Document OEn9L6n81LMDvjNMmLDKYo8Bv

.Company Sanitized. Does not contain TSCA Cl AR226-2846 REVISED m Material Tested l. du Pont de Nemours and Company Haskell Laboratory for Toxicology and Industrial Medicine HASKELL LABORATORY REPORT NO, 694-75 Haskell No. Sample Ready for Testini; Other Codes Material Submitted hy __ Organic Chemicals Departoratory .PRIMARY SKIN IRRITATION AND SENSITIZATION TESTS ON KHTTTOA m e iPKSEi - shoulder sklu of 10 dl. r i y i n t - n i i *b t iy * . <~o.o5 ..Ch . t on t h e U a v e d Intact dermal injections was given, one each w e e k over a three w ~At, na 4 a Potent*a l> a series of four sacral intra- (ut./vol.) ,, test material in sa!" e. l o l W n a U ' 7 T 'h i" " 1 " " '1 " - 1 1 of a K solution Citation by applying, and lightly rubbing in, 1 dron ( ~ 0 05 mil " "`i ^ `I*? ,nl"al" Here <=l" llnged for aensi- (wt./vol.) of test material in distilled water on the s h a v e / ^ t J L f ial 8 received and a 10% solution guinea pigs received similar applications at the time nf ehfii * * shoulda* fikin* A eru P wf 10 previously unexposed reactions on skin of similar age. f challen8a to provide a direct comparison of the challenge (10 Animals - In. Avg. Wt.'= 533 g Final Avg. Wt. = 729 g) -- Control Areas for Challenge Teat (10 Ne w Animals - Average Wt. = 701 g) Concentration in distilled water Primary Irritation Test 24 Hours 48 Hours Challenge Test 24 Hours 48 Hours Sensitization Response Ratio** 100% (undiluted) 5^ > 1 neg. 9* 1 neg. j`*+ , 4+ 4++, 6+ 10% 10 neg. 10 neg. 10 neg, 10 neg, 100% (undiluted) 43+*++,, 67++ 10% 10 neg. 10 neg. * Reaction Code + 44. -1 I1 j, . .. ~ - . _________ _ V ?** Sensitization is defined as a significant scor^incre^pb^ 1 " erythema Plu edemal +H-H- = necrosis, amount applied initially or on t S concwrent controls! challene over the response expected from the same gompany Sanitized. Does not contain TSCA Ci 1 *v_X' Q0RPEC7ED page 2- - f v m a r y : W B B H F p r o d u c e d mild to moderate irritation when tested on shaved pigs using the material as received (100%) and a 10% solution in distilled wlte^ intact skin of male albino guinea challenge; however, this material is a skin irritant. All skin contact with thi^ No sensitization was observed at skrn contact occur, wash off promptly with water. ntact with this material should be avoided. Should Report No. 694-75 Date Issued : November 20, 1975 Report by: Approved by: <?. 5 TJanqI?''- C . oodman Treechnician U). (/Raymond W. Morrow j Chief Dermal and Ocular Toxicology Section