Document OEy3gbZYLBrdOrMZab3yLajoM

ATTACHMENT TO LETTER OF JANUARY 30, 2002 3M FLUOROCHEMICAL SUBMISSION Back to Main Menu TOXICOLOGY, EPIDEMIOLOGY AND MEDICAL SURVEILLANCE STUDIES PFOS Perfluorooctanesulfonate Repeat Dose Studies 1. PFOS 6 Month Monkey Study a. Final Report, 26-Week Capsule Toxicity Study with Perfluorooctane Sulfonic Acid Potassium Salt (PFOS; T-6295) in Cynomolgus Monkeys (Covance Study No. 6329 223), 3M Reference No. T-6295.7, January 11, 2002. [Note: the analytical report to accompany this study was included in 3M's December 22, 2000 submission. It appears on CD #3 of the fluorochemical submissions, where the December 2000 submission begins on the fifth page of the index.] 2. Two-Year Bioassay a. Final Report, 104-Week Dietary Chronic Toxicity and Carcinogenicity Study with Perfluorooctane Sulfonic Acid Potassium Salt (PFOS; T-6295) in Rats (Covance Study No. 6329-183), 3M Reference No. T-6295, January 2, 2002. b. Analytical Laboratory Report, Determination of the Presence and Concentration of Perfluorooctanesulfonate (PFOS) in Liver and Serum Specimens of Crl:CD(SD) IGS BR Rats Exposed to Perfluorooctane Sulfonic Acid Potassium Salt (PFOS T-6295), 3M Environmental Laboratory Report No. TOX-002, Laboratory Request No. U2121, 3M Reference No. T-6295.4, February 21, 2001. N-Ethyl FOSE alcohol N-methyl perfluorooctane sulfonamidoethanol Repeat Dose Studies 1. 2 Year Bioassay a. Final Report, 104-Week Dietary Carcinogenicity Study with Narrow Range (98.1%) N-Ethyl Perfluorooctanesulfonamido Ethanol in Rats (Covance Study 6329-212), 3M Reference No. T-6316.1, December 13, 2001. Back to Main Menu ATTACHMENT TO LETTER OF JANUARY 30, 2001 3M FLUOROCHEMICAL SUBMISSION b. Analytical Laboratory Report, Determination of the Presence and Concentration of PFOS, PFOSA, PFOSAA, EtFOSE-OH, M556 and PFOSEA in Serum and Liver Samples of Crl:CD(SD) IGS BR Rats Exposed to N-Ethyl Perfluorooctanesulfonamido Ethanol, 3M Environmental Laboratory Report No. TOX-001, Laboratory Request No. U2103, 3M Reference No. T-6316.1, June 6, 2001. c. Analytical Laboratory Report, Determination of the Presence and Concentration of PFOS, PFOSA, PFOSAA, EtFOSE-OH, M556, and PFOSEA in Serum and Liver Samples of Crl:CD(SD) IGS BR Rats Exposed to N-Ethyl Perfluorooctanesulfonamido Ethanol, 3M Environmental Laboratory Report No. TOX-003, Laboratory Request No. U2104, 3M Reference No. T-6316.1, June 6, 2001. Teratology Studies 1. Two Generation Rat Reproduction a. Amended Analytical Laboratory Report, Determination of the Presence and Concentration of PFOS, M556, PFOSAA and PFOSA in the Liver and PFOS, M556, PFOSAA, PFOSA, and EtFOSE-OH in the Sera of Crl:CD BR VAF/Plus Rats Exposed to EtFOSE-OH, 3M Environmental Laboratory Report No. TOX-012, Laboratory Request No. U2095, 3M Reference No. T-6316.15, May 31, 2001. [Study and initial analytical report submitted December 22, 2000 on CD #3.] PFOA Perfluorooctanoic acid Repeat Dose Studies 1. PFOA 6 Month Monkey Study a. Final Report, 4-Week Capsule Toxicity Study with Ammonium Perfluorooctanoate (APFO) in Cynomolgus Monkeys (Covance Study No. 6329-230), 3M Reference No. T-6889.2, December 18, 2001. b. Final Report, 26-Week Capsule Toxicity Study with Ammonium Perfluorooctanoate (APFO) in Cynomolgus Monkeys (Covance Study No. 6329-231), 3M Reference No. T-6889.3, December 18, 2001. c. Analytical Laboratory Report, Determination of the Presence and Concentration of Perfluorooctanoate Fluorochemical in Liver, Serum, Urine and Feces Samples, 3M Environmental Laboratory and Centre Analytical Laboratories Report No. TOX-226, Laboratory Request No. U2782, 3M Reference No. T-6889.3, June 11, 2001.