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Ur, T.S. Foloy - New York fir. Paul I-orue - St, Louis Dr. R.L. Jenkins Anniston Usosra. Edger E. Hardy
J,F. Pec X.U. Fll R.P. Loewen
Deoenbor 50, 194?
Celanese Corporation of America Central Iteeearoh Laboratory Dunrnlt, Now Jersey
Ocntleraen:
Dr. L, s. Bimbaua '
As succeeded by Dr, R. L. Jen\lns In his letter to you on Docember 23, wo ere pleeoed to mrlto ebout Aroclor toxloity considerations.
The boat publlshod lnforoetlon bbout the toxicity of Aroclor vapor*
with roferenee to possible daner.e to the liver la in a series of
three ortlolee witten for tho Journal of Industriol Hygiene and
Toxloolopy., The first ertlolo appearing in the .September- 193? Issue,-
Vol. 19, No. ? and the eeoond article publlohed In the February 1938
Issue, Vol, 20, No, 2 were written by C^K, Drinker, K, F. Verrcn, end
0. A. Bonnet and cover only Aroclor <*.460, The third ertlole written
by Dr. Drlnkor alone Is nore complete os It gives information ebout
Aroclors 4455, 1254, 1260 end 5460. -e particularly wish to refer
you to thle article entitled, "Further Observotlons on the Possible
Dyotenlc Toxicity of Certain of t)>e Chlorinated Hydrocarbons with
suerestlono for Permissible Concentration* in the Air of Vorkrooms*,
_sby Ceoll K. Drinker,.The Journel of Industrial Hygiene eDd Toxicology,
Vol. 1, Ho. 5, Kay, 15357
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In this artlclo Dr. Drinker tabulntes the permissible limits of the oompounds in mg. per cubic meter of air In workrooms. The .following date is as. excerpt pertainlnr to peralnslble limit* of various Aroclors:
Material .
Peraiaoibl* Limit Mg, per Cu. jj.
No. 8 Aroclor 4465
''
!
Ho. 9 t Aroclor 1254
.
!
i Ho. 13' Aroolor 1268 '
'> Ho. 14 Aroolor 8460
0.8 0.8 10.0 0.8
From this. It is noted that there Id q mrkod variation la the toxicity of the vajora of different Aroclors. To quote Dr. Drinker, "Aroclora 1268 is almost non-toxiC. TL voporc of the other Aroolor studied ere toxio and should be avoidod. In "cueml, the sore highly ohlorireted biphenyl* sre less toxio then tho lower chlorinated derivativaa, probe-
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bly flu to decreased solubility. Tho chlorinated torpbenyle appear to be more toxle then eorreponding onlorloeted biphenyl#.
iThero the eolfl or solvent method Jo used for tho impregnation of
Aroclors usually only normal precaution or ordinary oleonllnoss of commercial plant praotioo are followed.' Wien tho Aroclors are v. eppliod by hot methods, 300* T. or higher, the workrooms should to voatilotod by intake and exhaust fan of sufficient volume end volocity to remove J.he majority of tho fumes. Whore ever drying even are used, the tupore mt bo romoved. Suggestions obout this
ere given In tho ertiole entitled, "Observations on the Torle Effects Resulting frost Exposure to Chlorinated Nophtbelene end Chlorinated Phenyls with Succeotions far Prevention", by Dr. H, Von Eedel, Dr. Rx. A. Hollo end Dr.'James Denton, publlohod in Tho Rubber Are. Vol. 53, Mo. 5, August 1943. -
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In gonerel, it is believod thot Uo nuxlmn permissible amount of Aroolor vapor in the workroom ie evident to the workmen boeeuso of an irritotine influence on the eye meabrones. Zt therefore beoorews a sc If-revealing slcnnl xrliej; dangerous lovels are reaohod.
If you desire, we will be glfJd to Xrnfl you an instrument which we have with full instructions for its operation to mosaure Aroclor vapors in your workroom atmospheres. Thin would be the moot oorteln aothod to determine that your working conditions sre safe.
In your letter of Docerabor 19 to Dr, Jenkins, you asked whether studios hove bosn node of tho ponr.lble toxicity or dormctitld flue to finished manufactured items oontoinlns Aroclors ss en ingredient.
It was determined by the skin patch text procedure given by Dr. Louis Sohvmrtx and Dr. Senuel W. Dock lr. reprint Mo. 8553 from the Public . Health Reports, Vol, 59, lJo. 17 (April 2ft, 1944) that canvsc painted with Aroclor 5460 and an oil modified nlVyd resin in such a runner thot each square inch of fi.brle eontclnod 10.5 mg. of Aroclor 5460, wo neither a eldr irritant, n or corultir.er.
Tho folloulng ooramorcisl spall cations oro some typical Inrgo eurrent outlets for Aroclors and to our kno-.lefl-e, there is no Instance of . difficulty about toxicity eve!! V.;>i;h in a number of the.vs applications elevated temperatures are uood and consumers come in rather close ' contact with the finished commodity containing Aroolor.
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1. Aetuotlng fluid Tor t.Vrootete. \
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2. Beat transfer medium. 3. Non-notable hy.to. .lie fluid, especially . . '
for die east inn vchlnce.
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4. Adhesive# for "a,ly -ir*.r.-or.;
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5. Vood preservative and sealer trestasnts.
6. Air compressor lubricant.
7. Plasticiser for nitrocellulose, ethyl eelluloee ,
and polyvinylchloride coatings. (In a number of
. applications of ti'in typo the conoumsr comes in
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intimate contact with t) t cooling compositions.
A good exomplc ia eooted beelo of ladle#* shoe#).
6. riaetloixer for I'urlon end Pliolite paints end
eostlngs.
0. Plesticlzcr for wlro inoulotlnc compound#.
10. In trenoforraor# end capacitors.
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11. Aa as impr'.7ont for paper product#.
12. lYeoiure censltlve eealer#.
13. Id fire retardant points end costings.
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14. Inprecnent for textiles.
10. Industrial printing inks.
10. Stop-off looquers for electroplating.
17, Ceromlo, glaze printing..
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18, Plactielzer for usobult conpositlone.
19, la the .manufacture of dontures.
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Booed on our practical experience in the manufacture end sale of ' millions of pound# of Aroclora annually, the point that we would emphasize is that workers should not be expooed to Aroclor vopor# and that the ten working with Aroclora should observe "good house keeping" rulan about keeping tholr clothing and skins free of the materiel and avoid ingestion of it.
Adequate ventilation has proved wiocoocful in keeping the etmoepbere free from harmful amounts of Aroelors around machinery and in plants.
'.Chen you have had opportunity to rive consideration to our above comments, pi coos let us hove your thought# end let us know If we can be of further asslstanoo to you.
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Youra very truly
P. 0. Ponifpus Development Department
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