Document OzwQaX42BgXNDBYaGabK4aYZp

~! : : School of Medicine : : Community Medicine : : C8 ~ PaRe'1 of 12 .4.[ 22!> 387 3 1r~dex = Ir~r~a~ ~tap ~ wy'tt Direct~ ~ ~ tt~~ta~t School of Medicine S_ite-Map C8 Home What is C8 What's New? C8 Health Project Settlement Details Brookmar Project Team Science Panel WVU Project Team C8 Health Project Results Contact Us Other Links Department Home SoM Home Search : ',_1 Department ,:~: Health Sciences Center 0 WVU [ C8 Home > C8 Results > Other Clinical Lab Values Print C8 Health Project Results C8 and Other Laboratory Values The WVU website is a communication vehicle to depict associations or their public use. These tables and graphs show many comparisons between tat corresponding population serum PFOA (C8) levels . When it appears that ther relationship between serum C8 and a clinical laboratory value, the mear relationship still requires thought and discussion . Some of the relationships, wP weak and not likely to be important. Several are strong, interesting and potential and none of them can be taken to show an etiologic (cause and effect) relatic absence without more work . When it comes to causes, scientists interpret these data with deference to additional work that needs to be done . These data concerning associations are for public use. They will receivi collaborative work in peer review format. We hope they prompt public ci suggestions of interested scientists . The results summarized on this page include differences in C8 values based on abnormal clinical laboratory results (normal / abnormal laboratory cutoff values c referenced on each graph), and for differences on clinical laboratory values b. deciles (for a summary of C8 decile cutoffs, please click here ). R Download Abobe Reader Other Laboratory Values ABCDEFGHIJKLMNOPQRSTUVWXYZ Alpha-Fetoprotein Tumor Marker (Serum) Descri tR ion of AFP (39 KB) Serum C8 By AFP for Participants 1-2 Years of Age (24 KB) Serum C8 By AFP for Participants >= 3 Years of Age (24 KB) 0 C8 Population Deciles & Alpha-Fetoprotein Tumor Marker (35 KB) Albumin (Serum) Description of Albumin (37 KB) . Serum C8 By Aiburnin (Serum)Lev_els ln Participants ~18. Years Of Ag e (2~ . Serum C8 By Albumin (SerumL)evels In Participants >=18 Years Of Age (: s C8 Population Deciles & Albumin (37 KB) Alkaline Phosphatase (Serum) Description of Alkaline Phosphatase (4 KB) Serum_ C8 Br Alkaii ne Phosphatase Levels in Partic ipants 1-3 Years of Ag.E Serum C8 By Alkaline Phosphatase Levels in Participants 4- 6Years of Ag.E Serum C8 By Alkaline Phosphatase Levels in Participants 7-9Years ofAct( Serum C8 By Alkaline Phosphatase Levels in Participants 10-12 Years of f Serum C8 By Alkaline Phosphatase Levels in Participants 13-15 Years of f http ://www .hsc .wvu.edu/som/emed/c8/results/otherLaborato :~.ryValues/index .asp 1/8/2009 WVU : : School ofMedicine : : Community Medicine : : C8 Papea2 of 12 e Serum C8 By Alkaline Phosphatase Levels in Participants 16-17 Years of f " Serum C8 By Alkaline PhosDhatase Levels in Paicpans 18-59 Years of E " Serum C8 By Alkaline Phosphatase Levels in Participants >=60 Years of A " C8 Population Deciles & Alkaline Phosphatase (36 KB) Alanine Transaminase (ALT or SGPT) " Description of ALT (38 KB) " Serum C8 By Alani_ne Transaminase Levels In Pa rticipants 1-3 Years of Ag " Serum C8 By Alanine Transaminase Levels In Participants 4-6 Years of Ag " Serum C8 By Alanine Transaminase Levels In Participants 7-9 Years of Ag " Serum C8 By Alanine Transaminase Levels !n Participants 10-11 Years KB) " Serum C8 By Alanine Transaminase Levels In Participants 12-13 Years KB) " Serum C8 By Alanine Transaminase Levels (n Participants 14-15 Years KB) " Serum C8 By Alanine Transaminase Levels In Participants 16-19 Years KB) " Serum C8 By Alanine Transaminase Levels In Participants >=20 Years of j " C8 Populatio n Deciles & Alanine Transaminase (36 KB) Antinuclear Antibodies (Direct) " Description of Antinuclear Antibodies (40 KB) " Serum C8 By Antinuclear Antibody Levels In All Participants (Normal <100 KB) " Serum C8 By Antinuclear Antibody Levels En All Participants (Normal <200 KB) " C8 Population Deciles & Antinuclear Antibodies (38 KB) Aspartate Aminotransferase (AST or SGOT) " Description of AST (40 KB) o Serum C8 By AST Levels In Participants 2-17 Years of Age (23 KB) ". Serum C8 By AST Levels In Participants 18-59 Years of Age (23 KB) " Serum C8 By AST Levels In Participants >=60 Years of Age (23 KB) " C8 Population Deciles & Aspartate Aminotransferase (37 KB) Basophils (Absolute) " Description of Basophils (as part of Blood Differential) (39 KB) " Serum C8 By Basophil (Absolute) Levels In Participants <18 Years Of Age " Serum C8 By Basophil (Absolute) Levels In Participants >=18 Years Of Ag. " C8 Population Deciles & Basophils (Absolute) (38 KB) Basophiis (Percent) " Description of Basophils (as part of Blood Differential) (39 KB) " Serum C8 By Percent Basophil Levels In Participants <18 Years Of Age (2: " Serum C8 By Percent Basophil Levels in Participants >=18 Years Of Age ( " C8 Population Deciles & Basophils (Percent) (37 KB) Bifirubin, Direct " Description of Bilirubin (40 KB) e Serum C8 By Bifirubin (Direct) Levels !n Participants <18 Years Of Age (23 " Serum C8 By Bilirubin (Direct) Levels In Participants >=18 Years Of Age (2 " C8 Papulation Deciles & Bilirubin. Direct (37 KB) http ://www.hsc .wvu .edu/som/cmed/c8/results/otherLaboratoryValues/index.asp 1/8/2009 WVU : : School of Medicine : : Community Medicine : : C8 P+-33 of 12 Bitirubin, Total " Description of Bilirubin (40 KB) " Serum C8 By Biliru bin (Total) Levels In Participants <18 Years Of Age (23 " Serum C8. ._By_Bilirubin_(Totaf)_Levels In_ Participants -18 Years Of Age (2 ; " C8 PoWlation Deciles &Bilirubin, Total(37 KB) Blood Urea Nitrogen (BUN) " Description of BUN (42 KB) " Serum C8 By BUN Levels In Participants <12 Years Of Age (23 KB) " Serum C8 By BUN Levels in Participants >=12 And <18 Years Of Age (23 " Serum C8 By BUN Levels In Participants >=18 And <60 Years OAf ge (23 " Serum C8 By BUN Levels In Participants >=60 Years Of Age (23 KB) " C8 Population Deciles & Blood Urea Nitrogen (36 KB) BUN: Creatinine (Ratio) " Description of BUN: Creatinine " Serum C8 By BUN:Creatinine (Ratio) Levels In Participants <18 Years Of E Serum C8 By BUN:Creatinine (Ratio Levels In_Partici ap nts >-8 Years O KB) " C8 Population Decites & BUN: Creatinine (37 KB) Calcium (Serum) " Description of Serum Calcium (40 KB) 0 Serum C8 By Calcium (Serum) Levels !n Participants <18 Years Of e(2: " Serum C8 By Calcium (Serum) Levels 6n Participants >=18 Years Of Age (: CS Population Deci[es & Calcium (37 KB) Cancer Antigen (CA-125) " Description of CA-125 (41 KB) " Serum C8 By Cancer Antigen (CA-125) Levels In Participants <18 Years O KB) " Serum C8 By Cancer Antigen (CA-125) Levels !n Participants >=18 Years KB) " C8 Population Deciles & Cancer Antigen (36 KB) Carcinoembryonic Antigen (CEA) " Description of CEA (39KB) " Serum C8 By Ca rcinoembrvonic Antigen (CEA) Levels In Smoking Partic~ KB) " Serum C8 By Carcinoembryonic Antigen (CEA) Levels In Non-smoking PaE (21 KB) " C8 Pppuiation Decil.es & C_arcinoernt~onic Antigen (34 KB) Chloride (Serum) " Description of Chlori de (35 KB) Serum C8 By Chloride (Serum) Levels In Participants <18 Years Of Age (2 " Serum C8 By Chloride (Serum) Levels In Participants >=18 Years Of Age ( " C8 Population Deciles & Chloride (38 KB) Cholesterol, Total http://www.hsc.wvu.edu/som/cmed/c8/results/otherLaboratoryValues/index .asp 1/8/2009 ., WVU : : School of Medicine : : Community Medicine : : C8 Pgge 4 of 12 " Description of Total Chotesterol (46 KB) " Serum C8 By Cholesterol Levels In Participants >=2 And <20 Years Of Aoc " Serum C8 By Cholesterol Levels In Participants >=20 Years Of Ac ,Le (23 KE " C8 Population Deciles & Cholesterol (36 KB) Cortisol " Description of Cortisol (38 KB) " Seru m C8 By Cortisol (AM Blood Draw Levels In Participants (61 KB) " Serum C8 By Cortisol (PM Blood Draw) Levels In Participants (61 KB) s C8 Population Deciles & Cortisol (37 KB) C-Reactive Protein (CRP) " Description of CRP (40 KB) o Serum C8 By C-Reactive Protein (CRP) Levels In Participants <18 Years C KB) " Serum C8 Bv C-Reactive Protein (CRP) Levels In Participants >-18 Years KB) " C8 Population Deciles & C-Reactive Protein (38 KB) Creatinine (Serum) o Description of S_erumCreatinine (41 KB) e Serum C8 Bv Creatinine (Serum) Levels In Participants <18 Years Of Age o Serum C8 By Creatinine (Serum) Levels In Participants >-18 And <6E}Yea (23 KB) " Serum C8 By Creatinine (Serum) Levels In Participants >-60 Years Of AgE " C8 Population Deciles & Creatinine (36 KB) Eosinophil " uescnnitnn or rncinnnnarc i ac r, aft of Dr--A Diff_ erential' (43 KB} " Serum C8 By Eosinophit Levels In Participants <18 Years Of Age (23 KB) " Serum C8 By Eosinophit Levels In Participants >-18 Years Of Age (23 KB) " C8 Population Deciles & Eosinorhit (37 KB)} Eosinophil (Absolute) o aescription of Absolute Eosinophils (40 KB) " Serum C8 By Eosinophil (Absolute) Levets In Participants <18 Years Of Ag " Serum C8 by EOSinophil (Absolute) Levels In Participants >-18 Years Of A " C8 Population DecEles & Eosinouhil (Absolute} (38 KB) Estradiof " Description of Estradiol (40 KB) " Serurn C8 By Estradiol Levels In Females (15 Age Group~ (82 KB) " Serum C8 By Estradiol Levels In Females Stratified By Age-Group (31 KB) " Serum C8 By EstradFot Levels In Males (6 Age Groups) (31 KB) "" SCe8rPuompcCxl8atBEyonEDsetcriadlieost_&LeEvsetlrasdIinolM(a3l6esKBSt)ratified By Age Group (25 KB) Folates (Folic Acid ; Serum) " Description of Folic Acid (38 KB) " Serum C8 By Folic Acid (Serum} Levels In Participants <18 Years Of Age ( " Serum C8 By Folic Acid (Seruml Levels In Participants >-18 Years Of Age " C8 Population Deci(es & Folates (38 KB) http ://www.hsc .wvu .edu/som/cmed/c8/results/otherLaboratoryValues/index .asp 1/8/2009 WVU : : School ofMedicine : : Community Medicine : : C8 PTge 5 of 12 Free Testosterone (Direct) " Description of Free Testoterone (Direct) (39 KB) " Serum C8 By Testosterone Levels In Females (6 Age Groups) (30 KB) " Serum C8 ~Testosterone Levels in Adult Females Stratified b~Age-Grou " Serum C8 By Testosterone Levels In Males 6Age Groups) (31 KB) " Serum C8 By Testosterone Levels [n Adult Males Stratified By Age-Group. i " C8 Population Decifes & Free Testosterone (36 KB) Free Thyroxine Index " Serum C8 By Free Thvroxine Index Levels ln Participants <18 Years Of Ag " Serum C8 By Free Thyroxine lndex Levels In Participants >= 18 Years Of A " C8 Population Deciles & Free Thyroxine index (37 KB) Gamma-glutamyl Transpeptidase (GGT) " Description of GGT (40 KB) " Serum C8 By GGT Levels In Participants <18 Years Of Age (23 KB) " Serum .C8 By_GGT Levels In Partici .a nts >=18 Years Of Age (23 KB) " C8 Population Deciies & Gam ma-g(utam ly Transpeptidase (35 KB) Globulin, Total " Description of Globulin " Serum C8 By Globulin (Total) Levels In Participants <18 Years Of Age (23 " Serum C8 By Globulin (Total) Levels En Participants >=18 Years O1F Age (2: " C8 Population Deciles & Globulin Total (36 KB) Glucose (Serum) " Description of Serum Glucose (44 KB) " Serum C8 Bv Gtucose Levels !n Fasting Participants <18 Years Of Age (22 Serum C8 By Glucose Levels In Fasting Participants >=18 Years Of Age (2 " C8 Population Deciles & Glucose (36 KB) High Density Lipoprotein (HDL) Cholesterol " Description of HDL (40 KB) " Seru m C8 By HDL Cholesterol Levels !n Partici ants >-2 And <20 Years C KB) " Serum C8 By HDL Cholesterol Levels In Participants >-20 Years Of Age (~ " C8 Population Deciles & High DensityLipoprotein (HDL) Cholesterol. (37 Kl Hematocrit " Description of Hematocrit (36 KB) " Serum-C8 By_Hem atoc rit Levels In Participants _> =2 And <10 Years Of Age " Serum C8 Bv Hematocrit Levels In Participants >=10 And <18 Years Of Ag " Serum C8 By Hematocrit Levels In Participants >=18 Years Of Age (23 KB " C8 Populatjon Deciles & Hematocrit (35 KB) Hemoglobin " Descri tion of Hemoglobin (37 KB) " Serum C8 By Hemoaiobin Levels In Participants >-2 And <10 Years Of Ag " Serum C8 By Hemoglobin Levels En Participants >-10 And <18 Years Of A " Serum C8 By Hemoglobin Levels In Participants >-18 Years Of Age (23 Ki http://www.hsc .wvu.edu/som/cmed/c8/results/otherLaboratoryValues/index.asp 1/8/2009 WVU : : School of Medicine : : Community Medicine : : C8 Pa'ge 6 of 12 " C8 Population_Deci(es & Hemoglobin (36 KB) Immunoglobulin A (IgA ; Serum) " Description offgA-(as part of Antibody Tests) (99 KB) " Serum C8 By Immunoglobutin A (Serum)Levels In Participants >--1 And Age (23 KB) " Serum C8 By Immunog(obulin A (Serum) Levels In Participants >==4 And < Age (23 KB) " Serum C8 By Immunoglobufin A (Serum) Levels In Participants >--7 And <- Ace (23 KB) " Serum C8 By Immunogtobufin A (Serum) Levels In Participants >=10 And " Of Age (23 KB) " Serum C8 Bv Immunogfobufin A (Serum) Levels In Participants >=12 And " Of Age (23 KB) " Serum C8 By Immunogfobulin A (Serum) Levels In Participants >=14 And ~ Of Age (23 KB) " Serum C8 By Immunoglobulin A (Serum) Levels In Participants >-16 And " A Ofge (23 KB) o Serum C8 Bv Immunoglobulin A (Serum) Levels in Participants >=20 (23 K " Serum C8 By lmmunoglobulin A (lgA) Levels !n Females Stratified -By Age- KB) " Serum C8 By Immunogtobulin A (IgA) Levels In Males Stratified B Age-Gr o CS Population Deciles & Immunogfobulin A (37 KB) Immunoglobulin E (IgE ; Total) Description of IgE (as part of Antibody TesUs (99 KB) Serum C8~ fmmunogtobulin E .(TotallLevels In Participants >=1 And <5' Age (2K3B) " Serum C8 By lmmunoglobulin E (Total) Levels In Participants >-5 And <11 Age (23 KB) o Serum C8 By_Immu noglobulin E_jota0 Levels in Participants >_=1'I And <1 Age (23 KB) " Serum C8 By (mmunoqlobulin E (Total) Levels In Participants >=16 Years I KB) " Serum C8 ft Immunoglobin E (igE) Levels in Females Stratified By Age-G KB) 0 Serum C8 By Immunoglobin E (IgE) Levels In Males Stratified Bv Aae-GroE " C8 Population Decites & fmmunoglobulin E (37 KB) Immunoglobulin G (IgG ; Serum) " Description of IgG (as part of Antibody Tests) (99 KB) " Serum C8 By lmmuno Ig obulin_G__(Seru m) Levefs In Particjpants >=1 And (23 KB) <Age " Serum C8 By Immunoglobulin G (Serum) Levels In Participants >-4 And <' Age (23 KB) " ASgereu(m23CK8BB)y immunoqtobulin G (Serum) Levels In Participants >-7 And -< " Serum C8 By Immunogfobulin G (Serum) Levels In Participants >-'10 And Of Age (23 KB) " Serum C8 By Immunoglobutin G (Serum) Levels In Participants >- ~12 And Of Age (23 KB) " Serum C8 By Immunoqlobu[in G (Serum) Levels In Participants >-14 And ~ Of Act e (23 KB) " Serum C8 By Immunogtobulin G (Serum) Levels In Participants >-16 And OfAge (23 KB) " Serum C8 By fmmunoglobuiin G (Serum) Levels In Participants >-20 (23 K " Serum C8 By Immunoglobufin G (IgG) Levels In Females Stratified By Age KB) " Serum C8 ByImmunogtobulin G~.IgG ) Levets In Males_ Stratified By Age-G~ http ://www.hsc .wvu.edu/som/cmed/c8/results/otherLaboratoryValues/index.asp 1/8/2009 , WVU : : School ofMedicine :: Community Medicine : : C8 P~'ge ? of 12 KB) " C8 Population Deciles & Immunoctlobuiin G (36 KB) Immunoglobulin M (IgM ; Serum) " Description of IgM (as part of Antibody Tests~ (99 KB) + Serum C8 By Immunoglobutin M (Serum) Levels In Participants >==1 And < Age (23 KB) " Serum C8 By lmmu no globulin M (Serum) Levels In Participants >==4 And < Ace (23 KB) + Serum C8 By Immunoglobulin M (Serum) Levels In Participants >=7 And < Age (23 KB) + Serum C8 By Immunoglobulin M (Serum) Levels In Participa nts >==10 And , A Ofge (23 KB) + Serum C8 By lmmunoqlobulin M (Serum) Levels In Participants >=-12 And Of Age (23 KB) " Serum C8 By Immunogtobulin M (Serum) Levels in Participants >=14 And OAfpe (23 KB) + Serum C8 By Immunoqlobulin M (Serum) Levels In Participants >--16 And Of Aae (23 KB) " Serum C8 By fmmunogfobulin M (Serum) Leve(s In Participants >=20 (231( + Serum C8 By lmmunoglobuiin M (igM) Levels in Females Stratified By Ag_e KB) " Serum C8 Bv Immunoalobulin M (IgM) Levels In Mates Stratified By Am-0 KB) + C8 Population De ciles & (mmunoglobulin M (37 KB) Insulin " Description of Insulin (37 KB) " Serum C8 By Insulin Levels In Fasting (Self Reported) Non-Diabetic Partici Years Of Age (23 KB) + Serum C8 By Insuli n Levels In Fasting-(Self Repartedl Non-Diabetic_Partic_i Years OfAge (23 KB) " C8 Population Deciles & Insulin (38 KB) Insulin-Like Growth Factor 1 (IGF-1) " Description of IGF-1 (50 KB) + Serum C8 By Insulin-Like Growth Factor 1 (IGF-1) Levels In Participants >= Ye ars Of Age (23 KB) " Serum C8 By Insulin-Like Growth Factor 1 IGF-1) Levels In Participants >- Years Of Age (23 KB) " Serum C8 By Insulin-Like Growth Factor 1 (IGF-1) Levels In Partici;pants >= <16 Years Of Age (23 KB) " Serum C8 By Insulin-Like Growth Factor 1 (IGF-1) Levels In Participants >: <18 Years Of Age (23 KB) " Serum C8 Bv Insulin-Like Growth Factor..1 (IGF-1) Levels In Participants >: <25 Years Of Age (23 KB) " Serum C8 By Insulin-Like Growth Factor 1 I~GF-11 Levefs In Participants >_ <30 Years OfAae (23 KB) " Serum C8 By Insulin-Like Growth Factor 1 (IGF-1) Levels In Participants >= <35 Years Of Age (23 KB) " Serurn- C8 By Insulin-Like Growth Factor 1 fGF-1 Levels In Participants >_ <40Years Of Age (23 KB) " Serum C8 By Insulin-Like Growth Factor 1 (IGF-1) Levels In Participants >= <45 Years Of Age (23 KB) " Serum C8 By Insulin-Like Growth Factor 1 (IGF-~Leveis In Participants ?_ <50 Years Of Age (32 KB) " Serum C8 By Insulin-Like Growth Factor 1 (IGF-1) Levels In Participants >= <55 Years Of Age (23 KB) + Serum C8 By Insulin-Like Growth Factor 1 (1GF-1 )_Lev_els !n Participants >_ http://www.hse .wvu .edu/sorn/emed/c8/results/otherLaboratoryValues/index.asp 1/8/2009 VVVU : : School ofMedicine :: Community Medicine : : C8 Pyge 8 of 12 <60 YearsOf Age (23 KB) " Serum C8 By Insulin-Like Growth Factor 1 (IGF-1) Levels In Participants Years Of Age (23 KB) ><65 " Serum C8 By Insulin-Like Growth Factor 1 (IGF-1) Levels In Participants >= _<70 Ye ars Of Age (23 KB) " Serum C8 Bv Insulin-Like Growth Factor 1 (IGF-1) Levels In Participants >_ <75 Years Of Age (23 KB) " Serum C8 By Insulin-Like Growth Factor 1 (IGF-1) Levels In Participants >= Of Age_(23 KB) " Serum C8 By Insulin-Like Growth Factor 1 (IGF-1) Levels In Females Strat Age-Group (30 KB) " Serum C8 By Insulin-Like Growth Factor 1 (IGF-1) Levels In Males Stratifie Group (31 KB) " 08 Population Deciles & Insulin-Like Gr owth Factor 'f (36 KB) Iron (Serum) " Description of Serum Iron (37 KB) " Serum C8 By Iron (Serum) Levels In Participants <18 Years Of Age (55 KE " Serum C8 By Iron (Serum) Levels In Participants >=18 Years Of Age (55 K " C8 Population Deci(es & Iron (37 KB) Lactate Dehydrogenase (LDIi) a Description of LDH (33 KB) " Serum C8 By LDH Levels In Participants <18 Years Of Age (23 KB) Serum C8 By LDH Levels In Participants >=18 Years Of Age (23 KB) C8 Population Deciles & Lactate Dehydrogenase (35 KB) Low Density Lipoprotein (LDL) Cholesterol (Calculated Value) " Description of LDL (41 KB) " Serum C8 By Low Density Lipoprotein (LDL) Cholesterol Levels In Particip~ And <20 Years Of Age (23 KB) " Serum C8 By Low Density Lipoprotein (LDL) Cholesterol Levels In Particip; Years Of Age (24 KB) " C8 Population Decife s & Low Density Lipo rotein (LDL) Cho[esterof (37 KB Lymphocytes " Description of__L~rm hoc t~es...~as ~art of C.o_lete_Blo od Coun~ (58 KB) " Serum C8Bv Lvmt~hocyte Levels In Parficipanfs <18 Years Of Age (23 KB " Serum C8 By Lymphocyte Levels In Participants >=18 Years Of Age (23 KI " C8 Population Deciies & Lymp hoc es (36 KB) Lymphocytes (Absolute) " Description of ~mphocytes (Absolute) (as part of Complete Blood Count) ( " Serum C8 By Lymphocyte (Absolute) Levels In Participants >-18 Years Of KB) " G8 Population Decifes & Lymphocytes (37 KB) Magnesium (Serum) " Description of Magnesium (35 KB) " Serum C8__By_ Ma. nesium (Serum~Leyels (n Partici.panfs_<6_Years i ~f Ag_e " Serum C8 By Magnesium (Serum) Levels In Participants >-6 And <12 Yea (57 KB) " Serum C8 By Magnesium (Serum) Levels In Participants >-12 Years Of Ac " C8 POPutatio-nD eciles & Magnesium (37 KB) http ://www.hsc .wvu .edu/som/cmed/c8/results/otherLaboratoryValueslindex .asp I/8/2009 WVU :: School of Medicine : : Community Medicine : : C8 PTge 9 of 12 Mean Corpuscular Hemoglobin (MCH) " Description of MCH (as part of Complete Blood Count) (58 KB) " Serum C8 By Mean Corpuscular Hemo fobin (MCH) Levels In Participants <10 Years Of Age (23 KB) " Serum C8 By Mean Corpuscular Hemoglobin (MCH) Levels In Participants <18 Years Of Age (23 KB) " Serum C8 By Mean Corpuscular Hemoglobin (MCH) Levels In Participants Of Age (23 KB) " C8 Population Deciles & Mean Corpuscular Hemoglobin (36 KB) Mean Corpuscular Hemoglobin Concentration (MCHC) " Description of MCHC (as part of Complete Blood Count) (58 KB) " Serum C8 By Mean Corpuscular Hemoglobin Concentration (MChIC Level Participants <18 Years Of Age (23 KB) " Serum C8 By Mean Corpuscular Hemoglobin Concentrati on (MCH C Level Participants >=18 Years Of &qe (23 KB) " C8 Population Deciles & Mean Corpuscufar Hemoglobin Concentration (37 Mean Corpuscular Volume (MCV) " Description of MCV (as part of Complete Blood Count) (58 KB) " Serum C8 By Mean Corpuscular Volume (MCV) Levels [n Participants <18 Age (23 KB) " Serum C8 By Mean Corpuscular Volume (MCV) Levels in Participants >=1 Age (23 KB) " C8 Population Deciles & Mean Corpuscular Volume (36 KB) Monocytes " Description of Monocytes (as part of Blood Differential) (39 KB) " Se rum C8 By Monocyte Levels In Participants <18 Years Of Age (23 KB) " Serum C8 By Monocyte Levels In Participants >=18 Years Of Age (23 KB) " C8 Population Deciles & Monocytes (37 KB) Monocytes (Absolute) " Description of Absolute Monocytes (as part of Blood Differential) (39 KB) " Serum C8 By Monocyte (Absolute) Levels (n Participants <18 Years OAf oc " Serum C8 By Monocyte (Absolute) Levels En Participants >=18 Years Of AE " C8 Population Deciles & Monocytes (Absolute) (38 KB) Neutrophils " Description of Neutrophils (as part of Blood Differential) (39 KB) " Serum C8 By Neutrophil Levels In Participants <18 Years Of Aoe (23 KB) " Serum C8 B.y_ Neutrophil Leyels In Participants >=18 Years Of Age (23 KB) " C8 Popufation Deciles & Neutrophits (36 KB) Neutrophils (Absolute) " Description of Absolute Neutrophiis (as part of Blood Differential) (39 KB) " Serum C8 By Neutrophil (Absolute) Levels In Participants <18 Years Of Ag " Serum C8 By Neutrophil (Absolute) Levels !n Participants >=18 Years Of A " C8 Population Deciles_& Neutrophifs- LAb- sol(uL3 e 8 KB) Phosphorus (Serum) http ://www.hsc .wvu.edu/som/emed/c8/results/otherLaboratoryValues/index .asp 1/8/2009 " WVU :: School of Medicine : : Community Medicine :: C8 Paye I~ of 12 " Description of Phos phorus (36 KB) " Serum C8 By Phosphorus (Serum) Levels In Participants <20 Years Of Ag " Serum C8 By Phosphorus (Serum) Levels In Participants >=20 Years Of At " C8 Population Deciles & Phosphorus (35 KB) Platelets " Description of Platelets (35 KB) " Serum C8 By Platelet Levels In Particlp ants <18 Years Of Age (55 KB) " Serum C8 By Platelet Levels In Participants >=18Years (?fAge (55 KB) " C8 Population Deciles & Platelets (37 KB) Potassium (Serum) " Description of Potassium (40 KB) " Serum C8 By Potassium (Serum) Levels n Participants <18 Years Of Age " Serum C8 Bv Potassium Serum~}Le_ves n Partieipants >=18 Years Of Actc " C8 Population Deciles & Potassium (37 KB) Prolactin " Description of Prolactin (34 KB) " Serum C8 By Prolactin Levels n Participants >=1 And <4 Years Of Age (2: o Serum C8 By Prolactin Levels n Participants >=4 And <7 Years Of Age (2: " Serum C8 By Prolactin Levels n Participants >=7 And <10 Years Of Age (: " Serum C8 By Prolactin Levels n Participants >=10 And <13 Years Of Age " Serum C8 By Prolactin Levels n Participants >=13 And <16 Years Of Age " Serum C8 By Prolactin Levels n Participants >=16 Years Of Age (23 KB) " C8 Po.pulation Deciles & Prolactin (37 KB) Prostate-Specific Antigen (PSA; Serum) o Description of PSA (36 KB) " Serum C8 By Prostate-Specific Antigen (Serum) Levels n Males <18 Year. (21 KB) " Serum C8~Prostate-~ Specffre Antigen_~Seruml Levels n Males >=18 Yea (21 KB) " C8 Population Deciles & Prostate-Specific Antigen (32 KB) Total Protein (Serum) " Description of Total Protein (34 KB) " Serum C8 By Protein (Serum) Levels n Participants <18 Years Of Age (23 " Serum C8~_Proten Serum Levels n Participants >=18 Years Of Ag e (1 o C8 Population Deciles & Total Protein (37 KB) Red Celt Distribution Width (RDW) " Description of RDW (as part of Complete Blood Count) (59 KB) " Serum C8 By Red Cell Distribution Width (RDW) n Participants <18 Years KB) " Serum C8 By Red Cell Distribution Wi dth RDW ln Partcipants >=18 Year (23 KB) " C8 Population Deciles & Red Cell Distribution Width (36 KB) Red Blood Celt Count (RBC) " Description of RBC (as part of Complete Blood Count) (59 KB) " Serum C8 By Red Blood Cell (RBC) Count n Participants <18 Years Of Ac http://www.hsc .wvu.edu/som/cmed/c8/results/otherLaboratoryValues/index .asp 1/8/2009  WVU :: School ofMedicine :: Community Medicine : : C8 Page 11 of 12 " Serum C8 Bv Red Blood Cell (RBC} Count In Participants >=18 Years Of P " C8 Population Deciles & RedBlood Cell Count (37 KB) Sodium (Serum) " Description of Sodium (37 KB) " Serum C8 By Sodium (Serum) Levels In Participants <18 Years Of Age (2 : " Serum C8 By Sodium (Serum) Levels In Participants >=18 Years Of Age (2 " C8 PQgulation Deciles & Sadium (38 KB) T3 Uptake " Description of T3 (36 KB) " Serum C8 By T3 Uptake Levels In Participants >=1 And <4 Years Of Age ( " Serum C8 By T3 Ugtake Levels In Participants >=4 And <7 Years Of Age ( : " Serum C8 By T3 Uptake Levels In Participants >=7 And <13 Years Of Age " Serum C8 By T3 Uptake Levels In Part icipants >=13 And <16 Years Of Agt e Serum C8 By T3 Uptake Levels in Participants >=16 And <18 Years Of Ag~ " Serum C8 By T3 Uptake Levels fn Participants >=18 Years Of Age (23 KB) " C8 Population Deciles & T3 Uptake (36 KB) Testosterone (Serum) " Description of Testosterone (39 KB) " Serum C8 By Testosterone (Serum) Levels In Participants >=1 And <6 Yee (23 KB) " Serum C8 By Testosterone (Serum) Levels In Participants >=6 And <8 YeE (23 KB) " Serum C8 By Testosterone ESerum) Levels In Participants >=8 And <_ 11 YE (23 KB) o Serum C8 Bv Testosterone (Serum) Levels In Participants >=11 And <13'Y Age (23 KB) " Serum C8 By Testosterone (Serum ) Levels In Participants >=13 And <16 'I Ace (23 KB) " Serum C8 By Testosterone (Serum) Levels In Participants >=16 Years Of i " C8 Population Deciles & Testosterone (35 KB) Thyroxine (T4) " Description of T4 (37 KB) " Serum C8 By Thyroxine T4) Levels In Participants <1 8 Years Of Age (56 F " Serum C8By Thyroxine (T4) Levels In Participants <18 Years Of Age (55 F " C8 Population Deciles & Thyroxine (T4) (37 KB) Triglycerides " Description of Triglycerides (41 KB) " Serum C8By_Trigbceride LeveCs In Fasting__.eff-_Re~ortedj Pa rticipants <1 Ag_e (23KB} " Serum C8 By Tricrlyceride Levels In Fasting (Self-Reported) Participants >= Of Age (23 KB) " C8 Popu(ation Deciles & Trigfycerides (37 KB) Thyroid Stimulating Hormone (TSH) " Description of TSH (36 KB) " Serum C8 By Thyroid Stimulating Hormone (TSH) Levels In Participants >= Years Of Age (23 KB) " Serum C8 By Thyroid Stimulating Hormone (TSH) Levels In Participants >= Years OfAge (23 KB) 12- http://www .hsc.wvu.edu/som/cmed/c8/results/otherLaboratoryValues/index .asp 1/8/2009 WVU :: School ofMedicine : : Community Medicine :: C8 .., Page 13 of 12 " Serum C8 By ThyroidStimutatFn~~[ormone TSH~ev efs In PartiGi pants >_ Of Aae (23KB) " C8 Population Deciles & Thyroid Stimulating Hormone (TSH) (36 KB) Uric Acid (Serum) " Description of Uric Acid (33 KB) " Serum C8 By Uric Acid (Serum) Levels In Participants >=1 And <4~ Years C KB) " Serum C8 By Uric Acid (Serum) Levels In Participants >=4 And <7 Years C KB) " Serum C8 By Uric Acid (Serum) Levels In Participants >=7 And <10 Years KB) " Serum C8 By Uric Acid (Serum) Levels In Participants >=10 And <13 Year: KB) " Serum C8 By Uric Acid (Serum) Levels In Participants >=13 And <16 Year; KB) " Serum C8 By Uric Acid (Serum) Levels In Participants >=16 And <18 Year : KB) " Serum C8 By Uric Acid (Serum) Levels In Participants >=18 And <60 Year; KB) " Serum C8 By Uric Acid (Serum) Levels !n Participants >=60 And <90 Year; KB) " Serum C8 By Uric Acid (Serum) Levels In Participants >=90 Years Of Age " C8 Population Deci(es & Uric Acid (36 KB) Vitamin B12 " Descri ption of Vitamin B12 (25 KB) " Serum C8 By Vitamin B12 Levels in Participants <18 Years Of Ae (23 KB " Serum C8 By Vitamin B12 Levels )n Participants >=18 Years Of Age (23 KI C8 Population Deciles & Vitamin B12 (37 KB) Very Low Density Lipoprotein (VLDL) Cholesterol (Calculated Value) Description of VLDL (24 KB) " Serum C8 By Very Low Density Lipoprotein VLDLI Cholesterot Levels In F <18 Years Of Age (23 KB) " Serum C8 By Very Low Density Lipoprotein VLDL Cholesterol Levels In F >=18 Years Of Acie (23 KB) " C8 Population Deci(es & Very Low ~Jensi~ LipoP-rotein VLDL) Cholestero ! White Blood Cell Count (VIIBC) " Description of WBC (37 KB) " Serum C8 By White Blood Celt (WBC) Count In Participants >=2 And <10 ` Age (47 KB) " Serum C8 By White Blood Cell WBC) Count In Participants >=10 And <18 _Age (55 KB) " Serum C8 By White Blood Cell (WBC) Count In Participants >=18 Years Or KB) " C8 Population Deciles & White Blood Cell Count (39 KB) WSechbomoalsotfeMred(iSciitneeDe( sRiogbenrbtyCV.tBVyUrdWeHebal. StehrSvciiceensces Center I P.O . Box 9100 1 Morgantown, UUV 265fl6-91(39 Last Modified : ,. @ 2009 West Vir http://www.hsc .wvu .edu/som/cmed/c8/results/otherLaboratoryValues/index .asp 1/8/2009 p. 13 , Association Between C8 Deciles and AFP Tumor Marker, Serum (ng-mL) Stratified by Age & Gender NOTE : The graph below depicts the association between the blood concentration of a "standard" clinical laboratory test for the corresponding population serum PFOA (C8) deciie. The results are stratified by age and gender categories. The association, if any, is univariate and therefore unadjusted for potential confounding variables or other mediating factors . Associations require further complex, multivariate analysis in order to ascertain the statistical and clinical meaning, if any . 40.00 r ~ 3D .0 C z -~`s 20i .(7 I-De trri z C 1t7 .i1 3 f4I O 0~ iTF CL -1 0-00- Age-Gender Group I Girls (Female, +s1 SYO) 1 Boys (Male, <18YO) ~ Women (Female, >=I 8YO) I Men (Male, >='I $'r'4) - ; -- - , ' _ . .. 1 2 3 4 5 Fi 7 8 9 1 Ct "Population Vecile Group -- C8 (PFOA)" Analvtic Note: Deciles were established using the entire population, not for specific age and / or gender sub-strata . 2009 West Virginia University School of Medicine Association Between C8 Deciles and Albumin, Serum (g~-dL) Stratitied by Age & Gender NOTE : The graph below depicts the association between the blood concentration of a "standard" clinical laboratory test for the corresponding population serum PFOA (C8) decile . The results are stratified by age and gender categories. The association, if any, is univariate and therefore unadjusted for potential confounding variables or other mediating factors . Associations require further complex, multivariate analysis in order to ascertain the statistical and clinical meaning, if any . ~crrai R ir 4 .60-' C 3 fD ti rb CL 4 .4(3 ft3 r a 4.so- Age-Gender Group I Girls (Female, <18'l0) I Boys (Male, <1 8YO) "' Women (Female, >=I 8YO) i I Men (Male, >=I 8YO) 5 s r' 8 9 16 ulation Decile Group -- C8 (PFt?A)" Analytic Note.: Deciles were established using the entire population, not for specific age artd /or gender sub-strata. 2009 West Virginia University School of Medicine p. 15 Association Between C8 Deciles and Alkaline Phosphatase, Serum ( ICJ-L) Stratitied by Age & Gender NOTE: The graph below depicts the association between the blood concentration of a "standard" clinical laboratory test for the corresponding population serum PFOA (C8) decile . The results are stratified by age and gender categories . The association, if any, is univariate and therefore unadjusted for potential confounding variables or other mediating factors. Associations require further complex, multivariate analysis in order to ascertain the statistical and clinical meaning, if any. CR 300 .00- a`' ?.5Q0 3 Ci 3 2[0. Age-Gender Croup ~ Girls (Female, <18't'o) 1 Bays (Male, <1 BYO) . ~ Women (Female, >=18Yf}) I Men (Mate, >=1 Br'1:3) fd~} -~s 1SQ .o C .... 3 1 00 .00- 0 ' Ci . 'L Z _Ou 50 .0 i ~ _- 1 v 3 +i 5 6 r 8 9 10 "Population aecile Group -- C8 (PFOA)" r Analvtic Note .. Deciles were established using the entire population, not for specific age and / or gender sub-strata. OO 2009 West Virginia University School of Medicine p. 16 -- Association Between C8 Deciles and ALT (SGPT) ( IU-L) Stratified by Age & Gender NOTE: The graph below depicts the association between the blood concentration of a "standard" clinical laboratory test for the corresponding population serum PFOA (C8) decile. The results are stratified by age and gender categories . The association, if any, is univariate and therefore unadjusted for potential confounding variables or other mediating factors. Associations require further complex, multivariate analysis in order to ascertain the statistical and clinical meaning, if any. 3s.o0Age-Gender Group I Girls (Female, <18Y3) ; I Boy- (Male, <18YO) V'iomen (Female, >=1 BYC)) ( ~ 1 Men (Male, >=18Y0) 30 . 00- C4 4) .,-.-.i. I ' ' .,- . 3t_o 25.0t3 IcDy 0 -- 2U-00~ f . i + ~' t t L 1- ~ f ,}q~,7 r r~ 15 .0011 - 1 2 3 4 5 S 7 8 9 10 "Population Decile Group -- C8 (RFf"A)" Ana/vtic Note Deciles were established using the entire population, not for specific age and/ or gender sub-strata. O 2009 West Virginia University School of Medicine p. 17 Association Between C8 Deciles and Antinuclear Antibodies _ Direct ( U-mL) Stratified by Age & Gender NOTE: The graph below depicts the association between the blood concentration of a "standard" clinical laboratory test for the corresponding population serum PFOA (C8) decile. The results are stratified by age and gender categories. The association, if any, is univariate and therefore unadjusted for potential confounding variables or other mediating factors . Associations require further complex, multivariate analysis in order to ascertain the statistical and clinical meaning, if any . 60.otr- r- e i7 rr 3 So .OCt- w 3 rr SL 4fi .l3illw [7 rr '_rt 3 3Q .1]D'" A O 'Lt. 20 .0f7" Age-Gender Group I Girls (Female, <18`v'4) I Boys (Male, <1$ YO) Women (Female, >=I 8YO) I Men (Male, >=18YO) 10 "Population Decile Group -- C8 (PFOA)"` Rnalvtic Note : Deciles were established using the entire population, not for specific age and/or gender sub-strata . 2009 West Virginia University School of Medicine p. 18 . Association Between C8 Deciles and AST (SGOT) ( IU-L) Stratified by Age & Gender NOTE: The graph below depicts the association between the blood concentration of a "standard" clinical laboratory test for the corresponding population serum PFOA (C8) decile. The results are stratified by age and gender categories . The association, if any, is univariate and therefore unadjusted for potential confounding variables or other mediating factors . Associations require further complex, multivariate analysis in order to ascertain the statistical and clinical meaning, if any . 30.00 " x 28 .i1o .0.0 . , 0 .~/ , f 1 ~. f : ,}, Age-Gender Group I Girls (Female, <9 8',It3) I I Boys (Male, <1 _xi`p) Women (Female, >=18i'O) I Men (Male, >=1BYf}) . ( ` 24 .0l;l .+~ c7 O CL 22 .00~ CL 20 .4Q, r ~ s.t~c~ 1 I , . . 2 3 4 5 6 P 8 9 10 "Population Decile Group -- C$ (PFOA)-" ` Analvtlc Notw peciles were established using the entire population, not for specific age and / or gender sub-strata. w .2009 West Virginia University School of Medicine p. 19 Association Between C8 Deciles and Baso (Absolute) ( x10e3-uL) Stratified by Age & Gender NOTE : The graph below depicts the association between the blood concentration of a "standard" clinical laboratory test for the corresponding population serum PFOA (C8) decile . The results are stratified by age and gender categories. The association, if any, is univariate and therefore unadjusted for potential confounding variables or other mediating factors . Associations require further complex, multivariate analysis in order to ascertain the statistical and clinical meaning, if any . : . .. - o.4 Cf CA Ct .435 Age-Gender Group I Girls (Female, <18YC9) I Boys Qtlale, <18Yf3) e= Women (Female, >=1 BYO} I Men ~t~ate, s=4 $iTo) a,. 0 0 .03- yi.+". .. . y . ' 0.025- 0 .0 Li .o1S 3{ ..3y P '3 '' , .. i ~:',. , . ~- . . .. . . . # .~ 3 . . . _ , . . . . . . . . . .. _ . _ ' , . . . . . .. . r ~.~~ . . . . .. , . . "l 2 3 $ 5 S 'f $ 9 1O "Population Decile Group -- CS (PFOA}" Anatvdc Note- Deciles were established using the entire population, not for specific age and / or gender sub-stra,t. a - O 2009 West Virginia University School of Medicine Association Between C8 Deciles and Basos ( %) Stratified by Age & Gender NOTE: The graph below depicts the association between the blood concentration of a "standard" clinical laboratory test for the corresponding population serum PFOA (C8) decite. The results are stratified by age and gender categories. The association, if any, is univariate and therefore unadjusted for potential confounding variables or other mediating factors . Associations require further complex, multivariate analysis in order to ascertain the statistical and clinical meaning, if any. Age-Gender Group T Girls (Female, <18YO) I Boys (P,Aale, <181fO) Women (Female, >=I 8YO) i Men (Male, >=1 8YO) 0 0 4~t 'A_r 0 L7t f_51 "Population Decile Group -- C8 (PFOA) Anatvtic Atotp: Deciles were established using the entire population, not for specific age and/or gender sub-strata. 2009 West Virginia University School of Medicine p. 21 Association Between C8 Deciles and Bilirubin, Direct ( mg-dL) Stratified by Age & Gender NOTE : The graph below depicts the association between the blood concentration of a "standard" clinical laboratory test for the corresponding population serum PFOA (C8) decite. The results are stratified by age and gender categories. The association, if any, is univariate and therefore unadjusted for potential confounding variables or other mediating factors . Associations require further complex, multivariate analysis in order to ascertain the statistical and clinical meaning, if any . Q.15Age-Gender Group ` 0 .14 - R =s. T i . , Girls (Female, 8~ S7) I Boys ~0~e <1 l ~ Men (Male , > =I 8YO) Cr 3 q D .13 - + i ! ts* _ 0 .12- ts C~L 0 .11 t1_14 r 0 .09 :; a f ` .. . .. ~ .. ~ r . . . - 1 = 3 4 5 6 7 g g 10 "Population Decile Group -- C8 (PFOA)" Ana/vtic- IVot~- Decifes were established using the entire population, not for specific age and/or gender sub-strata. 2U09 West Virginia University School of Medicine p. 22 Association Between C8 Deciles and Bilirubin, Total ( mg-dL) Stratified by Age & Gender NOTE: The graph below depicts the association between the blood concentration of a "standard" clinical laboratory test for the corresponding population serum PFOA (C8) decile. The results are stratified by age and gender categories. The association, if any, is univariate and therefore unadjusted for potential confounding variables or other mediating factors . Associations require further complex, multivariate analysis in order to ascertain the statistical and clinical meaning, if any . W 0 .55 z [A = Q .SQ C 3 ' 0 .45 3 f_t DAG ~ .. }. - . . . ... i . 1 Age-Gender Group I Girls (Female, s18'r'o) I Boys (Male, <18ir') Women (Female, >=98YO) I Men (tviate, -9 8'v`~) , ~ .. . ' ' a t . t y: 11 ~. .. . ~ .. , . . r . . i .7 . . . .. . . . . - . . . .~t ;, " . . - .~~~ . - .' . . ' . , . -, . . . .. . . . . . . . . .. . . . , , . . I i . .. . { . J' .. . . 't 2 J' 4 ~'J ~`7 ? $ 9 10 "Population Ctecile Group -- C8 (PFOA)" Anal ic Nole: eciles were established using the entire population, not for specific age and/or gender sub-strata. O2009 West Virginia University School of Medicine p. 23 Association Between C8 Deciles and BUN (mg-dL) Stratified by Age & Gender NOTE : The graph below depicts the association between the blood concentration of a "standard" clinical laboratory test for the corresponding population serum PFOA (C8) decile . The results are stratified by age and gender categories . The association, if any, is univariate and therefore unadjusted for potential confounding variables or other mediating factors . Associations require further complex, multivariate analysis in order to ascertain the statistical and clinical meaning, if any. 17 .1-D0Age-GenderGroup I Girls (Female, e1BYt)) ~ Boys (Male, <1$To) +~ Women (Female, >=I 8YO) 16 .00 ` I Men (t41ale, ~'_1 Si'3~ 15 .t)0 . . 3 F . `. 3 +v 14 .00- 0 \D E 13.1 :l0 RP s,a, 12 .r1~3 ,r . ;1 , . 1 } '~' t , lIl 11 , 1 ( ~, , ; t4' j t' '{ ' llF~ I . .. ~ . .. ~., ~1 ~, 7 7 t - 11 .QiJ . 1 2 3 4 S S 3 3 9 10 "Population C?eciie Group -- C8 (PFOA)" Ana! Fc Naite: Deciles were established using the entire population, not for specific age andl or gender sub-strata. 2009 West Virginia University School of Medicine p. 24 . Association Between C8 Deciles and BUN-Creatinine Ratio Stratified by Age & Gender NOTE: The graph below depicts the association between the blood concentration of a "standard" clinical laboratory test for the corresponding population serum PFOA (C8) decite . The results are stratified by age and gender categories . The association, if any, is univariate and therefore unadjusted for potential confounding variables or other mediating factors. Associations require further complex, multivariate analysis in order to ascertain the"statistical and clinical meaning, if any. 24.00- CI 22-00-- ., 3 20 .OiT r# i Y . .. . . .. , . ' . , '~ 18 .013-. . " 3 , . . .. , , , . . . , Age-Gender Group I Girls (Female, e1 aYt3) I Boys (Mate, <18 rQ) Mmen (Female, >=18V`~'J) I Men (toele, >_1 i;YO) . - 16 .013'Lt . fj~ 14 .001 ' . . . . f 1 2 3 4 5 0 7 8 S 10 "Population aecile Group -- C8 (PFOA)" Anal ic IVat ~P.: Deciles were established using the entire population, not for specific age and/or gender sub-strata. O 2009 West Virginia University School of Medicine p. 25 Association Between C8 Decifes and Calcium, Serum ( mg-dL) Stratified by Age & Gender NOTE : The graph below depicts the association between the blood concentration of a "standard" clinical laboratory test for the corresponding population serum PFOA (C8) decile . The results are stratified by age and gender categories . The association, if any, is univariate and therefore unadjusted for potential confounding variables or other mediating factors. Associations require further complex, multivariate analysis in order to ascertain the statistical and clinical meaning, if any . 10.20 ~' 10.10s Age-Gender Group I Girls (Female, <18YO) I Boys (Male, <18'r(3) .. ` 4^iQmen (Female, >='t OYC3) -ij I Men (Male, >=1 Si'i3) 3 10.00- : n 3 X O 5 .9~ " . - [ `j ] 1 t . .. . . . . . . . - ~ . . .. ~2 L2. .r. 9.70 ttt 1 2 3 4 5 6 7 8 9 10 "Population Decile Group -- C8 (PFOA)u AnalvtFc Notg; ecites were established using the entire population, not for specific age and/or gender sub-strata. 0'2 # Of & 2009 West Virginia University School of Medicine p. 26 Association Between C8 Deciles and Cancer Antigen (CA-125) (UImL) Stratified by Age & Gender NOTE : The graph below depicts the association between the blood concentration of a "standard" clinical laboratory test for the corresponding population serum PFOA (C8) decile. The results are stratified by age and gender categories . The association, if any, is univariate and therefore unadjusted for potential confounding variables or other mediating factors. Associations require further complex, multivariate analysis in order to ascertain the statistical and clinical meaning, if any. 5D .00- Age-Gender Group T Girls (Female, <18Y0) I Boys (Male, <1 BYO) Women (Female, -1 8YO) I Men (f0ale, >=18vO) 3 40 .00- , 3 0 30 .00- ' i 3 20 .0 0- t3'. ID 9 CID)CL +ty C 1p 0.0 1 "-? 3 4 5 6 7 3 9 10 "Population Ctecile Group -- C8 (PFOA)" A_Anal ic Alof -.: Deciles were established using the entire population, not for specific age and/or gender sub-strata. 2009 West Virginia University School of Medicine p. 27 Association Between C8 Deciles and CEA ( ng-mL) Stratified by Age & Gender NOTE : The graph below depicts the association between the blood concentration of a "standard" clinical laboratory test for the corresponding population serum PFOA (C8) decile . The results are stratified by age and gender categories . The association, if any, is univariate and therefore unadjusted for potential confounding variables or other mediating factors. Associations require further complex, multivariate analysis in order to ascertain the statistical and clinical meaning, if any. 6.00- 5 .00 :k rn >-n a.oo s.0o ' , Age-Gender Group T Girls (Female, <18Yt3) I BaYs 'Male, . < Women (Female, >=1 BYO) ~ Men (Mafe, a="18ifo) <' "YO, s~ z.~~~ . ~ .Q~a , tiT_ _ . .. . -' , , . y '. . . . 4 2 3 4 5 S 7 8 9 itl 'Population Decile Group -- C8 (PFOA)" Anaf ic Notw Deciles were established using the entire population, not for specific age and/or gender sub-strata. 2009 West Virginia University School of Medicine p. 28 . Association Between C8 Decites and Chloride, Serum ( mmol-L) Stratified by Age & Gender NOTE : The graph below depicts the association between the blood concentration of a "standard" clinical laboratory test for the corresponding population serum PFOA (C8) decile. The results are stratified by age and gender categories . The association, if any, is univariate and therefore unadjusted for potential confounding variables or other mediating factors. Associations require further complex, multivariate analysis in order to ascertain the statistical and clinical meaning, if any. ~ 104.50 ~` t 3 3 0 104.CtCt m 'rt 103.50 , j ' ~ Age-Gender Group 1 Girls (Female, <1 8YO) I Boys (Male, <1 BYO) ~. Women (Female, >=1 BYO) 1 Men (Male, >=18Y0) i +~ 1 03 .00. 0 102-50 ~. I 1 . _- 1 2 3 4 5 b' T 8 9 10 "Population Decile Group -- C8 (PFOA)" Anahrtic Note_: Deciles were established using the entire population, not for specific age and /or gender sub-strata . 02009 West Virginia University School of Medicine p. 29 x Association Between C8 Deciles and Cholesterol, Total ( mg-dL) Stratified by Age & Gender NOTE : The graph below depicts the association between the blood concentration of a "standard" clinical laboratory test for the corresponding population serum PFOA (C8) decile . The results are stratified by age and gender categories. The association, if any, is univariate and therefore unadjusted for potential confounding variables or other mediating factors. Associations require further complex, multivariate analysis in order to ascertain the statistical and clinical meaning, if any. CA 22~ .00 : " _' Q tn rr 200 00 .= . rr 'r ~ }' _------ . . Age-Gender Group ~ Ws (Female, c98YO) I Boys (t9tafe, <18YC7) : Mmen (Female, >=18fO) i rslen (Male, >=I 8'10) ' }' z~ . T - 18tr .0a c 160J00 - .CrL r . - (, T ` , ` 3 a 5 s 7 s e 10 "Population aecile Group -- C8 (PFOA)" Anal ic Not~P.: Deciies were established using the entire population, not for specific age and/ or gender sub-strata. 2009 West Virginia University School of Medicine p. 30 Association Between C8 Deciles and Cortisol ( ug-dL) Stratified by Age & Gender , _ ---- NOTE : The graph below depicts the association between the blood concentration of a "standard" clinical laboratory test for the corresponding population serum PFOA (C8) decile . The results are stratified by age and gender categories . The association, if any, is univariate and therefore unadjusted for potential confounding variables or other mediating factors . Associations require further complex, multivariate analysis in order to ascertain the statistical and clinical meaning, if any. ~~s .4ra '~ 13 .00 t ' `, . Age-Gender Group I Girls (Female, <1 8YO) I Boys (Male, <18!O) Women (Female, >=18`-(O) T rAeri (mare, >=1 svo) ul 1z.oo - ;n~0 11 .00 .. 10 .o0 I i , j 9.00- Ls. r 8.001 ,. 7 2 3 4 S 6 7 3 9 "tQ "Population C?ecile Group -- C8 (PF0A)u Anatvtic Not~P;_ Deciies were established using the entire population, not for specific age and/or gender sub-strata. 2009 West Virginia University School of Medicine p. 31 Association Between C8 Decifes and C-Reactive Protein, Quant (mg-L) Stratified by Age & Gender NOTE: The graph below depicts the association between the blood concentration of a "standard" clinical laboratory test for the corresponding population serum PFOA (C8) decile. The results are stratified by age and gender categories . The association, if any, is univariate and therefore unadjusted for potential confounding variables or other mediating factors. Associations require further complex, multivariate analysis in order to ascertain the statistical and clinical meaning, if any. to CA 6.0 t= ;3 .d . aLI _ 2_ sX 1 . . r. o. rJ .o . , . . . . ' . , . . .. .. . . , , -- ' ' , - . ,, Age-Gender Group ~ Girls (Female, e18'tt3) I Boys (Male, e18yo) Women (Female, >=1 BYO) I Men (Intale, >=18`v't}) .. . . . , , . - . ~. . . .y , .. . . . . ' . " . . , i . . R t .,; . , .- . .. . -- <. ' ,. "t ? S 4 5 S 7 8 9 10 "Population Clectle Group -- C8 (PFOA)" ~ Analytic Note : Deciles were established using the entire population, not for specific age andlor gender sub-strata . O 2009 West Virginia University School of Medicine p. 32 Association Between C8 Deciles and Creatinine, Serum ( mg-dL) Stratified by Age & Gender NOTE: The graph below depicts the association between the blood concentration of a "standard" clinical laboratory test for the corresponding population serum PFOA (C8) decile . The results are stratified by age and gender categories. The association, if any, is univariate and therefore unadjusted for potential confounding variables or other mediating factors. Associations require further complex, multivariate analysis in order to ascertain the statistical and clinical meaning, if any. rsr~ ~ _0 ' ..: 1 .1 ili . . Age-Gender Group I Girls (Female, e18Yo) Z Boys (Male, <1 8yo) Women (Female, >=1 OifC?) ` I Men (Male, >='t BYO) 3 k 1B " 1 .oC1 iJl Z z, - C r-, 0.9 3 cY 0 .8Q C O.7o ff'~3 r 0 .60, P ;- l ~ f ,; , ! T, I 1 2 3 4 5 6 7 8 9 10 "Population Decile Group -- CS (PFOA)" Analytic Notte- Deciles were established using the entire population, not far specific age and / or gender sub-strata. 2009 west Virginia University School of Medicine p. 33 Association Between C8 Decites and EOS ( %) Stratibed by Age & Gender NOTE : The graph below depicts the association between the blood concentration of a "standard" clinical laboratory test for the corresponding population serum PFOA (C8) decile. The results are stratified by age and gender categories . The association, if any, is univariate and therefore unadjusted for potential confounding variables or other mediating factors. Associations require further complex, multivariate analysis in order to ascertain the statistical and clinical meaning, if any. ~.2c- 3 .00 - R 2. $4 ; ' . 0 i AI 2 .60 ~` 1 . . ~, ~ ~ } j rp 2 .4t1 N ' ~ I - ^ 2.20 . L ~ . 'V . .. - .. . . . ' . I '' . - 100 . . . . , . . . ' r . . Age-Gender Group Girls (Female, e13YO) I Boys (Mate, <'tSyo) Women (Female, >=98YO) I Men (Male, >=1 Blro) I 1 .80 e 4 2 3 4 5 S i 8 9 44 "Population Decite Group -- C8 (PFOA) &4 Anal ic Not ~q: Deciles were established using the entire population, not for specific age and /or gender sub-strata. ---- O 2009 West Virginia University School of Medicine p. 34 Association Between C8 Decites and EOS (Absolute) ( x10e3-uL) Stratified by Age & Gender NOTE : The graph below depicts the association between the blood concentration of a "standard" clinical laboratory test for the corresponding population serum PFOA (C8) decile. The results are stratified by age and gender categories. The association, if any, is univariate and therefore unadjusted for potential confounding variables or other mediating factors. Associations require further complex, multivariate analysis in order to ascertain the statistical and clinical meaning, if any. ,~~ a ,~4. ul 0 .22- Cr In r~3 .-~r . . . _ a .2l7~ + Age-Gender Group I Girrls (Female, <1 8Y{3) I Boys (Male, <fi8YO) `: Women (Female, >=1 8YO) I Men (Male, >='1B'to) T a J 41 f ' fG 0.'1$ >_~ A 0 .115 IR CA) C 17- .14 ,i ~ ; .. . . . . ,4y . .. . `{ . .1 . . ": . ~. .5 . z~ .~. a'- . . . . .- . . . .. . . . . .. . . . " . . . . .. . . , . . _ ".. . ~ , .. . 1 2 3 4 5 t* 7 8 9 10 "Population LJecile Group -- C8 (PFOA)" 4,.1++ .~'' Anatvtic No~te; eciles were established using the entire population, not for specific age and /or gender sub-strata . 2009 West Virginia University School of Medicine p. 35 Association Between C8 Deciles and Estradiol ( pg-mL) Stratified by Age & Gender NOTE: The graph below depicts the association between the blood concentration of a "standard" clinical laboratory test for the corresponding population serum PFOA (C8) decile. The results are stratified by age and gender categories. The association, if any, is univariate and therefore unadjusted for potential confounding variables or other mediating factors. Associations require further complex, multivariate analysis in order to ascertain the statistical and clinical meaning, if any. 600.00- CA ~` z 500 .00 - - M 4o0.ao : ~ s00.o0 m 0 rCvL 200.Q0 c m W. 1.0Q04 r I~ .Oo - t~ '~l .' . . ~f~t . ', r . ' ;~ ~ ~: ~ ~ F` ~0 ~g, ~` ~. 1 2 3 4 s s 7 s sI _1T0 "Population Decile Group -- CS (PFOA)" Age-Gender Group I Girls (Female, K98irt3) I Boys (Male, <'f O'YO) Women (Female, >=I WYO) I Men (Iftle, >=18iO) Analytic N; . ote Deciles were established using the entire population, not for specific age and/ or gender sub-strata. 2009 West Virginia University School of Medicine Association Between C8 Decites and Folates (Folic Acid), Serum (ng-mL) Stratified by Age & Gender NOTE : The graph below depicts the association between the blood concentration of a "standard" clinical laboratory test for the corresponding population serum PFOA (C8) decile . The results are stratified by age and gender categories . The association, if any, is univariate and therefore unadjusted for potential confounding variables or other mediating factors . Associations require further complex, multivariate analysis in order to ascertain the statistical and clinical meaning; if any. Age-Gender Group Girls (Female, <1 8i'O) Boys (Mate, c18YK3) women (Female, 5=78YO) Men (fvtafe, >=l8`r't3) ? 3 ---- d _~ 7 S 9 10 "Population Decile Group -- C8 (PFOA)" Analytic Note: Deciles were established using the entire population, not for specific age and /or gender sub-strata . 2009 west Virginia University School of Medicine p. 37 Association Between C8 Deciles and Free Testosterone, Direct (pg-mL) Stratified by Age & Gender NOTE: The graph below depicts the association between the blood concentration of a "standard" clinical laboratory test for the corresponding population serum PFOA (C8) decile. The results are stratified by age and gender categories . The association, if any, is univariate and therefore unadjusted for potential confounding variables or other mediating factors. Associations require further complex, multivariate analysis in order to ascertain the statistical and clinical meaning, if any. ~s ~s W Ch 12. ~r C_? -_ a 'rt 10 .~1 . rr 0 3 S .Q . ~. ~~ ~` Age-Gender Group ~ Girls (Female, <1 8YO) 1 Boys (Ifdaie, <18YO) a. Women (Female, >=1$Yt7) i Men (Male, >=9 8YO) .. . . . . . . , .. , . . _ - _ .. . . , . . . . ., , , . 3 4.0~. . . . ; . . 2 .o ii .. . - . .. . ' , , ~ . . .' _ _ : . . ' 1 .. . . . .. . . .. . . i . " i1 . ... . _ .: . . , . . _. . ,' . "Fw , w V.43 f~ . .1) .X, 7 2 3 4 5 S 7 S 9 10 'Population Det:il$ Group -- C8 (PFOA)" Anal i _ Not Deciles were established using the entire population, not for specific age and l or gender sub-strata . 0 2009 West Virginia University School of Medicine p. 38 Association Between C8 Deciles and Free Thyroxine Index Stratified by Age & Gender NOTE: The graph below depicts the association between the blood concentration of a "standard" clinical laboratory test for the corresponding population serum PFOA (C8) decile. The results are stratified by age and gender categories . The association, if any, is univariate and therefore unadjusted for potential confounding variables or other mediating factors . Associations require further complex, multivariate analysis in order to ascertain the statistical and clinical meaning, if any. ,~ 2.50I Age-Gender Group t~t ' I Girls (Female, <1 8YO) I Bays (Male., <1 SfC23 y Y'Jbmen (Female, >=1 8YO) C ~ Meen (Male, >=1$Vo) _ Z "" -.1 2.40, t S f, i 3 Ot 3 CL ?.30j b+C l f l 3 d 0 2,20- =- r~ . ri 2.10 ; i 1 2 3 4 S S 7 8 9 10 "Population Ctecile Group -- C8 (PFOA)m Analytic Note ~ Deciles were established using the entire population, not for specific age and/or gender sub-strata. 2009 West Virginia University School of Medicine p. 39 Association Between C8 Deciles and GGT ( tU-L) Stratified by Age & Gender NOTE: The graph below depicts the association between the blood concentration of a "standard" clinical laboratory test for the corresponding population serum PFOA (C8) decile. The results are stratified by age and gender categories . The association, if any, is univariate and therefore unadjusted for potential confounding variables or other mediating factors . Associations require further complex, multivariate analysis in order to ascertain the statistical and clinical meaning, if any . t < 4i3 .GCt Age-Gender Group I Girls (Female, <1 BYO) Z Boys (Male, <18Y'O) ' Women (Female, >=1 BYO) I Men (Male, >=9 8Yo) 1 3 30 .00 ts , i ` _ l ;; .. . .~ . G ID 20 .00- C ~. .~r =~ t ~ , - 10 .00 L I T .r_ 3' ~',- a, 1 _ ~. f r i 2 3 4 5 6 7 a 0 10 "Population Ctecile Group -- C8 (PFOA" Analvtic Not~P.: Deciles were established using the entire population, not forspecific age and/or gender sub-strata. 2009 West Virginia University School of Medicine Association Between CS Deciles and Globulin, Total (g-dL) Stratified by Age & Gender NOTE : The graph below depicts the association between the blood concentration of a "standard" clinical laboratory test for the corresponding population serum PFOA (C8) decile. The results are stratified by age and gender categories. The association, if any, is univariate and therefore unadjusted for potential confounding variables or other mediating factors . Associations require further complex, multivariate analysis in order to ascertain the statistical and clinical meaning, if any . Age-Gender Group tt? I Girts (Female, <48YO) a I, Boys (Male, <'i$'`f') ~ Women (Female, >=9 8'1O) a I Men (f4efe, >=181tO) s' G_ 0 sa n 0 s` .r.a 3 4 5 6 7 10 "Population Decile Group -- C L ~~e: Deciles were established using the entire population, not for specific age and/ or gender sub-strata. 2009 West Virginia University School of Medicine Association Between C8 Deciles and Glucose, Serum ( mg-dL) Stratified by Age & Gender NOTE: The graph below depicts the association between the blood concentration of a "standard" clinical laboratory test for the corresponding population serum PFOA (C8) decile. The results are stratified by age and gender categories. The association, if any, is univariate and therefore unadjusted for potential confounding variables or other mediating factors . Associations require further complex, multivariate analysis in order to ascertain the statistical and clinical meaning, if any. Age-Gender Group I Girls (Female, <18`v'C)) I Boys (6Aate, <18YO) a =~ Women (Female, >=1 BYO) (t9}ale, >=1 SYt7) ts 03 C 3 3 C? 0 C tS.t Et. r a "Population Decile Group -- C8 Ft3A)"' Analvtic Note: Deciies were established using the entire population, not forspecific age and/or gender sub-strata. 2009 West Virginia University School of Medicine p. 42 Association Between C8 Deciles and HDL Cholesterol ( mg-dL) Stratified by Age & Gender NOTE : The graph below depicts the association between the blood concentration of a "standard" clinical laboratory test for the corresponding population serum PFOA (C8) decile . The results are stratified by age and gender categories . The association, if any, is univariate and therefore unadjusted for potential confounding variables or other mediating factors. Associations require further complex, multivariate analysis in order to ascertain the statistical and clinical meaning, if any. cro sc.[~~ r~-3 3 SS .I:1tJ 0 w .-r IP 5~~3 50 .001 _ c~3 1D f]. < 45 .L)0 #s! ID tL2 r 40.00 . ; , Age-Gender Group I Girls (Female, <18YO) i Boys (Iulale,,0 8'f{)) Women (Female, >-18YO) I Men (Male, >=1 8YO) ~ ( . ~ 4 7 ~ 1 2 3 4 5 6 i S 9 10 "Population Decile Group -- CO (PFOA)'" Analvtic No~ Deciles were established using the entire population, not for specific age and / or gender sub-strata . 2009 West Virginia University School of Medicine p. 43 Association Between C8 Decites and Hematocrit ( %} Stratified by Age & Gender NOTE: The graph below depicts the association between the blood concentration of a "standard" clinical laboratory test for the corresponding population serum PFOA (C8) decite. The results are stratified by age and gender categories . The association, if any, is univariate and therefore unadjusted for potential confounding variables or other mediating factors. Associations require further complex, multivariate analysis in order to ascertain the statistical and clinical meaning, if any. 46 .00 3 + 0 2 '3~ 44 .C1ri:1 c3r -s . 3 Ss1 42 . 10 C . ~ . g~ .{, '+;4 C 4i3 .U0- , , Age-Gender Group ~ I Girls (Female, <1 BYO) I Boys ( tutale, <18Yp) Women (Female, >=1 8YO) I Men (Male, >=18Yc3) ` ~ J . ~ 3 ~ 1 '? 3 4 S 6 3 8 9 10 "P opulation VeciIe Group -- C8 F (P OA)" Analyfic Note_ Deciles were established using the entire population, not for specific age and lor gender sub-strata. 2009 west Virginia University School of Medicine p. 44 Association Between C8 Deciles and Hemoglobin (g-dL) Stratified by Age & Gender NOTE: The-graph below depicts the association between the blood concentration of a "standard" clinical laboratory test for the corresponding population serum PFOA (C8) decile. The results are stratified by age and gender categories. The association, if any, is univariate and therefore unadjusted for potential confounding variables or other mediating factors . Associations require further complex, multivariate analysis in order to ascertain the statistical and clinical meaning, if any . 16.00- CA 0 15b0 , Age-Gender Group I Girls (Female, <1 8YO) I Boys (Male, <18Y(7) ' a V`,t6men (Female, >=1$Yt3) 1 Men (r4taie, >=Is;ro) F)7 15S-.0C00- 3 y 1 4 ..55103~X Q ,~ 1~# .C~ft C 1Ff 155 r r 13 .001 ` {~ ` ~ . '"+ .. , i " . . . - .,, - .. 1 '? 3 4 5 6 7 8 9 1i7 "Population Decile Group -- C8 (PFOA)" L/S Analytic Note : Deciles were established using the entire population, not for specific age and / or gender sub-strata. 2009 West Virginia University School of Medicine p. 45 Association Between C8 Decites and fmmunoglobulin A, Qn, Serum ( mg-dL) Stratified by Age & Gender NOTE : The graph below depicts the association between the blood concentration of a "standard" clinical laboratory test for the corresponding population serum PFOA (C8) decile . The results are stratified by age and gender categories . The association, if any, is univariate and therefore unadjusted for potential confounding variables or other mediating factors. Associations require further complex, multivariate analysis in order to ascertain the statistical and clinical meaning, if any . 0 C71 25o .0 a 3 225 .0 . _ ~ f' . . . . . . . . h I [~~;~ (~~3 , . . . . Age-Gender Group I Girls (Female, <98`rO) ~ Boys (Male, e18Yf}) ~ Women (Female, -1 8YO) ~ yl ` I Men (kriale, >=I BYO) . . yy, toV .f.f . . 3~ F' ~" 1as.o - i 3 !d 1 50 .00- . ~ ,25D _. ~ fA i'} _ . . . . . .. . . ' . . . . - . . t - 4 5 6 7 8 s ID "Population aecile Group -- C8 (PFOA)" Analytic Note: Decifes were established using the entire population, not for specific age and/or gender sub-strata0 2009 West Virginia University School of Medicine p. 46 Association Between C8 Deciles and Immunoglobulin E, Total (IUImL) Stratified by Age & Gender NOTE: The graph below depicts the association between the blood concentration of a "standard" clinical laboratory test for the corresponding population serum PFOA (C8) decile . The results are stratified by age and gender categories . The association, if any, is univariate and therefore unadjusted for potential confounding variables or other mediating factors . Associations require further complex, multivariate analysis in order to ascertain the statistical and clinical meaning, if any. 0 200,00- C 0 0 150 .00- 1 M 0 100 .00ri A 0 < Age-Gender Group Girls (Female, <1 8YO) 1 Boys (Male, <1 8YO) Women (Female, >=I 8YO) I Men (Male, >=I 8YO) 1 2 3 4 5 6 t I 7 1 8 4 9 110 "Population Decile Group -- C8 (PFOA)" Analytic Note: Deciles were established using the entire population, not for specific age and / or gender sub-strata. 2009 West Virginia University School of Medicine p. 47 Association Between C8 Deciles and Immunoglobulin G, Qn, Serum (mg-dL) Stratified by Age & Gender NOTE : The graph below depicts the association between the blood concentration of a "standard" clinical laboratory test for the corresponding population serum PFOA (C8) decile . The results are stratified by age and gender categories. The association, if any, is univariate and therefore unadjusted for potential confounding variables or other mediating factors . Associations require further complex, multivariate analysis in order to ascertain the statistical and clinical meaning, if any. W a 1.1810 3 1[l50 .0 3 1 Ct2[1 .13 Age-Gender Group I -irls (Female, el WfO) I Bays (Male, <1$'fo) 1 Women (Female, >=18YO) i Men (fatale, >=1 BYO) _q911 .Q C ~ f a 960 .0 +r~, 1 2 S 4 S 6 7 8 9 10 "Population Deci9e Group -- Ct# (PFOA)" 46 Analytic Note: eciles were established using the entire population, not for specific age and l or gender sub-strata. 2009 West Virginia University School of Medicine p. 48 Association Between C8 Deciles and Immunoglobulin M, Qn, Serum (mg-dL) Stratified by Age & Gender NOTE : The graph below depicts the association between the blood concentration of a "standard" clinical laboratory test for the corresponding population serum PFOA (C8) decile . The results are stratified by age and gender categories . The association, if any, is univariate and therefore unadjusted for potential confounding variables or other mediating factors. Associations require further complex, multivariate analysis in order to ascertain the statistical and clinical meaning, if any. CL - '140 .D r ~ z ' E 0 Age-Gender Group I Girls (Female, <18YO) T Boys (Ntale, a18YO) < Women (Female, >=1 8YO) - - - I C+Aen male, >=18YCr3 12C1 .0 . .. . . . -" J : = ,- . . . .. . . - . .. . . , " . . . . - , - . ' . . ,- . , . '-r_`n 1 1)0 .o 3 f~1 ~ ~ 1" t ~ ., , s y ; : , `;- , <-7 ` , , I ~ t I a 0 CL $0 .0 1 2 3 4 5 6 7 0 9 10 "Population Vecile Group -- C8 (PFOA)" I Analytic Note= Deciles were established using the entire population, not for specific age and / or gender sub-strata. 2009 West Virginia University School of Medicine p. 49 . Association Between C8 Deciles and Insulin, Fasting ( ulU-mL) Stratirted by Age & Gender NOTE: The graph below depicts the association between the blood concentration of a "standard" clinical laboratory test for the corresponding population serum PFOA (C8) decile . The results are stratified by age and gender categories. The association, if any, is univariate and therefore unadjusted for potential confounding variables or other mediating factors. Associations require further complex, multivariate analysis in order to I ascertain the statistical and clinical meaning, if any. CA 30.007: _ 28 .f7[1 3 id1 . .. 3 26 .00_n ttt W = 24 .00- - 22 .00- 0 1 20.00 < C 18.00- C 16_017 . v . . ~ ~ ~ . -, . . Age-Gender Croup z Girls (Female, <1 $Yo) 1 Boys (Male, <1 ayo) women (Female, >=18`(Cr) 1 Men (Male, s='1$YO) . - .. _ j I a ~ . p t r - 1 . - ,. . . 1 2 3 4 5 6 7 8 9 10 "Population Llecile Group -- sr+8 (rFsJil)u Analvtic No Deciles were established using the entire population, not for specific age and l or gender sub-strata. 2009 West Virginia University School of Medicine p. 50 Association Between C8 Deciles and Insulin-Like Growth Factor 1 (ng-mL) Stratified by Age & Gender NOTE : The graph below depicts the association between the blood concentration of a "standard" clinical laboratory test for the corresponding population serum PFOA (C8) decile . The results are stratified by age and gender categories. The association, if any, is univariate and therefore unadjusted for potential confounding variables or other mediating factors . Associations require further complex, multivariate analysis in order to ascertain the statistical and clinical meaning, if any. 3 'L" 4017 .7 . , 0 35lJ .QO = Age-Gender Group I Girls (Female, <11;YO) I Boys (Male, <1$YC?) : Women (Female, >=1 BYO) I Men (Male, >=18`v'O) 3ao. G) 0 ( -n 25Q .E1 ' L ~ ~I 1 , 200,00- 3 r't7 T 0~, CL . . . . . . = ~ . 100 .1~ S~I~/ . . . 1 2 3 4 5 6 7 8 9 10 '"Population Decile Group -- C8 (PFOA)' Anatvtic Note : Deciles were established using the entire population, not for specific age and / or gender sub-strata. O 2009 West Virginia University School of Medicine p. 51 Association Between C8 Deciles and Iron, Serum ( ug-dL) Stratified by Age & Gender NOTE : The graph below depicts the association between the blood concentration of a "standard" clinical laboratory test for the corresponding population serum PFOA (C8) decile. The results are stratified by age and gender categories . The association, if any, is univariate and therefore unadjusted for potential confounding variables or other mediating factors. Associations require further complex, multivariate analysis in order to ascertain the statistical and clinical meaning, if any. I DODOW tA _ 95 .00- t~ 3 ~` c > ' 90 .00 - r ! r. ell- z ` ( 85 .00: ii !If $i1 .011 ~ ' 1_ # ' fy1 C . , I Ago-Gender Group I Girls (Female, {1Bi'O) I Boys (Male, 18Yt3) =' Women (Female, -18YO) i . . . Z Men (Male, >=18YO) 1 75 .0ik r t,7. . w..+ . t 70D O- . . - . . . . . . . ,. . . . . . . . .. . 1 2 3 4 5 S 7 8 9 10 'Population LJe~.`ile Group -- 6s(7 (r'`OA)" V Anatvtfc Nate: ()eciles were established using the entire population, not for specific age and/ or gender sub-strata. 2009 West Virginia University School of Medicine p. 52 , Association Between C8 Deciles and LDH ( [U-L) Stratified by Age & Gender NOTE : The graph below depicts the association between the blood concentration of a "standard" clinical laboratory test for the corresponding population serum PFOA (C8) decile. The results are stratified by age and gender categories . The association, if any, is univariate and therefore unadjusted for potential confounding variables or other mediating factors . Associations require further complex, multivariate analysis in order to ascertain the statistical and clinical meaning, if any. : 220 .00- Q rr 20t1 .t3a 1eD> S2. CL ssr 180 .00- dr C z 3 .f- . . J T~ - ~ . .. ` 160 .00 1 9 2 3 4 S 6 7 B 9 1C? "Population V'~~.`~'~ Group -- C8 F (P OA)" Age-Gender Group I Girls (Female, <1 8YO) I Boys (Male, <1 8YO) Women (Female, a=18YO) I Men (Male, >=1 $'c"O) 5o A_natvtic Note . eciles were established using the entire population, not for specific age and/or gender sub-strata. O 2009 West Virginia University School of Medicine p. 53 Association Between C8 Deciles and LDL Cholesterol (Calculated) Stratified by Age & Gender NOTE : The graph below depicts the association between the blood concentration of a "standard" clinical laboratory test for the corresponding population serum PFOA (C8) decile . The results are stratified by age and gender categories . The association, if any, is univariate and therefore unadjusted for potential confounding variables or other mediating factors. Associations require further complex, multivariate analysis in order to ascertain the statistical and clinical meaning, if any. 120 .000 0 -01 -100 .00- Ago-Gender Group Girls (Female, <1 8YO) 1 Boys (I-Aale, <1 8yo) Women (Female, >=I 8YO) Men (10ale, >=1 8YO) TI 0 90DO- 11 0 CL < :41. C 80 .00- 0 r+ 70 .00- 1 2 3 4 5 S 7 8 9 1Q "Population Decile Group -- C8 (RFOA)" Analytic Note : Deciles were established using the entire population, not for specific age and ! or gender sub-strata . ( 2009 West Virginia University School of Medicine p. 54 Association Between C8 Deciles and Lymphs ( %) Stratified by Age & Gender NOTE : The graph below depicts the association between the blood concentration of a "standard" clinical laboratory test for the corresponding population serum PFOA (C8) decile. The results are stratified by age and gender categories . The association, if any, is univariate and therefore unadjusted for potential confounding variables or other mediating factors. Associations require further complex, multivariate analysis in order to ascertain the statistical and clinical meaning, if any. 37 .54 01 :z 3S .t71J 3 ~. ,p 3 11! - 32JV , . .. . T [I ~E ~ ! ! . ." , s. , 1 i ,. Age-Gender Group 1T Girls (Female, <18Y~3) i~. Boys (Mate, {1 cJ TO) Women (Female, >='i BYO) I Men (Male, a=18YO) iT +~~~5~y slSD Stql , 7~ i. " , . , - . .. . .. . . . ~ . . . - .. ' . . . 1 ,~. 2 7.~ ~41 . `#' . . . . .. . ". ' t. ' . t~ . . . . . . . ~ . ' . .. 1 2 3 4 5 6 7 8 9 11) "Population Decile Group -- C8 (PFOA)" el5Z,_) Analytic Note: eciles were established using the entire population, not for specific age and /or gender sub-strata. 2009 West Virginia University School of Medicine p. 55 Association Between C8 Deciles and Lymphs (Absolute) (x'I Oe3luL) Stratified by Age & Gender NOTE: The graph below depicts the association between the blood concentration of a "standard" clinical laboratory test for the corresponding population serum PFOA (C8) decile. The results are stratified by age and gender categories . The association, if any, is univariate and therefore unadjusted for potential confounding variables or other mediating factors. Associations require further complex, multivariate analysis in order to ascertain the statistical and clinical meaning, if any. r +~ 2 .$ 0 z .6' t~! ' .~ = ,- _3 . ~ ~ ~ ~ ? !. ~ 1 ~ :f( Age-Gender Group ' 1 Girls (Female, e1$i'o) I Boys (Male, -,I BYO) Women (Female, y=7$YO) a I Men (Male, >='I $YO) ; .. .4,~ L ' .r1 3 , 2.26- 0 sf.L j +e~ f_sl 2.$ t= 3E rD! 1 .$ ~ F . 1 .~. 'I 2 3 4 5 6 7 8 9 't o "Population C#ecile Group -- C8 (PFOA)" Analvtic Note : Deciles were established using the entire population, not for specific age and / or gender sub-sfrata. ~ 2009 West Virginia University School of Medicine p. 56 Association Between C8 Deciles and Magnesium, Serum ( mg-dL) Stratified by Age & Gender NOTE: The graph below depicts the association between the blood concentration of a "standard" clinical laboratory test for the corresponding population serum PFOA (C8) decile . The results are stratified by age and gender categories. The association, if any, is univariate and therefore unadjusted for potential confounding variables or other mediating factors. Associations require further complex, multivariate analysis in oi-der to ascertain the statistical and clinical meaning, if any . '2 . 1 3 Ill 2117 4n - s s 2 .I74 3 i ; ~ ` J I , 41 Age-Gender Group I Girls (Female, <1 8YO) T Bays (Male, <18YO) V,iamen (Female, >=18YO) 1 Men (Male, >=18'rt.'3) i# 2 .iQ1 1o f~ . C 1 .J tCt !3. r - 1 2 3 4 5 6 7 8 9 1o "Population Decite Group -- C8 (PFOA)" ~W Analytic Note: Deciles were established using the entire population, not for specific age and / or gender sub-strata. 2009 West Virginia University School of Medicine p. 57 . Association Between C8 Deciles and MCH ( pg) Stratified by Age & Gender NOTE: The graph below depicts the association between the blood concentration of a "standard" clinical laboratory test for the corresponding population serum PFOA (C8) decile. The results are stratified by age and gender categories. The association, if any, is univariate and therefore unadjusted for potential confounding variables or other mediating factors . Associations require further complex, multivariate analysis in order to ascertain the statistical and clinical meaning, if any. ' .Io ' F ~r ~ ,f : . 7 I5 . . ~. .>P . .~ . ~ '. . . _0 4 r 30 .SO. , " ,- . - , , . . .. . . .. , . . .. . ., . . . .. !_51 30 .40 s} O C . 29 .50' C ;- - .Q0 9P . .. . , . - .. . . - . , x ,.. . . : . ~ . , , Age-Gender Group I Girls (Female, <1 8YO) T Boys (Male, <18yo) 1 Women (Female, >=1 8YO) I fsen wale, >=98YO) ~3" _ _ . . .. . . 28 .501 . . . , . '. . ,, 'I 2 3 4 5 6 T a 9 10 "Population IJeci'e Group -- C8 (PFOAr 2 Analvtic Note: Deciles were established using the entire population, not for specific age andlor gender sub-strata . 2009 West Virginia University School of Medicine p. 58 . Association Between C8 Decites and MCHC (g-dL) Stratified by Age & Gender NOTE: The graph below depicts the association between the blood concentration of a "standard" clinical laboratory test for the corresponding population serum PFOA (C8) decile. The results are stratified by age and gender categories . The association, if any, is univariate and therefore unadjusted for potential confounding variables or other mediating factors . Associations require further complex, multivariate analysis in order to ascertain the statistical and clinical meaning, if any. 34.20- tyft 34 .i10~' 2 ,. . m 33 .80- ICD L c ~a r 33 .6i] r Age-Gender Group T Girls (Fe-tale, {78i'O) ' 1 Boys (Male, <18YO) Women (Female, >=18r`f3) I Men (Male, >=98YO) } f 1 2 3 4 5 6 7 8 g 10 "Population Qecile Group -- C8 (PFOA)" Analytic Note : Deciles were established using the entire population, not for specific age and l or gender sub-strata. 2009 West Virginia University School of Medicine p. 59 r Association Between C8 Deciles and MCV (fL) Stratit:ed by Age & Gender NOTE: The graph below depicts the association between the blood concentration of a "standard" clinical laboratory test for the corresponding population serum PFOA (C8) decite. The results are stratified by age and gender categories . The association, if any, is univariate and therefore unadjusted for potential confounding variables or other mediating factors . Associations require further complex, multivariate analysis in order to ascertain the statistical and clinical meaning, if any. 92.00- 0 SCT.Q~ 3 88.Od ID t~t . m _ P t 86 .00 . s , Age-Gender Group I Girls (Female, <18YO) Z Boys (Male, e18'fQ ) Women (Female, >=1 8Yt?) I Men (Male, >=18YO) . . " A 1 3 ; 8 9 10 "Population C?ecile Group -- C8 (PFOA)" Analvtic Note : Deciles were established using the entire population, not forspecific age and l or gender sub-strata. O 2009 West Virginia University School of Medicine p. 60 Association Between C8 Deciles and Monocytes ( !o) Stratified by Age & Gender NOTE: The graph below depicts the association between the blood concentration of a "standard" clinical laboratory test for the corresponding population serum PFOA (C8) decile. The results are stratified by age and gender categories . The association, if any, is univariate and therefore unadjusted for potential confounding variables or other mediating factors. Associations require further complex, multivariate analysis in order to ascertain the statistical and clinical meaning, if any. 8.00- !') q 7 .Stl Ct 0 7 .00 - 4n . ~ 5 .50 C. OD CL sr ~ 6 .iJ0 ' - Age-Gender Group ; , I Girls (Female, <'1 BYO) I Bays (Male, <1 BYO) i` Women (Female, >=1 OYO) I Men (Male, >=1 S'v' O) I - n ~ . ~ r: ,~ . ~. . J{' , - ~rt , ~' '~- I t jI - - , .. , . . . 5 .50 " ' . .. .. . .y . - . ... . : . . :. 1 2 3 4 5 6 7 S 9 'Population Decile Group -- +C8 (PFOA)" .. . . . . . . .. 10 61 [ A_Qalvtic Note: Deciies were established using the entire population, not for specific age and/or gender sub-strata. 2009 West Virginia University School of Medicine p. 61 Association Between C8 Deciles and Monocytes(Absotute) (x10e3-uL) Stratified by Age & Gender NOTE : The graph below depicts the association between the blood concentration of a "standard" clinical laboratory test for the corresponding population serum PFOA (C$) decile. The results are stratified by age and gender categories . The association, if any, is univariate and therefore unadjusted for potential confounding variables or other mediating factors. Associations require further complex, multivariate analysis in order to ascertain the statistical and clinical meaning, if any. I'~' = i_t? 0 .525- ~ ~ } : ( Age-Gender Group I Girls (Female, <1BYC}) I Boys (tftle, e18'fO) Women (Female, >=18Yf3) I Men (f:1ale, >='18'YO) R S/ .st ( 0 4 .47 f_s~ (1_4~ IA lt3r f~. < o .425 - _ . ~ . . ' , . I I ' j{+ 7/[ ~ ~ xtj/ '` 1 j z~ t~'i ~ S. I 1 . . . -. . . . . . . . . . . . x 0.4 i ? 3 4 5 S 7 B 9 10 "Population decile Group -- C8 (PFOA)" Analvtlc Note : Deciles were established using the entire population, not for specific age and / or gender sub-strata . 2009 West Virginia University School of Medicine p. 62 Association Between C8 Deciles and Neutrophils ( %) Stratitied by Age & Gender NOTE : The graph below depicts the association between the blood concentration of a "standard" clinical laboratory test for the corresponding population serum PFOA (C8) decile . The results are stratified by age and gender categories. The association, if any, is univariate and therefore unadjusted for potential confounding variables or other mediating factors. Associations require further complex, multivariate analysis in order to ascertain the statistical and clinical meaning, if any. . 62 .54 0 z 10 60 .00- Age-Gender Group I Girls (Female, <18YO) S Boys (Mate, <18 YO} ~ , Women (Female, >=1rsilO) I Men (Male, >=I 8YO) C) 0 CL CL 52 .50~ 1 2 3 4 5 6 7 i3 9 10 "Population i.1'ecile Group -- Lr8 (fFOA)rs I Analvtic Note_ eciles were established using the entire population, not for specific age and/or gender sub-strata. O 2009 West Virginia University School of Medicine p. 63 Association Between C8 Deciles and Neutrophits (Absolute) (x't Oe3-u L) Stratified by Age & Gender NOTE : The graph below depicts the association between the blood concentration of a "standard" clinical laboratory test for the corresponding population serum PFOA (G8) decile. The results are stratified by age and gender categories . The association, if any, is univariate and therefore unadjusted for potential confounding variables or other mediating factors. Associations require further complex, multivariate analysis in order to ascertain the statistical and clinical meaning, if any. r.a CA 5 .ct ~ 0 4 .75- . 0 ( Age-Gender Group Girls (Female, el BYO) I Boys (Male, <1 OYO) i Women (Female, >=18YC7) I Men (Male, n=1$`r't7) ; IJ rs' :~ . 4 .25- , ' CL ID~ ~ iE'~ ` < .~~ -~. ., ~ !D y+f . , -, _ 4j,. . . ~( ~ ` ~ ! L Li . .. . .. . . . , .. . . . . . . . .t . . . ,. 4 5 6 7 8 9 10 "Population Decile Group - srS7 (r"FOiS)u ! Analvtic Note : Deciles were established using the entire population, not for specific age and / or gender sub-strata. 2009 West Virginia University School of Medicine p. 64 Association Between C8 Deciles and Phosphorus, Serum ( mg-dL) Stratified by Age & Gender NOTE: The graph below depicts the association between the blood concentration of a "standard" clinical laboratory test for the corresponding population serum PFOA (C8) decile . The results are stratified by age and gender categories . The association, if any, is univariate and therefore unadjusted for potential confounding variables or other mediating factors . Associations require further complex, multivariate analysis in order to ascertain the statistical and clinical meaning, if any. . 3 ` ~,* =r 450- Age-Gender Group Z Girls (Female, e1 BYO) 1 Bays (Male, <10YO) r[ r Women (Female, >=1i3YO) I Men (Male, >=18Y3) 1 fJ'1 tzD ir 'T1 .+~ 0 3 .50- . ' l' s~+ ~y T 7Y ! +~ ry ~+ .L7 . . . ' . . - . , .. . _. . .. - . .. .. , , . . .. . . - . . . 1 i 3 4 5 6 i B 9 11! "Population Decile Group -- C8 (RFOA)" Analytic Note: Deciles were established using the entire population, not for specific age and /or gender sub-strata. 2009 West Virginia University School of Medicine p. 65 Association Between C8 Deciles and Platelets ( x10e3-uL) Stratified by Age & Gender NOTE: The graph below depicts the association between the blood concentration of a "standard" clinical laboratory test for the corresponding population serum PFOA (C8) decile. The results are stratified by age and gender categories . The association, if any, is univariate and therefore unadjusted for potential confounding variables or other mediating factors. Associations require further complex, multivariate analysis in order to ascertain the statistical and clinical meaning, if any. 340 .00 a -0 320 .00- ~ f ' Age-Gender Group I Girls (Female, e1 SYt3) I Boys (Male, <1 8YO) - Women (Female, >=18VO) ( , 1 Men (Male, >_1 8'r'O) , . ~_ 300 - .00 , . . S~ Y CL "P C ,,y~ L 280.00- ~ .IY ~ \Y 7PI_, 't,Y1i C r .00 240 .00 . , . , . . . . . , " . " , .. . . . . . . r . .. " . .. j"I . . . r (S "" . , . . tf , `1` ,T . . x . . . . . . . .. .. - 1 . . . . . . _ . . . . jj . +t ^ . . . . . nr ~'F . ' . . . .. . . . . .. 1 2 3 4 5 S 7 8 9 1Q "Population Deci1e Group -- Sr8 (PFOA)u AnalvtFc Note : Deciles were established using the entire population, not for specific age andlor gender sub-strata . O 2009 West Virginia University School o# Medicine p. 66 Association Between C8 Deciles and Potassium, Serum ( mmol-L) Stratified by Age & Gender NOTE The graph below depicts the association between the blood concentration of a "standard" clinical laboratory test for the corresponding population serum PFOA (C8) decile. The results are stratified by age and gender categories . The association, if any, is univariate and therefore unadjusted for potential confounding variables or other mediating factors. Associations require further complex, multivariate analysis in order to ascertain the statistical and clinical meaning, if any. Cy,l a.~ 4 .25 . f L. 'T .L Y _ ~ , _-- Age-Gender Group Girls (Female, <1 BYO) I Boys (Male, <1 8YO) _ Women (Female, >=1 BYO) T Men (Male, >=18r'o) L.yi, . . . . X t .1~ !D } O Yt _' " ^\i 4 .1 - , - . Y .J . ' . .++ j { 5 ' I 1 r , - . .. . F J 7 {{ . . { . _ ~ i . . . . , - - . . . . . - . - , 1 ? 3' 4 5 S 7 $ 9 10 "Population Decile Group -- C8 (RFOA)" ( Analytic Note- Deciles were established using the entire population, not for specific age and /or gender sub-strata. 2009 West Virginia University School of Medicine p. 67 Association Between C8 Deciles and Profactin ( ng-mL) Stratified by Age & Gender NOTE : The graph below depicts the association between the blood concentration of a "standard" clinical laboratory test for the corresponding population serum PFOA (C8) decile. The results are stratified by age and gender categories . The association, if any, is univariate and therefore unadjusted for potential confounding variables or other mediating factors. Associations require further complex, multivariate analysis in order to ascertain the statistical and clinical meaning, if any. 16.00 , ~; 14 .O0 c3 R+ri 0 j 12 .(lil t_v (D 0 10 .004, CL C :3 _r { ~ . ~ ~ ., ( I# t ' 4 - I ~1 ~ s 1 j ` 6.00 1 r 3 4' S 6 7 B 9 10 "Population Ctecile Group -- C8 (PFOA)" Age-Gender Group T Grls (Female, <1 Si'O) I Bays (Male, <18YiJ) -- Women (Female, >=1 BYO) I Men (ts1ale, >=1 BYO) 4e Analvtic Note~ Deciles were established using the entire population, not for specific age and /or gender sub-strata . 0 2009 West Virginia University School of Medicine p. 68 Association Between C8 Deciles and Prostate-Specific Antigen, Serum (ng-mL) Stratified by Age & Gender NOTE : The graph below depicts the association between the blood concentration of a "standard" clinical laboratory test for the corresponding population serum PFOA (C8) decile . The results are stratified by age and gender categories . The association, if any, is univariate and therefore unadjusted for potential confounding variables or other mediating factors. Associations require further complex, multivariate analysis in order to ascertain the statistical and clinical meaning, if any. W ~ 2. S ~"~'# 3 0 2.00rr ID Ip cx Age-Gender Group I ~~ i~le~ ~~fi8'x'O) - ' ' i T' - i- x ~ . ty!~I i ( . , - Y . ~ . . ;17)3 . , .. ' . , . . . . .. { . . SI .J o.o ~ JF ^,~ . "11~~ (D' --C~ .;- . .. , ., ' .. ' ..a a 'I ? 3 4 5 6 3 $ 9 90 "Population Veci'e Group -- C8 (PFOA)" Anatvtic Note: Decites were established using the entire population, not for specific age and/ or gender sub-strata. r 2009 West Virginia University School of Medicine p. 69 Association Between G8 Deciles and Protein, Total, Serum ( g-dL) Stratiffed by Age & Gender NOTE: The graph below depicts the association between the blood concentration of a "standard" clinical laboratory test for the corresponding population serum PFOA (C8) decile . The results are stratified by age and gender categories. The association, if any, is univariate and therefore unadjusted for potential confounding variables or other mediating factors . Associations require further complex, multivariate analysis in order to ascertain the statistical and clinical meaning, if any. 'rs ii'1 -s srs+ 7 .5 ..t . , ICL i` , 7 .2 . . , _ , . t , , .. 4 Age-Gender Group I Girts (Female, 0 BYO) i Boys (Male, <9 8't`C3) , Women (Female, >=1 BYO) I Men (Male, >=9 8Yt5) , , :- -- - 1 2 3 4 5 6 Z 8 9 70 "Population Clecile Group -- C## (PFOA)," Analvtfc Note: Deciles were established using the entire population, not for specific age and / or gender sub-strata. , Oc 2009 West Virginia University School of Medicine p. 70 Association Between C8 Deciles and RDW ( %) Stratified by Age & Gender NOTE: The graph below depicts the association between the blood concentration of a "standard" clinical laboratory test for the corresponding population serum PFOA (C8) decite . The results are stratified by age and gender categories. The association, if any, is univariate and therefore unadjusted for potential confounding variables or other mediating factors. Associations require further complex, multivariate analysis in order to ascertain the statistical and clinical meaning, if any. 14 .25. Age-Gender Group T Girls (Female, <1 aYt}) i Boys (Male, <18Y)) Women (Female, >=18"r`O) ' I Men (Male, >=1 8YO) 14 .00- , 'rt = 13 .75- ID , Lt 1 3 .~0' , . .. 13 .25a <' c, I . - 13 .001 1 2 3 4 5 6 7 8 9 10 "Population E3ecile Group -- t;8 (PFOA)" ( Analytic Note_ Deciles were established using the entire population, not for specific age and /or gender sub-strata . 2009 West Virginia University School of Medicine p. 71 Association Between C8 Deciles and Red Blood Cell Count (x10e6-uL) Stratified by Age & Gender NOTE: The graph below depicts the association between the blood concentration of a "standard" clinical laboratory test for the corresponding population serum PFOA (C8) decile. The results are stratified by age and gender categories . The association, if any, is univariate and therefore unadjusted for potential confounding variables or other mediating factors . Associations require further complex, multivariate analysis in order to ascertain the statistical and clinical meaning, if any . CD W r- '^ r '_t7 5 .00- cr CL 0 4 .8 o c r* 3 fY1 a 4.6 ~t - . . ~ ; C . .-.:., . . . A. . :. := - ._:.. ._ . _ . .. i . _ Age-Gender Group I Girls (Female, <181'O) 1 Boys (Male, <1 8'r`4) women (Female, >=18'YC1) I Men (I0ale, >=18YO) l X ~3 C~ 4 .4 ID . . . . ' 1 2 3 4 S 6 t $ 9 10 'Population Dectle Group -~ C8 (PFOA)" 6 Analytic Note: Deciles were established using the entire population, not for specific age and/or gender sub-strata . 2009 West Virginia University School of Medicine p. 72 Association Between C8 Deciles and Sodium, Serum ( mmot-L) Stratified by Age & Gender NOTE : The graph below depicts the association between the blood concentration of a "standard" clinical laboratory test for the corresponding population serum PFOA (C8) decife. The results are stratified by age and gender categories . The association, if any, is univariate and therefore unadjusted for potential confounding variables or other mediating factors . Associations require further complex, multivariate analysis in order to ascertain the statistical and clinical meaning, if any. r2s5, 141 .2t7 a 0 ~,. 1 #1 .[it} tt"! N 140.80- _ `~ `} _ ~ r Age-Gender Group I Girls (Female, <1 8YO) 1 Boys (Male, <18Yi:?) ' Women (Female, >=18ftJ) I Men (Male, >=18YO) 140.600 CL L sti 140 .40- 3 0 r e 140_2rJ ( F } 3 A-1 t : 1 2 3 4 S 6 i S 9 10 "Population Decile Group -- C8 (PFOA)" Analytic Note : Deciles were established using the entire population, not for specific age and l or gender sub-strata . 2009 West Virginia University School of Medicine p. 73 Association Between C8 Deciles and T3 Uptake ( %) Stratified by Age & Gender NOTE: The graph below depicts the association between the blood concentration of a "standard" clinical laboratory test for the corresponding population serum PFOA (C8) decite. The results are stratified by age and gender categories . The association, if any, is univariate and therefore unadjusted for potential confounding variables or other mediating factors . Associations require further complex, multivariate analysis in order to ascertain the statistical and clinical meaning, if any . . . .w;: .._ _, . . ....:,., . . . , ...: . _ .. . x: . 32 .44 +w , `r 31 .00- 3 C,p)' 30.4 C ~"+ 29 .AG1 Age-Gender Group I Girls (Female, <18YO) b Boys (tvtate, <18ifO) . = Women (Female, >=18''o ~ I Men (Mete, >=18i'O) 7 ` . 1 2 3 4 S & 7 'd 9 14 "Population Decile Group -- C8 (PFOA)" 114 nalvtFc Note : Decites were established using the entire population, not for specific age and / or gender sub-strata. 2009 West Virginia University School of Medicine p. 74 Association Between C8 Deciles and Testosterone, Serum (ng-dL) Stratified by Age & Gender NOTE: The graph below depicts the association between the blood concentration of a "standard" clinical laboratory test for the corresponding population serum PFOA (C8) deci[e. The results are stratified by age and gender categories . The association, if any, is univariate and therefore unadjusted for potential confounding variables or other mediating factors . Associations require further complex, multivariate analysis in order to ascertain the statistical and clinical meaning, if any. 400 .00- 4, 3oUJLt O 1d U) N-s 3 2o .d , i ~ `~ - ~[+ t3r 0 CL 100 .00-1-11 .1. 33. Age-Gender Group I Girls (Female, <1$YO) 7 - Z Boys (Male, <1$YO) g Women (Female, n=I8`r`O) I Men (Male, >=I 8YO) , ~ C. - _ C 3 t~t t) .o 1 2 3 4 5 6 7 8 9 10 "Population Decile Group -- C8 (PFOA)" I 1-~ AnaIvtFc Note : Deciles were established using the entire population, not for specific age and/or gender sub-strata. 2009 West Virginia University School of Medicine p. 75 Association Between C8 Decifes and Thyroxine (T4) ( ng-dL) Stratified by Age & Gender NOTE: The graph below depicts the association between the blood concentration of a "standard" clinical laboratory test for the corresponding population serum PFOA (C8) decile. The results are stratified by age and gender categories . The association, if any, is univariate and therefore unadjusted for potential confounding variables or other mediating factors. Associations require further complex, multivariate analysis in order to ascertain the statistical and clinical meaning, if any . . ~ `o ` Ci . - , Age-Gender Group -1 Girls (Female, <1 BYO) 1 Boys (Male, <1$YO) ~Nomen (Female, n=7 BYO) I Men (Male, >=18Yt7) I . . ` . . . . . ~{ 1 . . . IT .50 ii .00 3 r = s.~a , ~ ". ` . "_ . . " .' . . " _. m # ? , . .. . .. . . . ... b . - . . . ... . k . 1 2 3 4 5 6 7 8 9 10 "Population Qecile Group -- CO (PFOA)" 767 Analytic Note : Deciles were established using the entire population, not for specific age and /or gender sub-strata. 0 2009 West Virginia University School of Medicine p. 76 Association Between C8 Decites and Triglycerides ( mg-dL) Stratified by Age & Gender NOTE : The graph below depicts the association between the blood concentration of a "standard" clinical laboratory test for the corresponding population serum PFOA (C8) decile. The results are stratified by age and gender categories . The association, if any, is univariate and therefore unadjusted for potential confounding variables or other mediating factors . Associations require further complex, multivariate analysis in order to ascertain the statistical and clinical meaning, if any. ~. 225 .Q4 = 200.00~ _n 1fs.0o A 0 t3 15IU .t1~ ~, .1 Age-Gender Group I Girls (Female, c'i 8YO) r Boys (Male, .1 c ; . Women (Female, n='t 8YO) I Men (Male, >=7 BYO) "Yo) 1 . . : . . . . .. : . . 125 .t7o ? ~ . ti m 100.00 : . ' . .. 1 2 3 d 5 6 7 8 S 10 "Population decile Group -- C8 (PFOA)" Analvtfc Note: DeciFes were established using the entire population, not for specific age and/or gender sub-strata. 2009 West Virginia University School of Medicine p. 77 Association Between C8 Deciles and TSH ( ulU-mL) Stratified by Age & Gender NOTE : The graph below depicts the association between the blood concentration of a "standard" clinical laboratory test for the corresponding population serum PFOA (C8) decile. The results are stratified by age and gender categories . The association, if any, is univariate and therefore unadjusted for potential confounding variables or other mediating factors . Associations require further complex, multivariate analysis in order to ascertain the statistical and clinical meaning, if any. 3 .~(} 01 0 3 .[IQ Un 2 3 2 . t3.. 1tw ~ 2-OU r 1 .5t1 _ _. _. _ Age-GPnfer Group I Girls (Female, <4SYO) T Brays (Male, <78YO) Women (Female, >=I 8YO) Z Men (Male, >=9 3YO) ' t~ ~ r ~ '~ s - "I 2 3 tF S 6 7 B 9 1 0 "Population Decile Group -- C8 (PFOA)" Analvtic Note= f3eciles were established using the entire population, not for specific age and/or gender sub-strata . 2009 West Virginia University School of Medicine p. 78 Association Between C8 Deciles and Uric Acid, Serum ( mg-dL) Stratified by Age & Gender NOTE: The graph below depicts the association between the blood concentration of a "standard" clinical laboratory test for the corresponding population serum PFOA (C8) deciie . The results are stratified by age and gender categories . The association, if any, is univariate and therefore unadjusted for potential confounding variables or other mediating factors. Associations require further complex, multivariate analysis in order to ascertain the statistical and clinical meaning, if any . 6.50- y 7~ S.00 . ~ ~' . ; ., 4 ' . , Age,-Gender Group I Girls (Female, e1 8Y17) I Boys (Male , <18YO) ' Women (Female, >=18'Yl`i) I Men ( M ale, >= 18Y3 ) U! S .Sti ..., 'n S .UD cx yro EtF J0 , . " t~ ~;, . , , - - -. , " -. . .. , , - , ~~ . . j' . . . . .. . .. .i . . . . r e ~l .(1 ` 1 . ... . . . .. 2 3 4 5 6 7 8 9 10 "Population D!ecile Group -- C8 (PFOAr Anattdic Note : Deciles were established using the entire population, not for specific age and/or gender sub-strata. 2009 West Virginia University School of Medicine p. 79 Association Between C8 Deciles and Vitamin B12 ( pg-mL) Stratified by Age & Gender NOTE : The graph below depicts the association between the blood concentration of a "standard" clinical laboratory test for the corresponding population serum PFOA (C8) decile. The results are stratified by age and gender categories . The association, if any, is univariate and therefore unadjusted for potential confounding variables or other mediating factors . Associations require further complex, multivariate analysis in order to ascertain the statistical and clinical meaning, if any . 6 . .5 1i 0 4 c sar _ r TF , 3 s0o.04 F~ r+,. - -il 3 ~'! SS.Cl cf O CL C 5C10 .i3o . ~T 3 _{ . 11 . - - `. . . . . Age-Gender Group ~I Girls (Female, 518i'O) I Boys (Mate, e18's'O) 7 Women (Female, >=I8YO) I Men (Male, >=18"YC)} . . . . , ., r t 4550 .00 ., > ~ t '~ ~ 1 . . . . . .. . . . . s a s s 7 8 s 10 "Population Decile Group -- C8(PFOAr (50 ( Analvtic Note : Deciles were established using the entire population, not for specific age and/or gender sub-strata. 2009 West Virginia University School of Medicine p. 80 Association Between C8 Deciles and VLDL Cholesterol (Calculated) ( mg-dL) Stratified by Age & Gender NOTE : The graph below depicts the association between the blood concentration of a "standard" clinical laboratory test for the corresponding population serum PFOA (C8) decile . The results are stratified by age and gender categories . The association, if any, is univariate and therefore unadjusted for potential confounding variables or other mediating factors. Associations require further complex, multivariate analysis in order to ascertain the statistical and clinical meaning, if any . CA 40 .000 ~ r C Cr1 0 35 .00=r r* ., . . 3tJ .o s .* t~. 25 .11 ~i7 CL CL 2tl .o ; . Age-Gender Group I Girls (Female, <18Y0) < ~ Boys (Male, <9 8`l0) ." ` T: WMoenme(Mnal(eF,em>a=l1e8,Y>O=)9 8YC+) ~ ~ ;# 1 - ` i 2 3 4 5 e 7 a s 10 "Population Qecile Group -- CS (PFOA)" 491 Analvtic Note : Deciles were established using the entire population, not for specific age and /or gender sub-strata . 2009 West Virginia University School of Medicine p. 81 J Association Between C8 Deciles and White Blood Cell Count (x10e3-uL) Stratified by Age & Gender NOTE : The graph below depicts the association between the blood concentration of a "standard" clinical laboratory test for the corresponding population serum PFOA (C8) decile . The results are stratified by age and gender categories . The association, if any, is univariate and therefore unadjusted for potential confounding variables or other mediating factors. Associations require further complex, multivariate analysis in order to ascertain the statistical and clinical meaning, if any . r0a WCh s. ~ .~.. 0 a 3. 7.8 _~ Q 7.6 , Ot ;. . >: Age-Gender Group I Girls (Female, <18'r'o) I Boys (Male, c18'fo) Women (Female, }=1 BYO) I Men (tvlate, >=18i(o) ) ca . i r2~ . ~ }l 00- TOG- . ` .} ss . ~ - 1 L 3 4 S 6 7 S 9 1i} "Population Cte'cr1e Group -- C8 (PFOA)" z Analytic Note= Qeciles were established using the entire population, not for specific age and/ or gender sub-strata. 2009 West Virginia University School of Medicine