mnb[DbIeDI[~A1DD|] [[CCooems JweIebLIneggliisse[[7m[20[lo0[1S[[ZmPdlrml12o[[D0]] [Ceomr JJee[[oesm[[0Dellpalleol[[bcol [ImBDIe ID0p[l 2IO[e P0]| CCooe JJeo[ee[wMv[bD[leellee[mmoollpellee[[MMIISO]]D]e]] [ow Je[oop]eclofoolblloe[l=ae] ------ NF +--t--t+--t+--+--F+--F+------------ Bese, BENGE Reviewed By: nm NaH, ` Date: Rs 1501 000006 (BR) J JF alex 0029439 ER Argus fla18-020 |APFO |Estrous le Evaluation | wo Jp lowiGavage) [Ral(SDC)IrGSB:RVCAF/DPluse | P =Proestrus - =snus M=Metestnus 0 =Diss [o[ atT s a Trtoz terailftsorl[iae[]vsseflaea [[er7stfsas[tTousfftooof)ao]rlraof13or]o1ne]| manors | [1TTTT T [ T [ T [ T | [me Je[dP ollmpero[elm[D[o[]D2] [ress In [ele mol?PPem[o]e[en[DP] [es [ess | wer [oss [oe [eo [ea I[nppfeefD e [I SIDD ITN[[F eDnPF [[DI eIRE PTI T[eFOl--m OF>]-- J[Pep [JeE>DI[SSTp[[EEImm[Db[[[PPm]ee[[[MDn[mlOle]o[[[[DZEc]| [[[wETeeellm ee[[mmD Ddlplelo leel llre e[m[[nec]d[[m[ dl[lo eeM[]O]D]Dc2e]]] [eee [eo [e[MID[PlE[ [6mDp [oflc[e 7] [mes [mee [ femJoe[e>[[>D[oele o [p ee [me[IDMm[l[mDe[]OQl[OLe]] [mer [sss [ese [[JeoEJd>e[[ [>opDple]leP EF[l Ame D]o DP[[leSeel[mle[[dePefAleeod[[fcO][[[2OD0]]] OF> iin GOT TIE SBI Fe-ol@sss Twn ReviewedBy[: 4r]ea en "Hmom4.n.1f0 e : Onan! Date: __J- (5.9) Seed RT 01.14.00 C2040 or on & Hol eRe GORY 000007 ZF Ato 002950 Pe] lare020 |APFO I Pp Pepoess = Estus M= Metestrus Argus |Oral (Gavage) Estrous Cycle Evaluation | I __|Ra/Cri:CO (SD) IGS BR VAF/Plus | TT TecToe Joao zalie<Tiza] [vo [uso[ja[oa] [Loefioe] [lalzfslea lo srl 0]1e [2][ rs]7 1] fanimatvumber ||| TT [eso >Te SDE[D>[Pe[md[De| [esr [Sw[E[s[o[[mE b[[DP e[l m]e [O] [mez [vw[ce [MolpayEp[ble |e [MD[0[2] [we Tole[>>] E[m[DlP [M[>[De | [ose INTE [oo [e[old[ele[Md[De| [ess [dle[m[ple[E[0[[SDTOO el re] [wes [oleIm[Dr[EMD[ele[Mp[o |z| [oer [vvPBlc mp] [m[De[rf [2[A] [ese [w]e[>[n[D[EP#0[D[DPRTDI[D [DO[2| [oso [mole[moTOl[Ee le Ic n jo] [mo [es[o]Pe[ Temn[ [DDeI|0 M] ~~ TTTTrr rrr Tri LL ~~ Trrrrrrrrrr [re TT [ rr Tr rrr rrr rr Se TTT Lr L rr TTT Lr L T TTIT CL TT[1 T 1 TT [11 T] BPI BID CEs TERT (DRS Fel Reviewed By MW. Mad oa: [150 RT 01.14.00 C2:04b 000008 EXACT COPY [Jt ae 002951 _ PROTOCOL: bo Argus [TEST ARTICLE/SUBSTANCE: (GENERATION: |ROUTE: eco tmae| _ _ TYPE OF TEST: _ | |SPECIES/STRAIN: I P = Proestrus oo -- E roe =Estrus TToTonleelslTorealitall] slelrlolTsea]ltnellemn[ranlenrlan]l MCoewwneJEeTEmTshsTP ptTe mTT loe[roeT Fn[sElTrET lT 5o110o]] CMTuouemssseTee>tTTeeeT[Teow[Iooo>[[Teoo[ree[fTeElopnIooneeT[TEeeTo5Et6To1oT0o]] TCeosw Come TJeNe TTTeasT[n5eSpp[leeoTTeamTloeoT[vooelsel1[o0m[2o0bIomollroel1Lo0o]]] TCCoooomnmJoeTfeeIooTT[o5o[Tsee [[TeeaTlleooT5nm]eoJeoneSmleasllos11a25]]] CCoomn Tue TJ[e5eTsmeTseo[Dol[eea[loooooel[oeolIloeel[5loo TTohIToEl]leeIT1oo0]]] CCCouonmos rTTeve TlfeewITs>mTIIySnTTTo2eTTEmeT[0oo[1o00T[[z0PT[e2o[TohmlIIrso8TOe511r22]]] CTouonnToeT[e5TTeo[I6bT[ooT[0e[TaelfoT1o0 TloeTWPITSe TToo t10o]] OEEDIs0 Glows nr Reviewed By: M3 al: oweDate: puta 1-15. 000009 E( XACT COPY J 002952 -- _ __Argus _ be eemr er s orm]_ mo fp oral(Gavage) :CDO (SD) IGS BRVAF/Pius | Erovtweisn P =Proestrus -- --CTS t72l0[el5s[[s2lFolFrlalslFwelnlonslreeluvlg fCeomwmeT|elTe T5ST(cTETlmToT[OTIFTEToT]5[T] CCoomwe Tol[e5[Pe [nSleelmloelleelm z[Mrs[[2Eflee[[oODD]] TToowm [omes[[sealled[[o[oel[e9[5eloolleo[[nDo112002]] CToowmse Te=l>e[eollee[eellte[lEmllseiles12T[eEllesI1z21122]] Twwnr TTemTI>e[nofgor[eo[f6f0o[l0p1lsol[zmIoDelIcaJ7O]] MCoawsTeeTToeInm@pHeeloe[pTeOlTeolTeoToho0le1|7]] Es A Irrrr rr ererT rr TT T r Tr rr rrrrTrr rr e T T e ] T Cr LL TT TTTT=] Reviewed By: Mn . Mai. : Date: 115.0, RT 01.14.00 EC2-04b 000010 RELooR EXACT COPY } 002953 fL e r op om eee er e] [ProTocoL: Argus TEST ARTICLE/SUBSTANCE: Lomo lp P= Prossirus &=Estus M = Metestrus 0 = Distrus JosiGavage) _ TYPEOF TEST: |ravcicoe snies ervarpuse -- [oate [oofiolliaol]fuly[vsolinfan[ialToTioalyFool afe| [lala sell 7s loe a w0]nl |2]1a ]a] fanwmawmber[TT TT TTTT 1 1 [wo [elmsTe[=D[N{P[em|[[pl0e] [ee Te STS TPT2T0 [N10TETo[bod 7 [m1] [we [JE Imp[> [2 D>[ole [dloDE| [wee [>ToTeJn[oP [E>[Dvle 0[DO] [oes [>Tee mln[Df[mIple [em] [D] [oe [T Teo d[pon le ol [Plple O[P] [oer [eoI>]pz[DDJefe [Ble[]0] [oe [+Te[WD[Pp[ED[DIPJ[e m[p[O]e] [mee [>Te EIM[O[P [[Dn e[em]DO] [woo [ple Teele [MIGTP[Ef [oe[O]7 [woo [nm >Tp |e[mw [PP[DID[cm[DD] [ose PoleTe [Oo[PIE MDP[em[O]P | [osmISTeJe TonIP Je [pope[Mm[D] [wos [>Tofe [m{p[0p[Mem[blo]?]z| [oe [eS vole DPIb] [mp DE [OD] [oor TeTeTop[oP[Oe[[MDDS[7] [se [PTE TMIDIPTF [DID[Pe[HO 2[7| Lowe TJ OF eolorooG p s eolh o[nee[0[P]P |e [D] Reviewed By: M pid: vse: 115.0, RT 01.14.00 EC2.040 000011 rad 002954 ol aad 7 SO wool j10 MKD bp Argus |oral (Gavage) ON _|Raticr:CD (SD)IGS BRVAF/PIus | ExEanes P = Proestrus -- -- = otostus 0 =Oiesus [ATE Toros[i2al[vhol[revoslrba ral 0uo[imo]yoveasliotfone | I il2lsla[sle[7[s]o[10]1]r]13][a] laomainamser| [TTT TT [wo [Je[EIS o[b |e [m[DV[Pe[0[OD] [on [efwin[ [D oE[ DI zDf[oDP 7| [ez [ofc dTO[O[E[DN[D[e[Do[DZ] [ee Im [ofp[e]olD[P[ed[n[D[d[OO] [oe Fo [oT [zr[oP[PD[20[dpfc [2] [res Je [of [0 [e[DAP[er [b]DleJc[A] [ee >[oleJe [mp[Pem[plele[DD] [wor [Te[moe[Pd[D0] [melo[4] [oon [ce [D>TpTelp [poe[ODP[ec[DO] [ree [wm [DP[7[mo[PJe [DID[de[m[D] [om [SIOINTETwIP[Ele[nD[6[AD] ~~ TT TTTTTTTT 1 771 [~~ rrrrr rrr I~ rrrrr rr II NN [TT rr = I HN NIA YOIsSl Reviewed By: mn Maat: Date: 000012 RTO [15.9] 1400 EC20% (BL COPY oF Quked 002955 Argus Fo418-020 bowo IAPFO Ie ee ore |Estrous Cycle Evaluation _lomonage _|rausoc)ensscmvaosiuese =cae P = Proestrus -- -- ose 0 Desins [oar [L+ool[eiaolifsi50li[ayplJsrslmlaeelnb7ala[asolo11l0Laua][nin[ofuia]o Hna]l[uim]e| fpnsmaomeer[TTTTTTTTTTTTT 1] [om [we [wo T THonbe lleell [oolo oe l[gpMd FI[dlDl oOlDDD ep P[>EE[[l DD[[P0Se [TEPP]]] [woe [wos [JPlecI Inm lDlIelne T MIlp ne TlT0eTle em[[lemlm ev[p[ 2 [[D 2O]] [we [Dol nop[Elmlnle[elmIOID] [oz [oe Plel l e ImI fom lp[[I pE>mn II>nT Tleel m [Eo d MMl ]I01Sr 2]] [wm BH I>TelrTele MnfmleTe[l1e| [oo Dplelelm oPTEIDToleJem[S(O] [wo JeIvTo ole [plelelm [DTP]Z]0] [woe [om TPoo TTeolleelleeTmmi[0mI[TpbeleTlmvdl[nDlIEe1M2l]|Dee]] [oes [ows TJ e[e pyl lee Tl e [m Fm In Np Dl [nvl [[eo DeI[e Eml E[oD s P [D]] [woe fe JedJ PIo Olel loe [DIl DIn [D] [wor [oI>Tels[olp [Plclo[plo le OID] [woe np lelelo olfJplnlole[EDD HB] [owe [plelelo dF[Eloln[olen OD] ReviEeweod Hol Wate owe Liss Rr011400 62040 000013 / Sasi) 002956 ree| _ [ProTocoL: _ Argus [TEST ARTICLE/SUBSTANCE: TPEOF TEST: wo Fb P= Prosi Joma (so) 65 sr Varese | -- = sts M=Metestrus 0 = Diestrus [ate [oo Lote ujo, [vooiealrtal sofiaol enlio me [Fol mer] [ Tlzlalsafslelr[s]olt0]n]12]r]mn] masmeer |[T TTTT TT [wo [edISToem[nl [ [ele [m]O]O] [we le dvIo DIE[p[D]oe [m[0]D[| [we BledTple Min olelr[Mp[De] [eo Te Do STole[8[po [ple [vp o] [wow [TeeIm old ele[ple [enn[o| [ows [olele [D]o[ple [m[vle[elo [DO] [rome TeTWIP[eo[P [Pele[dp [DO] [ow ToTeleTOs d[[m[v]o|r|e[DD] [oe Ido[Te mm[y[efmle[pele 0] [ooo Tow ToTe[z Tm[P[plzTm]e[16[DD] [om TeISTnIp[l ee [n[[ D]Pm [7p IM] IHN N H A SC TT rrrrrr111 [ Tr rrrrr 11] EE I II Tr Trrrrs 1 T r r r eT1 Ll AES LTTTTTTTTT] Reviewed By: MMe: owe __r1501 RT 01.14.00 EC204b 000014 EXACT COPY ) 0 atlea i 002957 Argus 18-020 APFO [Estrous Cycle Evaluation | ron al er SO oyA lowengomko | lowi(avege) __|Raucric(osnn) essr varus | P= Proestus M==EMseituesstrus D = Diestrus [oATE [ [Tirolwze[r[sirlalaia]asl[leh]lr][a[|ol|ml1nlTzTT [1T]]7] meresEER [TTF] TechTme |used ["" 2 [9% |i / repo 1[BS[ime[a[enc[it[8 cSrmneameretserTaki no e129t6|p 142 7wr [eo [ug3| p +oI |3 | 1Td TJ [mmSiSmmeaersamras TRakeiand ao[(i5olB oseoPono[feof(w:s2io2n|| TT[ T1 [711] 1/T[| [Swe 1Lo og aloe[Pe [TTLT] loomed | | [| CTTTTT Coo Cee J [EPpl> ef I o> i|sT | l [|e e VAl f T T o l eTTe lp T [l n ] 1 [wee leleolol|oT l/ eT[11 [ras [ows I INn [p[ [PD [l0l o H e lJ e[f o2 J o l t p [ o Tl T T l oT [p l 1] [was [sr [oolp |[ [cm[Deleln [np] [7 [TT1 Come [owe so mole [NPs o e m llo I ml o o[e f A [ff y7[ p m T Tl i T Te T 1 1 a[[T l l 11]1] zo Ca [ [wen [blow Dlofple[71 |[111] [we Info DIlDlo elo TT| TT] Reviewed By: T=~=Z Date: 406) O Fina! was woriund Saerfiesd. 38 /1gy R70131400 802042 000015 EJXAaCeTsCOPY 002953 oo Argus eeFon 418-020 erlAPFO BwCoionsie bo ie oiopm pe to Estrous Cycle Evaluation _|coporigssmuseriss | | TilalSslisalsrlelmlrma]olsTlmTlnTlTalalZ] hMomene STTTETTmTopTlTeTT LLTT T/]] TCoaee JTmeTeolTml0oToelTem TTeo IT TT TT T7 1/11] E CooEs 16T0eFmr lo0lp0T5elTT1 T7ZA1] Tawee TleeTfemImmloa1TpeJfeolfmo TTTTT/7A 1 11 1 ESEENI 0FO 2 2FE 2I 3 0 Tioem IIn>TTeolleeImmloofppTTee TT1A71 1 TT1 1] TCe ow JleeTTnol[eSIImNTTPolleeTTme TTAVTTTT T11] TTwoaw TIoNlDeIleNnItTo lFpllee V1/T1 TTTT1111]] FT0 em w TTmnTloo[lo0l51eTT0ooToall0ep10/A1TTTTT111]] C------ TTTTT 1 1 TTTTT 711 a owed 000016 {EOXtAaCnTteCs opy} 002959 eer Ee] Argus [ProTOCOL: [erase Tree of esr ] _ =Proestrus E=Esms M= Motes 0 =Dies loiGavage) _[ra(vsn)c16r6RivAFcPIues | f[ pomameer[[elTelTslT[TalT slel7[alo T w01 ][u1]a7 ]]] A] [wor [oe I [DIDS Te T om e e[ ml o |Tl | [ p [ Tp l 1 Tf [ [o 77e 7]] [ew Je[Dplp[emp[ [TT TT 17] [wee Tecmolp[Eno [TT 4 1] [wes [ee DIOPIE[po [[T/T] [owe [wer [ |--S H-- TFp--l +e --F l|--e |F[ l |--| o F |7 --7 DF 1 + l--41e F --T] [we [wo T [e el [eSlho[ [p D[l lT [o e T TfTl 1/a /n [1l[ [f pTTp l]] [wo [wea I InNNIDT IeP feI loen[[oD T[|TTITT To/l Ff T [ o11 l1] e ] [wee [wee I IoD lPI l PIe D pIIp T mT TlV P To/Tp Tl T Tl[ [e E 1 1] ] ] [oe [mes [ [m ml lo ol le p Tlpp[l [[ [e e 771f f[ [o oT Tl lT To o11 [we [we [Ien leT lomlleo ll [eA Vf oT Io l T Tle [ TnT T l lT 1e p 11 [we Loo [ JPD lI eD f[me[ID[N //[ T[ TP T 1oT l l [e e T 1l l1 Tm e1 1 Reviewed: LON SZ vate: ___ Ad) RT 01.14.00 EC204 000017 EXACT COFY | x [Uwe J 002960 _ __Argus te 1418-020 |APFO b=wPoroesJ is p =Esins =Metesirus 0 =Disius mEloweamge |Estrous Cycle Evaluation [rsvoncoesoios srvareuse | [ T+lalafals]elr[elo mull] fomavemse |_|[| | [I TTT] [amo [DpPlel[m [1 l[o Tl VT e| [as plei olem [T [To [Tl AT o| [awe m[OJpleT(T o[ lVoTl1e| [ass mole[glo TT[A [1 | [ase [> plp[elon [TT }171T [1 | [aes [oes [No[Plef | |o[l Ao Tl Te| Jaolp elo olp [| TT[1 | [wer [pDlele[l [m AT lT e1l[e1 [wes [ofolelo ZTd TT l[o 1] [es [PJemib[l Ap TT lT e[l1n] [wo In [Pp [mio ele VTTTT 1 [] Crrrrrrrrrrr A] Cr rr rr rrrrr rr [Tr T rrr errr rr rrr rrrrerrrrri rrr rrr rr Crrrrrrrr rr =e I HH Reviewed By: Z >S--= Date: PZ RT 01.1400 EC204 000018 CEXACT COPY | EE18-020 Mo P= Proestus 002961 ep IAPFO |p ____Araus lowi(Gavage) Ee[Estrous Cycle Evaluation |RacdCD(SD) IGS BR VAFIPus [oate Tisoleolutaluo Jinaliwalaw[[| [ TT T 7] [ TalelslalslelslaloTolnlrlnlh] fomawmeee| TTTTT T TT TTTT 1 [oe [plelelo TTl[oTlToTl/1P] [we [nlPlzlo TTl[o1l[e1l/1e| [we [eclolpleTlTeTlToVl1o| [wee [ele md olale TTTAT 1] [wes Imlolplz oInle TTT[/T 1] [ees [nTelefooInfo [TTTVT T 1 [oer [oleTmlolele [TTA TT] [eee [DT [>To(ole TT T/T 1] [oo [Plpo lel [T e /l T[1p 1] [on NTOlpleloop T/T111] [orn Delo lelnlo TT[/1TT[1 [wre [plolelT ol /oTl[o1f[e 1] [won [8TeleTI e N T FTTo [l 1[o 1] [woe [nTole pT lTe 70l 1o [1 l[o1 [os [m(onlpe[l /T T e[l [To] [oe nn[DTPlef [nlp [F/T TT [ [1 [wer Im DIple[eon [7/0 TT [1] [wee [Pp[eI Imio ele[7 TTT1 [J [wee [ploplelolnle [TTTT T] Reviewed By: z= Date: fo 000019 EXACT COPY 002962 falm OLi oomer 418-020 _ P =Proestrus = Estrus M = Motestus D = Diesrus |APFO Argus - |Oral (Gavage) eeSsO | |Estrous Cycle Evaluation -- [RatCri:CO (SD) IGS BR VAF/Plus [oatTiga[iwolmafuma[ielieaal | | 1 [ [ T/] [ [afz] es ra le [10]a mn|l 2]nls ]A] fama | [| TTTTTTTT T1771 [eo [n[Ofplef[|o|"lTp1l7p1[ 1 [we [elelm lel|p |l |o [7 l1p ] [ose JeleIm [mmp [| [[ |[ R1Y /1T e 1 [we mlo DIl ][e TTl 4 o 1] [wee [plelef|D| l|o7 l1oTl T 1e 1 [ees |emmleeTl Te Al T1 eT] 1 [mee lelemll e]e1l 71e Tl TT e1 [meer [nlelel|D[lAoTlTp[lTe 1 [wee [n[ODIe [f [Zo TT lo T l[p 1] [wo Im [O [elope [A [TT [ T [7] [wo [IN[ dD e ITTZ TT D TJ T1 o ] ( TTF T TTTTTr TTTT (TT rrrrrrr = 1] CT TTTrT =r TT1] TTTrlr TTT1] [ IT11 = TTTTT1 [TT += TT 7 TT] [rI rrrrr T rrrrT] gSW ee LT TT TTTTTTTT] roveweaty___ LS So owe prt] wis ele mdalefy a recsnnydyeioff RTOI1400EC2O04 000020 i EJpXAAlCniTe>COPY 002963 p[p erro ee m r1 _ Argus _ _ 1418-020 |APFO Estrous Cycle Evaluation i lomo fp __loral Gavag _|Ratic:co (sD) 16S BR VAFPIus | = Prossius = Ess M=Netestus 0 = Diestus [_oate [igdluwalma me[rralpalima]l | [ | T [ T 7 [ [41]afslalsle[r[alolm[ulalr]sA] omar| | |[TT [LVI [wo nplelmlo |f |I pT l[e1l 1 [ae [DOJ moleJe | | 1 [ [71| [ws [wn ID[>lelo pp] | | I[VT] [esse [Z[D[ [0O |D |[ ITe AT D1 Cowes [mM [Elmo | | | [/FT 1 [wes Jep>(ol|e [l |pI/o T[l1 [wer [6[O[s >onlel | | TA[11] Ce mo oppl | |[7e 0[11] [we ele[D>[ole ol[| I/T[11 [ow Jefe[slele [l |e fl T[ e[l 1] [oo Jelelm(Slo ple] | [7/0 T [1 [owe lclp[pl| | 0[l /Te Tp [[e 1] [we ple m[olp elm] | 7I I [] [wwe [NID[DIP[polo [7/7 TT[1] [wes [e( [ElD en [D 71 [ [TP [] [ws [Dd De elV m T[To [1] [wor midlPlel [A oi [n |l1p 1 [se [DN IDIPle mlole [71 TTT[1 Co plelelmiTo[ le Tl Te[y | Reviewed sy: QO STF> vate __2il RT 01.14.00 EC2-04b 000021 EXACT CoP QF wie i 002964 sep _Argus 1418-020 IAPFO Estrous Cycle Evaluation I hP o=Pwroossis Jp ests M=Metesius 0 =Distr lors Gavage) _|raticricon so) cservarus | [ [alzel l7 o soefta 0]]l 2]s j] [fpomaorvoomeer|I [ TToTT T eET[m || l T [ e7 l7 oTp] [wn [we [we J JmenfIeopI [DDlePm T[oEd o pol [[ |[o T | | T l [| [/V 1e 7171 n 1] ]| [[wwows T mlno P Il P ETpe ml]ep[l [ |T | e [ A7m [1T To T T] [wee [wr [oe [ I[mdml[N eDImoT [nDImPO [oepllT P me| [A e | ZT[N ZT TTTT TT T 1[T1 o ]|| [wo TcTEIM[DF[elm[A [ T | | | | wm ele TMD [eo ZTTT TT [1 SR A [~~ NN HH HHI Trrrrrrr Tr 11 Lrr Lr I~ r r r r rrr rr rr r r r 1 r1 [ [ r r rr r rr r T rT1 T LL rr rrT T =TT] T Q@mi iso ReviewedBy: < NZ Date: A RT 01.14.00 EC2:040 000022 E>XAACT BOY! 002965 fr pre pee) fl418-020 pr FmEe, komo P= Proesius |APFO lp Argus losi(Gavage) [Estrous Cycle Evaluation | _|RalCrCD (SD) IGS BRVAFIPIS -- [oare Tisalio fina isafenTo[lTwT aT laTa/ [+2lalalslelr[alolm[nlmlulAl humane ||| | | | TTT T[I] [wee eo lpleloo [TTT[A] [wz [os [cD[plP | [ l|eTo 171m 1] bp @lel TTo TT >[l 1/e 1] [oe Im[IvleoleP TTT[fT] [wes [woes [[pzemleDimpiloeloellee||[TTT TT1//1 T1 ]1] [ww Je o(piole op| TTVT [om mplelelo lp[| T/T 1] 1] [ [oows[egelmellpelleellmelp elp e [|[|V[T /TT1 T1]1 [Cos In[plefmio ple [we [plzfDInlole | AT 1 [1 T/T 1 T 1 [ow [dele[molele [ose [a[Plofmfo ele [1/1TTT] T/TTT11] [ows [ose [ele mlel [ [e 70lTo Td 11 [Sole piolele [ [71TTT[1 [ww [ew J[zelM e oP pJ(oPloelm[[ZFLT TTTTTT[TT1] Cow Je molelelnlp 7T TTTT 171 Reviewed By: LZ Date: _ ber oA) a #454) RT01.14.00 EC2.04b 000023 &AS _ late-020 ---- |APFO Argus 002966 -- ko ko P =Proestrus E=Esius M = Metesius D =Diestrus IP [Oral (Gavage) -- [Rat/Cri:CO(SD)IGS BR VAF/Plus -- -- - \ @ LL [lalslals]e]O80] lhe] fpsmat omer111TT 1" T/T [oso Tele Im DIP elm] | | | 17T 1 [we Tml Too nleT | | e [T l /e T 1 [we [wmlm op l[ p|le7f 11o1 [wo NDTolzlolo DO TTTA TT [wos TM DP[Em |[ 71 [ows TcIMDID| [ |[EAm] [Tp| [wwe InNTOleIDIOT le] | ZT[ [T1 [wr Tole ImloTole Je | A | 1 TT 1 [owe Inlole plo ZT n 1Te T] [owe INTeJeI [m [DA[ [ DT ITP ] [oo InTple miplo [eT TTT1 [ ~~ r Tr rr rrT rrrr FF ~L rrr 17T IP rr rTTTT I I HH [ rT r SS r Tr LL rr rr eS 1 rrrrrr I= 1 CL [TTrT Reviewed By: Zz vate: 454] 7 C0 Pri. en oleRT 01.14.00 EC2.04b 000024 1 & Al o> 01243 ESTROUS CYCLE EVALUATION F1 GENERATION FEMALE RATS. 000025 OF aluloa | 012432 ~ [roroeat broooom o P=Proestrus Argus [reerAvLeruBsTANGE: ~ [TYPEOFTEST: -- J[Eovo Pacem mune| F1 ___lorai (Gavage) ____|RalcricD(SD) 168BR VAFPIusE. ME==MEesttersutsrus D =Diestrus [ATE Tovul dh lly TivolEpos Ts alsisalone[opaldale [oooTrae] bs CefelelTelsIhlalnlinivl on [of |# wefou [sme] oc fam 0[me [yn 3FLperg en ry recta 1235 wr us te 5 od [P65 aPl #3 [pee [of |e| jaf [pat |* |Bo fos] or |iate |e ponPoest | slat so [oi| van {rye oa [imi] 905 oot | 7 Jr [igo fee |eSmearvs r Taskeen e[27r7 oDLilo E ST E eBen [Eo[nef]e| <7|Jy eI[ScmeEarsermRead ve eLa Lo [20|5g [REPe [E Bn [P2[P7Y [moa |epels plelob[Fle MID E]D [[[p12o0oe8y [ [ [om fe f[Jcpll p[loo mleolo leleo] [[[EnD[[]Emr p[||EED[]ll LuP[[IDEDe [0p7]]] [mo Tmolrleloelel[e Peo[l pe o[lPlee[l D]m o] [o> TelelnInlpfe Tem np [pIPIr[po] [l> k [[pDlPerlioe[ [nepmJoe [dulloelpe[e[lmm [[>p[[PE]lDco|] [[[113Z2aag15[[l enlPe polpol l[pple >e[[[emol lIemv[llo neelloel e[[[fmneo [[]DOP[I]l cDz[[[ePDp ]]2nL]]] ReviewedBy: -; 9; @udhh CEI '. Alor, Date: OR ab prformaspinsi EA RTc01h.14.o0R0 EC2-0"4a 000026 EXACT TORY) SF alos 01243. 3_ agus _ Pe Lomo ttn oP2=wEPaorosss lr |owiGavege) |Ravcicoe(sn)ics BRvAFPuse | B== Dotoossrsus [afo[ mtanveomeT e[|pwaTfshlTihlaohThl[ofT]s, Jool wallsa=TllsT nsulT sTslesTw] a0Tl]s7T ra]ls1a nds]Tnsdom|id| [30[mor[[&o[o [ofc [Db[PTE Imp] [[23 23g1[[o SPo[oc[mov[&fleoTlevmleel[eE[[eZ]DATIDZT[]PrFD]] Smtr_f (Lsitlear oom __fotil 236 [offre[elpfo[vieImp[FTEImo| Sag Inlemla olelem nlp[E[D1DTp| [370 Tela[pnp[o>Ip[np[AIP[nD] [[[31z344y2 [I [oeln leeJ llooe lffooel l [leeofle Teco eml lp pe[o [l0PlEII|nrl eD[[n ]2Elo ][onPp||| [34s [12 Joellnmloplnellpnlloef[eW[eIlme[Pee IDI]meo[[[eP]eE)]] [24g [*lclo[spfe[Mvp[[n]o[PE] [[ [1335553052l [Inme | pfl n rg [[ el[oo o op [[ dD] o e pI][[ Pn pm[ [p bEl EI|l MEM p ITe SFTl D j[ PmIF e pw r]|| [1358 In[p[m[v]o[>led[o[P[ED|p] [-- 13-- 89 [+o+ p[1 plese[mv]nl1 rT[eT[E1[p1[T D]Hr| OOmeh 51-01 epesgeo BBs . `RrotTecoEacz ~ 000027 [BAACTCOPY 012434 Tm Le cece ore yo _ _ Argus _ 418-020 IAPFO |Estrous Cycle Evaluation p| osses P= Prova rarememann:|lRoOmUTaEn:se |S|PrEsCiIcEiSc/oSsTiRsAnI)Ni:cssr varus | = Ese M= Motos D< Diss [o[atTeiTal lie b, [ssllaghll[ss[veull7s[nsallovosls0mr]oaltcl[odsro2rie]sS1aoal]is]l] [Cen[>Tole BrnJo [ve[m[m[0 [Ds| 3[[1122662%T[em[opp pT[Pl>eTmorv[p [Imr[pp[[PD]rz[[EDDp]] [[135% 05I Innlopl0 el&ollmolTeol[vey [ [or[belme[[)E[l7o[[DE0]] [ [1322%8 lJee [ploo[[eolPpTleo[[w>l[ocllpel[eM[EN1P0[EDop]] [ 1329 TeloTolp [efo[>[ve[5p [ND] [ In] [[32382 [ellpo l[oenl]?e[seJloolvtollee[lem([nm[[DDI]D[[2m[d>]] [ 28> [se mao e[emp oD oD[fr] [[ [28388299[[ Twos apdIo ep [oo] p>e Tleec [ [lEb[e lm coll ne[|mnPe[I[l pFllo ro[[l EDlpr e|] [292 Te[oor my[vpe[m0E[[n7][DE]oE]] [ 3[S7D2oaIhosn lelelolnle[ennR[pobn[77F, ISD] ~ roared M (Coia l @ revwcheR7f 01 14s00 Es C2 00 000028 [GEXrACeT COPJY 012435 yo wus _ [roe Le orer e a 118-020 Ea ee les e e] |P=wrooms eam [J ER IAPFO _loral Gavage) |Estrous Cycle Evaluation | _|Rat(5i0)c16r5BRivcAFPoIUnS [foo[ iamatnumeoeTrT| aomlel2| dh[hislslhTha[T lods][seoT fo7ls]T eaoolT fetnT 0olfsniFsT|loTrsdawsTa]flr6s1 asanl]a1 fll| [A mpfr elmloTen[>[PTE [>]] [Hor [nfe[Coole[Elm[DP[Els[Dp] [boy [>[elnioPlelelm[Dp[EZ[mln] [407 Tw[oe[Zn[ole|e [mo[Dr[Db] 3[409To [Fle ]olr fe [ep[DPE] [goInTelelah lorJe Im[pp[FETC] [ [y Hs RTpe lel [no lol s{o ell e[vFp Ilher [bel D[E]Ze ]F[[lEmo Do]] [ae [Pleo o[p [e[WI Tp[ge [NTP[ETC] Lg [TTIler leT lo r lpler [el[FmT [r l>T ]pp7 l|pe ]] [ T~T~I= rr T rT rrr Tr TrT rr TrT i r rrrr rr T rT rr r rfrrrrr ri 1 i TTTrrrrrr TTT C NN NNT N TTTTTT N THTnT=1 TT Reviewed By:_([Coast{(]. Ly ee vue __aforfs - RT 01.14.00 EC2-04b 000029 EF ASTt COPY 4 01243 [aPfot rorn Ee] ] Doe Argus _ 18-020 laPFO Estrous Cycle Evaluation b _ Ft |oral (Gavage) |Ratci:cD (5D) 16S BRVAF/PIus | P= Proestrus E=Estus M=Metestrus D = Diestrus [fo[ omarTT|eonla1lzshlT iisleThTabildTssofT o[eslT iro]TnalT lomoelTlmsnlaTrlnsssTluollrsT-sliTnswa]1aalul1u]fso] [42 Ineo[olele[wivTeTelp =1D|<| [[[41m423280 6 JTIeo[n R l mo e n[ plo cI[Dl e[[]~PMe TTnoETIl TFo[[[m EEDle2l m[1s)[o [[rop]|] "uz [ellnlo]lplee ]MWo InI lpn [ol n]e o]l r[e ] [[[44423323 ll[enel[lp np lpllIeololmlp[ el[eDeIlE[e me[llm pne]IDl PNI[Ip Z2=[Tl PDEI[]se 0]| [[443992 I[emloiIp >[loleplleleelmlp m[opil l[pvFo[E]FlTIleE[eDl Sl[oee|| [744%[op[po lalefTeolel [DoA1l0To P| [[4w5s0a[[nD[cp[[oolloelp [[oofvoT[oclmp[laefBlDn[InE[lMp][Dc]] [ [a4sD5weTh[ [e o Abe 510l 0lo o T[e[ el [pW[D e Em[[] ] mm[pMp c [MUOFl l LT[EPe o M[]] ReviewedBy ra Lape vue ___ sao o RT 01.14.00 EC2.040 000030 FEXACTCOPY OF lex 012437 Do Argus __ froeeas |[TEST ARTICLE/SUBSTANCE: [TYPE OF TEST: = Ib418.020 aero e [SPECIA ESISTRAIN: P=Prossius -- E=Estus M=Metesius 0 = Diestrus [pare Tolshh of Todd,Js solsnnsatro Jorn[melov Jsaoa] | b[ omawambeT r| |+|[2s1TTa T[l TsFost[[ Tn[1e 2"]l r]17 m] [#459 Iolo [np[Eo[>[DIF[BAD]= [[rm] [ 7465TelTTn pe[eleIn|p [AF[E [0] [Hex Tels DTpTE [mv[EF EDT [Er] [ Jey I 22x TeT [eoe Ioll oToelTe e?[[l 0ebm[pe A[PZl Er[[Dms [s0|] [924 InTele dle [ele [m[BPIZul [P| [142 lelofoIr [1422 lelnIoTp lEeTf[ oO wO orp np [[NOe [rFF [[d E0o]] [rI rr rr T rr rr rr r T 111 711 rr Tr Tr rT171 FF rr rT 1 1 r [T T r T T rr SSr TTT T TT 11T ] L DBEl STR TTT= u ReviewedBy: 2d is 5 Date: s/oefo) RT 01.14.00 EC2.04b 200032 EXACT COPY aluiox 012438 J _ _ Argus __ fom Jor tase | 118-020 |APFO Estrous le Evaluation pe Pfl=oPmrkDoms lr lorel(Gavage) |RatiCr:CO (SD) IGS BRVAF/Plus J 0W=eDioesstiuvss [oate [shuld [hl def freo [sot [oo[sr als-wals tu rsd] oataldib| fo[ movomle1|l|2[s|la|lsle[r]T aloT fto1fnT[rT l11s]11a|] [432|elnlnlp[ele [DP[Pp [EDPIc] [ase [198 [[e8loo[[oepl[pmloe[[Mel[eo[]dE[oep [[ADlpo[I[0e]] J[H Mio Tl ele slel lole olleel Pfelp feellpl o[ lpeo Ean nl [[PDp IpL]] [T2 AH4 % | olw elcl l> ol[eel [[welo pl[ol epeeo [[EEll rNIDDp ][o7]| [TsHoecJ [mle el lon nllel w[dello pe e p l p mp [[Dpl E [DD p ID]] [1[550025[ on nll pleolnl loo bl[l oe[o mEoel[[pp DIIDl TD)IIo no]] [[1i550078J | Jee Inl lelop mlpp lll eol[[eEe Eo llmol e[]m Oo l 1[rn D[][l EEdT]oe Pr]|] 50 [i505 ne lrll celn olel [peo lell o[o DIl P [Ev I l Dp Ie F] [ [i54 lk J l lee[ e l n lle ollel wleeic l lpp[ le o l pEl le peo o [[[DOAl[IIl p0v D[[IDEDp I1IDP]] si7 C@mens-g] -or olololle Er] Reviewed By: 2 UG LZ on Date: 5/et fol J RT 01.14.00 EC2-04b oovesz [EXACT COPY | > Quo J 012439 NE Argus __ PROTOCOL: fo MxD ITEST ARTICLE/SUBSTANCE: _ ___lorai(Gavage) eeTYPE OF TEST: ____[Ra(SvD)cIGrSBiRV:AFc/PDIus P =Proestrus =Esis =Metestus 0 = Desirus [_oare opelshJhspapllswe olssd ollslwole ialr swol ]s=eo aedsel) fa[ ma T+ 1 |l2| [s[af|s[|e[17]1e]oTfTro]T n]rTz]T1sT]11] [159 [oolplepiolele[o[plPT=I1od] [sal le oplPlelo olelem]Al>T1>e| 1523 le [op [olen[> [oe[Mn TPIETn] [150d[eolefolplPle [vp Jolple[JIo[[eP] [522lelulolon Je Wip [DIPIETeIm Io| ~[152%[no[rled[op emp[ETc] To| [153 nlolr miele[Do[elmu[DIo[lprd] [1533 [o(olel|ee[lmm p[lPo e[[ ot]vn] [15> [>[e(ololplewlolp[Bllrol[D] [1522 [nlo ol v[r epl [p|e P[=l Bk| -- rr r rrrrr rrr rrr r1 rr rrr rrr rr rrrrr rrrr1 rrrrr rrr r rr rrrrrr rr rrr rrrr e1 rT] CC rrr rrr rrr CC rrrT TT] roowsay (CoilM.a ae ~ 00-001 YA `RT 01.14.00 EC2-04b 000033 EXACT COBY OF alex - 012440 --_ IPROTOCOL: _ _ Argus ITEST ARTICLE/SUBSTANCE: TYPE OF TEST: _ pbo mro s Jet oral Gavage) RavcicD (50) 65 BR VAFPUSE I gWeme:ms [vate Tsp] of loh [Jew slow [gusalsiofsno|swale[otabf | fma[ numverT|4| l2[|af|af[s| [e[ [r|s[T oft0T ]a]rzT ]1 s]1] [1541 [wlr lmslelelo[plr|=[o]od| [5H Jemlo [peloJoe[e[aD1E[E[mn] [1545 m[olp[ef [o|v]e[m[D]|F[EDs| [SH le[dlplele [o> [p]ee[p|D[e[[0e] [isig [550 [[o lel lmolplppll e = M[ o[m [pEl lpeol|[MlP[lp De]]l DE]]e p]| [1552[mpnlelDlo[de m0|[PTE[D]>| [1555|e[>lolple[o>[ple[DJ|E]ET]D | [155%|e [oplolele le [wor[lp[ope] [sto [ms lelolor[EWpp[eT]O]D |e] [16S[nleleo?le[En] |e[PEM[Dp] [J5ke [elo oreo[omem[P]D]D[b| [521[wo]rleln[DrJe [m]o[P Je[Mo| [[51522>6[ [ o>e [oll plee [loefl p[oe[o lpel[pl p[[E0[[o De]]DEm I>p]] [523lelo|o [>[l olp e [l DIDe JEl TE[e AM] Revove (Lownst]l. Sos OBoTkus-e4._01softo i) ror EE 000034 EFXAaCTsOGY | 01244 " Argus pe mw 18-020 laPFO Estrous Cycle Evaluation | oMKD__ le loiGavage) |Ravciooe (sn) i65 BR vAFRWSE P=Proestus E=Esins M=Metestrus D = Diesirus [_oate Talo [eh Lheima yoseJownesos ds alcpp valsavalgh | b[ owsTeri ||l2|slal| s|le|lr[aT fofTmlCnlTmlTrn1]n1] [155257lm e[ree nosloollee( [Ele olnl lb[o PEp [PEp I]DDe ]TpP]] [15edJel [lope[vo [olp[El [EDC] [5i8s9n J[eo[leMloelloolfnpplleo[vMr[[poellnelPl[EolhIoTrrl|] 1m5938 [[opleolloe[oellemJoe sMp[rp[[pelpe[lNNTPIIDET]IScP]| J r oo Jr z nr lor lelrer(n r [r or lr er [crer[Dr [Dr Oletlerrlnid] r rrr r r rr r r r r rrr I rrI rr F rr rrr=F rSeNsr rd IE IF SS rrrrrrr Y rrr rr rT TN oJ rovewsay._(Corestll]. gan owe: ftls RT 01.14.00 EC2.04b 000035 EXACT COPY OF awe 01244; Argus D1O8S-A0G20E: | om GENERATION: APFROOUTE: |SEpsetcrioeusstCSytcrlaeinE:valuation | ouiioaage | PaEDi053s 0| P-== PMrseoeitsestrsuis.s -- -- D -Diesius [oI we Togdlo [saJ ver rave Joose) |S eol/onk [o2 huor| | re ;Tech/Time [iiy3 [aa3 [|S23yY [|fporos [enowr [7Ifo2ot | a0:s| [oCellr Twso TolTAoTa dFE TE Tomi Tom[ion [10[1st[R010 | yee| |vSerearrRsveaeFons [a7 |p| [fe [0i06a[Go[50| [waowsen|[| [1204 | [oom[O [Pe Tp 0 | [zoe[D> [0 [TE [Tm Jo [FF| [B03 [Im[m [Oe mo| [20 [0 Te[m [Do To TF TA] [=i [Db |e [E [wm [0 [06 Tp | [za[bpJo [TP Tw [6 16 [le |p[vt [E [sm [[BD [TE | [as [Dd Jo [bp [Bb TeTe[0] [122] |PTE[m [OD [0 TE A| [239 [Dp [p[EF [vw [FF|E [ 30 [DE [m [De[EF [mA] OO ReviewedBy: 2 24. 4 il Date: s/o t/t Vober pupa em RTO11400 ECT 04a CE MAA ol 000036 EXACT COPY | oe j Argus 012443 418-020 [posace: APFO GENERATION: |ROUTE: Estrous Cycle Evaluation | Species/strain: 1 { omkp [Ft oral (Gavage) BE Popes - E=Estus M=Metestus D = Diestrus [ose Tgzon [smo[Tater[5250[soem [rar0 [Se8er] +2 sTel1 s[el] [woes|[| 1 1} [21[[moTp le [ETP| [=x [2[m[ [CTe TD[0 | [335|p[7[m [0Jo TETg| [15% |[[m [DoTETM| [12%[[wm [D0 [P Je [m |D| 20[ee[wm [0[wn Te [e | [ou ef [o [6Je [>JF| 124d oS e [m[Do [ Te[2| ws|p|p[[eg TbTo | 2[et[ee[EmTPTe | pug |Mo[FP [EI Tp[P| 25 [eg [0 [D[Pp [e Tm [HM] msn[e1 [pm [610 TE Im | [155 |Df[o[ole TeTe| [5s|p |Em[np Je [2[E| 1351[z[[m[ 5TeTE] 1 1TTT 1 ] r1 T rT 1 TT [1] CTTTT 1 T= Reviewed By: od 4. Ayan Date: _s/t/s z RT01.1400 EC1-04b ooooxy EA [proTocot: 418-020 lposace: L wep Argus [Test Article/SubsAtPaFncOe: (GENERATION: _|ROUTE: [fr ee) 012444 [Type of Test: ] estrous Cycle Evaluation Species/Strain: Fen sR P= Prose M== EMsettreusstrus 0 = Diestnus [oeTTz+ mn[ [savo2 r [sas vor[S asofss am [5e 072[507670]] [ [w2 an2 es[| D| p[ |E [mo1 IDT TE |} 2ud | [b 0[ [FfE[m m[ JOoJe e[ [eE[D 0]| pe7 [>[fp [Ee [moTPTF | [2[ple|e [m [375 |e 0[0 Jo [[Bb TE] wm To |e| [om% 3[ | e bh [t 0| [ E[[>> J[o* [TDFD [Tg F|| 3a |ple|e[m [5Te| 5% |blo|e[mle [D5 TE| [38es>a [[pDlo e[[I0m [[ooo[e g [[F7 E [ Tpg|| [3% [2s [|&Mm [[mo||pD[[EP[e= [[b0 > [[g D || [389 a[ [&>I[m[ [02[Im[eeTm e[I'2m ]| Tw[&lm [op [0[ge TmTp| a1[p[6[m [60TE[| TB Eiieme By: _[JConstl (J AZ x vate: __sfief RT 01.14.00 EC1.04b 000038 PCRawGET EI re [ry time | la18.020 DOSAGE: 1.0 wkD Argus APFO GENERATION: [Ft [ROUTE: oral (Gavage) _ 012445 Estrous Cycle Evaluation | Species/Strain: | am | eo, EM==MEestetsutsrus. D = Diestrus [ose T[s+ ua[sa2 vorlss ato[soasol[saswsT[se arol[c7en]a] [[mwwapnod wee[ n|0_[|2|[[ [wm T [0 TO[ T T1F]| [doHeys| |p b[ TE0I[omp [[eDfp Teo TF Te | Im Tp [0 | fo Hs | Mm [DO [Db [ep Dp[[m Tw Jo To [0 | TO[8 | a Jase [ |m Do e[[P [ [gmTomT[0o5 TTee || ~_ig [eT m[r 0[Pr JE r Tm[r sm | ~~ r 1rr T rT r Tr 77' 1 I~ ~~T T--r 1 T +T7[ 71 1 r rrr ~1T T T TT T[1] rr r TT r rr rr r sr r rrr TS CT r T T TN] Reviewed 8y:_( 70 410) Lo ou Date: fosfs RT 01.14.00 EC1-040 000039 Y EXACT _ Argus 012446 418-020 |i somo foosace APFO Estrous Cycle Evaluation fp|GENERATION: ROUTE: |owewms | memos| Species/Strain: | BeTruT e[aelse a e ioeT[senT[reave[[s1ma]l PDee mmTe TT sETTos[T0ETTEET wJoo[[e2o|] Mab IDTE | Im [ge [D[E | FhlBaepTTT TEnTTeomT[[DeoffTePo T>ewm TTJwEo[[[s00p ]|| EE A A PC CN No = wy [elm Tm Pp TE |o[6 [Im [0 P TE [fe [Mm Tm | | gz|b[EE[bpp [ole | [us |e[mo[gle [Db 10 | ElaS s TTbhTTmw0[[DF 00 [{7elIenC T[Dm5 T[e5|| TAc eT1RT7b[0 FeTETNmJl= = | E IhT ae% I To oTIp0 p[|A Ef[ri [Cp oBo [b D0p Tfeo || Reviews or: (2] 7 vehi " % RT 01.14.00 EC1-04b. 000040 [EXACT COPY 1 5 au los | rai Argus 012447 418-020 APFO [Estrous Cycle Evaluation | som [posace: (GENERATION: EE IROUTE: |Species/Strain: | FoR -- Re == Etoenssts 0 Desius [ote [sma [Soo sana [saa]se[saa[26a] (e weesl ||sels e1l7] [ C4 a3 >|D pwm |[De0 [[eEel>e [ [mo|F0]] [idehear11p5[[C [ |EE[mpomm [ TF oTTEF|| [7fqgn [|ee e [[wmE[[DpD[oPo[ le TTF w T [0F]| [ [4 a7w7eI|DD> | [fp F [ [ [[wm > [Pp Te| > [P [E| [m r ~~ec[po r [Te r mw To TD| ~~~r ~ r r rr r 1~~r ~~ T r Tr T| T Tr ~r~r sT rr r rr Tr r rr r rr s Ss Td r rr r T rT TSTNN Reviewed By: _ (4 qg Mes vate: _slotfel z RT01.14.00 EC1-04b 000041 Oe } [PROTOCOL: Argus [Test Article/substance: [Type ofTest: 012448 nN bosace: JOS GENERATION: o_|vRaOU(TGEa:vage) SpecRiaeiCs/StOrain:00) G5 68 Br EIER ECE P==Esptrusoeswus M= Metestrus [sao[soi[Gasor[Ste[50701] [a[ wwanoveer [| + |[ sl T = se T 7] [m2[Dp[PE[nw [DE| [may TpTe[mw [D> [eT [D | [MaeTNTPTF[wm [oo [0 [z | [Mes [D[0[0Je To To[F| [4[DTo[PF [EoToTgp | Lu[em Jo[fF TE Tm Tp| [4[DE[pm [DO Je TETe| [Mie TeTm [DTP TE Tm TM] [492 TDPTE[wm [ TP TE | [Son[fF TET [DETETZ | [1a [Dp[ooIv Tp[e | [1505 [pTElm [oPTF Tm] 15e2 [DTPTE Im[3 T [TF| [508 [pn TFTE[milo [TE] [ [5 15 50 >[ [&Tp m m l [pm W o T T0Fo 7p T1P0]7] L154 1 Im [op [Jo [TD TD] Sle [D> [Pp lg [mv Tp TF | [597 T3To[0[Eo[DE | [Shh JDTPTem[D0TE | L19R2 evieweB[ yd. (0tfp J TLZEaucm 1 ip7 o[def_FslafTEiy Z RT 01.14.00ECT-08 000042 OF Wie | PROTOCOL: Argus Test Aicle/Substance: Typeof Test: 012449 7 | ome IDOSAGE: |GENERATION: lRoOaUT(GEa:rage) ROBE |Species/Strain: ISTE Fe M == EMsettreusstrus 0 = Diestrus [v[ ate [55T[s2 anoT]ss av+ el[aso5[s5 [ [52e00l[52780]1] [5 [owa2 now> eer[| D[| [Em|[>[ [P1 TE]1 [54[>[po [Pp Te Mm [gE| [132[>[kp E [m[D[FP TE| [1523 5 |[D [EF [m [>[Dp [E[A] [[oo [o [ [ [ [0 | C15 I>[ [mm [ lp [E[A] [1524 [D> [ob [Pp [|p [OTP | [[5 15% 37| [g 6I [m[ m[nO m [DO [TFE P TT D o E|| ~~ [ ~~ r 1 T r TT Tr 1 17 | ~~~T ~ Tr T rT T 71 1 r TrrT rrr --1] 7 | r Tr Tr--r ~1 T [1 rN T 1r T r T rs N r Revevestr (C ] Mao gr eTd re rOT vaTN RT 01.14.00 1.08 000043 [EXACT COPY JF Ato 418-020 Argus APFO 012450 Estrous Cycle Evaluation [ose Trpgel[$900[soo[Saso|SUolsang)[Sapa] T CC T a ] sel7] [owacnoees|TT1 [54 [=[wm [ob [> FH D0 [E| 54 |plo [eg [wm [DTD[eg | 55[pe[o[5[V[D ETE] Je[[0[[mp |e [E | B48 [pp[m[0[Pp Te[AM | [550 [Do [Pp [E [p |o[EF | [1552 |D [e[m[ee[Dp [E [TM] [555[Db [D[E[m[D[FP TE | F557Tetm[01efe [81D| [Isse|D[5[0[ep[DTE | [50 [D> [D0 [Pp [T|D [D [E | [Seq [pg[m[>1p [2 EBT] 1568|e[mD[EE [m [D | 15 [OP[Em [DO p [E | [1521 [[mID [Pp TE[po] [ozs [&[o[[oe[D[0] Bh [6[ppTE TMMID[eg] 158 [D [Db [E[m[OD 577 [em[DE[eg [F[E| |D Te| [1583 [pp[EmID[>[FF] Reviewed By: PORT 5 ot Date: 000044 ILEBXAaClTesCOPY | : 012451 Argus la1s-020 APFO Estrous Cycle Evaluation | 30.0 IDOSAGE: m0 [rt(GENERATION: oRrOaUT(GEo:vese) Sp RaiCHCO0(8 ecies/Strain: 0)163 8 l Sseteoo P-Prossius - -- M==Mestiessinus 0 =Distus [owe [5950 [sarai[Sita [550 [sent [500 [rag ol] 1+[2 as]s el7 | [wane| ||[| [| [5% [Mm [bo [[wm [Do[EF] [5% |b[fe [em[DTP le| [587 [ee[wm [bp [Pp [ le | [132% [Pp [|e[m[OD [De[4] [1597 |e[o> [D[> [To[FP [D0 |] [99> | [eTE[mM | [3 [o> [Pp [m|p [Ff TE] [boo|pJP[EmID [PTE] r ~~ r T= 1 ~~ r-- Tr T 1 1 CC ~r ~ T 1T 1 ~~ rrrrr ~1--rr1 r ] TrTT rrr rrr] rrr rrr rT rr -- rrr CT 1 TT= Reviewed By: (Dennetd J. Mo pene Date: _5/sd/0 RT 01.1400 EC1-080 000045 EET EER) Br ten