Document OEBGELZ5XGdZ0mD0k2Rk67bYX

(I 4.vy, 10/ li {.ILihl S I* MCnflhi AND Att>rA(.i <94114 PAG! 23* MNNfOY C L HlMltTHlmCtl ITUMf/ VftHO*U*XA 4 f )*NCH# ft f CAlANOdA J C 1h( UPAIOGfNIC PtMfNTlAL 0^ CAP IAN FaL^ET 4NO OlffXATAN/ ABSTRACT HAMSTER *.HJ4f MONKEY R4R0II RAT FUNGICI01S -2429041 mo*/ mor) A ACE 2*W*0 MARCUS M k BECKER 0 A THE fye a TARGET ORGAN AQA METHYL MERCURY tt * AT OGE NE $ I S / ABSTRACT A At *U05*)4J FACE 24l<-2t2 NOS It* M 0 JR JANSON5 A A FATE Of NICOTINE IN IhE MAT EC HIS/ ABSTRACT ADull TOXICITY -94HJ FACE 7*1 NAN0A V NANOA A AN AUTO AAOiOCRAPHlC STUDY Of PRI000NMUM IN OSTEOl AThYAISM/ A0ST4ACT RAT ANtNO ACETONITAIL! SULFATtD HUCO POl* $ACtHARiDES PAGE 2*3 NOlEN C A 0UEHI.EA E V GUI A C 60LOENTHAL 4 I The Effects Of tAI SOOJUH NITAlLO TA( ACETATE ON C*DNI\* AND NfTMYL MERCURY TOAICITT AND TERATOGENICITY IN RATS/ A1STAACT ABNORMAL FETUSES TV+OAJ* *1400*141 *0*4US PACE 244 OAKltV C P SHfPARO T H POSSIBLE TERATOGENICITY Of HEXACHLOROFmENE IN AATS/ ABSTRACT CLEFT PALATE -70)0* FACE 2*4 ARTY I H |K RING C T C . EFFECT OF AM|nO PRQPtQNITRILI ON COLUMN CROSS THE SECONDANY PALATE OF f*E RAT/ abstract mm FACE 249 SFVKfA 4 A LINN INC IN SUBTLE CONSEOUENCES OF METHYL MERCURY EXPOSURE/ ASSTA4CT HOUSE NEUROLOGICAL INPAIRNENT CONGENITAL FOISONINC -l*0*)4l FACE *47 ANN FAAAStTOL HUN CONF 4* (VSUFFU. l*7l KUASTAI f FOSSI0LE REPERCUSSIONS OF NICROIIOLOGICAL CONTROL ON VERTEBRATES THE CASE OF VIRUS MSEC BIOLOGICAL INSECTICIDES/ FACE 177-100 UNO TECH RfP SCR ATS. INTI UNO EXPERT COMMITTEE ON INSECTICIDES I0TH REPORT/ PUSLIC HfALlH FE$T|C|0ES PAGE 1-20 MEAN 4 100L I* ill. rn 2001 >004 2Q0S CH*0< I CHONG V AH4A H NUN H POLLUTION OF HAN RIVER SEOUL KOREA/ A0STRACT RACTERIA METAL FACE MS CHO R NA K POLLUTION OF LAKE tUI-AN COREA/ ABSTRACT PLANKTON FAUNA FACE 1*4 CHONG V RANG N FFfiCT OF ALKALI MffAL ION ON DEVELOPMENT OF DROSOFHtLA-flELANOGASTER/ ABSTRACT sodium chloride POTASSIUM CHLORIDE CALCIUM chloride MOLTING -106*1924 t**Tl4* *74*7*07 PAGE IAS ******#' ****** CIOL RIMDSCH 10 (11. 1*72 VON OCRTICN 4--A NARINE POLLUTION A PAO0LI" Of MARINE BIOLOGY/ PESTICIOE HEAVY METAL FETROCHfMtCAL HASTE HATER RADIOACTIVE FALLOUT FACE 1-10 scMNfcie g USE ANO RC0U1RENINT OF ANINO-ACIOS IN INSECTS/ HCNOltnFh EN2VME TOXICITY D ISOMER FACE *0-** health dull (EDIN0I 10 (2). |0T2 EL 14 4-JQMt S * F 0aCTR|AL ACCO P?l50NlNC IM t4ltCHVES SALM(MFLLA STAPHYLOCOCCUS clos tr to IUM-PERFRINGENS toxin PRODUCTION PAGE ID-Ill V H 0 INOALO HEALTH ORGAN) CmAON 2* IT). 1*72 / 44ft HMft AftftlllVtS IN RAN? 0171)09/ human PI SI1C 101 Al V JUUt S Of tUMMCATION NFChANIVMS FACE 119-11/ NAS* TECH 04 IIP U 110447). 1071 SMITH J m tftO V L M1CAOOACANISH SAMPLE DEVICE/ A1A POL U/M ON NO FACE OEAHATOLOGICA I0ASELT 141 19). 1*70 NATIA J F OOEGLAS N N G ACUTE VITAMIN A POISONING/ ABSTRACT NUNAN FRIED NALUUT LIMA SAIN OE SOUAMaTION -AI2A* FACE tU-Mf NAT HEN BIOL 111 120) l*Tl 2012 OEM*AM R l TOXICITY OF TlSSUC CULTURE NCOIA UFQSCO TO FOLV VINYL CIN. DA IDE PLASTIC/ NOTE CHICK EM*VO 0062142 FACE IMt SCI FROG OECOUViRTC 142T. 1*70 RANAOE F 0IADS FCSTICIOES AND OtAtN/ POLLUTION PACE 24-SI SEN IN NEMATOL T II). 1*10 NINES J o 6*49SO 4 A THE SI0ERO CLASTIC ANE|AS/ /MAN HEREDITARY ACDUIAEO TOXIC DRUGS CTHVi ALCOHOL LEAD NUTRITIONAL FVRIOOXIhE RESPONSIVE ANEMIA *7*)**2L *44179 PAGE **-104 OOMN EARTH 20 111. 1ST! LING H L RESIDUES IN RiLl AND NEAT AND SAFETY TO LIVESTOCK PRQN TH0 USE OF PHtttXV HERBICIDES IN PASTURE AND RANGELAND/ CATTLE SHEEP FACE 12-10 | AIR2TL FORTIUQ ** ini. i*72 ifNAD A CONTRIBUTION TO EVE INJURIES CAUSED V EXPLOSIVES/ HUNAN FACE **7-4*4 4 FOCO SCI SA Ml. 1*71 AUNTA U S ALUR N 0 NAV|NKURVf S S LEhIS N F SPOILAGE UNITS OF R4OURI2E0 0OM04V DUCK MAIPODON-NEHfREUS/ `NOTE BACTERIA CLOS1MOIUM-0Q1ULIHUN FACE 0)1-012 TlHARI N F NAXCT R 0 IMPACT OF LOV DOSES of GAMMA RaOIAHON A NO STORAGE ON THE micro flora op gpounq rco meat/ NOTE BACTERIA VECTOR FACE IIHI4 Rfv M0 ) J 9 4)1. I A 71 CIAAUO F DISCUSSION 0* OCCUPATIONAL HEPATITIS/ human INFECTION TOXIC SUlSTANCfS PAGE 2*1-247 GIRAUD F SOME THOUGHTS ON ALCOHOLISM }N TMf lOI*-<I-ChCR DEPARTMENT In F**ici PAG! *4*-2Sl OLI 4951 'WJ-FJ. NOT -9 no 313 [March. 19731 The 1st pn|M'r rovers |M*sllrttti*s ami thrlr t*tmtiUnitlim t I'hriulral epidemiology, (ollovuM hv a dtsvussion on Ike Iwvkr.i miml *>i the D pharmacology of DDT, The next &<-viral articles describe problem* of O prevalence of pesticide residues in humans, an epidemiologic applies* P tlon of the study of DDE levels in whole blood, transplacental passage X of pesticides, and correlation of prematurity and DDE levels in fetal Z. whole blood, Next, a survey 1$ included on DDT and DDE in blood samples of occupationally exposed workers, followed by a paper on levels of DDT and DDE In blood and DDA in urine of pesticide formulaton following a single extensive exposure. The next several papers discuss the following topics related to the epidemiology of DDT: DDT and DDE In blood and DDA In urine of men exposed to 3`" DDT aerosol; effects of anticonvulsant drugs on DDT residues in man: drug and environmental effects of DDT residues in human blood; comparison of whole blood DDE levels and adipose DDT residues in man; and the effects of phenytoin on human residues of DDT and dieldrin-a com* pendfum. The next paper, DDT in man, presents a summary and re* view of DDT investigations and their potential impact on the under standing of chemical epidemiology, followed by a paper on a simplified method for analysis of DDT and DDE in blood for epidemiologic purposes. The final 2 papers discuss reproducibility of micro-Mills procedure for pesticide residues In fat, and determination of DDT mod metabolites, including DDA, in human urine by gas chromatography. The book ends with a related bibliography and a list of contributors to this volume. Selected papers will be indexed in BlQRESEARCH INDEX.-W. K. M. 2693. CARP, E [Ed.], International Conference on the Conserva* tlon of Wetlands and Waterfowl, Ramsar. Iran. 30. Jan. 3. Feb. 1971. 303p. DIus. International Wildfowl Research Bureau; SUmbndge (Glos.), England. 1972, Paper.--This book sets out the text of the Final Act at the Conference and contains a summary record of Its proceedings. The need for a wetlands convention was felt In 1962 at the International Conference on Wetlands held in France. There, it Hi decided that a list should be compiled of European and North African wetlands of international Importance. This final text of the convention is therefore the result of 9 yr of careful study and inter* national cooperation among scientific and legal experts of a great number of countries, and several international organization*. The conference adopted 11 recommendations for consideration and ap propriate action involving the following topics; conservation of the Wadden Sea, northwestern Europe; conservation of Thjorsarver, Iceland; conservation of North Bull Island, Ireland; conservation of Lakes Ab-f-Istada and Dasftt-e-Nawar, Afghanistan: conservation of the Medway Estuary, England; oil pollution; pesticides: promotion of wetlands research; promotion of hunting research and education; African wetlands; wetlands and the Man and the Biosphere Program. The book will be of interest to individuals and agencies Involved in the Conservation of wetlands. Selected sections will be indexed in BIO RESEARCH INDEX.--W. H. M. 2694. OGLESBY, RAY T.( CLARENCE A. CARLSON and JAMES A. MC CANN [Ed.]. River ecology and man. Proceeding* of an interR national Symposium, Amherst Massachusetts, June 20*23, 1971, T xvli + 4WpV Dlus. Maps. Academic Press; New York, N,Y. U.S.A.; W London, England, 1972. Pr, Si 1.50.--This book contains sn Integrated Z series of reports by scientists, engineers and social scientists on rivers and man's interaction with them, information included presents descriptions of the flora, fauna, chemical composition and geomorphometry of rivers; case histories of specific rivers throughwt the world; full discussions of the effects of various river uses on morphometry, discharge, and sedimentation; detailed analyses of the Impact of heat, radionuclides, pesticides, and industrial wastes on river ecosystems; and the eeonomte, environmental, and political implication of multiple use of rivera. The content begins with a section describing what t river is, including a geomorphic and chemical overview, a zoological,description and plant ecology in flowing water. Ibe 2nd section, uses of a river--past and present, cover* man's Impact on the Columbia River, a study in water quality management on the Delaware River, man and the Diineis River, a case history of the Nile River and the River Thames and the uses of the Danube River. The 3rd section, effects of river uses, covers the following topics: regulated discharge and the stream environment; morpho metric changes; sedimentation; a comparative assessment of thermal effects in some British and North American rivers; effects of pcsti* cldes and industrial waste on surface water use; radionuclides in river systems; and nutrients. The final section, rationalization of multiple use, discusses multiple use of rivers and of river systems and political aspects of multiple use. The book ends with a summary of the papers presented at the svmposuini. Selected papers are in dexed in BJORESE/RCH INDEX. Yol. 3.--W. H. M. 2695. 2ARKCWER, A. and W. MORGES. fDep. Vet. Sci., Pa. State Unlv., University Park, Pa, 16802, USA.I Alteration m anti- body repone induced bv carbon inhalation: A model sistem, INFECTIMMlfei 5(6h 915420. Ulus. 1973"the immune re (pom. In mice to antigens [Ac] given by l.p., i,v.. and inhalation route* tu compand in control and C-dust exposed mice. The A 3693-2701 n>>t pronounced effect, a decree In antibody (Ab]-formlnn cell* and aerum agglutinin titers, was observed when the C-trented ani mals were Immunized with Ay in the form of aerosol. Similar re inIt. were obtained when the Ax were administered by l.v. or l.p. route. In contrast 4-days of preexposure to C'dust Increased the . number of Ab-formlnft cells in the mediastinal lymph nodes. This effect was transient and was not significant when the C pr.-exposure was continued for IS days. 3696. MEYERSON, LAWRENCE B. (Irving Med. Prof. Village, 3101 MacArthur Blvd., Irving, Tex. 75061, USA.) and GERHARD C, MEIER. Cutaneous lesions In acrooetcolyels, ARCH DERMATOL 106(3): 324-227. Illus. 1973.--A patient with idiopathic acroost.olysis had unique papular shin lesions. Evidently, similar lesions were previously mentioned only In connection with ac roosteolysls seen In vinyl chloride processing, snd a dstalied description 0i these was not noted in the Utsnture. q 2. 3697. LEE, RICHARD F., RICHARD SAUERHEBER and A. A. BENSON. (Scripps Inst. Oceanogr., Untv. Calll., La Jolla, Calif. 92037, USA.) Petroleum hydrocarbons: Uptake and discharge bv the " marine mussel Mvtllus edulls. SPENCE WASH) 177(4046): 344- z 346. 1972.--The common marine mussel M. edulls was observed to rapidly take up mineral oil, [ 14Cpieptadecane, 1,2,3,4-tetrahydronaphthalcne, [l4c)toluene, [14cNaphthalene, and [3H]3,4-benzopyrene from seawater solution. This species of mussel did not metabolize any of these compounds, and transfer of the mussel to fresh sea water, after exposure to the hydrocarbon In solution, resulted in the discharge of most of the hydrocarbon, although significant amounts remained (between 1 and 400 micrograms per mussel). The nontoxic paraffinic hydrocarbons mineral oil and heptadecane were taken up (10 milligrama per muaael) to e much greater extent than the aromatic hydrocarbona. (3-30 micro*rami per muasel). 3699. ZAWIRSKA, BOZENNA and KAZIMIERZ MEDRAS. (uL Mirclnkowtktego 1, Wroclaw, PoL) Morphology and biological activity of transplantable lnterstltloma testis induced with lead acetate. ARCH M IMMUNOL THER EXP 20(2): 343-266. Illus. 172.--Transplantable lnterstltloma tettit, Induced in Wlstar rata by prolonged feeding of lead acetate, showed discordance between a morphologically benign structure and the tendency to extensive metaxtases, mainly to the lungs, lymph nodes and liver. Its hormonally determined growth caused nonneoplastic and neoplastic proliferation In the hypophysis, adrenals, thy roid, parathyroids and mammary glands. Changes In the genital or gans of males and females Indicated hormonal, especially feminizing, activity of transplantable lnterstltloma. Interstitial testicular and ovarian calls reacted differently to hormonal aamuiL 2699- CLADEN, R, (Robert Botch GmbH, Tech. Zentrum Forach., D-7016 Gerltngen, West Ger.) Die Besttmmung cancerogener polycycUscher aromatlicher Kohlenwasseratotte tm Krafttahrzeugabgas durch Saeulen-Chromatographle. fThe determination of carcinogenic nolvcvcUc aromatic hydrocarbons In automobile exhaust eases by column chromatography. I CHROMATOGRAPHIA 6(4): 236-241. Illus. li72. | EngL and ft. xumm.)--A process Is described (or de termining 12 polycyclic hydrocarbons in automobile exnauet gases by separation In a chromatographic column and subsequent quantitative UV photometry- In contrast to other methods, no special purltieatlon of the condensed exhaust components la necessary, the solution of the test specimen In cyclohexane being treated with a potash solution to remove acid components. The chromatography is carried out tn a Sephadex LH 20 column with Isopropanol as the eluting agent. The un wanted exhaust gat components are eluted before the polycyclic hydro carbons to be determined, the latter being distributed between 8 frac tions, The particularly Important benao(a) pyrene forms a fraction by Itself and Is well separated from bunzo (g, h, t) pcrylenc, which pos sesses an extremely similar UV spectrum and could Interfere with the determination of benzo (a) pyrene 11 the separation were Imperfect, As an application of the method, the separation and quantitative deter mination of polycyclic hydrocarbons In the exhaust gases of a small single-cylinder test engine Is demonstrated. 2700. KELLEN, J. A, (Dep. CUn, Dtochem., Banting Inst., Unlv. Toronto, Toronto 181, Ont., Can.) Failure of transelancental tumourinduction tn ran bv 7,12-dlmethvlbenz(o) anthracene. RES COMMUN CHEM PATHOL PHARMACOL 4(1): 135-140. 1972.--Prenatal exposure to 7t2*dimethvlbeM(a)anthracene (DMBA), Injected 5 day* be* (ore or after mating Spnirue-Dawley rati, (ailed to induce tumors In hr nffrprter during an observation period of 200 dav*. Pregnant and subsequent lactation protected the mother rats from rumor induction. The possible mechanism* ol this protection were discussed. 2701- BAUER, U (Pathol. Inst., Unlv. ErUngtn*Nuernberg, Krznkenhausst. 8*10, D-8520 Erlangen, West Ger.l, A* H, TULUSAN and E, 0 Ml'ELLER. Uitrastrurturai chances produced by the carcinogen, ifla- y toxin Bt, In different ttxnuof. VIRCHOWS ARC11 A11T B ZELLPATHOL 2 l0(4): 2,5-205. Illux. 1072.--In the present comparative study, tissues OLI 4952 J 2780-2791 J-Y [Vol. 2 NO. 3) 222 .. i.--i..*-a. w - a * - lj SO 0 2 0 ----- ,-ewksfcmu.n A i . ..-> .hw .. 2780. BLUM, KTNNI YH (Hop. Phnrr.mi'Ol.. Uiuv. T**x. MH. Srh.. 2 San Antonio, Tex., USA.). JACK F. WALLACE, RALPH S. RYF1ACK and IRVING Cl'LLF.R. DirUunofominc: A vr i^^;rmst> antagonist to < lhrmoK EUR .1 PHARMACOL 19(2): 213-222. Ulus. 1972.--lJietAnjioljjiiii'.*'-rutin (|>R) 'uni riimcUioxY?Utvl.umnc-ruiiji (DMR) were studied fnr u.oir eifcctsyn cthajiul-uidueed sloen time in mice. Tne DR-cthonoi curve was shifted to the ncht of the saline- ethanol curve indicating a DR protection against ethanol-induced sleep. Blood- or brain-ethanol levels were approximately equal for both treatment conditions suggesting that DR's protective action was not due to a lower blood- or brain-ethanol level. In contrast, the DMR-ethanol curve was shifted to the left of the saline-ethanol curve indicating an enhancement of ethanol-induced sleep time. This action of DMR Is probably not due to an effect on ethanol metabolism, since no signif icant difference was found in blood- or bram-ethanol levels in this group relative to the saline-ethanol mice. Attempts to demonstrate antidotal activity for DR were unsuccessful in that treatment of mice with DR alter ethanol administration prolonged sleep time, U is suggested that diethanolamine acts as a weak agonist-antagonist to ethanol in the CNS, ' 2781., MC QUEEN, C. (Dep. Clin, Pharmacol., Med. Res. Counc. p N. Z,, Umv. Otago Med. Sch,, Dunedin, N. 2.), DIANE OWEN and D. G. y FERRY. Effect of phenvtoln and other drucs in reducing serum DDT * loveIs, N Z MED J 75(479): 268*211, Ulus. 1972.--Patients on long-term anticonvulsant treatment with phenyiom (diphenvlhydantoin) have markedly reduced blood levels of DDT-denved materials. Establishment of reduced equilibrium levels appears to take some 12 mo. Although phenytom is especially effective, long-term treatment with a wide variety of other therapeutic substances also reduces blood levels of DDT-denved material. Possible mechanisms determining the reduction are discussed. 278G., GOODWIN, JOHN W, (Day, Ziromermann, fnc., Lone Star Div,, TexarLaiia, Tex, 75501. USA.) Twenty vonr* h:indlint* TNT in a sholl^loadLnn plant. AM IND KYG ASSOC J 33(1). 41-44, IIlus. 1T2.--Li the handling of TNT within the munitions industry, human exposure to this substance cannot be completely avoided. The goal of a Preventive Medical Program is to prevent such exposures from causing any permanent damage to workers, Exhaust ventilation with wet scrubbers, use of protective clothing, mandatory practice of good personal hygiene, and careful medical supervision have combined to accomplish this goal. The use of the Thymol Turbidity Test in such a program was a valuable Indicator of liver malfunction. q 2 2787, KRAMER, C. G. (Dow Chem. Co., Midland, Mich* 48840, USA*) and J. E.MUTCHLER, The correlation of clinical and environmental measurements for workers exposed to vinyl chloride. AM tN'b HY6 ASSOC J 33(1): 19*io. Illus, !6U."-A method is described lor the statistical consolidation and correlation ol environmental measurements and clinical findings using as an example a croup of healthy male workers exposed routinely to vinyl chloride for periods up to 15 yr. Retrospective in nature the study reveals several statis tically significant effects from chronic exposures to vinyl chloride and traces of vinylidene chloride. O Z 27*8. EL-DAXHAKHNY, ABDEL-ARK and YASSIN M. EL-SADDC. (Dep. Occup. Health, High Inst, Public Health, Alexandria Univ., Alexandria, UAR.) Lead in hair among exposed workers, AM IND HYC ASSOC J 33(1 J: 31-54. lUus. 1972.--In a study performed on 67 Pb exposed workers, a correlation was found between levels of Pb in hair and the biochemical and clinical findings, A Pb level in hair of more than 30 ng/g could be considered as a sign of excessive Pb level. 2782., JONES, R. D. (phann, Div,, I. C. U Ltd., Alderley Park, ' M Macclesfield, Cheshire, Engl,, UK.), B.T. COMMONS and A. A. | O CERNDC, Blood lead an'* carbcrvhaemoglobin levels In London taxi U drivers. LANCET (NORTH AM ED) 2(7772): 302-303, 1972.--Among ; Z TO London taxi drivers the mean blood-lead was 23,7 yg/100 ml. There was no difference of statistical significance in the blood-levels of smokers and non-smokers, nor between the blood-leads of night-shift > and day-shift drivers. Carboxyhemoglobm levels of smokers ; were significantly higher than those of non-smokers, and the levels ! were significantly higher in day drivers than in night drivers. * 2783. MC INTIRE, MATILDA S, and CAROL R, ANCLE. (Dep. M Pediatr,, Univ, Nebr, Coll. Med., Omaha, Kebr, 68105, USA.) Air 1 lead: Relation to lead in blood of black school children deficient in flucose-6jphoson:itc dcnvcrocenase. SCIENCE (WASH) 177(4048): 20-522, Ulus, HT2.--Black cnildren (44) at 2 elementary schools ! within 0,7 mi of a battery plant had significantly higher (P<0.01) concentrations of Pb in their bloods (34.1 9.7, ug/lOOmm, mean * ! 5D) than 122 students (26 J + 7.1) at 7 schools 1-3 ml distant; 5 mol 1 later there was a comparable difference between red cell Pb values i (54 J + 18.5 vs. 37,4 * 12.6). Among the blacks, those deficient In glucose-6-phosphate dehydrogenase had a higher (P<.005) concentra tion of Pb m the blood after correction for anemia (32.9 + 9.7) than the nondeficient (25,7 - 83), and a higher concentration in the red cells (473 z 14.7 as compared to 353 z 15*8 P< ,001); the enzyme effect was independent of geographic location, / YO 2 2784. MARKOWITZ, SAULS,, CHARLES J, MCDONALD (Roger Williams Gen. Hosp,, 825 Chalkstone Ave., Providence, R. I. 02908, USA*), WILLIAM FETHIERE and MARVIN S. KERZNER, Occupational acroosteolvsls. ARCH DERMATOL 10G(2): 210-223. Illus. 1972.-- Occupational acroosteoiysis is an unusual disease in which affected persons have sclcrodcrnu>uM;kc lesions of the skin, conditions similar to Raynaud's phenomenon, and asymptomatic, bony defects of the extremities. Evidently, the disease is confined solelv to workers in the plastics industry, s^ciftcallv those oniurcd in the productum of polyvinyl chloride ftvm vinyl chloride. The mciiience of thf disease is unknown but is thouyjit to occur in 3'l' or less of workers. 2785. JOSE, FRANCISCO R. (Dep, Phvsiol. Hvg. Nutr., Umv. * Philipp., Manila, PhlUpp.) A study of lead hazard in some lead orccess- ^ ing industries. ACTA MED PHILIPP 6;2): 46-54. 1972.--Twr bat* lyj tery plants, 2 paj>t e.^U^Lji-titnu ar.i 1 ctn.ernv mar.uiacrjn..; Icid _ c\.U -.*t re s;uau ti- L .t l.c xi * i - i`* Methods of evaluation u'eu w^re levels cf Pu ui r, ir.d Jr:r._r\ Pb, stippled red cell count and clinical manifestations su^cstive of Pb intoxication among employees m tne establishments. Levels o; Pb in air, Pb concentration ir. the urine and stippled red cell count were higher in the lead oxide and battery plants tnan in those encaged in paint manufacturing. Clinical manifestations suggestive of Pb poisoning were also more frequent, Good correlation was observed between the laboratory fmamgs and the clinical manifestations indica tive of ould Pb poisoning. 2794. LAUWERYS.R., R. DELBHOECK and M.D. YENS. (Unite Toxicol. Pathol. Travail, Catholic Umv, Louvain, Avc. Chape lie-aux Champs 4, 1200 Brussels, Belg.) Automated analysis of delta-amuiolaevulinic acid In urine. CLIN CHIM ACTA 40(2): 443-447. illus. 1972.--The addition of an Internal standard of t -aminolevulinic acid to the urine allows the colorimetric determination of this metabolite without the need of a preliminary chromatographic separation. The speed and accuracy make the procedure suitable tor the periodic control of workers exposed to Pb. 2789. MKSIC, J, and S, HUKOVIC, (Inst. Farmakol. Tlkslkol., Med. Fak., Sarajevo, Yugosl.) Uzroci nastajanja kromcnog opstrukttvnog bronhitisa u radrnka cme metalurgije. (Causes of chronic obstruc tive bronchitis in ferrous metallurgy workersTT ARK H1G RADA T6KSKOL 22(1): S-32, Illus. l&71[reed. 1972], (Engl, summ,]--An analysis was performed on 400 people working and living under differ ent conditions of exposure to air pollution, Respiratory symptoms were questioned and the ventilation function of the lungs, O- and CO2 content of arterial blood, presence of allergic phenomena, data on smoking habits and the consequences in pulmonary and cardiovascular systems were studied. The 8 metal tons that constituted the dust were Investigated. Experiments were also performed cn frogs (Rana runbunda).--J, F, L. 2790. FROLOVA, A. D. (On the methods of studying biotransformatlonof poisons tn organisms.1 PRAC LEK 24/2/31: 61-nr, ia?s. [Czech, and Engl, summ.J--The mechanism of the toxic effect of industrial poisons was discussed. The lack of methods for Identifica tion of chemical substances and products of their transformation u. biologic material, made these studies rattier difficult. Simple methodic approach affording Indirect assessment of the fate of foreign subsLincc* ui the organism had not yet lost its importance. The effectiveness of proposed simple procedures for studies of the fate of poisons was demonstrated with 3 representatives from the senes of fluorated compounds.--J. A. L. 2791. nSntOVA-BFRGEROVA, VERA (Reprints: Vera EiserovaBergerova Thomas, 145 S.E, 25th Road, Miami, Fla, 33129, USA.) and J, LUDVK CETTL. Elektricky model ,.ro vstrcbavam metabolis- mus a vylucovinl btnzenu u cloveka. (Electric model for the absorption metabolism and excretion of benreae In man.) PRAC LEK 24(2/3): 56-60. Uijs, 1972, (Russ, and Erl'"!, summ,j--The values for the resistance and canheites in the electri-al analogue were derived fcv nna,,.'gv tw physiological laciors for a 70 inlo man tblooo flew in ossue, iunc icniu ttiiui, tissue volume and tissue capacity to absorb benzene). The partition coefficients for benzene between tissue ana air and the metabolic coefficient were other limiting factors. 7Tie model was elaborated for a 3-compartment system and solved or. an analogue comixiter (MEDA 40 T). The calculated rates of uptake and excretion of benzene t).rough the lung were compared with experimental values. It was possible to predict the levels of toxic compounds m individual tissue compartments, and the velocity of their unt.lc- -md excrebon. OLI 4953 -J.A.L. So -v .-t-c s . o.N I 4327-4236 D [Voi.2 No. 5) 316 transplacental carrinngcWM* and cervical ,id* u'H .u. tmmu i by slUbcstrot are dwcusNed RES is rrjHiriiitlv linked m t .m< er nU the vagina in young women nhnsi' mother* nk RES dui mg itn^iuncv some 15 to 20 yr ago. Chiortruieri hydrocarbon heavy mnai. ,md antibiotic residues: the hind ,WUi\v> miQ\r. nnnn-, and new policy Oh Animal toxicity studies of contraceptives, csirngen* and progestii- geni arc mentioned.--P. L W. 4227. COMMITTEE OF GOVERNMENT OPERATIONS. SUOCOM- - MITTEE ON INTERGOVERNMENTAL RELATIONS HEARINGS Rrgiio. lation of diethvlstilbestrnl: Its use .in a (true lor human* and in animal * feeds: 0. U S COn6r HOUSE 92ND. 1ST SESS. DEC 13. 1971 112* 352.--Hearings evaluated cammigcmctiv of diothvlMilbcMroi IDES', tow level environmental carcinogen*. fund additive*. antibiotic drug*, meat and poultry DCS residues,--P L. W. ^ 4228. COMMITTEE ON GOVERNMENT OPERATIONS SUDCOM- p MITTEE ON INTERGOVERNMENTAL RELATIONS. HEARING. The y Safety and effectiveness of ne\\ drugs' Marltei unhdi.mal nt drug* * containing cvclamatcs ll S CONGO HOU&fc 92ND, 1ST sfess. MAY S7l971. i-99.--Hearings were held lor evaluation of ihe vicu* <i the various organizations interested in evcl.imair eniii.timitg drug* and ` food additives.--P. L. W 4229. ALEXANDER. W. G Welding hazards PROC MINK MED q OFF ASSOC SAFR 49(406): 9tM00. 1970.--A cam* with dermami* |^| of both arms and eyelids due to prolonged intimate exposure to the I'V 0 and IR rays of the electric welding arc prompuxl siuciv ot welding B hazards In the mines in South Airira European welder* who have -- bad long exposure to IR and UV ravs develop sensmvine* in such an * extent that, if they wish to continue working th(*y have to work twhind a copper screen or apron. Skin carcinomata are also n*u uncommon. A Bantu's skin pigmentation protects him <mly from the lighi-ruy*. but not the heat-rays after years of exposure. Exposure to IR and UV rays Initially decreases sweat secretnm then causes small blisters and desquamation. If exposure is great 2nd degree burns ean is* caused with big blisters--this is equivalent t< sunburn and solar dermatitis. The UV rays of electric welding cause retinal damage while ihc tft rays damage the lens and are a direct cause or ruiaract. These rtfect* arc cumulative. In all types of welding there is a d;tngcr of exposure to fumes in badly ventilated areas. Nitrous fumes. CO2* acetylene .md impurities as well as silica and asbestos (from covered rortst can accumulate in a welder's hood If it is not adequately venblaied, When welding or cutting is done un galvanized material m badly verm lull'd areas. Zn fumes are inhaled that cause headache, nausea, thirst, pains in the limbs and a reeling of exhaustion. No longterm poisoning occurs and the temporary efforts art* never serious. Those symptoms alio occur with exposure to fumes of copper, magnesium, aluminium, antimony, cadmium, manganese, nickel, selenium, silver and Un. Exhaust ventilation will prevent inhalation. To prevent the etiens of beat rays la welding and allied occupations, protective clothing should be provided. Welding bays should be constructed and painted pink to absorb the heat rays best. Welding operations can and do cause per* assent disability over longer and shorter periods depending on the degree of ensure.--P. L. W, 4230. LOSKANT. H. Industrial health service today. 2ENTRALBL 0 ARBEtTSMED 22(61: 22B-23L 1972.--The function of the industrial physician is no longer limited to maintaining healthful conditions and preventing accidents and to recognizing physical and psychic factors that might Impair the health of workers. Industrial medicine reaches out today to the physical and mental health of workers in maintaining optimal relations between work performance and the worker s physical and psychic capacity to perform the work. This brings the industrial physician into the area of work rhythm, work pauses and the evaluation of difficult conditions at work.--P. H V I. 4231. TAYLOR. W. The weavers of Dundee. TRANS SOC OCCUR Q MED 22(21: 37-43. 1972--A rctniMpcruvc *iuriv o| the Dundee irmalc ^ weavers using 493 ears determined the progressive deterioration with Ums up to 50 yr exposure to loom noise, of the purr-lone air eontlur- tton threshold audiogram. Comparison of the hearing levels with age- matched. non-noise exposed controls showed that the ucavrr* suffered considerable tosses, especially in the irequenry range >if 2kH and above. Median estimated threshold shifts of 50 dB were found at 2. 3. and 4 kH after 40-45 yr of loom noise exposure. Two tesi populations each of 20 subjects with normal hearing (age range 17-351, 1 group in Dundee and the 2nd in Southampton achieved 50', phoneme scores at 1$ dBfAl peak level at the ear for fare 10 fare conversation against the BOdB(A) ma<kmc noise Speech nudon:etri conducted n *h>> weaver and Civr.t."'*l p^t-uEttu..-.* M .,v. 'u j'.< . vv* n * ,,r:: impairment eould not understand sitfrch at on* level Jhe n.im haMi- cap concerned difficulties exponent ed m communication Am.mgvt the weavers there *as a striking difference ir* the ownership >u tele phones <8G 1 compared with 58'. in the control group, reflecting dis satisfaction with the instrument as a means of communication. Despite the M(gi proportion of weavers who considered their hearing worse than normal f81' compared with the controls 5', 1 only 8 of this weaver population of 96. i.e. 9'. had a hearing aid and only 5', used an aid regularly.--P. L. W. 4232 MC LINTOCK. .1 S Principle* of the com rot nf occupational iliM-aw. TRANS SOC OCCUR MKU 2i<3>: 70-82 1072 .-The 1)1 Uld q major step in the control of any occupational health problem it to try y to alter the environment and (pus eliminate the problem. If, however, y it is not possible to be sure that the problem is completely eliminated, A then in addition to environmental measurement it is essential to moni tor regularly the health of the exposed population. The purposes of periodic X-ray examinations are 2-fold: to identify the earliest tugc of change and to try to control the workman's further exposure, to measure the efficacy of preventive measures and thus to demonmritc those places where more effort is required. The chest radio graph Is a useful tool In certain of the pneumoconioses. X-rays of kmc probably have a useful role in workers In compressed air and possibly in mcri operating certain vibrating tools. The value of radiography in measuring bony changes in the spine is quite uncer tain. and the X-ray dosage involved raises ethical problems in any system of periodic spinal X-rays. The principles involved in using radiology .is u rontrol measure arc the: validity of the X-ray appear ances. periodicity of examination, representative nature of the popula tion examined, standard and eonsieteney of the quality of films, inter pretation of the radiographs, use of the results. A sophisticated staUNur;il approach s necessary If the epidemiological results are to be used successfully 10 improve environmental conditions.--P. L. W. 4233. 4ACODSEN. M. Evidence of dose-response relation in pneumoconiosis: D. TUANS SOC OCCUP MED 22(3): 88-94. 1972.-- O Recent interim reports of 3 long-term epidemiological studies of X dose-response relationships in pneumoconioses art discussed with special reference in the problems of methodology and inference In herent in the abandonment of the clinical or laboratory setting. All reports nxiclude with quantitative statements relating the dose of * inhaled dual to the risk of developing radiologically defined pneumo coniosis. They are concerned with silicosis among European gold miners in South Africa (Beadle. 19711. and coalworkers' pneumoconio sis m ihc Ruhr coalfield (Reisner. 1971) and in Great Britain (Jacob sen. ci. al. i. The 3 studies are compared epidemiologicaliy under the headings of subjects, stimulus and response.--P. L. W. 4234. 5CHWETZ. F. Are hearing tests necessary during continued work in a noisy environment? MQNATSS^HR OHRENHEILKD q LARYNGORHINOL 106(7 8): 344-352 1972.--According to ,omt y authors, occupational hearing defects due to excessive noise do not develop after the 12th or 1 Sth yr of work. From that time on, the audiiorv thresholds in the upper frequency range are expected to shift for rrnsws o( the person's age only, tf this reduction in the heanng capacity were general, most of the time- and money-consuming audio- metric tests, which the Individual person exposed to excessive noise at work has to undergo till his retirement, would not be necessary Observations extending over several years have shown that the hearing loss may br aggravated even a long time after a person has retired from work involving excessive noise. Both old and young workers may be affected by this phenomenon, at well aa workers whose bearing was only slightly impaired before or whose hearing was characterised by a pronounced "resistance to noise." The possible causes for such a "late" reduction in the hearing capacity art discussed. Specific hearing tests are suit required for a final clariflcaucn. In the interest of the persons concerned, such a reduction in the hearing capacity must not be overlooked. Regular check-ups are necessary during the ume the,person is exposed to excessive noise at work.--C. M. M. 4235. DANJOU. F. Collective alimentary lead poisoning aboard a lanktr REV CORPS SANTE ARMEES 13(3); 255-26371*72.- p Pipe, mldorcd wttli a hipti Pb mixture, placed in the bottom of a ^ vine vat <M board on board an oil tanker, caueed aever* Pb potaonlnc q in 7 members n! the crew and mild or asymptomatic intoxication in 13 others of a crew of 33 on a voyage from France to the Persian Cuff via Cape Town, South Africa. Physicians who boarded the vessel in the Gulf failed to diagnose the intoxication. This was discovered in Cape Town m the rviurn trip, after 2 patients were hospitalised there and samples of (he wine analyzed.--P. H. V. L J 4236 CHRISTOPHERS. A. J, Occupational aspects OfRavnaud's^ disease; A critical historical survey MEDJAUST &(13): 730-733. O 1972.--The literature is reviewed beginning with the lit descriptions T of occupational Raynaud's disease (bone resorption and disturbed blood supply of the extremities in the 2nd decade of (his century). At the beginning of the 4th decade, the importance of vibration in the etiology of the disease was indicated. This idea solidified during this decade and the next to the extent that the disease is now called "vibration disease." or "vibrxtmn-imtueed white fingers." instead of "Raynaud's durnsr " Vihruton *,>. acrcpted erroneously as an r'tin(ri|>iexl factor, and the perpetuation ot this error has confounded investigations into the etiology of the disease. Certain potyvmyll chemically-induced occupational manifestations of Raynaud's disease were recently described as a new disease named "occupational acroosicotysis" and spurious etiological factors were postulated for it. Vibration is not a necessary predisposing (actor, as attacks take plaee in persons who have not been exposed to it. The occupational factor that stands out as being the most likely predisposing cause is repeated chilling of the body and or of the hands.--P. L. W. OLI 4954 3/3 |May, 1973) C* 4820-4032 tow-ird* nonnnltzMiou. Hu* hilrnntrml comlm-lion was iffMoimI |u uoinr c.tRPS, KuciUgcnulouiCul studies revealed cnLinienionl of the left ven tricle or the I and II decree m 25f..' of the cases. There was an increase of the eholcfltcrol level and ()-h|x>prilcin (rartlon, Thesr ctuim'es de pend directly uj*m the duration of the diMiii! u,--C, S, 4820. ELETSKII, Yu, K. (Oep, CytoL Histol., N. I. Firo^ov 2nd 2 Mosc. Med. Inst,, Moscow, USSR.) Vliyame ostroi aikocol'noi intoksi* katsii na ckislitei'noe losforilirovarue v pechem krya. [Effect of acute zlcohoLc hitoncatlon on oxidative phosphorylation in iheliver of raTs,} >ARMA)iOL TOKSiKOL 35(2): 1S8-199. 19 ;2. | Kngl. summ.|--Tests conducted on rata demonstrated that introduction of alcohol in a dose of 11 ml/kg causes a fall of the P/O factor in 15 min. Changes reach their peak by the end of the 1st 24 hr with normalization setting in to wards the end of the 9th day.*"A. F. K. 4821. BLOCK, ROBERT A, (Dep. ObsteL, Gynecol., Thomas JeN 2 ferson Uftiv. Heap,, 1025 Walnut St** Philadelphia, Pa. 19107, USA.) Pregnancy in portal cirrhosis: A case report. J REPROD MED 8(3): 143-145. 1972.--Liver function studies were made during and after pregnancy in a 39-yc-old alcoholic with portal cirrhosis. After S mo. these studies were re-evaluated as to the effect of exogenous ethynyl estradiol. The abnormalities of the Liver function were a result of the continued alcoholic intake, and were not affected by either the preg nancy or the exogenous estradiol.--J, j. B. 4822. DENNISON, C. (Natal Auric. Res. Inst., Pietermaritzburg, y S. Afr.), It. H. STEAD and G- V, QU1CKE. A non-hnoma!iglutin:iting 2 toxic factor from the jack bean (CafinvnOa ensiformis), AUUUP'OtNT- Al 3(2): 27-20, Ulus. 19/l[rccd7 1972], [Alricaans and Fr. summ.)-A method was developed lor the preparation of a toxic, hemagglutmating crude extract of jack beans, which is devoid of trypsin inhibiting activ ity. The toxic and hemagglutmating activities were subsequently sepa rated by selective adsorption of the hemagglutinin (concanavalin A) onto Sefdiadex G-1QQ, demonstrating that these activities are due to 2 dis tinct molecular entities. The toxin was further purified by chromatog raphy on Sephadex G-200.--E. 5. 4823. MAGOG, L. and W. H, BUTLER. (Med. Res. Counc. Toxicol, M Unit, Med. Res. Counc. Lab,, Woodmansterne Road, Carshalton. Surrey, p Engl., tlK.) Cumulative effects of methvlmercury dicyandiamide given orally to ratal FOOD COSMET TOXICOL lb(4): 513-317. Ulus. iu72. --the changes In Hg levels in the tissues and pathological changes in the brains and kidneys of rats given daily oral doses of methylmercury dicyandiamide are described.--J. E. F, 4824. JARQ6S, WERNER (Med. Akad. Carl. Gustav Carus. Abt. Z Klin. Lab., Fetscherst. 74 , 8019 Dresden, East Cor.), MAKKOLF HANEFELD, KLAUS ULRICH SCHENTKE. ALBRECHT TKUEDSDACH, BORST STOETZNER, WOLFGANG LEONIIARDT, VINCENT HERRMANN and RUDOLF FUCHS. Veraenderungen von metabouschen Parametern. insbesondtre dee Fettstoffwechsels bet chronischen Alkoholikern unter klinischer Alkoholkarenz, [Chances of metabolic rwrameters, especial ly fat metabolism in chronic alcoholics under temperance.I Z GESAMTE INN MED GREN^GEB 27(V); ili-316. 1S72. [Engl, and Russ, tumai.]--In 41 otherwise healthy chrome alcoholics immediately after admission into s sanatorium for alcoholics as well as after a 7 to 14 days' temperance apart from numerous examinations of the blood. Menghuii-punctures of the liver were carried out. Within an average of 10 days the latty change of the liver decreased. The flowing off of the triglycerides seems to be carried out exponentially. In uncompli cated alcoholic fatty livers a half-value period of the triglycerides of the liver of about 4 days is calculated. During the period of temperance the free fatty acids, the phospholipids, cholesterol and bile acids signifticantly decreased ui the serum. At the same time an ascertained de crease of the uric acid, of bihrtfcm, the glutamic oxaloacetic trans aminase, of total protein and of the r-protcin* could be proved, whereas the albumins increased. Ui lipid electrophoresis most frequently there was an increase of the a -lipoproteins in the 1st examination, which rapidly receded. There was a highly significant connection between daily alcohol dose and fatting Level of the free fatty acids,--p. L. W. 4825. TATA. J. R. (Natl. Inst. Med. Res., Mill Hill, London. Engl.. UK.), MARY JO HAMILTON and D. SHIELDS. Effect* of tT-amumun U in vivo on RNA polymerase and nuclear RNA svnthesis7 NAT NLW Z BIOL 238(84): U1-JG4, Ulus. l&W.--The (umtal toxin -amamtin given in vivo selectively inhibits for 10-60 min a nucleoplusmic type of RNA polymerase in rat liver but the synthesis in vivo of all species of nuclear RNA remains blocked for several hours.--J. F. L. 4826- BROOKS. ROBERT n, !r, and TA'.fE-S A. Vlf?". ;r- i\ "-..-iv* V acol., Walter Ructl An.u ln*t. Rea.. Wnwr Peed Arm*. Mod. i_m*,, 2_ Washington. D. C, 20012, USA.) Toxiculoncal studies ot uc-c vgrvMi. in mice, docs and monkevs. AM DLEJ HSiTi: 230-231, 1072.--Venom of Apis mclUIcra was itpeeted. either i.v. or s.c., into experimental anunalb. I.V, injections caused a precipitous decrease in blood pres sure within 35 see in both dogs and monkeys, ft also decreased heart rate and depressed respiration. Dosages of 5 mg/kg in dogs, or 2.5 tng/kg to monkeys, i.v., caused death from cardiovascular failure. Ulmltir ronpunsrs were noted siller s.c. injections, but median lethal dosages were higher: 200 rng/kg in dogs and 50 m^kg In monkeys. The former is equivalent to about 2000 ben stings. Smaller cbsngoi were fatal tt> mlcr. Uther physiological reactions are noted. --J. D, Hitchcock, 4827. KOUUUYA, N, S,, L. E. CEDYMIN, F. R. CHERNYAKHOVSKII and O, P. ARKHIPOVA. (Cent. Res. Inst. Tu&erc., G Minist. Health USSR, Moscow, USSR.) Izucheme promtsaemosti gisto- T gematicheskikh bar'erov pn razlichnykh rezhimakh giperbancheskoi oksigenatsu v ckspcnmentc. [Permeability of histo-hnematic barriers In different regimes of cxperimcnLil hyperbaric oxygcnation.l EKSP KJIIR ANESThZlOL 17(2); 31 -33. Ulus. 19727] Engl, summ.j --Ex perimentally, 70 guinea pigs were subjected to 100% O2 in therapeutic (1-2.2 up to 3 ata) and toxic (4-5 ata) regimes of hyperbaric oxygena tion for hr. Histology and radioactive indication (with strtptomy* cin-$35 m 20,000 U/kg and with 14.2 pCi activity m 1 ml) were used to assess various permeability levels in the htsto-hematic barriers of the lungs, liver, kidneys, spleen, myocardium and brain. Toxic regimes were accompanied by a universal increase of vascular wails permeabil ity, conditioned by structural Lesions of the histo-hematic barriers. With therapeutic regimes, vascular permeability rose only in the spleen, liver and kidneys, i.c,, in the organs with an increasing functional ac tivity under hyperbaric oxygenation, and was not accompanied by histostructural changes of the main elements of the histo-hematic barrier. --J. L. S. N "OO 4828. CONDEH, D. W,, P. C. OLOFFS and Y. S. SZETO. (PestoL Cent., Dcp, Biol. Sci., Simon Fraser Univ., Burnaby 2, Q. C., Can.) GLC serxiration of hcntachlor epoxide oxychlordane, o- and y-chlorriane. DULL ENVlItoS'CWTA/d TOXICOL l(l): M-JSTlt'l.--ULC [gas----liquid chromatography] columns were used to Identity and quantitate organochioride pesticide residues. Such a* 2% OV 1, 2% SC 30 plus 6% OF 1, or 3% OV 1 plus OV 210. They did not satisfactorily sep arate the compounds of o-chlordane, y-chlordane otychlordane and beptachlorepoaide. Gas chromatograph Micro Tck MT 330 with N1-S3 electron cepture detector method was employed to this experiment. ~J. P. K. 4829. WALTSCHEWA, W. (Forschungsinst. Arbeitsschutx. Beruf- skr,, Blvd. Petko Napctov 34. Sofia, Bulg.), M. SLATEWA and I. M M1CHA1LOW, llodcnveraenderungcn bet weissen Ritien durch chron- ische Verabrcichuni: von Nickclsultat. (Testicular changes due to tong- term administration of nickel sulfate in rats,I EXF PAfllSL ) i(3/4J: 116-120. Ulus. I37i. (Cnel- summ.|---Followinq lonR-term nickel-sulfate intoxication in rats, severe lesions in the germ ceils particularly in spermiogeneais could be demonstrated. Very few chang es were observed in the livers and kidneys. Nickel sulfate had a se lective noxious effect on testicular pnrtnchyma.--A. D. M. 4830. BASALAEV, A. V.. A, N. VAZIN aad A. G. KOCHETKOV. (S. M. Kirov Gork. Med. Inst., Gorki, USSR.) K patogenexu tamenenii, G voxnikayuslichikh on dlitel'nom vozdeistvii vlniikhlorida. (Pathogenesis Z of changes developing due to long-term exposure to the effect of vinylchloride.I GIG TR PROF ZAOOL 1613); i-37.~iiius. 19TC~lnvl` summ.)--Rabbits and rats which inhaled vinylehioride lumen ui a max imal permissible concentration 10.03-0.04 mg/1), underwent a 6-mo. long all-round examination by physiological, biochemical, histomorphologieal and roentgenodensitometnc methods. Changes in the bio electric activity of the hypothalamus, hypsradrenalinemla and function al troubles of ths cardiovascular system were disclosed. Development of resorptlve manifestations in the bone tiseue wae brought out mor phologically and osteoporosis-roentgenologicaUy. An inference is drawn as to a key importance of hypothalamic dysfunction in the patho genesis of the disease, this dysfunetion giving rise to neurohumoral and neurovascular troubles leading to the development of dystrophic pro cesses in the bone tissue.--P. L, W. ' 4831. COOPER, PHILIP and STEPHEN H. TOLINS. (Dep. Surg., Bronx Veterans Admin. Hosp., Bronx, N. Y. 104G3, USA.) Relationship u between smoking history and complications immediately loliowing 3ur- w gory (or duodenal ulcer? MT SINAI J MED 33(3): 2S7-202. 1072.-- No evidence is given of an association between smoking and compbcatioiis, ntr between smoking and operative mortality, nor between emitt ing and days to discharge. The most obvious trend is probably predict able, namely, patients over SO have more complications and a higher mortabty rate than those under SO. In spile ol the relatively large number of jxiticnts included in this report the smoking habits, the age distribution, and disease rate in the population studied are quite likely to differ from the general population. Some inconsistencies we re found between smoking histones Liken on the same pnlient at different times. Tl*: t rt.v: e it r r--tilt.-r) from the quahiv and accuracy of the lnurp.a- tion uvon ta me examiner by the fntier.t. Few, tf any, generalities snouM uo drawn from this research. Results apply only to immediate postoperative findings and do not apply to long-range eilects of smttting upon the patient after surgery far duodenal ulcer diseaee.--E. M. D. 4833. LISITSA, F. M. and L. A. MOTRCNA. (Fat. Postgrad, Med.. Riga Med, fnst.. Riga. USSR.) O kiinicheakikh osobennostyakh alkogoi'- 2 nykh polinevntov. ICIimcal traits of alcoholic polyneuritis.I ZH NEV- OLI 4955 WSJ NANACf"rNI INf.lORGlA/ ABSTRACT 0*4 ) loris 12 (91. 1*72 7*1* AAIVAWANSA N THE sevens CANAL POLLUTION JM COLOMBO* WATERWAY*/ CEYLON PAGE 212-2)7 beamuoa ncx. stn res spec nun f, 1*71 (REC0. 1*TM 7*17 VtllCR S MOODY J PAVlCN M A STUDY OA- TmE ffRECTS DM MATE* tHCMlSIRY BY tfPLUtNTt Of THE HQLtDAY INN SCVACr OUtPALl/ TOBACCO |AY BERMUDA PACE IM-'ITI fSYCHOTHER PSYCHOSDN 21 ll-AU 1*72 7*1# T*l* 7*20 CHfRTDR L BOURGIGNON 0 VEIL C PSYCHOLOGICAL EDUCATION OP PHYSICIANS IN INDUSTRIAL MEDICINE/ WHAN PACE US-IAB OELASNEAlf * NYSTCRICAL CONDUCT \H MALI INOUSTRUL PERSONNEL/ PRJMAN TRANQUILI2CR page iA*-m GELLY P PSYCHO THERAPY IN THE MILITARY ENVIRONMENT/ RINAN AG0RES1IV1TY PACE ifj-isi AGING HJR QEY ******t*(S*I**1*72(RtCD, 1**7*7** T*2I LIMN H w LINN b s gaeenwalo s a the alcoholic patient in the nursing home/ tJRRtVSIS BRAIN DISEASE PAGE 271*277 VA 4 SCI IS 111. 1*72 T*U m> 7*24 T*tS 7*24 , T*2T f*2# 7*2* 7*19 7*11 ELDER 4 m JR ft|Nf au ft JR SIMPSON t W INPLUENCE OP SOILS ON CONTAMINATION OP A WATERSHED BY SEPTIC POLLUTANTS/ ABSTRACT DOMESTIC WASTES PECIS COLIPOAN COIMTS PAGE IDO RCNEAU B JR PETTRV D E THE MOVEMENT OP SEPTIC TANA (PPLUCMT |N SELECTED COASTAL PLAIN SOILS OP VIRGINIA/ ABSTRACT USA CXIPORM MCTIRIA PAGE 102 AMOCRSON G ( THE EPPKTS OP OIL ON THE GILL PfLTVATIQN RATE OP NYA-ARlNARfA/ ABSTRACT ftOQIOS* PAGE ID* GREGG B C BENPICLO I P TOXICITY OP ||NC SULPATE to ISOMVtMIA-SAOLPRt |PnEN(AOPTRA ISONVCHI IOAE PROM 2 STREAMS/ ABSTIUCt NYMPHS WATER CHEMISTRY SKI *Ttll020 PAGE no HASTINGSw S AtNBROUGH T 0 LLEWELLYN G C O'REAR C E RIA P N THE EPPECT OP 01 METHYL POPMAMIOC ON MRIQMES-UNGUKULATUS/ ABSTRACT NtLO CARCINOGEN LlVft DISORDER *122 PAGE in LEVY G P AM R L SPENCER I S POWELL C ASHWORTm R WQOOROPP L S PENNEMA R AM INTEGRATED STUOV QP TnE NORTHWEST RIVER ANO ITS WATERSHED/ ABSTRACT PLORA PAUNA PORfSI TYRfS PHOSPHATfS CHLORIDE NITRATES ALKALINITY mARONESS PESTICIDE RtSIDUCS GEOLOGY 1424)447 lAftftTOOA l*f*7S PAG! 112 LYNCH M P WEBB R L THE USE Of SPRUM CONSTITUENTS Of TMf BLUE CRAB CALLINCCTCS-SAPIDUS AS INBICATORS OP PHYSIOLOGICAL stress/ ABSTRACT l|0 TIDE TheRhal ST*ESS CHLORIDE ION PROTEIN GLUCOSE PAGE II) MORGAN | L SPAMS R E GARVIN 4 A CAIRNS 4 J* 2* Aft AND H N)U* MEDIAN LETHAL CONCENTPATION POR BlUlGlLL LEPONIS*MAC#OCf*US IIPCSED TO HtXACHlOR0HENf / ABSTRACT a70)04 PAGE 114 PYLES A f RfA ( W LLEWELLYN G C D`M* C ? T**t iPffCT OP fpPOS'RE Of CALCIUM CrCLAMTE CN MfP IDNES-UNGUlCUL AT'JS/ ABSTRACT URINARY BLAODf* HONEY LIVER *RC CARCINOSEVIC ACTIVITY *11*0*0 PACE IIS SCHfflf R A LLEWELLYN G C Q*Af* C E (4011 T THE OCCURRENCE Of APLA TOXIN IN SAMPLES Of PEANUTS PRO" VIRGINIA/ ABSTRACT USA PAGE ll* 1 7*72 T*J 7*14 TORRES J J MANCUN C P EfffCT OP N|tH QlVCtM LfVHS ON NARINE (NYC*7C|AAT|S/ ABSTRACT NAAlPtANfUAHUClAC AURELIA-AURttKA *77*24*7 PAGE 111 CLINE 1 A COX C III WIOH PURITY OXYGEN AERATION Of PROCESS WASTE WATER/ ABSTRACT pace is; MALL J JR APPLICATION Of AERO SPACE WASTE ACCLAMATION TECHNOLOGY TO OONESTIC WATER RE CYCLING ANQ SOLID REDUCTION; ABSTRACT PAGE 111 +1) PEIS (PCD EU* IIOCNEN SOC) LETT I* U>. 1*72 N mj OtSNES S P|HL A TREATMENT OP A|R(N ANO R(C|N WITH BETA NfRCAPTO ETHANOL OPPOSITE CPPECTS OH THEIR TOXICITY IN NICE ANO TmEIR ABILITY 70 INHIBIT PROTEIN SYNTHESIS IN A CEU-PRfC SYSTEM/ ABRUJ-PMCATOAIUi MCtNUS-COMNtMlS PACE *1-70 CURR SCI (BANGALORE) At 1*1. 1*72 44***4****4**4*****4*a****a*4****4*a***********' TOM RAO A T ACHARJVO L N (* PAR NfNO SIOIROSIS IN A NUSCQVY OOCR CAIRINA-MOSChATA/ MOTE PUNGAL PEED TOXINS LIVER BltMIY PACE >42 ***********+****#****************> N ENGL i NED 2ft? 1221. t*?2 DOG PAGE U14-UIB ** *#*****a#*aa**aa***a****M*Y*aa*aaaa*#aa*a***** V S POA SfAV ACS NOTE HE 140. l*Tl IREC0 1*72) aa**a*a*aaa*a*aaaaaaaa**a4a*aaa**a**a4*aaa*aa*aaa4*aa**a*a*a T*lft LVONARQ A ( HERRINGTON L P NOISE ABATEMENT IN A P(NE PLANTATION/ SOUND ABSORPTION PAGE 1-4 ***w********a**M*****t>***fev***M**4****# **#******** Y|T tie *1 12*1. 1*72 IRECO. 1*7)) 7*1* HEARD T W ADDITIVES IN PfCD ANO THE EUROPEAN ECONOMIC CONNWlTV/ HUMAN PAGE 49WB4 CAL IP AIR GUAL 0474 4 111, 1*12 7*40 CAL IP AIR RESOUR BOARD CALI PORN(A AIR DUALITY Ok74 JANUARY THROUGH MARCH 1*72/ USA QltOANTS CARBON MON QltOf SULPUR 0| QMOE N1TB1C OXIDE NITROGEN 01 OXIOE HYDRO CARIONS LEAD PARTICULATE NATTER *1010241* 744*0*1 741**21 *10102440 -4)00*0 PAGE 1*4* PCD RRQC 12 |1 PART 11. i*T1 7*41 . ?*4( 7*41 r**4 7*41 RONIJN A M GUGQCNHEI* R CHARACTER HAT ION ANO NQOE OP ACTION OP A GOITROGCN PRESENT IN SOYBEANS/ ABSTRACT RAT OLtGO P<RT!OC SUGAR lOOtNt INHIBITION PAGE 21* ftERT N H SNOEYENftOS G H MAPAR4CHISI R A ANDERSON 0 L NAWAR W W tOMClTY OP SOME SATURATED ANQ UNSATUAA7E0 DIETARY HYDRO CARR94S/ ABSTRACT HUMAN MOUSE BEEP PAT |RR40|AT(OH PAGE 22) TfRHAiR C 4 BRAltyitf y j ASTIlL 0 PASserr o w NO4GAR7I0GC R t roudaiuih r l wolp l mono rririARY butyl hvo*o Guinome t its sapety evaluation in thfati/ ABSTRACT RAT MOUSE CUl*E4-PlG DOG POOD GRADE ANTI QxIOanT |741)0 RAGE 27) PPUOCRCR P PRAHCIS A 4 DOHERTY 0 G THE E'PfCr OP PHTMUATf ESTERS On THE HEART RATE OP The GOIDPISh/ ABSTRACT RENITLBUTTL RHTHALATE 01 OCTYL PHThALATE ATROflNl C4RDI0 V4SC-0RUG *117*40 *ftS*#r PAGE 224 1EB4LL0S 6 4 m>NOl C RASULT0 J BOSCO C SAlIMAS-JfftALLOS M E OLI 4956 OQi [October, I9/J] mu v in i Inliliv,i .* all Pl i ii. ti'.ihi'ii. Ai i***- en.i phalopnh, in .* overshadow Us i i nm. Inn chionic oxpo..ure In )'b m, I'I'hIuiv cLjii-'i " in ponpheia) ihti r jbers ih.it result in aher'd ` **n.lu.*tit*n ch.ir.ir k i isiu .-. In tins Mudv 24 Host mi, liusi If', < "IA, child ren '#o*i known plumbism were found to have reduced no "an nnnor iicrvi* conduction velocities* as compared with normal children. Jhi^ finding ir.av provide a valuable test for discovering minimal peripheral ncuro* toxic effects of chronic exposure to Pb ingestion. 9477. THOMSON, MAURICE L. (TUC Centen, Inst. Occup. Health, g Lond. Srh. H\g4 and Trop, Med., Keppel St. Gower StM London WC1K 2 'HIT, Lnul.f l?K*) and DEMLTKt PAVIA, Long-term tobaern smoking and mucociliary clearance; From the human lung in health and res piratory impairment. A.UCH ENVIRON HEALTH 2G(2); 80-89, Ulus. 1973.--The rate of mucociliary clearance was estimated from the re moval of inhaled radioactive particles in 79 elderly subjects of whom 80 had health.* lungs and 29 had respiratory impairment (lint was ob structive in 13 and restrictive in 10. The 29 impaired subjects had on the average a faster clearance than the normal group, a difference that almost approached significance (5V level) at 6 hr after the inhala tion of the aerosol. The obstructed subjects showed the fastest clear ance with the restricted group intermediate between these and the nor mal group. No significant difference was found between the* rates of clearance of smokers, nonsmOkcrs and ex-smokers in either healthy or diseased groups. 9478. PEKKANEN, TIMO J* and KALEVI SALMINEN. (Dcp4 Food M Hvg., Coll. Vet. Med., Helsinki, FinL) Inductive effects of mothvl mercury on the hepatir nncrosomes of mice. ACTA PJiAHMACOL 1973.--MalcNMRI mice ]3G) weighing about 17 g each were divided into groups of 12 animals* Groups 1 and 2 were treated once i.p. with methyl mercury nitrate. Group 1 received 0.3 mg Hg/kg and group 2 10 mg Hg kg in 0,5 mi water; the 3rd group, which uas kepi as control, was treated i.p, with 0.5 mi water, After 7 davs all the mice were sacrificed. The moan total liver protein was significantly decreased in group 2. The mean liver microsomal pro tein was significantly (P<0.01) increased in groups 1 (P<0,01) and 2 (P^O.02) as compared to the controls. The mean cvtochrome P-450 concentrationof the liver tnicrosomes was also significantly increased in groups l (PCQ.OQI) and 2 (P<0,01) as compared to the controls and in group 1 (P<Q.01) as compared to group 2. The mean liver micro somal NADPH-cytochrome e-reductase activity was significantly greater in group 2 (P< 0.001) and in group 1 (P<0.01) than in the con trols. The mean NADPH-cytochrome e-reductase activity of group 2 wa*. also significantly greater than the mean activity in group J (P 0.02), 9479. HARRIS. A. BASIL (Dcp. ftcurol. Surg., Univ. Wash. Sen. M Med., Seattle, Wash. 98195, USA.) Ultrastiuclure nod lustorhcimsirv pf alumina m cortex. EXP NEUROL 38(1)*. 33-0371110*71973.-* " Aiieif injection of the epileptogenic comjiouiKl alumina, iiilu the Cortex if 2 adult monkey* (macncn mulatto, jmsiUve hi>;tueheimcal reactions occur in the lesion border immediately and later in macrophages of the granuloma, blood vessels and cortex. Perivascular alumina de posit* may appear intrancuronaijy but are overiymg impend, Mod erately electron-opaque aiununa crystal#.-->015 A wide bv trfJO A long increase their densities by adhering osmiophihe serum and cell products. EfKtocytosad crystals are seen in monocytes, fibroblasts and astrocytes, but not in isHyuturphoiiuelcnr leukocytes nr neurons. Macrophage secondary Ksusome.s, cumpJux rytoscgi e.iumes and dense and light vacuoles contain crystals at all stages from 1 day U/ 5.5 yr after injection. Some crystals appunr untangled in filaments :iik1 microtubulus without definite limiting membranes. Intiaccllulai alumina is associated with mu eased cytoplasmic filaments, mulijvcxiCular bodies, ivsiunes, free rdtosomos, autophagosomes and multiple vacuoles, lnlia* ellular ttigesuve processes may sluwlv degrade crystals into soiuble compounds reflected by increased fiiamenis in astrocytes and mncrophnuuii. These rliangcs may indicate the sues of importance in the genesis uf tins type of I'Pilvpx). 9480- PELLtvG. b. tUv. b*l. Rml it, *. a ,s.>, \t,..j-a. Mi, Road, Cat skHton, Surrey En I'R.i, M.a'HARRAi I ,u.o .<t/.i\ iiARRV. D The >afeU lesiug: tm (hr.tf j.lastic... I \n .tsessm. ni 4n,w. a., Z TubDGOSMEl ItKiCOl. i i in la-v:i,'niirr.'l J|3 [j .ii.d ;; i" " suinrn.J--'i he t- \n*u\ .fpi.i.m . u..-.n.,[ if. . . , u..,,( u, inedicuie and o'a i p .lv v n,. I vMoj nlc (PV t`i ,, ,t. kniiW.. Conslllut|>.n -.a ' i d li, u -su. t nM.uv l- . )im<|.i. ,, ui.' plantation tests m r.tf.i,n n.i: .civ .mil t.n .ul ut .<>. ..n . u , ,)(U| oaimiuatiun of .......... mi. admmtsti i m< . ui... . . ,,f * j.. jilaslicb to I ats ai mu c i'V C -vunpH * t nnutimn" l n.>uj. . .1Jlt mu .. tiuns of an *l ganotui vomtKiund Wei e u.ied as )fositive . onli oIh, ',.,11^ Of the ic.'-t plasties `*xhpnn*d to-.n-itv as high as that of in. Control pJa stirs. 'J In* l*. .* < uUm < u - w.i . th. ,.),-afiv* litviiiod u -I'd :.I.'I t.-xi' I`H* * > ti i- tl, . t.-d Witli a I.'W ,,f n,, rt plastlk*. Liipl.u.Litioh 111 1 ,d.;u >.I. I opu. Ill I.IU'I [ 1..I d.i'.t. u.1* the muse sensitive of th*,* unp,m( sv -lita.i tLs<ed and tin* n .all', snowed a g-^al eon elation Aith tissue culiui c 1 In svmi. mu tt*sis >.u extracts failed io demonstr.iu tuxiviiy, even with tin |s>siti\e 1 ,ni 1 //r M J* ** ,-^J ,9X1 2 9477*94 04 t !a:.||r`i, hi view of tfn- lui'h n.-oidivitt >/ ti .j. rultuif, poMitiV.' 1. nulls sliould not neCcnnai ilv indicate Jejecnoii of ,1 plasln a material for medical use. In such a situnU.n, additional experimental evidence was icquU'cd. 9481. WLNbELLK, A. 8. Jr. (Exp. Dent. Sect., U. i>. Air Force Seh. Aerosp. Med., HiooL.s Air l*orce base, Tex. 78235. UiA.) Detei - Q minatmn of mercury in parotid fluid. J DENT KES 52(1): 19-25"! m Jllux. 1973.--Analysis of H^j in parotid fluid involves aeration-reduction or Ilg and measurement of spscirophutomutric absorption of the evolved Hg at 2.537 A. This procedure is quick, sensitive, and accur ate and does not require die extraction of the element from the sample before analysis. The s d for ihu method was 0.479 for samples of parotid fluid Containing 6-31 ng hg/ml. 9482. KACEW, SAM and RADHEY L. SlNGlfAL. (Dep. Pharmacol., llniv. Ottawa, Fac. Med., Ottawa, Ont., Can. KIN CN5.) Adaptive res- p [SHiso of hepatic carbohydrate mcta|>olism to oral udmimstration of** 2 TUtrichluro-Z ,2-bis (p-chloroplicnylf ethane in rats. bToCHEM PHARMACOL ^2(1): 47-57. IJJus. 19f3.--Thc effects of an acute dose of p,pf*lTl,l*trichloro-2(2-bis (p*chloropheuyl)cthane (p.p'-DDT) wero studied on the actlviUes of pyruvate carboxylase, phusphoenolpyruvate earboxykinase, fructose l.e-diphospliatasc and glucose 6-phosphatasc in rat liver. Administration of p.p'-DDT (60b mg/ kg, [orally]) produced 2-lu 2.5-fold stimulation of these key gluconeogenic enzyme* ill 5 hr; statistically significant increases could be detected at 1 hr. Blood glucose increased as early as 0.5 hr, attained peak values at 1 hr, and declined to reach control levels m 3-5 hr. Hepatic glycogen decreased gradually to 47% of the control values in I hr and was restored by 3 hr following treatment with this insecticide. Administration of p,p'-DDT 10 adrcnalectoiuizcd rats produced similar changes in blood glucose and hepatic glycogen, suggesting that the insecticide-induced hyperglycemia and glycogenolysis may not be mediated by a release 0/ caiechola/mnes from Die adrenals. Dose-response studies revealed that 100 mg/kg of p.p'-DDT was the minimal amount necessary to induce statistically significant increases in the activities of hepatic pyruvate carboxylase, phosphoenolpyruvatc carboxykinasc, fructose l.ii-diphusphuLise and glucose 6-phosphatasc, Maximal stimulation of tho 4 key gluconeogenic enzymes was seen generally at 5 hr when rats were treated with a 400-500 m^/kg dose of p.p'-DDT. Daily administration of muall doses of p.p'-DDT (5 or 25 mg/kg) for 45 days also resulted in significant enhancement in the activities of various hepatic gluconeogenic enzymes. Actmomycin D, cycluhexinude or ethionmc failed to affect the basal levels of either of these hepatic enzymes but effectively reduced the insecticide-induced increases in various enzyme activities. Treat ment of adrcuulucioniixud rut?* with p,p'*J)Dl' enhanced various hepatic enzymes to a degree similar to that observed m intact animals. Ad ministration of triamcinolone io p.p'-DDT-treated udrimnlcclomizcd rats did not jxateiUiate the action of ilie insecticide on any of the gluconeogenic enzymes examined. Treatment with p.p'-DDT apparently produces marked increases in the quartet <>f he>, rate-limiting gluconeogenic enzymes in hepatic iiSMie winch are not mediated through a release of corticosteroids from adrenal glands. 9483. UUDKKAU, CLAIRE U. (Dep. Anal., Health Sci. Cent., Uiuv. West. Out., London, Out., Can.) and RODERICK R. SiNGH. Ti'ansplacenUil passage of (femrlon In CE-i mice. ARCH ENVIRON IILA'Liir"~2o(3): i6f-163T"ilfusTT573."-T*'hu transpiacenial ixissage >f demeton lalx:lecl with radioactive phosphorus (^P) in pn gnnnt Ci -l mit e was followed auLoradiogr.iphically in frozen sections of fetal and placental tissues. The organophosphorus insecticide was mjeeted i.p. uii the 14th day of gestation at a dose or 5 mg/kg. Pla cental tissue, feUl muscle, and osteogenic mesenchymu were heavily labeled within 20 mm,, the radioactivity decreasing with longer periods of ireainigm. Jovrr iin oi pm ,Hed demeion maximally Ivtwccn ] and 2 hi. `The comjiouutl appeared to be rapidly metaliuUzed because fet.it tissues showed only trace activity after 3 hi. 9484, MC LAUGH LIN, MARTHA (E. I. ou Pont Ue Nemours Co., Ha da*ll Lab. T.-\n ol. and ii.d. Med., hlkl-*'. R--d. NewaiK. Del. M l:j>Ti,UsAJ ..i.d liURD iN J. .v 1 (HR'a. fn*" J m" ainMeae. ARCH O LNVlltoS RLAl.l'H I3l-i3ti. Lue smc.'kmg hatnts of >'Vel` JbUl) Du 1`oht eiuphyee, ui`l* Comp licit with then* ui me .md U 2 Ho livepi. 'I h* n`i an iii'inr Ho li-v*T- wei v found < < in 2r,i ,i f. Iiiei* fi*i n m.smoi.ci s, 2s.o,.ga liter for i igai eite sniouei a. and 2U.b,Ai'.' luei for pipe ahd'oi* en: ir siuomi rs. Mean blood I'o values weie 13.1 pg 1U0 ml, ib.JniViuo ml, and l?.3,ig.'ibu ml, rts(*emvely, for tin' 3 groups, |'he <Ul-t wore HUlnnitli-d to a multiple i ci're.SMun .). * 1VSl' 0* Iloloi /min' jf |||.> ihffi'i fin o:> Ih ,'I <1I|>S win e .1*. .i>'i.iloU v. 11 Ii miu >1. tin' Ii.iI ip , nj ,| t id li i 11 lit o! ntIn-1 v.l Japp' i, Nh f vuli'in r Cl foiiml to imlic.iti a MeudliMlil olli t t iif stti'iKlli;' on liliH.d l'|> |i m i hi jnfJuenLL- <J smokJO;: on ormo 1*1* levels, while stali'.in all\ sic- mf II .lilt, w.oi vet y Mil.ill Coli.g.il til XL 1th Uie lohvl Variability of tile lL-U and pitb.tllv of no luulo.'n'al significance. OLI 4957 i > t * I 29 [Jan., 1972] to 285*295 of si* TO* The bly iy UK.) 0$P gy h 'Since -on* ' cot- 1 ng ceo* arpom romi% tated SKOL . is* si* i 33 U is, Tagnk nVM* 3*d after 'boon 1. Kh, fane- l :H- i TW i irtn j theft ! ; 3janeei jolisx ytostf>nsio* i rved. ; 4lUf* . n lonaT A* I tiaJij . OTD .54. r.iC' of 285. PODLUZIINYI, P. A., and T. V. YAMICHAK. VIt\.inin m.tlykh a kontscntratsil krnsUciya sermxtwTO chistofcpiuhofrn "K" tu organism BPmFictwrlities dt Hcctrucardtcgrophic eluimcrda pmewts with vtnvl SlJoridcjtoij^ng.] tiki TR PKQFZADQL im u- -u-. J--H---A.--&CG * Thivotnykh (1-e jnxibshchemo). [The effect of low ''LViL llenertc vioyl chloride 0 eul/ur pure blue K on the animal botlv lTT Tfl I'KHM MED INST plieontof revealed cardiovascular disturbances mwtfesisd -as whangos X Vi: 145-150. 1970. Translated from Kfc.F ZH OTD VYP FARMAKOL ^ in rhythm sud np-|nHr`*^~ ym*abu *nii niacmtr ^ jJllMlOTER SREDSTVA TOKSIKOL, 1970. No. l0.54.622.**To set stan [ m systolic *U*.,jeCG dira ihrmfrt bs.uswf MMwmiae Ihs.ceadiUan dards for the concentration in the air at working places of an aerosol W tlm MMMnrattilBK U defree cd viayl dfeiMs potonifli i> a of the dye sulfur pure blue K, rats were exposed for 4 mo. by inhalation diticst.*C,>, to the aerosol at concentrations of 4 and 10 mg/m?. At the latter con centration 1 mo. of exposure caused failure to gain weight, hypoprotcine* mil and a tendency to hypoalbummemta. All the changes disappeared after exposure stopped. At 4 mg/m? no changes were caused in the animals during the entire experimental period. No deviations were found in the blood picture or cholinesterase activity. At 4 ntg/m? the aerosol had no appreciable action on the bodies of experimental animals under conditions of prolonged inhalation.--S, T. 292. ILTNA, V. A., and T. A. KOCHETKOVA. (Inst. Ind. Hyg. OcA cup. Dis., Acad. Med. Sci. USSR, Moscow, USSR.) Ekspenmenial'nyi !g. pncvmoskleroz pri vdykhanu aerozolei magnievolitievykh splavov, (Ex*** penmental pneumosclerosis from Inhalation of magnesium-lithium alloy X aerosols. I GIG TR PROF ^ABOL 14(2): 17-21. 197Q;7Enxl. sum.l-- Whcn inhaled, Mg-Li alloys have an irritating action on ths mucosa of the upper respiratory tract and pulmonary tissue and cause a number of changes in the respiratory organs. These include moderate catarrhal 286. BELOVA, S. F. (Inst. Ind. Hyg- Occup. Dis., Acad. Med. Sci. a USSR, Moscow, USSR.) KUnika porazhemi glaz, voznikayushchikh pri * vozdelstvli soedinenii eery. [Clinical picture of eve lesions occurring G under, the effect of sulfur compounds^] KLIN MED 48(3): 90*^271570. tracheitis, bronchitis, interstitial pneumonia, diffuse sclerosis and em physema of the lungs. The extent of the pathological process becomes greater as ths Li proportion in the alloy increases.--C. M, M, M [Engl, sum.]-''-The vision of til workers in the spinning shop of a factory a producing artificial fibers was investigated. HjS and CSj penetrated v the air of the shop in a quantity exceeding the maximally permissible concentrations. Occupational eye diseases accompanied by inflammatory manifestation* of the anterior region of the eye, ocular nerve distur bances and a reduction of the working capacity occurred in some cases. -C. M. M. 293. ZHDANEEVA, G. 8. O rentgcnologicheskikh izmeneniyakh v A legkikh pri intokslkatslt karbonil-nikeiem v ostrom 1 otdatennom period ic akh. fX-rav changes m the tunes with nickel carbonyl poisoning in the Jy acme ahast and lat.r.1 KAZAN MED ZH 1. 47-50. 1970. Treflated X from REF ZH OTD VYP FARMAKOL KHIMIOTER SREDSTVA TOKSKOL, 1970, No. 7.54.769.--In 5 men and 2 women (of whom 6 were 21-31 yr old and 1, 52) who had undergone acute poisoning from inhaling nickel 287. KUZINA, V. F, (Inst. Ind- Hyg. Occup. Dia., Cori, USSR.) 2 Materialy po otsenke toksicheskikh svoistv smaaochno-okhlazhdayshchet zhtdeosti NGL-205. [Data related to the evaluation of the toxic properties of NGL-205. a lubricatmgand cooling fluid.V GIG TR PROF ZABQL 14(3): 57*597 19 70.--The effects of NGL-Sij5, an oil solution of sodium sulfonate and passivators (water soluble corrosion inhibitors: sodium nitrate, trisodium phosphate and soda), were studied in rats. Acute inhalation poisoning (single 4 hr exposure at 200 mg/m?) resulted in increased gamma-globulin and albumin in blood plasma. Long-term inhalation (4 hr daily doses for 8 mo. at 42 mg/m?) produced chrome intoxication characterized by retarded weight gain, reduced 02 uptake, disruption of hippuric acid synthesis upon introduction of sodium benzoate and alteration of the ratio of protein fractions in blood serum. MetHb and Heinz bodies also appeared during the 1st months. Animals exposed to concentrations of 3-5 mg/m3 showed no effects. Maximum permissi ble concentration of 3 mg/m? is therefore recommended. Application of 5 and 10% emulsions of NGL-205 to the akin caused local irritation. A 2% emulsion had no effect.--C. P, carbonyl, observations were made of the organs of the thorax for 7-12 yr. &i the 2nd or 3rd day after the poisoning, a high position of the diaphragm was noted. Hie respiratory movements of the diaphragm were not determined or were limited. There was reduced air content of the pulmonary field. Two patients showed intensification and vaguesness of ths lung picture and of the roots of the lungs and the remainder also showed bilateral foci. Retrograde development of the X-ray changee began on the 7th-I2th days. The outcome of the poisoning was favorable in all the young people. Dynamic observations for 10-12 yr showed that they were completely recovered. Regression of the X-ray changes in the older patient was noted until the 29th day. The position and respira tory movements of the diaphragm were restored in 3 mo. The picture of the lungs and roots became as they originally were in 2 yr after the poisoning. After 7 yr the patient developed pneumosclerosis, cardio sclerosis and stage 1 respiratory insufficiency. Nickel carbonyl poison ing is probably not the determining factor in the growth of the sclerotic prccess. Us principal toxic effect is a disturbance of the lung capil laries and arterioles. Acute poisoning in healthy persons does not leave after effects.--S. T. 288. RYZHK. L. A. (Inst. Ind. Hyg. Occup. DU., Leningrad, USSR.) A Gigieniebtskaya kharaktertstika protsessa proizvodstva fol'girovannogo 294. OSETROVA, V. 1. Sostoyanie zdorov'ya rabochUch tsekha floto- a fttinaksa, (Hygienic characterization of foliated hetinax production.) " GIG TR PROF ZABOl 14(5): 12-15. 1870. [Engl. sum.|--Hygienic con tfitions of work and health status of workers engaged in the production Q fabriki Bereznikovskogo kaliinogo kombinata po dannym periodicheskikh zj meditsinskikh osmotrov. [The health of workers at the flotation compound T plant of the Berezovskn Potassium Combine, according to data from T flf hetinax and glass textolite were studied. Adverse factors, such as pollution of snvironmental air with acetone, phenol, cresol, formaldehyde sad ammonia and high air temperature were described. Some workers Z Periodic Physical examinations.! TR PERM MED INST '82: 88-90. 1970. Translated from REF ZH OTD VYP FARMAKOL KHfMIOTER SREDSTVA TOKSIKOL. 1970, No. 10.54.757.--Of 137 workers examined demonstrated functional changes in tht CNS and cardiovascular system. 70% were women, 50 had worked less than 10 yr and 77 more in the flota To remedy the situation, corresponding health measures were elaborated. tion compound plant of the potassium combine, The potentially occupa --C, M. M. tionally harmful products there consisted of higher aliphatic amines of fatty acids at concentrations tens of times the maximum allowable with 289. ANOKHIN, L. V., and T. K. MAKSIMOVA. (Dep. Pathol. Anal., O Voronezh Med. Inst., Voronezh. USSR.) Deisfvie etilbenzola na verkhnel G dykhatel'nye put! i mery profllaktiki pri rabote s nim. [Effect of ethyl y benzol on the upper respiratory tract and preventive measures during 4 U03CJ ZH USHN NOS GORLBOLEZ 30(5): 4-9. 1970. [Engl" sum.] a relative humidity of up to 96% and temperature in the plant of up to 30*C. The patients complained mostly of headache. Of those examined, 50% showed moderate tachycardia, dulling of heart tones, labile blood pressure and functional CNS disorders. Tenderness in the right sub costal area wag noted in 16 patients and urobilin was found in the urine --During the prolonged effect of ethyl bunxnl vapor (0.01-0,03 mg/1) altfratione chiefly of an atrophic nature, develop in the upper rt"*pir:inrv tract of the workers. In experimental animals ethyl hiMizitt vapor 10.Ut of moat of those examined. Equipment operators exposed most to amines showed an increase in the number of reticulocytes and thrombocytopenia. --S. T. mg/l) causes changes in the mucous membrane of the upper respiratory tract which are characteristic of catarrhal inflammation. At a concentra 295- MOZAN. C-, A. LACQUAN1T1, and L. PETTINATI. (1st. Med. tion of 1.0 mg/1. in addition to the chronic inflammation, manifestations Q Lav.. Turin, Italy.) Evaluation du risque mduit par les loxiqucs indus* cf atrophy of the mucous membrane with fibrosis of tho submucosal layer * tnels. [Evaluation of the hartards created bv industrial toxins.1 ARCH also appear. Preventive measures are recommended during the use of A MAL PR&F MED TRAV SEC SOC 31(3): 141-146. 1^0.-Tht means Mbyl benzol.--C. M. M. Z of evaluating the atmoepherie hazard created by induatrtal toxins that are currently practiced appear to be unsatisfactory and open to criticism. *90. BATSURA, Y. D. (Inst. Ind. Hyg. Occup. Dia,. Acad. Med. Sci. M USSR, Moscow, USSR.) ElektronnormkrOxkopicheskoe isgledovam* aero- X **m*tieheskogo bar'era pri pnevmoskleroze i emfizeme legkikh. fEIec- TT*> microscopic investigations uf the air-blot tl barrier m pnouny^c.cro* '^1*'T? p *>\ s e m \ .[ !{.* Il' RVL'LL FKSP Mt-O "VM' 113* 114. 19707rErigi. *um7]--L"'trastr Jfitural alterations caused by the drome effect of copper oxide aerosol were studied. A marked thicKemne ** the basal layer of the thin region of the air-biood barrier ana a rise 10 (8e number of eotiagenous flbera were observed in rats. These chang* ** *hay be considered as a structural basis of gas exchange disturbances * pneumoconiosis.--C, M. M. Results obtained with them are inadmissible. The problem of normaliz ing systems of sampling and quantitative determination of toxins is pres sing and essential. Well-defined norms should be given regarding the sn^ed of air sampling and the point or points where sampling is to be d'nc. In evaluating the risk involved, the phenomenon of toxin condensa* lu.n upwn difiereiu surfaces of wgrk are** which become secunc^rv sources of pollution must not be forgotten. The omy system appearing tu show this pan of the hazard is that of quantitative determinations m series, even at times when the specific risk is theoretically null, so that characteristic profiles for each work cycle can be obtained. Even * in this ease, a standard method should be used to obtain comparable and reproducible evaluations. This is the only way to obtain valid param eters of the hazard created by atmospheric toxins. These parameters are essential for a program of organized and systematic prevention. --S. L. R. c OLI 4958 717-729 II (Vol. 1 No. 1) 70 ON rcitt'neralion of llir noiioM'U znr was confirnwd hv tin- fiyjuTplmgncytic response noted during i>turly of tin* clm;nn`' of colloid.il z 773. SL'KIIAliKVSKAYA, T. M.. L. S. SAVKl/KVA. ami A. I. VOROTNIKOVA. (Novoslb. S.inK. Inwl., NuVfjftlb., USSR.) Opyt pri* Ca particles, A comiurnlilc result was obtained .liter Int mcncnlya -.iminok.ipronovoi klsloty pri khroulclicskol Intoksikatsll administration of tannic acid (2 g/kg of body weight).--3. L. it. bcnzolom 1 ego gomoiogami, | Experience usuu!_-.mnnoeapronic acid in chronic tmlsoninr with Immv/imU' ami its h<mi>|orui's.I (f|G TR RROF 717. CHMSTOFFERSEN, PER (Konmiunohusp., Copenhagen. Den,), 2 and KNUD NIELSEN. The frequency of Mallory bodies in liver biopsies from chrome,;tlcoholiclsr~ACTX ^ATlfQL11 MlCHQliidL SCAM) SKC1 X^A^H^L 79(3): 274-278. 1971.--in liver biopsies, from 287 consecutive chrome alcoholics, Mallory bodies were IouihI in 29. Of these, 18 had cirrhosis and fallv infiltration (corrcspondim'. to 44' Of the total number of specimens showing cirrhosis and fatty chance) And 11 (corresponding to 6r<) had fatty change Iwit no cirrhosis, while Mallory bodies were not demonstrated in biopsies without fatty change. The incidence of Mallory bodies and alcoholic hepatitis in consecutive 2XDUL l-l(Ia)! J'J-41. 'llTi'ufiTcd. 1971], --< -Ambiucapronlc acid, vitamins Dg and Bj2. glucose and Fe preparations were used to treat 12 patients with chronic poisoning by benzene and its homologues with symptoms of hemorrhagic diathesis. A hemostatic effect was obtained In 12- days in patients with mild symptoms of hemophilia and in 2-3 day days in those with pronounced manifestations of diathesis. In addition to the hemostatic effect, capillary permeability and the fibrinolytic activity of the blood decreased and blood coagulation time speeded up. The number of mature platelets increased after treatment and the num ber of old thrombocyte forms Increased.--N. L. G. materials of liver biopsies from chronic alcoholics appears to be 10 And 6*2 respectively. * 724. MAN'KO, N. N. (Inst. Hyg, Toxicol, Pestle. Polym. Plast. ASubst., Kiev, USSR.) Obosnovanlc predel'no dopustimoi kontscntratsll 718- BASALAEV, A. V. (Gorki Inst. tnd. Hyg. Oecup.Dis., Gorki, USSR.) Opyt prlmcneniya krupnokadrovoi flyuorogralii pri ossledo* vanii skeleta u rabotayushchildi v kontakte s neprcdel'nvrm uglevodorami stllenogo ryada (olclinami) i ikh khlorprolzvodnynii fkhiorvinll, trikh* idretUen). [Experience with the use of Urge-frame phoiofluoroeraphy ftn^examining skeletal bones of persons occupationally dealing with mi* saturated hydrocarbons of the ethvlenc series folchns) and their chlorine derivatives fvinvl''chloride. tnchlorethvlend.I GIG Tit PROF yxm 14(11); 34-37/ 1570; [Engl, sum.pxhese examinations re- p Fozalona v vozdukiic rabochcl zony. [Substantiation of iho maximum * permissible concentration of Fozaion in the air of a production area, oGIG TH PROF ZABOL 14(12): 4G-in. Ulus. I910|recd. 19711.--1The pesticide Fozaion (3-00-dicthyldlthio pho*phorylmethyl-6-chbroben* zoxazalone) caused decreased acetylcholinesterase activity in the blood of industrial workers in concentrations of 3.32 rog/m3. At a concentra tion of II mg/m3 in the air this enzyme is decreased by 3(77 in cats, which are more sensitive to the chemical. A maximum permissible concentration of 0.5 mg/m3 is suggested.--N. L. G. waled a definite reconstruction in the bones; osteosclerosis, osteo porosis, osteolysis and cystic changes. Traumatization of the limbs *nd prevalence in the clinical poisoning picture of these symptoms Aiggested lesions of higher vegetative centers, particularly of the hy pothalamic region. These changes may bc-of a neurodystrophic nature. Large'frame photofluorography may be recommended for roentgenologi cal examinations of the skeleton In occupational groups with potential bone'pathology,--C. at. m. 725. KHANIN, M. N,, and A. A. YULDASHEV, (Dtp. Pathophysiol, y Tashkent Med. Inst., Tashkent, USSR,) K mekhanizmu povrezhdeniya y deiitvlya gellotrlna na pechen'. [Concerning the mechanism of the * damaging effect: of hejimrin on the hvcr.l PATOL F17IOL EK3P TER 14(4): 60-63, 1970, [Engl, sum,[--Tissue respiration of various organs was studied in Warburg's apparatus after the administration of various doses of heliotrin to rats. With a dose of 120 mg/kg disturbance of tissue respiration was seen only in the Uver. LDcq and LD?o pro duced disturbances of gaseous exchange in all the organs studied. The 719. BRAKHINOVA, I. T., and G. V. SAMSONOV. Sravnttcl'naya intensity of metabolic disturbances descended In the following order; M ottenfca vliyiniya na organizm nitrldov perekhodnvkh metallov l neme- liver, brain, kidneys, intestine, muscle, myocardium and spleen. The _ UUov. [Comparative study of the effect of transitional metal and non- results of these investigations confirm the primary liver disorder * metallic nitrides on the body.] GIG TR PROF 7.ABOL 14(12); 4&-50. and aid in the understanding of clinical manifestations of the disease 1970(recd, 1971],'--In experiments with white rats nitrides of non- during the action of heliotrin.--C. M. M. metals including BN, S13N4, and BNC had weakly pronounced fibrogenic activity and caused pncumocomotic changes. Metal-like nitrides Including TIN, ZrN and NbN in addition caused dvstrophv of the liver And epithelium of the renal convoluted tubules. The recommended maximum permissible dose for nitrides of non-metals and NbN is 10 mg/m3, for AIN is 4 mg/m3 and for ZrN is 5 tng/m3. The toxic ef fects of nitrides corresponded to their electron structure. Their biological activity decreased with the increased possibility of forming ff2pf*Lectron configurations during interaction with N of non-metals And semi-metals and also d5-configurations with the formation of 726. ALEXANDER, J. F. (513 Med. Dent. Build., Regina, Sask,, M Can.), and ROSA ROSARIO. A case of mercury poisoning: Acrodyma in a child of 8. CAN MED ASSJ 104(10): 920-&46. filus. 1671.-- A can of mercury obtained from school had been taken home by 1 of the children of the family. All the children played with It daily in the house, the patient more than any of her sisters. The sensitivity of the condition to treatment with BAL [dimercaprol] was demonstrated by the high level of Hg excretion by the 4th day after it was started, as well as by the patient's clinical improvement.--,/, w. S. Bltridrt of transitional metals.--'N, L. G. 720. KARIMOV, A. M. Professional'nye xabolevanlya kozhl u 0 khlopkorobov, vytvannye yadokhimlkatami, i mcropriyatiya po ikh m profilaktlke. [Occupational skin diseases in cotton growers caused bv Z chemical poisons and measures for their prevention.! GIG th PROF f SXBGL'fiflS: 35-37. U70[kc<1. ISTiJ.-WrmiitiUs and .eiem* occurred In 30 persons out of 32 in direct contact with DDT and hexacbloratM. The disturbances were of a seasonal nature. Of 633 cotton Crowers, the skin was sensitive to the phosphoorganlc insecticides methylmercaptophos, octamcthyl and butyphos In 42'7. The time of development of sensitization to different ehemieals varied and depended po body response, concentration of the chemical, work conditions and the nature of contact.'--N. L. G. 721. AN. A. S., V. A. D*YACHENKO, V. 1. IVANOV, and A. P. 0 TALIN. Opyt medikanH'titoznoi proftUkilki porazhonii m'rvnul sistemy g pri lntoksikatsii ognestoikim mas lorn "Iwiur-3". [Experience in ? medical provrntlcm of If^Jurv to the nervous system tu inusouine with A Uic~flrfi)foot oil ~lvkip-\1 GIG Tit 1'UOK ZAhiJlhTT^F-3V-3J. l70|recd. 1971).--Person* working without gas masks in the remains Of a breakdown at an electric power station were intoxicated by the dimes of *Tviol-3", a compound based on trixylcnvlphosphate, vitamin E, vitamin B$ and phytin was effective in preventing damage to the nervous system,--N. L. G. 722. ELI5U1SKAYA. R. V. Sostovanie plodov Rost! u rhivntnvkh Q nrl khronlch^rkom verd-'ir:* ii yar"v "v ' '-iis-t-'i--i1'* ''On. km``n'*pon ^ of fecundity in animals sub!'Vt**i| to cr.:*c.ie i; t.J ; `a ii. * o - _ wll*toV`iu~lunios. j biki ii( PROP Mi'UL IJ1; l'R/J'recd, O 1371].-hitc"rats (45) with strietlv periodic oestrul cvcles were ex posed to the fumes of metadiisopropylbenzcne in concentrations of 0.2 mg/1 and 1 mg/1 5 hr daily 5 times a wk for 5 mo. The course of the sexual cycle was disturbed with characteristic prolonged flow. The capacity for conception was substantially decreased. The average number of offspring decreased as well as their weight. Gonadotropic effects of the compound arc indicated. Women's work in the presence of this compound should be regulated.--N. L. G. 727. SLONTTSKAYA, N. N. (Leningrad Res. Inst. Antlbiot., Z Leningrad, USSR.) Toksichnost' levorina dlya beremennykh krys i ploda. [Toxicity of levorin for pregnant rats and fetus.1 ANTIBIOTIKI 15(12): loey-ldvj. IUus. 1970. (Engl, sum.]--The drug was given orally in doses of 1000 , 500, 100 , 50 and 10 mg/kg, Levorin used In single doses of 1000 and 500 mg 'kg induced abortion and death in name rats. Administration of levorin in a single dose of 100 mg* kg resulted in abortion and postimplantation death of the fetus. When the antibiotic was used repeatedly in the above dose, abnormiUties in the fetal development were observed. The abnormalities were associated with non-union of the peritoneal wall and prolapses of the colon loops. In some fetuses abnormalities in the development of the eyes and cranial bones, brain were registered. On repeated use of levorin in a dose of 10 mg kg abortion in some rats and postimplantation death of the fetus were observed. The level of the toxic effect of levorin was in direct proportion to the dose and the period of the drug use.--M. F. 728. SILVA, NEUZA O, G,, and AMAURY T. L. ANDRADE. 2 (Fac. Med., Univ., Juiz de Fora. Brazil.) The effects of thiophemcoi upon the rat conceptus, FERT STERIL 21(5): 431-433, 19<0.-- Albino pregnant rats were given thiophemcoi to determine the effect of the drug upon the conceptuses. Thiophemcoi was administered l.p. (100 mg/kg of body weight) from the 1st to the 7th davs of gestation on an every other dav basis. The treated rats and controls were sacrificed On Dav 19 or 10 and were examined for resorptions and rv-li.rnja'iur-. 7h"re was a ytausncallv i:-uf;can; number or resorptions in the thiophemcoi group, the incidence oi abnormalities was low in comparison to the number of resorptions. The results strongly suggest that the drug has a potential!} deleterious effect upon the rat conceptuses when given in the first 7 days of pregnancy. --M. F. 729. LEBEDEVA, A. F., and L. A. MAROKUSHWN. fSanit.-Hyg. J Med, Ins., Leningrad, USSR.) K voproxu o mekhantzme narushemya funktsll nervno-fnyshechnogc appiraU pri vozdetstvil vlbratsu. [Mocha- OLI 4959 IRfQUtHCV 0* ah* TDkIN ANO ISfiKlllUt IN HH'UW HU- PMQOUCIS -tUAT'M My (tvt-.il COMN-N R|Al' NOUOLCS fMU|7 PRESERVES LtCU*t-Q -l*0/4*7 Hut inviu* 1*94 paulei c CHfvM i EFFECT OF COBAlt ON CARAON NON 0*I0E 01 IDKI f 11A11 ON/ RAARIT HtNO CL001N AiO0*0 >Jv*0** PAGE llW-1202 lB*T HAUAtL f BOUtSiOu h (ARIFS J iON EFFECTS Of INDIUM POISONING ON ThI NEUROL ISM OP UREA/ AAr 7*407*4 PAGE 1124*1227 issi monjour i naoiacc c INTERFERENCE QF AFlA lOlIN IN IhE PROTEIN SYNTHESIS OF THE *At Th( PftQiiE* 04 NtO AN11GENS/ ASPGILLU$-FLAVU$ AAA 11 IMMUNOLOGY CANCER -1*024*2 PAGE 1291-125* Hit monjour l na{age c St*U* ESlIAASES AND AFL4 TCHN/ -RAT NEPATO CAACINCNA IMnuNCLOGY NtO ANTIGEN PROTEIN AIOJTNThESIJ 1*02412 PAGE 1241-12*5 J AM MEO ASSOC 214 1121. INTO 1*40 OOTT A A BLOOD ALCOHOL LEVELS AND INTOXICATION/ .LETTER HUNAN -44175 PACE 2194 ElPERlINTtA llASELl 24 141. 1470 1*41 YOUNG M THE MECHANISM OF TEIACDC TCx|N ON THE IN-SHU ACETYL CHOLIN .ESTERASE IN THE VAGAL hART StSIEM OP RANA-PIPTEN|/ /pupper pish -11005*99 -- PAGE 992-991 1442 ROSTIl J N4CHACR0VA I jIRaCEX V AUCHAR E INFLUENCE op SULPUR 01 CMOS ON The CONTENT OF p*ce SACCHARIDES ANO AMINO-ACIDS IN SEEDLINGS OP PEAS-Q/ .ALANINE GLUTANlC-ACtO TOXICITY >74*4095 PACE 404-405 .1045 THOMPSON J M SPttl* C A ANGULO N CHRONIC EFFECTS OP NICOTINE ON RAT GASTRIC SECRETION/ IOAACCCH0 SNORING PEPTIC ULCER ETIOLOGY 5*ll9 PACE 415-417 .1*4* RAR P p DUSMiTh T S S OiRRAL TOXICITY OP DOT/ GUINEA-PIG INSECTICIDE SRlN AMINO-4CI0S ChroNATOCRAPhV CTTOLOGICAL STUDY *90291 PAGE *)*-4S5 1*49 C*M/RCH|LL P C SECRET ION OP RENIN IN ANESTHETIZED RAIS' AASTRACT PARA AM(NO MPPuRK-AtID PENTC BARS174L CENT-OfPRESS-OiUG RINA* PlaSma PLOW . PAGE 479 OiBAGtNEUX 29 (121. L970 L*47 EMAVIO* OP DETERGENTS IN COASTAL .abstract pish qegmaoaticn PAGE *A1 BOCt R 4 N1CRBCL0 A NATHS/ ,BECRADAAfiITT CP NON-IONIC TENSIQACTlVf COMPOUNDS PUR IP1CATION INSTALLATIONS/ ^ABSTRACT VAIER PAGE 411-4*2 * IN MTMOIIOL J 5 111* 1*49 .LA** -MILOVIOOV4 N *10**91 4N0 RFSfAvfS OF H4CRC 100 AFNIhCS IN IHF 44vs (IF IHf NOR IHfA St E RN PAR? 01 THf 414(4 SLA/ DISlRIAUTlON POLLUTION PACE 15-1* 1 t*49 SlNEl HltOt V f MI4H4VLCV V A 'TH( OUANTIIAMVf Of TI *N 1N4 T | QH QF WATER SURFACE POLLUTION -VIFh AIIUMENOIOS/ EP-LN fLUORIMlIER LUMINESCENT PETROLEUM FRACTION RESERVOIR -M1400205* PAGE 41--4* IAT* IL V|N t H MARINE AQRERS FROM OUR LlltRAtURl/ fllEDINIOAE A S AONSTANIInOv CRITIOUE 01St{*utION CONTROL ECOLOGY PACE ti-42 LA* PtACt IF ( 121 l4V .1*71 MENON I S EFFECT of CARBON Dl OXIDE INHALATION On alooo FIVRIMOLTIIC * AC 11V t T Y / HUNAN 12*149 PAGE 12*4-12*9 /*" (VtW I N, HPiRICNflA IAASCL) 24 ill). 1470 UU 1 ATS 1AT4 TiAA s C*l U 7 I c 01 HOOKA c ELAVONUIUS 0) CNAPHAl It A) -D LI ONtUPOOlUN-AlP1 NUN-0/ CROC mouse toxin Chromatograph* PAGE 1142 RATO H tUZORl T STRUCTURE OP IRaOV RININ POTENTIAT|NG PEPTIOE CONTAINING TRYPTOPHAN PXOH THE YENCN op AGKISTAOOON-MALYS-ALOHMQFFtI/ PAGE HOT'120* OUCRETT S PETAL ENCEPHALOPATHY FOLLOWING INCfSTION OP TELLURIUM/ RATS -10024147 PAGE 1219-11*1 2 PEOtATR l4****T*4tA4a>A. *1949444444*a****4444*A4**a**4K44**a#*444***4*< 1179 NCNtCHOLL * RILROt R TRANSIENT HYPERTENSIVE ENCEPHALOPATHY POSSIBLE RELATION TO LICORICE/ CHILD CLVCVRRMJttC-'lClO -1*05441 PAGE 9*1*944 4fHMHtP*fMIH**4*t*flHMM**UH*fM***tH*****nMIM****IM*fl N|0 ANN 0 C *0 III. 1971 1*74 SILVER M M CARACA MON CUBE IN HEALTH ANC POLITICS/ mi HUMAN SNORING AIR POLLUTION 4)0040 PAGE 1*^111 ******#************* MRO J 91 III. 194* isrt 1ST* BQVAC A PAAAC b RlJMAJlt* L JU*IC-*U21C D ACRQPAfMlA ElTRfMlTATUN IN POLYMER|S*TIONE YINYLCHLORIOI MEM OCCUPATIONAL DISEASE/. HUMAN EXTREMITIES BONE CHANGES *OLV YINt CHLORIDE *PM9002*42 PAGE 1*12 MARK ICE VIC A an unusual syndrome op acaopathy as a men occupational disease/ human extremities PAGE TO-TJ A********************4********444444********** C SEANCES lDC RIOL P|`l 1*5 (At* 1949 1079 10B0 10*1 1A47 |l|l 1** v 1**9 lit* MONJOUR L M4AUGC C ENMV6MIC ANTIGENS ANO APLA TOXINS/ BAT HEPATIC CARCINOMA TfMATOGENESI$ -1*024*2 PAGE 12AA-U90 BUUTON C MAfLLfT N FlINTuCH N 4 STUOY OP THE EFFECT OF G!AACAELLIC-ACtO (M AQULT MALE CASTRATEO RATS/ STEROID PRECURSOR GENITAL ATROPHY *77045 PAGE 1102-1504 OOUOICR A ROUSSEL * GODIN J STUDY OP THE CEREMAL CAPILLARIES DURING THfi CONFINEMENT OP MICE/ CARACM NON CXIOE CARAON 01 OXIQt POISONING NlURO SECRETION MENINGEAL CONGESTION SM DIFFERENCE *12*5*9 -*100*0 PAGE 1104-1509 GUERIN M NALL0n G (PPCCfS OP TME SUBSTITUTION OP CESIUM POM POTASSIUM IN THE PERFUSION LIQUID OF ISOLATED TORTOISE HEARTS PART 2 AAiANCE CONDITIONS AT VARIABLE RELATIVE CONCENTRATIONS OF POTASSIUM ANO CESIUM/ CELL CESIUM ACCUMULATION TOUCHY >7*40*42 PAGE IS24-1527 CARA M C0LCIER6 A POISVfiRT M CARA G STUOY OF THE EFFECT OF A VALO DILATOR ON CONVULSIONS CAUSED *Y HVPCA AR|C CXYGCN/ MOUSE HVOl*C!Nt AN| Ibolf-QRUG *101*75 -7742**7 pact 15*0-1141 L41UNT i FRVYSSlNtt t MVCO 70HMS PMOOUCID AY 4VPCRGILLUS THEIR EFFECT ON CNlCR fcMARYOS/ TERATOGENS PAGE 11*2-114* ARISOU J DEMIS F USE OF AACTIRIA TO DETECT CERTAIN PESTICIDES/ FLAVU*ACtt*(UN AACULUS-L ICHLNIFOMNIS AM|N4L SMLL V(4 BAtfR PAGE 1*24-1*27 RfRCHMANN ROCH G LAFGNlAIN( A VAN OfN HOER 4 IRITIUM 7A4NSFEA AND OISUivuMOd IN I Ml S4IN CONST 110f Nl 9 OF MILR FROM CCvS FED HllM CCNI*m|N4IEO NAT4R 10024114/ PAGE 1*59-1*4) (ftPfe M1LNII 4 (AAStLI 27 111. 197| 1**7 GHIMARDt P MARCHE T 71 G MARIO A SAAQlNI 0 Changes in intestinal aisorption of glucose in rats N|Tn ETH4NCL/ ALCOHOLISM SIGNIFICANCE -9099' -N*l79 treated OLI 4960 itjfCb, ^ 972) /J 2277*2267 nuot :i* cmlrin, chliM'dam*, m rhJm lu.Ui i| lu- '* detected Lxi the wpcrlmcn.s .HMlyzed tiuriiii', thin m- * , M* M. ,|7 MIKAEI-YAN, E. M,, and V. G, MKHITARYAN. (Yerevan *' \t ||utf( Yerevan, USSR.) Sdvigi v sodcrzhami ammlaka, a armdnykh grupp bolka (lcgko- 1 trudnogidrolizucmye) k" kry* Pr^ khloroprenovom otravlenu. [Shifts in the ' ` of ammonia, glutamine and the amide grtxTps nf proteins, ' j'Tirnivzf'd and not easily hvdrol\acdr"m the l>r,,un of white ;with chloroprene, | BIOL ZftrAHM ^ 'rrmte rats were poisoned through inhalation of chloroprene i r 2 hr. The concentration of chloroprene in the ehamber was ` The periods of poisoning lasted 30, 60 and 90 days. As a '."t throttle chloroprene poisoning, the concentration of free ??n?. KAMIYA1', S. K. (MMiidla liml. MinI. Jlrl., N<-w Dr|)il, i>< tIi 1. hnll.1.), and fJ. K. fiUl'TA. 'ni'^dlvri of jK-ru^nllonul `*x{i*Rurn_ O to nrjjaiv^linwpJioruH on IiJihmI ehohnosirr.iM^. INDIAN .1 p RED UVS "69(2); '25^*293. niJ5^197f7^Hr.sults o blood cliolines* r terase activity measured by timomctric method In 158 males of Delhi Z and Punjab, including 84 occupationally exposed to*organophosphorus pesticides and 74 unexposed persons were reported. The blood cho linesterase |ChE] levels in unexposed persons were in lower range in comparison to values reported for European adult males. The ex posed group of individuals showed significant depression^ cholines terase levels as compared to that of normals. A significant relation ship of blood ChE activity with the total duration of exposure, the time since last exposure and the presence of symptoms In the occupationally exposed persons were observed. i .i tf> the brain increased significantly, while the concentration ' vA.4p|( decreased. The concentration of readily hydrolyzed ' . groups of protein scarcely underwent any changes. Amide ^ s! protein that were not easily hydrolyzed increased by 50^ 2283. KAW, J. L, (Inst. Lufthyg, und Sillkoseforsch., Duesseldorf, W. Ger.). G. S. D. GUPTA, and S, H. ZA1DI. Lung lipids and oulmon- z Arv stbeo.is In riB, 1NT ARCH ARBEITSMEb ili-Sii. tllm. '>1 days of poisoning, decreased by 60 * after 60 days of poisoning timed to normal by the 90Ui day of poisoning. An increase jCf?e of amidization of proteins is a defensive reaction of the to the toxic action of such high concentrations of ammonia. t, 3rd mo. of poisoning the organism adapts slightly to the actioif , c-Tcprene.--L. K. R- ypl, SATSSKKO, L L Obmennye reaktsii v organizme v usloviyakh ' w t/be*koi intokfUatsLi okis'yu ugleroda. fMetabofic reactions in w .-r under chronic carbon monoxide poisoning. 1 /AKTORY -Tiaiirfpy ZMTCH Ehll:Zt>CR5V,VA KAmEKlYA RESP 1971.--In the develnpiii.nt of pulmomrY tlllcoiii in rat> nudies on ehanKs in the total, titertfled, free choleaterol and phoapholipids wre made tn lung*, liver and blood plaama over a period of 200 dayt. Total cholesterol, its tractions sod phospholipid content increased with time in the hugs of silicotic animals. Hiatochemically sudanophillc materials were observed in the cytoplasm o( pulmonary macrophages. Changes similar to those of lungs were not observed tn Uver and blood plasma; the increased lipid content ol lungs during experimental pul monary silicosis may be due to the localized degenerative action of silica on macrophages, i;`4YFD SB 2* 146*149. 1970. Translated from REF ZH OTD - * rAKUAKOL KHIM1DTER SREDSTVA TOKSDCOL, 1971, No. 2.54. were subjected to the chronic action for 9 hr daily of CO * * 'mrmtratiCB of 0.009-0.018 mg'l for 1.5 mo., at 0.03-0.04 mg/i - ester3 mo, and at 0.08-0.1 mg l for 1 mo. Under the action of *- T) itere waa a persistent increase in the concentration of total in the blood.--S. T. f*7f. PERRY, R. MITCHELL Jr. (Wash. Univ. Sch. Med., St, 63106, USA.}, ELIZABETH F. PERRY, and JAMES E. ' OOY.AnUnairhiretic effect of intramuscular cadmium in rats. *i SOCEXP BIOL MED 136(4): 1240-1244. ILhifl. 1071."-During * zw ity after an l.m. injection of 1 mg of Cd/kg of body weight. *'-^1700 g rats averaged 42 pEq less urinary Na than control ani* < This aminatriurctic effect increased with successive dose* of v *4dUng an average of 68 jiEq after the 4th such dose. There was -rwtpmding increase in weight on the day after each Cd injection. Ts ii mil jin mi was observed 1 and 2 wk after the 1st dose of Cd. r * ** Ins evident after the 2nd dose and was complete lv absent after * Hand 4th doses. Cd produced no corresponding change in urtn* * *:ten>, protein, K, Cd or Zn. Six months after the 4th Cd injec*rv was tto hypertension but there was a suggestive, if insignifl* acraae in peripheral renin and a decrease in responsiveness to " "uwiiub* but not to either angiotensin or Cd.-^. M. M. 2284. MUELLER, W., and G. HOLZAPFEL, (Inst. Arbettshyg., Univ., Jena, E. Ger.) Ueber die Bezlehung swtschen Detta-AmlnolaevuM UnsaeureYtusScheidung 1m Harn und Blutbleispiegel bel Arbeltem roll -- unterschledUcher Blefexpositlon. (The reutionshfo between ALA In w urine and lead In blood in workers with different )eadexposure,I INT ARCH ARBEITSMED 27(4): 331-337. Ilius. 1971. (tngi. Sunim.) --In 3 groups of differently exposed lead-workers the relationship between ALA (gamma-aminolevulinic acid] in urine and Pb in blood was in vestigated. This relationship is not constant and depends on the kind and Intensity of exposure. It Is difficult to establish an acceptable Umlt value of the ALA-output tn urine. Women seem more sensitive to Pb than men. 2285. BASALAEV, A. V. (Gorki Inst. lnd. Hyg. Occup.Dts., Gorki, USSR.) Opyt primenentya krupnokadrovoi Ilyuorografti pri ossledoO vanii skeleta u rabotayushchlkh y kontaktc s ncpredel'nymi uglevodorami j ttilenogo ryada (otefinami) 1 lkh khlorproizrodnymi (khlorvtnll, trikh-- loretilen). (Experience with the use of large-frame photofluorography in examining skeletal ttones ot persons occupationally dealing with unsaturated hydrocarbons of the ethvlenc series (olefins) and their tttt. CANDURA, F,, G. FRANCO, and U. P02Z1. (1st. Med. s -m *-2ntafr, fiassari, Italy.) Influenza del calore auirattjvita '^ritaiasiea eritrocttarla nel coniglio e neU'vnimo. I: Indagini * ***tautone da piombo. /Influence of heart on th<* AlA-dchy* *, `-^^^rvtlMrocyte activity in the raF&it and man?] LAVOHO UMANO ''Jo, iikui. 1971. (Engl, summ.j--Tfte Uulucnce of heat on delta *" ^vitalc acid (A LA}dehydratase in rat, rabbit and man, both in ^*'1 totetfiimg and under Pb-intoxication, was observed. Innormal' *^*.tbe rat was unfit (or the investigation. The activation process *t treatment differed in rabbit and man. A reduction of chlorine derivatives fvinvl chloride, trlctilorethvlene).I GIG TR PROF ZABOL 14(11); 14-37. igfo. [Engl7sum.|--These examinations re vealed a definite reconstruction in the bones; osteosclerosis, osteo porosis, osteolysis and cystic changes. Traumatization of the limbs and prevalence in the clinical poisoning picture ot these symptoms suggested lesions of higher vegetative centers, particularly of the hy pothalamic region. These changes may be of a neurodvstrophic nature. Large-frame photofluorography may be recommended for roentgenologi cal examinations of the skeleton tn occupational groups with potential bone pathology.--C. M. M. *** ****** ** rabbit and an increase was observed in man. * ^*^^*0*flatten, an increase of enzymatic activity was .shown ** lack's as a result of pre-heating.--C. M. M. /!!,* 'JfcKEUClU, ."'CORO. AKIRA TAKADA, YOKI HO KATC). ' ,."l'sulltURA. FUMIAKI IKK:cAMI. and YOSHIRO MATSUl'A. Kaniuua t'nlv,, KAnaia*a. .rap.) Hi'iatic cAamy. in ` L*** (oUo^nc periodic acute alcoholic intoxications, t * ^NUTr 24(G); 62b*63C."illus. 1971,--Rais consuming * alcohol mixture in their drinking water, received - . ,f#hilof a 40*^ alcohol solution/lOO g body wt once weekly * * ^ Jj* Production of hyaline bodies, fatty change and elevated ' * ghitamic oxaUcetic transaminase activity were all 't* ran consuming alcohol chruniealli and acut-'K c.w*ble than in th-'rats ccijumi.".: it ^1- chrrv.-aii*. -".Je -rL As the total caloric mtakr and tlir* calunc pr<UMnious the total caloric iniakr were virtually ui* .uuai m both `*,,^?rfTXC05 ^ hepauc lesions and lunenwn .vert1 attri*cllon of acutclv administered alcohol. The hepatic 2288. BRAK1HNOVA, I. T., and V. SAMSONOV. Sravnltcl'naya ilM-nti vltvantya na nrg.ini'/nt nitn (vrrkii.KinvLJi nu'tallov l nemt'- M (ullov. jC<ihip.ir;iltvi* study of iM ol Ji;msUUmal ivot.iJ .itul nun- X miM.ilhc.nUntjrs onllw JxHiv.T Glo IK IMlOT /.ATlUL H(12): 46-50. 2 I970[recd. 19711.--In i\\porinii?nt* with whitf rats nitrides of non- ^ metals tnc* ling BN, SijN^, and BNC had weakly pronounced fibro- cenic activs.y and caused pncumocoraotic changes. Mctal-Uke nitrides Including TiN, ZrN and NbN in addition caused d\strophy of the liver and epithelium of the renal convoluted tubules. The recommended maximum permissible dose for nitrides of non-metals and NbN is 20 mc/mJ, for AIN is 4 mc/m3 and (or ZrN is 5 mg/m3. The toxic ef- fee*s of nitrides corresponded to theu electron structure. Their i;- .! artlvitv d-'crca/cd with the increased possibility of forming S2!)0*oh>ftron conncurations auruu; interaction with N of non-meuis and SL'i-.-.i-mctaiji and ab*o d^-A'onfi^urations with the formation ol nitrides of transitional metals, --N. L. G. - rat< semlsynthetic diets were more prominent than w *< a commercial diet. Hyaline bodies can be pro* * *v rf^'m<,atally by administration of alcohol. The severity of `v, 1**^ chanpes is related to the manner of alcohol ingestion and 2287. KARIMOV, A. M. Professionarnye sabolevaniya kozhl u khlopkorobov, v)*vannyc yadokhimixataml, i meropriyatiya po jkh profilaktike. /Occupational skin diseases in cotton grower* caused by OLI 4961 V 3JO TMf ANALYSIS 111 MM) rMICtfNtr OAIA AS AllATHl io varunis DlMi u A( t A 1IIA If IIS I S IN L,U(fe|Nl. SYINI/ AltMRACI L|Y|R INJURY HUMUS 14024R/ 2*49 3170 PAGE J91 r<B1RG G S COtOWIU * TMNMfKH m L TmE DlVflOPHlN? 01 A SVSTfHAMC NtTNOO FOX T0|COlOii 1CAL RESEARCH USING AN INIEGRATID MULTI DISCIPLINARY APPROACH/ ABSTRACT ANIMAL ETHANOL BARBITURATE OKUG INTERACTIONS "A*I79 *TS27 RAGE 741 NAATNAN H HRAt R CARTY R A VERSATILE DATA PROCESSING SYSTEM OEYiLOPtD FOR ANIMAL EPROOUCTION AND TERATOLOGY DATA/ AISTRACT COMPUTER PAGE 241-292 1171 YOURILIS G J MORROW R J PORNEY R B ACUTE CAROIQ VASCULAR RESPONSES TO CADMIUM/ ABSTRACT RAT CORONARY VASCULAR RESISTANCE MTQ CAADJAl CONTRACTAL FORCE CATECHOLAMINE RELEASE >74404*9 PAGE 292-291. 2*72 CRESS C R LARSON I ICAO ANO LINDANE INTERACTIONS ON MEME SYNTHESIS IN THE MOUSE/ AISTRACT HUMAN PESTICIDE ANEMIA ENVIRONMENTAL CDNTANlNATION MEMO ClOB IN *1(199 *7419921 PAGE 29) 27| BtOvN 0 R MURPHY S 0 2(74 29T5 INFLUENCE OP ACE SEX AND HORMONES ON TRI ALKYL PHOSPHATE INDUCED NARCOSIS IN RATS/ ABSTRACT OIMfIMOATC PESTICIDE NARCOSIS *40519 PACE 79J-294 CASK INS J R MH|R R N MCCAULEY 0 P LICON I w JR ACUTE effects OP CHLOROACETOPhENONE and ORTHO ^ CHLDRDSENITLSDENEMALDNDNnMvE IN RATS ANO RABBITS/ ABSTRACT TEAR CASES CASTRO ENTERITIS CORNEAL IRRITATION PURPURA NECROTIC ESCHAR *2494411 *114124* PACE 295 ALSTCTt R i BROWN 0 J PORNEY R B CNEYMATlC ACTIVITY PATTERNS IN TMf RABBIT AFTfB CAPPfINE ETHANOL ADMINISTRATION/ ABSTRACT SMOCK AVOIDANCE *0* *5*0*1 *44175 PAGE 294 2BT4 KlLlENS R L DOMBKOSKI f NCmOERSON M P CAMPBELL R I EFFECTS OF NITROGEN 01 QUO! ON ENZYME ACTIVITY IN RAT TISSUES/ ABSTRACT LUNG LIVE* RIpNEv HOMOGENATE! ALDOLASE LACTIC ftCMYOAOGCNASE ALKALINE PHOSPHATASE *10102440 -PAGE 294*297 2*>T WATKINS W 0 TEPHLY T R LIVER ALCOHOL DEHYDROGENASE AND RETINAL ALCOHOL DEHYDROGENASE/ ABSTRACT RAT ALCOHOL CHROMATOGRAPHY OXIDATION TQxKItV *44179 PAGE 797 2ET0 BACHMANN t COlBERG L D1GUC0NO P MITOCHONDRIAL EFFECTS OF ETHYLENE GLYCOL IN-VITRO ANO IN-VIVO/ ABSTRACT RAT DOG NONKET MACACA-HULATIA ELECTRON TRANSFER OXIDATIVE PHOSPHORYLATION *107211 PAGE 297*791 3179 POWERS J H NICHOLS J MEMNtCAR C R JR DOUGHERTY W J IBM ULTRaSTRUCTuRAL MlSTOCHfMlCAL CHANGES IN PUREBRED CANtHf HEPATIC CELLS FOLLOWING ACUTE FEEDINGS WITH 000/ ABSTRACT dot PER Thane INSECTICIDES P(NTC BARBITAL CCNf-QCPRCSS-DRUG ATPRSI TPNH OIAPHORASf T24SB -74744 *90291 72540 PAGE 299 MACKAV C R GtOTH. 0 H MfiO M L LIGHT MICROSCOPIC ANO ELECTRON MICROSCOPIC StUOtES OF BERYLLIUM HYDRO*IM INOUCIO RAT PUlNONARt TUMORS/ ABSTRACT *1104490 PACE 299 2M1 VOCIN I E PECK H M CARSON S NORGAREIOCf 2002 2 year Chronic toxicity stuoiks him moieties of nicarbazin/ POULTRY 006 RAT HUNAN SAFETY LEVELS *110990 PACE 244-100 BQYO E M 100 OAV LOGO INDEX OP CHRONIC YOXtCttv/ ABSTRACT RAT ATROPINE PILOCARPINE ASPIRIN PHfNACETlN 2002 2004 paracetamol SUCROSE SODIUM CHLORIOE CAFFEINE OICOPHANE PESTU1DI ORAL *90793 *57901 *90712 *42442 *91990 *90002 101402 *7447149 *42117 PAGE 100 NANttN m H COlllNI T P I GRAHAM % L JACOBSON K H CHRONIC ORAL TOUCHY OF IBYtmOSlNE IN BATS AND GlBBUS/ ABSTRACT DIET YHViOlO FUNCTION *114070 PAGE BOO-lOS LEYINSRAS 6 J SHAFFER C B 2BB1 2004 TOXICITY OF ABATE A MOSQUITO LARVICIOt R*C US SULFOXIDE/ ABSTRACT RAT RABBIT MEN OQG *11499*4 PAGE Ml-202 GOUGH * j SMELLINOfACER T C IUKVIVO EFFECTS OF 0*IMt REACTIVATORS ON 0R6ANQ PmOSFnATE inhibited blood Cholin estebase/ ABSTRACT RABBIT Pa6( 101 RAM* SAURY v CmIOu C v SOME ASPECTS OF TMf BLOCKADE OF NEURO MUSCULAR TRANSMISSION BY 1000 ACETATES BROWN ACEUttl ChlORO ACETATES AND *LUO*0 ACETATES AND TMCIK CHOLINE esters IN THE RRT PHRENIC NERVE DIAPHRAGM PREPARATION/ 2(47 abstract d ru#o curarine antioote-drug 4449T *740(9 *79111 PAGE SOS COHEN S 0 "UR*MT J D phvsostignine maaayo DOSE ANO TIME RELATIONSHIPS FOR CARBOXYL ESTERASE INHIBITION AND NALATHION POTENTIATION (V EfMVl-P-N!TBO*hINYiTn|CmO-BEN/EV* PhOSPh:laTE 0*<T"TL*-0**-niircphENyl ph/nv TNjr*TF a47- an/. PAhilHlCN/ ABSTRACT MOUSE USCCtlClOES *2104449 -))B)9I *943? .121735 PAGE 201*904 2BBI LOCAE I ft BECK V BARON R L METABOLISM OF CARBAMATE INSECTKIOCS UT III I INC CELL CULTURE TEChnIOUES/ ABSTRACT L-llI Human fNBRTD LUN& CARBAAYL BANOl UC**0*4 N-*-N MCIhYL CARamoU0T-O-OIYL*N N 01 METHYL FORMAN]DIME TIOKf *17702977 *A1292 // (VtL I Ng PAUl >04 2BB4 JUAU X m ----- OfeONRA M 4 *M#"FM TOXICITY STUDIES ON POLY VfMW CtOMTOt PPRNW.BTI#t OP OlMAMDNYAt/ ABSTRACT ANTI HELMINTH GAllRO INIESriMAL TRACI *A271T PN4D024A2 PACE SO*-IDS 2A90 smallty h f radueff i o c COMPARATIVE TOilCItY OF the herbicide paraquat IN LABORATORY and FARM ANIMALS/ 2141 2*92 ABSTRACT GUINEA-PIG HAMSTER SHEEP SWINE PNEUMONITIS DEATH 4*49147 PACE 109 STEWART R 0 PfTfRSON J C BARETTR f 0 EXPERIMENTAL HUMAN EXPOSURE TO CARBON MON ORtOE/ ABSTRACT CARBOXY MEMO CiDBIN *4100*0 PAGE 109*104 MANNO J ( FORNEY | KIPLIN6ER G * BENNETT l HUNAN MOTOR ANO MENTAL PERFORMANCE UNDER THI INFLUENCE OF ALCOHOL ANO OR MARIHUANA/ 2P91 abstract oelTa-b tetra hydro cannabinol Chromatography **4179 FACE >0* CARTER V LJR FARiffl 0 N BACK K C THE EFFECT OP MONO TRIFlUORO HtTHANC ON OPERANT BEHAVIOR IN MONKEYS/ ABSTRACT FlRf SUPPRESSING AGENT *TS*2 PAGE SOT 2194 MILLER 0 WAN LOON E J MICHEL T C OLIVITO V L CENTRAL NERVOUS SYSTEM SUPER SENSITIVITY TQ CHLORINATED PESTICIDES AND PfMTVLlMfTITRAIOLC AFTER CHRONIC BARBITURATE 'ADMINISTRATION/ 2099 ABSTRACT 006 OICLDRTN LlNOAMf PHCNO BARBITAL CONVULSIVE ThREStOLO *40571 *90099 *50044 *54999 PAGE >07 SINGH J M PRA1QID L EFFECT OF ATROPINE ON PESTICIDE CARBARYL 1 NAPHTHYL N-METHVl CARBAMATE INDUCED BEHAVIORAL CHAhGES IN BATS/ ABSTRACT *SL51t **1252 2044 PAGE 107-10* HARTUNG R RIGA! L R CORNISH H H ACUTE AND CHRONIC TOXICITY OF 01 IThANOLAMINE/ ABSTRACT CARSON 01 OXIDE NVOROCEN 01 SULFIDE INDUSTRY LIVER LIFIOi ANEMIA RESPIRATORY DIFFICULTY *7701044 *124219 PAGE 1O0 2007 MAUN C C EGAN G F MACEWEN J 0 VEtNOT E W 2090 ACUTE TOXICITY ANO FROPOSEO EMERGENCY EXPOSURE LINUS OF NITROGEN TRI FLUORIDE/ ABSTRACT HUNAN WORKERS HOUSE RAT OOG MONKEY A0CUT PROPELLANT NET HERO GLOtlN FORMATION DEATH *1701942 PAGE IOC FERIN J LUNG CLEARANCE OF T|TANIUN 01 OXIDE FARTIClCS IN RATS/ ABSTRACT INHALATION -1904*33 PAGE 10B 2BOB ULRICH C E ALARIC V MAOOOCR R N JENNINGS M J NEASURENENTS OF RISFIRATQRT SYSTEM PLOW RISISTAICE IN CYHOHOlGUS NONKfVS/ ABSTRACT MACACA-1RUS Alt BC*Nl MATERIAL REGRESSION ANALYSIS PAGE 109 2900 ALAR IE V ULRICH ( f MRURN A DAVIS C F (MCFARLAND H N EFFECTS OF LONG-TERM CONTINUOUS EXPOSURE TO SULFlA 0| OXIDE IN CYNOMOLGUS MONKEYS/ 2401 ABSTRACT PULMONARY SYSTEM NEGATIVE TOXICITY *7444099 PAGE 109 SWANN H i JR ULRICH C I MACFAMLUND H N ALARIC V 2902 EFFECTS OF LONG-tERN CONTINUOUS EXPOSURE TO SULPUR Dt 0X10* IN GUINfA-PICS/ ABSTRACT CARBON MOM OUDE UPTAKE SUAVIVAL PULMONARY FUNCTION NEGATIVE TOXICITY *7*44099 *4lOOB0 PACE 109-110 OUSEY W M SHANN H ( JR ALAR I( T WtSTQ PATHOLOGICAL EFFECTS OF LONG-TERM CONTINUOUS EXPOSURE ID SULFUR Ot OllOfi IN GUINEA-FIGS ANO CTNOMOLGUS MONRfTS/ ABSTRACT LUNG ALTERATIONS NICROSCOFY *7444095 PAGE 110 2001 TURK R F JAIN N C PHILLIPS R N FORNEY R R M4NN0 J ( PREPARATION ANO PRESERVATION OF DCLlA-4 TftRA HYDRO CANNABINOL/ ABSTRACT MARIHUANA CHROMATOGRAPHY NNR mass spectroscopy NITROGEN STORAGI FREEZING PHARMACOLOGY TOXICOLOGY PAGE SID-Ill 2404 MAHNO B R PORNEY R B MANNO J t RtLSHElNER G S RESPONSE OF THE ISOLATEO PERFUSED RAT HEART TO DELTA-9 TETRA HYDRO GANN4B1N0L/ ABSTRACT Human MARIHUANA SHORING TAChY cardia GAS GHOONATQGRAPHY PAGE 111 2909 PHILLIPS RN TURK R F FORNEY B % TOXICITY OF OtltA-9 TETRA HYDRO CANNABINOL IN BATS AND MICE/ abstract marihuana bChaviofrl observations Chromatography mhr MASS SPCClRDSCDPt |MlRA VENOUS iMTii PERITONEAL ORAL PAGE 111 2904 ROSlNBLUM 1 StRRQNC O H KILLEEN J C JR BIAOLlY J MILLS J H COOLS TON F AN EVALUATION OF tH( EFFECTS OF MONO SOOlUN GLUTAMATE |N MAN AND ANIMALS/ abstract rat rabbit mommy chicken soup *1*2472 PAGE 114 2907 GUESS W L CALlfV 0 J SOME PACTORS AFFECTING ImTRA CUTANEOUS tRAITATtOH TESTS IN RABAJIS/ 2904 absiract PACE 315 CKAMHE* m F 2909 EFFECT OF Dt PufHVL HTOAMIClM ON STORAGE OF DDT lM T-| RAT/ ABSTRACT RAT DILANTIN DOC LlVEX MlCROSOMAl *N|YMI ACTIVITY 97410 *72559 *502*1 page m GRAHAM s I HANSIM W H THE EFricrs OF SHORT-TERM ADMINISTRATION DP ETHYLSUREA UPON TNYROtO FUNCTION IN tHi RAT/ *10 OLI 4962 If ADDITIONAL BIBLIOGRAPHIC CITATIONS * cititions which are listed here are published without abstracts, since they are derived from BioResearch Index. 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INTI 0 ' NlSHRA A c '*tu) OF DI04SSAY IN THE DETERMINATION OF INSECTICIDE Tj*<*UfS/ C)QMU.4HtfLAN0CASrt OiFHHlA DDT RHC >902*) *A07Sl ,, 4M U-2), 24 i !i!c`81* hcmiti *7I A VQTO FREFICT UNtV NED 0 1)1. 1*71 9440 TOGORA H NflYA A MAXA1 K FURURAWA s tqmdi a iimuma j INOUE t OISHI S R0DAVA5MJ H A CASE OF TUMORS of tmc liver and sheen in CONJUNCTION NITh chronic alcoholism and oiadetcs/ ARS7RACT FIFADSIS CELL VACUOLIZATION *44179 FACE 1)1 TOXICOL AFFL FNARNACOL I* 12). !*U 9441 9441 944) 9444 9449 AL*N D S 9AFOROSCHE72 I ft CF9TC1N S % IQSYNTmCSII OF NfTftOSO FlFCRID)N( FROM NITRITE OR NITRATE ANO FIFfNIDINC IN ThI SMALL INtlSTlNE OF THE RAT/ AftSIRACT CARCINOGEN *9)17)) *147*7490 MOOTS* AGE )4*-l*9 OOUGHfRTY * J GOtOfAC L COULSfON F tH EFFECT OF CARftARU ON REFROOUCTION IN THE DNRCV NACACA-MULATTA/ AftStNACT IIRATOCCNtSlS *4)292 FACE >49 SANTOLUCITO J A NASSAN A MMITCONft f R OftSVRVATIOTtS ON The ALTERATION RY CAR*ARYL OF 4*J0TN NUSCLC FMRARATION RESFONSCS TQ N0REF|N|FmRINE/ ARS7RACT RAT RAftfttT AOREN(RGIC RfCCFTORS UTERUS INTESTINE *4)292 FACE >49 CHIN i -H SULLIVAN L J COMPARATIVE MF7AR0LIC FROM|LIS OF CARtARYL 9V RIONCT LIVER NO LUNG OF fM| 004 ANO RAT USING AN ORGAN MAINTCMANCE TECHNIQUE/ AllTRACT *4)251 FACE 949*944 LOCEC R R ftARON R L THE NETAROtISM OF CARftARYL I NAAMThYL*HHIETnVL CARft ANA Tf IT FOftACCO-D CELLS IN SUSFCNSION CULTURE/ STRICT *4)292 9444 NURFHY S 0 CHfEVfR I l iNNIfttriON OF RAT TISSUE CARftOXU ESTERASES AND ChQLIN ESTERASE ft? AftATf 0000 TCTAA M|TmtL-0 O-THIO0l-4-FH(N7LCNE FHOSFhOROTHIOATE/ AOSTAACT FCSTICIOC *44197 FACE 144-947 9447 NOOAR A 44*LET l UtlNTRAUft S tfavinOha n I THE EFFECTS OF CMIONK OISULFQTON TREATMENT ON TN| CHOLtN ESTERASE ACTIVITY OF THE RAT/ ABSTRACT *2*104* FACE >47 9441 RAM* SASfRV 4 V EULFHVORH GROUPS IN THE VICINITY QF MAMMALIAN CHOLINERGIC MtfFTDRS ANO THEIR INFLICAttON IN THE TOXICITY OF NMCUA1ALS/ AASTRACT RAT NtURQ MUSCULAR TRANSMISSION >74R*9 FACE >44 944* SHERMAN M THf TOXICITY OF SIDURON A SUftSttTUTEO UREA NtRftlCIOE/ AtSTRACT RAT OOC FESTICIDC >*279 FACE 14* 9474 laham s NETaAOLISM OF A MEN CARCINOGEN RELATED TO 4EN2IDINE/ AftSTRACT RAT ) NltMQXV ftCNZIDINt *942)9 FACE )>-)** 9471 RHERA R S HUSTON ft L NCRlNtfT U F R| NATAL ANO FOST NATAL STUDIES ON 2 4 9 7*1 CmLQROFNEnOxV ACETIC-ACID 2 *D ANO OIRlVATlVf) |M NlSTAR *AT$/ AASIRACT FC)fICIHCS >*A797 **1749 fact )a*-wo 9472 RfNNCOV C CAL AMD*A J C ARNOLD 0 RfFLlNCIR N L MUTAGENIC AND TERATOGENIC StUOlES HiIH LEAD ACETATE AND TltRA EIHVi LI AD/ 'ARSTRACI MOUSE * 1*002 >1*41*9 FACE )7D 947) NCCAATHV J F FANCHTR O E KfMMfOV C L RCFLIMCIR M L CAL*N0*4 J C RCFRODUCTION ANO TERATOLOGY STUDIES WITH THE INSECTICIDE ' CARAO/URAN/ ARSTRACT OOC RAT RA**|T >97**1 FACE >70 9474 LOEHR R F COX G I CARSON S REINER S M YOG IN f | MUTAGENIC STUDIES tf|TH ft M|NO NICOTINAMIDE IN RAT)/ ARSTRACt >7**)I face sti 9A79 SIMGH A > LAwRVNlC H AUTI4N J IIRATOGtNltiTV QF A GROUP 0/ *wTHAI Alt ISIt>S |N At S/ V AtSTRACT FOi* VINYL LHL0*101 FLASTlCltER MWJOJ FACE >72 947* NIfAC G S TRiNfRTLM H l SAMSON J R COLOUELL ft EFFECTS OF ftARBITURATES ON ETHANOL ELIMINATION IN THE RAT/ AftSTRACT *4*t 79 FACE 97) 9*77 COiDWELL ft 4 TRENtRILM H L THOMAS 4 H NlfttRG C S EFFECT OF ETHANOL ON Th( OISTRItUTION OF FHfNO GRRIITal AMO FfNIO RAMRITAL IN THf R*r/ STRACT *4*1M >747** *90044 OLI 4963 o?s OH ' on Mil SOM i J Jl twiomnaimi M phtnyi ARina/nti mum ooimimis rv mooiir CM*M AND PINK MUM ARMUOft-l/S* PI NA| U4-0UMRARUW FINAIUS-V 1 If IPUS Pf NATUS-Anf CVS HCAIO PANCftlAS OCA'HtMAK UC*'*UCH 410* ACE 90- muspn ft j VrnG 0 T c eoro a harms r m ft LUNG EDEMA FACTOR FAQ* MOULDY WttT-01fttQE&-0 IPOMOCA-BATATAS-O/ NOtC NOUS* HUMAN A IPOMfANOL fUSAMUH-JAYANICUM PACE 4z-si STONE 0 NATALKA t PWlftSRI I 00 miMCIH SMCftENERS INGESTED IN PREGNANCY A^FfC! THE Of ASM INC/ NOTE HUNAN NAT CVCIANATE BRAIN DAMAGE MENTAL RETARDATION GOWNS SYNDROME PHYSICAL ANOMALT BEHAVIORAL MOSLEMS *100M0 MCE 51 NAQORHl SNA CASIO* J E MECHANISM OF INSECTICIDE IhOUCEO DIURESIS IN RHOONIuS-PROL HUS/ NOTE DOT fttOMN OICROTOPHOS I EC TO AN *HCTHft|N NICOTINE LINDANE MftLftlOhliN TUBULES NfNQlVNPM PARALYSIS OESICCATIOn DIURETIC HOftNDNE n$OTmO*ACIC GANGLION `IMIS *miB* *50201 *300002 MIIOIBIZO 5M1f *J7J57B2 AGE 05-90 ********************************** 01 EV RADIOL NuCL NEO 7T7Q I99002-41 1*70 `OTA OtELCCtt * IWASlRtfMltl A JORDAN A KUNlCAI ft 2YCMUNTQMIC2 Z " THf CINE ROfNTCENOGftAftHlt PICTURE OF SWALLOWING AFtCft CHEMICAL BUNNS OF THE tSOPNRGU*/ HUMAN ANTIBIOTIC CQftTtCOID AGE 707-TOO UMSCN MISS TECH TL III, INTV 007B BALK H AMSEtTlCtOf SYNERGISTS/ ..^IMRONYL BUTOflOE METABOLISM degradation -MOJO RACE 11 InSECTICIOC TOXtCtTV INHIBITION MlIN-MlSSENSCHAFT 10 10-101, INTI >*** ************0***a**i BOBO UNREAL* E RE*Nf I MAI BEL A OITCftHlNATlON OF RESIDUES OF EFFECTIVE MATERIAL ANQ STUDY OF THE FiOMtNtINC BEHAVIOR AFTER USf OF BOTAYTlCIDES IN VINICULTURE/ &AaPE-0 AUICE BOTftVm-tlNtREA ACE 707-MI MO A mo 490000*11. 1B70*|RT| **,t .o M rei.cOLMT w HUAGNAEN A1M7-A2N9ITA*MUSCARIA MOUSE. ***#*************** DULL N T ACAO HID 07 tlOU 1071 *****.*********** 012 GAHGAROSA E J The EPIDEMIOLOGY of CHOLERA fast and MISENT/ VACCINE CONTAMINATED hater FOOD HISTORY GAGE 1100-1191 *************************************< ARH Hie RAD rOKSUOL 10 ISUFFL 01, 1040 4B1 4010 4D9 40*4 OAT 40BB TRIFCA WORK IVECAN YUGOSLAV AISOCtAY|Ht ON <KtU4T tDNAL HCAlfH International symposium oh lead poisoning ivican votwhiawia July ii-io ioab ?*am/ FAGF 1-177 SfANROVIC M ftrpvic t CONfFCL OF LIAO IN PREVENTION 0* LEAD *OLA 11 o The AIR SIGNIFICANCE POISONING/ STATIC ft F0 E>QSURC *0 AND MORrMS *T*t51 page |-e RING I RftftMITFRS OF LEAD R*SOFT|ON/ INDUSTRY *Y*B91 AGE *-12 FQMLEA D C CtNTAOl 0/ INCUSTftflt fFCSUE TO LEAD IN f"f US* 055l/ Art n-i* * At jFC1. * A An ASSISSWVNf Of fMf VJIUI Cf lA*'5*ir''*Y |NY: I|CATI*N IN tnt DEftCMCH AND tlNTtlt o* HAD POISONING/ WORRfft CD*PO PORPHYRIN t<sf *7**41 PACE 10-2/ tiMfi I *HRT|DNtH|PS BETkEEN IhC CONCENTRATIONS OF Ll*0 IN 9LQO0 ANO DELTA AMINO LEVULK*ACID |N URINE OURING LEAD EXPOSED HO*X A' |V4 l . 0DR9 4000 0001 0007 0091 0000 0009 0000 0007 000* " GOO BIDO 0101 *102 * TAANI/ PA/,f /t-ID SKIFFS A J AMINO LIVUllNtC-AClO IN INC EVALUATION OF LEAP (lOOSUftf/ WORKERS *T*B9l FACE SI-SS OE SftUlN A EFFECT OF LEAD EXPOSURE ON THE LEVEL OF DELTA ANIN0 LEVULlNIC oehtooatase activity/ MOIftfftS PORPHYRINS *7B5I FACE 19-02 HOLMOVIST I LOOO LEAO DETERMINATIONS in CONTROL of EXPOSED MOANERS *9*091/ FACE 01-07 WILLIAMS M R ft METHOD FOR ESTIMATING THf COMPARATIVE MERITS OF THE BIOLOGICAL TESTS OF LEAD EXPOSURE *70*91/ age ao*m OftFIC-MAJ 1C 0 BfftlTlC t VlDiLJA B EftSAHC E RELATIONSHIP BlIMEtM LEAO IN THE BONE MARROW AHO LBaD IN THl BLOOD/ NORftEIS *70151 FAGE 59-5? SfANROVIC N FETftOvIC L FQLETI 0 ASSESSMENT OF TM| value and interrelations of bio TOXICOLOGICAL ANALVS I* OF URINE IN HORROR* Min CHRONIC LEAO EXPOSURE *70*91/ AGE *90-00 SCMLEGfL M RACTICAL VALUE OF OtFFfftfNT SCREENING TESTS IN THE CONTROL OF GNfOT NUMBERS OF MOORMEN WITH !*FQlU*f TO LEAD IN THE AUTOMOBILE MANUFACTURE *ToS9l/ AGE 07-70 NOmajENrOVA a CAROtO VASCULAR SYSTEM IN LEAD POISONING/ HUNAN *70*91 AGE 71-79 GRAOVAC-LIAOSAVIC l DOOIC S ACCIDENTAL LEAO OOtSQNING IN A FAMILY/ CHILDREN ADULTS LEAD BULLETS *7**41 AGE 77*12 NARKICEVIC R EERtftC T ON THE HEFATO TOXIC ACTION OF LEAO/ HUNAN *70191 net *1-93 RAOONIC N fUFANIC V SARK N NISTOLDCtCAL CHANGES OF ThE SIDNEYS IN LIAO AOISONlNG/ HUNAN *70191 AGE Of-OB * IC*MAJJC0 SARK N VURDEIJA fi BCNI7IC T MARRICEVIC R ESAnC a OUR EXNCRICNCC WUH THE TREATMENT OF IE*0 POISONING WITH CHELATES/ HUMAN IOTA COMFLEXONl AnT(OOT-ORuC *70191 *00021 AGE 00*111 VASlL/fVlC S nacic-filifdvic 0 ANOELQVSRI A EXPERIENCES IN ORAL ANO FARENTERAL AftFilCATlON OF CALCIUM 01 SODIUM EOT A/ TRJMAN ANTIOOtC-ORuG INDUSTRIAL HAZARDS *B)*00 AGE 111*121 DORIC 0 MILK S BOJOVIC V GRAQVAC-LEPQSAvK L URINARV EXCRETION OF 2 INC IN MORRCBS EXFOSED TO LIAO TREATEO N|Th CALCIUM 01 SOOlUM COTA/ AMTtOQTI-OftUG >T0B91 *74*0444 *1200729# FACE 129*127 MM*H*M**lnl*l(*lt*****M*f****f*****a***l**|ittt ` ' " *' "* c * .............. *.*.**.M.I.*.i*i..**..****#*****-***** AIDS BftICORD J CABAN! N NAOELAINf fi VIOLA 0 FORMATION OF FHOTOtVTlt FARTICLES IN THE AIR/ At* FOLLUTION FAGC 7BT-7O0 *********> LANCET 7 174401 * 1070 4100 4104 .4104 LOT LOGAN R F L 0RAN6E PALMS IN LANCASHIRE/ LETTER ENGLAND HOUSEWIVIS RAW CAftROtS-D EXCESS CAAOUNf Sn|AT GLAND EXCRETION PAGE 191 JAttlft R J FUNIN M J coniaminaiion fF Rinno sioftco in piastic faCrs/ H fII* RAf 01 OCtVl Pm|mat A f E PL ASt K|It ft POLY VINYL ClO*IO( TUBING FMYOo/AA/ ||l**u PAGE 141 HOWELL A SitOXING HABITS ANQ LABOAATOftT TESTS/ ifltlR HUMAN PACE 192 Wtlli H A ATHESNARf RIfE/ LFTTYR human CROTAIUS-40AMANTEUS I*OMAIN-LlRt EFFECT AGF 1)4 / ANN If.tMN **"5 M (*i . l*M 101 LIChTEmStEIN L HUMAN <<iMENlltlON BY INDUSTRY THE CASE OF EM/r*< OETERGfNtS/ editorial roiieoiooY AGE OB4-OA9 OLl 4964 457 (July. 1972) fell CMVltirs, >>[ th* fnillrlr (|t|Hirlliiin aivl (lrrriasr In the number of follicle evils. When vitamin E was given to these mice together with Cd water- these regressive changes were inhibited some* what.--K. P. 6216. NIEHIZUMI, M. Electron microscopic charges following administration of heavy mrtnK_, JAP J CLIN 1'ATJIOL 19(1): 42-45 "* 1971,-*Rats were given drinking water containing CdCl2 for 2 vk-12 mo. The following tubule cell changes were observed electron-microscopic* ally: increased microbodlcs, changes in the mitochondria, and increased lysozymes. When rats were given water containing PblCHjCOO)?. similar changes occurred. When HgCl2 (30 mgAg) was injected sub* cutaneousiy into rats, mitochondrial cristae became like cellules. Mitochondrial destruction was also observed ,--K. P. 6217. MATSUMOTO, H. Metabolism and determination of lead in lead poisoning. JAP J CUN PATHOL 19(1): 56-6271971--Urinary jJ coprophyrui should be qualitatively as well as quantitatively determined 0 to detect Pb poisoning in humans. Urinary Pb level (over 35 ug/L) and blood Pb level (over 17 ^g/100 ml) should be used to supplement the coprophyrln level test. Persons exposed to occupational, medicinal and other sources of Pb showed higher levels of Pb in the urine (150 pg^L) and blood (60 pg/100 ml).--K. P. 6218. HOTTA, S. and 5. OSAJIMA. Chronic cadmium poisoning. M JAP J CLIN PATHOL 18(1); 46-50. 1971.--Studies on renal tubular malfunctions in humans caused by Cd poisoning are reviewed,--K. P. 6219. HUBER, G. L. and F. M. LA FORCE- Comparative effects of osone and oxygen on pulmonary antibacterial defense mechanisms. A ANTDUCROB AGENTS CHEMOTHER 10. iM-T3i7l970.--To " ! B determine the effect of 2 environmentally and therapeutically important Q oxidants, Oj and Oj{, on pulmonary defense mechanisms, bacterial clearance was evaluated by quantifying bacterial inactivation in the hugs of 2500 mice after exposure to an aerosol of radiolabeled (32?) Staphylococcus aureus. Controls Inactivated 92 27 of inhaled bacteria. <5j administraUon resulted in diminished clearance directly related to the level d( oxidant exposure: 85 a 27 inactivated after exposure to 0.1 ppm of O3 for 3 hr, 72 *47 at 0.5 ppm. and 45 77 at 1.0 ppm. After prolonged exposure to 1007 02. clearance diminished in direct relation to duration of exposure; 87 a 27 Inactivated after 12 hr, 79 a 2% at 24 hr, 69 a 3% at 48 hr, and 56 a 6% at 72 hr of exposure. TTiere was a similar dose-response depression of clearance at lower O2 con centrations. Electron microscopy slvelor macrophages harvested from the lungs of mice exposed to both oxidants revealed in progressively increasing numbers ultmatruetyral alterations characteristic of cellular Injury. These studies incite a progressive, dose-related functional depression in lntrapulmftary antibacterial defenses and structural alterations in alveolar macrophages after exposure to an Important and frequently used therapeutic agent, O2. and a similar dose-related depression In bacterial clearance and altered macrophage structure after exposure to a common air pollutant, O3. at levels frequently found M our environment.--S. R. P, 6220. LENOIR, L. F., P. H. MULLER and G. M LENOIR. Biological mroach to the acute alcoholic state. LILLE MED 16(5): 715-7617" 1.--Studies of blocd alcohol levels of multiple subieeta, as shown by routine testa at the time of various legal infractions, in correlation with ellnlcai symptoms showed the importance of such tests in earlier detec tion of latent alcoholic conditions. Such tests can sometimes explain a certain number of psychoaffective disturbances, states of instability, clumsiness, highway accidents or accidents at work, and the intffec* fiveoess of ftrtain treatments. Although alcohol effects were propor tional to blodd aleahol levels, this progression was neither absolute nor constant, being especially subject to change after the age of 25. The study also revealed an exceptionally high tendency of subjects with a high blood alcohol level in 1 lest to have high levels in subsequent tests. With reference to the highways, the number of drivers driving with a high blood alcohol level was found to be considerable; of 207 of the drivers who were subjected to systematic testa. 207 presented aacesstve levels.--8. L. R. 8321. 8ANZ SANCHEZ. F. Mvcotoxlns and their publie health R AN R ACAD NACLMED (MADR) 88(2); 311-552. p 1971.--The literature on myeotoxlns is reviewed. These poisons are y generated by many types of fungi, which sometimes are known to have 2 developed on poorly stored foods or feeds, e.g.. cereals. In Isolated 2 esses they have caused poisoning symptoms jin animals and man. The host known outbreak occurred In turkeys, in England, due to groundnut meal contaminated with an aflaioxln produced by ArpergilUn flavus. Numerous cases of human disease In Japan were traced to "yellow rice," In which the mycotte metabolite was produced by various species Ct PorlrtVittn snd V 'rIn screening the .-r-i.iboUt-9 zr. fv* tensive senes of nioiav (or possibly useful antioiotics, a Ur^e variety of molds were founJ to generate metabolites poisonous to laboratory animals. The chemical structure of these mycotaxmo ani the fur.cn that generate them are systematically reviewed. It Is thought that some ct these poisons might be harmful to man, posaibly contributing to cancer, hence discouragement of the distribution of mold-contaminated foods Is recommended-,,,-P- H- V. 1. n 6216*6228 6722. nnuciiinrn. a., a. cavatohia, a. dal canton, i. FRANCHINI. T. M. NERI and A. NOVARIN1. Formulation of biological indexes for eridcmiolorical studies of exposure 10 lead poisoning. 6~ CLIN MED 52(3): 234-246. 1971.--Biological exposure indices for the risk of Pb intoxication were derived by determining the concentration of delta-aminolevulinic acid and coproporphyrin, and by analyzing the lead creatinine level, urine osmularlty, and diuretic volume.R. P, M 6223. TEICHMANN, W. GIBEL. T. SCHRAMM and K. LOHS. Preventive medicine recommendation for work with chemical carclnosens. ARCH CiE&HWULSTFOKSCH 37(4): 313-326. 1971.--Legal winrs* concerning tiic protection o( employee* from exposure to carcinogen* and the danger! which may remit [orm working with chemical carcinogens are discussed. A series of important groups of substances containing carcinogenic compounds are chemically char acterised and their mode of action la studied. Protective measures art proposed for all types of handling (e,g., production, measurement, biological teating preservation, transport, destruction) of these carcino gens. Demands mad* upon laboratories and clothing, the qualification of employees, medical supervision of endangered persons and instruc tions on possible endangers of working with carcinogenic substances are also presented.--S. R. P. ^ O * h o b nw <224. GIBEL, W,, K. LOHS. G. P. WILDNER and D. ZIEBARTH. Animal experiment* studies on hepatntoale and eaneerotrcnlc actlvltv of organoohotphonis compounds: T. Trichlorphon. ARCH GESCH- tyOLStFokSCH 11^l.--Long-term suidist of rats snd mice given trichlonihan revealed sever* Uver damage associated with heavy steatosis, necrosis and cirrhosis formation. Liver tumor* were observed in 2 cases. In addition, n number of papillomas formed In the forestomach and a local sarcoma was found.--S. R. P. <225. SCHIECHE, U,, M. KESSLER and S. KOBER. Data on stekneas in a hiaat furnace steel plant. 2 AERZTL FORTBILD (JENA) <4(121: <17-<2l. l4Vd.--bersonnel directly engaged in blast furnace operattnis (in Germany), despite their exposure to occupational hacards of best, bums and noxious gases, had a belter record of freedom from illness and accident! than other personnel from Uie same enterprise. This is because blast furnace operator* *rt selected mainly from the 25-39 age group, are predominantly well trained men, work under good discipline snd organization, and have a high sense of personal responsibility; in iddltion. their work is surrounded by special safety precaution*. CO poisoning ease* have steadily declined, and there ha* been no fatal case since 1955. illness in til department* tended to Increase in spring and to decline in summer. Colde snd accidents claimed the larger number of case* of disability, followed by digestive disorders. However, periods of disability were longest for cardiovascular and respiratory diieaaes and reproductive disorders. Disability cases mounted In the higher age groups.--P. H. V. I. > 222<. GROSSER, P- J. Studies on parallel child groups with consider ation of atr hygiene aspects, Z AERZTL FORTBILD (JENA) 64(9): 463-4M, lSYa--Fietor* involved in using parallel groups of children to study air pollutant effects on the general population art discussed. A study using 140 children was employed a* an example. Children are highly euited for these tests because other fsetors (smoking, occupa tional stress, general living conditions) have not influenced them to a great extent, in these studies children ire from basically similar socio-economic backgrounds. Parallel groups are baaed on age, sex, number of sibling,, individuals/room index and number of consumer goods owned by the family. Immission values for the areas studied must be known for all toxic substances studisd and for comparative purposes th* area* studied must show wide differences in these values. Characteristics studied include height, weight, blood pressure, whit* blood count, red blood count, erythi'ogram, total protein, alkaline phos phatase in serum snd serum properdin, level, vital capacity and X-ray of th* toft wnst. Results of th* study mentioned are presented else where.--S.K. J. xe>> 6227. MUSCHTER. W. snd P. SMOLtNKA. Studies on the aspiration concentration of duel and sulfur dioxide at different height* in the city cfntjr bj Berlin, Z AERZTL FOHTDILP (JENA) 64(9): 467-471. 1970.--Studies of SO2 And total lmmlsslon particle (car. home and factory exhausts) concentrations at 4, 40 and 75 m were made In Berlin, In both cases concentrations were lower at the higher levels. Differences were significant between the tat and 2nd and 1st and 3rd levels and In significant between the 2nd and 3rd levels. Meterologieal (actors (wind speed and temperature) which effect these concent rations at the various heights were discussed. With decreasing wind speed there is an in crease of the concentrations at higher levels. This is also true of CO. --8. K. J. Ho ZENK, H Occupational vestibular damsys. Z AERZTL FOlliLilD iJLNA) v4Uj7; 676-biS. 1 j0.--Lshptoses of vestioular nerve reactions to industrial poisons by means of combined calorie, rotational and positional tests, art the measurement of nystagmus are presented. TTit vestibular nerve ties in with the nystagmogenlc zone in the brain stem, where peripheral stimuli art transformed into oculomotor Impulses. The resulting nystagmus may be the only ob jective method for confirming the dizziness of which the patient OLI 4965 622^-624 0 ce*npUlns. Among the noxious arenas prutofinc central li-Mon* arc Cd, Hg, V )r>1 cyanides. narcotic h:ili>i'i>n;UiHl .irhons (|n)yvmvl Chloride. irlcMorethylrm :wd dicMororth.mct, niUo.unt ,iiiiiM<Hiim- pounds like nitrobenzene and aniline, and trl-o-erc.iyl pho.spti.ilo. -- P. It. V. I. 6229. nZUML O. and Y, MORI. Histopatholoifieal study of the nasal q and paranasal sinuses of germ-free gumpa purs exposed to sottur diomii.TsO;). J OTOLARYNGOL JAP ~P(M: IiSi-lig. 1^1.-- The nasal cavity had pu* containing neutrophile*. exfoliation of the epithelium, infiltration of the epithelium by neutrophils and acute inflammation of the nasal cavity following exposure to SO2 --K. p. 6220. TAKEMURA, N. Tumor of the bladder as cancer caused by 2 environmental factors. ACTA L'RqL jap 17(3^55*156. 1971.-^ Carcinogenic properties of 2-naphthylamine. 4,4'-diaininodiphenylmethane, and chlornaphasln in human and animal urinary bladders are discussed.--K. P. 6231. GENMAN. L. Acute intoxications. DUODECIM 67(91: 2 705-706. 1971.--in 1967, according to official Finnish statistics'. 621 persons died of different kinds of intoxications. The majority of deaths were due to suicide and alcohol intoxications, in 1969 the Department of F6renic Medicine, at Helsinki University, recorded 264 intoxications, of which 166 were due to alcohol. The number of actual accidental in* tosdcaUons is relatively small. Mortality in acute intoxications'is presently about 1Sr. In suicide attempts, several kinds of drugs or agents generally are used; pure intoxications by I substance are rather unusual. In Finland, more than 1000 persons die/yr by their own hand. A better awareness of the problems connected with acute intoxications, and ways to cope with them, are advocated.--M. D. S. 6232. JOUGLARD. J. and V. VINCENT. Pulmonary sims of tmtes2 tions of solvents. MARS MED 106(10)*. 696-691" 1971,--Statistics ol the Poison Control Centers of Marseille and Lyon (France) showed that of 3276 poisoning cases treated from Jan. to July 1970. 3.67 (or 2-2 Ahes/wk) were due to solvent ingestion. Of the solvents involved, petroleum and petroleum products were the most common followed by chlorinated solvents, acetone and nail polish remover*, oil of tereben* thine, cresyL, and ether. Study of the pulmonary symptomatologies showed the onset of pulmonary disorders to be more common In children (41% of the cases excluding 43 doubtful poisonings) than in sdults (137 ). Of 46 children with actual symptoms of solvent poisoning. 11 presented coughs with sibllance. 5 dyspnea with cyanosis, and 3 true pneumo pathies. In 6 adults (total of 39) presenting pulmonary symptoms, these symptoms consisted of coughing and laryngeal irritation (3 cases), pulmonary congestion (1 ease), and cyanosis during coma (1 case). A worsening of these pulmonary symptoms after solvent ingestion was often concomitant with methods of digestive elimination * gastric lavage and induced vomiting. At the Marseille center, a 167 rate of digestive elimination maneuvers was noted in solvent ingestion cases, and 1/2 of these patients presented considerable pulmonary symptoms. When di gestive elimination la necessary, gastric lavage should be practiced after tracheal intubation. Potential danger wat noted in the (set that such solvents may be used as excipients as well as principle ingre dients. When poisoning occurs due to the principle ingredient, the solvent excipient may cause complications. In addition, the use of Such solvents as excipients is not always known, due to manufacturers' secrecy regarding product composition.--$. L. R. 6233. JOUGLARD. J., G. FAGOT. B. DEGUIGNE and J. A. ARLAUO. 2 cr}^Y??-C pfj,on^c and U emergency treatment. MARS MED 108(9); 571-575. 19^1.--Acute hydrocyanic poisoning is rare as is " Shown by statistics from the Marseille Poison Control Center: 18 cases during a 3 1/2 yr period. Following a review of the circumstances of poisoning, which vary according to whether hydrocyanic acid, cyanate derivatives, or eyanogtneuc glucosidt* are involved, the metabolism Of the toxin and its physiopathoiogy were discussed. Once it had been Inhaled or Ingested and has diffused Into the tissues penetrating the cells, eyanide determines histotoxic anoxia by blocking cytochrome oxidase a3. Aside from tuprs-scute poisoning in which death is almost immediate, the symptomatology of this intoxication may present 3 phases, as in acute poisoning, or s simple dyspnea with headaches, vertigo, and vomiting in the more common subacute form. Since the blocking of cytochrome oxidase is reversible, any substance with a great affinity for cyanide will tend to release the ferric Iron of cyto chrome oxidase and will again allow cellular respiration. Such anti dotes are sodium thiosulfate, methcmoglobintzing scent*, eobaltic chelating agents, and hydroxocobalamino. The lust agent with its rapid action and total harmlessness in the ideal treatment fur acute hydro cyanic poisoning. Emergency treatment in the absence of a physician was also discussed.--S. L. R. 6234. SZYMANKlFwlCZ. S ( * rmiczl and tin rrr.ii r1 u. ^ 0 according to reports r^irinv iV 1 "07-1365 KLINOCZNA T iid): S53-55i.197l.-Th.' retell* oi 10 yr eumcal research 0/ eye 2 injuries occurring at an industrial renur are reported. The ftHe of the accident, kind of burn, age and *rv <>1 patient* and degree of burn art discussed.--C. M. M. [VOI, 1 No. 7) 496 6235. DENIM, F., V. COIAMU5SI, G. SIV1ERI and G. CEHVI, EvaluaiPvt #f (lie anll-pidlutin^ synirm (nr waters used in the prtrol eheniiraljhiJuMnr `AKL'ISI' ST ANNA-f KitJtAIU 2J757$J: lf1*727. (frO.-tV vapor* formed over decantation tanks containing petrtferous product* were determined and compared with the vapors from an experi mental tank without decantation and therefore without any purificationA marked difference In values was found. The vapors over the decants* tion tanks were within the maximum acceptable concentration standard. The vapors from the other tanks exceeded this limit. The efficacy of anti-pollution purification treatment by this method was taut demon strated.-*C. M. M. yy 6236. DENtNI, F,, V. COLAMUSSI, G. SIVIERI and G. CERVi. Environmental concentration and atmospheric spread of alkyl lead during procedures of ethylation and methvlatlnn of gasoline. ARC1SP ST ANNA FERRARA 23(4/5): 385-409. 187Q.-ThV presence Of alkyl Pb was determined in petrol ethylation plants above and around wagons discharging ethyl fluid and in the atmosphere both close to and far from the plant. A considerable part of organic Pb vapora are absorbed and conveyed by cooling wares. In the petrol ethylation process Use!/ there is little leakage and in petrol blends there is none. Pb coneen* trauons of up to 1.4 x 10 in5 are formed in the external atmosphere when there is heavy humidity. The organic Pb compound can be found even as far as 70 m from the source. On dry sunny days there is no dispersion in the atmosphere, as the poison quickly disappears (tri ethyl Pb probably turns into crystalline compounds).--C. M. M. A G M 6237. CABRERA. H. N., J. J. AVILA six) O. B1ANCHI. Actinic Ueben. ARCH ARGENT DERMATOL 2<Xr/2): 45-52. 1970.--Three cases are presented and the literature is reviewed. Actinic lichen is a derma tosis of photoexpoeed areas, whieh appears after eimoture to the sun. It is represented by brownish pigmented plaques with raised edges sad ring-shaped configuration and by pigmented or hypochromic, flat, small, isolated papules. This disorder must be included within the atypical forms of Uchen planus.--C. M. M, y 6238. HAYES, W, J. Jr. The litaOcuouanes* of DDT for humans demonstrated to the control oi malaria" BOL OF SANJT PANAM 71(6): 481-499. 1971.--Despite the prolonged etmosure of the world population to DDT. the only confirmed cases of poisoning were the result of massive accidental or suicidal ingestion. The effects of 1 or more massive doses of DDT by oral, dermal, or respiratory routes was studied. The results agree with reports of accidents involving DDT, and indicate that 10 mg/kg is a threshold dose, cauetng moderate illness in some and no symptoms In others. The safety of DDT for man is based not on human immunity to the compound but on the ability to restrict its intake to low levels. It is impossible to determine at this time whether the dosages reported to be carcinogenic in mice would also be so in human beings. Tests in mice to determine whether DDT produces dominant lethal mutations proved negative, while unpublished testa in rats are said to have been positive; thus, any attempt to suggest that DDT is a mutagen in man is premature. In relation to enzyme in duction. an increase in microsomal enzymes was demonstrated in people with occupational exposure to a variety of pesticides or Jo DDT alone, yet the liver enzyme activity of workers heavily exposed to DDT was essentially normal. The danger of DDT is to wildlife and not to man. Some countries can restrict its use. but others cannot posaibly do so until adequate substitutes become available. Indoor spraying of DDT, as practiced (or malaria control, produces little contamination and poses an insignificant threat to any species and no threat to the inhabi tants of sprayed house*.--S. R. P. P 2 6239. GAFTURL E. and F, BRUGNONE, Respiratory pathology caused by isocyanates in varnlshera. MED LAV 62(2/3)7 151-1&7, 0 1971,--TNventyVamishers who presented or complained of symptoms E of bronchial asthma or persistent asthmatic bronchitis following the use of polyurethamc lacquers were examined. Sensitization to iso cyanates was checked by performing tntracutaneoue tests with a con jugate of toluene diisocymnate with human serum albumin. TTie occurrence of the symptoms following both cessation of work and new laquer contact were observed. Inhalation tests with the conjugate and with acetyl choline were Cltried out. On the basis of clinical observations and symptoms, it was concluded that some of the vamishers presented signs of sensitization; the skin snd inhalation tests used to show the presence of reagents were doubtful or negative. Some vamishers pre sented a chronic bronchitis as a consequence of the irritative action of isocyanates.--S. R. P. 6240. GHEZZI. l,, P. MARANZANA and D. ZANNTNt. On asbcetosia In Piedmont. Liguria and Lombardy MED LAV 63(2/3^ 121-119. 1971.--Since 1MJ. when the compulsory insurance against asbestosis wa* started in Italy, 1530 workers were compensated for aabesto* pneumocomoai* in Piedmont and in the provinces of Milan. Bergamo ami `a1, ->' lifse, lkC5 were sull living un March 31. 1970. Aube*toft-s of mMerate or advanced degree constituted 32*7 of the cases (this percentage was higher than 50. if only the workers who were employed in the textile industry and in dock-yards are considered). Pleural changes, both calcific and not. were radlologically demonstrated in 527 of asbestotic subjects who had worked in textile mills; among the Q x 2 OLI 4966 6229-024 0 complain*. Among thf noxious scents producing central lesions arc Cd, jig, V and cyanides, narcuhr halogenated hyfWorrlmn? (ji.l>vinyl dilorulo. IfUiilnrctltylrtw anil (lit'MDroa'th.mr). mho aiwl .hhimh nmipourols like niLrobifUrnf and auillm1, and tri-w-errayl plM>s|ihate. **l. II. V, I. 6229. nzUMI. 0- and Y. MORI. Htstopatholocical study of the nasal q tnd paranasal slnu*cs of ft* rfn-frnn guinea purs oinked n> sullur dioxide (SQgV..IrOTOiARYNGOL JAP 74(9): I3S8^T5G2. 1971.-The nasal cavity had pus containing ncutrophile*. exfoliation of the epithelium, infiltration of the epithelium by neutrophils and acute inflamination of the nasal cavity following exposure to SO2.--K. P, 6230. TAJCEMUTIA, N. Tumor of the bladder as cancer caused by Z environmental factors, ACTA UROL JAP 17(3): 155-156. 1971.-- tircinofcnic properties of 3-naphthylamine, 4,4`-diaminodiphenyl* methane, and chiornaphaain in human and animal urinary bladders are discussed.--K. P. 6231. CXNMAK. L. Acute intoxications. DUODEOM 87(9); z 706*706.1971 .**ln 1967. according to official Finnish statistics. 621 persons died of different kinds of intoxications. The majority of deaths were due to suicide and alcohol intoxications. In 1969 the Department of Firensii; Medicine, at Helsinki University, recorded 364 intoxications, of whleh 166 were due to alcohol. The number of actual accidental in toxications is relatively small. Mortality in acute intoxications ta presently about 1$. In suicide attempts, several kinds of drugs or agents generally are used; pure intoxications by 1 substance are rather unusual. In Finland, more than 1000 persona die/yr by their own hand. A better awareness of the problems connected with acute intoxications, and ways to cope with them, are advocated.--M. D. S. 6232. JOVGLARD, J. and V. VINCENT. Pulmonary sign* of ingeaZ tlons of solvents. MARS MED 106fl0): 696-6&1. 1971,Statistics of the Poison Control Centers of Marseille and Lyon (France) showed that of 3275 poisoning cases treated from Jan. to July 1970. 3.6^ (or 2-3 cases/wk) were due to solvent Ingestion. Of the solvents Involved, petroleum and petroleum products were the most common followed by chlorinated solvents, acetone and nail polish removers, oil of terebenthine, cresyU and ether. Study of the pulmonary symptomatologies showed the onset of pulmonary disorders to be more common in children (41% of the cases excluding 43 doubtful poisonings) than in adults (137). Of 46 children with actual symptoms of solvent poisoning. 11 presented coughs with sibilance. S dyspnea with cyanosii. and 3 true pneumo pathies. In 5 adults (total of 39) presenting pulmonary symptoms, these symptoms consisted of coughing and laryngeal Irritation (3 cases), pulmonary congestion (1 case), and cyanosis during coma (1 case), A worsening of these pulmonary symptoms after solvent ingestion was often concomitant with methods of digestive elimination - gastric lavage and Induced vomiting. At the Marseille center, a 167 rate of digestive elimination maneuvers was noted In solvent ingestion esses, and 1/2 of these patients presented considerable pulmonary symptoms. When di* festive elimination is necessary,,gastric lavage should be practiced after tracheal intubation. Potential danger was noted in the fact that *uch solvents may be used as excipients as well as principle Ingre dients. When poisoning occurs due to the principle ingredient, the solvent excipient may cause complications. In addition, the use of such solvents as exclpienu is not always known, due to manufacturers' secrecy regarding product composition.-*S. L. R. 6233. JOUGLARD. J., G, FAGOT, B. DEGUIGNE and J. A. ARLAUD. 2 Acut_* ***^^7} poisoning and its emergency treatment. MARS MED 108(9)'. 57l-5*frs.1971.--Acute hydrocyanic poisoning is rare as is " shown by statistic* from the Marseille Poison Control Center: 19 cases during a 3 1/2 yr period. Following a review of the Circumstances of poisoning, which vary according to whether hydrocyanic acid, cyanate derivatives, or cyanogenetic glucosides are involved, the metabolism of ths toxin and 1U phytopathology were discussed. Once it had been Inhaled nr ingested and has diffused into the tissues penetrating the ctUa, cyanide determines histotoxic anoxia by blocking cytochrome osidase m3. Aside from supra-acute poisoning in which death is almost immediate, the symptomatology of thi* intoxication may present 3 phases, as in acute poisoning, or a simple dyspnea with headaches, vertigo, and vomiting in the more common subacute form. Since the blocking of cytochrome oxidase is reversible, any substance with a great affinity for cyanide will tend to release the ferric iron of cyto chrome oxidase and will again allow cellular respiration. Such anti dotes art sodium thtosullaie. methemoglobimzinc agents, cobaltie chaining agents, and hydroxocobalaminc. The last agent with its rapid action and total harmlcssnesa m the ideal treatment for acute hydro cyanic poisoning. Emergency treatment ut the absence of a physician was also discussed.--5. L R 234 SZYM.V,;:r '.VIC7. ar.rt *`^r:"i| rv- lu O SCcordlr' 10 nporis r-ivrnrv ih- vr.irv ,`.r, Kt.fS riV7;tA T I7T5TiTi-iss io7i, - .'rn. ' i-'-Mili* ut 10 yr clinical research <>f ^ye 2 injuries occurring at an industrial renter ar#* reported. The site of the accident, kind of burn, age and < patients and degree of burn are discussed.--C. M. M. /< IVOI. 1 No. 7] 43* #235. BENINI, F., V. COLAMUSSl, C. SIVIERI and G. CERV1 Kvaluatltm.of tti/* anll-pollutlng y . :< m (nr watcra used la <he patrol rhenilral livluslij.. AKCLSP 5TANNA KKltltAltA 23^75^41*1^21. ffi>70.-*T)ic va|Mirs*fornied Over decantation tanks containing petrlferous products were determined and compared with the vapors from an txpertmcntal tank without decantation and therefore without any purification. A marked difference in values was found. The vapors over the decanta tion tanks were within the maximum acceptable concentration standard. The vapors from the other tanks exceeded this limit. The efficacy of anti-pollution purification treatment by this method was thus demon strated.--C. M. M. , ^ 6236. BENIN!. F.. V. COLAMUSSl. G. SIVIERI and G. CERVI. Environmental concentration and atmospheric spread of alkyl lead during procedures of ethylation and methylanon ol gasoline. AKCISP ST ANNA FERRARA 23(4/5): Ja5-400. 1970.~The presence ol alkyl Pb determined In patrol ethylation plant, above and around wagons discharging tthyl fluid and In th* atmosphere both clone to and far from the plant. A considerable part of organic Pb vapor* ar, absorbed and conveyed by cooling ware*. In the petrol ethylation process ltnelf there t* little leakage and In petrol blend* there La none. Pb concen tration* of up to 1.4 a 10 m3 are formed in the external atmoapben when there 1* heavy humidity. The orfanic Pb compound can be found even a* far a* 70 m from ihe aource. On dry ninny day* ther* 1* no diaperaion in the atmosphere, aa the poison quickly disappear* (tri- ethyl pb probably tuna Into cryatalUne compound*).--C. M. M. A G M <237. CABRERA. R. N,, J. J. AVILA and O. BIANCHI. Actinic lichen. ARCH ARGENT DERMATOL 20(1/2): 45-52. 1970,-Thra* case* are presented and the literature U reviewed. Actinic Uchen 1* a derma tosis of photoexposed areas, which appear* afttr exposure to the *un. ft la represented by brownish pigmented plaque* with raised edge* and Anf-shaped configuration and by pigmented or hypochromic, flat, small, isolated papules. This disorder must be Included within the atypical form* of Uchen plnnun.--C. M. M. y <231. HAYES, W. J. Jr. The lnnocuounnenn of DOT for human, demonstrated In the control of malaria. BOL OF SANIT ^ANAM 71): lbl-499. lttl.--Despite the prolonged exposure of the world population to DDT. the only confirmed cane* of poisoning wsr, th* result of massive accidental or suicidal ingestion. The effect* of 1 or more massive dose* of DDT by oral, dermal, or respiratory routs* was studied. Th* results agree with reports of accidents Involving DDT, ind indicate that 10 mgAg Is a threshold dose, causing moderate Ills*** In some and no symptoms in others. The safety of DDT for man Is based not on human immunity to the compound but on the abtUty to restrict Its Intake to low levels, ft is impossible to determine at this Ume whether the dosage* reported to be carcinogenic in mice would nlno be so in human betng*. Tests in mice to determine whether DDT produce* dominant lethal mutationi proved negative, while unpublished tests in rata are said to have been positive; thus, any attampt to suggest that DDT 1* s mutagen in man 1* premature. In relation to tnxym* In duction. an Increase In raiccosomal enxymen was demonstrated la people with occupational exposure to a variety of peaticide* or to DDT alcnr. yet the liver enxyme activity ol worker, heavily exposed to DDT was tsientially normal. The danger of DDT Is to wildlife and not to man. Some countries can restrict its us,, but others cannot possibly do so until adsquats substitutes become available. Indoor spraying of DDT, as praelicsd for malaria control, produces little contamination sod poses an Inslgnific'ni threat to any apecle* and no threat to the inhabi tants of sprayed houae*.--S. K. P. P Z #239. GAFFURI. E. and F. BRUGNONE. Respiratory pathology caused ttv Isocyanates In varnlshers, MED LAV <1(2/3): 151-157. O 1971.--Twenty vanusheri who presented or complained of symptom* E of bronchial asthma or persistent asthmatic bronchitis following the use of polyurethanic lacquers were examined. Seoattixatlon to Iso cyanates was checked by performing intracutanecus testa with a con jugate of toluene diisocyanate with human serum albumin. The occurrence of the symptom* following boih cessation of work and new laquer contact were observed. Inhalation tesla with the conjugate and with acetyl choline were carried out. On toe bast* of clinical observations and symptoms. It was concluded that tome of to* varnished presented signs of sensitisation: to* akin and inhalation teata used to show the presence of reagents were doubtful or negative. Some varnished pre sented a chronic bronchitis a* a consequence of toe irritative action of isocyanates.--S. R. P. *240. GHEZZI. I.. P. MARANZANA and D. ZANN1NI. On asbestos!* to Piedmont. Liguria and Lombardy MED LAV #3(2/3): Ul-llJ. 1971.--Since 1943.~when ihe compulsory insurance against ssbeatosts was started in Italy. 1530 worked were compensated (or asbestos pneumoconiosis m Piedmont and in toe provinces of Milan. Bercamo and G<nn;i; of tu^.c. 12Ci were anil living on March ol, lulu. A.ocatoses of moderate or advanced degree constituted SIT of toe case* (tot* percentage was higher than 50. If only Ihe worker* who were employed In the textile industry and in dock-yard* are considered). Pleural change*, both calcific and not. were radtologically demonstrated In 527 of asbestotic Subjects who had worked in textile mills: among toe O X 2 4967 6&04-6S9J n (Vol. 1 No. 7J 404 O.N , 2 k wk old And the femurs of 16-day mouse embryos or ncuborn mice. With these stains, it was possible to distinguish 3 types of proteoglycans or materials associated with them, which may have, as their major dif ferences, the type Of cross linking to the tiSMic One type was stained by ruthenium red and protamine but not by lysozyme, was extractable with 3 M GC (guanidinlum chloride] and was relatively uniformly dispersed throughout the matrix of the growth plate. The other 2 types were stained by ail 3 cations, were not extractable with 3M CC and were in initimately associated with fibrils. One of these was found on the colla gen fibrils, was relatively scanty in the resting zone near the articu lar surface, relatively restricted to the extralacumar area in the colu mnar zones and appeared to dimish in amount in the hypertrophic zone. This material often had a 640 A periodic array on the surface of col lagen fibrils- The 3rd type also was stained by all 3 cations and was not ectractable with 3 M CG. It was distinguished from the other class of lysozyme-reactive matrix components by the larger volume of dis tribution occupied by the stained material- It also had a different dis tribution in that it was widely dispersed in the resting zone, was restricted to the lacuna in the columnar zone and was absent in the hypertrophic cone. Thus, cartilage matrix and chondrocytes undergo differentiation in the epiphyseal growth plate. 65B4, FOREST, H. S. and E. L. MILLS. (State Univ. Coll., Gencseo, N, Y., USA.) Studies on the plants of the Genesee country (western New York State). VI. The aquatic flora of Conesus Lake! PKbC"-" ROCH EST EffXfcA DSCI 12(2): lTo-138. fllu^Maps. 1071 freed. 1972]* -- included in the ecological consideration of the lake are: a study of the sewage increase and its relationship to conform counts and the pollution of the environment and an analysis of the pattern of P content and distribution in the lake. Preliminary distribution data and quantitative community analysis of the flora, Including 26 genera and 43 spp. of aaglosperms, are presented and discussed.--N. F, G. mm; BPOSSET, A. (Lab. Ecol* Gen. Mus*. 4, Av*. PetitChateau, 91-Brunoy, Fr.) Quelques observation* de printemps au Cap Bon CTunlsie). [Some sometime observations at Cape Bon (Tunisia),] ALAUDA 35(3): 223-226. 1371.--Previous lists of the raptors taken by falconers In Tunisia did not give an exact Idea of the numerical ratio of species passing by Cape Bon. The raptor found to be the most abimdant migrator at the beginning of May 1971 was PemU apivoms; considerable north-south flights succeeded one another without Interruption on the slopes dominating El Haouaria. The 2nd most frequent species was Falco subbuteo. Birds caught from the beginning of April to the loth of May and observed in the bands of the falconers were Accipitcr msus, Hieraaetus pennatus. P. apivoms* Buteo buteo. Circus macrourus. C. pygareuz. B* ntfinus rufin\is. fr. subbuteo. F* vespertinus, FT coiumbarius. tinnunculus, F. naumannj and T, elconofaeTThe'northern migratory subspecies Cbuteo vulpmus was observed passing by Cape Bon but the specimens were gray without the reddish feathers normally characterizing the subspecies. Therefore, populations of the sub species vulpinus with grayer plumage exist and winter over or pass through particular regions of Africa including Cape Bon. With re gard to the most sought after raptor, the sparrow hawk, the falconers were unanimous in their evaluation of the migratory populations over the last 15 yr : towards 1950 there was a considerable drop, perhaps 95%. This observation is significant because a sudden drop In spar row hawks in many regions of Europe was also noted aroimd 1950 and coincided.with the beginning of massive use of agricultural pesticides in these regions. As for the sedentary raptor* of Cape Bon, jf. peregrinm haa retained an apparently intact population. Other species obitwed were Larus audouml. which was observed off Cape Bon, and Bucanetts githagineus, for which the Cape waa an area tar north of us area^of distribution,--5. L.-R. C$ft6. TRZNCA, J. C. (Comraonw. Serum Lab., 45 Poplar Road. Park* villa, Victoria, Aust.), J. J. GRAYDON, J. COVACEVICK, and C. LIMPUS. The rough-scaled snake (Tropiflechis carinama); A dangerously venomous Australian snake" MED J AUST 38-2(16): 801-009. flUis. 1971.-- A comprehensive study was made of the natural distribution and venom effects of T car.natus, a Uule-known species which is noi generally regarded as dangerous to man- Laboratory studies and the effects in animals, and in 12 authentic cases of human bites, with 1 fatality, show that the venom of the rough*scaled snake is comparable ui toxicity to those of the better-known dangerously venomous Australian snakes Its pugnaetry when provoked and us unpredictable temperament make it a snake that Is best left alone The distribution of positively identified specimens shows that it is located Ln the coastal areas of northern New South Wales, southeastern Queensland and north-eastern Queensland. Btappareni aberncMrom large areas of co.iMal, central ar.d far northern Queensland is attributed to its likine for rcla'ivcl. cod. r.,'; ; r* - 65*7. SINGH, A. R., W. H. LAWRENCE and J. AUTIAN. fl'mv. Tenn. Med. Units, Memphis, Tenth, 38103, USA.) Teratogenicity ot phthMate I from pa&wfyi flhMde tteOTfefhgrttotsff-' cal solutions. To ascertain the effect these plasticizers might have upon the fetus, a teratogenic study was undertaken in rats using 8 phiha late esters. Six of the philwlutcs, whoM.- acute mlrapcriloncal LDjg values were below 10 ini. kg, were administered to rats at doses representing I '10, 1/5, and 1'3 of the acute LD^q dime on the 3th, 10th, and 15th day of gestation; the 2 less toxic compounds were injected at levels of 5 and 10 ml/kg. Distilled water and normal saline were tested at 10 ml/kg, and cottonseed oil was tested at 6 and 10 ml/kg. Untreated animals were used for control values. The number of corpora lutea ranged from 52 to 65 per group of 5 rats, with no apparent distribution according to treat ment. Embryo-fetal toxicity ranged from 07 to a high of 98,2%. Fetal malformations ranged from 0 to 100%, both for gross ana skeletal abnor malities, with skeletal defects generally being more common. Fctusee from all phthalate-treated groups were smaller (p < 0.01) than the un treated controls. Absence of tail, anophthalmia, and twisted hind legs were the most common gross abnormalities, while elongated and fused ribs and abnormal skull bones were the most common deformities found in stained skeletal specimens. 6668. COURTNEY, K. DIANE (Perrin* Primal* Lab., Perrin*. Fla., 33157, USA.) and JOHN A. MOORE. Teratology studies with 2,4,5-tnchloronhenoitvacetlc acid and 2.3.7,6-tetrachlorodibcnto-P-dioxin. TOXICOL APPL PHARMACOL 30(31: 3M-4037 I71(recd. 1972^--The herbicide 2,4,5-triehloraphcnoxyacctlc acid (2,4,5-T), and 2,3,7,8-tctrachlorodibonxo-p-dioitn tTCDD) were teratogenic in the CD-I, DBA/2J, and C57B1/4J etraine of mice. Both compound! produced -cleft palates and kidney malformation*. When thca* compound* were administered in combination, the activity was not potentiatsd at the doses employed. In the CD rat, 2,4,5-T was neither teratogenic nor fetotoxic. However, TCDD produced kidney anomalies. Prenatal admuiiatratlon of 2,4,S-T did not affect the poctnatal growth and development of the CD rat. 6589. AGNEW, WILLIAM F. and JUNG TA CHENG. (Huntington Inst. AppL Med. Res., Pasadena, Calif., 91105, USA.) Protein binding of tcllurium-127m by maternal and fetal tissues ot the rat. TOXICOL APPL PHARMACOL 20(3): 3W-3i6Tlllu5. lSHjrecd. l97l).--ln vivo and in vitro metabolic studies with teUurtum-127m have demonstrated by the us* of several isolation procedures that Te is tightly bound to fetal and maternal eoluble proteins of the rat. Studies on whole blood have shown that T* is bound uniformly to au serum praern fractions, and that the binding process appears to be dependent on the presence of a red blood cell enzyme. Binding of T* in soluble protein* of plasma and brain ia inhibited by p-chloromercuribenzoate (PCMB). A detoxification function for the tellurium-protein association ti proposed, and its possible rela tionship to the induction of congenital communicating hydrocephalus in the rat is discussed. 6590. SASAKI. KENICH1. (Dep. Pathol.. Hokkaido Univ. Sch. Med., Sapporo, Jap.) Histological chances ot the liver in Eck's fistula dogs following cooper administration wnh special reference to hepatic coma. HOKKAITO jMId SC) 46(2): 101-112. Ulus. 1871. Tin Jap, with Engl, aumm.1--Hepatolenticular degeneration ia characterized by the appear ance of the Cu granule* tn the Itver and brim stem: cirrhosis is also observed. As Cu administration alone never produces hepatic cirrhosis, a relationship between abnormal Cu metabolism and cirrhosis was sought. Livar injuries and a marked histological changes, mainly degeneration, were seen in the brain etem of Eck's fistula dog suggesting circulatory disturbances in the liver to be an important factor in the development tf hepatolenticular degeneration. The effect of Cu administration to the Eck's fistula dog was Investigated. Cu administration for 1 yr caused no significant change in the liver except for the vacuolar degeneration of hepatic cells. The administration of Cu for 5-7 mo. to the Eck's fistula dog (1 mo. aftsr operation) caused fatal hepatic coma accompanied by a marked jaundice. Histologically focal and extensive necrosis, fatty de generation apd irregular proliferation of connective tissue fiber were seen, indicating the initial picture of postnecrotic hepatic cirrhosis. A diffuse appearance of Cu granules was seen tn the hepatic cells of Eck's fistula doc. The impairing factor of the liver itself and the intoxicating, action of Cu is probably required for the development of linking histo logical changes anl Cu deposition in the liver in relation to the abnormal Cu metabolism. A hepatic circulatory disturbance i* a possible impair ing factor and might also be responsible for the development of coma. -J. C. 6591. IWANCZUK. IRENA and JADWIGA KELUS. (ut. Chocimska 24, Warszawa, Pol.) Wpljrw chloru i jodu czynnego na przezywalnosc jaj robakow Jtlitowych ezibwieka: Ascanu* iumbricoides i enterobus vermiculans- w basenach kaptelwych. (The influence of active chlorine and indine on The viability in swimming nonls of cues of human intestinal . - A-caris ticoidcs ana r.nierQbiu-i vcrmicuiuris. 1 ROCZ l A -. -. ...L i'.to 33 3. ilii-iui. ...us, {Engl, anu Ku.s,.umm.) -- Lnrgn ry,\- 'i.t: of eggs of human intestinal helminths, mainly E.. ver* miculnrn and Taenia sp., as well as A. Iumbricoides are present in pub lic swimming pools. An Investigation was undertaken on the ovicidal ac tion of I and Cl used as water disinfection agents in pools. The investi gation was earned out on the eggs of animal nematodes. In place of the egg* of E. vermicularis, those of Aspiculan* tetrantera were used, in OLX 4968 2 S>5 k 'Y O 605 (October, 19721 9294, LUTSFNKO, l. A, (F. F. FrUmnn H> s. Him live., Mimruw, M .) VoprOKV ^ll|,i,n\ li ml.i |M l <^>v, nln`h> mi MiJ'n-lnvkh km diivkli q rud n.i Kibrik,ikli Ci.Ua, (luduMi l;il HM'.h'm* In Ihr rnn,i,r*l nilI mi> uf Y sulfide copper ores a( mills rn tKo Yr.tls,] " CmC IK rUGF"ZAnOT. v rmoni-nrTfiuvn3701 [tngirsu117.7-'-i)ygu-111 c investigations 2 of 3 milts show that Inthp course of floutional processing of copper ores, the workers are exposed to dust effects from the treated ores and their final concentrates, and to decomposition products of flotation agents (hydrogen cyanide, CS^ and H2S), noise, vibration low tempera* lure and an elevated relative humidity. The sulfide copper ore dust exerts fJbrogenlc and a mildly toxic action. The copper-concentrate dust displayed stronger general toxic action than did the ore. The maximum permissible concentration of sulfide copper ore dust con taining less than 10^ free silica should be 4 mg/m . Health measures aimed at Improving work conditions are given, *-K. M. E. J.0 92*4-930* 9?99 . KS'KlN, 1`. I. Opvi I'Hth-iilrlirr.Mkh Innledovuna pylovittfn fnktom n;i slmkM.ikli Ku/Ii,in.s,i /:i gg. )Sovb'i o.MiorlMnrc with hviionlc studio*! of mu' dust factor in coal mine* oi the Kuzhetsk ITatiln Iron) iiflWOdB.I GIG lit PHOF ZABOL 14U0F 7-11." 19^0, (l^ngL sum.j*-lnvcsiigations covered all methods of coal extraction and excavation of enclosing rocks undrr diverse mining and geological conditions by using various means of dust control. Functional depend* ence of the case-finding frequency and service record prior to recog nition of pneumoconiosis among miners wjih a service record of 10- 20 yr upon the factual weighted mean air dustiness during the shift was found and expressed In terms of mathematical formulas. A compara tive analysis of the after-effects of exposure of miners belonging to different occupational groups to an aerosol with a small silica content over the last 15 yr is given. In hydraulic mining of coal the air dusti ness is lower than with other methods of coal extraction.--C. M. M. 9295. ERAMYAN. S. G.. E. A. AGABALYAN, and D, A. TASHCHYAN. X (Yerevan Inst. ind. Hyg. Occup. Dis., Yerevan, USSR.) Sravmtel noe Z Uuchenie slstemy avertyvaniya krovt pn razlichnykh nespetsifeches- kikh sabolevatuyakh legkikh pylevoi 1 nepylevot etiologii. (A compara tive study of the blood coagulation system in different chronic nonsooCt/ie pulmonary affcctions of dust and non-dust etiologyT GK; TR fROFZABQL Mili). '32-33. 1970. [fengl. sum.]-Hie slate of the blood coagulation system was studied in patients with chronic nonspe cific maladies of the tunes such as bronchitis, emphysema, ptieumosclerosis of non-dust etiolocy in 43. suppurative diseases of the lungs In 105 and pneumoconiosis In the Cu industry of Armenia In 49 cases. The nature of disturbances depended upon various combinations and Intensity of Inflammatory and flbrotic alterations In the lungs. Aa the degree of respiratory Insufficiency and severity of the affection gained In Intensity the blood clotting capacity increased. In patients with bron chitis, emphysema and pneumosclerosis activation of the blood coagula tion ability and of the anticlotting component oould be recorded. In pul monary suppurations a rise of the coagulation capacity went with In hibition of the fibrinolytic activity of the blood. Pneumoconiosis activa tion of (he anticlotting factors and the fibrinolytic system were ciuracberlstlc.--. B. 9296. BODE, C. (Med. Vlniversitaetslilin.. Marburg. W. Cer.l, - CHRISTIANE BODE. H. GOEBELL. H. GODBER5EN. and G. * STROHMEYER, On the pathogenesis oi ethanol-induced lipid accumula tion in the liver: U. Effect of stimulation ol the o-clvrerophosphale cycle on metabolic chances in metabolic changes'in ihc liver caused* by ethanol. hOrM METAt) llS i'll. i82-lfeo. Ulus. Is7fl.-. The effect of hyperthyroidism Induced by L.-triiodothyronine upon the oxidation of ethanol and ethanol-dependent metabolic alterations was Investigated in male rats. Hyperthyroidism reduces the accumulation of D-glycerophosphate and the increase of the reduction of the cyto plasmic NAD-system caused by ethanol. This effect is due to the marked elevation of the activity of o-glycerophosphate oxidase, the rate limiting entyme of the o-glyrerophosphate cycle. The accumula tion of triglycerides in the liver by a single dose of ethanol Is distinctly leu In hyperthyroid rats than In euthyroid controls. In contrast, the production of d-hydroxybutyrate and acetoacetate Is stimulated. The preferential esterification of long-chain fatty acids in the liver to triglycerides following ethanol application la probably partially caused by the Increased a-glycerophosphate content. The activity of alcohol dehydrogenase lADH) calculated per gram of liver tissue, deereases In L-triiodothyronine treated animals. Tht total activity of ADH per animal did not change significantly because the liver weight increued. The elimination of alcohol from the blood la slightly elevated In hyper thyroidism. 9297. VORONTSOVA, E. I., and V. B. BATUSHKNA. (Inst. Hid. O Hyg. Occup. Din,, Acad. Med. Set. USSR, Moscow, USSR.) Profilaktlka X pnevmokonlotov, fPrevcntion o( pneumoconiosis.) GIG TR PROF Z ZABOL 14(10); 4-7. 197Q, (Engl, sum.)--Concrete rvamplrs of individual mines and enterprises, where hygienic requirements were met to the full and the pneumoeoniosls Incidence gremly reduced, were reported, (mplcmrntatlon of a set of legislative, technological and unitary-technical nieasurrs, niedico-biologicai prophylaxis and per sonal hygiene can secure a stilt greater reduction of the incidence of pneumoconioses.--C. M. M. 9296. VERTKIN, Y.!.. ruid Y, ft. MAMONTOV, il.i'mur.rml Sami, 52 Hy(f. Med. Inst., Leningrad, I'SSft.) O sostnyanu bronkh`>-lei:rti'hnogo na proizvodstve udclii iz poiivwilkhlonda. * g?UtUu>'|E`(fcwAjywrtewielwHHiTe mitm in worker* mnwofacrurtnc r'TpV --ol "ir.'T'J T7^ articles made of poUvinv-hMoii'l'' v/itp lA.jijuiivd t,; ,!. ; ui. erablr number of Uum h.id jJfer.Tions ir, ih- rrsoit nioi i .u;:ans typified by Changed broncftovasculax pattern ana increased pulmonary ventilation at rest. These should most probably be ascribed to the fleet of adverse factors of the industrial environment and particularly lo Intensive and long-term exposure to polyvinylchloride dusi.~C. M. M, ,0300. MIKHAILOVA, U, T. BURILKOV, and K. KOLEV. (In*t. Ind. Hyg. Occup. DU., Sofia, Bulg.) MineraLogicheskoe issiedovanie D otloihenii v legklkh pyli i ee snachcnie dlya profesaionarnoi patologli, O {Mlneraloelcal srudv of dust deposited In the luncs and its significance X in wrcuphtional pathology. (~ GIG Th t*RC)F ^AlSOL~ fltlO): 22*25, Z lu7o, (tngl. sum.]--Possibilities of studyint; and expert evaluation of pneumodocdoacs revealed throuph tsolailon and mincraloglcal analysis of the dust retained In the lun^s arc described. The (ormamide method as proposed by Thomas and elaborated further by Einbrod wax employed to Investigate the pulmonary dust of a furnace constructor with a ser vice record of 28 yr. Clinical, pathologico-anatomlc and mineraiogicai findings are contrasted* Their coincidence emphasizes the value of independently conducted mineraiogicai analyse* of the dust deposited in the lungs. These investigations acquire particular significance in cases involving inhalation of mixed dusts with Low content of free silica. ~C. M. VL 9301. PALTSEV, Y. P. (F. F. Erisman Res. [nst. Hyg,, Moscow, USSR.) Voprosy bor'by s pyl*yu na teplovykh elektrostantaiyakh. A (Dust control in thermal electric power stations.1 GIG TR PROF M za&6l M{10): l5*lS. 1&70, (EnuU sum.|A number of techno- O logical processes and operations at thermal electric power stations X release fuel and cinder dust, whose concentration may be well-above 2 the maximum permissible level, into the atmosphere of work premises* Workers exposed to a protracted effect of such dust demonstrate the presence of chronic disorders of respiratory organs and skin. Acute poisonings are possible following exposure to the effect of high con centrations of the 5-rich fuel oil cinder dust containing V and Nl com pounds. To prevent occupational poisonings, sanitary-technical (aspiration and steaming units, sealing-off of the equipment, pneumatic cleaning, hydraulic wash-out) and hygienic (anti-dust respirators, protective pastes) measures were recommended* Introduction of such measures at a number of electric power stations.helped to drastically reduce the concentration of fuel and cinder dust in the atmosphere of work premises and to do away with acute and chronic occupational diseases.--C. M. M. ---- ---- --9B--**--' "i* f",.9*4*rtnv nftlvW A * lf| iMM n, . SCHMIDT, (Inst. Rechtsmed., Univ. ErUngen-Nuernberg, Erlangen, W. Ger.) Zur Toxicitaet und Stoffwechsel von Amuiotriatol beim Mensch*n- (Toxicity and metabolism of aminotmtoie w man.] ARCH TOXI KOL 27(11: 13-id. 1370[recd. 1971J" (fcngl. sum.[--Alter ingestion of 20 mgAg of aminotriasoie [a herbicide], a 39 yr old woman showed no signs of intoxication. From a urine specimen taken some hours later, unchanged aminotriasole in an amount of 100 mg/100 ml could be isolated and identified. 9303. PELJKAN, 2EDNEK (Univ. Hosp., Groningen, Neth.), and EMIL CERNY. Toxic effects of some "mono-N-butvl-tm compounds" *i Oft whits mice. ^riCuYoxiRCL' ITH): ^-8'4. n76jrecJT 197177 (Ger, w sum.]--Thc toxic effects of **mi>nr>*n*ixityi*tin>trichlorute,<1 "moiio-ntxilyl-t*lr^- (2*i*lhyi-hi'xyl*mcrc;i|k.*.)L't't:itcr`, ''mouo-n-l>ut>i*tin ;u*itl :md `'numo-n-Uityt-Kiiutin {irHi"' on white nuce were investigated. These compmmtlN were admimrtered hv means of a stomach tube tn a single dose of 4000 mg\r body weiglit, at the start ol the experiment, AU mice were sacrificed 24 hr after administration. The clinical course and macroscopic findings in all experimental groups indicated gtneral signs of acute intoxication. The histoloincal findings in the *'mono*n* bjiyl-tin-trichloride" group showed prououneeu changes in the digestive tract, where hemorrhages m the mucous membrane and n the inner layer of the gastric and intestinal wails were found. In other experimental groups of mice, steatosis of the hepatocytes and an irregular steatosis of the renal tubular epithelium were observed. 9304 . srKIWNdV. M. A., and V. A. POTFKHIN.V (N.i*.a*iusnrtsk Posigiad* Md. Nowikurnetsk, L^SR.l Sostuvame sokrautei'noi (unktsi) serdtsa i arterial'nogo tonusa u bol'nvkh pnevmokoniozom rabotnas ugleobogatiternvkh (abrik. jContracnie function of me heart and arterial tone In pneumoconiosis-sirtckcn trmale wnrkrra~ot dressing nulls. \ GIG fa |>hqF ZA^oE--FTTf0IT!5^(1571 flus.T3T0. [Ingl, sum. j-*RcuU# ot a balbstocardiograph (DCG) and osciliograph) X ^ OLI 4969  ilO'j VJ13 >7 fVol, ] No. 10] 080 >ii H2 wi/ikri*. anil 2D pi uciieallv Iwallhv .......... art* arvMw.cd. t>ci an|\cmcul s n( t'.* contravtilc (uitttitm *( U>* nivcai`iUuM into iht arterial tone wer** netcil, I't'C triictutv^ n**l the pri'Suuc of latent forms nf hcmuflvnamic disorder.*. Su;i"- of right heart h>pcrfunctlin became apparent earlier on the l>( (J (h.m on the KG. In most patients the absolu'c arterial pi<>.viir (ir.uiis were normal, but falling or the oscillatory index, asymmetry o^ the curies and symptoms of respiratory dystonia occurred frequently.--C. M. M. 0305. DZUKAEV, Z. E., and T. A. KOCHETKOVA. (Inst. Ind. M H>g. Occup. Dis., Acad. Med. Sci, USSR. Moscow, USSR.) K voprosu y 0 tsinkovom pnevinokoniore 1 ego rentgcnomorfologichrskom oto- brazhenU, (Eksporimontarnoc isskdovanie). (Kxperlnient.il study of tine-induced pneumoconiosis and Us roentgenumurplWTuificar picture. | xifl TR PR<yr2AfiOL' 1-idU): 3H-41. 1970. |EngL sum.|-An expert mental investigation was carried out on 38 rabbits which received intratraeheAlly a tine oxide suspension in saline (40-80 mg leg body weight once or twice. Zinc and lead oxide proportions were 72*78 and 11*15$ respectively* The rabbits were saenfied in 3.6 and 9 mo. Some of the animals of the latter group were subjected to repeated poisoning with sine oxide. Microscopic examination of the lungs taken from the sacrificed animals demonstrated manifestations of catarrhal bronchitis, gradual development of interstitial pneumonia resulting in pneumo sclerosis and formation of small cellular-dust loci with collagenous fibers proliferating around them. Intravital chest roentgenograms taken in the animals failed to reveal the great majority of fibrous changes. Those of the excised lungs reflected alterations of certain intensity in the shape of a condensed and deformed pulmonary pattern and some times of a reduced transparency of the pulmonary tissue.-*C. M. M. 0306 . AI/BERTON, N. I, nd G. M. BALAN. (Karaganda Inst. Ind. 0 Hyg. Occup. Dis., Karaganda, USSR.) O stimuhruvushchem vUyanii X prodigiozana pri lechenli khronicheskikh bronkhitov i pnevmonli u y bol'nykh pnevmokoniozom ugol'shchtkov. fStimulating effect nf prodlgloslnc in the treatment of chronic hro'nrhitrs and pneumonia* in patients with coal miners* pneumoconiosis,f CIO TK PROF ZADOL 14(10); "35-36. *$76. [Engl. sum.]--The elflcacv of prodigiosan in the treatment of miners suffering from chronic bronchitis and pneumonia was studied. 1)118 drug was given in association with antibiotics to 144 patients, with 53 others not receiving it who made up a control group. Under investigation were clinical and immunological indices along with the microflora in the expectoration. Prodigiosan was help ful in improving the clinical condition of the patients and the external respiration function. This was accompanied by a rising complement and phagocytic activity of the leucocytes, an increase of the lysozyme and staphylococcal antitoxin titers. In controls these improvements were leas ostensible.**J, G. S. 9307. SEMAWKIV, L V* Aktivnost' tserulopbzmina prl pncvmokoniozakh i pylevykh bronkhitakh. fCerulopbsiTun activity in pneumoX CQniOSia and dust-induced bronchitis.| GIG TR PROF ZAUQL 14 Z (10); 4-ii. 1970.--The ceruloplasmin activity was studied m the blood of patients with pneumoconiosis* dust-induced bonchitis and In workers where the percentage of free SlOj in the polymincral 4fci*t varied from 0.2-23 with the high level oT the dust content. An increase in the ceruloplasmin activity as a non-specific parameter appears in the early stages of pulmonary diseases of dust etiology and in workers with prolonged (10*15 yr) assignments in a dusty atmosphere. In patients with chronic bronchitis and pneumoconios there was sn increase in blood plasma activity. With progression of the disease these changes became persistent* Testing for increased ceruloplasmin activity is recommended as preventive measure. --N. L. G. 9308. DZIZINSKI1, A. A,, and L. Y. ZISSER* (Med. Inst., NovoM slbirsk, USSR.) Pronitsaemost' krovenosnykh kapillyarov, gepann i O fibrlnoliz v patogenezo i klinike slUkoza i olovyannogo pnevnokomoza. X (Blood capillary permeability, heparin and fibrinolysis in the pathoy genesis and clinical picture of silicosis and tin-imiuceri pneuniviennio- sis.i etc tr HtffrmdL nrrorsz-Sj. nna^ihen.,. with-- iTHcosiS. $u-indueed pncumoronuitfix and worker* in faetorv eotwliltons leadinglo mWrosu: were studied. In patients with.tlnse dis-Tdcr* and those suspected to have silicoses there was a tendency for capil lary permeability to increase, along with hvper-hrparincmia and activation of fibrinolysis. The earliest and most frequent chance occurred in the fibrinolytic activity and heparin in the blood. The in dicated enzyme shifts preliminary- to capillary permeability disturbances. The syndrome ol capillary-trophic lnsuUiciencv pb\ed a role in some of the pathogenic bases of pneumoroniostS.--N, L. G. 9309, NAl'MFNKO, I. M,, and M* 0. RAPPOPORT, ifr?:. Ind. 2 Hyg. Occup. Dis., Kiev, L'SSIL) Stravmtei'na.a oiscnka dcidtivva elektri svarochnuga acrozolya pn svarke cleairodami * ruf.iovvm 1 margantsevym pokrytiem na tkan* legkikh. |A comparative study of the effect of electric welomg aerosol on the lungs Purine weiuinc with rutile^and manganese cohered electrodes,)' ilG TR ^ROF ZABOL H(lO): 42-44, 1070.--Dully inhalation of electric welding aoronol waa MnMlrri In white In chambers willi a die.I rnnrentrution of 150- ZOO mg/tn^. In others electric welding du-it wax administered intra* trachmlly in t)hys|n|<>r'ie.nl solution. Of these, 1/2 were exposed to the products of rutil*- die other 1/2 to Mn ones. Tlie palhuniorpliulogtcal changes from difh-rrni types of electrodes were similar. They were characterized by cellular-dust and fibrous foci, thickening of tissue areas alternating with emphysematous areas and sclerotic changes in the pulmonary stroma. With aerosol from the Mn electrodes, there was swelling of the vessel walls and perivascular edema, symptoms of toxie activity. Growth Of ceil elements In pulmonary tissue was associated with considerable changes in the content of nucleic and ascorbic adds. This was more sharply pronounced under the effect of aerosol from the Mn electrodes,--N. L, G. 0310. LAALE, HANS W. (Dep. ZoolH Univ,, Manitoba, Winnipeg, Can.) Ethanol induced notochord and spinal cord duplications in the embryo~Qf the zebrafish. Brachydamo reno. J EXP'SSoot,'"lllliV. 51-64. illus. 1971.--Embryos of ft. feno. stage 10 (Hisaoka and Battle, *58) were exposed for 24 hr to gradeffconcentrations of ethanol from 1 to 3$. Developmental abnormalities Included defects of the eye, i,e.y approximation, confluence and fusion of the optic cups mld-ventrally; and duplications of notochord and spinal cord. Duplication of the spinal cord in the hind brain region has not been reported previously. The duplicatory effects are discussed and a mechanism of duplication by infolding roof plate material is proposed. Z 031 r. GINZBURG, E. A*, M. V. SHILOVA, M. Y. KORNEEVA, E. V. LEVTONOVA, A, M. SERGEEV, V. I. ROMANOV, M, S. FILONENKO, E. S. IVANOVA, M. P. ALTYNOVA, G. A. ZUBRILINA, and U. A, SERGEEVA. (Mosc, Res. Inst. Tuberc,, Min. Health RSFSR, Moscow, USSR.) Plevral*naya forma neprofessional'nogo asbestoza. [Nonoceupational asbestosis of the Pleura.) KLIN MED 48(12): bb^JO. Illus. 197d[rc'ed. 1971]. [Engl. summ.|-*The paper deals with clinico-rocntgenological data of 488 persona with pleural calcifications, as well as the results of epidemiological analysis of the incidence of these pathological changes. The absence of any regularities of the spread of calcifi cations In the family and village, as well as the absence of relation between the Incidence of these alterations and water sources testify against an infectious character of the disease. Apparently, the changes are a pleural form of asbestosis: the X-ray picture of pleural asbestosis is similar to that described In the pertinent literature. The age-specific peculiarities in the spread of this pathology point to the protracted epidemiological contact for the development of calcifications, this also being typical for pleural asbestosis. The incidence of calcifications in villages sharply rises with approach to deposit*! of asbestos-containing caps ami Is greatest in the vicinity of the Inttrr, Grains of asbestos were found in the street dust in populated areas where there are persons with calcifications. The literature contains no information on the possibility of development of pleural asbestosis In the absence of enterprises engaged in the mining of this mineral.--K. M. E. X 2 9312. POLAN, C, and P. T. CHANDLER. (Va. Polytech. Inst, and Sate Unlv., Blacksburg, Va,, 24061, US*,) Metabolism ol 14C- carbonvl labeled Supraide by l&ctating cows. 3 fcMftY SCI' 5415): B47-8&3. Ulus. 1971.--The metabolism ot a new organophosphorus inscctide, ftipracide, intended lor controlling alfalfa weevil and other Insects was studied in lactatlng cows. The labeled compound was rapidly metabolized and eliminated from the bovine. The major routes of 14C excretion were urinary and respiratory. One to two % of the label appeared in milk, but no parent compound was present. A small percentage of milk radioactivity was idcntllied as a sulfoxide and sulfone metabolite. The principal radioactivity iound in milk was retained in the noncxtractable traction. This was probably due to Incorporation ot 14C-metabolites into synthesized natural nonfat solids of milk. F p y , mr L,acrt (ivommunenoso. non), FAurtCY, da Mia H. Christensen, id 0LE-.F: N1ELSEV in P V.C and 0i occurrtnr. nI yR"** TMui*iohLaenmmod'iiiaiiluyslis umml: AIfptrUelvimt.ilnliaurys.commmunTMicatiToni. yrpfnod 3 isolated ease, of hepatitis .ere observed within a period of 2 mo. in a h.modialvsis unit. The rases occurred m 3 panents durim; leslldd nl new h. ti. vltalisis l'|tl:mtcnt. t.ucr h.^c,v in 2 r-ai.fills iv,i h. imiii, and rhanu-es as in "viral hepatuis. r,,,vci,ve:v. Fr.tn, the tesied bl.d tubmi;*, nunuf.ctured M'vinyichloride. d.ethilphthalatr was washed out in an amount ol 1Q-2G mg ( aqueous perfusate. From the tubings normally used in the department this compound was not released on perfusion and the symptoms disappeared rapidly when treatment with the use of these tubings was resumed. OLI 4970 -J# 10523*10533 J* ivol. 1 NO. 11) 772 10523. MIKULINSHI, A* M., L. T. SUDOMNA, N. S. LASHCHEKKO, concentration Increases parallel to the rising temperature Inside the O N. N. KOSSOVSKII and 1.1* AZOVSKAYA, (Inst. Ind. Hyp. Occup. Dis.f tanks undergoing cleaning. The disease-incidence among female wor T Tlflis, USSR.) Ptziologo-klinicheskie osobcnnosti vibratsionnol toleznl kers is elevated by comparison with those doing ship repair work. u raboUyuShcftlkh s vysokochastotnvm vra.shch:*tcl'fjym instrumcntom There is a higher rate of cardlo-vascular diseases, reproductive sys ) 1 puti ee proftbktlkl, ICharacterlsiics and provenUon of vibration dl- tem disorders and respiratory disorders. Recommendation, for the i case in workers handling hii-h-frcqucncv rotary tools. CIO Tit PROF Improvement of work conditions are given.--J. F. L. % ZABSL 15(12): 15*18. 1971jrccd. 197$]. (bnpl* "summ.]Vibration 1 disease was diagnosed in 19.5% of 296 fitters. The disease manifested Itself after a service record of 5-7 yr. Its characteristic features 10529. SOETHER, HALVARD. Yrkesalmder under hogst. (injuries *1 * In forest wprk.1 TIDSSKR SKOGBRUK 79(1): 35-41, fllus. T97E ' were a mildly pronounced vegetative-sensory polyneuritis or anglodystonlc syndrome and degenerative-trophic chances in the bones and lEnuL summ.|--in forestry there are more registered acddcnts/1000 man-years worked than In any other Norwegian trade or Industry. I vertebral column with no concomitant lesion of the internal organs. Most patients were able to continue their occupational activities. A total of 101 cutters were studied in flstlandct and Trftndelag. Every 7th cutter suffered from Injuries during the season 1969/70. This Neurotrophic disturbances of the hands prevailed, with a marked pain was 143 ln)urlc*/l 000 man-years worked. Many tailed to use safety component and reduced muscle performance. Workers handling abra equipment, especially the older cutters. Only about 1/2 had first aid sive discs tor processing developed vibration pathology after a lapse equipment with them.--J. F, L. of 9-12 and 16-19 yr. In this group the angiodystonie syndrome was of i moderate intensity with a mildly expressed pain component. A new pneumatic tool provided with vibration damping arrangement was de 10*30. MCBRIDE, M. E. (Baylor ColL Med., Houston, Tex., 77025, USA.), L. F. MONTES, W. J, FAHLBERG and J. M. KNOX. Microbial , vised and a rational work schedule recommended,--J. F, L, flora of nurses' hands: L Quantitative differences In bacterial ponu- , 10524. SOLOV'EVA, V. P, and A. S YURCHENKO. (Inst, Ind. Hyg, O Occup. Dis#l Acad, Med, Sci, USSR, Moscow, USSR,) FUiologlcheakaya kharakterlstUa napryaahennosti truda prl rabote za pul'taml uprav- latlon between nurses and other occupational ctoupT INT J DERMA TOL 11(1); 49-53. 1972. |Fr. and Span, summ.j--The microbial flora of the palms and interdigital areas of the hands in nurses was determined quantitatively and compared with a control group. The lenlya, [Physiological characterization of the intensity of work at eontrol desks.| GIG TR PROF ZABBl IVj):..13-lf. 1671. lEngL iiiram,] numbers of bacterla/em on the palm ranged between 0-log 3.81 in nurses and log 1.54-5.03 in controls with means of log 1.94 and 2.79 --Result, ofa comparative investigation Into physiological shifts (EEC, and medians ol 2.00 end 2.69 lor each respective group. The bacterial ECC, rats of information processing, speed of oculo-motor reaction, etc.) occurring under the effect of work at control desks when on duty ind In a laboratory are reported, A relationship between ehingee of counts from the webs ranged from 8 to log 3.47/em3 in nurses and log 0,48-3.43 in control!. Mean values were 0.10/cm3 for the nurses and 1.89 for the controls. Medians were log 0.94 and 1,67 for each physiological functions and the Intensity of work, determined by the group respectively.--J. F. L. mount of the Incoming Information, the senee of responsibility and tbs emotional stress, was discovered. The data was used In elaborating 10*31. OLDER, HARRY J. and BERNARD J. CAMERON. (Bio- 'criteria of the Intensity of work at control desks.--J. F. L, TechnoL, Inc., 3027 Rosemary Lane, Falls Church, Va,, 22042, USA.) <- 10*25. FILATOVA, y, S. and V. A. ANTONYUZHENKO. (Inst. In<L Human factor! aspects of air traffic controL NASA (NATL AERONAUT SPAdE ADM) CONTRACT REP CRI1957): 1-163. Illua. 1972. Hyg. Occup, Die,, Gorkt^MWf Glglenlcheslde uslovlya tnida 1 pro* fesslonal'oaya zaholevaemost' rabochlkh proizrodstva auspenzionnoeo --This report presents an overview of human factors problems asso ciated with tbs operation of present and future air traffic control sye- tems. A description is Included of those activltiee and tasks per formed by air traffic controllers at each operational position within DiseoMln^^Keln^wOTkers in the present system. Judgmental data obtained from controllers con contact wuh polyvinyl chloride was studied for IS yr (1955--1968). cerning psychological dimensions related to these tasks and activities are also presented. The analysis Includes consideration of psycho- Introduction of Improved machinery and ventilation In the premises contributed to the Improvement of hygienic conditions. The clinical picture of the poisoning changed accordingly, with a longer period of developnent. However, the existence of technological operations which do not yet meet hygienic requirements, led to a subsequent rlee In the air concentration of vinyl chloride and to the appearance of new cases physiological dimensions of human performance. The role- of the human controller In present air traffic control systems and his predicted role In future systems Is described, particularly as that role changes as the result of the system's evolution towards a more automated con figuration. Special attention is directed towards problems bf staffing, training, and system operation. A series ol 10 specific research and of M A considerable variability In the development projects are recommended and suggested work plana for clinical uifflliesmffflhs'Df't'hronic vinyl chloride poisoning as a func their implementation art Included.--J. F. L, tion of the environmental air contaminations was established. A eerie, of measures designed to Improve the air of work premises its sug- gested.--J. F. L. 10532. MORGAN, K. Z. and E, G. STRUXNESS. (Health Phys. Dlv., 1092*. tOMAKEV, P, L, S. N. POPOV, A. M. TYUTON and Y. M. 8HAPKAITS. (P. F. Lesgaft Inst. Phys. Cult., Leningrad, USSR.) 0 T vllyanll tattyat11 spot-tots na chastotu 1 dUtel'nost' nekotorykh zabolevSnU. (Effect of sporting activities on the Incidence and duration of some diseases.! SOV MED 34(2): 1&0-103. 1971. |Engl. lumm.j-- Tbs frequency and duration of acute affections were studied in sports- men end In oon*athletle persons. Severe colds were much less frequent In the former while dlteaaee of the locomotor apparatus were more frequent. This Is attributed to the stress sportsmen are subjected to during training and performance. In sportsmen diseases last for a shorter time. Sporting activities do not change in the incidence of "acute' morbidity.--J. F. L. Oak Ridge Nat. Lab., Oak Ridge, Tenn., 37830, USA.) Criteria for the control of radioactive effluents, INT J ENVIRON STUb 2(2): 111119. Ulus, 1971.--The risks to the population from the U.S. nuclear energy Industry are considered to be very small In compurlion with other environmental risks. However, they are not zero and, on the as sumption that radiation damage Increases linearly with the accumulated dose, they can be expected on a statistical basis to result in a few deaths In the exposed population. Thus, the routine operation of these nuclear power plants may cause about 18 deaths/yr and the serious accidents, which may occur at a frequency of once every 50 yr, may add another 6 deaths/yr on the average. This is considered to be a small price to pay relative to the real but less-well-defined environmental risks from atmospheric pollution caused by fossil fuel power plants. Assuming 10*27. RETNEV, V. M. (S. M. Kirov Inst. Postgrad. Med., Lenln0 grad, USSR.) Nekotorye voprosy glgteny truda v svyazl I kompleksnoi T avtomatlzatsleL (Industrial hvclene in relation to comolcx automation.) GIG TR PROF ZaIOl UUj: 9-12. 1671. | En^l. ittniD. j--'Complex automation generally leads to improved working conditions. Hygienic the proper selection of a reactor site and all practicable precautions Is the design and operation of a nuclear power reactor, adequate radia tion protection for nearby populations can be assured by concentrating health physics attention on the critical radionuclides, critical pathways and critical segments of the population. advantages include: favorable worldns conditions in most premise* ac comodating control desks, reduction of the numtar of operators enraged it work places presenting occupational hazards, and a decrease of phy sical efforts. Hygienic shortcomings attending complex automation are ol a temporary and avoidable nature. They comprise a consicerable nervous and psychic stress owing to a large volume of information and adverse worlds- eor.'.iiiior.s at the control desi-. In mdlndu il instances 10533. GARNIER, ARLETTt. (Comm. Energ. Atom., Fontcny-AuxRoses, Fr.) Evaluation det doses d'irradiation interne deUvrees aux lndlvldus du public par suite de la pollution des aliments par le 0Sr et I* 137ce, en vue de la determination des niveaux de rejet des radioruclid-s dans le milieu ammanl. (Evaluation oi thy internal r--v.a- f 3 ( these factors teno to Increase the tick-rate among the uporaiors. non duscs undergone cv the general i--lu. a r . 3 ,c. - v . --J. F. L. id; t-ullution oi moo and determination -I Jiv l-'.eii : 10526. KRYZHANOVSKI1, N. V. Gigienicheside uslovtva pri zachlstke di5crarce mio the environment. > HEALTH PHYS 22(3): ic-'-J-.r Ulus. 19.2. (tngL summ.|--This study is aimed at the investigation neftenalivnykh sudov i tkh vlivanie na zdorov'e rabochikn* frivgienic conditions in cleaning oil tankers and their effect on the wot nrrs' health. I GIG TR Pr6f ZABOL 15,'3F 14-17. 1671. lEncL aiimm.l -When cleaning oil tankers the hydrocarbons in the air exceed the of models for the determination of levels of discharge of radioactive substances Into the environment. For this jmrpose. It is proposed to estimate the average internal radiation dose resulting from contamina tion of the food-chain by So5r and 13'Cs, taking into account the condi maximum permissible concentration m 54.3*7 of eases handling crude tions and transfer mechanisms of the environment, the various links oil sod In 64,1% of cases dealing with diesel oil. The hydrocarbon in the food-chain, and the characteristics of the population groups con- OLI 4971 AUDIjOiMi, EviTRjJY. /J *LEaArRy,oioUltDUDtoLl.f9i/?:'aEdA5.-R-*71,g, Apr tj MIDDLE, pathology/ FEMALE/ FOREIGN BODIES/ FOREIGN BODY REACTION/ GRANULOMA, etiology/ GRANULOMA, pathology/ HUMAN/ MIDDLE AGE/ POLYTETRAFLUOftOETRYLENE, adveiu ertecti/ PROSTHESIS, adveru elfccti/ STAPES SURGERY, adveru effect*/ STARCH, adww effect* )?IL The use of Teflon la arterUt SuTgety. Boyd DP* el tl. Sarg CUn North Am 53:311-4. Apr ft AORTA. ABDOMINAL, surgery/ *BLOOD VESSEL PROSTHESIS/ BLOOD VESSEL PROSTHESIS, adverse effect*/ COMPARATIVE STUDY/ EVALUATION STUDIES/ FOLLOW-UP STUDIES/ HUMAN/ ILIAC ARTERY, surgery/ POLYETHYLENE TER2PHTHALATE/ POLYTETRAFLUOROETHYLENE/ POLYTETIlAFLUOItOETHYLENE, adverse effect*/ POSTOPERATIVE COMPLICATIONS POISONING 3743. Pulmonary edema after Inhalation of fume* tram polylo trailuoroctbyleoe {PTFEJ. Snu KA. J Otcep Had 15:59H0), Jul 73 ENVIRONMENTAL EXPOSURE/ HEAT/ HUMAN/ MALE/ MIDDLE AGE/ OCCUPATIONAL DISEASES, chemically Induced/ OCCUPATIONAL DISEASES* radlosraphy/ POLYTETRAFLUOROETHYLENE, poisoning/ PULMONARY EDEMA, chemically induced/ PULMONARY EDEMA, radiography POLYVINYLPYRROLIDONE ADVERSE E7FECT3 3744- Reaction to povtdone-lodtne surgical scrub aaaodaled with radical pelvic operation*, Lloreaa AS. Ad 9 Qbitet Ojaeeol 114.334-3. 13 Nov 71 ADULT/ CERVIX NEOPLASMS, surgery/ DERMATITIS, CONTACT, etiology/ DERMATITIS, CONTACT, prevention A control/ FEMALE/ .HUMAN/ HYSTERECTOMY/ LYMPH NODE EXCISION/ POLYVINYLPYRROLIDONE, adverse effect*/ POVIDONE-IODINE, advene effect*/ PREOPERATIVE CARE/ SKIN/ STERILIZATION POLYVINYLS ADVERSE EFFECTS 3T-SS. Plasticizer* In tuunao tissues. Rubin KJ, et el. H Ea;l 9 tied 138:915-8, 33 Apr 73 BLOOD PRESERVATION, Instrumentation/ BLOOD TRANSFUSION, Instrumentation/ HUMAN/ PHTHAL1C ACID, metabolism/ POLYVINYLS, adverse effect* TOXICITY 3743. |Occupational polyvinylI c acropatby] Dugola P, et al. Boll floe Fr Dermatol SypUllyr 73:137-3, 1373 <Fre1 ADULT/ *DONB DISEASES, chemically Induced/ CASE REPORT/ EDEMA, chemically Induced/ `FINGERS/ *HAND DERMATOSES, chemically Induced/ HUMAN/ MALE/ OCCUPATIONAL DISEASES/ OSTEOARTHROPATHY, SECONDARY HYPERTROPHIC/ 'POLYVINYLS, toxicity/ ISnCduLEceRdODERMA, SYSTEMIC, chemically 3747. Wider application of prolonged nasotracheal Intubation. Boa CE, el al. Cl/ratattoa 4/.J i --* - *J _ ACID-BASE EQUILIBRIUM/ ARRHYTHMIA, drug therapy/ ARRHYTHMIA, etiology/ HEART ARREST, chemically Induced/ HUMAN/ HYPOKALEMIA, drug therapy/ POTASSIUM, administration A dosage/ POTASSIUM, adverse effect*/ POTASSU/M, metaboltam/ POTASSIUM DEFICIENCY, complications/ 'POTASSIUM DEFICIENCY, drug therapy J749. Chromium-amino add conjugates *a elldtora in chromium-sensitized guinea plga. Shmunea E, el al, j invest Dermatol 30:193-3, Apr 73 AMINO ACIDS/ ANIMAL EXPERIMENTS/ ANTIGENS/ CHEMISTRY/ 'CHROMIUM, adverse effect*/ 'DERMATITIS, CONTACT, etiology/ DRUG HYPERSENSITIVITY/ GUINEA PIGS/ INJECTIONS. SUBCUTANEOUS/ METHODS/ POTASSIUM, adverse effect!/ SKIN, drug effects/ SKIN TESTS 3750. | Effect of salt dust on the mucous membrane of the upper respiratory tract (a rabbits] Frey HH, et al. r.lenatsschr ObrenbeUkd Laryngorhlnol 197:3-13, Jan 73 (Eng. Abatr.) (Get) ANIMAL EXPERIMENTS/ CALCIUM, adverse effect*/ *DUST/ ENGLISH ABSTRACT/ ENVIRONMENTAL EXPOSURE/ INDUSTRIAL MEDICINE/ MAGNESIUM, adverse effect*/ MUCOUS MEMBRANE, drug effects/ NASAL MUCOSA/ POTASSIUM, adverse effects/ RABBITS/ 'RESPIRATORY SYSTEM/ RESPIRATORY TRACT DISEASES, etiology/ SODIUM, adverse effects 3751. Drug therapy for cardiac arrhythmia*. Chung EX. Postgrad Med 53:107-14, Apr 73 ARRHYTHMIA, drug therapy/ ATROPINE, adverse effects/ ATROPINE* therapeutic use/ BRETYLIUM COMPOUNDS, adverse effects/ BRETYUUM COMPOUNDS, therapeutic use/ DIGITALIS GLYCOSIDES, adverse effect*/ DIGITALIS GLYCOSIDES, therapeutic use/ DIPHENYLHYOANTOrN, adverse effect*/ DIPHENYLUYDANTOIN, therapeutic use/ EPINEPHRINE; adverse effect*/ EPINEPHRINE, therapeutic use/ HUMAN/ ISOPROTERENOL, adverse effects/ ISOPROTERENOL, therapeutic u*a/ LIDOCAJNE, adverae effect*/ UDOCAINE. therapeutic use/ 'MYOCARDIAL DEPRESSANTS, therapeutic use/ POTASSIUM, adverae effects/ POTASSIUM, therapeutic use/ PROCAINE AMIDE, adverse effect*/ PROCAINE AMIDE, therapeutic use/ PROPRANOLOL, adverse effects/ PROPRANOLOL, therapeutic ate/ QUISIDINB, POISONING 3753. |Caustic burns of tha esophagus In African children) Durcnne JM. et *L Ana Soc Del* Me* Trap 31:433-503,1373 (Eng. Abatr.) (frit ACCIDENTS, HOME, prevention A control/ BURNS. CHEMICAL/ BURNS, CHEMICAL, complications/ BURNS, CHEMICAL, diagnosis/ CHILD/ CHILD, PRESCHOOL/ DILATATION/ ENGLISH ABSTRACT/ ESOPHAGEAL STENOSIS, etiology/ ESOPHAGEAL STENOSIS, therapy/ 'ESOPHAGUS, tajurle*/ FEMALE/ HUMAN/ IVORY COAST/ POTASSIUM, poisoning 3753. I Acute fatal bichromate polaonlng] Schlatter C, et al. Beltr Ocrlcbll tied 30:333-8.1373 (Eng. Abatr.) (Ger) ACUTE DISEASE/ CHROMATES, metabolism/ CHROMATESv, npoitisiConfinga/rUENAGfilL.OISBHIN/ k jrJ* * 3755. [Animal experiment model* t.t c** ensltUatloo polcnc/ of dre* Demonstration of cc^RLLillo:) !*r dlchramateuoJrr variola c'.dJi:. -j Dcrmslol blooati&chr laj ' ANIMAL EXPERIMENTS' *Ciinf toxicity/ DISEASE UODHA A1. HYPERSENSITIVITY/ 'ECZEMA Induced/ ECZEMA. pat*::/'j. ABSTRACT/ GUINEA Plf,? UA POTASSIUM, toilclly *r TIME FACTORS POTASSIUM CHLORIDE ADVERSE EFFECTS 3759. Gaalrtc ulcers due to ?7.e tniaXe f , Jacob* E, et al J Dlj l i . ADULT' CORONARY rj;iES:r FEMALE HU?!\N II AL" i therapy/ POTAsSiLIf C..L '.i.` administration A taugr r CHLORIDE. aJ.ene lfcc i r( CHLORIDE, Jlajsorlc .! >. CHLORIDE, tberapeu. c .> - ULCER, chem9ca.ly IrJ-ce: ULCER, radtofraph* TAS-iT- ENTEitlC-CO A TED 3757. Potassium overdoaaae Jp.'.r..a \t parcotcnl fluid - Dr Med J 1 7' 1-5 21 liar ' ADULT/ FEMALE IiV'1 AN I!YPEltXALEHIA, 4- PARENTERAL, adverse .f-: * PARENTERAL, Itstnsex'j: r PLASTICS/ POTASSIl'J .... administration St fcuje *? CHLORIDE, ad-er*e effeej 3759, Mortality of pois-ii * '*i *- 9 Occup Med .Z5-. ACCIDENT ?rvIVi sT*}N mortality/ EPIDEMICLC " HEART DISEASES, cm -* INDUSTRIAL -VAST: _ .. compUcxtloss LUNG LUNG DISEASES, - ' NEOPLASMS. - new iiE.iic^ :tct :j . . etiology' OCCU?\-r-s ' tnorlali:/' * s; L - *** PNEUMONIA* CIILCRIDS, - C:iLOU:DE, i-wr iK . I PULSION At* V, a.;- POTASSIUM PERM AN G A. * V * \ POISONING 3759. PoCaxJlumpcrmaiaaia.t- 7 -' et *1 Eye Ear Scte TL'-i. ti: ADULT/ JJL'TNC C:E*J.**4` chemically ..'.Cvi u poTASi*u'd pym is.iv 3710. [Case report* of drug F ~ :4 F*rm Zh 27 63-7J. 1?7S . :j AS'TiDt.Tr :'RL<; t\Qu:.:i --iM-.cr . 1 1'OTASsll M I'f ' SALiCVLIC polaonlng 4 OLI 4972 nduced/ FEMALE/ /INTWTINAL, drug CSTINAL dy induced/ `KIDNEY RlcalUma/ KIDNEY J ib*'rapy/ tlALE/ nilAGK, ill1'NITS, ndverse >, ihorapeullc use/ therapy/ SULFONIC SIX* ONIC ACIDS, LENE a of the oval window. 1 C: 1 -7 255-78, Apr TJ !.\l.l ' `FOREIGN <v s;::action/ GRANULOMA, BOLE AGE/ .IY!.:\VE, adverse ivn,o effects/ versu b.ifecta/ * surgery. Boyd DP. et al. 331-4. Apr 73 rjr?,-y' `BLOOD 'LOUD VESSEL era/ COMPARATIVE STUDIES/ :;u:i\n/ iliac , :thylene njyj.ENE/ :iY! NI2, adverse L COMPLICATIONS -ii of fumes from ' i KJ-: y Evans LA. J.;l 73 0 HUE/ HEAT/ !. m;e/ V- . chcruU-lly 41 . .LEASES, *.,-i ::NE, poisoning/ r.nlcally induced/ .phy DEBUGS AND .HEwllCALS POTASSIUM J Laryngol Otol 87:283-73, Mar 73 ADOLESCENCE/ ADULT/ AGED/ CELLS, CULTURED/ CHILD/ CHILD. PRESCHOOL/ FEMALE/ HUMAN/ HUMIDITY/ INFANT/ INTUBATION, INTRATRACHEAL/ INTUBATION, INTRATRACHEAL, adverse V effects/ LARYNGITIS, therapy/ LARYNX, surgery/ LUBRICATION/ MALE/ METHODS/ MIDDLE AGE/ POLYVINYLS/ POLYVINYLS, toxicity/ POSTOPERATIVE CARE/ SILICONES/ SODIUM CHLORIDE POTASSIUM ADVERSE EFFECTS 3748. Dilemmas in potassium therapy. Burchett HB. Circulation 47:1144-5, Juo 73 ACID-BASE EQUILIBRIUM/ ARRHYTHMIA, drug therapy/ `ARRHYTHMIA, etiology/ HEART ARREST, chemically Induced/ HUMAN/ HYPOKALEMIA, drug therapy/ POTASSIUM, administration & dosage/ POTASSIUM, adverse effects/ POTASSIUM, metabolism/ POTASSIUM DEFICIENCY, complication*/ `POTASSIUM DEFICIENCY, drug therapy 3749. Chromium-amino add conjugates a* shelters In cbromlum-senaltlzed guinea pig*- Shmuaes E, et ai. J latest Dermatol 80:193-5. Apr 73 AMINO ACIDS/ ANIMAL EXPERIMENTS/ ANTIGENS/ CHEMISTRY/ `CHROMIUM, adverse effect*/ `DERMATITIS, CONTACT, etiology/ DRUG HYPERSENSITIVITY/ GUINEA PIGS/ INJECTIONS, SUBCUTANEOUS/ METHODS/ POTASSIUM, adverse effect*/ SKIN, drug effects/ SKIN TESTS 3750. (Effect of salt dust on the mucous membrane of the upper respiratory tract la rabbits] Frey Hit. et al. Mosatsschr Obrenhellkd Laryngorhlnol 187.8-18, Jan 73 (Eng. Abetr.J (Qer) ANIMAL EXPERIMENTS/ CALCIUM, adverse effect*/ `DUST/ ENGLISH ABSTRACT/ ENVIRONMENTAL EXPOSURE/ INDUSTRIAL MEDICINE/ MAGNESIUM, adverse effects/ MUCOUS MEMBRANE, drug efrects/ NASAL MUCOSA/ POTASSIUM, adverse effects/ RABBITS/ `RESPIRATORY SYSTEM/ RESPIRATORY TRACT DISEASES, etiology/ SODIUM, adverse effects 3751. Drug therapy for cardiac arrhythmias. Chung EK. Postered Med 53:107-14, Apr 73. ARRHYTHMIA, drug therapy/ ATHOP1NK. adverse effect*/ ATROPINE, therapeutic use/ BRETYUUM COMPOUNDS, adverse effect*/^, BRETYLIUM COMPOUNDS, therapeutic us^H ........... M'T^iriFS, adverse effecls/^H HUMAN/ MIDDLE AGE/ POISONING, pathology/ POTASSIUM. poisoning/ SUICIDE TOXICITY I7Si [Activation or renal potassium cDmkiullon and reduettoa of potassium UtlcUir through repealed loading with KC1 solution In rats of various ages I Puschmano H. el al. AeU Biol tied Qe* 28:877-87,1973 fCng- Absir ) (G er> AGE FACTORSt ANIMAL EXPERIMENTS ENGLISH ABSTRACT/ FEMALE/ KIDNEY TUBULES, drug effects/ `KIDNEY TUBULES, metabolism/ KIDNEY TUBULES, secretionMALE/ *POTASSIUM, metabolism/ POTASSIUM, pharmacodynamics/ POTASSIUM, secretion/ POTASSIUM, toxicity/ POTASSIUM, urine/ POTASSIUM CHLORIDE. aeUbolirmPOTASSIUM CHLORIDE, pharmacodynamic* RATS 3755. (Animal experiment models for demonstration of sensitization potency of drug combination*. I. Demonstration of sensitization potency of potass ium Bichromate under various conditions| Loechel 1. el al. Dermatol Ututiulr 159:222-6,Usr 73 (Eng. Abitr.) {Ger} ANIMAL EXPERIMENTS/ `CHROMATES, toxicity/ DISEASE MODELS, ANIMAL/ `DRUG HYPERSENSITIVITY/ `ECZEMA. chemically Induced/ ECZEMA, pathology/ ENGLISH ABSTRACT/ GUINEA PIGS/ MALE/ `POTASSIUM, toxicity/ SKIN, pathology/ TIMS FACTORS POTASSIUM CHLORIDE ADVERSE EFFECTS SHI, Gastric ulcere due to the Intake of potassium chloride. Jacob* E, el Al. Am I Dig DU 13:239-9*. Apr 73 ADULT/ COnONARY DISEASE diagnosis FEMALE/ HUMAN/ MALE/ OBESITY, drug therapy/ POTASSIUM CHLORIDE, administration & dosage/ `POTASSIUM CHLORIDE, adverse e.'foct*/ POTASSIUM CHLORIDE, diagnostic use/ POTASSIUM CHLORIDE, therapeutic use/ `STOMACH ULCER, chemically Induced/ STOMACH ULCER, radiography/ TABLETS, ENTERIC-COATED 3757, Potassium overdosage: a potential hazard of non-rigid parenteral fluid containers. Williams SB, Bf Usd J 1:714-5. 34 Mar T3 ADULT/ FEMALE/ HUMAN/ HYPERKALEMIA, etiology/ `INFUSIONS, PARENTERAL, adverse effect*/ INFUSIONS. PARENTERAL. instrumentation/ UAX.Es PLASTICS/ POTASSIUM CHLORIDE, administration 4t dosage/ `POTASSIUM CHLORIDE, adverse effect* O LI 4973 DIVUGS AND CHUMS CALS i*ui:iMs()i.oNr, IM-UMAUll4'. CON I\MT. et lolngv , K7I'.MA. rll.,|..gv | M,|,I..U ARNIRAUT' HM.KltS, injimos III1 PA 111 Is, TO\K', elMnj;> 7 HI M \\ ViU'l! IIIAM1`NUN. adverse efferls' Ot Ul PATIONAL DERMATITIS, Chemically induced `PLASTICS, adverse effects POLYMERS, adverse effects/ POLYVlNYI-S, .nKer.se effeels' PRURITUS, chemically niliiccU/ KAVNAIID'N DISEASE. rliemlr.illy iiuluteil llt.MN.S, .nitiT.'' effeelK/ `SKIN l)|s|. \SKN, chemically Induced/ NliIN 'JESTS 3525 An evaluation of pnlyclcrtrolyto complexes As biotnedicjl materials Marshall I'W, cl *1. .1 P.mwrd Mater lies 4'357'Gh, Sep 70 AMVAI. EXPERIMENTS/ BIODEGRADATION/ LIIOMKCHANICS/ EQUIPMENT AND SUPPLIES' *MKVHRANKS, ARTIFICIAL/ POLYMERS, adverse effects/ POLYSTYRENES. adverse effects/ POLYVINYLS, adverse effects/ `PROSTHESIS, standards/ RABBITS/ RATS/ STERILIZATION/ 'THROMBOSIS, -chemically induced POTASSIUM adverse effects 3526. Reversion of atrial fibrillation following hyperkalemia Manchester JH, ei al Chest 58:399-402. Oel 7U ACUTE DISEASE/ ARRHYTHMIA, SINUS, chemically induced/ * AURICULAR FIBRILLATION. complications/ AURICULAR FIBRILLATION, therapy/ ELECTROCARDIOGRAPHY/ GLUCOSE, therapeutic use/ HEART ATRIUM, phytopathology/ HEART CONDUCTION SYSTEM, physlfMialhology/ HUMAN/ *flYPKHKALEMfA, complications/ U\I'KKKALKMIA, therapy/ INSULIN, therapeutic use/ M1DD1.K AGE/ PACEMAKER,. ARTIFICIAL/ POTASSIUM, adverse effect*/ POTASSIUM, therapeutic use/ SODIUM, therapeutic use 3527 Potassium therapy and gn.struinicstinal lesions. Emerson UN, Nrbr Stair Med J 55.518-23, Sep 7(1 ANIMAL EXPERIMENTS/ DIURETICS, therapeutic use/ DRUG AND NARCOTIC CON'IROL/ HUMAN/ `INTESTINAL DISEASES, chemically induced/ `INTESTINAL OR.YMtUl.TION, chemically Indued/ INTESTINE, SMALL, .drug effects/ POTASSIUM, advert* effect*/ POTASSIUM CHLORIDE, adverse effects/ ULCER, chemically Induced POISONING 352ft. |A fatal cane of poLas.dum chlorate poisoning) Fukumoto K, cl al Jap J Leg Med 24.242-G, May 70 (Jap) AGED/ AUTOPSY/ `CATHARTICS, polaonlUfi/ ENGLISH ABSTRACT/ FEMALE/ HUMAN/ `PERCHLORIC ACIDS, poisoning/ POISONING, pathology/ `POTASSIUM, poUvnlng TOXICITY 3529. Potassium and arrhythmias. Davis R1I, ct al. Geriatric* 25TOTIC*. Nov 70 ADMINISTRATION. ORAL/ ARRHYTHMIA, drug therapy/ ELECTROCARDIOGRAPHY/ HEART ULOCK/ HEART CONDUCTION SYSTEM, drug effects/ HUMAN/ HYPERKALEMIA/ INJECTIONS. intravenous/ kidney FAILURE. ACUTE/ PACEMAKER. ARTIFICIAL/ `POTASSIUM. admluKirallon dosage/ POTASSIUM. InxR dy potassium <:iii.okii>i-: ADVERSE EFFECTS 3539, Jf.aMric perforation duo to pot.:,,..'>mni chioroif prR.>| AouMlii J. rt al (`tnriiigir ho |i2 3, I`,l7u (Erel ADM1MS1 HA'I ION ORAL '.<.1:10 HUMAN MALE' PO'IANSII M cm.niOl'l.. ammidMrdiion a di> uge< *Pt> rxiiw CHLORIDE. adverse effect `STOMACH RUPTURE, chemical*} induced 3531. (Stenosis arid Inlcs0n.il pet (oratlm) after absorption of potassium chlurl<ie| Uhkttc P. et al Coeur Med Iputih* 8 4nj 7. Jul uP (Em `HEART DISEASE**. drug theiapy ' HOMAN pl NTFSTIN'AI. * iRNTKUC I'fON. chemically Induced MS' I'E-S I'lNAt. l'ERS ORATION, chemically Induced MALE/ MIDDLE AGE' `PEP I If ULCER n.I.KdllATHlN, chemically Imlueril/ 'I'OIASMIIM CHLORIDE, adverse effects 3332. Potassium therapy and gaMrt>iuic..ilnal lesions. Emerson DN Nebr State Med J 55,518-23. Sep 70 ANIMAL EXPERIMENTS/ DlGItKJ'lCS. therapeutic uv*/ DRUG AND NARCOTIC CONTROL/ HUMAN/ `JNTESJ INAI. DISEASES, chemically / `INTESTINAL OUST'RUCTION, chemically imiuicd/ INTESTINE, SMALL, drug effects/ POTASSIUM, adverse effects/ POTASSIUM CHLORIDE, adverse effect*/ U1ATER, chemically induced POTASSIUM PEKMANOANATK ADVERSE EFFECTS 3533. (Vaginal burn* by caustic substance*. A ttoclo-mcdlcal problem] Zdrate Sandoval II, ct al. Glaccol Obstel Me* 27:559-67, Hay 70 (Spa) ABORTION, CRIMINAL/ ADOLESCENCE/ ADULT/ `BURNS, CHEMICAL/ `CAUSTICS, adverse effects/ ENGLISH ABSTRACT/ FEMALE/ HUMAN/ `POTASSIUM PERMANGANATE, adverse effects/ Pregnancy/ pregnancy COMPLICATIONS, chemically Induced/ SOCIOECONOMIC FACTORS/ `VAGINAL DISEASES, ehemically induced POISONING 3534. (Attempt at nbortion with potassium permanganate tablets] Le Cos A, et al. Dull Fed Sue Gynecol Obsict Lang Fr 20:190-1, Apr-May Ch (Fre) ABORTION. CRIMINAL/ FEMALE/ HUMAN/ POTASSIUM PERMANGANATE, poisoning/ PREGNANCY/ TABLETS PKALIDOXIME COMPOUNDS TOXICITY 3535 Resistance to various pesticides induced by catatoxlc steroids Kelye H Arch Kuvliou llralth 21:709-10. Dec 7t) ADMINISTRATION, ORAL/ ANABOLIC STEROIDS, pliatuuiciMlyii.iitilr:./ ANIMAL EXPERIMENTS/ lm'. G.xlclty/ DKSOXYCOKTlCOSTEltONE. pharmacodynamics/ ESTRADIOL, pharmacodynamic*/ KTUYLKSTKKNOL. pharmacodynamics/ FEMALE/ INSEC'I ICIDES, antagonist* A inhibitors/ `INSECTICIDES, toxicity/ OXANDltOLONK, pharmacodynamic*/ PAUATHION, toxicity/ PHOSPHORIC ACIDS, antagonists At Inhibitors/ `PHOSPHORIC ACIDS, toxicity/ PlIYNOSTIGMINK, toxicity/ PRALIDOX1MK COMPOUNDS, toxicity/ PREDNISOLONE, pharmacodynamics/ PREGNANKDIOL. pharmacodynamic*/ PREGNANES, pharmacodynamics/ PROGESTERONE, pharmacodynamic*/ RATS/ SPIRONOLACTONE, pharmarodynanilci/ `STEROIDS, pharmacodynamic*/ THYROXINE, pharmacodynamic*/ TRIAMCINOLONE, pliariiiacodynamic* 3539- | llcpatoloxlelly of nitrostlgnilin* ih 693 forte) and obldoximc (Toxoit*nin) tn dogiil Boelcke G, et al. Aren Tnxihol 2G 93-101. Iu70 (Gerl ALANINE AMINOTRANSFERASE, hlood/ AN1MAI. EXPERIMENTS/ ANTIDOTES/ ASPARTATE AMINOTRANSFERASE, lilood/ ATROPINE, thct.ipcuOc CIIOI.INKS! ERASE. bhn.il' DOGS ENGLISH ABSTRACT' HtV I IlKOUV l I N. r< vi`..loi:> I-I MAM. I.AU1ATK ll.11 \ OlttH.I NAsK, lilootl `LIVI-R. dim: Hlcl. MAM* I'ARA I IIION, toxtclly `PR .\|,|lm\lMK COMPOl NDS, l.ixleity/ M CCINATE DEHYDROGENASE, blod nCKDMSOLONK ADVERSE EFFECTS 3537 Vascutas compIlcuUoti*. In ni'phrolii1 h>fidroiiurelationship to kloroht ihcrj|> *nd ai-i'elerated ihrionboplavtlu generation Mukherjce At', ct al. Ur Mrd J 4 273 9. 31 OH 7H ADULT. IH.OOD CK1.I. COUNT R1 OOD COAGULATION HISTS' lll.OOD PI,A`I El.ETS< 'HOLES'/ EROL. Woml ' PKMAV> HEPARIN. OM-rjpeulIc use HUMAN MAM NEPHROTIU SYNDROME, eomplhations OLI 4974 VINYL COMPOUNDS DRUGS AND HSCfUCALS VINYL COMPOUNDS POISONING 4S20. {Characteristic# of the state of them*] regulation Id chronic vinyl chloride Intoxication] Stulova EA. oif Tr Prof Zafcoi 17:53-5, Mar 7$ (Ro*> ADULT/ "BODY TEMPERATURE REGULATION, drug effect!/ CHRONIC DISEASE/ FEMALE/ FEVER, chemically Induced/ HUMAN/ MALE/ MIDDLE AGE/ VINYL COMPOUNDS, poltonlog TOXICITY 4321. [ A&ttneoplaatlc effect of vtnytaulionea aad their pccilble predecesaora) Pol'klna HI, et at. Vopr Oaltol 19.02-3, lOTAMEog. Abatr 1 (Rut) DOSE-RESPONSE RELATIONSHIP, DRUG/ ENGLISH ABSTRACT/ MICE/ NEOPLASM TRANSPLANTATION/ `NEOPLASMS, mEXPnEfRliIMilENtfTf AL, drug therapy/ RATS/ CROCKER, drug therapy/ STRUCTURE-ACTIVITY RELATIONSHIP/ SULFONES, therapeutic uae/ SULFONES. toxicity/ `VINYL COMPOUNDS, therapeutic use/ VINYL COMPOUNDS, toxicity VIRAL VACCINES ADVERSE EFFECTS 4821. Harards of vaccination In pregnancy. Drag Tber Dull 11:13-5, 14 Feb 73 FEMALE/ FETAL DISEASES, ellokgy/ FETUS, drug effect*/ HUMAN/ PREGNANCY/ RUBELLA VACCINE, advene effect!/ SMALLPOX VACCINE, advene effect*/ `VACCINATION, adverse effect!/ VACCINIA, etiology/ VIRAL VACCINES, advene effect* 4023. (Effect of foot-and-mouth disease vaccination on white Llood ceil* In cattle] Boler D et al. Monaub Vet Med 23:254-6, I Apr 33 (Eaf. Abatr > (Gen ANIMAL EXPERIMENTS CATTLE/ `CATTLE DISEASES, prevention it control/ ENGLISH ABSTRACT/ FOOT-AND-MOUTH DISEASE, prevention A control/ `FOOT-AND-MOUTH DISEASE, veterinary' LEUKOCYTE COUNT, voterlairy/ VIRAL VACCINES, adverse effect!/ VIRAL VACCINES, therapeutic uae 4324. I Uffcct of atHnuatrd hog chutera virus vaccine from the Inoculation vlrua atraln "C" on pregnant sow* and their progeny] Tenner S, et at. Monaub Vet Med 28:251 4. ] Apr 73 (Kng A bur j INFECTIONS, veterinary/ `POULTRY DISEASES, prevention 6c control/ `VIRAL VACCINES, advert* effect* 4620. [Camel pox caused by pox vaccine (detritus)} Krupeoko SS. Vcterlaarlla 6:61-2, Aug 73 (3oi> ANIMAL EXPERIMENTS/ `CAMELS/ POXVIRUS INFECTIONS, etiology/ POXVIRUS INFECTIONS, prevention 6t control/ `POXVIRUS INFECTIONS, veterinary/ VACCINATION/ `VIRAL VACCINES, adverse effects VITAMIN A ADVERSE EFFECTS 4620. Urea and retinoic add in Ichthyosis and their effect on tramepideroal water loss and water bolding capacity of stratum corneum. Grice K. ct al. Aeu Derm Veaereol (Giochh) $3:114-3, 1913 ADOLESCENCE/ ADULT/ AUTOSOUE ABNORMALITIES/ CHILD/ FEMALE/ HUMAN/ `ICHTHYOSIS, drug tfaempy/ KERATOSIS, drug therapy/ MALE/ MIDDLE AGE/ SEX CHROMOSOME ABNORMALITIES/ SKIN. caeUboUern/ `SWEATING/ `UREA, therapeutic nee/ VITAMIN A, adverse effect*-' `VITAMIN A. therapeutic use/ WATER LOSS. INSENSIBLE, drug effect* 4630. Acute hypervltamlnofll* A la an adult. Furman Kf. Am g CU* Nntr 23:575-7, Jaa 73 ACUTE DISEASE/ ADULT/ AFRICA, SOUTHERN/ DERMATITIS, etiology/ DRUGS, NON-PRESCRIPTION/ FEMALE/ HEADACHE, etiology/ HUMAN/ NAUSEA, etiology/ PAPILLEDEMA, etiology/ SELF MEDICATION/ `SUNBURN, drug therapy/ SUNBURN, prevention A control/ VISION DISORDERS, etiology/ VITAMIN A. administration A dosage/ `VITAMIN A, tdverae effects/ VITAMIN A, blood/ VITAMIN A. therapeutic uae/ VOMITING, etiology 4631. Induction by dimethylbydraxlne of Intestinal carcinoma la normal rata and rata fed high or low level* of vitamin A Roger* AE, el al. Cancer Rea 33:1003-9, May 73 ADENOCARCINOMA, chemically Induced/ ANIMAL EXPERIMENTS/ DIET/ DRUG INTERACTIONS/ `HYDRAZINES/ HYDRAZINES, administration A dosage/ INTESTINAL MUCOSA/ `INTESTINAL NEOPLASMS, chemically Induced/ 1 i'ESTJ.N AL NEOPLASMS, complication*/ L:*'IPS, metabolism/ LIVER, metabolism/ UALK/ NEOPLASM METASTASIS/ RATS/ IIATS, INBRED STRAINS/ TIME FACTORS' VITA:,US A ** TOXICITY 4935. IlyrarvJiamln-s.a A - * k different forr % 1 * j Lcciapr-.e V, , i \i-i ANT'. \L Sl'uiO?,?TiO* r CALCi'iG ! v . - . iflDMY, i-*.i : * LUNG, ,!!' M , effect*' `0-:;-;; RATS' ViTWL'. t VITAMIN A, :.t.. y 4033. effect of hyper- i*-* * cortlcoitercjil* s ladlas J G.c:'* * iiO;i:;G\LS .. *v drug effect* A. . t: metabolism* K .I'1 * t ascorbic mriaboRsm' r. *! i. LIVER CLVi.. - STJMULA1K * io*(cU' VITAMIN It COMIM r \ adverse rrrccTs 637. 'fts.lor-! ci! c:i * -. ::en:s :i : J Am ' * 5srr> \r/.......... ,'ul -.kSj ACID, Ibrn? ' effee'* ru - \ SYNERGISM j PSYcm vrn:: :: ART tbcra^i ,,J.,. M \* i * j ORGANIC. - StS'lLL. drug :* druj rrrapv offer:* '1IJI . Si S0 %-mV VITAMIN H ADVERSE tTFLCTS 4623. VID , e,-t7 ; .`A1 , - * >, aga.- i.-; , \.tu> Ini scei w MLT.V.s , r4u O LI 4975 DRUGS AND CMER1ICALS POLYVINYLS 1*01,1 MKKS POI.YTIIUZJDK XL AUVr.KSH HPtKCTh AUVEHSK KFFKCTB 3381, incrmatojirs. canard by melamine*) Koubrlrr It. n nl. Arch M.H Prot 33 202-4, Apr-M-iy ?2 (Pre) envjkonmkntal exposure/ female/ HUMAN/ 'OCCUPATIONAL UKUMATITIS/ POLYMKItS. advrrar rf/rcU/ MUN TESTS 3383. The effect of a ayntheUc anionic polymer (pyran) on the development of foot-and-mouth dlseace in gulnca-plgs, cattle and pig*. Seller* RF, et al. Ret Vet SO 13.338-4), Jul 72 ANIMAL EXPERIMENTS/ BODY WEIGHT, drug effect*/ CATTLE,/ CATTLE DISEASES, prevention A control/ 'FOOT-AND-MOUTH DISEASE, prevention A control/ GUINEA PICS/ INJECTIONS. INTKAPKtltTONEALf INTEKFEKON, analysis/ JNTEHKKKON INDUCERS, therapeutic u*e/ 'MALKATgS. therapeutic use/ PERITONEAL DISEASES, chemically induced/ POLYMERS, adverse effects/ 'POLYVINYLS, therapeutic use/ SWINE/ SWINE DISEASES, prevention A control 3383. [Health bates for standards for school bullying* mad equipment) Korenevtkaia El. Vesta Akad Med Nank SS5R 37:29-33, 1972 (Rma) ADOLESCENCE/ 'ARCHITECTURE/ CHILD/" CONSTRUCTION MATERIALS, adverse effect*/ ENVIRONMENTAL EXPOSURE/ ENVIRONMENTAL HEALTH/ BEATING/ HUMAN/ LIGHTING/ POLYMERS, adverse effect*/ 'SCHOOL HEALTH/ USSR 3314. (Relapse prevention of the aUerftc abo# ecisna) Kalkoff KW. Z Hast GeteblcChtskr 47:593*4, fl Jul 73 (Oev> DERMATITIS, CONTACT, etiology/ , 'DERMATITIS. CONTACT, prevention A / control/ FEMALE/ FOOT DERMATOSES, chemically induced/ 'FOOT DERMATOSES, prevention A control/ HISTOCOMPATIBILITY TESTING/ HUMAN/ METHODS/ POLYMERS, adverse effect*/ PROTECTIVE DEVICES/ RECURRENCE/ 'SHOES, adverse effect* POLYMYXIN ADVERSE EFFECTS IMS. HnUlil **pala lv the fur.leal patient. Rlrbarda Kt, ( aL Sara CUn No,lit Am 32;13M-4M, Pec 72 adolescence/ adult/ aged/ AMPICILLIN, advene effecta/ BODY TEMPERATURE/ -BURNS, complication!/ BURNS. microbloio.y/ CANDIDA ALBICANS, laolatlon A purification/ CARBENICILUN, advar*. .ffecte/ CATHETERIZATION. edvera. effect!/ CHILD/ CHILD. PRESCHOOL/ CHLORAMPHENICOL. advert* .fleet./ DRUG RESISTANCE. MICROBIAL/ ERYTHROMYCIN, adeem affecte/ rEM ALE/ GENTAMICIN, *dv*m .fleet*/ HUMAN/ INFANT/ KANAMYCIN. advert. Bff.ni/ MALE/ KIDDLE AGE/ -MONILIASIS, .tlolefy/ MONILIASIS. mlcrobtolnfy/ MONILIASIS, Bids*/ NASOPHARYNX, microbiology' PENICILLIN, advert. ffU/ POLYMYXIN. \ IdWH (ffccu/ -SEPTICEMIA, etiolo.y/ -SURGERY, OPERATIVE/ TETRACYCLINE, advert. .fleet*/ URINARY CATHETERIZATION, adven. affect*/ WOUND INPECTION, mleroblolofy POLYSACCHARIDES 3387. Propranolol and polythiaalde in treatment ef hypertension. O'Brien ET. et al. llr Itnrt i 34:1042-4. Oct 72 ADULT/ ULOOD IMtKKSUHK, drug effect*/ BRONCHIAL SPASM, chemically induced/ 'DRUG SYNERGISM/ DRUG WITHDRAWAL SYMPTOMS/ FEMALE/ HALLUCINATIONS, chemically Induced/ HUMAN/ HYPERTENSION, drug therapy/ MALE/ MIDDLE AGE/ NEGROES/ POLYTBlAZIDE, adverse effect*/ 'POLYTIUAZIDE. therapeutic uie/ PROPRANOLOL adverse effects/ PROPRANOLOL, therapeutic use/ PULSE, drug effect*/ RACIAL STOCKS/ SLEEP DISORDERS, chemically induced/ VERTIGO, chemically induced POLYVINYLPYRROLIDONE ADVERBS EFFECTS 2S*S. (HpaiMB.faUc fora of a thcaaurttmotu oauavd by polyvtBylpyrmUdOBt after proloafd traataeat with dalayed^eUoa poit.rlor pituitary pr.par.tlaa] FoaaaU P, at al. Err Fr Eadocrla.l CUa 13:57.41, Ju fib 72 (*a*. Abate.) (Fr.) BIOPSY/ DELAYED-ACTION PREPARATIONS/ DIABETES INSIPIDUS, drug tb.rapy/ ENGLISH ABSTRACT/ -HEPATOMEGALY, ebcmietUy induced/ HUMAN/ INJECTIONS, INTRAMUSCULAR/ -LIVER, metabolism/ LONG TERM CARE/ MALE/ -METABOLIC DISEASES, Chemically Induced/ MIDDLE AGE/ PITUITARY HORMONES. POSTERIOR. admlBlatrattoa 4 douie/ POLYVINYLPYRROLIDONE, admlautnttoa 4 doaaf./ -POLYVINYLPYRROLIDONE, advert* affect*/ POLYVINYLPYRROLIDONE, BtaUbalum/ -VEHICLES, advara* effect*/ VEHICLES, meubalum POLYVINYLS ADVXUC UTICtl 3393. [Scleroderma Uke akin chans**- Raynaud'* syndrom# end screosteolyse* lo workers in the polyvinyl chloride producing Industry) Jube S. et al. Ptaeh Med Wocbeaiehr 97:1922-3, t Dec 72 (G*r> ARM, blood supply/ ARTERIES, radiography/ BONE RESORPTION, chemically Induced/ ENVIRONMENTAL EXPOSURE/ FINGERS/ HUMAN/ MALE/ 'OCCUPATIONAL DISEASES* chemically induced/ POLYVINYLS, adverse effects/ RAYNAUD'S DISEASE* chemically induced/ SCLERODERMA, CIRCUMSCRIBED* chemically Induced A 7. *3*0. Oeeapatlaaal aapKta ef Raynaud'* dt*w*: a erttlnaj blatarleal aurvey. Cbrtatapb.ra AJ. Mad i Aaat 2:720-1, 23 Sep 72 BONE RESORPTION, chemically induced/ COLD/ CONSTRICTION/ FINGERS, bloed aupply/ GERMANY/ GREAT BRITAIN/ HISTORICAL ARTICLE/ HISTORY OF MEDICINE. ISTH CENT./ HISTORY Or MEDICINE, 20TH CENT./ OCCUPATIONAL DISEASES, eUolof,/ OCCUPATIONAL DISEASES, btatery/ POLYVINYLS, adv.ra* BffaCt*/ RAYNAUD'S DISEASE. (Uolofy/ RAYNAUD'S DISEASE, binary/ ROME/ UNITED STATES/ VIBRATION TOXICITY 3384. Antitumor activity of the yeaat maniun preparation in relation to the effret of ehrmteal modification. Oka S, et al. Gan* 93.345-9. Jun 72 ACYLATION/ ADMINISTRATION. ORAL/ ANIMAL EX I'ItUlM F.NTS/ ANTINKOPLA5T1C AGENTS, administration A dosage/ 'ANTINKOPLAST1C AGENTS, therapeutic u*e/ ANTINKOPLASTIC AGENTS, tonicity/ CANDIDA/ COMPARATIVE STUDY/ FEMALE/ HYDROLYSIS/ INJECTIONS. INTRAPElllTONEAl-/ INJECTIONS, INTRAVENOUS/ INJECTIONS, SUBCUTANEOUS/ MALE/ METHYLATION/ MICE/ MOLECULAR WEIGHT/ NEOPLASM TRANSPLANTATION/ POLYSACCHARIhF,S. admleHtnilnn A 'POI.YSACt'ilAlUDr (h<*ra|tt>utic uar/ POLYSACCHAHIDKh. tumidly/ 'SARCOMA 190. CROCKEK, dry* therapy 2l 2l 33*1. The Invletble potlutlan. Hall 1*. ' N Kail J Med 2*7:1145.7. 20 Nov 71 BI.OOD PRESERVATION. tntUumanUllon/ BLOOD TRANSFUSION/ CIIICIUNE/ DISPOSABLE EQUIPMENT/ ENVIRONMENTAL POLLUTION/ HUMAN/ PITTHAL1C ACID, adverae .ffecta/ PIITIIALIC ACID, blood/ PHTHALIC ACID, taetabohan,/ -PLASTICS, adverae .ffecta/ -POLYVINYLS, adverae cffecte/ POLYVINYLS, meUboUam 2M2. I]pataMieM and MNeWnMd ebaaaaa ebaarved la Bvarfaeap4rfwtalp4.amaaninn.il taducM by MBlfl dblaWddl CriMA . Ttaex AYad Med ftlatnev'eYa fUM-IU, 1*72 Ifni A hair ) (Poll ANIMAL E\ PER IM ENTS/ CHt-ORIIlES. adverae .fleet*/ ENGLISH ABSTRACT/ FEMALE/ LIVER, druf effeeta/ -LIVER, pathology/ MALE/ PNEUMOCONIOSIS. A-273 OLI 4976 DRUGS AND CHEMICALS I'l.UTONIUM Jo CATTLE/ CATTLE DISEASES. diagnosis/ CAVN.K DISEASES, i tiil*gy/ IMAGNOMS, liJKtKKKKTIAf./ FEMALE/ IIKIN/ HOlMES/ IIKMA'I 00017 HMIOGLOHIN, jii.iIvnI*/ HKMOUUUAGL. cmiUc,illnn/ HhMOKRH AGK, veterinary/ MALE/ PLANT POISONING, complication*/ PLANT POISONING, veterinary/ TRICJIOSTRONCYLOWIAKIS, Complication*/ TRICHOSTRONGYLOJPIASJS, veterinary 3331. Diseases of too animals In Nigeria. Isouq TT. et al. J Wildl DU 8:335-9. Oct 72 ANIMAL DISEASES, occurrence/ 'ANIMALS, 00/ ARTlODACTYLA/ BABOONS/ BIRD DISEASES, occurrence/ CARNIVORA/ ECHINOCOCCOSIS, veterinary/ ENCEPHALITIS, veterinary/ ENCEPHALOMYELITIS, veterinary/ ESCHERICHIA COLl INFECTIONS, veterinary/ HERPESVIRUS INFECTIONS, veterinary/ MONKEY DISEASES, occurrence/ MUSCULAR DYSTROPHY, veterinary/ NIGERIA/ PERICARDITIS, veterinary/ PLANT POISONING, veterinary/ PRIMATES/ RODENT DISEASES, occurrence/ TRYPANOSOMIASIS, veterinary PLANT PROTEINS ADVERSE EFFECTS Utt. Soy proteln-another caute of the flat Intestinal tealon. Ament ME, et *1. Gastroenterology 62:227*34. Feb 72 ACIDOSIS, etiology/ CYANOSIS, etiology/ DEHYDRATION, etiology/ DIARRHEA, etiology/ FEVER, etiology/ FOOD HYPERSENSITIVITY, complication*/ 'FOOD HYPERSENSITIVITY, etiology/ FOOD HYPERSENSITIVITY, pathology/ HUMAN/ /INFANT/ INFANT FOOD/ INTESTINAL DISEASES, complications/ 'INTESTINAL DISEASES, etiology/ INTESTINAL DISEASES. * pathology/ 'JEJUNUM/ JEJUNUM, pathology/ LEUKOCYTOSIS, etiology/ MALE/ 'PLANT PROTEINS, adverse effect*/ PROSPECTIVE STUDIES/ *SOY BEANS/ VOMITING, etiology PLASTER OF PARIS wvmi imm JJ14. [A neuuoi-cliB*r far relieving lmutioa from pluter et Perl* fntnenU] Allgulender S, et *1. lAkertldnlntee 9.35M. 2 Jul 71 <s*t> CASTS. SURGICAL/ -EQUIPMENT AND SUPPLIES/' FRACTURES, therapy/ HUMAN/ METHODS/ 'PLASTER OP PARIS, *Sver*e fleet* PLASTICS ADVERSE EFFECTS SIM* Long-term effecta of plastics. Food Coamat Toxicol 10:567-71. Aug 71 (41 ref.) ANIMAL EXPERIMENTS/ AORTIC VALVE, nurgery/ BREAST, aurgery/ BREAST NEOPLASMS, chemically Induced/ FEMALE/ HUMAN/ HYPERSENSITIVITY/ INTRAUTERINE DEVICES, adverae effecta/ PLASTICS, adverae effect#/ 'PROSTHESIS, adverae effect!/ RATS/ REVIEW/ SARCOMA, chemically Induced/ SILICONES/ SURGERY, PLASTIC/ TIME FACTORS tass. tpgftggi ixWedmrnmmmmtf&mifn&tMi ln*u*fc*es Him Notts TG. et al. Gig Tr Prof Zabol 16:18-30, Jun 71 (Eng. Abatr.) (Rua) BILIARY TRACT DISEASES, chemically induced/ ENGLISH ABSTRACT/ HUMAN/ LIVER DISEASES, chemically Induced/ OCCUPATIONAL DISEASES, chemically induced/ 'PLASTICS, adverae effecta 3336. (Preoperative aasessment of ruk factors in chip implanu of the oose] llcllmlch S. UNO 20:218-20. Jul 72 (Eng. Abatr.) (Gr> CARTILAGE. transplantation/ ENGLISH ABSTRACT/ HUMAN/ 'NASAL SEPTUM, urgery/ 'PLASTICS, adverae effecta/ RHINOPLASTY/ RIBS, transplantation/ TRANSPLANTATION, adverae effecta/ TRANSPLANTATION, AUTOLOGOUS 3337. Migration of a phihata'e *s;er plasiietz^r from polyvlnylchlorldcbtood bags into Stored human blood and its localisation in human iluuci. Jaeger HJ, ct al. N Engl J bird 287:1114 6, 30 Nov 72 ADIPOSE TISSUE* metabolism/ ANIMAL -TV ^ C- * / EXPERIMENTS/ 'BLOOD PHMS'KllVATJON, limlnmiffitatl.tn/ IlLOOIl TRANSFUSION/ CJILOIllNK/ f.TlHOM ATOGK At`Jf Y, /.AS/ DtSPOSAIU.K KUUIPMKNT/ DOGS/ FKMALK/ HEART SURGERY/ HUMAN/ LIVER, metabolism/ LUNG, metabolism/ MALE/ 'PHTIIALIC ACID/ PHTHAUC ACID, blood/ PUTHALIC ACID, metabolism/ PHTHALIC ACID, urine/ 'PLASTICS/ PLASTICS, adverae effects/ -POLYVINYLS/ POLYVINYLS. meUboliam/ SPLEEN, metabolism/ TIME FACTORS 3336. The Invisible pollution. Hall Dp. N Engl J Med 287:1146-7, 30 Nov 72 BLOOD PRESERVATION, instrumentation/ BLOOD TRANSFUSION/ CHLORINE/ DISPOSABLE EQUIPMENT/ ENVIRONMENTAL POLLUTION/ HUMAN/ PHTHALIC ACID, adverse effects/ PHTHAUC ACID, blood/ PHTIIALIC ACID, metabolism/ 'PLASTICS, adverse effects/ POLYVINYLS, adverse effects/ POLYVINYLS, metabolism TOXICITY - 3339. The carcinogenesis of plasties used In orthopedic surgery. An assessment of tbe incidence to rats snd the possible relevance to man. Lavorgna JJ. et si. CUn Ortbop M;239-7, 1872 ABDOMINAL NEOPLASMS, chemically induced/ ANIMAL EXPERIMENTS/ CARCINOGENS/ EPOXY RESINS, toxicity/ FIBROSARCOMA, Chemically Induced/ GLASS, toxicity/ MALE/ METHYLMETHACRYLATE, toxicity/ NEOPLASMS, EXPERIMENTAL, chemically induced/ 'ORTHOPEDICS/ PLASTICS, toxicity/ POLYETHYLENES, toxicity/ RATS/ TIME FACTORS PLATINUM ADVERSE EFFECTS 3340. Inhalation teats with chemical allergens; complex salts of plstinum. Pickering CA.' Free R dec Med 6S.272-4, Mar 72 ALLERGENS, diagnostic use/ ASTHMA. Chemically induced/ HUMAN/ NOSE/ OCCUPATIONAL DISEASES, diagnosis/ PLATINUM, adverse effects/ 'PLATINUM, diagnostic use/ RESPIRATORY HYPERSENSITIVITY, chemically induced/ RESPIRATORY HYPERSENSITIVITY, diagnosis/ SKIN TESTS/ SPIROMETRY PLUTONIUM ADVEILS! tmm 3341. Metabolism and biological effects of inhaled 241 Am and 339 Pu in dogs. Buldakov LA, et al. Health Fhys 22:673*4. Jun 72 AEROSOLS/ 'AMERICIUM/ AMERICIUM, adverse effects/ AMERICIUM, metabolism/ AMERICIUM, urine/ ANIMAL EXPERIMENTS/ DOGS/ LUNG, pathology/ LUNG, radiation effects/ NITRATES, metabolism/ OXYGEN. Mood/ 'PLUTONIUM/ PLUTONIUM, adverse effects/ PLUTONIUM, metabolism/ PLUTONIUM, urine/ RADIATION EFFECTS/ RESPIRATION, radiation effects/ SCLEROSIS, etiology 2342. Interpretstion of human urinary excretion of plutonium for cases treated with DTPA. Jeeb JJ. et aL Health Pbys 22:787-92. Jun 72 AEHOSOLS/ *DTPA. therapeutic use/ HUMAN/ NITRATES, adverae effect*/ OXIDES, adverse effect*/ PLUTONIUM, adverae effects/ PLUTONIUM, metabolism/ PLUTONIUM, urine/ 'RADIATION INJURIES, drug therapy/ RADIATION INJURIES. . etiology/ RADIATION INJURIES, prevention A control/ RADIATION INJURIES, urine/ TIME FACTORS 3343. Distribution snd toxicity of 230 Pu In bone. Jee WS. flealth Pbyt 22:503*93, Jun 72 ADMINISTRATION, ORAL/ AEROSOLS/ AGE FACTORS/ ANIMAL EXPERIMENTS/ AUTORADIOGRAPHY/ 'BONE AND BONES/ BONE AND BONES, metabolism/ BONE MARROVt. metabolism/ RONE MARROW, pathology' bONE NKUri.ASMS, pathology/ DOGS/ INJECTIONS. INTRAMUSCULAR/ INJECTIONS, tNTKAPfrllUTONEAL/ INJECTIONS, INTRAVENOUS/ INJECTIONS. SUBCUTANEOUS/ NEOPLASMS. A-269 OLI 4977 JS AND CHEwJJCALS fr <Oer> . <W iKNTIAL/ 'i . <>U0l4|y' srif\ jiLASTIC, uilugy/ ISSION/ fM >iherapy in f^reinnma. Aug 7* i:C(A* 1C therapy/ therapy/ -apy/ i%r f ARRHEA, VDISS/ -ulueed/ title nae/ f$TINK ' tie* end Ihelr n (Eat. (Oh) iM/ */ UMAN/ tnpyf -apy/ QSIS, ?y/ \<%Aam <Oe?> "OMA A. 'MS, <bu*, L ^ ji. t py/ ARIfl-T/ *C|]|.f)|(JIKV I.I.mm)/ COGNITION MNOKLKHS, rhrtfilr illv Induced' GIUCON),, thrraprul'c ue/ HUMAN 'llYI'ONATltKMlA, chemically lntluc*l/ IlYpONATllKMlA, therapy/ INFUSIONS, PAiirNTKRAL' INJECTIONS. INTRAVENOUS/ ISOTONIC solutions/ lkukkmia. LY.VHIOMLASTK- dnif therapy/ MAM*:/ POTASSIUM, therapeutic uxe/ SODIUM. M>UIUM ClILOltJDK. therapeutic use*' VINCRISTINE, administration 4 dosage/ 'VINCRISTINE, adverse effect*/ WATKH-ELECTKOLYTE BALANCE 55J8, (1st esperlenccs wilb AtlrUmycln. a new c>ti>tuiic antlbloLlc, In combination chemotherapy oI malignant lumoraj Jungl WE, ct al SchwelaMed Wocbenschr 102:1213-21.20 Aug 72 (Eng Abstr.) (Gr> ADOLESCENCE/ ADULT/ AGED/ ANTIBIOTICS, ANTINEOPLASTIC, administration 4 dosage/ ANTIBIOTICS, ANTINEOPLASTlC. adverse effects/ ANTIBIOTICS, ANTlNEOPLASTtC. therapeutic ute/ BREAST NEOPLASMS, drug therapy/ CARCINOMA, drug therapy/ DRUG SYNERGISM/ ENGLISH ABSTRACT/ FEMALE/ HUMAN/ LEUKEMIA, MYELOBLASTIC, drug therapy/ LUNG, radiography/ MALE/ MIDDLE AGE/ NEOPLASM METASTASIS/ OVARIAN NEOPLASMS, drug therapy/ PREDNISONE, administration 4 dosage/ REMISSION/ SARCOMA, drug therapy/ 'TETRACYCLINE, administration 4 dosage/ VINCRISTINE, administration 4 dosage/ VINCRISTINE, advert* effects IMS, Vincristine-Induced syndrome of inappropriate secretion of antidiuretic hormone. Oldham RK, et at Sooth Mad 2 S'lGW*i. Aug 72 FEMALE/ HUMAN/ * HYPONATREMIA, Chemically Induced/ HYPONATREMIA, diagnosis/ MIDDLE AGE/ SARCOMA. RETICULUM CELL, drug therapy/ TONSILLAR NEOPLASMS, drug therapy/ VASOPRESSIN, seeratloo/ `VINCRISTINE adverse effects &&40. [Vinca alkaloids, a newer group of aotl-oeoplaaUc drugs] Hansen I. et al. Vgeskr Laeger U4:121$*2l, 12 Jun 72 (71 ref.) (Eng. Abstr.) (Dsn) ANIMAL EXPERIMENTS/ CHORIOCARCINOMA, drug therapy/ DOGS/ ENGLISH ABSTRACT/ HODGKIN'S DISEASE, drug therapy/ HUMAN/ IMMUNOSUPPRESSION/ LEUKEMIA, drug therapy/ 'NEOPLASMS, drug therapy/ NEPHROBLASTOMA, drug therapy/ NEUROBLASTOMA, drug therapy/ REVIEW/ VINBLASTINE, administration 4 dosage/ VINBLASTINE, adverse effects/ VINBLASTINE, therapeutic use/ VINCRISTINE, administration 4 dosage/ VINCRISTINE, adverse effects/ VINCRISTINE, therapeutic use POISONING 6*4L Syndrome of inappropriate secretion of antidiuretie hormone produced by vlncristioo toxicity (with bioaaaay of AOH level). Susklnd RM, et al. J Fftdiatr 11:20*2, Jui 72 biological assay/ child, preschool/ EXTRACELLULAR SPACE/ FEMALE/ HUMAN/ HYPONATREMIA, chemically induced/ HYPONATREMIA, drug therapy/ KIDNEY NEOPLASMS, therapy/ MEDICATION ERRORS/ NEPHROBLASTOMA, therapy/ OSMOLAR CONCENTRATION/ SODIUM CHLORIDE, therapeutic use/ SPECIFIC GRAVITY/ URINE, analysis/ VASOPRESSIN, blood/ *VASOPRESSIN, secretion/ VINCRISTINE, poisoning/ WATER.ELECTROLYTE BALANCE, drug effects VINYL COMPOUNDS POISONING IM1 Til- i>t,IMI.i if dlaiool mB nWMMiUl .juuinwuttm *Kkt MaM 1* uwt obloctdo- S(iirw.Nti nww wn tnMHrw ). n Aik po'.mition' I --v.: BU/Oll PKENNUIl/- BLOOli l-liill US'. CHLORIDES' ENVIRONMENTAL lAPONURE' ENVIRONMENTAL HEALTH' HEMOGLOBIN' HUMAN/ INDUSTRIAL MEDICINE' Sf DRUGS/ J/ JAIINUKW, rimmUnlly Induced' MALE/ MODELS, THEORETICAL/ 'OCCUPATIONAL DISEASES, Chemically induced/ RETROSPECTIVE STUDIES/ bULKOimOMOPDTIlAI.EIN, blood/ TIME FACTORS/ VINYL COMPOUNDS, poisoning VIOMYCIN ADVERSE EFFECTS *543, Drug reactions. 18. Cutaneous reactions to antituberculous drugs. Levantine A, et at. Hr J Dermatol 80:631*5, Jun 72 (57 re/,) AMINOSALICYLIC ACID, adverse effect#/ ANTirUIiKJtUULAH AGENTS, adverse effects/ CAPttEOMYCIN, adverse effects/ CYCLOSERINE, adverse effects/ DERMATITIS MEDICAMENTOSA/ XTHAMBUTOL, adverse effects/ ETHIONAMIDE, adverse effects/ HUMAN/ ISONIABID. adverse effects/ 1SON1COTINIC ACID, adverse effects/ KANAMYCIN, adverse effecU/ PYRAZ1NAMIPE. adverse effect#/ REVIEW/ RIFOMYC1N. adverse effect#/ SKIN, drug effects/ STOMATTTIS, chemlesliy Induced/ STREPTOMYCIN, adverse effects/ THIACETAZONE. adverse effecU/ VIOMYCIN, adverse effects SUL Hypocalcemia, hypomagnesemia and hypokalemia during chemotherapy of pulmonary tuberculosis Venule B. et aL Chest 1149*4. May 72 ALKALOSIS, chemically induced/ HUMAN/ HYPOCALCEMIA, chemically induced/ HYPOKALEMIA, chemically induced/ MAGNESIUM, blood/ MALE/ MIDDLE AGE/ PHOSPHORUS, blood/ PYRAZ1NAMIDE. administration 4 doiage/ 'PYRAZINAMIDE, adverse effects/ TETANY, chemically Induced/ TUBERCULOSIS, PULMONARY, drug therapy/ VIOMYCIN. administration 4 SMI. ITuborcvloeUtics. General adverse effects] Mordasini ER, et aL let Z mu Pkarmakol Tber Texikol 9:4W-5lft. Feb 72 (Ger) ADULT/ AMtNOSALlCYUC ACID, adverse effecU/ `ANTITUBERCULAR AGENTS, adverse effect#/ ANTITUBERCULAR AGENTS, toxicity/ CYCLOSERINE, adverse effecU/ DRUG HYPERSENSITIVITY/ DRUG RESISTANCE. MICROBIAL/ ETHAMBUTOL, advert# cffecu/ ETHIONAMIDE. advert* effecU/ FEMALE/ HUMAN/ ISONIAZID, adverse effect#/ KANAMYCIN, adverse effecU/ MALE/ MIDDLE AGE/ NEOMYCIN, adverse effecU/ OXYTETRACYCUNE, adverse effect*/ RlFOMYClN, adverse effecU/ STREPTOMYCIN, adverse effecU/ THI0SEMICARBAZONES,. adverse effeCU/ INI The diary patient. Feparetla MM. Poctgratf Med $2:97-102, Aug 73 diazepam, therapeutic use/ drainage/ EAR, Injuries/ EAR NEOPLASMS, complication*/ ETHACRYNIC AClO, adverse ffleets/ GENTAMICIN, advert* effect*/ HEARING DISORDERS, etiology/ HUMAN/ INFLAMMATION, complication*/ KANAMYCIN. adverse effect*/ LABYRINTH DISEASES, complication*/ LABYRINTH DISEASES, etiology/ MENIERE'S DISEASE, complication*/ MENIERE'S DISEASE, diagnosis/ MENIERE'S DISEASE, drug tberapy/ NEOPLASM METASTASIS/ POSTURE/ STREPTOMYCIN, adverse effects/ STREPTOMYCIN. therapeutic use/ 'VERTIGO/ VERTIGO, chemically Induced/ VERTIGO, diagnosis/ VERTIGO, etiology/ VERTIGO, surgery/ VESTIBULAR FUNCTION TESTS/ VESTIBULAR NERVE/ VIOMYCIN, adverse effect* VIRAL VACCINES ADVERSE EFFECTS Ruboli, v.eetn,Uo& durlAS pr.fri.ncy Bolo.DC, HJ, rt 1 Am 1 O.IU1 Gyntcol m:03t. 1 Apr T2 ABORTION/ ADOLESCENCE' ADULT/ ANTIBODIES/ FEMALE/ FETUS, microbiology/ HEMAGGLUTINATION' INHIBITION Tests/ human/ PLACENTA microbiology/ PREGNANCY' `PIIKlNANCY ' COMPLICATIONS. INFECTIOUS, cliol..*!' RUBELLA, ImmuBoloty/ KURELLA VACCINE advcrM ofloeti/ `RUBELLA VIRUS' OLI 4978 DRUGS AND CHEMICALS POTASSIUM occurrence/ POISONING, occurrence/ POLYMERS, poisoning TOXICITY 4500. Organic polymer biocompalibiUly And toxicology Blschoff F. Clin Chem 18:809-94, Sep 72 <241 ref.) ACHYLIC KKSINS. therapeutic us-**/ ANIMAL EXPERIMENT*/ ARTIFICIAL ORGANS/ ASSISTED CIRCULATION/ DJOCOMPATJULE MATERIALS/ BLOCK) COAGULATION/ CARCINOGENS/ CYANOACRYLATES, therapeutic use/ FREE RADICALS, therapeutic use/ GUINEA PIGS/ HEART, ARTIFICIAL/ HEART VALVE PROSTHESIS/ HUMAN/ INTRAUTERINE DEVICES/ KIDNEY. ARTIFICIAL/ MICE/ PENIS, surgery/ PLASMA SUBSTITUTES, therapeutic use/ POLYMERS, adverse effects/ POLYMERS, therapeutic use/ `POLYMERS, toxicity/ POLYURETHANES, therapeutic use/ `PROSTHESIS/ RABBITS/ RATS/ REVIEW/ SILICONES, therapeutic use/ TISSUE ADHESIVES, therapeutic use 4101. {Comparative characteristics of the biological reaction Of tissues to polypropylene and lethllan-lavaan sutures] Tlurin VG, et al. Von Med Zh 10:76-4, Oct 71 (Bus) ANIMAL EXPERIMENTS/ `POLYMERS, toxicity/ RABBITS/ `SUTURES, adverse effects POLYMYXIN ADVERSE EFFECTS 4501 (Harmful effects of common drugs on the visual apparatus. Antl-lnfectlve drugs. B. Antibiotics] . Dralands L. Bull Soc Beige Ophtalmel 160:390-421, 1972 (Fr> ADOLESCENCE/ ADULT/ AGED/ `ANTIBIOTICS, adverse effects/ BLINDNESS. Chemically Induced/ CEPHALOSPORINS, adverse effects/ CHILD/ CHILD, PRESCHOOL/ CHLORAMPHENICOL, adverse effects/ COLOR BLINDNESS, chemically * Induced/ DIPLOPIA, chemically Induced/ `EYE DISEASES, chemically Induced/ FEMALE/ HUMAN/ MALE/ MIDDLE AGE/ MYOPIA, chemically Induced/ OCULOMOTOR PARALYSIS, chemically induced/ OLIGOSACCHARIDES, adverse effects/ OPTIC NEURITIS, chemically induced/ PAPILLEDEMA, chemically induced/ PENICILLIN, adverse effects/ POLYMYXIN, adverse effects/ RETINAL HEMORRHAGE, chemically induced/ `VISION DISORDERS, chemically induced POLYNUCLEOTIDES TOXICITY 4501 H.moiutic to.Jetty of Poly !*. Gralnlck HR. ot *L Toxicol Appt Phlmuol 25:140-5. Mly 22 ANIMAL EXPERIMENTS/ -BLOOD COAGULATION, dry, effect./ BLOOD COAGULATION tests/ disseminated INTRAVASCULAH COAGULATION, chemically Induced/ DOGS/ FACTOR V. analy.il/ FACTOR VII. analyit./ FACTOR VIII. aaaly.U/ FACTOR IX. analy.U/ FACTOR X. aoaly.1./ FIBRINOGEN. analy.U/ INJECTIONS. INTRAVENOUS/ LEUKOPENIA, chemically induced/ POLY I*C. adminl.tratlon A doufe/ POLY I-C. teatclty/ -POLYNUCLEOTIDES, toxicity/ PROTHROMBIN TIME/ TllltOMnOI'ENIA. Chemically Induced/ TIME FACTORS POLYURETHANES adverse effects 4504. PalAU and painted aurfaco. Piper R. Aon Occup lljt 15:111-4, Apr 72 AEROSOLS, adver.e effect./ CHILD/ CYANATES, pot.nntn./ GREAT BRITAIN/ HUMAN/ LEAD POISONING, ctlnlu.y/ LEGISLATION/ OCCUPATIONAL DISEASES. Prevention A control/ -PAINT, .dvene ertcci.' -POLYURETHANES, advent effect./ SOLVENTS, advene effect. POLYVINYLS adverse effects 4605. Occupational acrooateolysu. Markowiu $5, et al. Arrh Dermatol 106.219-23, Aug 72 ADULTS HONK RESORPTION, blood/ HONK RESORPTION. hloiMl/ `HONK J(KKOltl*TION. chemically induced/ HONK RESORPTION, diagnosis/ BONE RESORPTION, pathology/ BONK RESORPTION. pathology/ BONE RESORPTION, radiography/ HONE RESORPTION. radiography/ HAND DERMATOSES. lilmNl/ `HAND DKHMATOSKS, chemically induced/ HAND DERMATOSES, dlagnoiis/ HAND DERMATOSES, pathology/' HAND DERMATOSES, radiography/ HUMAN/ MALE/ OCCUPATIONAL DERMATITIS, blood/ OCCUPATIONAL DERMATITIS, chemically induced/ OCCUPATIONAL DERMATITIS, diagnosis/ OCCUPATIONAL DERMATITIS, pathology/ OCCUPATIONAL DERMATITIS, radiography/ POLYVINYLS, adverse effects/ POLYVINYLS, adverse effect# POTASSIUM ADVERSE EFFECTS 4506, (Series of studies on heart rhythm disorders. 5. Potassium and rhythm disorders] Zipes DP, et al. Cover Med Interee ll;277>9l, Apr-Jvn 72 (69 ref.) (Eng. Abstr.) (Fre> ANIMAL EXPERIMENTS/ `ARRHYTHMIA, drug therapy/ DOGS/ ELECTROCARDIOGRAPHY/ ENGLISH ABSTRACT/ FROGS/ `HEART CONDUCTION SYSTEM, drug effect*/ HUMAN/ IN VITRO/ POTASSIUM, administration A dosage/ POTASSIUM, adverse effects/ `POTASSIUM, therapeutic use/ RABBITS/ REVIEW 4607. [Reversible hepatic encephalopathy provoked by diuretics] Gaultier M, et al. Eer J Toxicol 4:313*7. Jul-Aug 71 (Eng Abstr.) (Fre> ALKALOSIS, metabolism/ ARGININE, therapeutic use/ CHLOROTHIAZIDE, adverse effects/ `DIURETICS, adverse effects/ DIURETICS, therapeutic use/ ELECTROENCEPIIALOGHAPIIY/ ENGLISH ABSTRACT/ ETHACRYNIC ACID, adverse effects/ FEMALE/ `HEPATIC COMA, chemically induced/ HEPATIC COMA, drug therapy/ HEPATIC COMA, prevention it control/ HUMAN/ HYPOKALEMIA, metabolism/ LIVER CIRRHOSIS, drug therapy/ LIVER CIRRHOSIS, metabolism/ POTASSIUM, adverse effects/ POTASSIUM, metabolism/ POTASSIUM, therapeutic use/ POTASSIUM CHLORIDE, therapeutic uae POISONING 460t. [Suicide attempt with potassium cyanide. ($uieidologic*paychopathologic presentation)) Kapamadllja B Nevroptlhljatrlja 18:347-52, 1970 (Eng Abstr.) (Cro) ADULT/ AFFECTIVE DISTURBANCES, Complications/ `CYANIDES, poisoning/ ENGLISH ABSTRACT/ HUMAN/ MALE/ POTASSIUM, poisoning/ PSYCHOPATHOLOGY/ RESUSCITATION/ `SUICIDE TOXICITY 4506, (Development of renal excretion of sodium and potassium in the postnatal period of the rat) Brtunllch H, el al. Acta Biol Med Ger 28:89*98.1972 (Eng. Abstr.) (Carl AGE FACTORS/ ANIMAL EXPERIMENTS/ ANIMALS, NEWBORN/ ENGLISH ABSTRACT/ FEMALE/ ION EXCHANGE/ `NATRIURESIS/ POTASSIUM, toxlellv/ `POTASSIUM, urine/ RATS/ RATS. INURED STRAINS/ SODIUM CHLORIDE, pharmacodynamics POTASSIUM CHLORIDE ADVERSE EFFECTS 4510. Drug-Induced malabsorption of vitamin B 12 . IV. 'Malabsorption and deficiency of B 12 during treatment with xlow-release potassium chloride. Palva IP. et al Aria Med Stand ltfl.3^5-7, Apr 72 HEART DISKASKS. drug therapy/ HUMAN/ HYDROGEN-ION CONCENTRATION/ ILEUM/ INTESTINAL ABSORPTION, drug effects' `MALABSORPTION SYNDROMES, chemically induced/ MALE `POTASSIUM CHLORIDE, soverse *rt#ets' SCHILLING TEST/ TELEMETRY/ VITAMIN H 12, blood/ `VITAMIN b 12 DEFICIENCY, chemically induced 4511. (Neurologic accidents after subarachnoid injection of A-361 OLI 4979 roUMKUS DRUGS AND CHEMICALS 33 HYDROKKN-ION CONCKNTHATION/ IODINE, list/ METHODS/ MICK/ H0LECU1.AU WKIOIIT' "I'OLYMKHS, diagnostic u*e/ POLYMERS, toxicity/ RABBITS/ SOLUBILITY/ WATER 3395. Polymer* containing phencthylamlne*. Weiner BZ. *t *). J Med Chem 15:410 3, Apr 72 ANIMAL EXPERIMENTS/ BEHAVIOR, ANIMAL, drug effects/ BLOOD PRESSURE, drug effect*/ CATS/ DEPRESSION. CHEMICAL/ FEMALE/ HYDROLYSIS/ infrared RAYS/ LETHAL DOSE SO/ MALE/ MICE/ MICK. INBRED STRAINS/ NUCLEAR MAGNETIC RESONANCE/ PHENETHYLAMINES, chem synthesis/ FHENETIIYLAMINES. phsrmseodynamles/ PHENETHYLAMINES, toxicity/ 'POLYMERS, chem synthesis/ POLYMERS, pharmacodynamics/ POLYMERS, toxicity/ RESPIRATION, drug effceti/ SPECTRUM ANALYSIS/ STRUCTURE ACTIVITY RELATIONSHIP POLYMYXIN ADVERSE EFFECTS 3387. {Problem* of antibiotic administration In nfyattbeaia gravis] Onlshl A. el *1. Adr Neurol Set (Tokyo) 15:904-10, 1871 (Jap) ADULT/ ANTIBIOTICS. administration A dosage/ 'ANTIBIOTICS, adverse effect*/ BACTERIAL INFECTIONS, drug therapy/ CHOLINESTERASE INHIBITORS, therapeutic use/ FEMALE/ HUMAN/ 'MYASTHENIA CHAVIS/ NEUROMUSCULAR DEPOLARIZING AGENTS/ 'NEUROMUSCULAR JUNCTION, drug effect*/ POLYMYXIN, Adverse effect*/ PSEUDOMONAS AERUGINOSA/ PSEUDOMONAS INFECTIONS. dni| therapy/ TETRACYCLINE. adverse effect* POLYNUCLEOTIDES TOXICITY MM, UUrastructural change* in chick cerebellum induced by polyinestnic polycytldylic *cid. Yu MC, et *L Am J Pathol 64:305 20. Aug 71 ANIMAL EXPERIMENTS/ CELL NUCLEUS/ 'CEREBELLAR DISEASES, Chemically Induced/ CEREBELLAR DISEASES, pathology/ CEREBELLUM, drug effect*/ CEREBELLUM, pathology/ CEREBRAL ARTERIES, pathology/ CHICKENS/ DENDRITES/ ENDOPLASMIC RETICULUM/ MICROSCOPY, ELECTRON/ MICROTUBULES/ MITOCHONDRIA/ NERVE FIBERS. MYELINATED/ POLY LC, pharmacodynamic*/ POLY J*C. toxicity/ -POLYNUCLEOTIDES, toxicity/ PURKINJE CELLS/ RIBOSOMES/ TIME FACTORS POLYSACCHARIDES adverse effects 3388. {FerrlC'polyRUltoaldt. New therapeutic eld in \ hypochromic anemia of childhood} Sendim de Si DS, et *1, Rev Brea Med 28:81*4. Feb 72 (For) ANEMIA, HYPOCHROMIC, drug therapy/ CHILD/ CHILD, PRESCHOOL/ EVALUATION STUDIES/ FEMALE/ HUMAN/ INFANT/ INJECTIONS, INTRAMUSCULAR/ IRON, administration 4 dotage/ IRON, advert* effect*/ -IRON, therapeutic u**/ MALE/ MALTOSE, administration 4 dotage/ MALTOSE, adverse effect*/ MALTOSE, therapeutic use/ POLYSACCHARIDES, administration 4 doeag#/ POLYSACCHARIDES, adverse effect*/ -POLYSACCHARIDES, therapeutic use POLYSACCH AUI OKS, BACTKIUA1. TOXICITY 3800. {Some properties of polysaccharide complexes obtained from cholerallke vibrios] Vvcdenittaia Ol, et at. Zb Mlkroblol Epidemiol ImmBuoblo! 48.38*43, Mar 72 (Eng. Abm.) (Rot) ANIMAL EXPERIMENTS/ BACTERIAL ANTIGENS/ F.NM.lMl ATTRACT* IMMUNOELECTROPHORESIS, LETHAL DOSE 50/ VICE/ 'POLYSACCHARIDES, BACTERIAL/ POLYSACCHARIDES. BACTEKIAL, toxicity/ 'VIBRIO A-296 .^5 - { 'K. (-r I POLYUKETIIANKS TOXlCtTY 3801, Comparison between in vitro toxicity of dust* of certain polymer* and mineral* and their flbrogenlclty. Conning DM, ct al. Inhaled Fart Vap 3:499.504, 1870 ANIMAL EXPERIMENTS/ ASBESTOS, toxicity/ AUTOANALYSIS/ CALCIUM CARBONATE, toxicity/ CELLS, CULTURED, drug effect*/ -DUST/ FEMALE/ IN VITRO/ MACROPHAGES, drug effects/ MALE/ 'MINERALS, toxicity/ PIITHALlC ACID, toxicity/ POLYETHYLENE5, toxicity/ POLYMERS, toxicity/ POLYURETHANES, toxicity/ RATS/ RATS, INBRED STRAINS/ STRUCTURE ACTIVITY RELATIONSHIP/ TIME FACTORS POLYVINYLS POISONING 3803. Case history: ieroe*teoly*li. Occep Health (Lend) 24:173, May 72 BONE RESORPTION, chemically Induced/ FINGERS/ OCCUPATIONAL DISEASES, chemically induced/ POLYVINYLS, poisoning/ SPECIAL UST NURSING POTASSIUM ADVERSE EFFECTS 3803. A gaatrolnteatlnai problem. Wilkinson B, et *i Br Med J 1:787*8, 25 Mar 72 ABDOMEN/ HUMAN/ HYDROCHLOROTHIAZIDE, adverse effects/ HYPERTENSION, drug therapy/ ILEUM, Surgery/ 'INTESTINAL DISEASES, chemically Induced/ INTESTINAL OBSTRUCTION, Chemically induced/ MALE/ MIDDLE AGE/ PAIN/ -POTASSIUM, adverse effect*/ RESERPINE, adverse effects/ ULCER, chemically induced 330%, {Evaluation of obscure repolarlaatlon disturbances in theelectroeardlogramm with oral potassium] Stutg R, et al. ftehwtii Med wochenaehr 102:403*5, 25 Mar 73 (Eng. Ahstr.) (Gen ADULT/ -ELECTROCARDIOGRAPHY/ ENGLISH ABSTRACT/ FEMALE/ HEART, phytopathology/ 'HEART DISEASES, diagnosis/ HUMAN/ MALE/ MIDDLE AGE/ POTASSIUM, administration 4 dosage/ POTASSIUM, adverse effect*/ -POTASSIUM, diagnostic use POISONING 3305. (Occupational contact ecxema due to potassium .gold cyanide] Schmollack . , Dermatol Monadichr 157:331-4, Nov 71 (Eng. Ahstr.) ' (Gcr) CONJUNCTIVITIS, chemically induced/ CYANIDES, poisoning/ -DERMATITIS, CONTACT, etiology/ ECZEMA, chemically Induced/ ENGLISH ABSTRACT/ FACIAL DERMATOSES, ehemicaUy induced/ FEMALE/ -GOLD, polaoning / HAND DERMATOSES, ebemlealiy induced/ HUMAN/ HYPERSENSITIVITY/ OCCUPATIONAL DERMATITIS, chemically Induced/ POTASSIUM, poisoning/ SKIN TESTS/ TIME FACTORS TOXICITY 380d. Effect* of nicotine and sympathomimetic amines on potassium intoxication. Lum BK, et al. J Pharmacol Ftp Tfccr lft\'t47>S4. Apr 72 ADRENERGIC ALPHA IlKt'F.ITOll AGONISTS, ph^rnuriHjynamlr*/ ADRENERGIC BETA RECEPTOR AGONISTS, pharmacodynamics/ ANIMAL EXPERIMENTS/ ATROPINE, pharmacodynamic*' BLOOD PRESSURE, drug effects/ 'CATECHOLAMINES, pharmacodynamic*/ CATS/ CHLOR1SONDAMINE. pharmacodynamics/ DOGS/ ELECTROCARDIOGRAPHY/ EPINEPHRINE, pharmacodynamics/ FEMALE/ HEART RATE, drug effect*/ I5OPROTFHEN0L. pharmacodynamic*/ MALE' NEPHRECTOMY. 'NICOTINE, pharmacodynamic*/ PllKNOXYBKNZA MINE, pharmacodynamic*/ PHENYLEPHRINE, pharmacodynamic*/ POTASSIUM, antagonists 4 inhibitor*/ POTASSIUM, blood/ 'POTASSIUM, toxicity/ PROPRANOLOL, pharmacodynamics/ OLI 4980 I'Ol.YSTYItr.NKS DRUGS AMD CHEMICALS POI.YSTYKHNES TOXICITY 3001. IDiU on hyglontc lest* of some polymer materials used In house construction] RUnWevlch Jti, et *1. Vrtcli Drlo S'lOS-9, May 68 (Hus) ANIMAL EXPERIMENTS/ ENGLISH ABSTRACT/ ENVIRONMENTAL EXPOSURE' 'HOUSING/ HUMAN/ MAXIMUM PERMISSIBLE EXPOSURE LEVEL/ POLYMERS, toxicity/ POLYSTYRENES, toxicity POLYTHIAZIDE ADVERSE EFFECTS 3002. (Hyperparathyroidism caused by thiazides] Deulsrh Med \V*ehr 95:344, 30 Jan 70 (Ger) ANTJIIYFKUTLNSIVK AGENTS, adverse effect*/ CHLOROTHIAZIDE., adverse etteet*/ HUMAN/, HYDROCHLOROTHIAZIDE, adverse effects/ `HYPERPARATHYROIDISM, Chemically Induced/ HYPERTENSION, complications/ HYPERTENSION, drug therapy/ POLYTHIAZIDE, adverse effects/ TIME FACTORS POLYURETHANES TOXICITY 3903* Hemolysis associated with plastlet-a histopathologic study with polyurethane. Higdon RII. J Itiemcd Mat Res 4:57-71, Mar 70 ANIMAL EXPERIMENTS/ CARBON/ CREATINE, metabolism/ `ERYTHROCYTES, drug effecu/ FLUOROCARBON POLYMERS/ CLASS/ GRANULOMA, chemically Induced/ HEMOLYSIS/ HEMOSIDERIN, metabolism/ MICE/ NYLON/ `POLYURETHANES, toxicity/ RATS/ RESINS POLYVINYLPYRROLIDONE ADVERSE EFFECTS 3004, [Polyvinyl disease] Cahsnne F, et aL An Anat Path (Paris) 14:419-39, Oct-Dec 69 (Fre) ADULT/ ANIMAL EXPERIMENTS/ BONE DISEASES, chemically Induced/ CAPILLARIES, pathology/ ENGLISH ABSTRACT/ FEMALE/ GUINEA PIGS/ HEPATOMEGALY, chemically induced/. HISTIOCYTES, enzymotogy/ HUMAN/ INFLAMMATION, chemically Induced/ JOINT DISEASES, chemically induced/ LUNG DISEASES, chemically Induced/ LYMPH NODES, pathology/ MALE/ MIDDLE AGE/ MUSCULAR DISEASES, chemically Induced/ POLYVINYLPYRROLIDONE, adverse effects/ POLYVINYLPYRROLIDONE, snslysls/ SKIN DISEASES, chemically Induced/ SPLENOMEGALY, chemically induced POLYVINYLS v ADVERSE EFFECTS 1003. Prolonged endotracheal intubation or tracheostomy In infant* and chUdran. Manila MA. et aL J Petflal Surf 4:674-12, Dec 68 CHILD/ CHIU), PRESCHOOL/ COMPARATIVE STUDY/ FINLAND/ HUMAN/ INFANT/ INFANT, NEWBORN/ `INTUBATION, INTRATRACHEAL/ INTUBATION. INTRATRACHEAL, adverse offeeta/ INTUBATION, INTRATRACHEAL, Instrumentation/ LARYNX, Injuries/ POLYVINYLS, adverse effects/ RUBBER, advene effect*/ TIME FACTORS/ TRACHEAL STENOSIS, etiology/ `TRACHEOTOMY 3004. [Development of araehnoendothcllal accumulations tn the dura mater following alloplasty of Its defeeta under experimental condition*) Maforova NA, et al. Vop Nelrokhir 33:50*3, Jul-Aug 69 <Rus) ANIMAL EXPERIMENTS/ `ARACHNOID, pathology/ DOGS/ DURA MATER, pathology/ DURA MATER, surgery/ FEMALE/ MALE/ POLYVINYLS, adverse cHects/ *SURGERY, OPERATIVE, adverse effects 3007. [Effect r.( petrolcur.i hydrocarbons on tbe condition of the cardioviscuUr s>stem In UUeaact of the gastrointestinal tract] B**hlrov AA. Vracb Delo 11.559, Nov 67 (Rus) ADULT/ `CARDIOVASCULAR DISEASES, etiology/ ENGLISH ABSTRACT/ ENVIRONMENTAL EXPOSURE/ FEMALE/ A-214 GASTROINTESTINAL DISEASES, etiology/ HUMAN/ MALE/ OCCUPATIONAL DISEASES, chemically Induced/ POLYVINYLS, adverso effecu/ `STYRENES, adverse effect* POISONING 3003, [`Polyneuritis craniali** following poisoning with chlorinated acetylenes In connection with vtnylldene copolymers] Jlcnachlcr D, et al. Arch Toxin 20:62-75, 197C (Gar) ACETYLENE, poisoning/ ADULT/ ALKYNES, poisoning/ `CRANIAL NERVES, pathology/ ENGLISH ABSTRACT/ ENVIRONMENTAL EXPOSURE/ HUMAN/ HYDROCARBONS, HALOGENATED, poisoning/ HYPOGLOSSAL NERVE, drug effects/ MALE/ MASTICATORY MUSCLES, drug effects/ MIDDLE AGE/ OCULOMOTOR MUSCLES, drug effecu/ 'POLYNEURITIS, chemically induced/ `POLYVINYLS, poisoning/ TRIGEMINAL NERVE, drug effecu/ TRIGEMINAL NERVE, pathology PORPHYRINS ADVERSE EFFECTS 3099. [Significance of lyaoaemea for cutaneous photoaensitliallon by porphyrins and other sensitizers] Magnus 1A. Arch Klin Ksp Derm <37:494*4, 1970 (Ger) ACID PHOSPHATASE, analysis/ ANIMAL EXPERIMENTS/ BENZENE HEXACIILOJUDE/ HUMAN/ `LYSOSOMES, ensymology/ LYSOSOMES. radiation effects/ PHOTOSENSITIZATION, chemically Induced/ PHOTOSKNSITIZATION, ensymology/ PHOTOSENSITIZATION, etiology/ P0RPHYMA, Complication*/ -PORPHYRINS, adverse effect*/ RADIATION EFFECTS/ SELF MEDICATION/ THIOCARBAMATES POTASSIUM ADVERSE EFFECTS 3910. (Pain producing substances] Keele CA. KUppoKrates 40:777-82, 31 Oct 69 (Ger) CUKMORKCEPTORS, drug effects/ EXTRACELLULAR SPACE/ HISTAMINE, adverse effect*/ HUMAN/ KINI NS. adverso effect*/ `PAIN, chemically induced/ PAIN, ettology/ POTASSIUM, advert# effects/ SEROTONIN, adverse effects MIL Increase In thyrotoxicosis in endemic goitre area after locution of bread. Connolly RJ, at aL Lancet 1:3094, T Mar 70 ADOLESCENCE/ ADULT/ ACE FACTORS/ AGED/ AUSTRALIA/ `BltEAD/ CHILD/ GOITER, complications/ `GOITER, prevention A control/ GOITER, ENDEMIC, prevention A control/ HUMAN/ HYDROXIDES, administration A dosage/ `HYDROXIDES, adverse effects/ `HYPERTHYROIDISM, chemically induced/ HYPERTHYROIDISM, occurrence/ IODIDES, administration A dosage/ `IODIDES, adverse effects/ MIDDLE AGE/ POTASSIUM, adverse effect* SOil. [Chemical mediators of pain] Musto P, et *L Minerva Attest 33:1163-71. Nov 69 (1U> ACETYLCHOLINE, adverse effects/ `AMIDES, adverso effects/ `CATECHOLAMINES, adverse effecU/ ENGLISH ABSTRACT/ HISTAMINE, adverse effects/ HUMAN/ `KININS, adverse cffecU/ `PAIN, chemically Induced/ I'AIN, etiology/ `POTASSIUM, adverse offccU/ SEROTONIN, adverse effect* POISONING 3013. Acute potassium dlchromale poisoning. Treated by peritoneal dialysis. Kaufiian DO, t al. Amr J Dll Child 119 374 6. Apr 70 ACUTE DISEASE/ ADOLESCENCE/ ASCORBIC ACID, therapeutic use/ AUTOPSY/ BRAIN CHEMISTRY/ CHROMATES, poisoning/ CHROMIUM, blood/ tMMttlCAPROL. thcfipcutlc use/ HUMAN/ KIDNEY, pathology' LIVER, pathology/ MALE/ `PERITONEAL DIALYSIS/ POISONING, drug therspy/ `POISONING, therapy/ `POTASSIUM, poisoning 30)4. [Transfusion reactions] Bube FW. Internist (Berlin) 19.46-51, Feb 49 (Ocr) OLI 4981 ///. 7901 394 96R VUL=79 ISS = ^4 SLC. = `j9 wr=ll CA447CAKD 30 ' HYG1LNIC I'VALWMION OF WORKING CONDITIONS IN SUML CMLMICAL I. 10.ANTS OPERATING IN THE OPEN AIR FILATOVA, V. S. / VINOGRADOVA, V. K. BASHKIROVA, L, S, , C INST, GIG. TR. PROFZABOl. / GORKI / USSR i GIG. TR. PROF. ZABOL. i GTPZAB, VOL i C //KEYWORDS// ,ISS 8 , YR 1973, PGS 8 -11 ; AMMONIA PRQDN HYGIENE f V1NYL CHUDK1 DE J>RD6nW6T Ebl E ACS COPYRIGHT 1973,CA-CONDENSATES ~) ') ^ ) c. o //? 79002315J VOL= 79 ISS= 04 WT= 11 CA447CAR0 59 l7 ` HYGIENIC CERTIFICATION OF THE BUILDING PROJECTS, DfcVELGPMEN T, AND RECONSTRUCT ION OF PLANTS PRODUCING ORGANUCHLURINE PR ODUCTS (. ' LEVINA, M. M. / FILATOVA, V. S. / BELAYA, E. G. ASHIROVA, S. A. / TIKHOMIROV, YU. P. / LEVIN, A. L. MOSTINSKAYA, R. Z. / KUZNETSKII, P-. E. i INST. GIG. TR. PR0F7AB0L. / GORKI / USSR GIG. SAN1T. GISAAA, VOL . l.SS 4 ,YK.73,PGS 86- 7 , SEC 59 //KEYWORDS// ORGANOCHLOr, iNfc MANlJF HYGIENIC CERTIFICATION PVC MANIJT HYGIENIC CERTIFICATION. ( . VINYL CMLIJkIdC MAHNO HYGIENIC CERTIFICATION POLYCHLOKOPkcNE MANOR HYGIENIC CERTIFICATION TRICHLOROETHYLENE MANUF HYGIENIC CERTIFICATION I ACS COPYRIGHT 1973,CA-CONDENSATES l/t 790 1 44974Z V0L = 79 ISS = 25 SEC = 17 WT= 9 CA347CARD 13 SANITARY-HYGIENIC PROPERTIES OF COMPOSITIONS MADE OF POLYlV ^ INYL CHLORIOE) STULOVA, L. I. / SHARGORODSKII, A. M. USSR ^ TR. KHIM. KH1M. TEKHNOL. ~ TKKTAE, VOL //KEYWORDS// ,ISS 3 , YR 1972, PGS 139- 42 ** FOOD PACKAGING POLYVINYL CHLORIOE ACS COPYRIGHT 1973,CA-CONCENSATES .) ') OLI 4982 ) U- I.U I 1 ,,, II. .11.111 .11-1 il.ill L11->! 1.1 III I, .1 ! < V I I e il il I 1 . ,1 Miph did III*! I r veal MOV I III*tig' -. of I OMxrqurncc | 11 It i |m 1, I 1 I it I I I I' .*1 , I I' ri . I 11 11' I /.III i -' I 0/7 1 1 ' , I 1 i. I. . , 11 I t I I, \ 1 n II 1.1 III |||*I "I Ml '-111 11 1*1: . lirtia Kloi ,1 Ml'l-toe I-'mi'Iiuii idtri ting tlir i ooiitiieilhill of lllli afllli,. i II 5, Mini 5 S . I ml I , I ll'* .1 III t` * I 11 |. 1 Inn. i II III ill III I I ill II II1 ` I III I fioui heoiiiiliiilvi.ix Haiti Ni.lpli, Kml It,; Slolt/, Mnhael t in. 11 ill n In.i ll r. \.i i llu Inn i. In 11 III'i ilp. i I.in nl i lil..i. n iilinf t'.ulii, th.uh". It.; ko\, Mait.iiine; Malo-t, John ft*. (Mci ill. Iinnii hi. . i I. i ;nl. .mil - In ill.1-ill" in .nun I In..1 in'i'iii 4 in I.. Hniv. Missouri, k'oluiobiu, Mo.), irans. Amer. Km :!. 11 ii i >t l.\ i.n mliiiim-liUi.ilnui. 1 in i' uln .wiii-n .IpufiT- Arhf. Intern. Organs, 1970, 15, 495-501 (Eng). Solute tranx ruti.dly iuoi'ii'.iih; In |>l I, mili-cplit' or uumIi* nf Mcrih/;itmn m lhr fnrmtikili'm nf rvi- iislu-s in m i mikim \> il Ii I hr ti ipiti/mint'. >f the Belgian I'h.inii.iinpi'iii mini1,. ZnStJ, NmI-KI, tr.'yrnl, port dmim; the ultrafiltration from a perfused hemodialysis toil may lie affected directly by the membrane, by a Gibbs-Donnnii like phenomenon Iclated to prutem charge, or by an addnl. pro atiupiuc MiUnti1, tirni'Uiin.-HCI, ii'M'iYinnl, pilm-.njiiiii'-IIC'l, tein allinity. New discrepancies in solute and water removal chloramphenicol, l1, m .V , N.i sulfacetamide, 11/ON`a, nr Xu3- during actual hemodialysis may be blunted by augmented dif ll40i as. active constituent. C. K. Addinall fusion. Perfusate protein concn., perfusate. pH and ultrafiltra- 131443p Effect of technological parameters on the quality of tion rate may affect solute removal and must be considered in tablets prepared from granulates produced with industrial fluid* comparative dialyzer performance studies. Variations in factors bed granulation equipment. Hunk, A.; Bczzegh, 1)., likeic* affecting solute transport by ultrafiltration will be particularly ]\ (liiiitci! Works J'liarm, Dirt. 1'rml., Budapest, Jinny.)- iutpoitaut to those designing dialyzers utilizing primarily ultra 1'rcu:. Con}. J'hys. Chan., 2nd 1071, 2, 087-92 (Eng). filtration. P. J. Parisek Edited by Buzas, Ilona. Akad. Kiado: Budapest, Hung. The 131450p Liquid-liquid contactor for extracorporeal blood optimal tech, parameters for granulation on lab. scale and pilot oxygenation. Anderson, Richard Mark; Harris, Grady William; plant were investigated for the fluidized bed spray granulator DePilippi, Richard P.; Weber. David Charles; Malchesfcy, '[ process (rill'). An increase in amt. of binding agent increases Paul S.; Nose, Yukihiko (Abcor, Inc., Cambridge, Mass.). i* *5 -4 roceh. strength and decreases wear loss. An increase in flow rate of fluidizing air and decrease m feeding rate of granulation Jiq., resulted in a particle size decrease, l'hys, parameters of tablets obtained by EBP and wet granulation process (WGP) were in good agreement except that crushing strength for EBP Traits,, /Inter. Sac. Artif, Intern. Organs 1970, 1C, 375-80 (Eng). The concept of continuously contacting blood with a flowing fluorocarbon film for extracorporeal blood oxygenation and COi removal was demonstrated. A 13-channel parallel-plate device has been tested in vitro and in vivo. It bad no effect on hematol. tablet was greater than WGT tablet. L. X. Dhoot variables during runs on calves for durations of up to 5 hr on % r t r rI J31444q Thermal processes during tabletmg. Bogs, U.; Lenhardt, E. (Ger.). Charm, hid. 1971, 33(lla), 850-4 (Gcr). Direct temp, measurement on the surface of tablets during tabletlug, with thermocouples welded into the surface of an epoxy resin bottom punch is described. Oscillog. nas used to det. the temp, rise. Pressure was measured indirectly. An aminophenazoue (I)-$tarch (50;4G) granulation with 6.3yc gelatin soln. with and without added lubricants (2C/ talc or Mg stearate) was used as the test mixt. for O.S g tablets. Temp, increase was propor/tional to the pressure used over wide limits. Addn. of lubricant changed the start of the temp, rise at higher pressures. During compression, the teinp. rise was followed immediately by cooling to the original temp, when the pressure was released. A eutectic powd. mixt. of 40.45:15 J-tlihydropyridine-nicotinatnide of low eutectic point (38) alone gave less cooling of the tablet, fablct- ing mold surfaces and a progressive temp, rise on further com pression cycles due to the formation of a thermally insulating tnolten film. During compression, the effect of heat generation on tablet formation and tablcting difficulties is discussed. X. M. Khanna pumpless partial bypass. The oxygenation capacity was shown to be about 000 cc of blood/min, an Ot transfer rale of about 40 cc of Oi/min-M.* The fluorocarbon, PC-43, appears to be chem. inert both in vitro and in vivo. However, a fluorocarbon trap is required on the blood return line to prevent accidental carry-over of FC-43 because it blocked blood flow in capillaries. P. J. Parisek I31451q Extracorporeal chemical reactor. Martel, L.; Rottcveel, J.; Snider, M. T.; Galletti, P. M. (Div. Biol. Med. Sci., Brown Univ., Providence, R.I.). Trans,, Amer. Sac. Artif. Intern. Organs 1970, 16, 504-7 (Eng). Biochem. specific ity can be achieved in the case of some low mol. wt. plasma solutes by introducing a high mol. wt. enzyme in a closed dialyzate compartment. The hemodialyzer then acts as an extra corporeal reactor in which biochcm. reactions can be imposed without actually introducing the reagents into the blood stream. This system, dubbed "cascade dialysis" permits lowering blood plasma asparagine levels in dogs to negligible values within 4 hr and maintaining low levels by continuous operation of the biochem. reactor. The cascade dialysis system may be of value when the selected enzyme is either rare, toxic or contaminated, 131445r Therapeutic value of bandaging materials as a func or when the development of antiltodies must be preyented. tion of their physicochemical parameters. Novak, Janos; P. J. Parisek Molnar. 1stvan; Szcgo, Iiva; Huszka, Zultan (Magy. Xepti.nl- 131452r Surface chemical evaluation of thromboresistant sereg Kozp, Korhaza, Budapest, flung.). Gyagyszercsztt 1971, materials before and after venous implantation. Baier, R. E.; 15(11), 411-15 (Ilung). The back skin of narcotized rats was removed from 8X0 cm areas and the adhesion.strength of ban dage strips onto the wound surface was detd, with a self con structed app. Also absorptivity of cotton gauze, cotton tulle alone and impregnated with paraffin, polyurethane sponge and polypropylene gauze was examd. with a stain soln. 1'olypropyl ene gauze gave the best performance. Bela Lang Gott, V. L.; Feruse, A. (Cornell Aeronaut. Lab., Buffalo, X.Y.). Trans., Amer. Soc. Artif. Intern. Organs 1970, 16, 50-7 (Eng). Over 20 different thromboresistant materials were studied in the inferior vena cava in small dogs. Three different mechanism became apparent by which various materials become thromborcsistant (o) intrinsic low surface resistance, which became mani fest in erosion resistance, (b) intrinsically high energy surfaces 131446s Adhesion of caries preventive sealing material to the that rapidly form a thin protein film from the blood, (c) materials tooth enamel. Ohsatva, Takeo (Tokyo Dent. Coll., Tokyo, with dcsorltablc surface active agents (heparin, albumin and Japan). Koku Eisei Gakkat Zasshi 1971, 21 il), 53-filf (Japan). surfactants). In all 3 cases a proteinaceous layer must be An improvement of adhesiveness nf lit 2-cyanoacrylatc and poly- formed from the blood and it is this layer which ultimately will (Me methacrylate) caries preventive scaling material to the det. the thromborcsistance of the material. The thickness and enamel surface was proposed by treatment of enamel surface nature of this protein film are important. The materials were with various decalciling soln., such as HC1, phosphoric acid, examd. before and after implantation in the light of these above formic acid, acetic acid, citric acid, pyruvic acid and EDTA. parameters by ir reflectance and by contact angle expts. Polish Of these, the treatment of enamel surface with 3,1/ pyruvic acid contaminated Stellite 21, tridodecylmethylammonium chloride- for 30 sec was the most effective in increasing the adhesiveness heparinized silicone, epoxy surfactants, polystyrene treated with to the sealing material. M. Shimizu albumin, polyurethane-based electrct, diamond polished carbon 131447t The addition of glass filler to caries preventive seat and glow discharge-treated Stellite 21 were examd. Horst Eehl ing material. Oishi, Takahiro (Tokyo Dent. Coll.. Tokyo, 131453s Inconsequentially of surface properties for initial Japan). Koku Eisri Cakkai Znsshi 1971. 21(11, 32- 52 (Japan). platelet adhesion. ITiciimnn. L. I.; I.iitn, II.; Grubowski, The efTeets of aililii. of cl.iv> filler mi the plivs. properties of Hi 2- K. F.: Iaim.trd. H. F.; Mi-Curd. C. W. (Hep. Chem. Eng., rynnn.ieryl.itc and polvi.Me iiieth.iervl.ite) cartes pieventne Columbia Univ.. New York, X.Y.). Trans., Amer. Sac. scaling material were ?>tui!iril. The abra-iori resistance and hard Artif. Intern. Oigans 1970. Hi, 53-73 fEng). Fifteen different ness increased by 70' ) upon addn. of class filler, and water types of material were examd. with rr-pect to platelet adhesive absorption decreased. The addn. of glass filler treated with ness by (a) platelet adhesion examd. ax a function of exposure 0.05-1.0/c Silane A-187 or Silane A-174 was more cfTcclBe. time to various flow rates and as a function of const, flow- rate M. Shimizu but various exposure times. (M using the same material but plate / ]31448u Preliminary evaluation of suitability of Polish poly- let adhesion was measured after exposure of the materials to (vinyl chlorides i for medical purposes h'-v.w- hi, kn'il: St.. ,.-, hcparirizi d blood, and if) identical conditions as a but only zewka, Jo..inti \h:nl. Mi;;., V.r^A.ue, pni >. Med, nonheparinized Wood was used. A math, model for platelet 1971. lfl 2', 45-8 11'oT. San,pies ,.( p.ili-h i'VC types 7,1 ti7 diffusion and adhesion was constructed. Either diffusion alone and MV, 58 were implanted under the skin and into peritoneal regulated the process, or possibly both diffusion and reaction tissue of rats for l-'*0 days. The results were compared with are important. The materials studied were; glass, siliconized those obtained with Italian I'VC Sicron CK-S 3, After 5X1 days glass, albumin coated glass, albumin coated siliconized glass, the loss in wt, of the 3 kinds of I'VC was 0.0085, 0.U0GG, and perflunrinated oetanol polymcthaerylatc. poly(vinylpyrrolidonc), 0.0294 mg, Hislol. exanm. of internal organs tissues in contact cellophane, cellulose acetate, fluorinated ethylene propylene ? up 77* OLI 4983  { / 111 (I lit' ,,rlum Ilium inl'e |6,tll-IIS.||| poisoning was inihnid 111 lal, laintiuncil III 111! airtight plexiglass box ......... Nil llnit', mill In .Ill'll ilu* {) whs supplied Irmii *1 I'vhiiiliT iinii its unit, was antrollcd Cnli ii. nf CO liilrnihu i`il wns cnircilcd lur till* vul. nl nnial bodies. Cl) poisoning |5 mi: CO/1.) resulted in .m tcrease of the ERYTHKUPOIE'I IN LEVEL in blood pin-inn Iter2 hr. D F. Kalab 'J5339y Determination of lead in plant films with a portable .otope fluorescence analyzer. Marltrt>. 0.; Harford, C. 1..; ..i.ilu. N. .1. 1'. Il'i'ili.itr. Cult, St. Mnrv's Hosp Med. Srli., 'lulou. Engl.l Hull, Fm iron Coidnai Tu.uml. 197). (idi). u2 8 (Eng) The application m \ rhy lluoresconcc to the detn. a lead (7439-92 11 content of PAINT FILMS was evaluated mug a portable isotope fluorescence analyzer. Accurate detus. icre achieved in the laboratory using prepd. films in which the 'll was dispersed through matrices of constant entupn. in a ogle layer. The presence ol Pb, however, was masked by verlytng paint films of low Pb content and was almost obscured v an overlying paint film of 77 mg/cm-. The results for .vinmercial paint films correlated with chem. analyses but the i infidence limits were too widely separated to allow application i this technique to Pb screening programs. In the field, the ..pparalus was incapable of discriminating between Pb contents <: commercial paint films in theO-li% range. 93340s Use of electron microscope to detect organic phosphate-induced demyelinution. Ezell, W. Bruce, -Jr.; idkins, Theodore R., Jr. (South Carolina Agric. Exp. Stn., Clemson Univ., Ciemson. S. C.). J. Eton. Entomol. 1971, <34t6l, 1345-8 (Eng). Electron microscopy indicated that Mt emyehnation in chicken PERIPHERAL NERVES occurred os iurly as 4 days alter treatment with 1 g TOCP (tri-o-cresyl phosphate I tl) 178-30-81/kg, whereas paralysis was not obsd. s .<il the 10-12tb days posttreatment. 9534It Orgunophospliate degrading enzymes in the crude supernatant fraction from the rat liver. Mtyata, Tadashi; ' latsumur.., p. (Dep. Entomol., Univ. Wisconsin, Madtsim, -'is.l. J. Art. Fond Chem. 1972. 2011). 30-2 (Kr). rour distinctly dillerent type.-, of enzymes which degraded l-XSECTK '1DAL OKGANOPIIOSI'I IATKS in the crude supernne.'it fraction (20,000 g supernatant! of rat liver, were clussdicd an the basts of cofuctor and ion activation characteristics. The enzymes which degraded malaihion 1121-75-51 and parathiun 75-38-21 were detected by the electrophoretic method. ..ectrophoresis treatments did not, however, facilitate the detection of CaJ*- or GSH-siimulatcd enzymes. Most of the ESTERASES detected in rat liver supernatant by using 1-naphthyl acetate did not appear to be important in degrading arganophcisphates. 95342u Urinary afiatoxin U and effects of preservntivca on iU detection. Parpia, H. A. It.; Srcenivusamurihy. V,; Miantha, T.; Shankaratnurti, A.; Srikantin. S.; Amin, 1. (Cent. Food Technol, Res. Inst., Mysore, India). Amur, J, Clin, Nutr, 1972, 25(1), 13-15 (Eng). The suitability of 0 ') V..I .ft, '//. 9.73 18 L i T. ! .,, I |. Clirm Hint Ini i nn I lair. I (1/If, II ll ,,;i/ ,`,li:t lEi.gl An ISOI'VCNIC GRADIENT I E( 'lli\ii(( T! w.-,-, llevi Im|ii'iI |i.r niriisuriug Ihe 111110.1^1111] erosi, linking ol ItNA in 111.1 in til 1111.111 eells niter tre.il inenl with DILI iN< `Tl< )NAL AI.KYI,/.'l 1N(; AGKN'Irt, sueli ns imi^Uinl gov |3l)3-(i()-v| HeLn iclls wire grown lur 3 hr 111 11 medium (oiug 5 liriimodrn- xyuridine 159-14-3] and then resuspended in a medium contg. labeled ihymidnv 150-89-5] to label heavy L)N'A. Treatment, with musurd gns caused covalent chem. honds between the light iiiilnhelcd :iml heavy labeled I)NA, which ;i[i(tenrs a- a sep. rirdiinieiivi immIi or shniihler ol nilermedi.ite d. niter cesium chloride gradient ccnlriliigulion. Moderately high doses of drug must In- used before cross-linking can be readily measured reproducihlv, 95345x Controlling the cytotoxic activity of components of plastics components used in pharmacy. 1. Evaluation of poly (vinyl chloride! and its components using u phytobiologic = nl test. lir/ezicka-Bak, Maria (Zakl. Mater. Med., inst. Lekow, Pol.I, Farm. Pal. 1971, 27(11), 865-71 (Pol). In the presence of poly(mnyl chloride) 19002-86-2] water or alcohol exts., cress (Lepidium sativum) seeds showed, after 4 days, up to 16% slower germination end cress roots up to 31% growth inhibition. Decreases in germination mid mot growth ot up to 16 and 50%, resp., were also obsd. alter exisisure of cress seeds to solus, contg. the polylvinyl chloride) PLASTICIZERS dnsmjctyl phthalate |27554-26-3] and I'lastul Hi, or the STABILIZERS zinc laurate (2452-01-9]. calcium laurate (4696-56-4], and Ergoterm OTCO 116089-37-5). Although the polylvinyl chloride) components used showed interference with germination and growth, further testing is needed before using this phytubiol. test as a criterion in delg. the cytoioxity uf plastic constituents. 95346y Rapid thin-layer chromatographic method for the identification of organophosphotes in blood Pucz. D. M., Faruh, M, (Foe. Cienc. Fis. Quim., Univ. Nac. Cuyo, San Luis, Argent.). Rev. Asoc. Bioquim, Argent. 1971. 30(194-195), 127-31 (Span). Four ml of a sample of blood suspected of s j; ' ItlQlJo----- NOj ^ (WOijPSChCOz l contg. imrathiiin (I) |56-3H-2|, mnJathiim ill) |12l-75-3|, or their mctnlHilitcs puraoxnil 1.(11-17-71 ur nwltinuui 11631-78-21. were txtd. with acidic ethyl ether petroleum ctlicr (3:7). Tliv condensed ext. was chromatographed on silica gel thin layers using either zt-hexane-acelone (6:1) or cyclohexane-acetone- chlo roform 17:2.5:0.5) as developing solvent. S|si(s were revealed using either t-lp-mlrobcnzyl)pyridtnv \ 1 (183-48-31 or hr. onphi no= l blue 1115-39-9] color reagents. The limit' of detection was 1 ppm in blood. 95347z Importance of thin-layer chromatography for the identification in urgent toxicological analysis of 1.4-benzo|f= Idiazcpines used in therapeutic treatment. Lulurguc. Pu-i; Mcunier, -lean; l.euionlcy, Yves iKi. Appl Si-rv. Suute Amices. Hop. Inslr. Amices Vul de (iraci-, I'niis, Kr.). J. Chrumatngr. 1971, 62(3), 423 9 (Fr). Benzodiazepine derivs. Fh hydrochloric arid |7647-0I-U|. i hbira/nrni |li7-(i(i-:t|, Mr air. .57-56-1], and jurmnhn (50-00-01 as urine pn-.-crv.itives lor Silatoxin anal, was examd. Both HCI and torm.ilin were Unsuitable as preservatives u> nionkev urine emitg. undetl oflatuxin 11, (I) |1162-6vVh|, Suvvn JHTVVUl ol UfllK' rom children owl timed allattiKin tlu* i<kmn> ot wlmh was iluid. uy known methods 95343v Thin-layer chrumatoijraphie comparison of Commercially available eiJjr^t coaled films and sheets Mtb silL'u gel coated rIuss plates, demonstrated on Ipiicolo';.. ally interesting sub-dunces Schwedn, I'aul (Otf, Med. Hahimnr'. Md >J (`hinmntu^r. 11)71. <KugJ ( lirnmaf dwi.i (tout com mJo.i I l.iw-fN t.liii' and Id 'r 'iiuv>s* art' tni|Mft d with those i ijttiJ mIhci tel "! pluU-> lor u no of dru^ ol Hunriiny ra;^. relative funmn; rates, so)\cut and mu-r.il ch.ir.it i> ivaic* ol the different incthu tor \KUniUt)MAM)t. .,u upoiii'.i Sti.Mtw Ksliinution of iiihrslruial l)i*A cuts'.linking {CtuLlbg from mustard gas uikvlaliort of Hchu cells Kih. C fiJitw .1 .i Kx- (` 'ir I'* i, M* d pri'seii) in urine vv. re livilrolv/eil |u the eorresponding IlKNZOPI IENONES and UKX.MIYI >1<(),\( lill )1\()NKS. Condensed ether exts. ol the hvdrolv.-is products were ehroinatograplied on nluimna thin layers using iienzene chloroform m (3 () as solvent, and spots were rcvenltd by tluorcscencc or di.i/moiqiling. Depending on which hvdo'l' -is )U"iluels were fleleeled nil the i hriitn.iing. plates, ihe mu, onpiii.dlv1 ingesnd was idetiiiltetl as helottging to I ut me t groups r.nrrfsint i|i 1439-14-31 and mrdit:rpam 12898-12-61. i li/./rdin.-e/iouiie 158-25-3], tlurucrpate 115585-90-7], and i/mrc/juni |604-75-lJ. iiitrazrfinin (146-22-51; or tetraerpam 110379-14-31 Gastric juice iifnz' sharepine hydrolysis products were idem i lied eilhtr )iv llu above lliill lavi-r elirmiiatug. uieiliod. nr hy knuwn s|ieelro|ltniui|neirn urga-i liromaiog. uieilind.s, 95318a Ideutincutioii of roteiinne in fish poisoned by derris root resin Sinna|>]iu. S.: Thnnn. Chang Eng il)ip. Chem , Mimst. Agric. Lands, Petuling laya. Malav.i. Mulinwnui A-' !. 1971. 48(1). 2d I iKngi A METHOD m extg and idem living ralrnaitr (ll 183-79-tl in tish |H,e.oned iiv derris fool resin was described h clone |6V-6!-l| wa us, d tor uln . ud Itiiu laver ebroiiuitog wa, used l,,r ilelo*'on ol 1 tin ,i me OLI 4984 xr 11 fin f*. Vul 7`., | /rj. t* I lane l> A, ndrliuc bundun, 111 A 111 i r , v\ ul lie- biochemistry and mode ul nclieii ul II. thttrin ; .00. ftrotem cryrtol tn\m 7.5 Kefs ' 81812), Thcrmostnhlc exotoxin of Bacillus thnringicnsis Rond. It I*. M , Bnvre, (' II ' , Ih.guff. M, II,; Sim li. I' H. (Mili'ii1.'ul IjiIi <'lif-ni Hn/vinnl,, N`i'll lbs. I.iil Killinglm tirne/Kcnt. Engl.) Mnrolnnl ( utr. Iimrctn 1071. 275-303 (Eng). Edited hv Burges, Hnrcc I) Academic: London, Engl. A REVIEW on the assay, purification, chemistry, and hiul. activity of the rxntnxin; (14 refs. 81813m Effect,) of oxygen upon nphllmlnnc Htnirttircs, Nichols. Chnrles W.; I jimherlM-n. G .1, (Mi ll, Cent , Univ. Pennsylvania, rhilailclpln.i. I'a I / h:thrnnlrr I'h\ - :nl_ I`rnt Svm/i., *llh 1971, f>7 (ill (Knit). Edited hv I ninlicrtsen, Christian ). Academic: New S'orii, N. Y. A L'LYIKW of the physiol, nnd pathol. effects of oxygen (7782-44-71 on ophthalmic structures, such as the cornea nnd lens with 9(3 refs. 8IA14n Modification of the lenf surface and its environment by pollution. Saunders, P. J. W. (Natl. Inst. Agric. Hot., Cambridge, Engl.). F.coi. Leaf Surface Micro-Organisms, 1`rnc. Int, Symp. 1970 (Puh. 1971), 81-9 (Eng). Edit -d by l'rcecc, T. F. Academic: London, Engl. A REVIEW and discussion on the effect of atm. pollution on leaf surface microorganisms, with 39 refs. 8I815p Goals nnd perspectives of toxicology. Fink, Zdenek; Kabos, Jan (Vojen. Lek. Vyzk. Ustav, Univ. J. E. Purkyne, Hradcc Kralove, Czech.). Prac. Lek. 1971, 23(8), 279-84 (Czech). A REVIEW with 9 refs. The necessity of further development of toxicol. is conditioned by increasing use of chems. in the environment. L. J. Urbanek 81816q Toxicological aspects of the utilization of organic tin compounds in poly(vinyl chloride) processing. Wexler, T. (Rom.). Mater. Plant. (Hnrharest) 1971, 8(11), 000 (Rom). A REVIEW with 3 refs, on the toxicity of DIBIJTYLTIN and DIOCTYLTIN DERIVS. used in polytuinyl chloride) (5002-86-2] processing. 81817r Peritoneal dialysis. Review. Mattocks, Albert M.; El-Bnssiouni, Emad A. (Sch. Pharm., Univ, North Carolina, Chapel Hill, N. C.). J. Pharm. Sci. 1971, 60(12), 1767-82 (Eng). The uses of peritoneal dialysis in the treatment of RENAL FAILURE nnd BARBITURATE nnd DRUG POISO= NING nnd in the removal of endogenous nnd exogenous TOXINS were.reviewed. 274 Refs. 81818a Experiment ally induced gastric adenocarcinomas. Stewart, Harold L. (Nall. Canecr lust., Nall. lust. Health, Bcthesdn, Md.). Lab. Invent. 1971, ' 25(6), G72-4 (Eng). The various chem. compds. which, alone or in combination, produce adenocarcinoma of the stomach in cxptl. animals were REVIEWED. Incidence, criteria for diagnosis, nnd different routes of administration in mice, rats, guinea pigs, and hamsters were discussed. 7 Refs. 818191 Thin-layer chromatography of alkylating substances with 4-(4`-nitrobcnzyl)pyridine (NRP). Norpoth, K,; Sehri= ewer, H.; Ratten, H. M, (Hyg.-Inst., Univ. Muenster/Wcstf., Muenster. Ger.). Arcncim.-Fornch. 1971, 21(11), 1718-21 (Ger). Twenty-one compds. were tested for their ability to 0--0N0Z * HC)04 ^ alkylate -f-H'-m(rohrn5yl)pyridme perchlorate (I) |2!>90*94*5) using 7 thin-layer chromatog. pyfitems on silica gel at MO*. Only cyclophosphamide (50-18*0) and its analog, :i-(2-chlnrorthyl)-2-= (2-chlontfthylamino)tctrahydrt}`2ti-l,3,2-oxQiaphnsphonnf* 2 o\idc 13778-73*21. had the same profile. Tlie^e 2 compds. could not he invt"lij:nt<,d hv paper Hiromiitoj;. nthor The sensitivity of this thin Inver chromalng. system to ('I1LOU' OKTMMsAMINK CnMl'DS, ivhh chroniatti*'., or sptriroM'opti' mini ihnn that of p:i|WT tenant, rvidu.iiion hy chromatogram speetro* ropv min heptt -,ilIc Adsorption of polviddorinutod hiphcnyhi (IM'Ill on gln'.s ?;iirfm`r`s Ihiliula, Marja I,; Korin;', t) (liv-t, I'imrmnt <>( Inxirol., |{ Wf, Aj-.rir. 1'mv,, <`ppoidiiif*i,M. Ilrn.l, l)nn< 7 id-sir hi mi 1071, 4fW7i. 2.VMH (Kn.), Annl. mr.'rairenifnt of pof\rhli>nnntrd hiphmyts is hindered hy a Mnut*' adsorption of POt from wnlcr solos to glrn'i surfaces. In' ignihri'li.t nd"orption, however, was f>h ;d, wh^n aluminum !712!)-*Jfhr| ront/iiners v/'-re used. Adsorption was higher onto older ghus than onto silicon* coated new gloss, hut adsorption ?.as still significant in storage vessels. 81S21n "Rapid method of determination of barbiturates in hiolcrdcamcidir. 'Ronrioux, J. M.; Armand, J.; Bernon, H.; Badm'-.od. A. (Lah. Cent. Chim. Biol. A, Hop. Edouard-Hcr^ riot, i/.ons, Fr.). Bull. Trav. Soc. I*harm. Lyon 1971, 15(1), 3-12 (.t) A rapid (20 min), highly reproducible method for detg. h!rad barbiturate levels was described. The method involved chchlnmethane (1300*21*61 ond NoOH extractions; for r8r-. bnrh.tu.Ttnx . thn rnmn n-f r--it nf r-i.-rti,-- ,.-.i...vmy tin- iiplitnl ilriiMlir, ill ' mv ' pri Ir.'l iilil.'imril lit '/l|l| p pH's ill ID ami i:i,5. 'I lie I'rrur invuLcd in the mc'h(lrrn':i'.i`(l when results were expressed :,s gmnlcs/l. rat Ik ns mg/l, 8l8.!:'p Stability of rat liver rihimucleir acid in viv- melhvlntiun with methvl melbancsulfiinnle or dimet' ronnminc. MeElbune, M.irilvn .1.; O'Cunnur, I1, J.: Cl W. (i'ntcrson l-ih., Christie Hosp. nnd Hi.it Rndiutr Manchester, Engl,). Rinrhem. J. 1971, 125(3), 821-7 The half-life of the rale of disappearance of '"G ! 7 tnethvlpmntine (978-76-71 (rum HNA isulaled from the i rats trealeil wtlh eillier "C labeled rnt'lhvl mi'tltnnenn |6G-27-3| Cl mg/kg) was ---(lavs 'I iie esld. hint. HAL! ()F IlNA using 'II labeled iirnin- anil 165-86-11 was ' Kcutilizntion of labeled UNA degradation products fo orotic acid-'H may result in an overestimation of the h; Non-toxic doses of the methylating agents may provide i. measure for cstg. the biol. turnover of rat liver ItNA than orotic arid. 818231, Unconclatcd thin layer chromatographic a for the identification of basic drugs. Smnlldnn, K. W. Counties Forensic Sci. Lab,, Aldermaston/Bcrkshire, Forennic Sci. Soc., J. 1971. 11(3), 171-6 (Eng). The H for 50 relatively common basic drugs having NONPHL H1AZ1NE BASES were detd. in 5 chromatographic f using Merck PRECOATED PLATES. In the choice of (hi chromatog. systems for use combinations, a compromise t made between ideal R, frequency distributions or correlation coefficients. 81824r Detecting tubocurarine in Lssue. Stevens, Fox. R. H. (Home Off. CenL Res. Establ.. Aldermasto ding/Berkshire, Engl.). Forennic Sci. Soc., J 1971. 177-82 (Eng). The method used for thi extn. of d-tubnc (I) (57-94-31 from LIVER tissue con- sted of protein n alkylation of the soln., nnd removal of intc-i'ring b.shoking with dirhlnrometnaric |75-09-21. I couid then I and estimated by uv spectrophotometry. Thymine [> and tyramine (51-67-21. 2 commonly occurring putrproducts in liver tissue, rould be sepd. from 1, hy a thr chromatog. system using Merck precoated alumina plates 81825s Determination of arsenic in coal and in insec by ntomic absorption sr-ctroscop.v Spielho>t/., Gc'loralhnlla, Gloria C.`. Steinberg, Knlph J. (Herbert H. 1 Coll., City Univ, New York, Itrunx. N. Y ), Mihrmlm 1971, (6), 918 !'.l (Eng). I'..Mowing lie. rierompn of org in coal and inserticides hy V. KT COMBUSTION with pc acid plus periodic acid, am. oic (74tn-58-2) could he detd absorption spectroscopy. The method was rui.id and ei, and no loss occurred by VOLATILIZATION during prepn. The sensitivity of the method v.-as enhanced over the normal aspiration technique by utilizing the samplu ncces,-or>. 818261 Diochemicnl screening test with |IJC|-glucc P'PI-phospbatc for the evaluation cf embryotoxic tfi vivo. Krowke. Rolf: Siebert, Gabriele: Neubert. (Pharmakol. Inst.. Frcien Univ. Berlin. Berlin, Naimyn-Schmirdebergn Arch. Pharmakol. 1971, 271(3), (Eng). Embryotoxic effects of drugs were screened b. with the i.v. injection of "C-labeled glucone (50-i JJP-lnholed phonphnte 114265-44-2] inui various cxptl. a: These unspecific precursors were incorporated into n vn. acid-insol. cell comimnents by various mctsbolie pathwn did not induce an alteration in the concn. of anv intermediary products of CELL METABOLISM. The r. tivity of incorporated lipids, RNA, glvcosnminoglytan'. and proteins was measured, using a simple frruP procedure and a double labelling teebnupie. The apple anil limitalionsortbis METHOD were de i ussed. 81827ii Drlerminiilion of bis(p-ehl(irophenvl)ncrlie i urine Kreelnuak, .ler/v; Iiiibrawski. Kapuunrl (Zal I 'I'likavkul , Atad Med Gdansk, Gdansk. Ibil.l. i* Chan. Tokwl.o.' 1971, 4(31. :'8I 5 (I' d) Tie lih'r | mctnliolite, hin(p-ehlornphrn\l)acvtic orid (U 8', [)"i-6|, in rnt and human urine samples, was freed hv h>nr, extd. with ethyl ether. Alter purification hy reexm. . NnOH solns.. 1 was detd. hy the method of Fcl.rvl,- Haller. Recovery of I from animal and human i.nne i was 98 nnd 94%, resp. 'n human subjects who w professionally exposed to DDT, a mean value of 0.05 ; unne was detected. H!82Rv 'Fractionation of coral frake veno.v. P-r and characterization of the prot in fractions, i M-v--rdV , f', ..If 1- , l,,- IV OLI 4985 :i;c . cl.,,,, 'I, hlK't" V.d Vo. 197;: rj Png turn- l\p, 4 "l HU,L(L.||1-|1 tut" Ih.-.-iptl p - I. i , w.-ie ipiinht. ........... .it, ah snpph , ,ni,,nt .-im-ui <.1 t' liiiipicts, ;i III1 dll' tlli'lln'il Ilf i.nill'in. CO VII III l li-1II-III I" ' i llll.irily mi {.trim . i]i 11 j|tii * ii il tin' ii .H linn l* 11 11 . t i- , dii . ,i ilnliiv <if 1 1 III |l It 11'11 III I I Ml i'l in'll I . I 11 it )'I'III I I I i llli- Imd i' i Ii*. III II -cnlcil i iiln11 id mi lit dn l `I 1 t iim II. J i .i* 'n I i - .il H. 1' I 'f - 9.5 9.7' , . Prior 1 o i`(|inl. I In mac- > n-lil was -- (Of g t`i - g i harvoal consumed. 76Qb8t Absorption and emission by sulfur dioxide between 1050 anil HOG cm Burch, li.im-ll 1C; Pcnihronk, John 1).; Grvvnak, Iiacitl A- (Aci ntmtriin. Ihv., l'liilt n-l-oril Corn,, New pm l Beach, c.ilif.t G.S. A'at, 'Pah. Inform. Serv., PP Rep. 1<)7I, Nn. ;|ii3522, 5b |i|i. (I'`iij;). Avail. N'l IS. l-rom (iovt. t\t /'. , t nooottf e. (l ..V.) 1071, 71 (J3), lU't. 1 he nhmrfi. lion by the n (1151.38 vin ') .mil ip (1301,70 fin'1) bands of SO: was studied between 10511 and 1400 cm1. Spectral curves oi transmittance were scanned with --l cm " resolution for >200 samples varying in temp, from --290 to 5T5K and in pressure from 0.01 to 10 atm. The objective was to provide data on SO: absorption and emission that arc required to inter pret data obtained in tins spectral interval on the emission by smokestack exhausts contg. SOj. An extensive table pro vides information from whicli the emission between 1050 and 1250 cm'1 can be ealed. for temps, between 290 and 650K. Water vapor absorbs and emits so Strongly in the region of the si hand of SOi that this band is probably not useful for remote sensing of smokestacks. Therefore, the tt band was empha sized. The strengths of the 2 prominent bands in mols. are: vj, (371 = 20) X 10" and n, 3020 200) X 10. 7606<>u Induced radioactivity. II. Air and water con tamination. C,oebcl, K.; Prantl, Priederike; Stevenson. G. R.; Vialcttcs, 11. (Undiat. Group, CERN, Geneva, Switz.), CERN IP.ur. Orgon. And, Acs.) (Aep.j 1971, CERN 71-21, 11G-2C) (Eng). Radiation problems arising from activation of the water used for cooling magnets, radio-frequency cavities, targets, and beam dumps is discussed. The extent of soil and ground water activation near the accelerator site is estd. Ests. arc also made of airborne activity in the form of dust and radio isotopes produced in the air. W. W. Ilrown 76070n Morning vehicle-start effects on photochemical smog. Martinez, J. It.; Nordsieck, R. A.; Eschenroeder, A. (), (Gen. Res. Corp., Santa Barbara, Calif.). V.S. Nat. Tech. Inform. SrrvPIS Rrj). 1971, No. 203872, 41 pp, (Eng). Avail. NTIS. Prom Govt. Rep. Announce. (U.S.) 1971, 71(24), 113. The influence of cold-start vehicle emissions on air quality is investigated using a photochem./diffusion model. Both the time and space distribution of cold starts are examd. Emis sions iuliiiilui ed during I lie ..i.irling process have the greatest effect of nil on C< I peaks, the clb-i I being, to increase the peak CO coucu. from 9 lo I.'!'j,. The levels of Oj and NOj that Imild up later in the day arc influenced less liecause ebem. processes afford dilu. time. If vehicle starts are decentralized gcog., only a slight increase in tlie pollutant loading is noted because of the low morning speeds. Three possible weighting schemes arc proposed for combining cold-start and hot start driving cycles. 76071p Catalytic control of NO, emissions from mobile sources. Seegnlt, Manfred I.; Napier, James C.; Compton, William A. (Solar, San Diego, Calif.). U..S. Nat. Tech. Inform. Sere., PB Rep. 1971, No. 204011, 142 pp. (Eng). Avail. NTIS. Prom Govt, Rep. Announce. tU.S.) 1971, 71(24), 116. The project investigated the use of various catalytic media to control N oxide emissions from motor vehicles. Lab. tests of various compds. were conducted. The compds. tested included rare earth oxides, Pt, I'd, Cu dichromate, and modified Monels. The modified Monel compds. were most effective in reducing N oxides. 76072q Fuel additives and automobile exhaust emissions. Pinning, R. !>.; Marshall, W. P.: Allsup, J. R. (Energy lies. Cent., Itiir. Mine-., Ikirllesville, Okla.k //..V. Not. Teth. Inform.-Sere., I'li AV/>. 1**71, No, 2113891, 15 pp. (Pur 1. Avail. N1IS. l-roiii Govt. Rep. Aonooo.e. (/ \.x A 1 '>71, 71(2-1). 1S2. The nillticucc of fuel mldilii es on c\hnu-t emi-.-miw was studied using aiitotuoliw engines emrcnllv found in the I'.S. vehicle population. The fug] additives used were 4 multifunctional additives and one I'll antiknock additive. No significant direct effect on c ii.uist etuis.inns was hiuud for I lit- mull ifunetinnal additives le-leil. \t o, di-lvigenl-dispcrsnut additives had little influence on ettu-sions when Used in conjunction with high- quality oil and motor fuel. The KtiPb antiknock additive in- ireased c\h -.list l.ydrocatlions -- 12-17% during a 4999-mile accumulation period using a base fuel contg. 2 ml of P.t,Pb/gal. An imleatled fuel was u-cil during a similar accumulation period with no imr-msc in eshaust hydrocarbons with mileage. 70073r Exposure of marigold fTagetes) to gaseous hydrogen chloride. laud, Christopher T.: Loudon, Sheldon A. (Acrosp. Med, Kes. 1 ..ib., Wrieht-Pattcrson Air 1`orce Base, Ohio). U..S. Nut. Teeh. Inform. Sen-., AD Rep. 1971, No, 732190, 18 pp. (En ). Avail. NTIS. l-rom (Tor t. Rep. Announce. (U.S.) 1971, 71i21), 81. To ascertain the extent of environmental pollution problems attendant with Air l-'orce missile operations, malun Dowering tnitigobl plant-, were exposed to one t known exhaust products, 11 Cl. All plants died after 5 m pietiri- to '971 ppm, the hiihcst loncn, used. At 95 pt i-tti-i I w-.i-. lulled. .`..-eils olil.niied f i oi ii the exposed plan not appi ar I o In* a ft i-i teil 11 v the 11 Cl t real nielli. 70074s Automated instruments in air pollution moni systems. Thiele, Itevan R. tUiv. Air Pollut. Control, Health, Brisbane, Aust.). Clean Air (Heidelberg, Aust.) 5(4). 95-79 (Eng). A detailed account is given of nir pol monitoring systems, and their application to the Alts1 tit ban situation. W. Sir. 7fi07St Possihle effects of nircraft flying in tho stratos- Bigg. E k. (I)iv. It.nliuphys., CSlItO, lipping, Aust.). Air Uleuh Iherg, A uA I 1071, 5(4), 57-9 (ling). Particle- been collected at heights between the ground and 40 km Australia. Particles >0.1 pm arc confined to 15-25 km, ' mean of 9.3 pin anti a max. size of 2 pm, and this layer is < wide. In general these particles are (NHi)jSOi, but : droplets have predominated following the volcanic erupt! Bali in 19G3. In the 0-10 km layer in Central Australia (1 SO, predominates. High flying supersonic aircraft will . water vapor into the 22-km layer and cause swelling of thr droplets, leading to either greater deposition rates or more scattering, or both. W. Stra 76076u Infrared spectrographic technique for analysis c products from gas-fired appliances. DeWerth, Dougla (American Gas Assoc., Inc., New York, X.Y.). Atncr Ass., Oper. Sect., Proc. 1971, D45-D48 (Eng). A disper:' spectrophotometer set-up with an absorption spectrum rat. 2.5-25 it can be used to det. directly and rapidly trace cone NO, NO-, SOi, CO, CH., C:Hi, and total aldehydes it. gases of gas-fired home appliances. Gas anal, results can I produced with an error <1%; NOi and SOi results agree t with wet cliem. checks. 76077v Removal of dust and fumes from waste g Lancashire, R. (Process Eng. Div., Newton Ciiambcrs Ltd., Thorncliffe/ChapcHown/Sheffieli.'., Engl.). Environ, tut. Manage. 1971, 1(1), 29 31 (Eng); Efficient cleann 99.9%) of waste gases at inlet conens. <5872 mg/in1 can i tained by the use of a high-energy (pre-ure drop of 50-300, water) Venturi scrubber (annular clearance washer) which sists of a single large Venturi tube in whicli an axially adjm displacement cone is fitted to form the gap through whir! dust laden gases pass at high velocities. A system requiru most no make-up water is described and can clean <3 tan du min produced during O blowing in a 200 ton converter. 76078w Activated enrhon adsorption processes for previ nir pollution. Kiill, llrlinni, Slurp, Man; (l.tngi Wa nnii Chcinolcih. m.b.ll,, IT.mkfurt, Gi-r.h Environ. ! Manage. 1971, 1(1), 8-15 (Eng). A diwuxsion is given o production, by gas nml cliem. activation processes, of v. grades of activated C and their utilization in waste and ex' gas purification in the Supersorbon, Sulfnsorhou, and Sul processes. Plow diagrams are given for the 3 processes tor with cleanup efficiencies and S recoveries attained in v. plants (by the Sulfosorbon proi ess) and in waste gas desulfi, tion (by the Sulfreen process). 760791 ^twriling xuayl ahlnride emargeuckw. Dowell L. (B. F.Tlooffrich Chem. Co.. Cleveland, Ohio). Loss VKlt`5, 29-31 (En;;). The potential hazards from the accir' loss and combustion of tank car amts, of vinyl chloride moi. (VCM) are discussed, and procedures for handling VCM car and marine transport emergencies are listed. Mon indicated that the burning of VCM under sp. conditions mixed witli O) can produce a phosgene conen. of 20-40 ppn in tank car loads (290,000 lb) would produce a ground levc. conen. of 5 ppm to a distance of 10,000 ft. 76080r Specific method for the determination of ozoi flic atmosphere. Smlidev, Sh.uu 1,,; laidge, J. I'., Jr.; ' I'Uilip \V. (('nates t'ln-m. 1 , l.nnisi.in.i State t'niv., i1 Knin-.e, I.;,.). Anal. Cltio:. Aita (072. 5S( 1), 141 7 ti A simple, M-initive. ami spe,ilic method for tin- detn. of Oj i atm. is ileccribed. Ucaclions of Oi with several 1-alkcncstudied at 25. Eugeiiol, when treated with Oj, was fot: produce relatively large amt-., of 1ICHO compared to oti alkenes tested. The method ib-seribcd was emupared wit' illk, iodiile method for the detn. of various eom-iis. of Oj t range 9.95 2.9 ppm. lljO*. (w-racclii- acid. SOj, and varm dining agents eomniouly jirescnt in the air. do not inti I Id 10, when present in tlic nir. must he detd. sinmltam and the conen. of HCIfO subtracted from that of the Oj. HCHO monitoring equipment can be easily adapti ! for tl of O,. 76081b Bromine and chlorine loss from lead halid.- mobile exhaust particulates. Robbins, John A.; Suite, i i. L. (Dep, Environ. 1ml. Health, I'niv. Miihignu, Ann / Mich.). Environ. Sri. Tcchnol. 1972, 0(2). Hit 9 (Eng-, automobile exhaust particulate matter introduced into a transparent, outdoor enclosure was analyzed for Br and t neutron activation anal, ami for I'b clcctroehem. Parin' OLI 4986 vital ^cd. iwi, 'inds i r,.....i V..I -.i;. ruv 7- W'.H.'K |.'i mu, ?11, x 1 i h*- /mi*1 widened v.-illi increii .rd d**.i;H\ ' `d A()i i\ 1H m piwum.w convoluted U'-.ul.ir <,p1tlo !. on ,{,,1 no; dun i In-tv*.u saline tfeated runlrnl iM.ui.i-K and 0- ,> ihIUm doe^-v ol` U-,01 !> day 1 jk Uhji.'Umit .dutea h\ mV pi^ t.ulii.iia -I i at n-ii ol the liidil vi Ihmvv I i;:` I, d"-r tin1 i.uan jus; ol li.ito:ev jot fjrJd m poisunrJ Ki*lnev,s was 8- sold 10 timer, ^ircifr than llial Jnr t)>r rouiofc. Mit'*ue nrliviiy J. neaped in beth calcfjoriua of Hfil'I. iituimcnt by Huy ,t. One day loliovvinj' llj',01^ irijivlioa, M-NOllON w.is deertv"(-d to Ki'd tlie.- normal function. whereas on day *J </ day 3 pcv.hnju.tion, kidney function increased to 15 and 717c of therontio] value. CS827/ l'olc of the microsomal electron transport system in the hri'atctoxicily of carbon tetrachloride and ethanol- [j'Cunnnr, Mane h. '(Johns Hopkins Univ., Baltimore, Md.) |f>7i. 11a pp. (J*2nni- Avail- Univ. Microfilms, Ann Arbor, Mieb., Older No. 71-21U5G. From Hiss. Ahr-lr. hit. 13 1071, GKftUKa Comparison of cerebral toxicity of monomeric and trimeric forms of sodium iotbolamute. Dousl, Bruce !).; Fischer, Horry W. (Hep. Radiol., Wayne Cty. Gen. Hosp., ftloi&e, Mich.). Brit* J. Radial. 1971, 44(526), 764-6 (Eng), CO?No SO,So I effect was shown following 1 feeding for 78 weeks. G8833y Cytotoxic effect of fusidin in tissue culture. Gerasimova, i5. S.; Berezina, E. K.; Blvumkin, V. N, (All-Union Res. Inst. Antibiot., Moscow. USSR). Antibiotiki (Moscow) 1971, 16(11), 1003-6 (Russ). Na fusidin (1) 1751-94-01 at 10, 50, or 100 ue ml had no cytotoxic cflccts on chick embryo fibroblast cultures or transplantable monkey VERO cells in vitro. I at >2(Xi i>g/ml prevented further formation of the CELLULAR MUNOl.AYElt nod gradually destroyed the preformed cellular layer. 088347. Effect of carbon monoxide inhalation on in vivo drug metabolism in the rat. Montgomery, Mark R.; Rubin, Robert J. (Sch. Hye. Public Health, Johns Hopkins Univ., Baltimore, Md.l. J. Pharmacol. Exp. Ther. 1971, 179(3), 465-73 (Eng). Preexposure to 1000 or 250 ppm carbon monoxide (630-08-0) inhalation for 90 min inhibited the in vivo No iotlialamate II) (1225-20-31 <0.2 and 0.4 ml/kg; 300 mg metabolism of hexobarbital (50-09-9) and xoxozolomine (I) iodine 17553-56-21/ml) injected into the common carotid artery 161-80-3), regp., by rats in room air. Exposure to the same CO of dogs had less CEREBRAL TOXICIT)' (pulse rate, blood levels for 90 min followed by drug testing in the CO environment pressure) than a soln. of A'fl iolhalamalc (rimer [34280-40-51 of significantly enhanced the CO-induced effect. The prolongation the same iodine concn. The difference in toxicity may be due to of the pharmacol. responses may result from a CO-induced the difference in the osmotic activity of the 2 CONTRAST inhibition of the HEPATIC MIXED FUNCTION OX1DASF, MEDIA. ENZYME SYSTEM responsible for the metabolism of these 68829b Metabolic reactions in an organism during chronic compds. Inhalation of atmospheres containing lowered oxygen carbon monoxide intoxication- Datscnko, 1. 1. (USSR). [7782-44-7] concns. bIso inhibited I metabolism. Fahtory Vnesh. Sredy Ikh Z.nachenie Z.doroe'yo Is'aseleniyo. 68835a Effect of peroral administration of dioctyltin and Rcsp, Mczhved. Sb. 1870, No. 2, 146-0 (Russ). From Ref. dibenzyltin bislisooctylthioglycolatcs) on rats. II. Effect on Zh,, Biol. Khim. 1971, Abstr. No. 5F2054. Rats and guinea pigs the animals' fertility and the development of fetuses. Mazur. exposed to carbon monoxide [630-0S-0) (0.009-0.018, 0.030-0.040, Halina (Zakl. Badania Zywn. Przedtniotow Uzytku, Panstw. and 0.08-0.1 mg/1, air) for 1.5-3 months showed an increase in Zakl. Hig., Warsaw, Pol.). Rocx. Panstic. Zakl. Hig. 1971, blood cholesterol (37-88-5) levels during the early stages of 22(5). 509-18 (Pol). Female rats receiving the poly (vinyl poisoning and at low CO concns. No changes in hemaloi. chloride) [9002-86-2) stabilizer, dioctyltin bis[isooctyUhioglyc= indexes were olisd., hut carboxylicniriglubin was detected in the olate) |2640l-97-8| (20 or 40 mg/kg) before conception or during blood. CO may promote the development of ATHERQSCL= pregnancy, showed about 17% incidence of dead fetuses. No EROSIS. dead fetuses were obsd. in female rats receiving dibenzyfim 68830v Effect of qualitatively different proteins on some bislisooctylthioglycolote] [28675-83-4] (18 or 90 mg/kg). and the biochemical blood indexes of animals exposed to the action of no. of resorptions increased only at the higher dose. No elemental sulfur. Kuziv, R. S.; AJcksevich, Ya. 1. (USSR). differences w-ere found in the process of skeletal ossification Fahtory Vnesh. Seedy Znachenie Ikh Zdorov'ya IVaseleniya Reap. between fetuses ofstabilizer-treated females and controls. Mezhved. Sb. 1970. No. 2, 51-5 (Russ). From Ref. Zh., Biol. 68836b Effect of long-term peroral administration of dioctyl Khim. 1971, Abstr. No 6F2057. Lengthy (4 month) administr= and dibutyl phtbalates on rats. 111. Effect on fertility and ation of elemental sulfur [7701-34-91 (9.3 mg'kg, daily) into the fetal development. Piekacz. Hanna (Zakl. Badania Zywn. stomach of rats caused a decrease in blood catalase and Przedtniotow Uxvtku, Panstw. Zakl. Hie.. Warsaw, Pol.). peroxidase activities and in blood SU-group concn. The total Rocx. Panstic. Zakl. Hig. |97L 22(5), 519-26 (Pol). PROTEIN, albumin, and globulin levels in the blood changed Among female rata receiving dioctyl phthalate (1) [117-81-71 or very little. Casein, when added to the rations, standardized the dibutyl phthalate [84-74-21, at 1% or 5% ol LDw before biochcm. indexes, probably by decreasing intoxication. The conception and during pregnancy, the animals receiving the addn. of soybean protein or meat was less effective. higher dose of dibutyl phthalate showed the smallest incidence 68831w Toxicity of plasticized and nonplasticized polyfvinyl of live fetuses. In the rats receiving lethal dose of I or 5% LDvi > chloride) extracts, stabilized with ethyl L-rotonatc. Spurn, A.; Cirstce, Adriana; Dinu, lleana; Boghianu, Liana; Ghizetea, dose of dibutyl phthalate. decrease in the wt. of fetuses was also obsd. No impairment of ossification was noticed in the fetuses Gabrieia; Ozeranschi, Lucia; Botescu. Elena (Inst. lg. of the treated females. Sanatatc Public*, Bucharest, Rom.), tgieno 1971. 20(6), 68837c Influence of cadmium on bone salt metabolism. 323-30 (Rom). El crolonate (g) ||0S44-G3-S| leached Iron) liirutu, Masfiioslii (Sch. Med., Gifu Univ., Gifu, Japan). (li/ii lhngid.il Iguhiihii l\i\<> 1971, 19(1), fi'4 1)5 (Jniinii). Ciidniinm (741(1-43-91 C.hxi ppm) mrmi-isl MTUm miauni urCH.'CHCty t | 1744(1-70-2) mu) ulkuhne idin\i*hnttt*e ns well ns tirinnrv Cn mid phosphorus [7723-14-0) bul itrt-rrasod scrum I'. Allcr irculinriit with Cd for 1 year. OSTEOMALACIA AND OSTEOPOROSIS were obsd. lead [7439-92-11 increased scrum Ca and P and I-Stabilixed poly (vinyl chloride) (PVC) [9002-86-21 showed low urinary Ca, while decreasing serum alk. phosphatase and urinary TOXICITY. Lxte.. obtained by soaking l-contg. I'VC in water P. F. Koide for 2 months, given orally in young mice slightly impaired the 68838d Selenium and tellurium in rats. EfTcct on growth, growth and slightly depressed the serum acid phosphatase and survival, and tumors. Srhmcdcr. Henry A.; Milchencr, succtr.ic dehydroernasr activities. Marian (Dep. physiol,, Dartmouth Med. Sch.. Hanover. N. 63-32x Toxicity of the food dvc nmnrnt.ih. Galea, V.; H.). J. Sutr. 1971. 101(11), 1531-40 (Eng). Among rats Pri'vii. N.; i'.*;1 . !*.r.iir,. t-- b , t- m .1, b T< ,.ri,l . Ir.sT. receivin'.' drur: scVno/r f 13110-01-f)L sodium - Med. Kj'm., i'l i. Rom.). t:n-j 1571. ?.lo'o 331 u illomi. [ltil02-l8-8(. or sodium tellurite [10102-20-21. at 2 ppm ne or ic Ihc MKHl J)YK f:'n,.rnn!h (II (0)5-li7-.'R prt.su.i.- some ch-ooie lor 1 year ai'cr time hi weaning, and at 3 ppm Sv or 2 ppm Te TOXIt'l l'Y. l(si ud 3d n-- l day On 7n w-- ks showed 2% until natural ucath, selennc-trcaied animals showed hmncsi murtahty ,-s eor.,p:.red to 137, (or controls I reduced in tlie !i-.cr suppression of growth and mortality. In the latter group. 5d 7 of the \ 1TAMIN A tontent. and induced histochem modifiratinas. the males were dead at SS days of age. Selenate and icliuritc 1 feeding for td cays increased the glutamic-oxaloeettc were not toxic in terms of growth, survival, and longevity. In transaminose activities in the scrum and liver, and the Se-fcd animals, accumulation of Sc in organs was more man glutamic-pyruvic transaminr.se activity in the liver. No such f. ' / OLI 4987 i f !tii t u> > i</ \\\ ):ii` : i*> * i, r/'iMM' <> nt |m; r.i, i>jr nmi rhih,,h, ,, ,<i |v. r.i :i| i u. i.Mitli'i u 1 u , l' im*l ) i'.K'A I U< i i\\H * I I *' 1 ,<' 1' wSuii irn* * i i ft In |*i i mui' 1`Mi'aIi (}-.V-'lVliji1i\illtM'.Mitj.iliinui Tv.u imwl in vilio M:i\n.utl. h, l`i , 'inim, <>., I'llWii-r, i{ li.I Kit'rslrn'l, |{. W, tClium. !(<,. I)*|i, linllnunn l..i KmiIh lu`\. Nulkv, N. . ). b\p,nmlni |!i/|, LMlu), ||M iKn,-). j. am, e' o II. (nOu, '" I'-Hydroxy-S1- telrohydiocaimahinnl (11 [33NS6-01-3) ami 3`-hydruxy-y-letrohydrocannabinol (III ('S:iSNG-05--lj were identified as metabolites of (-)-y~ tetrahydrocannabinol [1972-07-21 following aerobic incubation with the 9,000 g supernatant fraction of male dog liver. 42469j Changes in microsomal lipids of rat liver after chronic carbon tetrachloride intoxication. Comporti. M.; Landucci. G., Raja, F. (1st. Palo). Gen,, Univ. Pisa, Pisa, Italy). Experientia 1971, 27(10), 1155-6 (Eng), Chronic HH(CM,lwCOjH ) carbon tetrachloride (56-23-5) treatment of rats caused an enlargement, severe cirrhosis, and a massive fatty infiltration of their livers The HEPATIC TRIGLYCERIDE CONCN. was increased in the CCL-treated group. Also, fatty acid changes occurred in liver microsomal phospholipids; stearic acid (l) [57-H-4], orachidomc acid {506-32-11. and docoxnhciaennic acid [25167-62-8] content decreased, while that of palmitic acid [57-10-3). palmitolcic acid 1373-49-91, and oleic acid (112-80-1 ] ' increased. Phospholipids of microsomos from CC1.-treated rats contained smaller amts, of 1, linolcic, orachidomc, and docosahexacnoic acids compared to those of control animals. The larger decrement was found in docosohexacnoic acid and the lower one in hnolcic acid (60-33-3], PEROXIDATIVE DECOMPN. of lipids of the endoplasmic reticulum may persist after prolonged treatment with the poison, 42470c Experimental lathyrism. Inhibition of d-alanine incorporation by d-aminopropionitri)c. Alro, J.J.; Cammara= ta, A, (Sch. Dent., Temple Univ., Philadelphia, Pa.). Experientia 1971, 27(10), 1161-2 (Eng). The lathyrogen, H^CHfCHjCN i fr-aminopropionitnle (I) [151-18-81. inhibited the incorporation of structurally similar 8-alanine (107-93-9) into L-929 fibroblasts cells in vitro, suggesting that a degree of competition existed between the 2; however, the effect of I was not truly proportional to the (S-alaninc over a wide range of cunens. 3-Alanine failed to reverse the effect of I on cell growth. Lathyrogens may act as antimetabolites competing with a norma) analog for incorporation into developing connective tissues at one or more stages of mctaliolism. 4247 Id Liver damage bv protracted ethanol uptake and its reversibility. Turclietto, E,; Cabnni, L.; Co&tantino Lupi, M. P.; Formiggini, E. (1st. Chim.'Biol., Univ. Bologna, Bologna, Italy). Experientia 1971, 27(10), 1167-8 (Eng). Following treatment of rats with 10 or 20% ethanol (64-17-5) in their drinking water for 2 weeks, the biochem. damage induced in LIVER PHOSPHOLIPIDS may be more severe than the accumulation of NEUTRAL FATS, and 2 weeks after the treatment ended, an appreciable reversal of the hiochem. pattern was seen, especially in the 10% KlOll-trcnird group. Liver phospholipid fractions, such as LYSULKCITHIN. SPHINGOM YELIN, PHOSPHATIDYLCHOLINE. P!10S!*HAT1I)YI.KTHA= NOLAMINK. PHOSPHAT1DYUNOS1TOL. PHOSPHATIIlYLSKRINE. and CARDlOl JP1N were greatly increased in conen. immediately after cessation of the treatment, while 2 weeks later the values were near normal. 42472c Effect of cerium on drug-metabolizing activity in rat liver. Arvcln, P.; Karki, N. T, (Dip Pharmacol., Univ. Oulu, Oulu, Finland). Experientia 1971. 27(10), 1189-90 (Engl. On the 3rd day after a single i.v. injection of cerium chlur.de <2 mg Oc/kgl into rat*, liver ho.,ii<irii.,'.'e.- Inn ihr ,`n"" m ex:di.'.'d h- t'.r `-o/.o.-t ;.",o-ii;<-ol a;,,l c.-om ; h*. l.Uit:-V-'I;.;..', . Mic [IOiWil-aj at r.iiti wliicii were II and f'j. : p.. <i the corresponding cuntenl value*. On the -;u.,e day. (he i^ti.i-hnnie P-liO content of the liver was 5:>7r uf the control level, and blood glucose [30-99-71 was 52% of control. The metabolic liini (nr;', notiiiaho'd willmi Pi d iv lY/itnii uwiv ml* tail wnl. Mb 'li( K< IM Al. I't 11 iSl`11111,11`IDS winch nre iieedeil lur II, hiniMionini; "I i vtm lirnim I' -lull, nr j] may ntilngtuii/c Mg nud (hi cl 11 III Ml e infill ill llruj; In rl ahnli sill. I2(73f Arinin of powderril mi-liibili/ril pnlvt'lbvlinr Nil iiml iiulypinpvlcne on iinittmU Slivetb briikn, V, S. (USSlil tlig. li,/i. /Vuk'ciu/, 1`nineu. I'ult/n, Muter. 1969, 104-12 (Ituss). Musk. Naneh Ksled. Inst. Gig.; Moscow, USSR. Powdered polyethylene Nil uttd polypropylene [9003-07-0) giver, in a single oral dose (3-7 g/kg) to mice, or in a singk intratracheal dost of 50 ing to white rats, or inhaled (1(g) mg/m1) for 9 months by rats and rabbits showed weak TOXIC EFFECTS revealed in bronchitis, peribronchitis, bronchiolitis and n weak diffused sclerosis of the lungs. A conen. of 8 tnu/m1 is considered as admissible for the factory buildings. 42474g Toxicity of a polymer cement coating based on hutadicne-styrenc latex for water pipes. Lasgochkina. K. O. (USSR). Gig. Vop. Proizvod. Primen. Polim, Mater. 1969. 163-9 (Russ), Mosk. Nauch.-Issled. Inst. Gig.: Moscow, USSR. Long-term tests showed that cast iron pipes coated with a polymer cement coating (based on butadtene-styrene copolymer |9003-55-8) LATEX) could be used in water supply systems after CONTINUOUS RINSING for 16 days. A significant increase in OXIDIZABILITY was obsd. following a 4-day storage of water in the pipea, although styrene or butadiene were not detected in the water. 42475h Toxicity of a composite waterproofing coating based on chlorinated polytvinyl chloride) in water supply systems. Znmyslova, S. D.; Kudrin, L. V, (USSR). Gif. vop. 1`roizvod. I'rimen, Polim. Mater. 1969, 182-8 (Russ). Mosk. Nauch.-Issled. Inst. Gig.: Moscow, USSR. Long-term tests showed that a composite chlorinated polytoinyl chloride) [9002-86-21 coating (conlg. crushed CaCOi, talc, asbestos, and alkyd-styrene varnish) did not affect the PHYSICOCHF2M. PROPERTIES or the ORGANOLEPTIC PROPERTIES of water, provided a proper ratio of surface area to vol. of water (1 m'coating to 2 mJ water).was maintained. 42476] Toxicity of polymer building materials employed in children's institutions. Gcl'tishcheva, E. A.; Khrustaleva. V. A.; Osokina, S. K. (USSR). Gtg. Vop. ProUuod. Primen. Polim, Mater. 1969, 208-16 (Russ). Mosk. Nauch.-Issled, Inst. Gig.: Moscow, USSR. The use of polylvmyl acetate) [9003-20-7) as an INTERIOR LATEX PAINT in children's institutions was prohibited due to excessive evolution of toxic substances into the air. The manuf. of furniture from K1BERBOARD based on urea-formaldehyde resin was not recommended either. PAPER LAMINATES were suitable for finishing wood furniture, however, all children's organizations in which polymers were used, should be ventilated at least twice a day for 1 hr. 42477k Folate-catalyzed elimination of formic acid during methanol poisoning. Rietbrock, N.; Herken. W.; Abshagcn, U. (Inst. Pharmakoi. Toxikol.. Univ. Wuerzburg, Wuerzburg, Ger.), Biochem. Pharmacol. 1971, 20(10), 2613-22 (Ger). coy* During methanol [67-56-1] <2g/kg) poisoning, a reciprocal correlation existed between formate (I) (C4-18-6) half-life and folic acid (II) [59-30-3] conen. in the PLASMA in man, dog, rabbit, and rat. Treatment of MeOH-poisoned dogs with amethoptvnn [59-05-2] (0.75mg/kg orally) caused a marked rise in toxic. I conen. in both plasma and urine. On the contrary, therapeutic doses (2.5mg/kg i.v.) of II produced an almost complete lack of I accumulation, presumably due to accelerated elimination of I. 42478m Primary irritation evaluation program study numbers 33-027-69/70 through 33-030-69/70 and 33-032-69/70 through 33-034-69/70. Rowe, Stephen E.; Steinberg. Marshall (Army Environ, llyg. Agency, Kdgewood Arsenal. MJ.). U.S. Clearinghouse Fed. Set. Tech Inform,. AO 1970, No. 867269, 8 pp. (Eng). Avail. NTIS- From Govt Rep. Announce. IU.S.) 1971, 71I1G). 68. Seven candidate INSECT REPELLENTS tENT-JIhsfi, ENT-16750. ;V7'-2U574-oGo, .Y7'-2'/82d-a, EST-32417, ENT-20593, and ENT-32844) were evaluated on rabbits for their potential to cause SKIN AND EYE IRRITAT10N The data obtained served ns a basis for making recommends1 ti-:.'- e ,v- n.iug ihi-lr pi'H-ntui u-e m. humans, l.'Dtin Primarv irritation evaluation program siudy. StuGv unmoors 33*(8)l-7(). 33-006-70 and 33-015-70 Jnnuarv-Manh, 1670. Spear, William J., Jr.; Steinberg. Mar-nail lArn-.v Environ. Hyg. Agency. Kdgewood Arsenal. Md.L L'.E. Clearinghouse Fed. &ci. Tech. Inform.. Al) 1970, No. STOj.'.O. S pp (Eng). Avail. NTIS. From Govt. Rep. Announce IU.S ) 1971, 71(16), 69. In a atudy of the potential of INSECT 7(e ? 2? 7." OLI 4988 .1 of )|f .1 V v 'lip J |.IT|S|V >1 I \ 1 I iwuitt**' ;nid of fi.k ten, "crvcd (by M. I lava ulnte (radioi)s of uhan K.; Sargent, ss.), Lipids 1971, id in (ha ability of ng and normal mac lodiliyilrosphingon.\ into ccratnidc; lingomyclm. ucleic add poly, vith Rout sarcoma I. (McArdlc Lab, W'is.). J. Virol. Ill tlie U77 strain iced no virus-like production of in- of the B77 virus ,o del. the relative s-infccted chicken tch less B77 virus i cells. RNasc.nt in high-speed -infected rat cells. - contained lesser yincrasc activity, nrrase activity in as not related to irus. The DNA high-speed pellet extent with H.\A with Ris'A from virus 40 antigens Tsuchiya, Y.; iiois llniv., Car`<0 (ling). The section of an esells with simian ly infected with ^Jailed to induce ^nciniccted with ^HFtetl cells was c rate of DNA J after infection mtly lower than h had not been xert significant `t against SV40 of neoplastic rivation. Lais(Dcp. Pathol.| I 09U), 57*04 incubated in a ` Ihe nutritional acid (L-lcucine, al and various conen. of LI multiplication cells, whereas eflcct on cell hr. The mean ue was reduced spending preii, resp.). In dturc mediuiti >\ytryptainine into prolcin- `he blood upon the earotidian i Univ. Babesa, Arc, Biol. l activity and ptl. model of vr conditions 'dficially by ixrkaleivia, inUdnior. 1 *-itli ni lit, ..iprtl vit, d ' ClHtlnierilU .train tii. on on the < I,, II Mil lilllll rlllll M.l ! I I il 1 . |l III 'Ml 1 Ml, I I' ll M' M I |||m Mil . Ml IK III II , Il ill > I ' .1 ' 111- |l | |l il I ll i ' I ! I, ! lit |i. I- i. 11111 mi t Ucgiiis with tin- ,|i,tiln aduiai,u, Mil III I I . -..Mil {mIImwi iI by n Mi.itki'il i IimIimi ir I, , iiilinvM'-t ni M M,l|i;i Mi I', W 11 M II dieappc.u s tiltu* .-.t i Miiipt, 0 ly 'ittiiit., t,i tin . ,,111 ll, vtll'.iliiinv which also ilmiiiii'.lu''. IIii- lidli.il lliii .hiihl , I 11v11< ri ,t|i i mm t ,\ll CI|lliV. lit ] II I HIM i;tll .I'llti.l lint1'. MU1, si IKIt II I i,,| I.mMc t llci ts on thy iu situ dog he.ii l, not on ihv carotid picssnre. Double vngotomy or ntrnpinizntiotl of the dog d........ mi itidnrc any olhcr effects. In lie Saunders 2370p Alterations of deoxyriboniicleoprotcin thermal stability induced by JytitplioryIt'-Kltrllcli ascites lunim tell uiterarticn. Alvarez, hi. R. (Dcp- IthiL. thiiv. South Hoi Ida. Tampa, l-'lo.). Exp. Cell Res. 1071, (19(1), 72-80 (ling). Bhrlnh ascite-s tutnor cells and normal lyinplioeytcs of the mouse were suspended in isotonic saline and allowed to settle on the surface of glass slides in equal densities. When the tumor cells and lymphocytes were attached to ilitleieut slide-., tlieiiual dciiaUttain u of the ilcoxy- rilKiinicIcoproteiii (DNP) was greater ni the liuimr nils. Wln-tt the two cell types were mixed and attached on mmmnn slides, the DNP thermal dcnaturation was greater in tin lyinplioeytes and melting occurretl at a higher temp, in both eell types. This relation held regardless of the relative proportions of cither cell type in a mixt. However, when the tumor cells constituted the majority cell type, the difference in DSP thermal stability was smaller, 237 lq Prostatic carcinoma of human origin transplanted in the golden hamster. Abdnlla, Ahmad M.; Oliver, John A, (Gavin Miller Mem, Cancer pound., R. Victoria llosp.. Mon treal, Qttc.). J. I'rol. 1971, 1011(4), 590*1 (ling). A trans plantable carcinoma was propagated in tbc hamster with evidence suggesting that it is a 3-ntcthylcholauthretic-trausformcd car cinoma. Roland S. I'iauniii 2372r Dynamics of RNA secretion into a culture medium by Ehrlich carcinoma cells in s short-lived culture. Ryazaitt- seva, I. N. (USSR). Aft. Aspir. Bob., Kazan. Cos, Lux:'., Estcstv. Aauit 1969, 129-32 (Russ), lidded by Belyaeva, M. I. Kazan. Cos. Univ.: Kazan, Ukr. USSR. The Ehrlich car cinoma cells harvested the Cth day after transplantation were centrifuged from the ascitic fluid, the damage was controlled by staining with neutral red, and tlte cells (2-6 X llF/ml) incubated for 3-3.5 lir at 37 in Hanks soln. with 1U' ( inactivated calf serum. The 2-tnl samples of the medium were taken at 30-min intervals. The cells retained their physiol, activity for 3-4 hr, the dead cells averaging 1.5 2'i. Using the JiP incorporation into RNA and a quant. RNA detn. the RNA content iu the cells and in the medium was studied. RNA secretion into the medium increased during the incubation from 21.1 pg/nil at the beginning to 32.9 at 2-5 hr. At the 3.5-hr interval, when the necrotic cells surpassed the active ones, the secretion rate de creased to 21.4 ag/nil. Ivo Kunstyr 2373s Zinc transport in ascites tumor cells. Guenther. Th.; Dorn, F. (Zeutralinst, Biochcm. Biophys., Frcic Univ., Berlin, Ger.). Z. Klin. Chcm. Klin. Hiochcm, 1971, 9(5), 438-42 (Gcr). Uptake and release of KZn by ascites tumor cells are independent of cell metabolism. SH reagents increased the rate of both uptake and release of "Zn. The rate of Zn transport was decreased by incubation at 0 and by changes in pH. Proteins Of the cell membrane arc probably involved iu Zn transport. Accumulation of Zn is attributed to complex formation within the cell. . ,.,.n V. N-Nekrassoff 2374t 0*tOf>akjwsy--sa ssf fat 'tongs; bowl to tiopl * (Regina Elena Inst. Cancer Rcsl, Rome, Italy). oghnttT.Tf?rr~1*71 `TH'*' 510-22 (Eng). dWarwlejs**(*s4a- MnotrOl--a** wit toBtfiW>wdL/ml., -4"hr/day, 8 days/week) jlfii jitoWsjo^iwoe yr ' Ibe cutaneous system 2375u Possible importance of the reading mechanism of DNA in carcinogenesis. Lowdin, P. O. (I)ep. Quantum Chcm., Uppsala Univ., Uppsala, Swcd,), I'hys.-C'hem. Mi'ih. Curi-iung.. Kriii-, Ini. Bvmp. 1968 frith. 19091, 293 7 (Knr.), Edited by Rcrgiiianii, ii. 17, Isr. Avail. S*i. limn.: Jerusalem, Israel. Carcinogenesis may involve damage to the priiiciii (nr other) Cover of the ''closed" part nf the DNA code. Reading the "closed" portion would produce normal proteins, but m the wrong cells, against which iiniimnol. defenses might not operate. Anal.oi the proteins of malignantcells is proposed. J. lUtnyau 2376v Rndioglobulin localization and immunospccificity in the transplanted human choriocarcinoma. Mizvjewski. Gerald J.; Quinones. Jose; llaron, Jennifer (Gen. Med. Res.. Veterans Arlni. Ifosp., Attn Arbor. Mich ). Ami-r. J. Phr!,t. Cynertil. 1971, 111,31. 413-1S fliti'l. IIhiii.iii , ,n : ic,, ai.,:..a traii-- i b'lts ill h.im-ter click pot. lie- ,:ini. t,. Undiu tm- nnine and iiMiiimmuiit r;ihl*,t iimiuniM-d'biilm f'. I ,,s shown by fa,iiMautoe,, imiatniodu,-rv-, vmc, and spent mmetric anal. 1 he iniravaseidar activity and in vivo hnniiiti,,spetiliyity oi tatlio .U'bulin pupils. was -mo,' ii by u-ini; untaeged whole rabbit sera us blocking agents. L magged rabbit anti-human eltorionie gonadotropin scrum could block radio-uptake in tumor and "'"V In 1 'mil.i .1, iinl.o'ia-d, to nil 111, mi mi i:, I, |,, t , miiIv niiii)ii iiiiIim:ii tivily levels, ltuili iiniiiiine and n, lil"< 1.1 in; '.el a I MU V have '.lid, IgC, reee|,tMr cite: to I' line, , ill Iiln; i.mI|mc,|m1,uIiii IgC, iqtlake. Po-sible lo. lor the I llliior's linle.eriliilll.lle IgO 11111.1 k e Ute ilisi 11,| S. M. y. 2377w Collagen synthesis in human keloid and hj scar. Cohen, 1, Kelnian: Kciscr, Harry K,; s Alhvrl (lf\p. J'lur. Bt.invli, Natl. Heart l.uitg Inst., : Mil.). .Surg. i'onnn 1971, 22. 483-9 (ling). Measiu proline hydinxylase aettvity (1) in skin correlates mil rate n( collagen synthesis. This study compares ] i hypertrophic sear, and normal skin of humans, h was assayed by incubating minces of skin for 30 min wo prepd. (Vf)-proline labeled protocollagen substrate in tin of excess cofactors. The results indicate that the r.p lageti production as measured by 1 is significantly i|, keloids anti hypertrophic sears and partly explains the . collagen deposition in these stales. Sidim 2378x Carnosine anserine synthetase of the liver atoma. Parsltin, A. N.; Lebedeva, S. B. (Naud. Inst. Onkol. im. Petrova, Leningrad. USSR). Dnl Nuuk SSSH 1971, 200(3), 73G-9 IBiochctn] (lUt- binsynlhcsis of carnosine and anserine in the liver of mice was compared to that with animals with liepat it was shown that the tumor formation did not affect activity toward carnosine synthesis in any meaning: The work was done with "C tracing of alanine and residues. G. M. Km-, 2379y Effect of lymphosarcoma on content of sulfhy disulfide groups in tumor-bearing animal organs. l)ad I.; Novikova, E. N. (USSR). Zdraiookhr. Belarusi No. 6, 47-50 (Russ). From Re}. Zh., Biol. Khim. 197t> No. 19F1200. Content of SH and -S-S-groups in 11. scrum decreased gradually in rats with Hiss lymph,, during tumor development; min. content of SH grou; liver corresponded to tltcir max. content in tumor tissu. tent of SFI-groups increased and -S-S-groups decrease,i tumor tissue growth. 2380s Stability of chromatographic patterns of ar transfer ribonucleic acid from individual mouse plasma, and variability among different Immunoglobulin A pi, plasmacytomas and normal organs. Mushinski, J. (Lab. Cell. Biol., Natl. Cancer Inst.. Bethcsda. Md. chemistry 1971, 10(21), 3917-24 (Ettg). The leucyl-, scr tyrosyl-tRNAs from IgA-produciitg plasmacytomas ami tissues were compared using reversed-phase chromat.i biol. stability of these chromatog. patterns was cstabli comparing the patterns of these aminoacyl-tRNAs from transplant generations of a single tumor line, which wn to be very' similar. Confirmation of the concept xb patterns reflect a stable population of tsoaccepting s| tRNA comes from the finding that the tRNAs from ferent tumor lines which originated in the sane primary have the same patterns for the three aminoacyl-tRNAs Four normal tissues examd. in this way showed almost n tion in the chroinatog. pattern of tyrosyl-tRNA, small th: in leueyl-tRNA, and somewhat greater differences i tRNA patterns. Four plasma cell tumors which seer immunoglobulins with antibody activity showed pati ferenecs among themselves which were much more striki the differences among the normal organs. Possible sm this variable degree of pattern variation arc discussed. 238It Histidine decarboxylase in the transplantable philic gastric carcinoid of Priomys natalensis. Hos,, Nakamura, W.; Snell. K. C.; Stewart, 11, L. (Lab. i Aichi Cancer Cent. Res. Inst., Nagoya. Japan), i' Pharmacol. 1971, 20(10). 2671-6 (Eng). A transpl argyrophilic gastric carcinoid of Praomys uahtlensis Cy appreciable activities o( specific histidine ikcarlto\\! ttrnnialii' cells, probably Instamitte-emitg. argyrnphil v. Uihutcd in the gastric mueosu. Speeitic histidine deealL (ree [nun aromatic L-amnto aeiii decarboxylase wa> ID-told by acid plus heat treatment and subsequent 1 N ppm.; it was not essentially different (rout that prep other mammalian sources. 238!u Autotadiogi iphic studies on cellular prolifer vivo of human gastric mucosa in normal anti pathohi. ditions, after arterial perfusion of tritiated thymidine inoto, Hajinie (Second Dcp. Pathol., Kyoto Prelect. I ni' Kyoto, Japan). Kyoto Furdsu Iho /hiijitii Zi.t" 80(7). 399-418 I Japan I. Isotonic glucose soln contet" `It was injected into an artery of gastric cancer inf' injection pressure sh.'.htly above tbc systolic pris-urv, tion of iiijectiun was usually about 39 mm iab.. (Ll) was almost equal at any site of the tumor, given for various types of carcinoma. There u f a 11:'' LI of gastric carcinoma and metastatic carenv- ' m nodes. Chronic gastritis was found m tioneai.e'r.,.;- around the tumor. ^" It. JitiliC OLI 4989 10// t.lli II.I Alr.ll.n ). V-.l /!), l'i/J / loading. I'nenmnmu, pastemrlln.i1., ami lima luinn,i i hnge were obsd, i>i animals 107797r Renin level in llie kidneys of experiment.d animals during chronic poisoning with a mixture of o.mcthyk.iYreiii1 and 1,3 butadiene, Nn ebieimil.nv, li. A. (USSR). A'un.lt. li., Omsk, Med. hist. loon, No. SS, 2t I 8 (Kn-.x). I In- amt. of renin (1) gi.mnles gtmln.dly x.mixbcil fumi "epilliilmd" ei lls m rats inhaling admissible eouens. of the title mist., Imt laler on 1 reappeared. A picture similar to protein dystrophy of the kid neys developed. 1). I*. Isaiah 107798s Posttoxic reparative regeneration of the liver of rats with intact adrenal glands and with corticosteroid deficiency. Yakobson, G. S.; Gromova, O. A.; Dobrovol'skayn, S. G.; Kondakova, A. E,; Nosova, I.. V.; Scregina, N. M.; Shorina, G. N, (Cell*. Sci. Res. Lab., Novosib. Med, Inst., Novosibirsk, USSR). Byult. Eksp. Biol. Med. 1971, 72(7), 95-<J (Russ). The livers of adrcnalectomixed rats with carbon tetrachloride poisoning did not show the reparative processes typical of the livers of intact rats after CCh imixouiiig. Instead, then- was a greater spread of dystrophy in the liver, a drop in acid RXasc, and no change in DN'A and RNA or in blood scrum il-globulins. 107799t Toxicological study of formamide and its N-methyl and N-ethyl derivatives. I'hatn Huu Chanh; Nguyen Uat Xuong; Azum-Gcladc, M. C. (Cent. Rcch. Toxicilcs, CNRS, Toulouse, I'r.). Thempie 1971, 2t>(3), 409 21 (Fr). The aettte toxicity of formamiilvs to rats and mice was in the increasing order: formamide, Af-iiiclhylfnrniaiiiidci A'.A'-dimethylformamidc, A'-ethylformnmule, anil A(,Ar-iliethylforniamidc. Mice were more susceptible than rats. The coinpds. induced testicular lesions. Repeated small doses of /V-cthylformaniide and N.N- dimethylformarnide stimulated the growth, whereas the other dcrivs. were growth inhibitory. All tiie derivs. given in repeated doses increased the blood calcium level but depressed the urinary excretion of Ca, and the blood levels of potassium and sodium. 107800m Toxicity of tissue culture media exposed to poly- (vinyl chloride) plastic. Dcllaan, Robert L. (Dcp. Embryol., Carnegie Inst. Washington, Baltimore, Md,). Nature (London), Nrui Biol. 1971, 231(20), 85-G (Eng). Blood scrum-contg. solos, perfused through poly (vinyl chloride) administration tubing, of tlie type used for blood transfusions, became highly toxic to cultured ciiick embryo heart cells. 107801a Effect of folic acid on deoxyribonucleases in the mouse kidney. Temple, K. (Ticracrztl. l-'ak., Univ. Mucuchen, Munich, Ger.). Z. Naturforsch. B 1971, 20(0), 589-04 (Get). C0>H I HOjCCWjCHjChnhCO -------------HHCH; w^ The cllect of i.v. admiiiistration of (10-180 mg folic acid (I) on the in vitro activity of DNase of the kidney and the DNA and piotcin content of kidney and thymus of 400 mire was investi gated. Abml-alt SI)'deerease of renal alkaline DNase (E.C. 3.1.4.5) (II) and a 180% increase of an arid DNase (E.C. 3.1.4.5) (HI) and of a II inhibitor (IV) were obsd. 2-4 days after injection of high I doses. The protein and DNA content of the thymus behaved similarly to the II activity of the kidney. The increase of III in the kidney was due to enzyme induction by I. The decrease of II was due to an enzyme loss out of damaged cells and to the induction of IV in the kidney. Preliminary studies on I-induccd damage of the kidnry suggest that IV plays a certain role in combining protein and DNA synthesis by inhibiting II. 107802p Morphohistochemical changes in white rat brain during acute poisoning with n-methylstyrene. Zakharchenko, V. I. (USSR). Naueh. Tr.. Omsk. Med. Inst. 1909, No. 8.8. 19C-201 (Russ), Different doses (2-3 ml) of a-utctliylslyrcnc (I) were given to 10 rats perorally in an acute exptl. to investigate1 its effect on hrain. In the following 1 2 days fl animals ilieil. Diffuse disorders of the neurons of the brain stem were eliarae- terislic. These were not ob.d, in the cortex and in the basal nuclei. There acre circulator}1 dividers causing liematoinas, edema in the brain material, and increased dystrophic changes of the neurons, csp. to anoxia-sensitive areas (cortex of the dominant hemispheres, diencephalic lield etc.). J. G. Fischer 107803q Specific treatment of acute methyl bromide poison ing. Mizyuknva, 1, G.; tlaklushev, G. N. (Vses. Nauclino- Issled. Inst. Gig. Toksikol, I'cstits. Pnlim. Plast. Mass, Kiev, USSR). Vrach. Delo 1971, (7), 12S-31 (Russ). Cysteine (I) nSCejC-mj-pcCjM I was an effective prophylactic and therapeutic agent against abs. lethal doses of mctlijl bromide in rats, mice, and rabbits when administered orally or s.c. 30 mm Ixfore or s.e. within 5 min after acute jioisoiiiiig. I restored the level of sulfhydryl groups and prevented changes in carboxyl and amino groups in the whole blood, sermn, and protein and nonproteiti fractions. I prevented the death, paralysis, paresis, and spasms which developed on the 3rd--Itb days after Meltr inhalation in untreated animals. IlftHthlr nisloInpYnl nnd histochcmicsl changes in m, , Kvjc.pr iliimrtillciirr tthlieit offfffcucc tI ro,ff lthite* eclhivriosniai!c* inh.'iflta_ ilfion hnini.ui. 1 | * methylstyrene, l.ambina, K. A. (USSR). Nuuth T,' Med. Inst. 1909. No, 88, 190 5 (Russ). Rais were ti,-.,,', . vnpois ol o-melliylslylelie ill COUCHS, o[ ll.lm.1', mid ll.(X).''I'lie inhalation lasted lor 4 iiinnllis at () hr/ilay. A xlioii . of the almvr (leatmeiit resulted in uiiimporiani ami p,,,', changes in liyer paiciichynia: fatty hepatic cells, lower glycogen in their cytoplasm, and redistribution of nh.-; protein, protein, and sulfhydryl groups. At 1 month tl... plinl. picture iiotmalizcil. New changes were obsd, follow,- 2nd month, which were similar to the changes of the inii,,1 riod. After 90 days the most significant changes were f,,, the liver. There was no difference in the results from i concns. of I except for the time of action. J. G. I,.,. 107805s Changes in the secretion of the epithelium ui v rat trachea and bronchi during the action of a-methylst- - vapors. Kuz'min, V, 1. (USSR). Naueh. Tr,, Omit. Inst. 1969, No. 88, 209-14 (Russ). Rats were treated uu pors of tt-mcthylstyrciic (I) gix-cn in a concn. of 0.b).` , The treatment lasted 6 hr/day 6 titnes/week for 4 mouths, ing the chronic intoxication a hypersecretory state devi l.,). the respiratory tract of the animals. There was a intr.i- exocc'.lular accumulation of neutral and acid inuco-suhst., such as sialiilasc-labile sialomucin. The resistm.ee of the r.. tury organs ugainsl damaging factors and influenza viru lowered, J. G. I-V,1 107B06t Pathomorphological and bistocheinical chan,/ respiration organs of white rats during the action of n-mr styrene vapors. Kuz'min, V, I. (USSR). Naueh. Tr., , Med. Inst. 1969, No. 88, 220-5 (Russ). Rats were treated a-inclhylstyrcnc (I) in max. allowable concn. (5.67 ingd.i treatment was 6 hr/day for 120 days. In the initial pin . epithelial portion of the respiratory tract was damaged. I,, Secretion of epithelial mucins and damage of perineal,,iu blood vessels (in connection with depolymn. of acid mui- . saccharides) were obsd. The max. level of cell reaction cm-, demonstrated at GO days, resulting in the accumulation mucopolysaccharides of hyaluronic acid and chondroitin- . type in the connective tissue of the lungs. At the end . expt..the new argyropbylic and collagen fibers dcntonsii u moderately significant picture of peribronchial and pern., sclerosis. These changes were accompanied by the dam > the general structure of pulmonary tissue: focal atclccta- emphysema. J. G. FF. 107807u Effect of a-methylstyrene on the tnorphcl picture of the kidneys of experimental animals. Sercbrcn O. A. (USSR). Naueh. Tr., Omsk. Med. Inst. 1969, s< 240-3 (Russ). The expts. were carried out for 120 days ,. i The first group was treated every day by vapors of n-u Styrene (I) in max. allowable concn. The second grou; treated at 50% of the altovc concn. The 3rd grou|) w Control. In the kidneys of exptl. animals changes were - depending on the doxe and intensity of exixisure. At 1 ginning of the expt. venous hy|wremia was obsd. Later i> dystrophy, plasmatic impregnation of vessels, and periv.. Sepn. were noted. In the last phase of the treatment de. tion of parietal cells of Shuinlyanskii capsules were obstl. J. G. Fi- 107808V Molecular composition of bones during , fluoride poisoning (studied) by an ir-spectroscopic im1 Abishev, Kh. A,; Sergazin, A. G.; Polctacv, E. V.; ' N. I. (Alma-At. Med. Inst., Alma-Ata, USSR). Zdr-: Kaz. 1971, 30(5), 28-30 (Russ). Changes in ir absorpn. tra of rabbit bones caused by chronic intoxication with ; studied. Rabbits were given 1.5-4.0 mg NaF per d.i> course of G or 12 months. The intoxication with NaF ! nl/oiil a decrease in the proportion of inorg. substanivlame. The absorption hand at G30 cm'1 decreased .md 48(1 cm11 increased under the influence of NaF treat nicni. D. D 107809w Histological investigations of the effect of oxides and ozone on some organs of laboratory anim.''llyczkowski, Stanislaw; Zawistowski, Staitislaiv; Wr/c- Krystyna (Akad. Med., Gdansk, Pol.). Gdansk. Bozpr. Il'vifc. 3 1909, No. 6. 101-5 (Pol). Chrome Dof a mixt. of N oxides with 0, in air caused changr'm stitial tisstic of the rat lungs. The rats extioxed to tin1 l-*r of NO3 had changes typical of bronchopneumonia ami trophy of the reticuloendothelial cells of the livir. I'1 doses of NO, were as follows: one exposure to 1 111 for 3 lir or to 300 mg/m1 for 30 min or 3 exposnr,' ' , each for 3 hr. M 11,1 107810q Carbon-14 dioxide elimination in experm1 toxica tion with carbon tetrachloride following d.l-as,-1 (4)-'*C administrabon under aspartate protection. Szantay. I.; Tamas, St.; Szabo, Piroska; Cotid. r Med. Clin., Cluj, Rom.). Bee. Bourn. Btofhft.. I"1 113-10 (Eng). "COj elimination was studied cm"., following DL-aspartic acid-4-1* C administration m * OLI 4990  ihlrv j,, ' h-mes (,| *Hfeill chronfi '"iiiinls "I- Insi lufljcd ii, "iiclrwi),, !<0 ,lavv nlar con. "f poison. Kalab carbonyl U- (Kiev, I'oliin. ben l ion ,,f I'hylactic reduced Rczdck ( brontou Univ. '1). S9-CJ blood of d the ext. ne-Et-0 , 'cas then bits given increased "as then fininistralevel uas ;'/g vcn .'ibashi change in - triphos- Nikulin, /liokkiiii. Htf. Zk., hyro.xinc by for 10 spiration h tissue, -.inistra dtstur- KW.:-b1dJsmaoymrpI-- rylation " Univ. I (ftal). pressure mv per. contg. per too arterial d. with active, th con' uses in not to Edward .1 pp. <Icr No. *iusUrd ui. Midi.). US and \i : pro* :s. ami ve* for were rpbol. rvated > from J'ldlv ilif'> the 'mqur }bur'Vu.; givdinieiv, 1'. I!.. I. Ill > li.iev, ; *li.. AUinnifi.v, M II \,nn liil'i-l*.' It'll, 111'.I . ll.tvmnlnl. Ollnp.. U.SMs ). ,1/f`if. /> . 1071, (.'0, 35 (Kirs), Cbnniii' iiilnxu ill inn with the in .ndtidi' lieK-ii him,'in 0 sit,* /k i; dnv ("i up In l-'D days) m - ,irnsed the Innnntinu ol bone i.ilhe. mid dil.ned the 111:111111'. **f .niiple Iioue (inclines in cxpls, with 11 iiiPInl* CM .'t.f, kg). Therapy with hcxachlotan niitidnte iiorir..ib/cd the healing prn- ,-ess only paitly. M, Uavn 96889u Biological features of the nemntnridc Nemngotl, .mil its hygonie cliaiattciisliis. Knkhmaiiilknv. N. N. (Mo.!;. Med. lust., Moscow, I'hSIt >. Mnl.Z.li. It!,. 1071, (5), 11 IK lltiiss). Chronic administration of Ncmagon (U-5-5.(J mg/ki;/- day for 8 mouths by mouth) to adult nrtle rats caused pathol. changes in the function of central nervous .system, kidneys, and suprarcnals, and in heinatopnicsis. Morphol, ihangcs were fnuittl in the kidneys, liver, and gonads. The min, toxic dose was 0.05 mg/kg,'day., The max. allowably emicn. tiropnscit is n.m tug/l. M, llava 96870a Toxicological characteristics of Sevin. Muminov, k. 1.; Eshkahylov, T. D.; Mukliitdinov, A. G. fSamark. Med. Inst., Samaikand, USSR). Med. Zh. Uzb. 1971, (5), 18-90 (Russ). Chronic administration of the insecticide Sevin (5 and SO mg/kg/day by mouth for C months) raused pathol. changes in rabbit liver, heart, kidney, lungs, and internal ears. Serum aldolase and alanine transaminase increased after the 1st 10 days according to the amt. of the dose. Doses of 50 ing/kg/day killed 7 rabbits of 18. and doses of 5 mg/kg/day killed 1 rabbit of 18. M. Hava 9689Ip Primary toxicological characteristics of Sumithion. Akhnicdov, 11. K.; Boiko, 1. II. (Otd. Pilau., Uzb. Nauchno- Issled. Inst. Sanit. Gig. 1'rofz.abol., USSR). Med. Zk. Uzb. 1971, (5), 34 (Russ). Toxicity of the insecticide Sumithion was studied in 30 male rats and 70 male mice. The oral LDa in rats was 837.5 mg/kg; in mice 70S mg 'kg. The behaviour changes during intoxication arc described and are similar to changes evoked by other organophosphates. M. Hava 96892q. Pathomorphological changes in rat organs after administration of threshold doses of monuron and its mixture with atrazine. Nczcfi, T. A. (Inst. Epidemiol. Gig., Ashkhabad, USSR). Zdravookhr. Tnrkm. 1971, 15(1), 8-11 (Russ). The herbicide monuron (40 mg/kg, by gavage) did not cause clin. symptoms of intoxication, but monuron did cause reversible mopphol. changes: damage to the erythrocytes, methemoglobin emia, hypoxemia and resulting changes in the cerebellum. In addn,, pathol. changes in the liver, lungs, myocardium, and kidneys occurred. Administration of a tnixt. of monuron with atrazine (35 and 25 mg/kg, resp.) resulted in less severe patho- niorpnol. effects. Maria Lesiak 96893r Unithiol accelerates mercury excretion from birds. Tishkov, A. I. (Vscs. Nauehno-Isslcd. Inst. Nczarazuykh Eolczu. Zhivotn., USSR). Vtlcrinariya (Mosroiu) 1971, 47(3), 89-00 (Russ). Unithiol (dimcrcaprol) (I) injections accelerated llg excretion from birds. After injection of 1. llg was initially coned, in the liver and kidney while the IJg content in other organs was reduced. With further administration of l Hg was completely eliminated within 45 days. V. Bezrick 96894s Toxicological characteristics of an anthracene- toluene-phenol-formaldehyde resin. Nagornyi, P. A. (Kri- vorozh. Inst. Gig. Tr. l'rofxabol., Krivoi Rog, USSR). Gig. Primers. Polim. Afater. Izdelii Nikh 1969, No. 1, 205-70 (Russ). The title resin has very low toxicity. Long-term oral administra tion may cause pathul. changes in the central nervous system, liver, and kidneys of nits and mice. V. lJczdek 96895t Skin-irritating and allergenic action of fabrics made from polyamide fibers, Ivanova, T. I'.: Stnisvk, N. K. (Uses. Inst. Gig. Tok.xikol. I'cslils., Polim. Plast. Mass, Kiev, USSR). Gig. Primett. I'ahm. Staler. Izilclh Nikli 1969. No. 1, 227-33 (Russ). Wattr exts. of the polyamide filx-rs Kapron and Anid cause sensitization and skin-irritating eflecls m guinea pies. V. Ilczdck 96896u Toxicity of chemical substances isolated from poly- (vinyl chloride) materials. Ruimporl, R. A.; Markova, / S. (lust, Ob.slich. Rommmiaru. Gig, im. Si-ina. Moscow. USSR), fog. I'limru, /'.i/:in. Mater. Irde.'ii A i/'A 19o0, No 1, li (Russ). Chronic sgin application of est*. from po!> 1 vinyl chloride) to guinea jugs ami rabbits caused significant leukocy tosis. V. Urzdi !; 96S97v Toxic and teratogenic effects of saturated and un- saturated fatty acids on house fly larvae. Qurai-ln, M. Sayecd fUcp, Emomol., North Dakota State Univ., pargo, N. Dak.), J. F.hI.'h'i-.!, 1071, lit,11;, 7S7 0/ (Engl. Said, and un-.Or(, fr;tv ai'.-N iiit.rnrvd wo'i tin- ,, ri'.-ori .3 : 1: U, ,* j dies ,..Uiu,-|i ,/,oi:i >;ir.i / and wvtc tone ..Ian a,.,....... 1 1 e larvae 01.2 gl,.. De*atd. fatty aeid>. a compute -.ru- .ii 1- tuixald, fatty acid- contg. S to 1J C ..toms m the chain and a foij-2-ilouble liotid, and fatty acids w 1111 a triple ljon.1 in po*i- tion 2 were 111.t'.lf(d. tror/r-2-Octenoic acid was the most toxic, causing 100", mortality at 0.'.'ml larvae, 96898w Differential interaction of aflatoxin B; with deoxy ribonucleic acids from different sources and with purines and oinii' 1111. Ir'.r.id. : h.ilmit, ). (\ i\..il, Nutt, ir 1 , Im.i,, tomir. Jsi-i. hid. lies,, Pietoii.i, S. Air.). Chtui.`lliol. lulenii. ./"in 1971, 371 82 (Engl. Atlnloxin ]13 (I) was capable 00 of weak binding In thermally denatured l)NA as well as with highly polymerized yeast and calf-thymus histone. The inter action of 1 with UNA was dependent on base sequence rather than on base cmnpn., and a mol. of the toxin was bound to approx. 18 mols. of calf thymus DNA-P. The purine bases and the pres ence of amino groups in the purine mols. probably played an important role in the binding of this toxin to DNA. 96899x Action of atmospheric aldchydie pollutants on the NAD-NADH system of the rat liver, lung, and brain. Ala* bert, Nicole; Godin, Jean; Boudcnc, Claude; Roussel, Andre (Cent. Rcch. Pollut. Atmos., Inst. Natl. Saute Rcch. Med., Lc Vcsinet, Pr.). C. Jt. Acad. Sci., Ser. D 1971, 272(20, 33G3-6 (Pr). Exposure of rats to the atmospheric pollutants acrolein, formaldehyde, and acetaldehyde in concns. of 90, 140, and 10,000 ciii'/m1, resp., for 3 hr, modified the NAD and NADU levels in various tissues. Acrolein depressed the NAD1 levels in the liver, lung, and encephalon ami increased the NADU levels in the liver and encephalon. HsCO depressed in the encephalon the NAD* level very markedly, and the NADH slightly, AcH increased the NAD+ levels and depressed the NADH levels in the liver and lung. 96900r Morphological changes in white rat testicles during the action of a-methylstyrene and 14-butadiene vapors on the animals. Morozov, G. 1. (USSR). Natick, Tr,, Omsk, Med. Inst. 1969, No. 88, 249-53 (Russ), a-Mcthylstyrcne (I) dis turbed permeability of veins in that blood proteins accumulated in their walls and the stroma of testicles. Spermatogenesis was inhibited and dystrophic and necrotic changes finally developed. There were, however, signs nf adaptation to I. Restoration of spermatogenesis after 00-90 day treatment with I took >24 days. The title mixt, showed the same effects as I alone. D. F. Kalab 96901s Histochemical study of nueleoproteins, amino acids, and functional groups of protein molecules during experimental poisoning by cracking gas. Lyutikova, T. M. (USSR). Nauck. Tr., Omsk. Med, Just. 1969, No. 88, 274-81 (Russ). Rats (200) inhaled cracking gas (0.01 and 0.003 mg,'l., expressed as HjS) 6 hr a day for up to 120 days, Histochem. changes in the central nervous system were due to disturbances of intracellular processes. A severe decrease of Sff groups was obsd. in neurons of the motor and thalamic regions of cerebral cortex. Redistribu tion of protein SH groups probably depended on cellular en zymes, tile activity of which is controlled by the presence of SH groups. Changes in carboxyl groups (mainly glutamine) indi cated that detoxication of Nilj was disturbed. D. F. Kalab 96902t Morphological changes in the internal sex organs of female white rats during the action of vapors of a-methyl- styrene alone and mixed with 1,3-butadiene on the animals. Morozov, G. I. (USSR). Nauch. Tr., Omsk, Med, Inst. 1969, No. 88, 254-GO (Russ). During the 1st month of poisoning fe male rats with the title tnixt., the no. of primordial and maturing follicles decrcasetl. Large nos. of corpus lutetim were preserved and their luteinizing cells contained numerous RNA granules and large particles of glycoproteins indirating that these cells were functioning anil active. The nos. of eosinophils in the mucous membrane of uterus anil pyromunphils in stroma increased some what. After 2-3 months, signs of adaptation to poisoning ap peared. D. F. Kalab 96903u Effect of the long-term action of small concentrations of n-mcthylstyrcne alone and in a mixture with 1,3-butadiene on the cholesterol level in the scrum of animals. Chukrcev, E. F. (USSR). Nnu, It. Tr., Omsk. Med. lust. I960. No. NS. 2C.1 -4 (Russ), roi-ouing with the title tnixt. or u-methylstyrene alone (or 1211 days increased the elmlestet'nl eoiitents in blood of S 1 tals, particularly cholesterol esters thorn 211.3 to (14.11 tml ). D. F. Ralah 96904v Accelerated elimination of methyl mercury from animals. Takahasht, Miioslu; llirayama, Kiuuko (Mod. Sch., Kumamoto Univ., Kumamoto, Japan), Nature I Landau) 1971, 232(5307), 201-2 (Eng). Continuous oral administration of reduced human hair powder decreased the level of residual lmthvl inerttiry m mice poisoned with methyl mercuric chloride, 111.;,, .tin . t il it un-lily 1 mercury 1 li i xctete*l into iute-tiia s v ehiniiiat*id by this proeeduri in the itec*. Reabsorptnm oi I ex creted into bile may be 1 of the reasons for the prolonged bioi. half-life of I in the animal and any material that has I binding ca pacity is resistant to digestion ami absnrptiott from the must.ne ntay lie useful for eliminating I from annuals. Synthetic resins with Sll groups may be effective for the same purpose. The procedure may be useful in cases of accidental ingestion of org. 7l' >'* xu c.. OLI 4991 isiuMi Chrinienl Air.Ii... T. Vol. //I, l'J/1 >E< 2UZ olliti fiiutino,. ruble ('('!* ciiIiimi util'll, 1* uilocit ation in- cieasi d Hit- a* I ivil y of i bn u'.c-b phospbal a' c. AH til I hr * In sults may help It* t t plain till dlllt n n< c, ami mnlal ii a". In I a i mi ceil ami t\Inin I1 pm -imini:, ])/. I \ 123241q Hisloclicmical study of the "adrcnoroi licnl lipid hyperplasia" induced in rats by aniline. Horvath, Eva: Ku- vacs, Kalman; Ycghiayan, E. (lust. Mwl. Exp. Sure., t'uiv. Montreal, Montreal, <>m .) ,lr/n lliilmhnit, 1971, 39(1), 1 TiI -- 01 (Eng). S.e. administialioii of ,'tl) in|-, aniline (I) to rats foi 7 NMj or 14 days caused adrenal enlargement, increased the amts, of sudauopliilic lipids and cholesterol, but decreased the activities of sueeinie dehydrogenase, lactic acid dehydrogenase, and steroul- 36-ol dehydrogenase. 1 probably interferes with corlicustcroido- gcncsis at the adrenal level. 1C.]X 123242r Gossypol: subcellul&r localization and stimulation of rat liver microsomal oxidases. Abou-Donia, Mohauted B.; Dieckert, Julius \V, (Dcp. Bioehcm. liiopliys., Texas A and M Univ,, College Station, Tex.) Toxirei. A[>)>!. Pharmacol. 1971, 18(3), 507-1G (Eng). In rats, although the level of gossypol (I) after oral administration was not exclusively segregated in any 1 liver cell fraction, most of it was found in the microsomal frac tion. I was distributed according to its lipid-sol. property rather than by virtue of its reaction with protein. In rats fed _.I, the liver microsomal enzyme which catalyzed the oxidative demcthylation of p-chlofo-A'-methylanilinc-HCl (II) increased in activity. A no effect dosage for the stimulation of demcthylation of II by dietary gossypol was 50 mg/kg. The I stimulation of rat liver microsomal oxidases seems to be due to an increase in enzyme synthesis since it did not alter the Km (G.7 X 10~M/) but increased the max. velocity of I demcthylation (33%). The ability of rat liver microsomal enzymes to dcalkylate some car bamate pesticides was increased by the oral administration of I. DCJN 123243$ Exploratory study of automobile driving perform ance under the influence of low levels of carboxyhemoglobin. Kay, A. M.; Rockwell, T. II. (Hep. Ind. ling., Ohio Slate liuiv., Columbus, Ohio). Ann. N.Y. Acad. Set. 1970, 174(Art. 1), 366-408 (Eng). Estd. automobile concns. of CO result in 8% of the nonsmokers having blood carboxyhemoglobin eonen. levels greater than 7% and 4% having greater than 14% car boxyhemoglobin, assuming that they were exposed for two hr or more. Smokers would have carboxyhemoglobin levels up to 15% higher than these depending on their smoking habits. Several of the effects of carboxyhemoglobin were definitely detrimental to driving performance. Harry W. Gordon 123244t Effect of carbon monoxide on human performance. Mikulka, Peter; O'Donnell, Robert; Heinig, Patrick; Theo dore, James (Old Dominion Univ,, Norfolk, Va.). '.Inn. A'.Y. Acad. Set. 1970, 174(Art. 1). 409-20 (Eng). A study was under taken to dct. the effects of CO on relatively simple applied per formance tasks. Carboxyhemoglobin (COHb) levels reflected a direct relation with the ambient CO exposure levels. The in dividual performance curves revealed no consistent differences as a function of low levels of CO exposure. Harry W. Gordon 123245U Human performance of a psychomotor test as a function of exposure to carbon monoxide. Hanks, Thrift G. (Syst. Corp., Newport Reach, Calif.). .Inn. AM', .lead. Sci. 1970, 174(Art. 1), 421-4 (ling). No effect on performance of the crit. tracking task of Jcx (1966) attributable to CO exposure was found. An empirical relation was obsd. between pulmonary CO and blood carboxyhemoglobin values. Harry \Y. Gordon 123245V Chemical poisoning, lloogrndoorn, D. (Sliclit. Med. Reg., Utrecht, Nelli.). A'erf. Ttjdsehr. Grnrrit. 1970, 114(39), 1644-5 (Xetli). Statistics were gathered in the Nether lands on poisoning by chem. contpds. other than cotnpds. for medical use. Poisoning by CO was the most frequent type dur ing the period 1967-68. The largest no. of poisonings were en countered In the 1-4 act group, Thcv were pnttcipnilc due to petr..!i i.i.i piodm t- nni .n.h.-Lr.n' - 1 v < i N. G. i.Yreiui'v , 123247w Disintegration products and smoke genciation from i* fire action on plastics. 1. RuiuN-rg. Eckhani iSlaat). Malc- rialpniefungsauu. Nurdrheini-Westfalen, Dortmund-Aplcrbeck, Ccr.) VPl ( Ver. Pent. /(.) Z. 1971, 113(1), 20-4 (Ger). The toxicity and irritating ciTccts of smoke and products of the thermal degradation of plastics on rats were studied. The fiossiblc detn. oi relatixe loxieity of these combustion gases is also discussed. The toxic efforts of caseous pyrolysis products of polyolefins, polyfvinyl chloride; 11*\ Cj, polystyrene, polyaery. loiiil ile, polviuelliai-ryhdes, and oilier `.viithelie jmlyiners were si iidu d mi aniiii:i)s and him mils. At 2 3011% i hca- polymci s gave oil i: aim h wi Ie lev. In til lo Mis I liau IIiiim* of wood or I libber. I'Vl' cnmhtisl inn gases weir the most loxir of the synthetic plastie decotilpu. products testeil. BEJG 123248X Toxicity of bilirubin, lfcek, Kurt (Gastroenicrol. Abt., Med. Umversitactskliii., Frcihtirg/Br., Ger.). Pent. Z. Verdau. Slnffirrehtrlir. 1970, 30(1-2), 47-51 (Ger). The i.v. I, 1),* of biliiubin il) in rals is -.-Kid nu;/l;g. The animals In come ntuetic and die in tonic ronvulsioiis, liirieuscd scntiti trausaininase values, necrosis of liver and myocardium, severe renal tubular damage, and marked hemolysis with hcmoglobi- ncmia and hemoglobinuria were obsd. By inhibiting respiration and decoupling of oxidative phosphorylation, I blocks its own detoxication, which depends on normal oxidn. and intact oxida tive phosphorylation. The toxicity of I is higher in adrenal- cctottuzcd animals, which is partly due to glycogen depletion in the liver. This increase of toxicity is partly prevented by pre- treatment with synthetic glucocorticoids. Kurt H. Ztngraf 123249y Lead poisoning in cattle: brain lesions tnd hema tologic changes. Christian, R. G.; Tryphonas, L. (West. Coll. Vet. Med., Univ. Saskatchewan, Saskatoon, Sask.). A liter. J. Vet. Res. 1971,_ 32(2). 203-16 (Bug). In cattle witli Bli poisoning, diagnosed initially by din. and toxicol. observa tions, gross brain lesions consisting of ccrcbrocorlical softening, yellowish discoloration, and cavitation, were obsd. only in those with prolonged din. illness (>9 days), being most severe in the occipital lobes, but the tips of most cerebral gyri were aflected. In acute Pb poisoning, microscopic lesions varied from diffuse capillary activation to scattered focal areas of status spongiosis and necrosis of the cerebral cortex. In subacute and chronic poisoning, the microscopic lesions were located at the gyral tips and ranged from different degrees of status spongiosis, astrocytic swelling, and nerve cell degeneration to severe cavitation and vascular proliferation. Expll. induced Pb poisoning in 3 2-year old cattle produced acute, subacute, and chronic syndromes with clin. and pathol. features similar to those obsd. in naturally occurring Pb poisoning. David B. Sabine 123250s Intraerythrocytic 2,3-diphosphoglycerate and carbon monoxide exposure. Astrup, Poul (Dep. Clin. Chem., Rig_s- hosp., Copenhagen, Den.). Ann. N.Y. Acad. Sci. 1970, 174 (Art. I), 252-4 (Eng). 2,3-Diphosphoglyccrate concns. were measured in the blood after 24 hr exposure of normal individuals to CO, leading to approx. 20% carboxyhemoglobin. The results indicated an 8% fall ill 2,3-diphosphoglycerate, resulting in a higher affinity of Hh for 0 and a displacement of the oxyhemo globin dissocn. curve to the left. The same thing occurred w hen the percentage of reduced Hb was diminished by exposing pa tients to O inhalations or high atm. pressure (2 atm). Harry W. Gordon 1232511 Effects of elevated carboxyhemoglobin on gas ex change in the lung. Brody, Jerome S.; Coburn, Ronald F. (Sch. Med., Univ. Pennsylvania, Philadelphia, Pa.). Ann. N.Y. Acad. Sci. 1970, 174(Art. 1), 255-G0 (Eng). Small amts, of CO directly interfere with alveolar gas exchange. The tissue hypoxia produced by CO inhalation may be accentuated by rather marked degrees of arterial hypoxemia in patients with heart or lung disease. The arterial hypoxemia in these instances results from the CO-induced changes in the shape of the oxyhemo globin dissocn. curve. Harry W. Gordon 123252u State of the biliary tract of pilots and technicians working with chemical poisons. Kaskevich, L. M. (Klin. Otd., Yses. Nauclino-lssled. Inst. Gig. Toksikol. Pcstits., Polim. l'last. Mass, Kiev, USSR). Vrach. Delo 1971, (1), 133-6 (Russ). A group of 102 pilots and 30 air technicians working with chcm. poisons of the chlor- and phosphoorg. group was compared with a group of 104 pilots and 11 air technicians not exposed to the poisons with respect to their biliary functions. A higher frequency of biliary tract diseases was found in the ex posed group and often chronic cholccystoatigiocholitis had a latent course. Duodenal probing is recommended to ensure early diagnosis, and prophylactic hygiene is suggested. M. Hava 123253V Cannabis: study of the fractional extracts of the cannabis plant, smoke of cannabis cigarets, and residues in the urine of cannabis cigarct smokers. Kepetto, M. J.; Mcndcn- dez, M. (Inst. Natl. Toxicol., Seville, Spain). J. Eur. Toxicol. 1970, 3ui), 392-0 (Fr). Thin-layer chromaloc.. uv spectro photometry, and gas chromaton. of cannabis (hemp) plant c\ts., cannabis smoke and pipe residues, and urine of camiahi- smoker- was canicd out. The detection of cannabis component' pos'iblc in all of tlie'C sources. Dctiction in unne was larrud out by gas chromaton. using an SE-30 column on Chromo-orb after extn. with hexane and washing the ext. with NaCl solo. Kurt H. Zingraf 12J254W Effects of essential phospholipids (EPL) on thelipid contents of the serum and liver in white rats after a single dose of ethyl alcohol. Samochnwiec, Leonidas: Wojt.it hi. Jet') (Dcp. Pharmacol.. I'oiueraman Med. Acad., Szczemi, I ol. J. Med. USasel) 1970, 1(5), JU9-303 (EiigJ. The imrea-ct. amts. OLI 4992 wr - M / uyH iiiitf/ . at jyy, w)* li4 v.Uh ;iL\ in thru 1>1ihhJ, wrrr ;uin* j / 1 ,tOI I, ami Vho oiiiti ills m hlnotl, lr.itn, lu >(>*, am) 11vt-i , /. ni.iiol f>r i*;i ii itHliVhJu.il. rcsp. jHt \t will' I *(i.\ I tu t and 1,1; Il.M, it.til, 1,17, and 1*1, l.*l 1--\ 1 rrsp. 1'his indU'.ilr-, uneven of J-lOM in tin* linmnn l>idy. )). J*. Kal;d> Toxicity and reproduction studies of ecl'azolin in , .:-iiioorjVy nHinimm.nufs*. W" utan...a..f.iv- ,> \o--bu-o';I -/wa.n...a..i.u--i, Koki; ' ;,,.hi>uki /(Ri?ei.es. TLanhb.._, PFunjiiisMawwaa PPharttmn.. Co., LLttdd., OOssaakka:)! ,., Sippon Kogaku Kyolioiututai Zasski 1070, J8(.V ` "U.,'.(JIa--p.a,nu)v- \N'aa ccfnzoliii (I) with a mouse i.p Lll o{ NrN I NCH, C0NH- e t . t hr,, bad no teratogenic effects in cxptl. animals, but cx- , >,il lower renal toxicity in rabbits than did cophaloridinc. 1 ,'*i tug/kg), when gtven s.c. for 3 iiumlhb to dogs, caused ..tthage at the site of injection, which was accompanied by , loss of albumin, and by hypererythropoicsis in the , -tn and bone marrow. When given i.v. for 1 month, I was .,,, ;,l of such toxic effects. FK JY TtsSii Toxicity of trimcthylene glycol for the chick. Creek, < . ...ird D. (Dtp. Poultry tjei., Uuiv. Maryland, College Park, !.:.). Poultry Set. 1970, 49(0), 1086-7 (ling). Chicks given HOCHjCHjCWjOH J , vet rontg. 10% trimethyleuc glycol (I) showed extremely poor , mtti, hut no other abnormalities were obsd. BQ JN :H34a Possible mechanism of liver necrosis caused by aro- ritic organic compounds. Drodic, Bernard lb; Reid, Watson t> , Cho, Arthur K.; Sipes, Glenn; Krishna, Gopal; Gillette, ;jiar# K. (Natl. Heart Lung Inst., Natl, Inst. Health, Bethesda, IM.). /'roc. Nat. Acad. Set. U.S. 1971, 68(1), 160-4 (Eng). toxiiuent of rats with plicnobarbital (1) (80 mg/kg i.p.), which it.iiiulates the activity of the drug-metabolizing enzymes in the 'nr, |Hitcntiatcs hepatic necrosis elicited by bromoliciizctic attd <`rr halogcnated aromatic compels, such as 1,2-dibromobcii- I' .c, iodobcnicnc, and 0-chlnronaphthalcnc, Radioautugraphie I'ytH-s indicate that "C labeled brumobctizcnc (0.13 ml/30 g, t p i was covalently bound at the sites of necrosis, inferring that t:.e hepatotoxic effeets of the halogcnated aromatic hydrocarbons err mediated by chcin. active metabolites fonueil in bcpatocytes. c1 Inmhenzcnc, 1,3 diclilorubcurciie, and o-chlornnuphlhnlcuc Me eonverted by I-treated liver microsomes in vitro to active .termediates which formed covalent complexes with "S-labclcd i! i!Iiioric. FGJN 74453b Effects of hyperbaric oxygenation on metabolism. Vll. Succinate protection against oxygen toxicity in large ani- feils. Currie, William D.; Kramer, Richard S ; Sanders, tirmi p (Dep. Radiol., Duke Univ, Med. Cent., Durham, b C). 1`toc. Sec. Exp. Biol. Med. 1971, 130(2), 030-1 (Eng). * succinate (8 mM/kg/hr for SO min prior to and during cx- i**urt to 100% 0 at a pressure of 40 psig) protected dogs against t'pcrbaric oxygen-induced convulsions. The relatively large ru? doses were satisfactorily tolerated by the large animals in- ;*atmg that Na succinate may be useful as a protective agent humans undergoing hyperbaric O treatment. 11SJN ''<Sbc Hematological variations in rabbit* submitted to |-utute intoxication with sodium nitrite. Fratoni, Alma; <lnl' C. A.; Miucrio, C. F.; Violunlc, A. (1st Na/. Nutr., J..1'* Roma, Rofoe, Italy). Quad. ,Smh>n lhttt'n. (7in. l.nb. t * 9, 0(2), .70,0 3(1 (itall. NaNth (0 3H >ig, kg) udtiiimstr.ii uni , tilibils i.p, f(i( p) days caused a sicmltc.mt di, lease m clvth- ''tc-and an im rcase in ntctticumclolnii. A Inch dceirc of `l;,!t "is olisd. in all rabbits except for those tteated with the .; V' dose. No significant variation was faund in the no. of or in the osmotic resistance of the erythrocytes, and 1 c hilirubmcmic rate A slight decrease in Hb was also ob- ,,Yxa Carlo Bauer . Enzymic variations of erythrocytes in rabbits sub- *' to subacute intoxication by sodium nitrite. Oi Fclnc, to. Aihia, "i er, ani, (.; ','M . , A . 1 : Nio-., .. ` *'on:a, Rome, Italy;. Quml. .\itr.o lh.;;n. Kim, Liib. , ,' - h -ldl-u (Itall. `i'he iiclixities ,,f duiereni cu/ymes V1 Vlt` crythriieytc* of rabbits made aiuime by daily ir ' ^ N'n-v''Oi injections at doses of .1 ami lb mg kg body t. , ,fir "*s * clear decrease in pyruvate kinase ami lactate de- . (r ' at hotli doses. Glueosc-G phosphate dehydrogenase 1 "'g/kit and ilccreased with S mg'kg, this ap- ^ 1* /"^`nrilancc was attributed to the more St virc anemia at "slier dose. An increase was also noted in aldolase and V'*l /A, )WJ frL tr oi*.finiii.Isis, The decrease of pyruvatt kinase rx|ilainrd I lit imosec in incthcoiogtohiti via a dm tease in NA 1 t-dependent on iltctimglohin tcdiictascs (diapliofaecsj. Carlo Hauer 7-11 She Iai7ymic aclivitie.c ill blood setum of rabbits treated with sodium llittile. 111 bclicc, A,: hialonl, Alma; Galanlc, A.; Violaiitc, A. (1st. Na/.. Nutt,, llmv. Roma, Rome, Italy), (hnnf. ,Vituvii /Jiogii. Clm. I.nb. I9it), 0(2), 340 A (ltal). Si'rum enzyme leech were detd. in rabbits treated with NaNOj. An increase was noted in pyruvate kinase, lactate dehydrogenase, alk. phosphatase, and transaminases for 10 days. GIucose-G- phosphate dehydrogenase, aldolase, and transaminases after 10 days decreased. Lesions in some tissues were related to the above variations. Carlo Bauer 744591 Adrenal cortex dysfunction during subacute intoxi cation by sodium nitrite in rabbits Violaute, A ; l'ratoni, Alma; Cianetti, A. (1st. Naz. Nutr , Univ, Roma, Rome, Italy). Quad. Srlaro Diapn. Clin. Lab. 1970, 6(2), 340-50 (ltal). Considering the subacute toxic effects obsd, in rabbits treated with NaNOt, a serious suprarenal insufficiency was as sumed as the main reason of their death. The degree of adrenal cortex dysfunction was investigated through the levels of uri nary 17-kcto steroids and 17 ketogenic steroids; a sharp decrease in these steroids was obsd. G. De Stefanis 744<50z Lipid composition of RBC (red-blood-cell1 ghosts, liver mitochondria, ana microsomes of ethanol-fed rats. French, Samuel W.; Ihrig, Thomas J.; Morin, Robert J. (Sch. Med., Univ. California, Torrance, Calif.). Quart. J. Stud. Ale., /'art A 1970, 31(4), 801-9 (Eng). Lipids in liver mitochondria and microsomes after 13 weeks and in'RBC ghosts after 25 weeks re mained tincffcctcd in rats fed 30% KtOIf with an adequate diet. Mitochondrial phospholipid was reduced after 22 weeks. EtOH ingestion for 14 weeks increased some mitochondrial fatty acids and decreased others, but microsomal fatty acids were un changed. Harry W. Gordon 74461a Effects of ethanol on membrane lipids. Incorpora tion of palmit*te-l-uC into microsomal and mitochondrial lipids in mouse liver. Ferrell, William J.; Miceli, Joseph N. (Bio- cltcm. Div., Univ. Detroit, Detroit, Mich.), Quart. J. Stud. AL., Part A 1970, 31(4). 810-15 (Eng). Incorporation of pal- mitatc-f-UC into total lipids ol mouse-liver microsomes and mito chondria was reduced in vivo when mice were fed increasing concns. of EtOll; An inercased enzymatic hydrolysis of phos pholipids or a decreased synthesis is suggested. lfarry W. Gordon 74462b Comparative study of biochemical and morphological lesions of the liver of rats treated with tetrachloromethane and bromotrichloromethane. Calligaro, A.; Congiu, L.; Vannini, V. (1st. I'atol. Gen., Uuiv. Cagliari, Cagliari, Italy). Rats. Med. Sarda 1970, 73(4), 305-77 (Uai). The toxicitics of Br- CljC and CC1, were studied., BrCliC was more toxic then CCh. Felix Saunders 74463c Effect of poly (vinyl chloride) (PVC) dust on the re spiratory system of the rat. I'ojkiw, Jerzy (Akad. Med., Bialy- stok, Fob). Race. Akad. Med. Bialymstoku 1969, (Suppl. 24), 5-48 (Pol). Wistar rats (00) were placed for 1 hr a day in a PVC atm, comg. 92% particles of diam. <5 i The time of treatment varied in different groups from 1 to 12 months, after which sections of lungs were examd. PVC dust proved to be biol. active with mech. and toxic effect on the respiratory sys tem. Irena Kloczko 74464d Proof of poisoning with betloid and betlasponum (bellataminolum) during chemico-toxicological analysis. Lozo- vaya G. F. (Mosk. Med. Inst. im. Sechenova, Moscow, USSR). Sud. Med. Ekspertiza 1970, 13(4), 31-6 (Russ). Neotial, pheno* barbital, atropine, ergotoxine, and ergotamine were detd. in Bciloid and Bcllaspon tablets using thin layer chromatog. with CllCli-IitOlI-25% NILOII (20:5:1). The tablets dissolved in HjO or liver tissue to which the tablets were added were extd. with Cl 1 Cl] at pH 2.0. The aq. layer was made atk. to pH 10 11 and extd, with CllCh. Barbiturates were detected by the rcucli'ii! with dipjiiiiyliurlia/nnc unit llgSO, nr by micro- ery'dii. ic.iciimi with K1 in ihe ehuite. Alkaloids were detected 10 uv liglil, b\ *.|ti,1 v 1111: with laiioil still 1,, mid by nilte! elassie.d teni'.ents. The I1.11 Inlutalcs wen- alsn detd. in oigmis o( lablids given orally Bellonl or ltellaspon tablets with the barbiturate content in the range 500-1200 mg. The sensitivity of the method is 0.5 mg Xconat, 1 mg phcnobarbital. 0.3 mg ergot alka loids, and 0,2 mg atropine. Peter Skrabanck 74465c Phenobarbital and dexamethatone inhibition of the adrenocortical response of rats to toxic chemicals and other stresses. Szot R. J.; Murphy, Sheldon Douglas (Dep. l'hys- mi., I.irxarii Sell. Public Health, Bn-ir.n. Mas- 1. Tumid. Al'{d. pkiirmurol. 1970, 17i3), 701-73 (Eug). Plasma ami U, COCSfOH adrenal corticosterone (I) levels in male rats increased 2-1-fold OLI 4993 J4--Toxico/o/!/ Vol. 73. 1070 // 85994 , ,,n. niid in rarilinc, mull, ami ImR morplml. Tin: ."nil'll max. prriui'>''iliU' t'uiu'n. was (L3 up' id SL m1 if ' . ", Shi',, Joint Motvi',Si nit ,i'i' Influence f tit'lntium compounds on Hit i;cm.r.it'vc 1 Tsvetkova, k. 1'. (Mud. last. mi. Svili.i'i'ov.i, Mas. ' "sSiO- G'- Tr- 1'rof. Zatial. 1970, H(3>, 31-3 'Russ). , produced by various Cd eotnpds. on the ^iterative i n( ldC females working with alkali storage batteries and , i^ciitMOiitp. Cil ami 7,ii was slmlied. The women ware j m th.e efleet of Cd compds. in L'nnens. of 0.03 3n me, in'. ' nciis. do not affect the imnstrnal eyile, the course of , ,a, and term of delivery. However, the wl. of children ` i \iicn: females differed significantly from that of neonates a>posed females. K.vpts. on rats divulged the functional ,'! CilSOi on the cstrons cycle in females. The wt. of prt-- I'iaaks exposed to the action of CdSOi and the wl. of new|. :iu were significantly below that in control animals. The dewborn rats born to c\|-used female rats emilained 2.5 . n rimch Cd as those of the control animals. Within 3 ...after delivery 7c/r of control animals and 2'G(T of treated ,i. After 7 months' exposure to Cd the svts. of the preg- *ji> and control animals were not different. G. Muacevjc , ,;b Action of the polycyclic aromatic hydrocarbon 3,4oir-pvrene on isolated mitochondria of normal and tumor cells. , .'.-.ikiiva, N- A-; Pctrikcvicli, S. II. (Inst. Client. Natur. -ds.. Moscow, USSR). Akad. Hank SSSR, Scr. Biol. >' it, G1S-20 fRuss). Respiration of rat liver mitochondria , .uccinate was markedly inhibited by 3,4-bonsopyrcne when . . atnl (or 15 mill at 20 in the dark, and even more so when , .sited by long-wave uv light. Only a slight effect of 3,4. ; yvrcnc.was obsd. under similar conditions with mitorliun- . !iir. Jensen sarcoma, presumably due to disturbances in the > .'tunic system. Petr Skrabanek s'.'.Me Selenium, llognc, Douglas E. (Dcp. of Anim. Sci., i oil Cniv,, Ithaca, N.V.). J. Dairy Sci. 1070, 53(S), 1135-7 11. Se toxicity and deficiency in animals is reviewed with 27 BCJN i`.5hl Accumulation of manganese in rats during experi- isal manganese intoxication. Uoyadzhicv, V.; Khalachcva, l'nirv, I. (Hop. Varna, Varna, Bulg.). J. Ear. Toxicol. 2(4), 212-15 (Fr). The distribution of Mn in various ' ol rats given 100 mg Mn,H- (soln. of MnCI:) 'kg orally, - -i uthcr day for 00 days, was exanul. In control animals, the i >>i ronen. of Mn was found in the adrenals; brain, liver, )*. blood, and parietal bone followed in this order, lixptl. " .'milling increased thcconcu. in ait tissues, but it was highest " -vl and brain and lowest in liver. A correlation existed -* the accumulation of Mn and the duration of poisoning, Kurt 11. Zingraf '-s5e Effect of alpha naphthyl isothiocyanate on the liver of * and calves. Gopinath, C.; Ford, E. J, H. (Dcp. Ycl. : Stud., Univ, Liveriiool, Livcrixiol, Engl.). J Pathol. ' 5. Itt0{4), 209-80 (Eng). a-Xaphthyl isothiotyanatc . ! . *110' ord00 mg/kg, intragastrieoliy) increased both ' ' "use ATPasc activity around the canaliculi and the sinns- * *!i- phosphatase activity, and decreased glutamate dchy"jse, succinic tetrazolium reductase, and esterase activity l am] sheep livers. In the scrum, sorbitol dehydrogenase, J'c dehydrogenase, and arginasc activity 'increased, roncn- increased, and Bromsulphthalcin clearance 'iwil following AXIT administration. Hepatic peripurtal , ` .""d swilling, vaciuilation. and loss of paniculate staining. , 1 -ii. In the aliovc cliaiiecs, chronic admimstraltoii of AN1T . ` mg'ke''day) ilccrcavil the iilhiimiti-io eluliiiliii ratio ' Plasma am) caused intravascular ml cell breakdown, D/.JX Role of gastrointestinal absorption of kerosene in prn- l pneumonitis in dogs. Wolfe, Urine M.. llmilvnr. , * ' ^tields, J, H. (Si'll, of Med., St. Loins ruiv.. Si. - 4-" / Pvt'-M- 1970, fGfti), 8d7-73 dim;!, Alter , was injected directly into the stomachs of 7 pups, none - '.^nunals had any radio], evidence of pneumonitis, while . . .'r111' wnf tke 7 had histol. suggestions of edema. One had i "lorrhage. DCJX holer simulator sunscreen evaluations in guinea pigs. j 1: M irif'o' I'i*, ho I i. i 1.: ! in* ' 11. ........Mot .irrt M 'Nmth Klin.- ',.o i . i.. , Ami.), /, .So,, (,u . f "1:rn,' tu70. 2!-" i i7 12 1 d sim^i rei n prepns. eoiug, -iieli a< i:w in 'icoil in -as - A -lliitletllyhitllilinbcnznat*'. liuniniiivtillil I '.tlieyhile, ^ o:iobtiiZ0,c acid, were evaluated on viiinta pigs with ^"tiicd erythema both with and without wj-!nng afltr ", `I'J'j the noinvaslii'd site, most of the sun vreeiis i" irradn. ranging from 1 mm. erythcmal dose 9 MUD's. When suitsericii sitts were rmsed with soainyl.p.,V.A'-d;inclhyianiinulM o/uati in To' f ^ ' or iiyilro.it'- '-o'... - idt emelln tit. and Tm'tiithc'iMir 859Mi''Pafholiisy of vinyl chloride. Viola, 1*. Luigi (1st. / HetnL <Ven,, littiv. I*cntgia, Penntia, Italy), tied. Lav. 1970, 171 HMKne). Tw.,,1 y-fivu nus filler Ik'Im/: c\pr>srf] to viipiif s i.{ vinyl i hi*nnil1 ('.'{ihddfl ppiit^ 1 )i(/<l;ty a \\cik for 1 l`j monih' wiri' s.icjifn ri| ui lots at ^O-cIny mtrrvals. Afltr 1<) months some animals showed a di^rt-asc in wt. and aggressiveness to outside stimuli and disturbed cquil. 'ihirtcrn animals died from eanuorespiratoty tomplientions. Two animals died from hvinaiopt ntonemn. Mont -frtke imhnair Bboweil puthol. de* of itn* 4<rm.TiTT, k>dneyjrf thyroid. Si\ rats slnt`U`i| iti-topntImL ,`dt<rations of the skeleton. Degeneration of tlu st,> Ik (lift and eoiimrtive tissue was similar to that observed in human aeroostcolysis of the hamK. * J,. D. l*a);notto SSQSOj Pathomorphological changes in the lungs during experiments involving boron carbide and corundum dust. Urunditein, I. P,; Danilova, R. I. (Uzb. Nauch.-lssled. Inst. Saint-. Gic. Profxaliol.. V5SR). Mtd.Zh. Vzb. I960, (12), 40-2 (ku^ b Malt* rats fl .5 month old) were given boron carbide and corundum dust ini rutradically in a dose of 50 mn/ml of physiol, saline. The dust of various dispersions contained about 0(1 r/v AljOj. The animals were killed after 3, 0, 9, and 12 mouths. Intoxication with dust resulted in inflammatory processes with peribronchial and perivascular sclerosis. Some animals had catarrhal pneumonia. The permeability of the arterial wall increased and dystrophy of connective tissue, caused by destruc tion of the procollauen complex, caused reticular pneumosclerosis. M. Slavjkova 65990c Embryotoxic actions of trypan blue in mice in relation to the time of administration. Schluctcr, G. (Inst. Toxikol., Parbcnfabrikcn Bayer A.-G., Wuppcrtal-Elbcrfeld, Gcr.). Naunyii`S(hmiedebcr$ Arch. Pharmakol. 1970, 207(1), 20-30 (Gcr). Mice received 1 s.c, injection of trypan blue (100 mg/kg) at days (J-I4 of pregnancy, injection at day 8 caused highest percentages of lesorplions or malformations (notably exenccphaly). Injection at days S to 14 cause growth retardation. J.Dufrcnoy 6599ld Production of atherosclerosis in lathyritic aortas of rats. Hosoda, Vasulnro; Suzuki, Minoru (Dcp. of Pathol., Baylor Coll, of Med., Houston, Tex.), Pathol. Microbiol. 1970, 35(4), 207-70 (Km;)* Weanling male rats receiving d*aminopro- piomtrile fumaratc (BAPN) (0.4%) for 3 weeks, and fed an atherogeme diet supplemented with 0.2% BAPN* for 4 weeks, and with D.1% BAPN for 9 weeks exhibited gross ultima! lipidosis of the aorta in as early as 3 weeks. Dissected spaces of the aorta were filled with proliferaimg medial cells, and in the subendothclial rone, the smooth muscle cells were mixed with hpid-ladcn macrophages. Between the test and control animals, none of the major serum lipid fractions were significantly different, thus indicating that latliyrilic changes of rat aortas induce nut only active repair of damaged media but also enhance intimal lipid deposition. CGJN 85992e Histological and histochcmical pattern of the testes of rats exposed to carbon disulfide. Gomlzik, Marian (Potnorska Akad. Med., Szczecin. Poland). /W, Pot. 1970, 21(2), 129-30 (Pol). In rats poisoned by i.p. administration of CSt (12.5 or 25 mg/kg every other day for fM)-l 20 days), regressive, degenerative, anti atrophic changes were obsd. in the spermatogenie epithelium and interstitial tissue when the 25 mg/kg dose was given for more than 00 days. Irreversibility of the changes was postulated. Jerzy Lange 6$993f Pathogenesis of asbestosis. Szytnczykicwicz, Kon rad (Dep. AemsoW, Inst, Ind. Med., Lodz, Poland). Pot. Med. X i. tint. Pull. 1970. PICO, 1 l*r> !!), 138 (Hug). The cry,-it. 'truejure id chrysolite usIh'sIo* (I) and quartz is responsible for ih/ir similar iinvimi-. bi<l. activities. Cry'L. I caused pulmonary chum:cs in r.uiucu pigs eharaclerisiws for asln-siosix whereas nonirplious I did imt. C'ryM. 1 ami- quartz significantly increased the O epnsumidiou of luui' seitious of while mice and the 7* ^hthuliu fraction ol rabbit blood serum compared with controls, amorphous I. i4i*d dust, fiber glas>,f ,im| (orj fine glass. Textile asbestos factory workerx in tlu- spinning and weaving dept*,, which have hicher conens. of longer libers, have u liiglier incidence of asbcstosi' than workers in preparatory depts., wlicre the dust eoiiru. is highest. BCJN 85994g Inhibition of the acute ethanol-induced fatty liver by t>j tarole. NT- r ran. J. C.; l)c Luzio, .Viclmhs U. fSclu of Med.. 1 ,tm l,i.). .W, E'/1. Hin!. Med. 1IJ7(), l.'ll, 1. b>2 d 'b`n:'). Sour pyra/oh- speein* ally imubtvIixir ah. (h hyrirorf iiasr and irnpaiis the jnel.dKiism of KtDJl. . simhes were imflcrUbn in rats to evaluate the influmec of 7 7 iniubttnm of JitOJ! mrial>ohsm on the development oi au'aeull^/'':>, KlOl i-iridue<d !.< 11 y liver. In agreement with previous oilers a* <y` tions. 20 hr after J'lOj] ndimuistraiton a 5-fold increase in hepatic ^ tngbeeride eomn. oeeurretl. In marked conirast, the pyr.izoie. and KiOH-treateil group showed uuutplele inhibition oi FilDM- tnduecd lirpnlic triglyceride accutnuiation. The prevention of the KlOU-mdueed hepatic tnglyrendc acenmulaiioii occurred ' : 11 ` 1 ** *M . -ns. in the pvrn.'olc OLI 4994 I . I ' !'* luui /ii'm- if) vi. y \t jo/o (' ' b.VJdO 103 89 (I.ipnn). J 'lit* t'y toll in i' i l u+s nf hr.tnnr frariinns invi'lill.Ui il Ijy u induigraphy .uni d.'idilc si :iin in I' nn 11 .* 1 with m-iit ml ti-i! mill 11 v i>iii him-. 111--1 om- fi.n tions l-'l, I ' ' J t. I 1'A, mill I'll l'\111. In>111 1 111- r:ilin,l 11 II f 1' In In 11 :r.> Hi i i II 11 \ 11 anil noiicaucer cell (calf thymus) .showed siuul.u m Imty on muu > 1, cells. However, cmly cult mt-ill.l I oil Is (mall in imtt tr.in ifr.i nn'il cells from 1. cells by 1CA In stone l-'I ) recoil nred fumi 1.11 minor w, i c resistant to FI activity fiom KA. One more expt. was cairiul out by using another 3 human cells; 1`llliL Inonniieui-.eiiic), 1'1'H (weakly oncogenic), ami T11EL (strongly oncogenic'. Kveu in this expt. the activity was completely similar to those observed in L and Lll and the cell response to both FI fractions was the highest in T11EL. This gradual activity obtained m every cell was related to the arginine/lysinc ratio of every frac tion with nearly the same amino acid compn. Possible cytotoxic abilities of amino acids and their polymers related to histone were also discussed. Hideo Ruroc 539231 Effects of post-treatment with caffeine on the sensi tivity to ultraviolet light irradiation of two lines of HcLa cells. Wilkinson, Ray; Kiefer, J.; Nias, A. H. W. (Paterson Lab., Christie Hosp., Manchester, Engl.). Mulat. Res. 1970, 10(1), 67-72 (Eng). The effect of UV irradn. was investigated on a std. line of HcLa cells and on a line sensitive to methyl methane- sulfonate (MMS). The MMS-sensitivc line was found to be more sensitive to UV irradn, than the parent line. When the two cell lines were plated in caffeine-contg. medium immediately after UV irTadn., there was no redn. in the surviving fraction of cells of either line, even when toxic conciis. of caffeine were used. RCMR 53929y Synthesis of acid mucopolysaccharides by glial tumor cells in tissue culture. Dorfman, Albert; Ho, Pei-Lee (Dcp. of Pediat., Joseph P. Kennedy, Jr. Mental Retardation Res. Cen ter, Chicago, 111.). Ptoc. Nat. Acad. Sci. U.S. 1970, 60(2), 495-9 (Eng). A clonal strain of rat glial tumor cells produced acid mucopolysaccharides, hyaluronic acid, chondroilin 4-sulfate, and heparin sulfate in tissue culture. The mucopolysaccharides were isolated both from the growth medium and the cells. RCYL 53930s Respiration and glycolysis of cells transformed with 4-uitroquinolinc 1-oxide and its derivative. Sato, Kiyomi; Kuroki, Toshio; Sato, Haruo (Res, Inst. Tuberculosis, Leprosy, Cancer, Tohoku Univ., Sendai, Japan). Ptoc. Soc. Exp. Biol. Med. 1970, 134(1), 2S1-3 (Eng). Hamster embryonic cells transformed in vitro with 4-nitroquinolinc 1-oxidc and its dcriv. exhibited an increased aerobic glycolysis and an inhibition of respiration by glucose addn. in the presence of pyruvate (the Crabtree effect). These changes, which are known to be charac teristic of many malignant cell strains, appear to be correlated with the grade of malignancy. RCTQ ' 53931t Mouse lysozyme production by a monocytoma: isola tion and comparison with other lysozymes. Riblet, Roy J.; Herzenberg, Leonard A. (Med. Sch., Stanford Univ., Stanford. Calif.). .Science 1970, 168(3939), 1595-7 (Eng). A transplant able mouse tumor, GPC`11, produces large amts, of lysozyme- The tumor is a reticulum cell sarcoma, type A, and is a neoplasm of monocytes. The lysozyme was purified from mouse urine in quantities sufficient for structural anal. Comparison of mouse lysozyme with lysozymes front chicken egg white and patients with monocytic leukemia reveals similarities m size and elec trophoretic mobility and, with human lysozyme, in functional properties. However, considerable differences are found in antigenic characteristics and amino acid corapu. RCMH S3932Uffifftollhjto<)Mi)rff-lrGhlgllllli.--Kogan, A. Kh. (Mosk. Med. Inst. itn. Sechcnova, Moscow, USSR). Tr. 1 IPenogol Most. Med. Inti. 1969. 60, 118-23 (Russ). Small capsules ot nylon G, polyethylene, Teflon, polystyrene, polyfEt terephthalate), poly(vinyl chloride), cellophane, rubber, colla gen, fibrin, or glass were implanted into 2100 rats s-c. The eliti. observation of the implants after 12-27 ninnilis showed 31.6' ,', incidence of blastoinogcncsis. The Iii-.li>1. cxanin. of the aiinnr- mal tissues revealed a prc|Htndcrancc nf sarcomas and fewer carcinomas and papillomas. The differences between bl.ninnto- gcuctic activity of the tested materials arc discussed CT'JR 53933V Transport into cytoplasm of nuclear DNA-like RNA in liver regeneration and chemical hepatocarcinogenesis. Plato nov, O.M.; Korotkoruchko, A". P,; Polishchuk, A. S.; Pinchuk, V. G. (Inst, llioehetn., Kiev, USSR). Ckr, Ihnkhim. Zk. 1970. 42(1), 16-19 (likrain). Two fractions of "C-labclcd D.VA-likc RNA (D-RNA-1 and D-RXA-2) were prepd. from isolated rat liver nuclei by thermal phenol fractionation i'G. P. Gvorziev and \*. J.. MantVva, at AA-63 o,i 83. res-. Cyto plasmic RNA irom normal liter lompticd wit.i i>-k.\A-l. but only slightly with Ii-li\A-2, in hybiaiizauon v.iih Ji\A irom liver nuclei, indicatmc that normal l.v* r cytoplasm contains D-RXA-1 but only small amts, of D-RN`A-2. In regenerating liver (24 hr after partial hcpatectoiny) anil cancerous liver (from rats administered dinicthylamitioazobtiizcne for 2 months), hybridization expts. showed the level of cytoplasmic D-RXA-2 to be greatly increased. I. llajek 53934w Effect of a subtraction of carcinomatous rabbit serum li globulin on glycolysis and respiration, Galagnn, N. 1'.; Sii p on lienko, I,. \ .; Clicrnyavskii. Iv. I. (Ips|. itiodicm., Ki<*v, USSR ). like. Ihukhiiii. Ah. 1970, -12(1), 76 Ml fllkraiu), 'J be i ll* i P. ol blood si i iim ploteins of In alt by i alibip. and animals with the Jlrown-Pieftc carcinoma, as will as of 5-globulin, oil the ptoecsscs id glycolysis and respiration were studied. Blood serum of eaieiuoiualuus rabbils, p-glolitiliu, ami one of its subfiaetions (protein positively reading in the sedimentation test for carcinoma, l'PR-STC) evoked a sharp activation of lactic acid formation in nits, of rabbit skeletal muscle. The addn. of healthy rabbit sera to such cuts, decreased the intensity of lactate production considerably. When O absorption of myocardial mitochondria was studied, the addn. of healthy rabbit sera acti vated this process by 32% in comparison with the control and the cancer strum inhibited it almost to the same degree; 6-globulm and PPR-STC inhibited by 59 and 75%, resp. L Hajek 53935x Effect of isogenic lymphoid spleen cells on urethane carcinogenesis in the lungs of Af(B)-strain mice. Kraskovskii, G. V.; Gorelik; L. S. (Inst. Genet. Tsitol., Minsk, USSR). Veplsi Akad. Navuk Belarus. SSR, Ser. Biyal. Kavuk 1970, (2), 109-11 (Russ). Carcinogenesis was produced in mouse lungs by urethane. Lymphoid (splceu) cells were obtained from normal isogenic mice and from those given the urethane. Injection of spleen cells from urethane-treated mice had no effect on the urethane carcinogenesis in the lungs. Spleen Cells from isogenic normal mice suppressed inflammation in the lungs of treated females but stimulated adenoma formation in the males. L. Bakunow'icz 53936y Excretion of unmetabolized 3,4-benzopyrene by rabbits, cows, and hens when it is present in food. Gorelova, N'. D.; Cherepanova, A. I. (X. X. Petrov. Res, Inst. Oncol., Leningrad, USSR). Vop. Onkol. 1970, 10(4), 108-13 (Rnss). Exptl. animals were given food supplements contg. 3,4-bcnzo- pyrene in daily doses of 86 y per rabbit for 5 months, 4.4-434 y per hen for 4 months, 10 mg per cow for 80 days. Unmetabolized 3,4-benzopyrene was detd. in feces and urine once a month (in cows at tiie onset and end of expt.). The content in feces in creased in the rabbits from 0.31% of the daily dose (1st month) to 3.24% (5th month), in liens front 0.2 to 8% (lowest dose level) or from 0.06 to 0.46% (highest dose level). In 2 cows the excretion at the end of expt. was 24.0 and 1.7% of the daily dose. Only traces of the carcinogen w ere found in urine. Most of the compd. was metabolized prior to excretion. However, chronic intake of it altered the metabolic processes and enhanced the proportion of unmetabolized 3,4-bcnzopyrenc in feces. I. Vavra 53937z Cytophotometric determination of DNA in plasmocytic nuclei of the spleen in rats with hormone-dependent tumors. Umanskii, Yu, A.; Antonyuk, R. D.; Gudim-Lcvkovich, K. A.; Lysyuk, L. I'.; Ul'yanova, T. X. (Res. Inst. Exptl. Clin. Oncol., Kiev, USSR). Vop. Onkol. 1970, 16(5), Gl-5 (Russ). Female rats (strain Wistar) were castrated at age 2 months and a part of the ovary was implanted into the spleen. In 10 months after the implantation, tumors of various localization and size de veloped; the rats were then killed and the DXA content in the nuclei of plasmatic cells of the spleen was detd. cytospcctrophotometrically. The DXA content depended on tumor localization with respect to the spleen. In the control animals, animals with tumors in the spleen, animals with tumors developed in other organs but not in the spleen, and animals m which tumors did not develop, the DXA content in each nucleus of spleen plasmatic cells was 2.84, 2.41, 5.09, and 5.72 arbitrary units, resp. V. Kleinwachtcr 53933a Water-salt metabolism in hypophyseal eosinophilic adenoma. Lebedev, A. A. (Ivanov, Med. Inst., Ivanovo, USSR). Zh. Nnrnpalol. Psikhial. im. .1. A. Korsokoia 1970, 70(5), 089-93 (Russ). The atitipyrinc space (general content of water), the hyposulfftc space (extracellular water), Xa and K con tent in plasma, in erythrocytes, ami iu 2 l-hr urine was followed in 18 pnlivnis with )iy|H>physc;d rnsinopltilte adenoma and in 20 healthy subjects ailed 3,' lill yeais. A significantly bigger antipyrine and hypoMillitc space was found iu the patients in accord willi the intracellular edema found in acromegalia. The changes occurred before the tumorous changes iu hypothalamic area. The probability of hypersecretion of hypophysis anterior lobe hormones, resulting in disturbance of the water-salt metabolism, is supported by normalization after x-ray therapy. M. Hava 53939b Tumorigenicity of cyclic nitrosamines in Syrian golden hamsters. Lijinsky, William; Ferrero, A.; Montesano, R.; Wenyon, Charles E. M. (Med. Center. Univ. of Nebraska, Omaha, Nebr.). Z. Krebsjorsc'n. 1970. 74(2), 1S5-9 (lAgi. Oraiiy, inlo.uaZvininic was none jr,.ni<,;caic in luinxurs. v, ..it.1 uitro'Ohept.iinvlhyli-ueiiniiic productd tumors in tin- cs-ipl; > -ns, larnyx, pharynx, nasal cavity, forcstomuch, and trachea. Moat of tiie tumors in the first 4 organs were malignant. Although this latter compd. produced bronchogenic carcinomas in the lungs of rats, this tumor was not induced in hamsters. DC JX 53940v Relevance of chemicobiological interactions for the toxic and carcinogenic effects of aromatic amines. 1. Carcino genic activity of some 4.-aminostilbene and 4-aminobibcnzyl titriv* *7 OLI 4995 41109 Chemical /Wli.ict Vol. 72. 1070 f-tii* 21C 1A--TOXICOLOGY T. K. 10UKKI.M)N 41105X KmSi&m&Bit May! afari4<L>.-*ctoatgk, `mtimiC tUip- toxicity oT vTnyTchloride in animals and hutnans. and the relation of the diem, structure of the compel, to Us toxicity were dis eased. CCJG 4111 Or Microscopically contrasted heavy metal intoxication. Silver sulfide process, a method for localized lustochcmical de tection of heavy metals in tissues. Haider, Gerhard (Gcr.). Mikrokosmos 1969, 58^9), 272-5 (Gcr). A review of work is pre sented which illustrates the value of the combination of light mi croscopy with hiatochcra. techniques for the detection, localiza tion, and identification of lift, Pl>, Hi, J'e, 7ai, and Cu in cells and tissues. Highlights of the silver sulfide htsiochcni, procedure are presented along with representative photomicrographs, (i refs. Nellie G, Oohnhostcl 41111s Development of the hemodynamic, biochemical, and morphologic changes in experimental'endotoxin shock. Sign* gert, Krzysztof (Z Zakl. Ancstczjologii, AM, Lodz, Poland). Postepy Utg. Med. Posts. 1969, 23(5), 601-59 (Pol). A review is given of methods for detg. hemodynamic, biochetn., and mor- phol. changes, the course of changes in dogs, elm. evaluation and patterns, and damage to tissues and organisms during exptl. endo toxin shock. 1*4G refs. V. Pomcranz 411l2t Saponins. Birlc, Yehudith (Hebrew Univ,; Re* hovoth, Israel)- Toxic Const. Plant Foodsl. 1969, 169*210 (Eng). Edited by Liencr, Irvin E, Acad. Press: New York, N.Y. Dietary source, metabolism, and effects of various sapo- nius are given with methods for qual. and quant, analyses. 107 refs. E. A. Hodgriou 41113u Chromatographic identification of psychotropic drugs. Phillips, Geoffrey 1'.; Gardiner, Jane (Lab. Govt. Chem., Lon don, Engl.). J. Pharm. Pharmacol. 1969, 21(12), 793*807 (Eng). The thin-layer chromatog. of 3 clashes of psychotropic drugs, pheucthykiimucs, tryptammes, and crgancs, has been in vestigated. Published methods art* reviewed and Hj data, :i>r- malized by a graphical technique, are retorted for extensions and modifications of some of these systems. Optimum forensic sort ing procedures are recommended. kCHQ 41114v Estimation of lead in urine by atomic absorption analysis. Taira, Yoshiko. Nippon Rittikensa Gishikai Zasshi 1969, 18(5), 389-91 (Japan). The Pb** was extd. into iso-Ilu- COMe soln. from 30/7 NILOII. The recovery rate was 99.0%. The reproducibility of at. absorption measurement was J.4%, No interference from other ions was noticed. T, L. Chang 411l5w Determination of toxic substances and their me tabolites in biological fluids by gas chromatography. I. Tri- ebloroethanol in urine. Sedivec, Vaclav; Pick, Jan (Ustav Hyg. Trace, Prague, Czech.). Prac. Lek. 1969, 21(7), 301-5 (Czech). See CA 70: 1134-tOp, VNJ2 41116x Aflatoxin Bi in the excretion of aflatoxin-poisoned rats. Chou, Ming-Wu; Tung, Ta-Cheng (Coll. Med., Nat, Taiwan Uoiv., Taipei, Taiwan). T'ci-ITon I Msueh Htti Tsa Chih 1969, 68(8), 389-91 (Eng). Aflatoxin Bi was detected in the rot urine and feces after i.p. injection of the toxin. Most of the aflatoxin Bi was excreted in the'first 24 hr. The percentage re covery was about 1.5%. A thin-layer chromatographic method was a simple way for detg. the aflatoxin conen. of the excretions, and could provide useful information for detecting it m humans. N. M. Wright 41117y Paper chromatography of Taxus baccata toxin. Bu- bien, Zcnon (Wyzsza Szk. Roln., Wroclaw. Poland). Zrsz. Nauk. I lysis, S;k. Ruin. Wroda-riu, 1IW, J9(S. Ni. 23. 215-21 (Pol). The presence of toxin in T. hacrata f English yew) medics, in fodder, and m the alimentary tract content w.i* detected by paiKT chromaiog. The alkaloid was c\td. from the bin), ma terial by Et;0, purified witli active C, and chromatographed in the form of aq. HCl <oln. The chromatogram* were developed at 18* by the ascending technique, using as solvent either JhiOIl- 80% AcOII-anliyd. KlOH-UjO (50,7:2:15), or 75'aq (NH):- SO*. The A'/ values were 0.95 and 0.75, resp. The toxin <pot were stained by the Dracrendorf reagent. Irena Kloczko 4111 Sz Errors of converting a urine alcohol value into ?. hlocd alcohol level. Kayr. Sidnc>; Cirdon-* l;',naMo . a j , Iniv. Puerto U;cu, Kin l'iedras, P.K.... .ii..;*-. J. c 1969, 52(5). .'77-84 (Eng1*, Evidence is presented :'ur the in advisability of ealeg. blood KtOH lewis on the basis 01 untie ElOH content, EtOU content was detd. in the blood and urine of Hi> patients and the ratio of urine 'blood was ealed. The range of ratios was 0.21-2.66 wi*h a mean ratio of 1.2S. Blood levels were ealed. from urine levels using a conversion factor of 1.28 and compared with measured valui . Gakd, values ex ceeded actual valns Lj at lea 1 g ml m 21..V*. of the eases and were lower by the same amt. m 54.5' < of the cavs. 411)01 J. K. Maenab {* fumes A.: Scilnjhl, II. R. (Tulam* Uuiv., Covington, La.). Toxicol. AppL Pharmacol. 1969, 15(3), 024-31 (Eng), The toxic efleets of ethylene glycol in several macaque species are re ported. The cornpd. was administered in the drinking water at concns. of 0.25-10%, and histo). studies were made after acute and chronic administration. Witli the exception of a few animals (which had Ca oxalate crystals in the brain), significant pathol. alterations were limited to the kidneys. Animals receiving 15 ml/kg or more of ethylene glycol had Ca oxalate crystals within proximal renal tubules and assoed. tubular degeneration. De spite the absence of crystals in animals receiving <15 inl/kg, mild glomerular damage was found, and azotemia occurred in some animals, suggesting a toxic effect of ethylene glycol apart from its conversion to oxalic acid. KCZU 41l20u A clinicopathologic study of the effects of riot control agents on monkeys. IV. o-Chlorobenzylidene malononitrile (CS) grenade. Striker, G. IS.; Strccit, C. S.; Lord, D. I'.; Herman, L. II.; Holland, D. R. (Edgewood Arsenal, Md.). U.S. Clearinghouse Fed. Set. Tech. Inform., AD 1967, AD-80S- 732, 39 pp, (Eng). Avail. CFSTI. From U.S. Govt. Res. De velop. Rep. 1969, G9(19), 123. A study was made of the order, severity, and resolution of pathol. changes in monkeys exposed to CS. Monkeys were exposed to CS (2700, 8500, 28,500, or 80,000 mg min/rn*). The most prominent lesions seen after the 2 lower doses were mild pulmonary congestion, bronchorrhea, emphysema, and atelectasis. These lesions cleared by 72 hr but recurred at 1 week and 30 days. Oral and nasal discharges and dyspnea appeared early after a level of' 28,500. They were most severe between 12 and 24 hr and were resolved by 72 hr. Pneu monia, emphysema, and atelectasis were present 1 week and 30 tlays after exposure. Significant lesions were seen radiographi cally only in those monkeys exposed to a level of 80,000. These lesions paralleled those seen on necropsy. At this level edema appeared by 12 hr, jicakcd between 24 and 48 hr, and cleared by 1 week. Emphysema and bronchiolitis were present 1 week and 30 d;tvH after exposure. TCVL 41121v Experimental study on gas embolism with particular reference to the differentiation between embolic gas and gas from putrefaction. Picrucci, Giovanni; Ghcrson, Gemma (Inst. Med. Legale, Univ. Pavia. Pavia, Italy). Zacchia 1968. (3} 4{3), 347-73 (Ital). Embolism was induced by injecting hir or He i.v, into living (followed by instant death), and i.v, or imrncardi- ally into sacrificed, rabbits, anil gas was aspirated from the heart at intervals. Putrefaction gas was aspirated from the heart and abdominal cavity of rabbits and human cadavers 1-13 days, and 15-236 days, after death, resp. In samples of air embolic gas, 01 decreased and 1 hr after death was insignificant; COi was present immediately; Nj levels were relatively'stable, similar to air, for 2 days, then decreased sharply. In He embolic gas, Oj, Ns and COj were present immediately. Results were essen tially the same in rabbits injected before and after death. Av. values for putrefaction gas contents in rabbit and cadaver heart were, resp.: O? 1.32 and 2.05%, Ns (usually <50%) 12.13 and 22.00%, CO 31.08 and 50.62%; CH appeared early and almost constantly in the rabbit. F. Farnam 4) 122w Early effects of carbon tetrachloride on the synthesis of phospholipids in the rat liver and their possible pathogenetic role in fatty liver induction. Halbreich, A.; Magcr, J. (Ha- dassah Med. Sell., Hebrew Uuiv., Jerusalem, Israel). Biochim, Bwphys. Acta 1969, 387(4), 5M-7 (Eng). In rats, i.p. injections of CCU in doses as low as 0.5 *d/IU0 g reduced the ability of liver microtomes to incorporate eho!ine-uC into total phospholipids and lalx'led L-Ivucine-/-UL'' into protein, discernible as early as 10-15 111m poHiinjcction and lasting for 20 hr. Incorporation patterns of eliolme wnv identical whether the radioactive choline Was labeled m (lie Me groups or in the 1,2-carboii atoms. The magnitude of choline inhibition was not altered by varying the dose of labeled cliolmc over a 1000-fold range, attesting to the independence of this phenomenon of the attendant variations in the mternai pool size of free choline. Kthionine (l mg g) and diniethyliiitrosamiue (10 mg 'll)*) g) did not u/Teci the incorpora tion of choline into liver phospholipids, although they inhibited protein synthesis. CCh enhanced the incorporation of cthanol- a!llilI',*^"t, *rto liver mierovimal phospholipids. The early ou sel ai.u u*e long |*,r*Uu>iicc.a* weuas thespccuic nature, of the oe- rangemc 111 of phospholipid synthesis by CCL suggest a possible role of tins phenomenon in the pathogenesis in tatty liver. UK IN 41l23x In vitro inhibition of succinate and pyruvate oxidation by ethanolic extracts of grasses, legumes, and dystrophogenic forages. Chcekc, Peter R.; Oldfield, James K. ,Oregon state Uuiv., Corvallis, Oreg.;. Can. Sci. 1969. 49< 1), h>J*4 (F.neb KtOH e\ts. of title plants inhibited m viim ovuln. 01 bith succinate ami pyruvate by rat h\er hotiiogvn.ites. hxt**. oi 2 dystrophogenic foraves did not inmhit succmai** oxm',. mor^ OLI 4996 ijiM''- The niajin ii> Irrviice li< s in tin* l.ir/ci iii'iiuii'niiin i* tM.tv 1,-111-I111 fmtor., tmi nrl(<, aiily hisinm ,, whitli affet t gene ` ,i;,i*Miriits of tin1 in,him :ltic !*> il-, lu/ln r nt('i,,b.<}i. mi. uvilv in n iMriHui I lh.il m not *.pf t irs s|H-i ihe. RKJN 1 Philip l:i* itl* mt lltlSfjOr Cliniigr , m lln1 nrlivity of i'.ol.ited vascul ii smooth Levels of miimiuorJiibiiliiiu ,-,A I in iim.ii.lt tnir cle in 1111 ponxo io ii iJm i-d o.smohiiily. Jiiii,,,`,oii, < i|,,f (Ihiiv. ilicn. `In 1 j.i 1.1, Jfili.i Ini" iKiiii" l'niv.. 1.\ i, I.ijiin i. iL, t, Imi, ( h-ti-lini j., Sn, d, i. Ailn rlinml. .'uuml. ldtid,77fl), ,,2,i Ai.vo 1908, 14(6), 379 SC. ilmc). Level- ill fimin ibl 2db (Hid:), `I lie cllii is of hypnuxninlarUy on the .s[ion- ntim'glohnlms win o ill lit. by l!n antibody ;irar pl.ue iiictlind m I:\iivoiis activity of the smooth muscle m the isolated portal vein ami rortl bb'i'tl at the utile nl delivery anti in i'.rmi|i , nf . filial infant1' ami t'lnlilri'ii up tn aj'.i* 15. xA ini'. ab'-cnt imiu :,l blood, iM present inily in tuues In ri is (hr It vi k nl of iln i,n have h, cn *n ml led m si 4 ns. w itli varied mine eutitpn. A comparison beivvi en ibe stiiiml.iioiy effeels of lowcn-d osmiilaiity and inereased [K'lo fexn rnal K* coiien.) indicated that at Vioitl blood wore equal to nr above those m maternal blond, normal |K'*|,, in the i-nutra! slate the excitation caused by hypo tj annum levels of yG were found at 3 and 0 months, then rose tonic Uy is not mediated only via changes in the (K.+ ] ,/[ls11 ]o ratio. V.'l)'i not attaining the adult ranee until are 11 Levels of -,M The response to liypnusinolanly at a higher |1C*Ji> is, however, lurlicd half the ranee found in adults by 3 months, but did not more readily explained by the change in |>Cli/[K.*|o which ff*di adult levels until 3 yrs. Levels of -yA were less than half occurs in assocn. with the swelling of the cells. This might be J'f adult range tip to ace 5, then rose rapidly. Jacob Sachs attributed to the fart that the membrane potential of smooth 110564k Polymorphism of transferrins of bovine, porcine, and muscle is more dcpcndint on the transmembranc coma, gradient :iaine sera, as determined by means of aerylamide-gcl disc for K + at higher levels of [K+l. The stimulatop' effects of bypo- dectrophoresis. Dorner, Joseph L. (L'niv. of Illinois, L'rbana, osmolarity are markedly reduced at a low (Na+K but are not 1968, 66 pp. (Eng). Avail. Umv, Microfilms, Ann Arbor, considerably affectctf by comparable redns. in [K.*) or (Cl*),. ybih., Order No, G9-10,G87. From Viss. Abstr. B 1969, 29(12), This indicates that the transmembranc Na+ gradient is involved i;:7. SNDC in the mechanisms by which hypoosmolarity excites the spon 113565m Hemoglobtn-Lepore Baltimore, a third type of a b$ cessover (<", 0")- Ostertag, Wolfram; Smith, Ernest Wendell eh. of Med., Johns Ilupkms L'niv,, Baltimore, Md.), Eitr. J. >,srtern. 1969, 10(2), 371-G (Eng). A new Lepore-type Hb in a -xrson of Negro descent has been identified. In this person a r. nor Hb (Hb-Lcporcu.it,m,,>) was detected. An abnormal M-ehain was isolated and fingerprinted. This hybrid-type pro ton presumably arose as a consequence of unequal crossing over txtmccn the f and 0 genes, as was concluded for Hb-LeporCB.,,,,,n s-.d Hb-Lcporcn0inn,ii.. In the new Lcporc-typc lib described ;,rre the crossover could be placed between residues 4H and This type of crossover should occur with the highest frequency if crossing over is equally frequent between any nucleotides and if iclcctinn favors none of the crossover types. RCI1Y 110566n Genetic and developmental regulation of hepatic Paininolevulinate dehydratase in mice. Doyle, Darrell J.; fvhimkc, Robert T. (Sch. of Med., Stanford L'niv., Stanford, Calif,), J. Biol. Chew. 1969, 244(20), 5449-59 (Eng). The cterliamsm by which the lcvulinatc locus (Z.;1) regulates the tissue s. tivity of 4-aminolevuIinatc dehydratase in mice has been exaiud. The assayablc hepatic enzyme activity in homozygous it* mouse strains, represented by C57B1/G, is between one-third and oiic- half that of homozygous Lt* strains. This difTcrence in enzyme activity is due to a difference in amt. of enzyme protein as demon- itratcd by immunochem. techniques with an antibody specific for f-aminoievulinatc dehydratase. Combined imiimiiochciii, and ivitopic techniques show that the lcvulinatc locus regulates the toacn. of hepatic 5-aniinolcvulinate dehydratase by acting at the level of enzyme synthesis. The rate of degradation of hepatic eatyme is the same in both low and high activity strains; when 'pressed as a half-life, this is equal to 5-6 days. The pattern of Lsiuinolevulinatc dehydratase development with age is similar a livers of both low and high activity strains. The specific setivity of the enzyme is high in fetal liver, decreases during the wvcral days prior to birth, and increases to the adult level during tt* first 3 weeks of postnatal life. The activity of 4-aiirno* lrvulinatc dehydratase in fetal liver is also regulated by the sntlinate locus. The enzyme in fetal liver is approx, twice as zrtive catalytically as the enzyme iu adult liver relative to its inaction as an antigen. The fetal enzyme also appears to be Strent in stability to heat and proteolytic inactivation. How* *i`cr, fetal and adult enzymes are similar by other physiochem. taneous activity of vaseular smooth muscle. One possible interpretation is that the swelling of the muscle cells iu hypotonic solus, causes an increase in the permeability of the cell membrane to the relatively larger Na+. KCVV 110S70J Secretion of tat panereat perfused with plasma from rats fed soybean trypsin inhibitor. Khayambashi, H.; Lyman, R. L. (Univ. of California, Berkeley, Calif.). Anitr. J. Physiol. 1969, 217(3). 646-51 (Eng). When plasma from rats fed soybean trypsin inhibitor was perfused through an isolated, fasted rat pancreas, amylase secretion was 2-3-fold greater than that of a pancreas perfused with plasma from rats fed the same diet without trypsin inhibitor. Addit. of atropine to the perfusate did not inhibit the secretory response. The plasma fac-Lor was relatively unstable upon storage at 4* (50% loss of activity in 4 days) and appeared to be assoed. mainly with those plasma proteins of 10,000 mol. wt. or less. Thus, active soybean trypsin inhibitor enhanced the formation and (or) release of a humoral pamreozy- minlikc substance that markedly stimulated external enzyme secretion of the rat pancreas, KCD1I 110571k Effects of diet and catechol amines on bile acid metabolism in dogs. Gans, Joseph H.; Cater, Marilyn R. (Coll, of Med., Univ, of Vermont, Burlington, Vt.). Amer. J. Physiol. 1969, 217(4), 1018-24 (Eng). Five adult male dogs were surgically prepd. with polyvinyl tubing placed iu the upper duodenum. Each dog was given cholic-ear6axyf-1,C acid and samples of gallbladder bile were withdrawn over a 10-day period. The laurocholic acid pool was 1.09 g./lO kg. body wt. and half, life was 3.2 days when dogs were given a dry dog food diet. Epinephrine in oil, 0.8-1 mg./kg./day, increased plasma cho lesterol concns., produced a 23.9% redn, in the laurocholic acid pool Size, and increased the rate of decline of specific radioactivity of both taurocbolic and taufodcoxycholic acids. The half-life of taurocholic-uC acid during epinephrine administration was l.G days. Norepinephrine iu oil, 0.8-1.0 mg. free base/kg./day, produced a modest decrease in the half-life of taurocholic-l,C acid without significant elevations in plasma cholesterol concns. A dietary supplement of'/, lb. beef plus 2-3 g. of cholesterol per day resulted in increased plasma cholesterol concns., increases in the laurocholic acid pool size, and a decrease in the half-life of taurocholic-"C acid. Epinephrine administration further in creased plasma cholesterol concns. in cholesterol-fed dogs, but did not significantly alter bile acid metabolism. RCDH 110572m Effect of osmolarity on canine renal vaseular j',1.1, 'nc*uding electrophoretic mobility, sedimentation cneff., saa A, for the substrate. RCJV resistance. Gazitua, Sergio; Scott, Jerry Benjamin, Chou, Ching-Chung: Haddy, Francis J- (Michigan State Univ., East 110567p Identification and genetic control of two new low* Lansing, Mich.), /liner. J. Physiol. 1969, 217(4), 1216-23 4entity lipoprotein allotypes: phenogroups at the Lpq locus- (Eng). The effects of changes in renal blood osmolarity, pro 'lovrj, John J.; Dray, Slicidon (Med. Center, L'niv. of Illinois, ^jeago, 111.). J. Immunol. 1969, 103(2). 153-02 (Eng). Sec u : lW403z. VN'JZ duced by close intraarterial infusion of solus, of dextrose, NaCl, and urea, on renal resistance were systematically exaiud. in the dog. Infusion of a hyperosmotic soln. of dextrose for 3 inin. , ,,0S68tj Modification by crude histones of gene activity for produced a fall in renal vascular resistance which was sustained dehydrogenase. Lamer. A. L,; Longstaff, II. (Roy. for the entire mtusion period. On termination of the infusion, *tria Infirmary, Newcastle upon Tyne, Engl.;. .YjHire resistance returned to the control level. Iniusion of a soln. of i*69- 224(3214), 71-3 (Eng). Aririti. of crude calf hyperosmotic XaCI or urea, on the other hand, produced a fall in | )nius histone to the mouse kidney organ culture increased the resistance winch waned with time. Furthermore, on stopping 1' 'iswtion of the lactate dehydrogenase 11.1) 11) i-nzymes wbieb the infiisiim, resistance transiently rose well above the control It 'TM 7'rc rapidly toward the anode during electrophoresis, level, particularly in the case of urea. Intraarterial infusion of t-tvdc rat liver histone fraction w*as added to the culture, the an isosmotic soln. of urea and of hyposmotic solns. of all three o Jsg was in the direction of the slowgr moving LD11 i-or\ m -s. substances produced Infee increases m resistance. Studies con- ,J ciijri-ri s ( 1".(:1-\Ld to th-* crod'j rail (heirm- t-., - ' e ,'prjt|M., lyiuprintic ws-vl pressure and ccll-lrce perfusion, as vdl y;t of Lilli.1 and the 11 subunit lei-Ui'Jiuio.i io i , i u.d as lbs li.uuius s>i ot.icis, are consistent with, the hypoihe-.. tu.it yactivity significantly increased, sviicrsas me opposite was the changes tit rv'i-tatice result, to a Large extent, from active with the rat b\cr histone prepu.; LL)il-."> and the M sub- var.amutiou. possibly due to osmotic changes in the water content , . l,|dnficaiitly increased. Enrichment ol the medium with of the smooth tnusciu cells. KClJli t. .j"J 1C1IJ present in the calf thymus histone prepn. did not 110573n Metabolism of ally) compounds in the rat. Clapp, :tt *le lsoIFme pattern, indicating that the changes in LD1I J. J.; Kaye, C. M.; Young, Leslie (St. Thomas's fiosp. Med. P'tfn Here.,,0t causeif by hydrolysis of the histone. Gene Sell., London, Engl.). Jhorhem. J. 1969, 114(1), GT-Tl' (Engl. `ng by histones apparently is nonspecific, and the crude ext. A mcrcapturic acid was isolated from the urine of rats treated s.c- ?/ // (7 .v ? vt OLI 4997 VINC.IUSTINI'. DRUGS AMD CHEMICALS 3i PRESCHOOL/ CORTICOSTERONE. On-ripnulie UAe/ OVCLOPHOMMtAVmK. advert CVCLOniO.sriZAMlUF. therapeutic urn/ FEMALE/ HUMAN/ INFANT/ JAUNDICE, chemically induced/ LEUKOPENIA, chemically Induced/ MALE/ RKTlCULOENnOTHELIOSIS, drug therapy/ SULFATES/ VINBLASTINE, adverse effects/ `VINBLASTINE, therapeutic use/ VINCRISTINE, adverae effects/ VINCRISTINE, therapeutic tue 4739. Combination chemotherapy (MOPP) in the management of advanced Hodgkin's diseaac. A prorroaa report on 55 patient* Cooper IA. t al. Med J Au*t 1:4)4, 9 Jan 72 ADOLESCENCE/ ADRENAL CORTEX HORMONES, therapeutic use/ ADULT/ BENZOATES, therapeutic vie/ BONE AND BONES, radiography/ DRUG COMBINATIONS/ FEMALE/ *!I0DGK1N*S DISEASE, drug therapy/ HODGKIN'S DISEASE, pathology/ HODGKIN'S DISEASE, radiotherapy/ HUMAN/ LIVER FUNCTION TESTS/ LUNG, radiography/ MALE/ MECIXLORETKAMINE, administration A dotage/ ICECHLORETHAMINE. adverae effects/ MECHLORETHAMINE, therapeutic uee/ MIDDLE AGE/ PREDNISOLONE, admlBiitretion 4 doaaie/ PREDNISOLONE, adverse effects/ `PREDNISOLONE, therapeutic use/ PROCARBAZINE, administration 4t dosage/ PROCARBAZINE, adverse effects/ PROCARBAZINE, therapeutic uae/ VINCRISTINE, administration 4 dosage/ VINCRISTINE, adverae effects/ VINCRISTINE, therapeutic use 4799. (Vlncrlatlne*indueed encephalopathies during treatment of childhood leu*emus] Gr9be H, et ai , Moustaaebr HlotftrhsUkd 120:23-7. Jan 72 (Eng. / Abatr.) (Qer) ALBUMINURIA/ CENTRAL NERVOUS SYSTEM, drug effecU/ CHILD/ CHLORIDES, blood/ `CONVUiAIONS, chemically induced/ ELECTROENCEPHALOGRAPHY/ ENGLISH ABSTRACT/ FEMALE/ HUMAN/ `LEUKEMIA. LYMPHOBLASTIC, drug therapy/ POTASSIUM, blood/ SODIUM, blood/ SPECIFIC GRAVITY/ UNCONSCIOUSNESS, Chemically induced/ UREA, urine/ URINE/ `VINCRISTINE, adverse effects/ VINCRISTINE, therapeutic use 4790. Vincristine neurotoxicity. Walden PL, et aL N Bui t Med 244:1349-70, 22 Jun 72 HUMAN/ MALE/ MIDDLE AGE/ `MUSCULAR ATROPHY; complication!/ `NERVOUS SYSTEM, drug effect!/ NERVOUS SYSTEM DISEASES, chemically induced/ PARAPLEGIA, chemically Induced/ PARESTHESIA ehemtcally induced/ TERATOID TUMOR, drug therapy/ TESTICULAR NEOPLASMS, drug therapy/ `VINCRISTINE, adverae effect! 479L Ionising radiation and vincristine: possible neorotoxle synergism. Byfield JE. Radiol Cite Biol 41:129-31.1972 COBALT ISOTOPES, therapeutic use/ CYCLOPHOSPHAMIDE, administration 4 doaag*/ CYCLOPHOSPHAMIDE, therapeutic nee/ DRUG SYNERGISM/ HUMAN/ INFANT/ v INFANT, NEWBORN/ MALE/ MEDIASTINAL NEOPLASMS, drug therapy/ MEDIASTINAL NEOPLASMS, radiotherapy/ `MYELITIS, etiology/ NEURAL CONDUCTION/ NEUROBLASTOMA drug therapy/ NEUROBLASTOMA radiotherapy/ RADIATION-SENSITIZING AGENTS/ RADIOTHERAPY DOSAGE/ `RADIOTHERAPY, HIGH ENERGY, adverae effects/ VINCRISTINE, administration A deeage/ VINCRISTINE, adverae effects/ VINCRISTINE, therapeutic use 4792, {Studies on the neurotUlclty of vincristine in the course of infantile leukemia] Mira L. et al. Rlv Patet Ntrv Mom 91:139-44, Jun 70 (Kng. Abatr.) <IU> CHILD, PRESCHOOL/ DRUG TOLERANCE/ ENGLISH ABSTRACT/ FEMALE/ HUMAN/ LEUKEMIA drug therapy/ MOTOR NEURONS, drug effect*/ `NERVOUS SYSTEM DISEASES, chemically induced/ QUADRIPLEGIA, chemically induced/ VATF.R'S AMPULLA drug effect*/ `VINCRISTINE, adverse effects VINYL COMPOUNDS POISONING 4743. [Pathogenesis of the changes developing in long-term A-364 exposure to vinyl chloride) lUaalaev AV. el al Clg Tr Prof Zahol 14:24-7, Feb 72 (Eng. Abatr.) (Ilu*> `ALKENES, poisoning/ ANIMAL EXPERIMENTS/ ARTERIES/ BLOOD PRESSURE/ RONE RESORPTION, chemically induced/ CEREBRAL CORTEX, physiology/ CHLORIDES, poisoning/ ELECTROCARDIOGRAPHY/ ENGLISH ABSTRACT/ HYPOTHALAMUS, physiology/ PHONOCARDIOGRAPHY/ PULSE/ RABBITS/ BATS/ VINYL COMPOUNDS, poisoning TOXICITY 4794. A laboratory model for behaviour as an indicator of toxicity. SUverman AP. Clha pound Study Group 35:25-40, 1970 ACETATES, toxicity/ ALKENES, toxicity/ ANIMAL EXPERIMENTS/ `ANIMALS, LABORATORY/ `BEHAVIOR. ANIMAL, drug effects/ CHEMICAL INDUSTRY/ DISEASE MODELS. ANIMAL/ ENVIRONMENTAL EXPOSURE/ HUMAN/ MALE/ NICOTINE, administration a dotage7 NICOTINE, toxicity/ HATS/ SMOKING/ SOCIAL BEHAVIOR, drug effects/ TAPE RECORDING/ -TOXICOLOGY/ VINYL COMPOUNDS, toxicity 4749. [Toxic effect en the organism of simultaneous air pollution by vinylacetate and acetaldehyde] Prtsiaxhniiik VE. Gig Saxlt 19:13*4, Dec 71 (Eng. Atstr.) (Re*) `ACETALDEHYDE, toxicity/ ACETIC ACIDS, toxicity/ `AIR POLLUTION/ `ALKENES, toxicity/ ANIMAL EXPERIMENTS/ ENGLISH ABSTRACT/ ENVIRONMENTAL EXPOSURE/ HUMAN/ MAXIMUM PERMISSIBLE EXPOSURE LEVEL/ RATS/ TIME FACTORS/ VINYL COMPOUNDS, toxicity VIRAL VACCINES . ADVERSE EFFECTS 4794. Joint symptoms following en area-wide rubella Immunisation campaign-report of a survey. Wallace RB. et ai. Am J Public Health 42:439-41, May 72 AGE FACTORS/ ANTIBODIES, analysis/ CHILD/ CHILD, PRESCHOOL/ COMPARATIVE STUDY/ FEMALE/ HEMAGGLUTINATION INHIBITION TESTS/ HUMAN/ JOINT DISEASES, blood/ `JOINT DISEASES, etiology/ JOINT DISEASES, Immunology/ MALE/ NEW YORK/ PAIN, etiology/ RETROSPECTIVE STUDIES/ RUBELLA, Immunology/ `RUBELLA, prevention 4 control/ RUBELLA VACCINE, adverae effect*/ `RUBELLA VIRUS/ SCHOOL HEALTH/ TIME FACTORS/ `VIRAL VACCINES, adverse effect* 4747. Bronchial sensitivity to methaehollne after Uvor rubella vaccine immunisation In asthmatic children. Tuchlnda M, t al- Ann Allergy 30:142-5, Mar 72 ADOLESCENCE/ ANTIBODIES, analysis/ `ASTHMA, immunology/ CHILD/ FEMALE/ HEMAGGLUTINATION INHIBITION TESTS/ HUMAN/ MALE/ `MGTHACHOLINE COMPOUNDS, diagnostic use/ RESPIRATORY AIRFLOW/ `RESPIRATORY HYPERSENSITIVITY, diagnosis/ RUBELLA VACCINE, adverse effects/ `RUBELLA VIRUS, Immunology/ `VIRAL VACCINES, adverse effects 4749. Inch of significant oncogenicity of biological products in hamsters. Cox CB, et xl. Appi Microbiol 23:473-4, Apr 72 ADENOMA, chemically Induced/ ADENOVIRUS/ ADRENAL GLAND NEOPLA5MS, chemically Induced/ ANIMAL EXPERIMENTS/ ANIMALS. NEWBORN/ BACTERIAL ANTIGENS, adverse effects/ BACTERIAL VACCINES, adverse effects/ `BIOLOGICAL I'KomiCTS, silvern* effecl*/ CARCINOGENS/ DISEASE MODELS. ANIMAL/ FEMALE/ HAMSTERS, drug effects/ NEOPLASMS, EXPERIMENTAL, chemically Induced/ ORGAN SPECIFICITY/ PREGNANCY/ SV40 VIRUS/ TOXOIDS, adverse effects/ VIRAL VACCINES, adverse effects 4749. Clinical reactivity and lmmunogealeity of hemagglutinin Influenza vaccine. II. Clinical reactions. hcmagfilut-lasUoO'lohiblllong and strain and type-specific complement-fixing antibody responses Id infants. ZJvadov* H, et xl. Arch Geiamte Vlrusferach 39:33-4), 1972 ANTIBODIES, analyst*/ ANTIBODY OLI 4998 POLYSTVRENKS DRUGS AND CHEMICALS blowl/ HUMAN/ llY1>?lO(.KN |ON CONCKNTKATION/ IIYPKOXIOLS. administration & dosage/ JiYOItOXIDFS, Adverse effects/ *ION EXCHANGE KKS1NS. Administration it dosage/ ION EXCHANGE RESINS, adverse effects/ "MAGNESIUM, administration A dosage/ MAGNESIUM, adverse effects/ MAGNESIUM, blood/ MALE/ POLYSTYRENES, administration & dosage/ POLYSTYRENES, adverse effects/ POTASSIUM, blood/ SULFONIC ACIDS, administration A douge/ SULFONIC ACIDS, adverse affects ISOS. (Evaluation of color perception disturbances in apprentices In a chemical plant producing butadiene-styrol-rubberand polysterol j Klein O, et ai. Z Gesamte Hyg 17:492, Jul 71 (Grl ADOLESCENCE/ 'BUTADIENE, adverse affects/ 'COLOR PERCEPTION/ COLOR PERCEPTION TESTS/ FEMALE/ HUMAN/ INDUSTRIAL MEDICINE/ MALE/ 'OCCUPATIONAL DISEASES, diagnosis/ POLYSTYRENES, adverse effects/ 'VISION DISORDERS, chemically induced POLYURETHANES TOXICITY M07. Toxicity of iwt released by potjwthiH foams objected to sufficiently hlfb temperatureYamamoto K, ot *1. Jap 3 Lot Med 25:303*14, 3ul 71 ANIMAL EXPERIMENTS/ CARBON MONOXIDE, blood/ CARBON MONOXIDE POISONING/ CYANIDES, blood/ CYANIDES, poliOBIBf/ `GAS POISONING, etiology/ GAS POISONING, morality/ -HEAT/ HEMOGLOBIN, analyst*/ MALE/ OXYGEN, anaiysl*/ POLYURETHANES, toxicity/ HATS POLYVINYLS ADVERSE EFFECTS Xttt. (Bebxvter of tbo human liver CurInf .lileo.1. therapy enlnf polyvlaylpyrldloo-N-oxlde (PVNO)] Sui p, ot XL Bellr SllUoseftrack 23.-41-100, 1271 (Ebr. Ab.tr.) (Her) BIOPSY/ ENGUSH ABSTRACT/ HUMAN/ LIVER, meUbolltm/ LIVER, phyttopitbolofy/ MALE/ OXIDES/ POLYVINYLS, adverse effect./ POLYVINYLS, moaboliim/ POLYVINYLS, tberipeutle us*/ PYRIDINES. advene elfeeu/ `PYRIDINES, moabolttm/ PYRIDINES, therapeutic use/ SILICOSIS, dm* therapy/ TIME FACTORS MOO. Eotoroeotlils followtuf .xcb.nl. transfusion. Sapar MUaeot 2:1203*4, 27 Nov 71 BICARBONATES, advorvo ofloctx/ ENTEROCOLITIS, ACUTE, etlolofy/ EXCHANGE TRANSFUSION, adverse offoeu/ HUMAN/ INFANT, NEWBORN/ `INFANT, NEWBORN. DISEASES, etlolofy/ POLYVINYLS, xdvorxo effecu BUS. Ptaxtletxon ta P.V.C. and the occurrence of hepatltlx la a haemodlalyala salt. A preliminary communication. Neerfaard J, et at. Scaud 3 Urol Nephrol 3:141-3. 1371 ADULT/ AMINOTRANSFERASES, blood/ ANTIGEN-ANTIBODY REACTIONS/ BILIRUBIN, blood/ CARBON TETRACHLORIDE, analyila/ DYSPNEA, ebomleally iadueod/ FEMALE/ FEVER, chemically Iadueod/ GLOMERULONEPHRITIS, complications/ GLOMERULONEPHRITIS, therapy/ `HEMODIALYSIS/ 'HEPATITIS. TOXIC/ HEPATOMEGALY, chemically Induced/ HUMAN/ KIDNEY FAILURE, CHRONIC, therapy/ LACTATE DEHYDROGENASE, blood/ LIVER, patnolofy/ MALE/ NAUSEA, ehefnlcally Induced/ NEPHRECTOMY/ PAIN, chemically lodaexd/ PHTHAL1C ACID, adverae effect!/ POLYVINYLS, advene effect*/ POLYVINYLS, analyst*/ POSTOPERATIVE COMPLICATIONS TOXICITY Mil. Deoeolltu fellewlnf eicbanic transfusion. McCasdleu AE Laacti 2:752, 2 Oct 71 COLITIS, etloloxy/ `EXCHANGE TRAKSr'USION. adverae rffeett' HUMAN/ `ILEITIS, *llolo*y/ POLYVINYLS, toxicity A-290 POTASSIUM ADVERSE EFFECTS 3412. Scable.. Wllaoo 3W. Arch Dermatol 104:223, Auf 71 BIOPSY/ FECES, dray cffccta/ HUMAN/ `HYDROXIDES, adverse ctfocta/ INDICATORS AND REAGENTS/ POTASSIUM, advene effect*/ `SARCOPTES SCAB1EI, drux effecu/ `SCABIES, dlafaexlx/ SODIUM CHLORIDE/ SOLUTIONS MIX [Sodium dust effect! and elimination procedures la tbe respiratory tract) Galle . et al. Z Erkr Aimanyioriaac 134:459-70, 1971 (Ger) ANIMAL EXPERIMENTS/ `DUST/ ENVIRONMENTAL EXPOSURE/ ENVIRONMENTAL POLLUTION/ INDUSTRIAL MEDICINE/ NASAL MUCOSA, druf effect*/ NASAL SEPTUM, drux effect*/ NOSE. Mcrouea/ PHAGOCYTOSIS/ POTASSIUM, adverse effeou/ RABBITS/ `RESPIRATORY SYSTEM, drux effecu/ `SODIUM, adverae effecu POISONING M14. Treatment of eauntie alkali polaonlnf. Arooa 3M. Mad Treat 0:013-3. Auf 71 (li ref.) ACCIDENTS, HOME/ ACETIC ACIDS, tborapeutie ml ADRENAL CORTEX HORMONES, therapeutic uae/ 'ALKALIES, peuoatax/ BURNS. CHEMICAL, etlolofy/ BURNS, CHEMICAL, therapy/ CARBONATES, polaonlnf/ `CAUSTICS, polaonlnf/ DILATATION/ ESOPHAGOSCOPY/ ESOPHAGUS, Injuries/ EYE BURNS, etlolofy/ EYE BURNS, therapy/ HUMAN/ HYDROXIDES, polaonlnf/ IRRIGATION/ PEROXIDES, pntsonlnf/ POTASSIUM, polaonlnf/ PREDNISOLONE, therapeutic use/ REVIEW/ SODIUM, polaonlnf/ SODIUM HYDROXIDE, polaonlnf/ SODIUM HYPOCHLORITE, polaonlnf POTASSIUM CHLORIDE ADVERSE EFFECTS MIS. [Arrhythmias. 3. DifHalls Induced arrhythmia] Bertler A. at aL Lakartldnlhfaa M:Suppl II:U-, 14 dun 71 ftwal ADRENERGIC BETA RECEPTOR BLOCKADER5, therapeutic au/ ANTIDOTES/ ARRHYTHMIA, Chemically Induced/ ARRHYTHMIA, druf therapy/ CALCIUM, thorapoaue uae/ `DIGITALIS GLYCOSIDES, advene effecu/ DIGOXIN, advene offoeu/ DIPHENYLHYDANTOIN, therapeutic use/ HEART CONDUCTION SYSTEM, druf eftecu/ HUMAN/ UDOCA1NE, therapeutic as*/ POTASSIUM CHLORIDE, advene effecu , Mil. [Uaa of poUaslnm chloride la cardlovatcular disease.] KoU taL foe Mad 33:102-4. Nov 70 (Enf. Ahatr.) (Real ADMINISTRATION, ORAL/ ADULT/ ARRHYTHMIA, chemically laduced/ CORONARY DISEASE, druf therapy/ DYSPEPSIA, chemically laduced/ ENGUSH ABSTRACT/ FEMALE/ HEMORRHAGE. GASTROINTESTINAL, chemically Induced/ human/ intestine, small/ male/ MIDDLE ACE/ POTASSIUM CHLORIDE, administration * donate/ 'POTASSIUM CHLORIDE, advert* effect*/ 'ULCER. Chemically Induced POWDERS ADVERSE EFFECTS MI7. FraphyUxt* of wound Infection. Stoker TA. ot at Br Med 3 3:762, 25 Sep 71 AMF1C1LL1N. therapeutic uae/ ANTIBIOTICS, advene effects/ `ANTIBIOTICS, therapeutic uae/ CLINICAL RESEARCH/ HUMAN/ POWDERS, adverse effecu/ SUPPURATION, Chemically Induced/ `SURGICAL WOUND INFECTION, preventive A control/ UREA, adverae effecu/ `UREA, thonpoutle use PREDNISOLONE ADVERSE EFFECTS Mil- [Steroid Induced fUueoma] Seto N. Acta See Ophihalmel lap 75:1243-96. 3un 71 (Enf. Ahatr.) (japj ADULT/ ACE FACTORS/ BETAMETHASONE, advene effecu/ CHILD/ CORTISONE, advene OLI 4999 DRUGS AND CE iEMICALS I'ICKDNISOl.ONK POISONING 3424 [Toxic if igr>Ht|n.-il i||i4fcc mi<l polyvlnyiRlonc chlnrltlr] Krlcrcr J, rl al. lift OlnururtKiplilalmol 43:64-8, J*n-Fcb 71 (Fret ADULT/ HUMAN/ MAM;/ `POLYNEURITIS, etiology/ `POLYVINYLS, poisoning/ trigeminal nerve TOXICITY 1425. (Detoxicating effect* of poIy-2-vlnylpyrldlne-N-oxJdc) Atitvvelirr II. Deltr SUikoscfOrjCh 2293 172, 1870 (Gerl ANAPHYLAXIS, drug therapy/ ANIMAL EXPERIMENTS/ `ANTIDOTES/ CARBON TETRACHLORIDE POISONING, prevention A control/ ENGLISH ABSTRACT/ ENZYME TESTS/ ERYTHROCYTES, drug effect!/ PISHES/ PUNGJ/ GUINEA PIGS/ HEMOLYSIS/ MICE/ OXIDES, pharmacodynamics/ OXIDES, therapeutic use/ POISONING, druc therapy/ POLYVINYLPYRROLIDONE, pharmacodynamic*/ `POLYVINYLS, pharmacodynamics/ POLYVINYLS, (herapenilc use/ POLYVINYLS, toxicity/ "PYHIDINKS. pharmacodynamics/ PYRIDJNKS. therapeutic use/ RABBITS/ RATS/ SILICA. anUgoalst* A inhibitor*/ SILICOSIS, drug therapy/ SILICOSIS, prevention A control/ SWINE/ URETHANE, pharmacodynamics POTASSIUM ADVERSE EFFECT* 8426. (Relationship between the extracellular potassium concentration, electrocardiographic excitatory .processand functional cardiac capacity] Schwanbach '' W. Arch Krettlaufforsch 63:123*51, Nov-Dee 70 (Gerl ADMINISTRATION, ORAL/ ADULT/ AGED/ ARRHYTHMIA, chemically Induced/ CARDIAC OUTPUT, drug effects/ CARDIAC VOLUME, drug effeetj/ DIURETICS, diagnostic use/ ELECTROCARDIOGRAPHY/ ENGLISH ABSTRACT/ `HEART, physiology/ HEART CONDUCTION SYSTEM, drug effects/ HEART FAILURE, CONGESTIVE, blood/ HEART FAILURE, CONGESTIVE, complications/ HEART FAILURE, CONGESTIVE, phytopathology/ HEART FUNCTION TESTS/ HEART RATE, drug effects/ HUMAN/ HYPOKALEMIA, complications/ HYPOKALEMIA, phytopathology/ MIDDLE AGE/ POTASSIUM, advert* effects/ POTASSIUM, blood/ POTASSIUM, diagnostic use/ POTASSIUM, pharmacodynamic*/ STATISTICS Silt. Low sodium diet. A persona) experience el IU benefit* end pleasures. Youngstrem KA. J Kens Med Sec 72:243-4, Jun 71 CEREBROVASCULAR DISORDERS, therapy/ CHLOROTHIAZIDE, adverse effects/ `DIET, SALT-FREE/ HUMAN/ METKYLDOPA, adverse effect*/ POTASSIUM, adverse effects fill. The effect of potassium perehlerate on the uptake of 99mTc-pertechneUte in ehoroid plexus papillomas: a report of two eases. Fagan JA. *t si. i Nud Med 13:312-4, Jun 71 CEREBRAL VENTRICLE NEOPLASMS, diagnosis/ CEREBRAL VENTRICLE NEOPLASMS, metabolism/ CHILD/ `CHOROID PLEXUS, metabolism/ DEPRESSION, CHEMICAL/ FEMALE/ HUMAN/ INFANT/ MALE/ `PAPILLOMA, diagnosis/ PAPILLOMA, metabolism/ `PERCHLORIC ACIDS, adverse effects/ PERCHLORIC ACIDS, diagnostic use/ POTASSIUM, stivers.' effects/ POTASSIUM, diagnostic utr/ "RADIOISOTOPE SCANNING/ RADIOISOTOPES, metabolism/ TECHNETIUM, metabolism POTASSIUM CHLORIDE ADVERSE EFFECTS 3433, Slde-effecU of potassium chloride In products with different dissolution rates Graffner C, et al. Acta Pharm Sere 119 28, Mar 71 ADULT/ CAPSULES/ COMPARATIVE STUDY/ DELAYED-ACTION PREPARATIONS/ FEMALE' GASTROINTESTINAL SYSTEM, drur eiiffi'/ III MW .MALE' MIDDLE AGE/ PLACEBOS/ `POTASSIUM CHLORIDE, adverse effecu/ TABLETS 3430. Fatal drug reactions among medical inpatients. Shapiro ,, T.-f~ - 4- --1_- fc~Z--^ t.1 d ^ S. et si. JAMA 2IA 487-72, ! Apr 7| ADMINISTRATION, ORAL/ AUKI)/ ASfAHAGlNA.NK, adverr.e effect*/ DRUG IIVpKRSKNSmviTY. dloltiay/ DRUG INCOMPATIBILITY/ DRUG THERAPY, adverse effects/ `DRUG THERAPY, mortality/ DRUGS, administration it dosage/ FEMALE/ hospitalization/ human/ HYPERKALEMIA, chemically Induced/ INFUSIONS, PARENTERAL, adverse effects/ INJECTIONS/ MALE/ MEDICATION ERRORS/ MIDDLE AGE/ POTASSIUM CHLORIDE, adverse effects/ PULMONARY EDEMA, chemically Induced POWDERS ADVERSE EFFECTS 3431. (lA>ng*tenn etudles following appllmtioo of various glove powders] Plelstlcker K, at al Chlrurg 41342-3, May 70 (Ger) ABDOMEN/ ADHESIONS, ehemlcelly induced/ ANIMAL EXPERIMENTS/ DERMATITIS. CONTACT, etiology/ ENGLISH ABSTRACT/ FOLLOW-UP STUDIES/ `GLOVES, SURGICAL/ `GRANULOMA, chemically Induced/ POWDERS, advert# effects/ RATS/ STARCH, adverse effects/ TALC, adverse effects PREDNISOLONE ADVERSE EFFECTS 3433. (A ease of glaucoma Induced by short-term systemic steroid therapy] Gl S. et al. Acta See Ophthalmol Jap 75:344*3, 30 Jan 7] (Jap) ADMINISTRATION, ORAL/ CASE REPORT/ CHILD/ ENGLISH ABSTRACT/ FEMALE/ GLAUCOMA, chemically induced/ HUMAN/ INTRAOCULAR PRESSURE/ PREDNISOLONE, administration A dosage/ `PREDNISOLONE, adverse effects 3433. A study of the effects ef corticosteroids on blood coagulation in rabbits. Mlshra KC, et ai. Indian J Med Bel 35:154-7, Mar 7! ANIMAL EXPERIMENTS/ BETAMETHASONE, adverse afreets/ `BLOOD COAGULATION DISORDERS, chemically induced/ CORTISONE, adverse effects/ `GLUCOCORTICOIDS, adverse effect*/ HYDROCORTISONE, adverse effect*/ PREDNISOLONE, adverse affecta/ RABBITS 3434. [Gray cataract caused by corticosteroids] Moiair L et al. Kill Meuatsbl Augenhcftlkd 158:578-84, Apr 71 fGer) `CATARACT, chemically induced/ CATARACT, diagnosis/ ENGLISH ABSTRACT/ FEMALE/ HUMAN/ MALE/ MIDDLE AGE/ PREDNISOLONE, adverse effects 8488. Management of chronic hepatitis. Lancet 1:1231-3, 12 Jun 71 AZATIIIOPRINE. therapeutic os#/ CHRONIC DISEASE/ FEMALE/ `HEPATITIS, drug therapy/ HEPATITIS. INFECTIOUS, complications/ HEPATITIS. TOXIC, complications/ HUMAN/ MALE/ PREDNISOLONE, adverse effects/ PREDNISOLONE, therapeutic use/ PREGNANCY 8484. (Cataract mused by corticosteroids] Moinlr L, et aL Orv HeUI 113:799-800, 4 Apr 71 (Haul CATARACT, ehcmleslly Induced/ FEMALE/ HUMAN/ MALE/ MIDDLE AGE/ PREDNISOLONE, adverse effects 3437. Advantages of prednisolone slearoylglycolatc in chronic steroid-dependent asthma. Pines A. Prarftiijeeer 2A4'5l9-4, Ap>r 71 ADOLESCENCE/ ADULT/ AGED/ `ASTHMA, drug therapy/ ItODY WEIGHT/ CHILD/ CHRONIC DISEASE/ CLINICAL RESEARCH/ COMPARATIVE STUDY/ FEMALE/ HUMAN/ MALE/ MIDDLE AGE' `PREDNISOLONE, administration it domxe/ PREDNISOLONE, adverse effects/ `STEARIC ACID, administration it dosage' STEARIC ACID, adverse effecu/ TABLETS, ENTERIC-COATED 3438. Side effects of long term steroid therapy la chronic lung disease. Kerrehljn KF ftr^ptrctlea 27,Syppi:*:;0-l, 1970 `ASTHMA, drug therapy/ CHILD/ CORTICOTROPIN, diagnostic use' ETHYLKSTRenOL, pharmacodynamic*/ `GROWTH, drug effecu/ GROWTH DISORDERS, chemically induced/ HUMAN/ A-251 DLX 5000 VINCHISTINK DRUGS AND CHEMICALS 31, EPILEPSY, vprrbrtwnln*! fluid/ "I.PILFPSY, ChcmlCAlly lndu?rd.' FlALM VJ HUMAN/ LEUKEMIA. drur Uaiai'y/ MAI.J,/ VINCIUSTINi:, advert? cCfaclH 4090. [Blast tell leukemia with bullous Uptons] DegnsR.clal Bull Soc Fr Dermatol Sypfullgr 76.270-1, 1D69 (Frc> BIOPSY/ BLISTER/ CASL REPORT/ HUMAN/ LEUKEMIA/ `LEUKEMIA, pathology/ MALE/ MIDDLE ACE/ POLYNEURITIS, chemically induced/ SKIN, pathology/ VINCRISTINE, ad verve offecu 4097. Combined actlnomycln D aod vincristine In the treatment of patients with cancer. Chine* RE, el al. Cancer 27:013*7, Mar 71 BREAST NEOPLASMS, drug therapy/ DACTINOMYCIN, administration & douge/ DACTINOMYCIN, adverse effects/ HUMAN/ LUNG NEOPLASMS, drug therapy/ MELANOMA, drug therapy/ NEOPLASMS, drug therapy/ SARCOMA, drug therapy/ VINCRISTINE, administration A dosage/ VINCniSTINE, adverse ef/ecU ' 4001, Vincristine, prednisone, end daunomyclo Jo acute leukemia of childhood. Vleltl TJ, et al. Cancer 17:602-7, Mar 7] ACUTE DISEASE/ ADOLESCENCE/ BLOOD CELL COUNT/ BONE MARROW CELLS, drug effect*/ CHILD/ COMPARATIVE STUDY/ DAUNOMYCIN, administration A deuce/ DAUNOMYC1N. advert* effect*/ "DAUNOMYCIN, therapeutic usc/ HUMAN/ LEUKEMIA, drug therapy/ LEUKEMIA. LYMPHOBLASTIC, drug therapy/ LEUKEMIA, MONOBLASTIC, drug therapy/ LEUKEMIA. / MYELODLASTIC, aru* therapy/ LEUKOCYTE COUNT/ PREDNISONE, administration k douge/ PREDNISONE, adverse effccu/ PREDNISONE, therapeutic use/ VINCRISTINE, admlnistratloo A dosage/ VINCRISTINE, adverse effects/ VINCRISTINE.'therapeutic use 4099. [Vlncrlatloc polyneuritis) Daun II, et al. Pertscht Neurol Piychlatr 39:151-65, Mar 71 (Gr) ADULT/ AGED/ BONE NEOPLASMS, drug therapy/ FEMALE/ HODGKIN'S DISEASE, drug therapy/ HUMAN/ LYMPHOSARCOMA, drug therapy/ MALE/ MIDDLE AGP,/ POLYNEURITIS, chemically induced/ SARCOMA. OSTEOGENIC, drug therapy/ VINCRISTINE, administration A dosage/ VINCRISTINE, adverse effects 4100. [Side effects of drugs. 4. Drug induced polyneuropathies and myopathies] Johanssoo B. Lakertldnlngta M&uppl IV:T7*f*. IS Dec 49 (BI ref.) (Swe> CHLOROQUINK. adverse effects/ CORTICOTROPIN, adverse effects/ GLUCOCORTICOIDS, adverse effect*/ HUMAN/ HYDRALAZINE, adverse affect*/ IS0NIA2ID, adverse effects/ MUSCULAR DISEASES, chemically induced/ NEURONS, AFFERENT, phytopathology/ NITROFURANS, \ adverse effects/ "PERIPHERAL NERVE DISEASES, chemically induced/ REVIEW/ THALIDOMIDE, adverse erfccts/ VINCRISTINE, adverse effecu 410L Neurological complications of systemic cancer. Posner JB, Med Clin North Am 59:425-40, May 71 (31 ref.) ADRENAL CORTEX HORMONES, adverse effeeta/ ADRENAL CORTEX HORMONES, therapeutic use/ ADULT/ AGED/ ASPARAGINASE, adverse effect*/ I1RAIN DISEASES, etiology/ BRAIN NEOPLASMS, complication*/ BRAIN NEOPLASMS, drug therapy/ BRAIN NEOPLASMS, radiotherapy/ CERVIX NEOPLASMS, complication*/ ELECTROENCEPHALOGRAPHY/ FEMALE/ GLUCOCORTICOIDS, therapeutic use/ HUMAN/ INFECTION, etiology/ MALE/ MELANOMA, complication*/ MENINGES/ METABOLIC DISEASES, etiology/ MIDDLE AGE/ MYELOGRAPHY/ NEOPLASM METASTASIS/ NEOPLASM METASTASIS, diagnosis/ "NEOPLASMS, complication*/ NEOPLASMS. NERVOUS TISSUE, complications/ NEOPLASMS. NERVOUS Tissue, diacnosh/ nervl compression, Ctioli>c>< '\,.ilVuUh .'-`i .'* Iku-,.4*ih, etiology/ NEUROLOGIC M S1' \7iONS' PERIPHERAL NERVE DISEASES, d mingy/ RADIATION INJURY/ BEVlm. SPINAL CORD COMPRESSION, etiology/ SPINAL CORD NEOPLASMS, complication*/ SPINAL CORD NEOPLASMS, drug therapy/ SPINAL A-302 2jjl / CORD NEOPLASMS, radiography/ VINCRISTINE, adverse effect* 4102. [ Experience with vincristine sulfate] lUrlwlch G, ct al. Med Writ 17:706 12. 24 Apr 71 <6er) ADULT/ AGED/ FEMALE/ "HODGKIN'S DISEASE, drug therapy/ HUMAN/ LEUKEMIA, drug therapy/ `LYMPHOMA, drug therapy/ MALE/ MIDDLE AGE/ POLYNEURITIS, chemically Induced/ SULFATES, therapeutic u*c/ VINCRISTINE, adverse effects/ "VINCRISTINE, therapeutic use 4103. (Effects of repetitive stimulations during neuropathies due to vincristine. Preliminary observations] Metre! S, et al. Rev Neurol (Paris) 123:275*9, Oct 70 (Pre) CniLD/ child, preschool/ ELECTROMYOGRAPHY/ FEMALE/ HUMAN/ INFANT/ MALE/ "NEPHROBLASTOMA, drug therapy/ "NEURAL CONDUCTION/ NEUROBLASTOMA, drug therapy/ NEUROMUSCULAR DISEASES, chemically Induced/ NEUROMUSCULAR DISEASES, phytopathology/ VINCRISTINE, administration 4 dotage/ VINCRISTINE, adverse effects VINYL COMPOUNDS ADVERSE EFFECTS 4104. (Effect of histamine on the main functions of the stomach in anacld gastritis in persona working with aromatic hydrocarbons] Bashirov AA. Ter Arkb 42:41*4, Doc 70 ' (Rot) ACHLORHYDRIA, chemically Induced/ ADULT/ AIR POLLUTION/ `ALKENES. adverse effects/ ENGLISH ABSTRACT/ ENVIRONMENTAL EXPOSURE/ FEMALE/' GASTRITIS, chemically Induced/ GASTRITIS, diagnosis/ "HISTAMINE, diagnostic use/ HUMAN/ MALE/ `OCCUPATIONAL DISEASES, diagnosis/ "STYRENES, adverse effecu/ VINYL COMPOUNDS, adverse effects POISONING 4]0S, [Characteristic of eloctroardtographtc changes in patients with chronic vinyl chloride poisoning) Kudriavtseva OF. Otg Tr Prof Zabol 14.54-4, Aug 70 *(Rus> ADULT/ AIR POLLUTION/ "ALKENES, poisoning/ "CHLORIDES, poisoning/ ELECTROCARDIOGRAPHY/ ENVIRONMENTAL EXPOSURE/ FEMALE/ HUMAN/ MALE/ MIDDLE ACE/ OCCUPATIONAL DISEASES, diagnosis/ VINYL COMPOUNDS, poisoning TOXICITY 4105. (Comparative aanlUry-tonlcologie characteristics of vlnylmethyladtpate and dlvlnyUdtpate plastleliers and standardisation of their content in water) Mlrenets NV. Gig Sanlt 35:00*9, Oct 70 <Rus) ADIPIC ACID, toxicity/ "ALKENES, toxicity/ ANIMAL EXPERIMENTS/ GUINEA PIGS/ MAXIMUM PERMISSIBLE EXPOSURE LEVEL/ MICE/ RABBITS/ RATS/ VINYL COMPOUNDS, toxicity/ "WATER POLLUTION/ WATER POLLUTION. CHEMICAL VIRAL VACCINES ADVERSE EFFECTS 4107, A method for detecting Newcastle disc*** vlru* of low virulence In poutiry vaccine*. Hirst RG, et al. Aust Vet J 47:119-21, Mar 71 ANIMAL EXPERIMENTS/ AUSTRALIA/ CHICK EMBRYO/ HEMAGGLUTINATION INHIBITION TESTS, veterinary/ HEMAGGLUTINATION TESTS, veterinary/ NEWCASTLE DISEASE, Immunology/ "NEWCASTLE DISEASE VIRUS, isolation 4 purification/ "POULTRY DISEASES. Immunology/ "VIRAL VACCINES, adverse effects/ VIRAL VACCINES, standard*/ VIRULENCE 41M. The development of a vaccine igilnat avian infectlou* iaryngotracheill*. IV, Immumtatloo of chicken* uh a m^dlflrd laryn'i-trachettl* vaccln* In the drl-Vf'g water, Sum berg Y, rial. Avisa Di* 15 413*7. Apr-Jun 71 ADMINISTRATION, ORAL' "CHICKENS/ UNA VIRUSES, Immunology/ EVALUATION STUDIES/ LARYNGITIS, immunology/ "LARYNGITIS, veterinary/ "POULTRY DISEASES, Immunology/ RESPIRATORY TRACT DISEASES, chemically induced/ OLI 5001 POLLEN DRUGS AND CHEMICALS POLLEN ADVERSE EFFECTS 12*7. (Chronic therapy resistant allergy and fitness (or military service?) Michel II. et at. Munch Med Worheunchr 113:1*9 70. 29 Jan 71 <C*r) ADULT/ ANTIGKI-LANTinODY REACTIONS/ ASTHMA, etiology/ DUST/ GERMANY, WEST/ HAY FEVER/ HUMAN/ `HYPERSENSITIVITY, familial A genetic/ HYPERSENSITIVITY, occurrence/ MALE/ `MILITARY PERSONNEL/ NUTS/ POLLEN, adverae effect* POLYETHYLENES adverse effects 3288. Inverted versus everted gastrointestinal anastomoses: the role of the everted mucosa In anastomotic breakdown. Hearn D. et at. Am Surf 36.728*30, Dec 70 ANIMAL EXPERIMENTS/ BACTERIA, growth it development/ BANDAGES, adverse effect*/ DOCS/ ILEUM, surgery/ INTESTINAL MUCOSA, microbiology/ `INTESTINAL MUCOSA, phytopathology/ `INTESTINE, SMALL, surgery/ MESENTERY, surgery/ PERITONITIS, etiology/ POLYETJJY'LENES. adverse effects/ `SURGICAL WOUND DEHISCENCE, etiology/ SURGICAL WOUND DEHISCENCE, phytopathology/ SURGICAL WOUND INFECTION, etiology/ SURGICAL WOUND INFECTION, phytopathology/ `SUTURE TECHNICS POLYMERS , ADVERSE EFFECTS S289. Hemolytlc*uromke-Jlke syndrome following polyearbozylste Interferon Induction. Treatment of Dawson's inclusion-body encephalitis. Leavitt TJ. et al. Am J Dis Child 121:43-7, Jan 71 ANEMIA. HEMOLYTIC, chemically Induced/ CHILD/ CHILD, PRESCHOOL/ FEMALE/ HUMAN/ `INTERFERON, adverse effecta/ `KIDNEY FAILURE. ACUTE, chemically induced/ MALE/ POLYMERS, adverae effect#/ PYRANS, adverae effects/ SUBACUTE SCLEROSING PANENCEPHALITIS, drug therapy/ `THROMBOPENIA, chemically Induced 3390. [Behavior of blood volume, duration of plaama expansion and aide effecta after parenteral administration of a gelatin polymer (m. w. 38,000)) Allegro G, et at. Arch Fatal CUn Med 44:359-44, Aug 70 (Its) ADULT/ AGED/ BLOOD COAGULATION, drug affects/ *BlOOI> VOLUME/ ELECTROCARDIOGRAPHY/ FEMALE/ GELATIN/ GELATIN, adverse effect*/ HUMAN/ INFUSIONS, PARENTERAL/ MALE/ MIDDLE AGE/ `PLASMA SUBSTITUTES/ PLASMA SUBSTITUTES, adverse effects/ POLYMERS/ POLYMERS, adverse effects/ PROTHROMBIN TIME ^ 3301. (Complications following reconstructive operations for oecluslve aorto-lliac lealons) Schneider K, et al. Langenbecks Arch Chlr 338:80.83, 1970 (Ger) AGE FACTORS/ AGED/ `ANEURYSM, etiology/ ANTICOAGULANTS, therapeutic ut#/ AORTA. ABDOMINAL, surgery/ ARTERIOSCLEROSIS, surgery/ `BLOOD VESSEL PROSTHESIS, adverse effects/ CHRONIC DISEASE/ `ENDARTERECTOMY, adverse effect*/ ENGLISH ABSTRACT/ FEMORAL ARTERY, surgery/ HEMATOMA, etlolugy/ HUMAN/ `ILIAC ARTERY, surgery/ MIDDLE AGE/ POLYMERS, adverse effects/ `POSTOPERATIVE COMPLICATIONS POISONING fit*. [Modern occupational diseases) Lechnlt V. Wlta Sled Wochrnschr 120.6204. 12 Sep 70 (Ger) AUSTRIA/ BEER, adverse effects/ DONE RESORPTION, chemically Induced/ COBALT, poisoning/ FARMER'S LUNG, chemically induced/ FARMER'S LUNG. Immunology/ FARMER'S LUNG, occurrence/ FINGERS, pathology/ HEART DISEASES, Chemically induced' HUMAN' OCCUPATIONAL DISEASES, ChemlCdliy Induci-O' OCCUPATIONAL DISEASES, occurrence/ PLASTICS, poisoning/ POISONING, occurrence/ POLYMERS, poisoning/ POLYVINYLS, poisoning/ PRECIPITIN'S, A-244 . i it 2_, analysis/ PULMONARY EDEMA, chemically Induced/ `TEClINGItOGY TOXICITY 3293. Trend* In preparation of new angiographic contrast media with special emphasis on polymerle derivative*. Hllal SK. Invest Radiol 9:488*72. Nov-Dee 70 AMMONIUM COMPOUNDS/ `ANGIOGRAPHY/ ANIMAL EXPERIMENTS/ CALCIUM/ CHEMISTRY/ `CONTRAST MEDIA, chem synthesis/ DOGS/ GELATIN/ GUINEA PIGS/ MAGNESIUM/ `POLYMERS/ POLYMERS, metabolism/ POLYMERS, toxicity 3394. Influence of cooking on foodstuffs. Lang K. World Rev Nutr Diet 12:246-317, 1970 (408 ref.) ANIMAL EXPERIMENTS/ ASCORBIC ACID/ BREAD/ CARCINOGENS/ CEREALS/ CHARCOAL/ CHOLESTEROL/ COFFEE/ COOKERY/ DIETARY FATS, metabolism/ DIETARY PROTEINS, metabolism/ FATS. ` toxicity/ FISHES/ `FOOD/ HEAT/ HUMAN/ MEAT/ MILK/ MONOSACCHARIDES/ NUCLEIC ACIDS/ NUTRITION/ NUTS/ OLIGOSACCHARIDES/ OXIDATION-REDUCTION/ POLYMERS, toxldty/ PROTEIN DENATURATION/ RATS/ REVIEW/ STARCH/ VITAMIN B COMPLEX/ VITAMINS POLYMYXIN ADVERSE EFFECTS 3393, Danger of polymyxin B inhalation, Marschko G, at aL Ann Intern Med 74:294*7, Feb 71 AEROSOLS/ BRONCHIECTASIS, complication*/ BRONCHITIS, complications/ `DRUG HYPERSENSITIVITY/ FEMALE/ HUMAN/ MALE/ MIDDLE AGE/ POLYMYXIN, administration A dosage/ `POLYMYXIN, adverse effocU/ PSEUDOMONAS * AERUGINOSA/ `PSEUDOMONAS INFECTIONS, drug therapy/ `RESPIRATORY INSUFFICIENCY, chemically Induced/ RESPIRATORY TRACT INFECTIONS, drug therapy 3294. Polymyxin Inhalation therapeutic hazard. Maraehko G, ot al. Ana Intern Med 74:144-3, Jan 71 `AKROSOltS, adverae effects/ FEMALE/ HUMAN/ ISOPROTERENOL, administration A dosage/ MALE/ MIDDLE AGE/ POLYMYXIN. Administration A dotage/ `POLYMYXIN, adverae effects/ PSEUDOMONAS INFECTIONS, drug therapy/ `RESPIRATORY INSUFFICIENCY, chemically Induced POLYSACCHARIDES. BACTERIAL TOXICITY 3397. [Toxldty of polyacchartde* from different polysaccharide containing fractions of alkali-forming enterobacteria] Raahba El, et al. Mikrobiol Eh 31:483-7, Scp*Oct 49 (Ukr) ANIMAL EXPERIMENTS/ ENGLISH ABSTRACT/ `ENTEROBACTEKIACKAE, pathogenicity/ MICE/ `POLYSACCHARIDES, BACTERIAL, toxldty POLYURETUANES TOXICITY 3293. Chemical structure of polyurethane foam. Woolrlch PF. J Orcup Med 12429, Dec 70 ClIEMIKTHY/ HUMAN/ `INDUSTRIAL MEDICINE/ NOMENCLATURE/ POLYURETHANES, toxicity/ `URETHANE, tox telly POLYVINYLPYRROLIDONE ADVERSE EFFECTS 3299. (UUrtstructure atydy of akin Infiltration by polyvinylpyrrolidone (aubitoaan)l L*uhg TK. et at Ann Dermatol SyphlUgr (Paris) 97:567-72. 1970 (Fr) BIOPSY/ FEMALE/ HUMAN/ LY50S0.ME5/ MALE/ MICROSCOPY. ELECTRON/ MIDDLE AGE/ `POLYVINYLPYRROLIDONE, adverse efleets/ POLYVINYLPYRROLIDONE, pharmacodynamic*/ `SKIN, drug effect*/ SKIN, pathology/ SKIN DISEASES, chemically Induced/ `SKIN DISEASES, pathology 3300. Uitraatruetural morphology iad histochemistry (add OLI 5002 DRUGS AND Cl iEPJJICALS 3! - '/*/ POTASSIUM pVtosphM**,') nf the Culiwieou* InfIRiatloii hy P0<yviu>lp>TpMttoiic` Tl.lvolot J, ct *1 Itr J Dr* tiiaiitl ji3f.Hl-!>, I*cp 70 *ACn> PHOSPHATASE, analysis/ BIOPSY/ FEMALE/ FlUllOHLARTN/ FIBROMA, enrymology/ -FIBROMA, i>ath'>|n(*v/ GRANULOMA, pathology/ HISTIOCYTES/ HlSTOCVTOClIKMISTaV/ HUMAN/ LYSOSOMES. tnrymoiocy/ MALL/ microscopy. electron/ middle age/ POLYVINYLPYRROLIDONE. adver* effecu/ POLYVINYLPYRROLIDONE, mrfabnlUiti/ SKIN, drug effect*/ SKIN, metabolism/ SKIN, pathology/ *SK<N DISEASES, chemically Induced POLYVINYLS ADVERSE EFFECTS M01. Occupational actooKleolyMv II, An industrial hygiene aludy. Cook \VA, el al. Arch Environ Health 22:74-82. Jan 71 bonk resorption, chemically induced/ BONE RESORPTION, etiology/ BONK RESORPTION, occurrence/ BONK RESORPTION, prevention 4 control/ CHLORIDES, adverse effects/ ENVIRONMENTAL EXPOSURE/ FEMALE/ HAND/ HEALTH surveys/ human/ INDUSTRIAL MEDICINE/ MALE/ OCCUPATIONAL DISEASES, chemically induced/ 'OCCUPATIONAL DISEASES, etiology/ OCCUPATIONAL DISEASES, occurrence/ OCCUPATIONAL DISEASES, prevention * control/ 'POLYVINYLS, adverse effects/ STATISTICS 2202. Occupational acroosteolysls. I. An epidemiological Study, ploman BD, et al. .-Arch F.urlron Health 22.61-72. Jan 71 ADULT/ 'ALKKNKS, adverse effect*/ HONE RESORPTION, chemically Induced/ DONE RESORPTION, etiology/ 'BONK RESORPTION, occurrence/ BONE RESORPTION, prevention 4 control/ -CHLORIDES, adverse effects/ FEMALE/ HAND/ HAND, radiography/ HEALTH SURVEYS/ HUMAN/ INDUSTRIAL MEDICINE/ MALE/ MIDDLE AGE/ OCCUPATIONAL DISEASES, chemically induced/ OCCUPATIONAL DISEASES, etiology/ `OCCUPATIONAL DISEASES, occurrence/ OCCUPATIONAL DISEASES, prevention ir control/ *POLYV!NYJ#S. adverse effects/ POPULATION SURVEILLANCE/ QUESTIONNAIRE/ RAYNAUD'S DISEASE, Complications/ STATISTICS 2202. Occupationalarrncsteolystt. 2. A clinical study, Dodson VN, ct al. Arch Environ Health 22.62-01. Jan 71 ADULT/ 'BONE RESORPTION, diagnosis/ BONE RESORPTION, prevention a control/ BONE RESORPTION, radiography/ CAIXHUM. analysis/ CATECHOLAMINES, urine/ 'CHLORIDES, adverse affects/ FECES, analysis/ FLUORINE, diagnostic use/ HAND, radiography/ HUMAN/ HYDROXYlNDOLEACmC ACID, urlna/ INDUSTRIAL MEDICINE/ MALE/ MIDDLE AGE/ 'OCCUPATIONAL DISEASES, diagnosis/ PHOSPHORUS, analysis/ PLETHYSMOGRAPHY/ 'POLYVINYLS, adverse effects/ RADIOISOTOPE SCANNING/ RAYNAUD'S DISEASE, complications/ 'RAYNAUD'S DISEASE, diagnosis 2204, IPatumoconlosis caused by Inhalation of polyvinylchloride] Srende B, ct al. Ore Unit 112.115 6, 10 Jan 71 (Hun) ADULT/ cm.ORIDK.S, adverse effort*/ DUST/ ENVIRONMENTAL EXPOSURE/ HUMAN/ MALE' "PNEUMOCONIOSIS, etiology/ 'POLYVINYLS, adverse effects POISONING 2205. Pneumoconiosis caused by the Inhalation of polyvinylchloride dust Szcnde B, et mL Med Lav 61:433 6. Aug-Sep 70 ADULT/ AI It POLLUTION/ ENVIRONMENTAL EXPOSURE/ HUMAN/ MALE/ 'PNEUMOCONIOSIS, etiology/ 'POLYVINYLS, poisoning 2304. (Modern occupational disease*] f-aehnit V Ulen Med Wochcnvrhf 1*0*20-5, 12 70 (Ger) AUSTRIA/ BEER, adverse effects/ HO\K RESORITJON. ehrr.uf.iliy Induced/ COBALT, poisoning/ FARMER'S* LUNG, chemically Induced/ FARMER'S LUNG, immunology/ FARMER'S LUNG, occurrence/ FINGERS. l*aUuli>r,y/ HEART HIS EASES, chemically hMlurmi/ HUMAN/ IKVUI*ATIONAL UISEASFS, rhriiiiiiiUy imlureil/ OCCUPATIONAL DISEASES, occurrence/ PLASTICS, pol&onlng/ POISONING, occurrence/ POLYMERS, poisoning/ POLYVINYI.fi. poisoning/ PRECIPITINS, analysts/ PULMONARY EDEMA, chemically Induced/ -TECHNOLOGY TOXICITY 2307. Poly<vlnylpyridlne oxides) In pneumoconiosis research. Holt PF. Br J Ind Med 26:72-7, Jan 71 (41 ref.) AEROSOLS/ ANIMAL EXPERIMENTS/ CELL MEMBRANE/ 'CYCLIC N-OXJDES, administration 4 dosage/ CYCLIC N-OXIDES, loalelly/ HUMAN/ INJF-CTlONS, INTltAPKRtTONEAL/ INJECTIONS, INTRAVENOUS/ INJECTIONS, SUBCUTANEOUS/ MACROPHAGES, drug effects/ MOLECULAR WEIGHT/ PERITONEUM, cytology/ PNEUMOCONIOSIS, drug therapy/ POLYSTYRENES, therapeutic use/ 'POLYVINYLS, administration 4 dosage/ POLYVINYLS, toxicity/ PULMONARY ALVEOU, cytology/ PUf*MONARY FIBROSIS, drug therapy/ `PYRIDINES, administration 4 dosage/ PYRIDINES, toxicity/ RATS/ REVIEW/ SILICA/ TISSUE CULTURE 2206. [Carboxyvinylpolymera In pharmaceutical technic. II] ParotU AG. Farmaco (Prat} 22:72142. Doe 70 <1U) ELECTROENCEPHALOGRAPHY/ EMULSIONS/ CELS/ HYDROGEN-ION CONCENTRATION/ IRRITANTS/ LUBRICATION/ OINTMENTS/ POLYVINYL' POLYVINYLS, toxicity/ SKIN TESTS/ SOLUBILITY/ SUSPENSIONS/ TABLETS/ TECHNOLOGY. PHARMACEUTICAL POTASSIUM ADVERSE EFFECTS 2202. Occupational dermatitis In five European dermatological department*. Malten KE, at aL Rernfsdermatosen 19:144, Feb 71 BALSAMS, adverse afreet*/ BENZOCAINE, adverse effeeta/ CHROMATES, adverse effecu/ CLINICAL RESEARCH/ COHALT, adverse effects/ EUROPE/ FEMAI E/ HAND DERMATOSES, occurrence/ HUMAN/ MALE/ NEOMYCIN, adverse effect*/ NICKEL, adverse effort*/ OCCUPATIONAL DERMATITIS, diagnosis/ *OCCUPAT10NAL DERMATITIS, occurrence/ POTASSIUM, adverse effects/ PROSPECTIVE STUDIES/ RUBBER, adverse effecu/ SKIN TESTS/ TARS, adverse effecU 2210. (Experimental base* for the use of acetylcholine in the treatment of arrhythmia* caused by potassium] Rainer! A* et al. Bel) 2oc 1U) Cardiol )0;77`90, IMS <lu) ACETYLCHOLINE, pharmacodynamic*/ 'ACETYLCHOLINE, pharmacodynamics/ ANIMAL EXPERIMENTS/ ARRHYTHMIA. Chemically Induced/ 'ARRHYTHMIA, chemically Induced/ DOGS/ ELECTROCARDIOGRAPHY/ ENGLISH ABSTRACT/ POTASSIUM, adverse effect*/ POTASSIUM, adverse effecu 2211. Toxic psychosis induced by Asthma-Dor, Huaaatn M& Can Med Assoc J 104:326. 20 Feb 71 ADOLESCENCE/ ASTHMA, drug therapy/ DRUG ABUSE/ HUMAN-' MALE/ NITRATES, adverse effect*/ PLANT EXTRACTS, adverse effect*/ POTASSIUM, adverse effect*/ rSYCHOSES, TOXIC/ STRAMONIUM, adverse effecu 2212. (On akin morbidity eau*ed by eement In construction worker* and cement worker*] PetrmzclU* V. et al. O Hal Dermatol 44:485-7, Sep 9 (Ita) CHROMATES, adverse effect*/ -DERMATITIS, CONTACT, chemically Induced/ HUMAN/ OCCUPATIONAL DERMATITIS, chemically Induced/ POTASSIUM, adverse affect* 22)2. Patch testing with potassium diehromate in different vehicle* Fknr E. et al. C Ital Dermatol 44:467-9. Sep 9 CHROMA* ES. adverse effect*' -DERMATITIS, CONTACT/ POTASSIUM, adverse effect*/ SKIN TESTS/ 'VEHICLES, pharmacodynamics 2214. Electron microscope observation* On form changes in A-245 OLI 5003 n roi.VMYXlN DRUGS AND CHEMICALS INFANT. NKWHOHN/ KIDNEY, tlni* rffrctu/ K1DNKY IXSKASKN. rht-mlrally Induced/ neuromuscular hinkaslk, chemically Induced/ POLYMYXIN, atlmlnltiirullon 4 dosage/ POLYMYXIN, adverv* efforts/ POLYMYXIN, metAtmllMm/ POLYMYXIN, pharmacodynamic*/ `POLYMYXIN, therapeutic use/ `PSEUDOMONAS INFECTIONS, drug therapy/ REVIEW/ SULFATES/ `URINARY tract infections, druf therapy POLYNUCLEOTIDES TOXICITY 3S14. Pharmacology of polyrlbolnosinlc: polyrlbocytldyllc add, a new antiviral and antitumor agent. Adamson RII, et a). Antlmlcrob Agent* Chemotfcer 9:148*52,1969 ANIMAL EXPERIMENTS/ `ANTINEOPLASTIC AGENTS, therapeutic use/ "ANTIVIRAL AGENTS, pharmacodynamic*/ CYTOSINE/ EMBRYO, drug effect*/ MICE/ MONKEYS/ NEOPLASMS, EXPERIMENTAL, drug therapy/ POLYNUCLEOTIDES, ehem aynthcslt/ `POLYNUCLEOTIDE, therapeutic use/ POLYNUCLEOTIDES, toatclty/ , PREGNANCY/ RABIUT5/ RATS/ RNA. them synthesis/ RNA. pharmacodynamics/ RNA, therapeutic use/ RNA, toatclty ISIS. Toatclty of poly I; poly C for rabbit eye*- Oatler HB, et aL Nature (Load) 228:363-4. 24 Oct 70 ANIMAL EXPERIMENTS/ AQUEOUS HUMOR, drug effect*/ `CATARACT, Chemically induced/ `CYTOSINE NUCLEOTIDES, toatclty/ DISEASE MODELS, ANIMAL/ HERPESVIRUS INFECTIONS, drug therapy/ INTERFERON, biosynthesis/ KERATOCONJUNCTIVITIS, drug therapy/ LENS, CRYSTALLINE, drug effect*/ POLYNUCLEOTIDES, therapeutic use/ POLYNUCLEOTIDES, toalelty/ RABBITS 1514. Morphological ehange* in chick cerebellum induced by poly Lpoly C- Young PA. ct Nature (Londt 228:1191*2, 29 Dec 70 ANIMAL EXPERIMENTS/ `ANTIVIRAL AGENTS, toaldty/ CAPILLARY FRAGILITY, drug effects/ `CEREBELLAR ATAXIA, chemically induced/. CEREBELLUM, blood supply/ CEREBELLUM, drug effect#/ CHICKENS/ INTERFERON, biosynthesis/ MICROSCOPY. ELECTRON/ POLYNUCLEOTIDES, toaldty POLYSACCHARIDES TOXICITY till. Fractionation and purification of the polysaccharides with marked antitumor activity, especially lentlnao. from Lenllnus edodea (Berk.) Slog, (an edible mushroom). Chlhara G, et el. Cancer Res 30:2774-41. Nov 70 ANIMAL EXPERIMENTS/ CHROMATOGRAPHY, DEAR-CELLULOSE/ ELECTROPHORESIS/ HYDROGEN-ION CONCENTRATION/ MICE/ `MUSHROOMS/ OPTICAL ROTATORY DISPERSION/ POLYSACCHARIDES, isolation A purification/ POLYSACCHARIDES* therapeutic u*e/ POLYSACCHARIDES, tonicity/ `SARCOMA ISO. CROCKER, d*ug therapy/ TISSUE EXTRACTS/ ULTRACENTRIFUGATION POLYSACCHARIDES* BACTERIAL ADVERSE EFFECTS 35X1. Metabolic and thermal responae* to Ptromen in man. Davidson MB, et al. J CUn Endocrinol Metab 33:179.87. Feb 7! ADULT/ `BLOOD SUGAR/ BODY TEMPERATURE, drug effect*/ CLINICAL RESEARCH/ `FATTY ACIDS. NONESTERIFIED. blood/ GLUCOSE, pharmacodynamics/ *GLYC>:niN. blood/ HEADACHE, chemically Induced/ HUMAN/ `INSULIN, blood/ LIPIDS. metabolism/ MALE/ POLYSACCHARIDES. BACTERIAL adverse effect*/ `POLYSACCHARIDES, BACTERIAL pharmacodynamics/ PSEUDOMONAS/ RESKRF1NE. ph.nrmaeodynamics/ SltlVKKINU SOMATOTROPIN, blood/ SOMATOTROPIN, accretion 3519. (Aotl-tumor activity and Bide reaction of bacterial component) Umetawi I. iap J Antlblot 33.287-97, Jun 70 (J*p> ANIMAL EXPERIMENTS/ ANTIBIOTICS, A-252 4 2* -x V anti neoplastic, therapeutic u*e/ body TEMPERATURE, drug effects/ CAHC1NOMA, EHRLICH TUMOR, drug therapy/ `ESCHERICHIA COM. analysis/ LEUKOCYTE COUNT/ LEUKOCYTES, drug effect*/ LlPOPOLYSACCllARIDES, adverse effects/ MPOFOLYSACCHARIDES, therapeutic use/ MICE/ `POLYSACCHARIDES. BACTERIAL adverse etfccl*/ `POLYSACCHARIDES. BACTERIAL, therapeutic use/ PSEUDOMONAS AERUGINOSA, aftalyxis/ RABBITS/ RETICULOENDOTHELIAL SYSTEM, drug effect*/ `SARCOMA 180, CROCKER, drug therapy/ `STAPHYLOCOCCUS, analysis/ STREPTOCOCCUS PYOGENES, analysis POLYSTYRENES ADVERSE EFFECTS 3535. An evaluation of polyelectrolyte complexes as biomedical materials. Marahaii Dw, et at. 3 Btemcd Mater Res 4:357-0*. Sep 70 ANIMAL EXPERIMENTS/ BIODEGRADATION/ BIOMECHANICS/ EQUIPMENT AND SUPPLIES/ `MEMBRANES, ARTIFICIAL/ POLYMERS, adverse effecU/ POLYSTYRENES, adverse effect*/ POLYVINYLS, adveree ef/eeU/ `PROSTHESIS. Uodards/ RABBITS/ RATS/ STERILIZATION/ THROMBOSIS, chemically induced POLYTHIAZIDE adverse effect* 3521. Praaoato hydrochloride (CP-12,299-1), an oral aotl-hypertenslve agent: preliminary ctlniatl ebeervatlons In ambulatory patient*. Cohen BM. J CUn Pharmacol 10:408-17, Nov-Dee 70 ADOLESCENCE/ ADULT/ AGED/ AMBULATORY CARE/ ANTIHYPERTENSIVE AGENTS, adverse effects/ ANTIHYPERTENSIVE AGENTS, therapeutic use/ BLOOD PRESSURE, drug effects/ - CLINICAL RESEARCH/ COMPARATIVE STUDY/ ELECTROCARDIOGRAPHY/ FEMALE/ HUMAN/ HYPERTENSION, blood/ MALE/ MIDDLE AGE/ PIPKRA21NES. adverse effect*/ `PIPERAZINES, therapeutic use/ PLACEBOS/ POLYTfllAZlDE, adverse effects/ POLYTIIIAZIDE, therapeutic use/ QUINAZOLINES. adverse effect*/ QUINAZOLINES, therapeutic use POLYURETHANES AOVtRII EFFECT* *522. [Use of polyurethanes In the building tndusty. Pathological surds and their prevention) Juuieo G, et nl. Aren Mai Prof 31*44, Jao-Feb 70 (Frel ENVIRONMENTAL EXPOSURE/ FRANCE/ HUMAN/ INSURANCE, HEALTH/ LEGISLATION/ `OCCUPATIONAL DISEASES, Chemically induced/ OCCUPATIONAL DISEASES, -prevention A control/ POLYURETHANES, adverse effect*/ SKIN MANIFESTATIONS POLYVINYLPYRROLIDONE ADVERSE EFFECTS 3529. [Thesaurismosis due to polyvinyl pyrroUdone resembling Inflammatory tumor of the big epiploon] Coulaaud C, et al, Prease Med 73:1839-41. 10 Oct 70 (Pr> ADULT/ DIAGNOSIS, DIFFERENTIAL/ FEMALE/ `GRANULOMA, chemlially Induced/ GRANULOMA, pathology/ HUMAN/ MALE/ METABOLIC DISEASES/ MIDDLE AGE/ OMENTUM, pathology/ OMENTUM, furgery/ PERITONEAL DISEASES, chemically induced/ PERITONEAL DISEASES, pathology/ PERITONEAL DISEASES, surgery/ PERITONEAL NEOPLASMS, diagnosis/ POLYVINYLPYRROLIDONE, adverse effect* POLYVINYLS ADVERSE EFFECTS 3524. [Hazard* to the akin In (he plasties industry) Wetehardi H. UtrufaderitiaUHva IV.25-34, Feb 70 (Gtr> ACNE, chemically Induced/ ACRYLIC RESIN*, adverse effect*/ ALANINE AMINOTRANSFERASE, blood/ ASPARTATE AMINOTRANSFERASE, blood/ BILIRUBIN, Mood/ BONE RESORPTION, etiology/ OLI 5004 iioy/4 ( ii' iiiii .</ /\/>' h.ii r. Vdl. /i, J%'J with DM?: CI IO.\c nr C11 *11' 1 li >1 i t-mhI ,(| ,i), ,| .'! !ivihit*y- plnpylm, ie:i|dlll ii` ill III I A iii'i'l J I V' i i I -11 \ , b i,\ ypl,*| I I t V*.- Iiiih', ] ). `J lii'lc \v:r> mi < t iil''iu ' [' I| Ii '-In i- n( :ilh inn i cnp.llll UL ill'll I ( A'-;ii i I \ I .till I I t \ 1 11 i *i1 , III in I In- liltin' i if tlli"'i' lltiim.tN. 11, Inmi'liT. iVil i ih'li'i I'-I hi till' linin' nf ill*, iujcrlcd s.e. with Ulb'.UIIUI, .S'-n11111,iin ini', iinil 5-;illyl'l-- cysteine. Uiii-i trend'd wiili ClliiClJCl iiHn evented 1. Men capturic acids apparently arise iiv tlic reaction of nllyl compels. or their arlive derivs, witli I'.ltllalliiniii'. BfJJX 110574p Metabolites of octoclothipinc eliminated in human and rat urine. ilueiM.eimn, Milena, Svatelt, li.; Mclysnvu, Jirina (Res. Inst, l'liann. Uiochein., I*ra:;ue, Czech.). Jiiochan. J, 1969, 111(2), 330-42 (line), l our metabolites and unchanged octodothcpine were extd. with didiloroctliaiie from tlic urine of humans given octoclotliepine. These substances were isolated end purified by column and thin-layer chromatog. By chro matographic, spcctrophotomclric, and polarographic anal., unchanged octoclotliepine and 3 of the mclalKihtes were identified (noroctoclothepine, norocioelothcpine 5-oxide, and octoclothe- pinc 5-oxide). The presence of glucuronides in human urine was shown. The same metabolites and unchanged octoclotliepine were also found in rat urine by chromatog. RCFG 110575q Mechanism by which leucine and arginine stimulate insulin release in vitro- Milner, U. 1). G. (Univ. West Indies, Kingston, Jamaica). Murium. Bto/dtys. ,1 i/,i 1909, 102(1), 15-1--G (Eng). Basal insulin release lit young rabbit pancreas slices itt vitro was higher in the presence of leucine (limit/) than of arginine (5mM) (in the absence of glucose). Glucagon (5 pg./ml.), theophylline (lm.l/), dibulyryl cyclic AMP (ltnil/), or L-argininc (StnM) stimulated insulin release in the presence of leucine but not in the presence of arginine. Arginine-stimulated basal insulin release perhaps works by releasing glucagon from the o-cells. The mechanism of the leucuic-imluccd stimulation is different, probably via the adenyl cyclase system- BSJX 110576r Cytochemica! study of the distribution and content of nucleoproteins and of some functional groups of proteins in iso lated formations of the central nervous system following foreign protein injection. Tuntanyan, E. L- (Erevan. Med. Inst., Erevan, USSR). Biol. Xh. Arm. 1969, 22(5). 97-8 (Russ). Cytoplasm of various parts of rabbit central nervous system (including intervertebral ganglia, nuclei of the XII cranial nerve, and skin motor area of brain cortex) displayed higher filxmuelco- protcin content in animals treated with repented t.v, injection of normal horse serum. The peak effect was observed on the 4th day after the last injection. N i changes wcie seen in content and distribution of prneiu SII groups. X. Jasinezuk 110577s DNA synthesis in mouse embryonic fibroblast-like cells in vitro, stimulated by various factors. Vasil'ev, Yu. M.; Gel'fand, 1. M.; Gershtein, V. I,; Fetisova, E. K. (Mosk. Gos. Univ., Moscow, USSR). DM, Akad. Maui 555'K 1969, 187(4), 913-15(Cytol] (Russ). Autoradiography was used to follow the DXA synthesis in single-layer cultures of mouse embryo fibro blast-like cells in lactaibumin hydrolyzate and ox serum media in the presence of thymidine-*// added at various periods of culture age. The index of *11 inclusion was increased by addn- of tes ticular or bacterial hyalurmiidascs, It.N'j'o. and digitouiii. The rise of *H intake was the result of stimulation of the entry of the cells into the S-phase of development. G. M. Kosolapoff 1105781 Effect of pregnancy and oral contraceptives on glu cose and insulin metabolism. Taskmrn, Marja K. Dundertm 1969, 85(11), 67(5-83 (Finnish). A review. The effect of both pregnancy and oral contraceptives is diabetogenous, and they may cause deterioration of glucose tolerance in healthy women. The organism tends to compensate this by enhanced insulin secretion, which leads to hyperinsulinism. 43 references. I. G. Zewi 110579U Effect of pyridoxal 5'-phosphate on the strength of skin In vitro, llarkursx, Robert 1). (Univ. Cnll. London, Lon don, Engl.). I'.y/mriniliii 1900, p.KKi), Inis P (Kni:). Trcal- ini'iil with lllni.l/ |iyrii)o\:d 5' |iliif |.li,iI(1) in vilto ti-dtu'i-d die Mri'tif'.lli of r,it tad skill piui-n -.'.ivrlv with tnnr nf in, nlMlinn. The refill, was reversible, with slrcncih returning when the skin rings were placed in buffered s-ilmr. Pyridoxamine or pyrl- doxine at lOm.l/ had no comparable efTect. The effect of I was reduced ill the presence of lysine. I'retreatment of tile skin with KaBili, followed by washing in siilntr buffer, largely inhibited the effect of I. I'rrtrcaiuii-nr with Nll-OIf also mhibited the effect of 1. Treatment with XI l-O] i after I prevented the re covery of strength on subsequent transfer to the saline buffer; H.XXD- had a similar effect. The cuVet of I on skin strenctn is apparently hr1', ni d hi: -1; a... cm thine I .i-ages formed betnern an aiii. inde mid .'innio t-rmio. J JX l!0580n Diabetogenic etiect of t-asparaginase. Khan, Amamdlah; Adarln, Mitsuo; Hill, Joseph M.n (Vlasiian (Wad- ley Inst. c,f Mol, Med., Dallas, Te\.l. J. Clut. Endocrinol. Mttab. 1969, 29(10), 1373-d (Eng). The effects of Escbrrirhia ooli L-asparaginasc (500-50.000 I.U./kg., i.v,), which has been used to induce remission of human anile lymphatic and myelog enous leukemias via depletion of an amino avid essential (or some neoplastic ceils, on rabbit blood and urinary glucose levels were studied. A dose of PISK) J*U, i.-aspnragiuase/ky. I'lyeeiui.t and glyeo.-.uiia in most of the miimuls; II, do e icliiih indue, d hypel'glv, fluiu when I'lVeu lo luhliils leieiviui; 111,1100 |.U. l.-as|iiiragmnse/kg. o, di.iheiogeiiic responses, but these effects were in* ihiys) and were not assoed. with any histological , pancreatic islets, except in 1 rabbit which showed , tiun. 11 OSS J p Effect of Bidrin on the metabolism of ponents by the bovine. Lowrcy, R. Sd Bowman, Knox, F. E. (Coastal Plain Exp. Sta., Agr. Res. d Ga.). J. Dairy Set. 1969, 52(9), 1409-3 (Jim; averaging 400 kg, in wt, were used in a switchback the cflcct of spiking corn silage with 15.7 ppm. lo body wt.) of the pesticide Bidrin |3-(dimethoxyph' A\A'-dimcthyl-cij-crotonamide| on blood cholinesi, ibility of dietary components, utilization of X, and r; tat ion. llidrin residues were not found either in th the feces of animats ingesting Bidrin. Azodrin, a . Bidrin, wus not present in the feces of treated anim aged 0.430 ppm. in the urine. Based on urine vc, tented 1.5% of the ingested Bidrin. Blood cholm. depressed to 30% of pretreatnu-nt values by the end . cxptl. period, whereas activity of steers (cd tintrc.u. uiiaffrvted. In the metabolism trial cntidiicieil du 14 days of the 42-day period Bidrin had no effect >,ibility of dietary components (dry matter, crude p. ext-, crude fiber, N-frec ext., and gross energy), tl; of X, or rumen fermentation. 116582q Eflect of a second dose of cadmium salt', permeability in the tat testis. Clegg, E. J.; Carr, , M- (Ulliv. Sheffield, Sheffield, Engl.). J. Endocm: (2), 205-8 (Eng). Two doses of CdCli were give intervals varying from 7G to 194 days. After the sec, blood vessels in the testis and initial segment of th, showed increased permeability, as demonstrated by > In the testis, leaking vessels were usually found in interstitial cells were abundant. 110583r Acid-base and electrolyte changes indue isotonic saline infusion in the nephreetomized dog. ' Barry J.; Makoff, Dwight L.; Maxwell, Morton oughi, Michael (Cedars-Smai Med. Res. Inst., 1. Calif.). J. Lab. Clin. Mid. 1969, 74(3), 427-35 mechanism and extent of "dilution acidosis" by acr of isotonic saline was studied in iiephrectomircd dog. of 50,75, and 100 ml./kg. of body wt. (BW) (Group over a 30-min. period resulted in extracellular fluid, 24.4 1.7%, 28.8 * 2.2%, and 33.9 5.5%, resp. kept const. Body spaces were measured isotopicalb cellular H+ activity by 5,5-dimethy!-2,4-oxa*olidn The extracellular bicarbonate concn. decreased only mcq./l. and --2.5 0.4 meq./l- in Groups 1 and 2 a 1.0 in Group 3. The total amt. of extracellular bii creased +0.6 rfc 0.2 ncq./kg. of BW, 4-0.8 0.2 i BW, and +1.5 + 0.4 mcq./kg. of BW in each group, comitantly, the total nint. of extracellular fluid K ini' 0.0 ineq./kg. of BW, +0.5 0.1 mcq./kg. of BW ds 0.1 meq./fcg, of BW, resp., while there was no extracellular K concn. It was suggested that the exti Carbonate and K eonens. were defended by shifts nf I (or bicarbonate out of cells), in conjunction with a out of cells. Despite the presumed H* (or bicarl there were no net changes of H* activity- The theory of extracellular "dilution acidosis" is valid bir magnitude and little din. significance when expansion slow. Cellular buffering minimizes the extraecllu.' and the shift of K out of cells prevents hypokalemia 110584s Effect nf erythropoietin on bone mnrr, levulinlc neiil sylilhot,iso anil heme syitlhetiiite. Sylvia S.; Smdbeo, G. Ami (Vclciaiis Admin- limp City. Ohl:,.). ./. Lab. Clin. Med, 1969 , 74(3), II An in vitro culture method has been adapted for : marrow and has permitted measurement of the effect poietm on A-amiiiolcvulinie acid synthetase and henn activities in fj irrmv cells. In this system, erythr haiieed A-nmiimlfvuh'iic acid syndic lace activity, was detectable as early as 6 hrs- after contact with c, v The max. enzyme activity observed was 200% gr.a ulated than in control cultures. Studies with inhd ttin synthesis surgested that erythr,,pn,*'fn inr>t tin-*oi lue enzyme. No stimuiuiory cifcct bj . nil heme synthetase activity was obei-rnd. 110585t Action of adenosine triphosphate on '.h spontaneous electrical activity of the dog cerebral cci Gian; Amgoni, Elena; Ferrara, A.; Mascheip., I'harmacol., Univ. Pavia, Pavia, Italy). J. /'!"'1 5>S(0), 1161-3 (Eng). The repeated suppression of lion and the circulation of the brain in thr dog unit,-. prcssion or a silence of elec, activity of the curt,,, cortical centers. The recovery of respiratory and OLI 5005