Document OEQVR1eYdGBYD20MDzZ7brazX

Mr. S.D. Kirtoh Bordsn-Arabol Co. 103 Foster street Peabody, Massachusetts 01960 Our Nr. w.S, Clark haa lnfonsed m that you aro daalroua of obtaining toxlolty data for Aroolor 1291 and Aroolor 5*60. The data that are available for theae two products aro aa followss Aroolor 1221 Aouta Oral LDgri - Rat - Undiluted sample - 3980 ag/kg. The aaaple wasolassed aa alightly toxic, Aouta Minimi Lethal Soda * Skin Absorption - Rabbit - ClioDed Intact skin - areator than 2000 but loaa than 3160 ag/kg Tha Maple waa claaaed aa slightly toxie. Subacute Skin Absorption - Daily application for 20 days of a 12.59 solution in corn oil at 150 ag/kg/day No untoward reactions 200 ng/kg/day - Weakness, lassitude, and loss of appetite 300 ag/kg/day * " " There were no deaths and the haaatologlo atudlea and urine analyses at all dose levels were ooeparable to the controls, arose and aioropathologie findings in the saorifioed test anlmls revealed no significant difference free that of the controls. This is all of the lnformtion we have on Aroolor 1221. We would recoon*nd as a natter of good practice mohanioal exhaust ventilation if the aaterlal is to be used at elevated temperatures. Aroolor 5460 This produot appears to be quite inert physiologically. The oral LDco in rats was found to be 19.200 ng/kg and rabbits survived doses up'To 7,9*0 ag/kg when applied to the elan. In both cases the sample was tested as a 3311/3* solution-suspension in corn oil. In 90-day OSW 018317 STLCOPCB4004861 2 oral studies in rats, there were no adverse effects fro Aroclor 5460 When it was Incorporated in the diet at 100 and 300 ppm. In leghorn chickens, 500 ppm in the diet showed no effect except slightly reduced rdte of growth in the study of 18 weeks. Based on the animal toxicity studies and the physical characteristics, it would not appear that the use of this produot should Introduce any serious hasards. We would recoasaend as a matter of good practice meohanloal exhaust ventilation if the material is to be used at temperatures where it would be molten. Slnoerely yours. WHH/ebv oo) J.H. Oannon Kverett W.S. Clark St, Louie William H. Hunt, fh.D. Toxicologist Nsdloal Department DSN 018318 STLCOPCB4004862