Document QJ68vMQe4rv1w8JgNR2dMxjDo

HISTORICAL PERSPECTIVE ON INTER-INDUSTRY VINYL CHLORIDE STUDY 1960-1963 1967 1971 Report published documenting anesthetic effects in animals and humans and liver injury in animals from chronic exposure. ClubloiUj O-f2 j Acroosteolysis reported in humans exposed to high levels of VCM. caiA zb'cLy Carcinogenicity of VCM discovered in animals, including angiosarcoma of the liver. /Are./- 1973 CMA sponsors Tabershaw-Cooper Associates to conduct an epidemiologic study of 8,384 vinyl chloride workers from 34 plants. 1974 1974 First reports of angiosarcoma of the liver cases in VCM workers. 8F& af- K&rbscJzy Tabershaw-Cooper report preliminary results confirming high risk of angiosarcoma of the liver and suggesting excess cancers of respiratory system, brain and lymphoma. RESTRICTED FOR USE WITHIN DOW AND DOW SUBSIDIARIES R&S 142861 HISTORICAL PERSPECTIVE ON INTER INDUSTRY VINYL CHLORIDE STUDY (cont.) 1974 OSHA holds hearings and revises PEL down to 1 ppm. 1981 1986 hJo t&uj resell published 5" Cooper expands original epidemiology study to include 10,173 workers from 37 plants-- reports show angiosarcoma and brain cancer to be in excess through 1972. &\v)vpv^v*4wJ2 /Itj xA EHA updates inter-industiy study with follow-up through 1982-- reports angiosarcoma, brain cancer and emphysema to be in excess--no excess respiratory cancer or lymphoma/leukemia. 1991 EHA study is published. 1993 CMA letter to the editor and EHA response are published clarifying the brain cancer and emphysema findings. R&S 142862 1994 MtW {acx v<- (O foOird o >' * ` ^fxPtlcKAl \jJOrbxt$ GGB 3/15/94 ___________ / 0 y^xifz Icvfer. CMA Vinyl Chloride Research Coordinators meet to discuss updating study. RESTRICTED FOR USE WITHIN DOW ------------------------- AND DOW SUBSIDIARIES `The study carried out by Environmental Health Associates on behalf of the U.S. Chemical Manufacturers Association is the largest and most informative investigation thus far undertaken." Sir Richard Doll Scand J Work Enviorn Health 1988; 14:61-78 RESTRICTED FOR USE WITHIN DOW AND DOW SUBSIDIARIES R&S 142863 BENEFITS OF UPDATING INTER INDUSTRY STUDY OF VINYL CHLORIDE WORKERS Goodwill - Demonstrates to workers, community residents, customers, and other audiences our collective commitment to characterize any health risks posed by operating VCM/ PVC processes. l$V~f- Scientific Knowledge - Refines the estimate of the number of cases of human angiosarcoma of the liver (ASL) associated with operating VCM plants in the pre-1972 era. Contributes ASL cases to the international ^jegist^> - Helps to resolve unanswered questions about alleged links to cancers of the brain, lung, and hematopoeitic system as well as address other causes of death such as emphysema. Litigation Defense - VCM/PVC manufacturers continue to face toxic tort litigation alleging numerous types of cancer are related to VCM/PVC employment. This type of research is useful in defending such litigation. R&S 142864 GGQ 3/15/94 RESTRICTED FOR USE WITHIN DOW AND DOW SUBSIDIARIES BENEFITS OF UPDATING INTER-INDUSTRY STUDY OF VINYL CHLORIDE WORKERS (cont.) Chlorine Issue - VCM/PVC continue to be a part of the general debate on health and environmental impacts of chlorinated organics. This type of research serves a valuable role in helping to debate the issues on the basis of good science. R&S 142865 GGB 3/15/94 RESTRICTED FOR USE WITHIN DOW AND DOW SUBSIDIARIES FUTURE VCM/FVC RESEARCH OPTIONS What has been the impact of the 1974 PEL reduction on the incidence of ASL and other cancers among VCM/PVC industry workers? Are there biomarkers of VCM exposure which could be used to better quantify worker exposures for future research into dose-response relationships? Besides cancer, are there other health effects one should be concerned about (i.e., fertility reproductive and developmental effects, endocrine effects, immune system, nervous system, other)? With recent allegations of dioxin formation in the EDC/VCM process, are there additional health research studies needed? RESTRICTED FOR USE WITHIN DOW AND DOW SUBSIDIARIES R&S 142866