Document QJa93nkjG869kNmo8kygq204R

General Office* Mr. H. G. Utesinger * General Qffiees Mo. Regina Brencick-SRe Or. R. a. Hatton-1 TOO J Mr. R. 0, Minteer-GO Mr. 7. P. oanda-00 Mr, W. A. Wllklnson- Deoember 29, 19'jO Organic bicivir: TOXICITY REPORTS ON OS-95 On February 2o, Mr. Oarrott forwarded a copy of the screening toxielty data on OS-95. As you know, olnea that tine w have liad some additional work done and copies of these reports are attached. The report dated October 20 Is a repeat of two parts of the procedures done originally) that is, skin absorption or skin penotration lethal dose and skin irritation potential. The data confirms the results of the original screening studies. (tore recently we have received a report on a limited study to determine the toxielty of decomposition produots of the fluid, A summary of this work is quoted belowi Croup A Exposure to Moderate Mist (3ix Hours Total) All animals survived the schedule of six, one hour ex* posures spread over a period of two weeks. Copious nasal discharge, salivation, lethargy, and moderate weakness developed. The fog oaused considerable inflammation and discomfort but the cumulative effeot was not lothal. "group Bi ' ' " avy Concentration of Mist (Fifteen No deaths resulted from fifteen minutes exposure to a heavy concentration of fog. There was irritation but the animals were not in danger of collapse. Oroup Ci Exposure to Heavy Concentration of Mist (One Hour Total) Collapse and near collapse developed in the latter stages of the one hour exposure. No deaths resulted. The animals were moving about in fifteen to forty-five minutes after exposure, weakness was evident for several days." On Dooeubor 11, Sr. Kelly sent you a memo with an attachment en titled "OS-95 Toxielty Statement". Copies of this correspondence are attached to those who were not copied in originally. MONS 098069 Mr. II. otu Litzoint$r--Pt;# 2--Deoembor 29. 1950 This BtQtomont was prepared by Dr. Solly and mo after you In formed us that thoro woro ecmo plant workers viho had quite continuous olein contact with Fydraul F-9, The dogree of ex posure which we talked about was comparable to that of an auto mobile mechanic spending c hours a day tearing down, repairing and reasoombllng automobile engines. It was and Is my opinion that such a degree of exposure to 08-95 could lead to akin difficulties In workers. We would not expect that this would be of tho dkydrol 500 type but rather a combination of the de fatting action oomparable to that with paint thlnners and some absorption leading to production or development of ehloraene. As a result of our conversations and Dr. Kelly's suggested 03-95 toxicity statement, I believe you have Included In your report turning this produot over to dales, a statement that emphasis must be given to avoldanoe of skin contact, with this I highly agree. Mr. Sands has slnoe oalled ms to discuss the implications or this roconmendatlon. I told Mr. Sands that our eonoom about the use of OS-95 le In line with our recent thinking concerning all fluids Incorporating Aroolors in the formulations. The Medical Department doea not recommend any stronger precautionary statement on labela for 03-95 than has bean rooouaended recently for other fluids containing the Aroolors or. In fact, for the Aroclore alone. To do so would add to ths inconsistency which appears to have developed in moat of our recent thinking and opinions oonoamlng hydraulic fluids. As you are well aware, the precautions which we In the Medical Department recommend in an effort to prevent difficulties in the use cf our products must be baaed on an estimate of the exposures of tho poople using and handling the fluids. I personally have never soon a diecasting machine. Dr. Kelly has aeon one or two small ones at North American Aviation. Prom ths verbal descrip tions of aueh equipment provided us by Sales and Development personnel, it would appear that prolonged continuous skin eontaet could be avoided. This was what we had expeoted with the 3kydrol fluid only to loam that aueh was not the oase in every instance. As we became better educated or better Informed as to ths degree of exposures, subsequent opinions must be related to these ex posures. In summery, ws would not recommend that any of our fluids be handled sa If they were non-taxle" petroleum lubricating oil. The fact that this may have boon the ease for a few people with Fydraul F-9 and no difficulties have been experienced does not lead us to oondone this practice. For this reason we do not believe that ths sales approach in attempting to substitute 08-95 for Fydraul y-9 should be that "if you handle 08-95 the way you have been handling Fydraul P-9, you will have no difficulties". We do think that if potential customers are told that akin 0ontact must bo avoided In accordance with our recommendation In the pact MUNS 098070 Mr. H. btu Utealntfor'-Fage 2---Doewbov 29 19&ti that such contact be avoided with Pydraul ?-`3, there ahould bo no ocrloua problone. arwidh AttAOhMAtl Reoelve cop/ of report blmer t. Wheeler HONS 098071