Document OE49KmqaR7Gj18OjZwqVZrBxX

MANUFACTURING CHEMISTS ASSOCIATION 1825 CONNECTICUT AVENUE, N. W WASHINGTON, D. C. 20009 (202) 483-6126 July 24, 1974 To: Technical Task Group on Vinyl Chloride Research Subject: MCA Submissions for OSHA Hearing Record Gentlemen: In response to a number of requests made to industry witnesses at the vinyl chloride hearing, MCA has submitted for the hearing record, the documents itemized in the enclosed letter to OSHA. Exhibit No. 10, the IBT status report presented by Dr. Torkelson at the New York Academy of Sciences meeting, is enclosed herewith. It will be published in the Annals of NYAS for that meeting. Sincerely, KDJ/mb Enclosures Kenneth D. Johnson, Ph.D. Secretary Technical Task Force on Vinyl Chloride Research UCC 000879 INTERIM RESU] V.S OF EXPOSURE OF RATS, HAMSTERS AND MICE TO VINYL CHLORIDE M. L. J. W. D. E. and J. C. Kop)ingcr,t Ph. D, / Goode, Ph..D 1 Gordon, D,.V .M. , Ph. D. Calandra, M D., Ph.D. Industrial. Bio-Test Laboratories, Inc. Northbrook, Illinois The following data are partial results of a study in progress at the Industrial Bio-Test Laboratories, Inc. The studies ar< being coordinated for sponsoring companies by the Manufacture Chemists Association. The data are very incomplete but becam : of their significance were first presented to EPA, NIOSH and OSHA on April It, 1974. In this study which was designed to complement Maltoni's studies, 100 rats, hamsters and mice of each sex (600 total per exposure group) are being exposed to either 0, 2500, 200 or 50 ppm vinyl chloride vapor 7 hours per day 5 days per week. Mice will be exposed for 9 months and kept for an additional 9 months. Rats and hamsters will bo exposed for 12 months and kept for an additional 12 months. The rats are COBS Charles River; mice are CDI Swiss Charles River; and the hamsters are Golden Syrian from the same source. Food is removed during exposure, water is present and no bedding is used at any time. Moribund and dead animals (when possible) receive gross autopsies and are photographed. The major organs of all animals are fixed for histological examination. Only the tissues from a few animals have been examined so far. The table shows the results to date (about 8 months exposure). UCC 000880 Note that no direct numerical compnri.r.ons can be made with the control groups ns they have "ot been seloc.'Led in the same way. Only mice with tumor:; have been examined in the exposure groups. No tumors have been observed grossly as yet in any of the control mice. In addition to the tumors in mice a few tumors have been observed in rats and hamsters but because of autolysis the diagnosis at this time must be considered tentative. At this time it appears that angiosarcomas may have been observed in one male hamster and one male rat exposed to 2500 ppm and in one female rat exposed to 200 ppm. No tumors have been observed in rats or hamsters exposed to 50 ppm but one male control was found to have a dermal fibroma. These tentative data need to be confirmed and will be reported in detail when the study is completed. n ucc 000881 ucc 000882 EXPOSURE GROUP CONTROL 50 PPM*** 200 ppm** 2500 ppm** INTERIM SUW1ARY OF TUMORS IN MICE EXPOSED TO VINYL CHLORIDE FOR EIGHT MONTHS NUMBER OF MORTALITIES WITH NEOPLASMS TOTAL MALE FEMALE 0 (7) (2) ALVEOLOGENIC ADENOMAS, _ LUNG 0 Location and Type of Tumor ANGIOSARCOMA, LIVER ADENO SQUAMOUS CARCINOMA, MAMMARY 00 4 13 2 2 2 15 3 12 30 6 24 12 23 11 28 3 6 MAMMARY, WITH METASTASIS TO LUNGS 0 2 1 1 * 7 MALE AND 2 FEMALES CONTROL MICE HAVE BEEN EXAMINED HISTOLOGICALLY. NONE HAD TUMORS IN LIVER, KIDNEYS, HEARTS OR LUNGSi ** Only mice with tumors haye been examined histogogically. Mice were exposed 7 hours/day, 5 days/week. Preliminary Findings from MCA Administered Study at Industrial Bio-Test laboratory April, 1974