Document O61Kzky64q7eNqwzY8DLEKQ1
P OCT-16-1996 10!33
UISTfi SFTY HLTH t ENVIRON
UNITED STATES ENVIRONMENTAL PROTECTION AGENCY ' WASHINGTON, D.C, 20460
P.001^010
SEP 2 5 IS96
OFFICE OP FFEVSWTIQN. PffsncOESANO
TOXIC SUBSTANCES
To: US SIDS Conltact Points
Rc: Selection of Chemicals for Sponsorship in the SIDS Program
Dear Colleague:
The OECD has requested that countries identify chemicals for sponsorship in Phase 6 of the OECD SIDS program (see attached letter from the OECD). The US has committed to sponsoring 25% of the SIDS chemicals as its "share of the burden.'* Approximately 50 chemicals are selected for each "phase" of the program. Consequently, the US should sponsor at least 13 Phase 6 chemicals to show our continued support and involvement in the program. However, at this time the US is behind in its sponsorship commitment by 9 chemicals. Therefore, I propose that a total of 15 chemicals be nominated for sponsorship in Phase 6 for the purpose of reducing the backlog (note that the OECD's letter includes a set of 16 chemicals selected by Japan for Phase 6). The OECD has requested that nominations for Phase 6 chemicals be submitted to the OECD by December l, 1996. Further, the OECD recommends that countries select a mix of weli-studied and data-poor chemicals to help assure that some SIDS testing will be done.
As noted in the OECD's letter, the candidate list from which to select chemicals for sponsorship is now the 19J5 OECD List of High Production Volume (HPV) Chemicals. This list combines the European Union's HPV list and the updated national HPV submissions from nonU OECD Member countries. It currently contains about 2500 chemicals, including all US HPV chemicals (based on JUR reporting). As l have discussed with CM.A EPA has decided to take a more active role in recommending candidate chemicals for companies to consider sponsoring under the SIDS program, As a first step in taking that more active role, the enclosed list identities a large number of chemicals which, for the reasons indicated, have been recommended for consideration by US companies,
Pot-h" brand lax transmittal memo 7671
Dave
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SL 110125
OCT-16-1996 10!33
UISTfl SFTY HLTH i ENUIRQN
P.002/010
While the 0CD has set a December 1 deadline, I would like to have a good idea of
possible US candidates in tyae-fur-HR OEtU s Jomt Meeting and Existing Chemicals Steering Group meetings schedule^for November 5*8. LwriT have an opportunity during the meetings to discuss candidates with outer cumurlSS'aiid toresolve any issues which might arise.
Enclosure
Sincerely,
cllu. %
Charles M. Auer Director Chemical Control Division (7405) USEPA 401 M Street. S.W. Washington, D.C. 20460
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UISTA SFTY H-TH & ENUIRON
P. 003/010
Potential Candidates for US Sponsorship in SIDS
A) The following three candidates are High Production Volume chemicals that are involved in a TSCA 41, testing program but are not already sponsored in the SIDS program.
1) Phenylenediamine. para* 2) Amyl acetate, n3) Bisphenol A diglycidyl ether
CAS No. 106-50-3 CAS No. 628-63-7 CAS No. 1675-54-3
The following: 13 candidates were the subject of TSCA testing requirements under 4 which have been completed. The cases are currently in OPPT's Risk Management One (RMl) queue.'t
I) Trichl<jroethane, 1.1,1-
CAS No: 71-55-6
2) Vinyl fluoride
CAS No. 75-02-5
3) Vinylidene flouride
CAS No. 75-38-7
4) TetrachJoroethane, 1,1,2,2-
CAS No. 79-34-5
5) Tetrabtomobisphenol A
CAS No. 79-94-7
6) Phenylenediamine
CAS No. 95-54-5
7) Methyl ethyl ketoxime
CAS No. 96-29-7
8) Vinylcyclohexene, 4-
CAS No. 100-40-3
9) Phenylenediamihe
r,
10) Trimcttaylbehzene, 1,3,5-
CAS No. 108-45-2 CAS No. 108-67-8
ID 2.4.6-Tfibromophenol 12) Trihuivfl phosphate
CAS No. 118-79-6 CAS No. 126-73-S
13) Crown uldehyde
CAS No. 4170-30-3
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OCT-16-1996 10!33
UISTA SFTY HLTH & ENUIRON
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C) The following 11 candidates are TSCA 4 chemicals for which there was a DNT (decision not to test; between 1980-1990 based on estimates of limited exposure potential. AIlore high production volume chemicals for which toxicity/fate data gaps were identified in the past. The first four are from a Section 4 category of organotin compounds. -
1) Dibury0 ltin S.S'-bis(isooctylmercaptoacetate) 2) Monobutyltin tris(isooctylmercapcoaceiate)
CAS No. 25168-24-5 CAS No. 25852-70*4
3) Diinethyltin 5,S'-bis(i$ooctylmercaptoacetate)
CAS NO. 26636*01-1
4) Monomethyltin tris(isooctylmercaptoacetate)
CAS No. 54849-38-6
' 5) Formamide
CAS No. 75-12-7
6) Nitrobenzene
CAS No. 98-95-3
7) 1.2-Bi4ylene oxide
CAS No. 106-88-7
8) Pyridine
CAS No. 110-86-1
9) Chloretidic acid
CAS No. 115-28-6
10) Isopropylbipheayl
CAS No. 25640-78-2
ID Diisoptopylbiphcnyl
CAS No. 36876-13*8
D,i The following nine candidates are high production volume chemicals that were the subject of submissions under TSCA 8(e). The chemicals have been identified as hazard concents based on preliminary EPA evaluation.
U Hexahydrophthalic anhydride - Sensitization
CAS No. 85-42-7
2) Dimeth(ylurea - Chronic Toxicity
CAS No. 96-31-1
1 -Hcxanol - Subeltronie Toxicity
4) Tctrahydronaphthalene - Dermal Sensitization i
CAS No. 111-27-3 CAS No, 119-64-2
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UISTA SFTY HLTH & ENUIRON
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5) 6) 7) 8) -^9)
N*f l.3-Dimcthvlbutyl)-N`-phenyl-l,4-benzenediamine ; - Dermal Sensitization
CAS N'o. 793-24-8
Triglycidyl isocyanurate \ - Reproductive/Genotoxic Effects
i
N'-0,4-Dtmethylpentyi)-N'*phenyl-p.phenylenediamine
- Dermal Sensitization
*
CAS No. 2451-62*9 CAS No. 3081-01-4
N.N'-bis(1.4-Dimethylpentyl)-1.4-benzenediamine - Demial Sensitization
CAS No. 3081-14-9
1-Hexadecanol i * Subchronic Toxicity
CAS No.36653-82-4
E) The followinjr.24 candidates are Toxics Release Inventory (TRI) chemicals (produced at > 104 *po6u*nd8s) that have TRI releases > 104 pounds annually(HPR chemicals). In 1993, CMA committed to handle 10 HPR TRI chemicals under the SIDS program. To date, CMa and US industry have sponsored 4 of the HPR TRI chemicals supplied by EPA.
The Agency recognizes that a number of these chemicals are the subject of ongoing actions under 4 but. nonetheless, encourages industry to consider handling the chemicals under the SIDS program.
1) Carboit tetrachloride 2) Methanol
3) 1.1,1-Trichioroethane (being phased out)
4) Bromornethane (subject to 19S7 UN Montreal Protocol)
51 Chloromeihone 6) Chloruethane
) Vinyl Chloride 8) Dichlwsomeiiiune 'h tcrt-Buty! alcohol
CAS No. 56-23*5 CAS No. 67-56*1 CAS No. 71-55-6
CAS No. 74*83*9
CAS No. 74-87-3 CAS No. 75-00-3 CAS No. 75*01*4 CAS No. 75*09*2 CAS No. 75-65*0
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10) 1.2-Diphloropropane
11) Picric Acid 12) Biphenyl 13) o-Xylene
l 14) l .2.4-trimethylbenzene 13) 1.2-Dichloroethane 16) m-Xylene 17) Chlorobenzene 18) Propylene
t. 19) Carhopyl sulfide 20) Cresollfmixed isomers)
20 Xylene (mixed isomers) 22) Ammonium nitrate 23) Ammohium sulfate 24) Chlorine Dioxide
CAS No. 78-87-5 CAS No. 88-89-1 CAS No. 92-52-4 CAS No. 9547-6 CAS No. 95-63-6 CAS No. 107-06-2 CAS No. 108-38-3 CAS No. 108-90-7 CAS No. 115-07-1 CAS No. 463-58-1 CAS NO. 1319-77-3 CAS No. 1330-20-7 CAS No. 6484-52-2 CAS No. 7783-20-2 CAS No. 10049-044
k. F) The Agency wfcs petitioned by the United Auto Workers to initiate a testing program for
metalworking fluids. NIOSH submitted a list of ninety five chemicals for EPA's consideration. -The list was composed of commonly used ingredients in metalworking fluids identified by industry. EPA screened the list of chemicals for further examination by identifying jthose with the highest US production volume. The following 19 chemicals
(taken from the screened list of 22 chemicals) are not involved in the SIDS program and arc therefore candidates for sponsorship.
1) Prop\ Idne glycol
CAS No. 57-55-6
2) Hutytatipd Mydroxyioluene (BHT)
CAS No. 126-37-0
>) titluno(imiiitf (MEA)
CAS No. 141-13*5
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4) Buianetiioic acid, sulfo*. t,4-bi$(2S') Potassium hydroxide 6) Tall oil
CAS No. 557-1 1-7 CAS No. 1310-58-3 CAS No, 8002-26-4
7) Sodium iignosulfonale
CAS No. 8061-51-6
-^>8)
Senzetiesulfonic acid, dodecyl-, sodium salt
CAS No. 25155-30-0
9) Dipropylene glycol
CAS No. 25265-71-8
10) Neodeoanoic acid
CAS No. 26896-20-8
^>11) 12)
Fatty acids, tallow, Me esters
F
Alkanes, chlorinated (Chlorqalkanes)
CAS No. 61788-61-2 CAS No. 61788-76-9
13) Oils, lard, sulfurized
CAS No. 61790-49-6
14) Paraffin waxes & hydrocarbon waxes, chlorinated j(Chlorinated paraffins)
CAS No. 63449-30*8
->15) Petroleum distillates, hydrotreated light
16) Distil lojes(petroleum). hydrotreated heavy tiaplithenic
17) Fatty adids. tail-oil. terra esters with pdntaerythritol
18) Alkenes. Cl2-24. chloro (Chlorinated olefins)
19) Mineral; oil Sulfonic Acids, Sodium Salts
CAS No. 64742-47-8 CAS No. 64742-52-5 CAS No. 68334-18-9 CAS No. 68527-02-6 CAS No. 68608-264
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UISTfl SFTY H-TH & ENUIRON
P.000/010
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G) The following chemicals have been identified for preparation of Toxicological Profiles by the Agency for Toxic Substances and Disease Registry under the Superfund Amendments and Reauthorization Act <;SaRA> 1 tO. The ATSOR has not completed Toxicological Profiles on these chemicals and completion of SIDS testing and assessment would contribute in a useful way
to this effort. Note thjat a number of these are used as pesticides but appear on the OECD's HP V list.
1..) Phosphorothibic acid. 0,0-diethyl-0-(4-nitrophenyl) ester CAS No. 56-33-2
2.) Ether
p
3.) Methane
\ 4.) 1,3-cyclopentadiene. 1,2,3,4,5.5-hexachloro-
CAS No. 60-29-7 CAS No. 74-82-8 CAS No. 77-47-4
5.) Phthultc acid, benzyl butyl ester
CAS No. 85-68-7
6.) Benzene. 1.2.3-trichloro-
CAS No. 8/-61-6
7.) Acetic acid. C2,4-dichlorophenoxy)-
CAS No. 9-1-75-7
3.) Phenol. 2-chloarot
9.) Ethane, dichloro
10.) Calci um hypothorite
CASNo. 95-57-8 CAS No. 1300-21-6 CASNo. 777S-54-3
11-) Chlorine 12.) Toluene. ar-chJoro-
CASNo. 77S2-50-5 CASNo. 25168-05-2
13.) Bcnzcne. dichloro
CASNo. 25321-22-6
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SL 110132