Document OznLdYRRXqEYp6oMBOYye48aK

wt. remain* nnclmigce, the new substance i* believed to be tlw (OHXPOili. After activation to Ca,Ni(PO), life of catlyd ci* isomer of I. A. Baidiits during described dehydrogenation procai b compared with Alkali metil .V. A'-dislkyldithioearbimite*. Stilt Akerstrom Ca^l'O.VCadOHXl'O.). (A/B) when this value b >2. buta and Anders llilin (Univ. L'|>l>suUi, Sivvtl.). Arki* Ktmi 24(34), diene pruduccd/kg. catalyst U >500. For example, the tabu 503-4(I9Wi)(Eng); cf. CA 01, 7tIJ4c. The folluwinc data are lated result! were obtained. The catalyat i* steamed to total reported (inital in RuiNCSjM, m.p., no. of associated molecules * in ClK-'li . iln., di-til. elnillioscupically): is. II: Hli, 148-50', 5; C*, lfiS-U*. 4. Tlw distribution cuelliciviit {/) of (lUljlt Cm ftBiilim otulybt Nl ro, CriOl C Afc A/B RiNCSjN'a (I) bclwriu CI1CI,II,0 is siniimari/ad as follow* (k in I, /): Mr, 0.9 X In lit, J8 x 10"*; I'r, 27u X I0"*; and Bu, 700 X 10". Harry I,. Vale _ Mamedov, M.: Vinilkhlorid (Vinyl Chloride). Baku: Azerb. t t z 30 24 ft.tr ftft 89 1.9ft S.ftV .M ft.14 M.tt 1.91 9 93 39.60 ft.97 ft6 ftft 1.7ft 9.31 w-- -- 9.16 2.19 1.37 ft4 $ 93A.94 IM.M ft4 30 U ft, 30 ftft 46 1 M 9.40 0.ft3 1.37 179 32 39 97 ft.VO ft.? ! 1.14 9 94 0.43 1 96 244 62 30 99 ft. ft 1.70 9.91 0.49 1.4ft 7m 09 Cus. ltd, IWr4.- 127 pp. Smith. Peter A. S.: The Organic Chemistry of Open-Chain activation in dosed reactors at 300-400*. After bomLog the lubricant with 0, and steaming to 565-580*, several route* are Nitrogen CtHtipounds. Vol, I. Xrw York: benjamin. 1005. described to bring the temp, to operating conditions. For ex 4i8 pp. ample, temp, was kept at 566* for 8 bis., increased by 2JS*/S hr*, to 593*, 2-8*/12 tin. to 610*, and 23*/24 hr*, to complete R&S 028191 Purified hydrocarbon*. Esso Research and Engineering Co. Neth. Appl. 290.021 (Cl. C 07r), June 25, 1005 Appl. March 20, CAUlyst 1063; 17 pp. To obtain starting material for isomerization and 1 paraffin alkylation, a miit. of hydrocarbons should be purified__ 9 from alkeoes, aromatic hydrocarbons, and S-contg. cotnpds. Therefore, at first this mixt. is heated to 933-176.7* and the 3 4ft vapor is brought to an absorption zone contg. a Linde 13X or 10X Nvo-Ib./uvgtnLa/ far. 1U.0 169.9 160,9 167.9 179.1 159.1 -batcan 19.1 19.9 19.0 19.1 19.0 U.O (Mp, fMd 692* 669* Ml* 659* 64ft* 647* MrttflBanbmoirt 799 144.7 79ft 133.8 829 149, ft 923 147.4 97ft 149.3 819 149.3 w T*W mti 39.7 39.9 39.7 39.4 U H-4 M44 B3.I MO UM.Sl molecular sieve. So only most of the alkenes remained, which are removed by condensing the vapor and bringing the liquid to production. The process consists in alternative dehydrogenation of steam-diluted *-butenes and steam-air regeneration c/ catalyst. another Linde 10X or 13X molecular sieve at 21.1-65.6*. e P. Vink Iaohexane* by the isomerization of -hexane. I. A. Balashov and E. A. Timofeeva. 0.S.S.R. 172.310 (CL C 07c). June 29,' 1965, Appi. May 18, 1964. Isohexanes are prepd. by the isom erization of *C|H|i on A1C1) and to increase the yield, 0.5- 1.5% Li stearate or MVP oil or TslATIM-201 lubricant is added -- to tbe A1CI). From Byul. Izobrtl. i Tatomykk Zmakot 1965(13), 17. . MHCL 4-Methylpeat-l-ene. Toyo Rayon Co., Ltd. (by Ryoji Nakanisbt and Akihisa Miyake). Japan. 20373C&5). Sept. 10, Appl. March 12. 1962; 2 pp. Dimerization of propylene in all- ^ phatic hydrocarbon in tbe presence of a reaction product of K with ether was described. Thus, a mixt. of 40 cc. heptane, 4 g. K, 2.16 g. auisole, and 033 mole propylene is heated in 100 cc. autodave at ISO* for 10 hr*, to give 0.12 mole hexene composed of 4-methylpent-l-ene 78, 4-methylpent-2-ene 16, 1-hexene 6, and others 1%. Hiroshi Kataoka -- Isomerization of the C olefinic hydroesrbona. P. E. Tulupov and N. G. Polyanskii. U.S.S.R. 172,308 (Cl. C 07c), June 29, 1965. Appl. March 13, 1963. The Ci olefinic hydrocarbons are isomerizrd by heating them on sulfo cation exchange resins. To increase the selectivity of the process and to inhibit the polym- t erization of the olefins, the resin is first hydrated to tbe limiting swelling and the process is carried out at 150*. From Byul. liobrtt. s' Taaamykk Ziakat 1965( 13) 17. MHCL Typical conditions are given in the 2nd table. K. Russo Removal of acetylene* from a mixture of hydrocarbons, znain'v diolefina. Chemische Werke Huels A.-G. (by Manfred Rekf . Ger. 1,196,642 (Cl. C 07c), July 13. 1965, Appl. July 10. 16o3; 4 pp. Addn. to Ger. 1.190,456 (See Fr. 1370,445, CA 62, 144978). According to Ger. 1,190,456 acetylenes can be re moved from a mixt. with diolefins by selective catalytic hydro genation hi the gas phase. The catalyst was composed of 5-50% Cu, 1-50% Cr. and 0.1-50% metals of tbe main group 1 and II of the periodic table in form of their oxides, not reducible by H up to 600*. It *u found now that 0.01-20% of one or more metals of the group VIII and (or) Ag and (or) Zn addnl. to or instead of Cr gave an even better catalyst. The acetylenes were hydro genated in presence of * equimolar amt or even of a great escess of H without reduction of the diolefins. Thus, CuCOs.Cu- (OH),, NiCO*, and CaCO* were brought onto pumice, fixed by water-glas*, and reduced at 200* by H. Tbe catalyst thzzs .ad duced contained 143% Cu, 0.9% Hi, and 13% Ca. A nzr.t. of 95.7 mole-% 13-butadiene. 0.162 mole-% rinyi-, Et- Meacetylene, and 1 vol.-% H was transferred over (400 f pm- L catalyst per hr.). Leaving the reaction oven the mist.' urstnrd 953 mole-% 13-butadiene. Acetylene* could no: b indicated any more (<0.0003%.). Several examples, varyii ae compu. of tbe catalyst and the rates of the gas phase comp- zts are givm in detail. Mr me Pauling Hydrogenation of 1-butene on an Irradiated molecular sieve. James M. Caffrey, Jr. (to Texaco Inc.). 0.S. 3,210,437 (Cl. 260-683.9), Oct. 3.1965, Appl. Oct. 25,1961; 3 pp. A molccu--- lar sieve of the Ca aluminosilicate type, such as Linde 1QA, is ex posed to H for 15 .-nin. tu 2 hrs. at 400-550* at subatmospberic pressure, then y-irradiated with 0.1 X 10* re. Contacting H and 05 to 50 cc. gaseous butene per g. of this adsorbent at 0-100* results In hydrogenation of the butene. L. R. Caswell . Olefin dhnera. Monsanto Co. (by James M. Sdiuck and > Robert G. Schultz). Fr. 1.403,273 (CL C 07c), June 18, 19G5; Butyl chloride. Organization of the State i, -amittcc for tbe Chemical Industry under the State Planning Committre of the Council of Ministers of the U.S3.R. (by B. G 'd.--wW. I. M. Kosinskaya, I. L. Bogatyxev, end S. 1. Cherepanov). U.S.SJt. 172,289 (a. C 07c), June 29, 1965, AppL April % 1963. Buabpcepd. from the reaction of BuOH with HQ in the* presence of ZaCl* at derated temp. To increeie tbe yield end ensure a continuous process, the nrrrru b carried out us an aa- soln. of ZnCIf. From Byul. Itaartt. i Tcturnjkk 7uakm 1965 (13), 13. MHCL U3. Appl. July 12, 1963; 53 pp. Active C is treated with NH| Chlorination of alVynots. Chcmiscbc Werke Hods A.-G. and impregnated with a Co salt of an alkanoic acid or an O-contg. Fr. 1,402,396 (a. C 07g), June 11, 1965; Ger. AppL Aug. A mineral acid, the products are activated at 200-31JO* under an in 1963; 10 pp. DicbloroalkeuoU are prepd. by churinatjon of ert gas to give Co/C. Cj_, a-oUTms are polymerized in the pres-_ alkynols in the presence of HC1 at <--35*. Thus. 226 puts ence of the prepared Co/C tu give liquid dimers which can be used CH;CCH|OH, b. 1U-15*. satd. at -45* and 900 mau srith 2J0 in tbe prepn. of biodegradable detergents; catalysts activated at parts HCl and treated at the mme temp, and tuvisun. with 450-550* can be used to dimerize C;_,, alkcncs contg. an internal 284 parts a yielded 245 parts ClHC:CaCHiOH, bu 80-7*. double bond. The olefins arc passed over tlie Co/C at 0.1-2 and 132 parts CHC!tCCbCH,OH, b,75-95*. Similuly. CH.OH- g./g. catalyst/hr. at 10-50* and 3.5-21 kg./cm.' Thus, 300 g. Ca:CCiaiiQH, b. 130-18*, and CH*OHCC!iCCbCHrf)H, h BPL activated C is treated with 300 ml. coned. NHi, dried 2 hrs. 0 175-85*, are prepd. M Fbrah at 120*, treated with a suin, of 21X1 g. Cm'NO,), dll/) in 250 ml. 33-Bichlo(t-l,l,2,2-tetrafluorop(Opane. Imperial Chemical H,0, dried 3 hr*., Iwatcd in tucua lK lire, at 1 Jo', and activated Industries Ltd. (by Brain G. Dutton and James Raventosi. in tatua at 274*. A reactor is charged with 'XI g. propylene, Brit. 1,004,606 (a. C 07c). Sept. 15, 19G5, Appl. May 15. 1962: 2-4 g. catalyst, and 10 uil. heptane and tin- i ixt. is heated to 3 pp. Process for tlie prepn. of tbe title compd. (I). Ct, at 33 85* in 1/2-1 hr., heated .1 hrs. at h-l*. and coo' d to room temp. __ l./hr. is bubbled through 225 g. HFtCCFsCHtCl in a task under to give 13.01 g. pruduct/g. catalyst as compares, with K.U2 for the a packed glass column suniamnted by u trap cooled with solid Ctx. control. BDPF Tlic mixt. waa kept at the reflux temp, by bradiating with a Itg Catalytic dehydrogenation of w-butenes to butadiene on a vapor lamp for 7 hrs. The product of 4 rani weighed 2k> g. sal nickel calcium phosphate catalyst. Prediction of catalyst life. was Mtxl. by gas pliase dmiiiiatugiapliy tu give 11X1 g. I. b. ., Gutdrich-Culf CIn-inieaU, Inc. thy William I.. Krlil and Duuahl uf 99.7';,', porky. A raLbit iiilialiiig 3'f I in (A fur lu u,Li. ilxs S. M .elver). Fr. 1.105.509 /Cl. It <U/. C ). July. 0, lixif.; /, \%hFt f"r I hr. was anestlH-tized with viry little fall in IJ.al-|ir<-- I'.S. Ai.i-l. ilei. J.: pp. \ . >i .It t is pri|t. cuing. sun- anti n-* v.mli.ic irrexnl.iritivs, lu |iallHtg,*ti.trts' i.tus . t1 - Jll.a 111 at.V.i. .VI'. Ni. I .77..V , l`t>,, small i|u.iiililiis ratio L.C.^ AC^ f**r 1 i. J.l .li.:i, that b 7 hvn- A.C_ is t of Cr/), as a proiia.li.r and lubneanl. lly x-ray analysis of null- iiiiiiiiiiuiu ctnicii. Iiy vi4. tu fully uuvstlirti'e .V11 ( nl the mkv :n- aiiiv.itnl eal.dtsi with the k,, fnqm tiey of Cm. tin- rryslalliiM- I..Ca,istlM-minimum tsmcti. by vul. to kill 5u*. ( of tbe mice with* funds of Ca salts an- uI, ill ill. *I a% nml.u I** Cu/I't),), ami t'.i.* 1(0 miii.). C-iuiimiuMv i atins are: ethvr 19.1:331,OKT. 2.17, - 3231 w>*mic*i Kcurtca VOt. tto, 15*1/ C/y viiF ' . ' activity. C. V. Martiuyan. Biel. Zk. Atmntii 19(8). 39-41 (1064 KArmcnhn). In previoas studies it was Citabliihed that the dccompn. of proteins is accelerated by poisoning with chloro- prene. This process can be interrupted and the protein con tained In cells rapidly restored with hypoeulfite solo, by an tin- known mechanism. Studies made to elucidate the Influence of chloroprtne and hyposulfile on cathepsin ensymes were incon- elusive, and it is suggested that the most important factor in this modification is related to the transaminases. Expts. were con ducted using normal mis (control) and rats poisoned with chtoro- preoe (8 mg./)., 2 hr*, daily, 2-3 months). The activities of glutamic-oialacctic transaminase and glutamic-pyruvic trans aminase were measured by using the Reitman and Frankd method (CA SI, 1808(1A) and arc expressed in Vroblcvski units. The activities of the. ensymes decreased 10-19% in blood, liver, and kidneys and 41-51% in the spleen of poisoned animals. In in vitro expts. the decrease in enzyme activity in normal tissues was4.7-8.4%and in poisoned animals 2.3-7.1%: in the spleen the decrease was 0.*-0.5%. Hypoailfitc also towers the enzymic ac tivity; however, the combination, hyposuifite-chloroprene re- stores it to the initial level and in some cases even a higher level is reached. Chloroprcne does not affect the activity of pyridoxal phosphate. These results lead to the assumption that the in- htbitory action of chloroprcne can be explained by its reaction with the protein part of the enzyme. L. B. Bedighian 1231c Changes In the esterified fatty adds and cholesterol in arum and liver of rata after application of orotic add and hspato- toxte substances. F. Musil atn J. Sucva (Skoda-Werke-Krank- enhauses, Plzen, Czech). FtiU Stiff* Anttrichm. 68(9), 7-48-50 (1966)(Ger). Changes in the serum and hepatic levels of choles terol and esterified fatty adds following oral administration of CCU (0.5 ml./kg.) for the intraperitoncal administration of ethio- nine (250 mg./kf.) to rats were in some cases normalized follow ing oml administration of ocotir add (100-250 mg./Vg.) given ms either a preventive or as a therapeutic agent. CMJG 1232k Acute (mouss ari tat) and short-term (rat) tondty studies on dlbutjIMIetfjfea* pjtt- bispbthalato). D. B. Hall, Patricia Austin, and F. A. crweather (British Ind. Biot. Res. Assoc., C--.nalton, Engl.). Feed CctmH. Toxicol. 4(4), 383-P',lCCoaEng). Acute and short-term feeding studies have been carried out on a sample contg. 80% dibutyl (diethylene gly col bbpbthalate) (DDCB). The intraperitoncal L.Do in both mice and rats was approx. 11-2 g./kg. This dose when given orally was tolerated by both species without ill effect. The toxicity by other route in mice was enhanced when DDGB was adminmeicd in arachis oil (50% vof./vol.). In a 90-day study in rats given dietary levels of 03 (control), 020, 12), and 2.5% DDGB, significant growth retardation occurred in both sexes at alt levels apart from males on 0,25%. This effect was attribut able, at least in part, to reduced food intake, although this effect was less marked in females. There were no hematological changes or effects ot, kidney function. At the 12) and 2.5% diet ary levels, the relative liver and heart wts. in males and the rela tive brain sets, is both sexes woe significantly increased. No pathol. changes were found that could be attributed to DDGB. In view of the effect ou growth at the lowest dietary level of 0.25%, a no-effect love! in the diet of rats for 90 days could not be established for the particular batch of DDGB tested. ____ RCTT 1233t Reaction of hydrezocobalamia with thiols. Norman Adler, Thomas Medwick, and T. J. Poxnanski (Merck Cbem. Dir., Merck ft Co., Inc., Rahway, N.J.). J. Am. Ckem. Sot. >8(21), S018-20(1966)(Ettg). Hydroxocobalamia reacts with thiol compds., as exemplified by glutathione, to form relatively weak 1; 1 inner coordination complexes. Previously reported in consistencies in the generality of this reaction are explained in terms of the simultaneous rok of thiol compds ns complcxing mno reduring agents* RCJC 1234a Neurotoxic effects induced by seriating agents. M. G. Donelli, R. Rosso, and 8. Garattini. J. Phan*. Pharma col, 18(11), 70O-2(19G6KEitg). tn decreasing order of effective ness, dl.tryptophan mustard, n-sareofvxine, glycine mustard, t- sarcolysine, DL-sartolysfae, and alanine mustard produced a typical pattern of neurotoxicity when administered intracere brally to rats. The typical pattern of neurotoxicity included a latency time of about 30--00 min., followed by signs of central stimulation, incoordinate inovenu-uts, and stereotype behavior, and ending with clonic convulsion* ami ncrudoual tonic exten sions. Muunilol mustard, tetrainiiie, cyrio|>l>>spltumidc, and chlorambucil were not ncutotuxic when administered In drwro ri 100 v/rat. Intrapcritoneul drami*tration of Na phenytnin (100 mg./kg.) was ineffective in preventing the murotoxie effects in duced by the alkylating agents, wlienus Na phvnriwbitone showed a dear protective effect. Cysteine anti thiourea (l g./ kg., intrapcritone-xlly) were also ineffective in preventing the ncurutoxic effects. CMJN 1233k Effect of chronic nortriptyline prrtreatment on the acute toxicity of various medicinal agents in rats. 11. It. Meyers, D. O. Kanyudt, and R. C. Anderson (lili Lilly hr Co., Greenfield, Indiana). J. Fkorm. Sci. 55(11), lSIT-UKlfMMXIfag). A method using rats that can be of value is predicting the effects of chronic treatment with psychotherapeutic* oa the acute toiie- ity of other medidnal agents is described. Results obtained by this method showed that nortriptyline, like amitrmtylinc. en hanced the toxicity of rivet cerebral depressants ia an additive manner. Roth of the antidepressive errapds. markedly potenti ated the toxicity of phyiostigminc and to a lesser degree piloctar--- pine. Ephedrine toxicity was significantly antagonized thymricptic pretreatment. The test failed to verily reports tl_ the tricyclic antidepressives dangerously potentiate the toxicit. of alc; or monoamine oxidase inhibitors. Results indicated that a variety of medicinal agents can be med in the nortriptyline treated patient without any problem id significant drug inter action. RCYG 1236r Chlorinated anilines and their sanitary-toxicological characteristics. G. D. Khainuev, Kkim Foktary Vania. Srtdy i ikk Gipcn, Ztmckcwit, Sb., Unco*/ 1965, 108-10(Rtns). Monochloroatutine is used in the production of insecticides and dyes. m-Monochlorounilinc (I) and p-monochl'vroaiuiine (II) dis solve in H,0 (S g./l.), in which they cause an unpleasant taste end odor. The odor and taste perception thresholds were 2.6 and 7.2 fori and 1.5 and 3-6 mg,/l. forU, resp. la a conen. of . 150 mg./l., ronens. are 1I.5anmdgI.I/l.lofwoer rIedantdhe0.B75.Om.Dg../ol.f fowrante.r. Threshold The L.D. values (stomach administration) for I and II, reap., were 1104 and 401 for white mice, llOfand 368 (or white rats, and 750 and 350 mg./kf. for guinea pigs. A 3-month sub-acute expt., conducted on white rats with stomach administrzrion of 0.1 (.Do, level*, roused the formation of mcthrroogictiin and re duced the hemoglobin level and the erythrocyte count. From Rif. Zk., Kkim. 1966(8), Ft. ft, Abstr. No. 81414. MVRK. 1237y Tosktty of ttioerotamide. Z. Hruben, W. Grad man. A. Sfroen, end M. Lubrau (Univ. of Chicago). Lot. 1motet. IS (11), 1748-60(1966KBnt). Thioacetanwle (I), fed to rats in a diet contg- 50 mg./kg. body wt./day fm 5 days, produced high serum lactic dehydrogenase levels and centrolobular necrose* of the liven within 24 hr*.; the enzyme levels dcaoed end the necrotic area* were resorted within 3 days of feeding the diet. Seme degenerative changes in the kidneys, hematuria, and in creased serum urra N and scrum creatlniae levels ocroived within 48 hr*, of treatment. The lethal effete* of the above level of I were correlated with the renal demy. Excess dietary casein hydrolysate, methionine, or guannune reduced the mortality end renal tosirity of I, although these compds. did eot prevent the nuclear and nucleolar enlargement d hepatic crib and of the cells of the proximal convoluted tubule* of the kidney occurring in treated rats. 87 refercnees. RPJN 1238f Poisoning by grass. C. H. Gallagher, J. H. Koch-- and H. Hoffmann (Univ. Sydney). Nm Scicnhit 31(510), 41R^ 14(1966)(Eng). Acute and chronic neuromuscubr dlsordri^^ff occur in sheep feeding on the pasture gras* Phaloris tuboroca^^ This gras* contained 03% (dry wt.) Uyptamine alkaloids. Tissues from sheep undergoing acute primping showed no hbtoL alterations, whereas the brxin and kidneysof cbroaicaBy poisoned anirnsh showed deposits of green pigment, The pigment was noted in the mitochondria tew of the mMbrabi, brafa stem, and spina] cord. It b suggested that thesechanges are related to the oxidative deamination of N^N-dimethyitryptamine and 5-me- thoay-fifJV-Jknethyltryptenilne. The protective action of Co against the chronic form af the disease, reported by others, may be related to the prevention of degenerative changes in nave tissue or to the acceleration of alkaloid metabolism. W. L. Downs 1239p Vinyl chloride; industrial toricrioglc imth. L Grigorescn and Gh. Tfu. Rto. Ckim, (Bucharest) 17(8), 499- 4 501(1966XRom). A hypothesis was pud forward, claiming that g CH,:CHC1 (I) coold react with HA) at the level of the hepatic ad, yielding ethylene mooochlorohydrm, which andd be oxi- died to chloral and. chhmacette add (II). II couM be dfan- nated mch in the urine or be roetabofard further through ami- natioo to glyeocol. An ana), method was developed for detec tion of II fa urine, awumfag that the only other source of 0 could be massive ingestion of wine yeastsr inhalation of triehloro- cthyieue. An aliquot (200 cc.) of mfae, acidified with SO'r HiSO, (2 cc.) b extd. with EtyO (200 ee.), shaking vigorously, and settling far 24 hr*. The ext. b dried (atihyrf. iVajSO.t, cvxpd. to dryness under reduced pressure, and the residue b di- nived fa 50% aq. ale. aria. (0.3 ee.V. Ouc drop d the -Jh- (25-30 jj.) h placed on Whatman No. t paper terips (25 V 3 cm.), drird, and rinaaatngrapbed by nvcentBng lurtkaL mfag as riutaat the mi-t- Nll/)il-E*Olf-lIA> (1:31:4) le a period of 6 hr*. The strip*, dried fa A. ire kept 24 bra- fa a cooed. NH* atm., beated far S min. at Nr', sprayed with O-l1 ninhydrin in MeOH, and drierI. Tht K b indicated by rcrhltsfc- violet *|xils. Fur distinct rKvvlopnu-nt, the strips arv s]ira>id finally with lir;. Cu(N'Oi), (carmine nd sjmls). The K/ at was nuMeJnl with a w4n. *>( 3Kill*g. Il/ce., os O.WI, IJs limit nf seudlivity is 0.1 **. 11, anil b hgnivni by IW Uw if l'- (KO|)i. The extn. nf H from urim- was demorotratrd by treat ing a sofa, of 25 *ig. n/cc. fa uriue asrifavr, cuttfac the R&S 028192