Document QJvjZRdZ1rKVpZMqJ4bBYMXR8

7039 Chemiad A btlrads 7040 Vol. 65, 19GG 33--ALIPHATIC COMPOUNDS UUMNCl I. UllUOM AND HAJUtY L. YAL1 Chlorocarbons tod ehlorohydrocorbone: chlorinated paraffins. Chlorocarbona and chlorohydrocarbons: sflyl chloridt. B. it D. W. P. Hardie. Kirk-Otkmer Entycl. Cbm. Tteknel., 2nd Ed. a FOon. Kirk-Otkmer Enejd. Ckem, Tteknel., 2nd Ed. S, 205-15 5, 231-4IX1964 X Eng). A review on chlorinated deriva. of (1964XEng). A review on the phys. and them, properties natural or synthetic higher paraffin*, without regard to whether (typical addn*. to the double bond, limple rrpt*cements of Cl. the potent material b no;,nally solid or liquid, including proper- formation of atlyl ester* and of N compds., and synthesis <4 ti**, manuf., economic aspects, handling, storage, and use*. 39 complex n.ols.), manuf. (mechanism, reaction variables, emu. references. VNJZ practice, feed prepn.. reaction system, and product recovery) Automatic preparative (a* chromatography spparstus. Ya. --safety and handling (toxicity, precautionary measures, an.i Jg. Kucherov and A. F, Lixogub. NtJltptrtrahotka i Nefte- remedial treatment), and uses. 25 references. VNJZ Him.. Akad. Navk Ukr. SSR, Rcsp. Mteietdcmtm. Si. IMS, Chlorocarbona and chlorohydrocarboas: ethyl chloride 13S-<0(Rusi). A 1:1:0.6 isooctane-octane-nonane mist, woa D. W. F. Hardie. Kirk-OtkmerEncyd. Ckem. Tteknel'., 2nd FA. aepd. in a column of 0 m. length and 16 mm. diam., N carrier gas 5,140-7(1964XEng). A review on the phys. and chem. proper- vciodty 0-5 I ./min., Wheatstone bridge current 170 ma., re- , ties, manuf., ccohomic aspects, standards, handling, toxicity, mvW sensitivity 50 mv. Samples (3.5 cc.) were injected at " and uses. 3V reference*. VNJZ 112*. and the components were collected and frozen in glass tubes Chlorocarbona a.id cb'orohydrocarbona: dkhloroethylenes. at 0*. The yield of the components was 55-60%, although by D. W. P. Hardie. Kire-Olkmer Encjd. Chem. Tecknal.. 2nd Ed. condensation of the vapors, the yield could be increased to 80%; S. 178-83(1964XEng). A review on the phys. and chem. prop- the purity of the collected compds. was 99.9%. BNJR cities, manuf., and uses of 1,1* and l^uchloroetbyleae. 10 Suhim of activa nitrogen with organk substrates. IV.__reference*. - VNJZ Iaooeena. Terukiyo Hanafusa and Norman N. Lichtin (Boston Tti- and perchloroethylena. S. A. Miller. Ckem. Pretest Unrv., Boston. Mam.). Can. J. Ckem. 44(10), 1230-2(1966) E*g. 47(6), 268-75(1966XEng). A review of processes for the (Bag); cf. CA 55, 17622r; M, llOTOd. The reaction of bo- manuf. of CiHCb and CiC' . The relative feasibilities depend prax with active N st 60*/2 mm. was investigated. Products on the availability of raw materials and the utilisation of by- trapped at --196* were HCN, MeCH:CHi, CHi:CHt, CA, product*. 18 references. Paul A. Haas HClCH, propync. EtMeC:CHj, (CHt:CH)j, and propane, g Chlorocarbona and chlorobydrocarbonffi chloroacetyiene*. Monomeric product* trapped at --78* but volatile at 80*/0-01 D. W. F. Hardie. Kirk-Otkmer Encjd. Ckem. Tecknal., 2nd Ed. TM. were d-tnethylpyrrole, pyrrole. Nils, l<yanoisoprcne, and 5, 203-5(1664XEng). A review on the properties of mono- ami at least 12 other unidentified compds. The polymeric product dkhloroacetylene. 5 reference*. VNJZ was a complex mixt. which probably contained CN and amino Chlorocarbona and chlorohydrocarboas; chloroprena. P. S. groups. C. M. Burn Bauchwitx (B. 1. du Pont de Nemours A Co., Inc., Wilmington. Study of bsterogenaous oxidation of n-butene* to 1.J-butsdiena -- Del.). Kirk-Otkmer Encjd. Ckem. Ttcknd.. 2nd Ed. 5, 215-31 hi tha presence ofsteam. I, I. Yukd'son and E. A. Boguslav- (1964XEttg). A review on the phys'. and chem. properties (in ski. 77. Lai. Kkim. Vysekomdtkni. Sotdin., Verenetksk. Uni*, eluding reactions with O, S, SO), NtO<, halogens, H, halides, and 1M4(3), 63-6(Ruj*). The effect cf steam concn. on oxidn. of a- bypohalou* acids and ester*, Diels-Alder addns. and dimeria- over newly developed catalysts (oxides of group VIII turns, free-radical reactions, and polymerirxtion), prepn. (from nwtiAwt by dements of group IV) was studied. The aw mate. . CjHi via monovinylacetylene, butadiene, butane* and butenes, rial was an industrial fraction of butene* with the compn. Hi " and 1 ^dkhioro-2-butcnc), industrial manuf., health and safety OJ.CiHtO.3, CH*0.6, C*Hh 1J. 1-CH32.6,2-0^63.4, and factors, and bomen and bomologs. 73references. VNJZ C4H41.6 snole-%. Oxidn. was effected in a continuous flow app. Chlorocarbona and chlorohydrocarbona: trichloroethylese. at 650* and* 1:2.5 diln. of the butenes with air over lml. cats- D. W. F. Hardie. Kirk-Otkmer Eneyci. Chem. Tteknel., 2nd Ed. hu (particle die 2-3 mm.) in a apart* tube (diam. 8 mm.). 5,183-95(1964XBng). A review on phys. and chem. properties. With an increase in butene-air-HiO mole ratio from 1:1.6 to -- manuf., ecooomk aspects, standards, handling, toxicity, and 1:15.8, the 1,3-butadiene (I) content of the contact gas increased use*. 53 references. VNJZ from 13.8 to 20.8 mole-% (bosk dry gas). Curve* were obtained Chlorocarbona and chlorohydrocarbons: methylen* chloride, showing the dependence of total butene conversion and I yield D. W. F. Hardie. Kirk-Otkmer Entycl. Ckem. Tteknel., 2nd Ed. per amt. of passed and decompd. butene on the steam concn. in 5, lll-19(1964XEng). A review on the phys. and chem. proper- tbe initial nuxt. From Ref. th., Kkim, 1966(4), Pt. II, Abstr. ^ ties, manuf., economic aspe-.U, standards and analysb, handling. No. 4N7. MVRK * toxicity, and uses. 40 references. VNJZ Chlorination reaction in the manufacture of hexaehlorobca- Chlorocarbona and chlorohydrocarbons: chloroform. D. W. gene. Jerzy Jaworski and Tadeuix Maxonakt (Kstedra Tec*- F. Hardie. Kirk-Otkmer Encjd. Ckem. Tttknol.. 2nd Ed. S. noL Chem. Org., Politeeb. Sbskm, Poland). Priemjd Ckem. 43 119-27(1964XEng). A review on phys. and chem. properties, (3), 93-4(1964XFo!). Continuous chlorination of o-dichlaro- manuf., ecooomk aspects, standards, analysis, handling, toxic- benzene in tbe gas phase (at 300-400*) and m the preseoce of a__ity. and uses. 25 references. VNJZ fixed bed catalyst was investigated. The catalyst used was in- Chlorocarbona and chlorohydrocarbona: tetrachloroethyleoe. expensive activated C, Carbopol Z, h> the form of irregular D. W. F. Hardie. Kirk-Otkmer Encjd. Ckem. Tctknti., 2nd fondles, about 5 mm. in dbm., with e density of 230 g./l. and a Ed. 5, 195-203(1964XEng). A review on the phys. and chem. 10 mrface area of 157.7 m.*/g. A uniform temp, gradient was properties, manuf., economk aspects, standards, handling, octal led when the upper part of the vertical pipe reactor was toxicity, and uses. 45 r;ferences. VNJZ filled with lets active catalyst from a previous charge. The J Chlorocarbona and chlorohydrocarbons; other chloroethanes. use d a partly deactivated catalyst resulted in a total absence of D. W. F. Hardie. Kirk-Otkmer Encjd. Ckem. Ttcknd., 2nd Ed. catalyst baking, even when its load was increased by 40%. The 5, 148-70(1964XEng). A review on the phys. and chem. prop- reaction product contained marc than 95% of bexachkrobeniene, erties, manuf., economic aspects, standards, handling, toxicity, bcades some pentachlorobensene. A schematic diagram of the and nses of 1,1- and 1,2-dkUoroethanc, 1,1,1- and 1,1,2-tri- cqujpcnent used b shown. Edward A. Ackermans chloroethane, 1,1,1,2- and 1.1.2,2-tetracblaroethaiie. penla- Chlorination of bobutytena to methallyi chloride. E. M. chloroethane, and hexachloroethanc. 101 references. VNJZ Melon, Xh. Z. Kotovieh, and D. K. Tolopko. Kkim, Prem,, Chlorocarbona and chlorohydrocarbona: caibon tetrachloride. Inform. Nank.-Ttkhn. Zb. 1965(4), 7-10(Ukrain). A 99.5% D. W. F. Hardie. Kirk-Otkmer Encjd. Ckem. Tctkuel., 2nd Ed. pure isobutylene (I) was prepd. by dehydration of lerf-BnOH 5,128-39(1964XEng). A review on the phys. and chem. proper- on AljO, at 350* with the 2 l./br. rate of I formation.* The ties, manuf., economk aspects, standard* and analysb, tuxi- catalyst was regenerated at 500-20* far 3 hrs. in a stream of hot _ city, and nses. 73 reference*. VNJZ air. Mixing 12 moles I with 1 mole Cl at 90-100* gave a mixt. * Synthesis of trialkylamlne-type extraction agents by the Hof- of products, which on rectification at 70-2* gav.e rarthahyi mans reaction. B. N. Laskorui, D. I. Skorovarov, and V. A. chloride (II). The fraction collected at 72-5* consisted of a 95:4 Semenov. Zk. Prikl, Kkim. 39(5), 1049-55( 19G0X Russ i- ratio of and dimcthylvinyl chloride which were difficult to Lab.- and bench-scale (~100 kg.) methods were described U* scp. A lower 1-0 molar ratio caused eddnl. chlorination of the prepn. of RjN, where R b Cr-Ca- RBr was prepd. by products and a higher ratio decreased the yield of II. At 90*, -- heating a mixt. of ROH, HBr or NaBr, and H&Q,. The org. a 62-72.6% yield of n was obtained. BMJW phase obtained, contg. 75-80% RBr end unreaeted ROH, iv.re Chlorocarbon* xnd chlorohydrocarbons: viryl chloride, treated with 8-34% NH.OH at 100-I80*/scvcral atm. Tlu D. W. F. Hardie. Kirh-Qlhmtr Encjcl, Ckem. Technol., 2nd Ed. yield of RiN increased with decreasing NHj-RBr ratio to 2--I 1 5,171-8( 1904XEng). A review on the phys. and chem. props- and with increasing temp. The yield was not affected by NH,OH ties, manuf., economk aspects, standards, handling, toxicity, concn. or size or R. The yield of resin began to increase at and uses, 38 reference*. VNJZ A R180*; the yield of solid product, probably RsNBr, increased CUorocarboa* and chlorohydrocarbons: methyl chloride, with decreasing temp. The starting conditions of ammnnntysre D. W. F. Hardie. Kirk-Otkmer Encjd, Ckrm. Tteknel., 2nd Ed. become milder as the batch sire increased, because the reaction re 5, 100-11( ,9G4XEm). A review on the phys. and chem. prap ciothcrmie and a large butch provided a larger propnctimi of 1I0 erties, manuf., economic aspects, standards, analysb, handling, required heat tlian a small batch under simiLu ciMMlitimre. A toxicity. aad uses. 43 references. VNIZ tvokal final nrndwt of a f-C. msw. nwhiwi w.M ka.Tii. R&S 028189 R&S 028190 Vtil. (il', 1%6 4509 UU -Toxicology ami Air ToUution 4510 il<itin>Kl<i)>iii To*;; viid. with Cn) in ]il rfi>f umpiring O muiir Akiul. Vnl.. Rr.ilislava). EnJivtiniilugt 7WI). 151*5(1005) hypirb.irii-i-mith'iini'.. Willi 7 , Ob priMiit m (In- Mtppliiti O. (ling). Allil i^,lliim-y.iii.ili, .tilinini-li rul in single duns of tiu- CO feu* ilimiu.ilixl nurl) IfeH'i .ii fj'l 4' feluii purl1 O fe'as 2 lu 4 mg. d.piissid significantly tin r.uti.,i.-liin uptake Ly nit Jri-,piriil. Of 'll pjtKtit' with ciml Ji' |itjv)mn(. flu respiration thyroids. Thu administration nl al'yl 's*.tin*.male to rats fur )i O at '1 aim. pressure led to recovery!no fatalities). All pa- t>l days, in tli-*' mtrispondiitg approx. t.t tliv tut.il content n( tmits recuvirnl consciousness 30-90 min. aftit inhalation of O 0 mustard nils in nbbagr, canin' changes ill the tliyruid similar to 1-- undvr pressure bigan. Of 7U other severely coal-gassed patienttsh,ose follofeing cabhajr finding, RCFN only 3 did nut recover. Thi- results demonstrated that hyper The physiological properties of aerosol propellant*. Hens baric O should Ik administered a* mhjii ms jmssible in CO poison KuebliT (Sprulituluiik G.iii.b.ll., KenifehiiTi, Gir.). Aerosol ing. Liaia are givm on 1 patirtii feitlt barbiturate putxnumg who Afe 9(4), 44, 47 K. .VI, Ut)*llHMi4ji Eng). A discussion of the recuvired frum respiratory and Cardiovascular depression under_ physiul. limits tor many aerosol propellants vaj presented. hyperbaric O alien other methods failed. Other rejmrts indicate Rats. mice, and guinea pigs acre eximsed for 2 hrs. daily for 100 that there arc no advantages iri giving O at more llian.2 attns. days to t>.5. 1.5. and 5.11'i vol. of tile propellants, vinyl eh'oridc pressure. Ar higher pressures, toxic effects of O appear, per (I), ar.d mixta. of trichlorofluoromethane (II) and dichldrodi* haps resulting from the presence of CO in the blood. fluoromethane(III)(50.5i)aml 10:90). The animals showed no W. C. Tobic reactions to 'be mixtt. at any concn. or with pure I to 1.5%. Diagnosis of salt poisoning in *anim*l*. M. Bohosiewic* b With 5% I tin- animals first showed increased mobility which was (Wyzsza Szkola Rolnicza, Wroclaw, Poland). Zessyty Nauk. then gradnal.y reduced. Upon autopsy no histol. damage was Wyxtztj Sikoly Rolniatj Wroclaw!v. Ife/rrynarsa 11(42), 3--43 seen. Mice under a plastic cover were sprayed with a shellac- (19C2XPol). Administration of high NaCl doses (3-4 g./kg.) based bairspray with 1, II, and 111 propeiiants for 30 sec. daily caused acute intoxication in mice and pigs. XaCl poisoning was for 5 weeks at a distance of 20-25 cm. There were no histol. noted when Xa* values in the brain and liver exceeded 150 mg. changes in the lungs. The thermal decompn. wasdetd, at 1000*. % and those of Cl" 180 mg. % in brain, 70 mg. % in muscles,-- One g. I yielded 39.6 mg. CO, 11 mg. COCl,, and 102 mg. HClj and 250 mg. % in liver. "Tie loss of water in brain, muscles, 1 g. 11(1.5.7.0,and94); ' g. 111(1.5,2.4,79); 1 g. sym. dicbloro- and liver amounted in mict to 3.8, 7.6. and t2%. resp. In tetraflnorocthane (0.8. 12.0, 59); and 1 g. methylene chloride pigs this decrease in brain, muscles, and m liver amounted to (15.2,18.0,81). BKJN 4.5, 0.2, and 8.7%. K. Belzecka Concentration on molecular aieves at preliminary determina Toridty of the oleander leave*. Symptom*, pathological tion of trace components of min* air. Jerzy Mizycruk (Clown/ anatomical damage*, and method! of glucoeide identification. Inst. Gomictwa, Katowice, Poland). Ckem. Anal, (Warsaw) C. E. Eliakix. E. C. Eliakis, and A. S. Coutselinis. Ann. 9(4), 671-82(1964). Trice components of mine air, such as Jltd. Letalt Criminol., Police Sci. Toxicol. 41( July-Aug.), C|Hi, C,H,. and a-CJfit. were coned, on a mol. sieve of 3 A. 367-88(1961XFr). Decoctions (10:150) c." oleander leaves, type at 0* and 30* and retention times were measured. Prod cootg. 3 X 10'* g. of neriin and 4.5 X 10~* f. of oleandrin, were ucts of desorption at 300* were analyzed in a gas chromatograph used. Rf values of 0.65-0.70 lor neriin and 0.06 for deendrin -- with a conductometric detector. In some cases addnl. concn. were found by means of paper chromatography (Whatman No. 1, was used. The method makes it possible to increase the sensi ascending, undimensional, 3:1:3 EtOAc-HOAc-HjO). With tivity of the detit. of C,H, CiHi, and C,H, 10-100 times. _ The the same method, very similar values were found for difitoxin, results of the detn. of traces of gases in a sample of mine air are tanatoside, and other glucosides. No abortive effect could be given. The effect of concn. can be estd. from the retention vols. detected on pregnant rats. Twenty ml. of decoction (conod. Z. Kurtyka to /) resulted in the appearance of toxic symptoms in rats after " Permeability of newborn rat akin to a volatile hydrocarbon, 20*60 min. The oleander components seem to affect the central "C-labeled p-cymeaa. Guillaume Valette, Yves Cohen, mud aMmcrvous system, esp. parti related to the telencephalon and Jacques Wtpierre (Fac. PLarm., Paris). Compi. Rend. Sat. ^Berebclium, the symptoms resembling those of decerebration Biot. 158(5), 950-4(1964XFr). The ejmpd. readily diffused ^^paralysis. according to Sherrington, also displaying tendency to through the baMess shin and was detected in various organa. A total or partial disintegration of cereoellum. In rats, which _ special app, eras used to prevent my inhalation of the vapor which received 3 ml. of decoction intraperitoneally 9 times every other might invalidate the findings. Since the hair follicles had not day, congestion of the parencLymatcsic organs took place. yet been formed, they are not indispcnsible for penetration of a Damage to kidneys, liver, heart, and peribronchial inflammatory volatile hydrocarbon. L. E. Gflaou congestion and atelectasis of the lungs was drtd. microscopically. Flu* gas from aUnts manufacturing synthetic fatty adds and From CZ 1963(24), 10176. MWCR alcohols. F. I. Dubrovskaya (F. F. Erisman Scj.-Res. Inst. Os* of the chicken embryo in the assay of aflatoxin toxicity. * Hvg.. Moscow). Giptna i Sanit. 36(1), 7-10(1901XRuss). M. Jacqueline Vcrrett, Jean Pierre Maniac, and Joseph Mc Results are reported on the investigation of 1252 air srmples Laughlin Jr. (Food ft Drug Admin., Washington, D.C.). (580 in March/April and 672 in June/July) collected 250-5000 J. Astoe. Ofie. At*. Chemists 4, (O). 1003-6(1964). Preliminary u. from factories manufg. fatty adds and fatty aka. In all results of an investigation of lire general systemic toxicity of samples in the spring, hydrocarbons (max. 36 mg./m.*) were aflatoxin (1) in chicken embryos are reported. The studies are detected; fatty adds, h 34% of the samples (same max.); and not complete enough to verity if any 1 produces any specific unsatd. hydrocarbons, <a half the samples (max. 13 mg./m.'). pathoi. lesion in the embryo. Injections of test solns., in pro In the summer, 70% of the samples contained hydrocarbons pylene glycol vehicle, were made, before incubation, in fertile (max. 63-90 mg./m.*), 52% contained fatty adds, and 66% white Leghorn eggs either by way of the yolk or air cell. De contained unsaid, hydrocarbons. Acetone and formaldehyde velopment of the embryo was observed for the full 21-day in were found in only a few samples. From CZ 1962(47), 17163. cubation. Injection of solns. of pure I Bi and Gi, and of cats. , MRCR of I-producing mold cultures indicated that the chicken embryo 1 Maximum permluible concentration of chloropren* in the was sensitive to these compds. The relation of toxicity of the atmosphere. A. V. Mnatsakanyan (N. B. Akopyan Inst. samples to mortality at time of hatching, exhibited a dose re Epidemiol, and Hyg., Erevan). Gipma i Sanit, 29(9), 13-18 sponse. Exts. of I-free peanut products were nontoxie to the (1964 X Russ). A concn. of 0.22 mg. chloropreue/m.* was the embryo. Addn. of I Bi to such uncontaminated exts. produced threshold eouca. for decreasing tfce sulfhydryl concn. in twain the expected toxicity. Injection of exts. from contaminated -- homogenates and increasing adenosint-triphosphatase activity peanut product* resulted in a toxic response that con-elated well in the livers of tats exposed constantly for 60 days; 0.08 mg./m'. with that obtained by injection of pure I Bi mins, at same dose is considered a proper max. John Howe Scott levels, and in most instances the ehem. analysis was confirmed. Effect of dichlorebuten* on the olfectory organs and ocular The presence of I Gi, Bj, and G, had no apparent effect on the analysers. G. V. Demyan (Med. Inst., Erevan). /*- A had. toxicity due to 1 Bi at the levels at which they occurred in the Rank Arm. SSR, Biot. Kinki 17(7), 101-4(1964XRuss). The particular samples tested. Sepn. of 1 Bi from contaminated 9 threshold concn. for a dichlorot -ar.e (I) effect on the olfactory exts. by thin-layer chromatography, and its subsequent -elution analysors was investigated with 15 patients and was equal to from the plates and injection into the eggs, confirms! that the 0.34 mg./m.* Effect of I oo the visual center ins examd, on toxicity of these exts. was due primarily to their IB, content. 3 patients. The results indicated that in some eases 024 mg./ H. A. Lepper m.1 of I produced harmful effects oo dark adaptation. A concn. Electrophoretic and chemical studiei on eerumi of swine follow*_ of 0.34 mg./m.' of I in air was considered harmful. kg the feeding ol toxic peanut meal. E. Annau, A. H. Corner, M. Charmandarian 5. E. Magwood, and K. Jericho (Animal Diseases Res. Inst., Effects of inorganic foorides on animals. J. W. Suttie _ Hull). Can. J. Comp. Med. Vti.Stt. 28(ll).264*8(1964XEng). (Univ. of Wisconsin, Madison). J. Air Pollution Control Assoc. The consumption of toxic peanut meal by swine leads to marked 14(11), 461-4, 48(XlU64XEng). F~ toxicity in cattle can re alterations in their electrophoretic serum patterns. Expts. car sult from the ingestion of forage contaminated by industrial ried out by chein. assays, moving boundary electrophoresis, k processes. Cattle are affected when F~ levels in the compact and starch-gel electrophoresis showed a relative decrease in the bone exceed 5500 ppm. Marginal toxic effects arc noted in albumin, a,-, at-, and fl-globulins, while -pflobulin appeared to animals with F~ concn*. in these bunes of 4500-5500 ppm. be considerably increased. Rudolph Seidell The concn. of F" an forage that can produce these coocna. hi Goitrogenic activity of aByl laothlocyanate. A widespread utnfil mnefant fell P.--l I ,n,^ ,*4 VtVhv Ct*U ICwIhL* the skdeton k-.*l _ dekpe-nds- no a no. - ... of ff-a--c--t:ovrs-. A-h---q-ualit-y--s--t-a--n-d- -a--rdSs