Document OJy6oB45jk68m6Ra4zVxpQmvM

_ THE MERCK INDEX AN ENCYCLOPEDIA OF AY 994 mnMuiifiit.mil. tti. NINTH EDITION JUN t i 1977 TECHNICAL INFORMATION SERVICES TOLEDO, OHIO 43666 Martha Windholz, Editor Susan Budavari, Associate Editor Lorraine Y. Stroumtsos, Assistant Editor Margaret Noether Fertig, Assistant Editor Published by MERCK & CO., INC. RAHWAY, N.J., U.S.A. II rn^ir^ -4 M CHON MADmi 994 G Ci-nier Atisnfa, Georgia " 845 Asaprol foods: an ingredient in Worcestershire sauce. A 2% suspen sion as repellent against dogs. cats, rabbits, deer. THERAP CAT: Carminative; antispasmodic; expectorant. THERAP cat (VET): Has been used as a carminative, and externally to prevent bandage chewing by dogs. 845. Asaprol. 2-Hydroxyi-naphthalenesulfonic acid calcium salt; calcium 2*hydroxy*l-naphthalenesulfonate, calcium 0-naphthol-a-monosulfonate; calcium 2-naphthol1-sulfonate; 2*naphthol*l-sulfonic acid calcium salt; Abrastol; Calcinapbthol. Cj^H^CaO^; mol wt 486.54. C 49.37%. H 2.90%, Ca 8.24%. O 26.31%. S 13.18%. Prepn: Hagers Handb. Pharm. Praxis Band 2, 204 (Berlin. 1930). 1.5719. Practically insoluble in water; sol tn alcohol, ether, glacial acetic acid, carbon tetrachloride, chloroform, petr ether. LDn i.p. in guinea pigs: 0.0275 ml/100 g. 848. Asarum. Wild ginger; Canada snmkeroot; Indian ginger. Dried rhizome and roots of Asarum canadense L.. Aristolochiaceae. Habit Canada to N. Carolina and Kansas. ConstiL Acrid resin, arom. volatile oil. methyl eugenol. 849. Asazo). a-(Acety!amino>-4-fbis(2-chloroethyhamino]* N- 2- th iazolylbenzenepropanamide; a - aceta midO' pfbis(2-chlorotthyl}amino]- N-2-thiazolylhydrocinnamamide; (thiazo!yl*2)amide of N*acetylsarcolysine; 2*[/>*[bis(2*chlo* roethyl)amino)- N-acetylphenylalanoyl)aminothiazole. C,hi*CLN0,S; mol wt 429.38. C 50.35%. H 5.17%, Cl 16.51%, N 13.05%. O 7.45%, S 7.47%. Prepn: Berlin, Bronovitskaya, J. Gen. Chem. USSR 30, 347 (1960). CICHgCBg Trihydrate, reddish-white, odorless powder. Dec at about 50*. One gram dissolves in 1.5 ml water. 3 ml ale. USE: Has been used instead of gypsum to plaster wines / CICHjCHj 846. Asarinin. Episesamin. CaH,,Ot; mol wt 354.34. C 67.79%, H 5.12%. O 27.09%. Naturally occurring /-form known as xanthoxylin-S in early literature, lsoln from L. (X. ifiguel vai.| Crystals from abs ale. mp 165.5-166.5*. THERAP cat: Antineoplastic. ' lagnesium Industrial Coltonl _____ __ ___ ___ _____ |ordin. Jj Idm. ___ __ __ 1649 (1906); Dieterle er al. Arch. Pham. 269, 384 (1931); Huang-Minlon. Bar. 70, 951 (1937); Kaku et al.. C.A. 32, 9090' (1938). Structuri [WerfR. tfeh. Pharart 277, 33 (1939). Syntl lerou^chechter. Jl Am. Chem Soc. 78, 12 mbergTFischer, BerJ 89, 1230 (1956). Di ic 4ukh Aamin. (q.vJX Stereochemistry of the d-form: Freudenberg, Sidhu, ibid. Fine. Slender, flaxy fibers, resists Tire and most solvents. use; Heat *resistant insulators, cements, furnace and hot inert filler medium (laboratory Sc. commergloves, clothing, brake linings. Caution: lure to the dust can result in mesothelio* ceil carcinoma and adenocarcinoma of the lung after a long latent period. 94, 851 (1961). 851. Ascaridole. i-Methyl-4-(I-methylethplh 2,3-di- oxabicyclof2.2.2]oct- S-ene; 1.4*peroxido*p*menthene*2; Ascarisin. C^^O^; mol wt 168.23. C 71.39%, H 9.59%, O 19.02%. An organic peroxide which constitutes 60*80% of oil of chenopodium. Synthesis from o*terpinene by treat* ment with oxygen, chlorophyll, and light: Schenck, Ziegler, Naturwiss. 1944, 157. Purification: Beckett et aL, JPharm. Pharmacol 7, 55 (1955). /-Form, crystals from ale, mp 121*. [aj|f --118.6* (chlo roform). Practically insol in water; slightly in cold, freely in boiling methanol, alcohol, chloroform, acetone, benzene. Antitubercuiar activity: Ramaswamy. Naturwiss. 44, 380 (1957). dl-Form, mp 134-135". 847. Aaarone. (Ehl.2,4-Trimethoxy-S-(I-propenyi)bentent; 2,4.5-trimethoxy-l-propenylbenzene; o-asarone; asann; asarum camphor, asarabacca camphor. C(JH14Oj; mol wt 208.25. C 69.21%, H 7.74%, O 23.05%. From root of Asarum europaeum L.. Anstolochiaceae by distillation with water. Also found in the ethereal oils of A. europaeum and A. ari/oUum L., Aristolochiaceae and in Acorns calamus L.. Araceae. Isoln: Ganermann. Eggers. Ber. 32, 289 (1899). Synthesis; Seshadn, Thiruvengadam, Proc. Indian Acad. ScL 32A, 110 (1950); Sharma, Dandaya. Indian J. AppL Chem 32, 236 (1969). Stereochemical configuration of asaron and d-asaron: Baxter et aL, Can. J. Chem 40, 154 (1962). 0CB_ tr > H3C - 0CH3 Needles from light petroleum, mp 62*63*. bp 296*. n^1 h3C ch3 Liquid; unstable; prone to explode when heated or when treated with organic acids, df 1.0103; dg 1.0113. mp + 3.3*. bpu 39*40*. [a]jf 0.00. Sol in hexane, pentane, ethanol, toluene, benzene, castor oil. THERAP cat: Anthelmintic. therap cat (vet>: See Oil of Chenopodium. 852. Ascarite. Sodium hydroxide coated asbestos. USE: Absorption of C02 in combustion analysis. 853. Aldepin Pleurisy root; butterfly weed. Dried root of Asclepias tuberosa L., Asclepiadaceae. Habit Ontario to Minnesota. ConstiL Asclepiadin, resins, volatile oil. 854. Asclepias syriaca. Milkweed; siikweed; wild cot ton. Root of Asclepias syriaca L. (A. comuti Decaisnc), As clepiadaceae. Habit Canada to North Carolina and Kan sas. ConstiL Asclepiadin, asclepion--a bitter principle; tannin, volatile oil. 855. Ascorbic Add. Vitamin C; L-ascorbic acid; L-xyloascorbic acid; 3-oxo*L*gulofuranolactone (enol form); L-3-ketothreobexuronic acid lactone; antiscorbutic vitamin; cevitamic acid; Cebid; Cebione; Cantaxin; Cevalin; Cevatine; Cevimin; Cevitex; Cipca; Cebicure; C-Vimin; Cevitamin; Page 110 Consult the cross index be/ore using this section.