Document OE431Q9drw2Q97BONrke5aYEv

F-- ....................... .... ................... MA- M PERSONAL AND CONFIDENTIAL TO: W. A. BOWER FROM: Y. L. POWER, M.D. September 20, 1978 y *-> A review of the medical records of eleven operators and eighteen laboratorians who have had long-term exposure to C-8 was undertaken. As you would anticipate, a great variety of illnesses and physical findings were found; but I do not believe any of these are caused by exposure to C-8. Some of the illnesses found are two heart attacks and five employees with high blood pressure. One questionable case of skin cancer was found during an employee's physical examination in 1976. No further mention of this possible tumor could be found. Minor elevations of many blood tests did occur in larger-than-anticipated numbers and are listed separately. With the exception of one person, all of the elevations were borderline and not indicative of disease. One of the liver function tests (SGOT) is most frequently elevated in the operator group. However, no liver diseases were found. Many of the laboratorians also work with Perclene, which is a known hepatatoxin. In conclusion, I could find no unusual health prob lems occurring in the group of people studied, with the exception of borderline elevation of liver function tests. Since it has been previously determined that C-8 is an hepatatoxin, it is possible that C-8 may be causing very minimal, and certainly not clinically apparent, toxic effects to the liver. Because the total number of records reviewed is small (31), I do not believe any findings of this study are statistically valid. P YLP:vf AJP001418 EID080233 00013S PERSONAL AND CONFIDENTIAL LAB TEST % OPERATORS WITH ABNORMAL TESTS ** % LABORATORIANS WITH ABNORMAL TESTS ANTICIPATED LEVEL FROM STUDY 1976 (% WITH ABN0FMAL TESTS) * SGOT * Alkaline Phosphatase Albumin Uric Acid Cholesteral BUN Glucose Calcium Total Protein * Bilirubin LDH 60 30 10 10 30 30 10 10 10 0 0 11.2 16.7 16.7 5.6 0 11.2 27.8 0 0 11.2 11.2 14.21 6.84 1.58 4.21 1.05 3.68 1.58 0 0 1.05 1.58 * Liver function tests. ** Only 10 operators had liver function test done. YLP:vf 9/20/78 000136 EID080234 oo*o VO