Document O3xMoDJbX6Qeqryk9mMp0w52e
AR226-2783
FOR DO PONT QSE ONLY
H askell LaEb.orZa.toEdruly:fP:iooamnrnrtkRTd,ooaaxDdiNc,eoleaPlmow.ogauOyrre.sanBadn1o9dx7I1n5C10do,u.,stIrniacl. Medicine
HASKELL LABORATOni REPORT HO. 537-82
OamcmtaonnoiuMlmc aasteacrliidta,l p.t.e.e.s.n.t.e.e.add*ecafluor!o-,
Ba1s2ic,0e3li7 KT7
(13,584
O<ther 'Code~s
Study6/2I/n8i2tl-a6t/e1d6//C8o2apleted
M aterial Submitted by Haskell Laboratory
FOURTEEN-DAY FEEDING STUDY IN MALE AND FEMALE MICE
Aatormltlaomnl iauolmef a3pn0edrpfXpfe:mauCmt,oDar1d(-o11o-o5scnmetpaatplnelmeeeovadeeataenilecs)dsdhaa!|ptfteowfm3r3i0e0ta0h2il05tpeihnpmaaemnn1riddo2c3er3d500atw0h0py0epes,rmpepa32mef0faett.0eecd,hrs)e3t f0ietmf,heoedarl:(itneP1gr4oi.arclos3ncpsopemmcu,btiionvered dfoayr sa. twppthopohmeetbnetednwciLtdodoiimoavmnslepseoraa-trtfeweordareerliilattgaoeclhtsaretut/dhbtstehoeinsewdtgcyeeoidlwftnlfrteewrfiocg^lth^^sst^^i-^.r^a^MTt^imhoHiexsimn^| |g|Ja^htto^hHewredeiHdae2l saBatnea^BpsI nUptBceerabjearrateeestioernri ahagelatenvlceaahelrneslgdiemmlmefomivelrmeaneirtllftsnoaxp*t epi csetaeordsf
Purposet To determ ine: ^ aee lATCTihhtoveemeweprthoafarfextiensiodclcanotirstsgyoeeofmlfetehvmneeitx.lasinbgliilvwietyirthoenafmlatmrhgoeneimu2metneptseitrsfmlupaortoreodruoiacceltsadn, tooatper.oduce
1- -
1
bawfwPnooereddorriyegc'l1heiwo4idvnbueecgsiroreger2nh:vw4stese-ed3Fciw5guicfhetgtiortvyse)ne-crfrueeievcrcarrooyeaerrsnddgs.teeorldodylueTapaaentoeat!ljdnfjtltfejd0ttgihndif,erneeo5oidme5t7uaot1p,tiaeofcs4e9re2n-myoad2laywaftanglyleemdge3rrvorse0aoeauC1lupe4hlpcrnsjolsrsdadu,iiionafs:ioieP5yfCdcdrsuIeme2,HrmiI.iintgncchiamreldxoieitinuLpvrucpieaericbd3seras0(uaoCsl0ageofh0lxseofl,iWyfge43pt*mnha40e.nser0add,lreaI2en3fyraeomcd0edduo,i,avpndti1,ted0arruboiiolyaalysrlls
R esults : Male Mice
H-13.584)
DosPePmLevel AT'v'AHerefaetgEeer" "FBZeoed'Udyimn(igbPig(gh)ts
L(igv)e r
3300031000030
333231338204
*3233*9656
I 1!;
-
* * I!
4332....00801185
Ammonium perfluorooctanoate (8-12,037)
Dospepmle v e l
30
A1 vAWerefaetgeker FB2eoedWdyine(egbk!sig(gh)ts
31 33
Average Liver ***** (g> 454
A(gv/BleOoradOgyge(bLiigBvheodrt yR(b(abitgiioghht/t) 11-8630....04641846
A(gv/BleOoradOgyge(bLBiigvohdeytr R((bbaiitggiohhtt)/ 13.68
DospepmLevel 1525/5/21/555
ionium perfluorooctanoate (g-13,584/H-12,037)
A1 vA(ebrfeatlgeter FB2eoedd(ybine(glbt!isig(gh)ts 333133 333434 |j|
Av(ebriagghet-L(igv)er . 444...845330
A(gv/BleOordaOygge(bLBiigvohdeyrt R((bbaiitggiohhtt)/ 111433...104283
)
2-
Conipar/ s.
;>
Results : Female Mice
H-13,584)
DosPePmLevel 3030031000030
A1 vAWerefaetkgeer
FBeoedyd
in(bs
ight
(g)
s
2 Ukelcs
211222657676
2*
**23443
Avesraigghe
t
Liver
(g)
3321....0426811?
Ammonium perfluorooctanoate (H-12.037)
AvfieftrralVgeUL*4tifvrleeb>r D(beiagdh. t/ ( g / 1 0 0 g Bodv U>4<rh<^
117035....46877671
DosPePmLevel A1 vA(ebrfeatkgeer FB2eoedHdyienegkbsig(gh)ts Av(ebraigghe tL(igv)er A(gv/B1eor0ad0gyge(bLBiigvohdeytr Rttaiitggiohhtt)/
3.65 13.29
DosPePmLevel 12555//21/555
glum gerfluorooctanoate (H-13,584/H-12.037)
A1 vA(ebrfeatkgeer FB2eoedVdyibnfeglkisg(ha)ts 222667 222888!'
Av(ebriagghe t L<iv)e r 433...178391
A(gv/B1eor0ad0gyge(bLBiigvohdeytr R(btaiitggiohhtt)/ 111433...565313
** All animals died at th is dose level
* H-12.037
- 3-
* H-13,584 Furiti CAS R egistry Number:
Saport by: \ a A A /JoThe^nVchrEn.icHiaennry
!Reviewed by: !Approved by: O
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