Document O3qXnveb14Y7zKjamnBEzy4pK

From: Sent: To: Cc: Subject: Attach: Matt Todd <ToddM@api.org> Wednesday, February 19,20037:40 PM (GMT) BHRC Technical Committee (E-mail) <benzconsort-tc@api.org> Matt Todd <ToddM@api.org>; Jim Vail (E-mail)<brec@rockbridge.net>; Bruce Jarnot <jarnotb@api.org> BHRC Technical Committee: Irons Progress report Bilingual Worksite Inspection I.doc; DB EA EP Prog Rep2.doc BHRC Technical Committee Members: Attached is Dr. Irons progress report and Workplace Inspection Form (mentioned in Jim Vail's email message below). These documents will be posted on the Technical Committee page on the Shanghai Health Study website. In addition, the Second Level Questionnaire Documents will also be made available on the website by the end of the week. Thanks. Matt Todd BHRC Communications Bilingual Worksite Inspection 1.doc -----Original Message----- From: Jim Vail Sent: Thursday, February 13, 2003 11:07 AM To: Matt Todd Subject: Irons Progress report Matt: I am attaching the original version of the Irons progress report and in this case, I would like you to put it in the Technical Committee website and email them that it is available. Also, please let them know that we will try to obtain the missing "workplace inspection form" and will post this to the website, once in hand. Thanks for your help, - Jim DB EA EP Prog Rep2.doc [Matt Todd] SH ELL-MCCLU RG-054308 PROGRESS REPORT JANUARY 2003 1. ANALYSIS OF DISEASE PROGRESSION FOR APLASTIC ANEMIA, MYELO-DYSPLASTIC SYNDROME, ACUTE MYELOGENOUS LEUKEMIA AND BENZENE POISONING IN SHANGHAI, CHINA II. MOLECULAR EPIDEMIOLOGY OF BENZENE-EXPOSED WORKERS IN SHANGHAI, CHINA A MULTICENTER INTERNATIONAL STUDY Molecular Toxicology and Environmental Health Sciences Program Dept. of Pharmaceutical Sciences, School of Pharmacy Department of Pathology, School of Medicine University of Colorado Health Sciences Center, Denver, CO. School of Public Health, Hua Shan Hospital, Cancer Hospital, Fudan University Medical Center, Shanghai, China SH ELL-MCCLU RG-054309 I. INTRODUCTION A. Executive Summary 1. Overall Status of Budget NOTE: All of the budget projections cited in this report are derived from the updated budget projections provided to API in September 2002. A copy is included in appendix A for your convemence. The overall status of the budget for this fiscal year is as follows: As of December 31, 2002 we have received $7,515,759 against a current budget of $4,617,530, exclusive of field expenses. Of the $4,617,530, $3,248,834 has been paid as of December 31, 2002 with $888,121 sequestered for payment. This leaves a balance of $480,575. Table 1. Budget Summary Category Budgeted1 Spent Unpaid Difference Personnel $745,300 $710,788 $0 $34,512 Operating Expenses $391,593 $305,422 $4,396 $81,775 Subcontracts $1,918,659 $1,025,372 $663,525 $229,762 Travel $23,947 $8,647 $0 $15,300 Equipment $1,210,213 $899,642 $219,057 $91,514 Indirect $327,818 $298,963 $1,143 $27,712 TOTALS $4,617,530 $3,248,834 $888,121 $480,575 1,The budgeted amounts are the sum of each category from Dec-01 through Dec-02. The unpaid operating, equipment and overhead expenses are transactions in progress as of 12/31/02 that require the funds to be encumbered. The unpaid subcontracts include $372,225 due to EMBSI for year 2, and $155,660 and $99,989 owed to EMBSI for the SRP approved increases in their budget for years 1 and 2, respectively. Approximately, $35,651 is required to complete the Children's Hospital's contract though 12/31/02 for a total of $663,525 in unpaid budgeted contract funds. The $255,649 due EMBSI as a result of the post SRP budget can only be paid upon revision of the API contract with UCHSC to include post- SRP related costs. We have maintained a positive budget balance through successful negotiations with equipment and supply vendors. In addition, in order to minimize shipping costs, we have contracted with Asian distributors when possible. Travel expenses incurred by the trainees were reduced by minimizing the number of trips that the trainees took between UCHSC and JCML. 2 SHELL-MCCLURG-054310 2. Projected We currently see no need to modify the projections for Jun-03 as stated last year (appendix A). There will be increased supply costs to stock the laboratory with clinical supplies/reagents, however, the budget carryover into the Jan-Jun -03 budget period will be sufficient to pay for these costs. 3. Budgetary and contractual issues To date, API has not provided UCHSC with contract addenda to reflect the modified budget changes following the SRP review. Therefore, we cannot modify our contracts and payment schedule to EMBSI to reflect their actual costs schedule. II. EQUIPMENT A. Overview All equipment that is necessary for the startup of JCML laboratory operations has been received. The TQ-Prep System is in process for shipment and is expected to arrive at JCML by March 1, 2003. Additional equipment and/or subcontracts are currently being evaluated as a means to enable JCML to better support Chinese occupational benzene worker examinations. The resolution of these issues will be addressed in the next progress report. Installation of flow cytometry, hematology Cell-Dyn and immunoanalysis equipment, as well as microscopes, has been completed. Final installation of cytogenetics equipment has been delayed due to reagent import issues but is expected to be completed before the end of February. B. Budget Table 2. Equipment Summary Vendor Equipment Budgeted Abbott Blood analyzer $65,000 Abbott IMx (HIVIHBVIHCV) $20,000 Beckman Coulter Centrifuges $34,750 Beckman Coulter Flow Cytometer $162,500 Beckman Coulter TQ-Prep (sample prep for FIc China Sc Ventana Discovery/Benchma $205,000 Technology LTD /Special stains units Paid Unpaid $65,518 $20,000 $45,035 $145,965 $34,660 $220,000 Status AtJMCL AtJMCL AtJMCL AtJMCL In Process AtJMCL Gene Company Imaging system $195,000 Gene Company Thermal Cycler $10,000 Gene Company Denatureation IHybridiza $5,000 System for FISH Great Systems Tecl Deionizer Water System $5,000 Rae Systems Benzene Monitors $20,000 $195,000 $6,500 $10,500 $16,268 $20,000 AtJMCL AtJMCL AtJMCL AtJMCL AtJMCL 3 SHELL-MCCLURG-054311 Scientific Instrurr Olympus Microscopes $28,145 AtUCHSC Co Taiyo Koeki Olympus Microscopes $65,000 $48,195 AtJMCL Tecan US Coverslip harvester $29,500 $30,500 AtJMCL Tech-Knowledge Slide stainerlLyophlizer/ $25,554 $33,510 AtJMCL Solutions Refrigerator Thermatron CDS-5 Drying Chamber $12,000 $16,950 AtJMCL Thermo Life Incubators/laminar f $195,957 $172,573 AtJMCL hoods/freezers/rate freezer/liquid nitro storage/alarm system S&F (Shang Electrophoresis /Transfer set $ 5,000 $4,134 AtJMCL International Trad Co., Ltd. Total $ 1,055,261 $895,586 $217,867 C. Supplier Agreements JCML has completed agreements with Gene Company (Vysis), Genetime Technology, Inc., American International Medicine, Inc., and Tech-Knowledge Solutions. Reagents such as FISH probes, monoclonal antibodies, cell culture reagents as well as general laboratory supplies are easily obtained. In addition, agreements for clinical supplies are in process and will be completed by March. Gene Company distributes products in China for the following companies: AB Gene Affymetrix AMS: Mmunokontact Becton Dickenson / Falcon BioWhittaker BioTrin BioWest Calbiochem CLP Continental Lab Products Corgenix (Reaads) DAKO Eppendorf Epicentre Technologies Genset Hyclone Intergen, Inc. Integra Biosciences Kimberly-Clark Kontes& Kimbles Miltenyi Biotec Molecular Probes Oncogene Research Partec Pierce Qiagen Robbins Scientific Santa Cruz Biotechnology, Inc Schleicher& Schuell Treff USA Scientific Vysis Worthington 4 SH ELL-MCCLU RG-OS4312 Genetime Technology, Inc. distributes products in China for the following companies: ABgene Amresco Arista Biologicals Biodesign BiosPacific Cell Signaling Technology (CST) Chemicon Clontech Corning Endogen Fitzgerald Industries Ryclone Immunetics IntergeniSerologicals JT Baker Labnet Neuro Probe Omega Biologicals Origene Technologies PBL laboratories Peprotech porex Pragmatics R&D RDI (Rapid Diagnostics/ICN Biomedical) Rockland Sigma Trevigen III. LABORATORY A. Personnel The startup phase of laboratory personnel training at UCRSC is reaching completion with the last two trainees scheduled to return to Shanghai in late March/early April. Recruitment of personnel necessary for laboratory start up is virtually complete. Methods standardization and validation of laboratory procedures is underway at the present time. B. Database Server computer hardware has been installed at Fudan University and UCRSC. Serial application for moving data from the Cell-Dyn to the Server has been developed and will be deployed on the PC networked with the Flow Cytometer and Cell-Dyn. Configuration and testing of the Server & Serial port application is underway. Core clinical applications are almost completed including laboratory management, patient accession and testing with clinical forms and exposure assessment components in final stage of development. Questionnaire and exposure assessment modules are also nearing completion. We have adopted a Bar code system to facilitate sample identification and patient acceSSIOn. 5 SHELL-MCCLURG-054313 IV. SUBCONTRACT SUMMARY Table 3. Subcontract Summary Subcontracts 1 Fudan 2 SIPHS 3 SMCDCP 5 EMBSI 6 Children's Hospital TOTALS Budgeted $538,525 $139,995 $154,716 $982,374 $103,049 $1,918,659 Spent $404,538 $124,059 $80,175 $354,000 $62,600 $1,025,372 Unpaid $0 $0 $0 $627,874 $35,651 $663,525 Difference $133,987 $15,936 $74,541 $500 $4,798 $229,762 Due to a central government-mandated reorganization, certain functions previously provided by IPHS are being reassigned to SMDCDP and Fudan University. Accordingly, we will be redistributing resources necessary to support these activities over the course of the next quarter. We anticipate that, with minor exceptions, this will be a "budget-neutral" exercise. V. BENZENE METABOLITE PILOT STUDY We have conducted the planned pilot study to develop and evaluate a sensitive method for the analysis of benzene metabolites in human blood and bone marrow. After initial developmental work, we ultimately have settled on a liquid-liquid extraction method coupled with electron capture GCMS. Using this method we have successfully quantitated phenol, catechol and hydroquinone in blood and bone marrow of human subjects not occupationally exposed to benzene. We have standardized and validated the procedure with cold labeled isotopes and established standard curves for each analyte in small volumes of blood and bone marrow. Precision, accuracy and sample stability have also been determined. This study was an unqualified success and has resulted in the development of a very sensitive and reliable method that is currently being transferred from UCHSC to the Shanghai CDC. A manuscript detailing the method is in the final stages of preparation and will be submitted to the SRP for review sometime in the near future. A second manuscript describing background levels and tissue distribution of benzene metabolites in unexposed subjects is also being prepared. We believe that these papers will provide new and fundamentally important information on the metabolism of benzene and its metabolites in humans that will have an immediate and significant impact on the field. Methods of analysis for PMA and tt-MA are being developed at this time. VI. EXPOSURE ASSESSMENT Initial training for exposure assessment was begun in September, based on English materials translated to Chinese and presented in Mandarin at Fudan University. The course covered an overview of the projects, and details on exposure assessment for subject work histories and related workplaces. The primary course goal was to prepare the inspection teams to develop information 6 SH ELL-MCCLU RG-OS4314 about the exposure history of subjects from the case-control and DP studies (CC-DP). This exercise resulted in a re-evaluation of our strategy to integrate procedures that incorporate existing Chinese approaches and has led to a much more collaborative process among the participating organizations. Hands-on training for rudimentary ventilation system checks was conducted using smoke tubes and UltraRAE selective detectors. These instruments were delivered to IPHS in September. Following the course, we redesigned the workplace inspection form that guides the collection of fundamental information needed to support retrospective assessment of exposures. This form is now bilingual, and has been tested by actual workplace interviews of workers. (Copy of form attached). We plan on providing and retaining this form electronically via the study database. We will use it for wider orientation and on-site training of additional IPHS staff in January and February. Personal exposure monitoring is not yet a national standard in China. That will have to be adopted by CDC and Fudan as part of our project requirements. We will provide training on designing and conducting personal monitoring-based exposure surveys. Recruitment and training of Exposure Assessment Team personnel is underway at Fudan University and should be complete by the end of Februarylearly March. The primary questionnaire for use in the CC-DP studies is in the database in bilingual form. Data entry into a test version of the database has been completed, with no significant changes needed. Minor changes are being evaluated to facilitate language issues. We are designing an extracted version of the questionnaire that will be obtained from the database for use in assessing exposure history. We plan to have that summary of work history and exposure -related information from the questionnaires flow electronically to the exposure assessment committee. The extract will give the exposure assessment teams the information relevant to the subject's workplace, possible materials to which they were exposed, and information on their tasks. The summary will not include confidential information, such as medical history. Several additional initiatives are underway, via graduate student research projects or via contacts elsewhere in China. These include analysis of consumer paint exposure surveys and the application of expert elicitation and uncertainty analysis using Bayesian statistical approaches for dealing with subjective data in an exposure assessment. VII. EPIDEMIOLOGY We have refined and clarified epidemiologic design and site selection strategies for the Molecular Epidemiology study. We have conducted several pilot tests of Disease Progression interview procedures in order to improve questionnaire design and have performed second level pilot testing to evaluate and train in-hospital questionnaire takers. In addition, we have initiated training of clinical coordinators and established instructions for the selection and recruitment of subjects and controls. Final training of clinical coordinators will be conducted at the end of Februarylbeginning of March. We have initiated and guided a study to characterize previous acute benzene exposures in Shanghai that will aid in the conduct of ME Phase 1 and the selection of factories in Phase 2a. In 7 SHELL-MCCLURG-054315 addition we have established a Factory Selection Committee and provided procedures for selecting factories to include in the ME study. This has included drafting ME abstraction forms for Phase 1, and questionnaires for Phase 2. The latter has now been fully integrated into the clinical examination form used by CDC in conducting benzene worker physical exams. VIII. REGULATORY HARMONIZATION AND LICENSING Final COMIRB and Fudan IRB approval was obtained for protocols and informed consent forms as of November 2002. However, last minute modifications in IC for the Molecular Epidemiology study and new consortium requirements for incremental ERP and SAP review necessitate one more round of approvals. We hope to be able to submit these changes to COMIRB as soon as possible in order to have the opportunity to start the studies in March. If we are unable to begin recruitment of cases in March, scheduling difficulties may require that we postpone startup to April or even June. During the fourth quarter of 2002 I also traveled to Beijing to meet with Chinese central government officials and the Ministry of Health. They provided me with important information that we previously did not have on licensing requirements for foreign research collaborations and laboratories. Fudan University and JCML have applied for and are in the process of obtaining the necessary licenses for operation. 8 SH ELL-MCCLU RG-054316 Oec-01 Jun-02 AppendixA. Budget Projections provided to API in September 2002 Budgeted $648,390 $1,381,197 9 SH ELL-MCCLU RG-OS4317 JltiiJ.Ii!f~ Worksite Inspection subject ( case/control) data: ~ :g name _ _ _ _ _ _ __ t1 ~~ sex:_ _ _ _ _ _ _ __ } .1.JiftliA/~)5t did this person work at this factory? o ~ yes 0 7[; no 0 1')~~ do not know ~~i!f.1}rJit*ffi)5t company basic information: ibll!.:g~ (lWffl:g~lt{m:g~) _ _ _ _ _ _ _ _ _ _ _ _ _ __ name of company M Jt_____________ address Eg i! telephone _ _ _ _ _ _ __ ti~~i!f~IAffi)5t ( interviewee data) ~ :g name - - - - I~~ ( ijR~ ) job title _ _ _ _ _ _ __ jEPX~i!f~~Itt=ADiffi)5t ( interviewer data) ~:g name jEpx S ~~ interviewing date {~2~B11B] ( revision date): 2002-11-21 SHELL-MCCLURG-054318 2 SHELL-MCCLURG-054319 I~ job title 1 - - 1f~~ ~ task title *~ B'.t 7f~ l3 ~ : from before ;a l3 ~ : to now 3 SH ELL-MCCLU RG-054320 I t1=!WiJJt frequency of task I t1=!WiJJt frequency of task ~gJE~f= stable production (~~~ f=*~*~~) ~~JH1 periodicity (1'~B11B]1'{E ~H$C~Jf) ~gJE~f= stable production (~~~ f=*~*~~) ~~JH1 periodicity (1'~B11B]1'{E ~H$C~Jf) D~~ several days D~~ several days D~~ several weeks D~~ several weeks D~.F.I several months D~.F.I several months (:J:i~) please describe in detail (:J:i~) please describe in detail difference predictable or random? difference predictable or random? work hours per day? _____ work hours per day? _ _ __ ~ ~ I t1=JL~ work days per week? ~ ~ I t1=JL~ work days per week? of times for break? of times for break? time(in minutes) _ __ ~fF~~j>1I1i S holidays per year _ _ _ _~/fF days/year time(in minutes) _ __ ~fF~~j>1I1i S holidays per year _ _ _ _~/fF days/year pJT?Where did workers take breaks or have lunch o {E I t1=~ pJT work area pJT?Where did workers take breaks or have lunch 0 {E I t1=~ pJT work area dedicated lunch or break area far from work area dedicated lunch or break area far from work area 4 SHELL-MCCLURG-054321 o !t t?:1BJJ (J:IJ)some place else (describe) 0 !t t?:1BJJ (J:IJ)some place else (describe) ~.~~.~.~~M~,~~~A ~~~~~~,~~B1'~~~? ~.~~.~.~~M~,~~~A ~~~~~~,~~B1'~~~? If breaks elsewhere, was it well ventilated If breaks elsewhere, was it well ventilated o ~ yes 0 ~ noD 1')~~ do not know 0 ~ yes 0 ~ noD 1')~~ do not know 1~ /\~t~U~: source of information o ic~ records of factory o Iq] $ Q ~ by interviewee 1~ /\~t~U~: source of information o ic~ records of factory o Iq] $ Q ~ by interviewee ;a*chemicals l3 ~ : to 1. 4mEt chemical 1 _ _ __ ffl~ quantity _(/~ ~ ,.F.I ,fF) (/day, week month, year) ~ ~ ~*/~I.R,(percentage of benzene content) % 2. 4mEt chemical 2- - - - - ffl~ quantity_(/~ , ~ , .F.I , fF) (/day, week month, year) ~ ~ ~*/~)5t(percentage of benzene content) % 3. 4mEt chemical 3 _ _ __ ffl~ quantity_(/~ , ~ , .F.I , fF) (/day, week month, year) ~ ~ ~*/~)5t(percentage of benzene content) % 4. 4mEt chemical 4 ffl ~ quantity_(/~ , ~ , .F.I , fF) (/day, week month, year) ~ ~ ~*/~)5t(percentage of benzene content) % chemicals 1AmEt chemical 1 - - - ffl~ quantity (/~ ~ ,.F.I ,fF) (/day, week month, year) ~ ~ ~*/~ )5t(percentage of benzene content) % 2.4mEt chemical 2_ _ __ ffl ~ quantity_(/~ , ~ , .F.I , fF) (/day, week month, year) ~ ~ ~*/~ )5t(percentage of benzene content) % 3.4mEt chemical 3 - - - - ffl ~ quantity_(/~ , ~ , .F.I , fF) (/day, week month, year) ~ ~ ~*/~ )5t(percentage of benzene content) % 4.4mEt chemical 4 ffl~ quantity_(/~ , ~ , .F.I , fF) (/day, week month, year) ~ ~ ~*/~ )5t(percentage of benzene content) % 5 SH ELL-MCCLU RG-OS4322 5.4mmt chemical 5 _ __ ffl~ quantity_(/~ , ~ , .F.I , fF) (/day, week month, year) It ~ ~*/~I.R,(percentage of benzene content)- - -% 1~ /\~t~U~: source of information DlC~ records of factory o Iq] $ Q ~ by interviewee 5.4mmt chemical 5 _ __ ffl ~ quantity_(/~ , ~ , .F.I , fF) (/day, week month, year) It ~ ~*/~)5t(percentage of benzene content)- - -% 1~ /\~t~U~: source of information o lC ~ records of factory o Iq] $ Q ~ by interviewee 6 SH ELL-MCCLU RG-054323 t1=.il103~ production method 0 ~~I7fJ completely enclosed *'0 ~ 17fJ partly enclosed 0 ~7f~ open 0 z;l] f!j automatic 0 -I1'*t1= manual 0 ~~.1'*t1= remote 1~ ,\~t~U~: source of information Dic~ records of the factory o ~ ~ Q J by interviewee t1=.illL1.J~ production method 0 ~~I7fJ completely enclosed *'0 ~ 17fJ partly enclosed 0 ~7f~ open 0 z;l] f!j automatic 0 -I1'*t1= manual 0 ~~.1'*t1= remote 1~ ,\~t~U~: source of information o ic ~ records of the factory o ~ ~ Q J by interviewee *~~JJt~~ data of benzene concentration J/!IOy/s7 measure time J/!Ift!J/(l measure location #*1& samples max. mm.E3 ... /,5 lfIXfBllE1 E3 /,:1:/,5 lfIXl'=~lE1 . SfZ~m average *~~JJt~~ data of benzene concentration J/!IOy/s7 measure time J/!Ift!J.ll measure location #*1& samples max. mm.E3 ... /,5 lfIXfBllE1 E3 /,:1:/,5 lfIXl'=~lE1 . SfZ~m average fPftj:(if you can get such benzene concentration data, pis make copy as above) 1 =i' ,1,,3,,731I'z,}~/f1i!i\ source of data o IJic~ from factory records o !MitiPJT~fj.W: from IPHS database fP ftj:(if you can get such benzene concentration data, pis make copy as above) 1 =i' ,1,,3,,731I'z,}~/f1i!i\ source of data 0 IJic~ from factory records 0 !MitiPJT~fj.W: from IPHS database 7 SH ELL-MCCLU RG-OS4324 Did skin contact with the above chemicals (1-5)? or a lot) o 1'~m do not know Did skin contact with the above chemicals (1-5)? or a lot) o 1'~m do not know 8 SH ELL-MCCLU RG-054325 lJJJ:lPffi)~ preventive measures: 7f~l3~ : from ;a*l3~ : to o JMJX\. ventilation 1.7f1l ( 11'Q\Z~1' ) open window O~ yes OS no 01'~m do not know 2.11 L.~~~~ ? fan in window? O~ yes OS no 01'~m do not know 3. ~tt!?,~ fan on floor O~ yes OS no 01'~m do not know 4.~.g.~~~JX\.~[I local exhaust system O~ yes OS no 01'~m do not know 5.JX\.5fl~ ( Q\ZJX\. ) air curtain O~ yes OS no 01'~m do not know lJJJ:lPffi)~ preventive measures: o JMJX\. ventilation 1.7f1l ( 11'Q\Z~1' ) open window O~ yes OS no 01'~m do not know 2.11 L.~~~~ ? fan in window? O~ yes OS no 01'~m do not know 3.~tt!?,~ fan on floor O~ yes OS no 01'~m do not know 4.~.g.~~~JX\.~[I local exhaust system O~ yes OS no 01'~m do not know 5.JX\.5fl~ ( Q\ZJX\. ) air curtain O~ yes OS no 01'~m do not know enclosed room with fan or exhaust system? O~ yes OS no 01'~m do not know enclosed room with fan or exhaust system? O~ yes OS no 01'~m do not know dedicated ventilation system O~ yes OS no 01'~m do not know dedicated ventilation system O~ yes OS no 01'~m do not know 8.~~~[I air conditioning 8.~~~[I air conditioning O~yes OS no 01'~mdo not know9. It{m ( fi~ ) other(describe): O~ yes OS no 01'~m do not know 9.lt{m ( fi~ ) other(describe): 1O.JffiJX\.~~$C ~ ~~ effects of ventilation 1O.JffiJX\.~~$C ~ ~~ effects of ventilation o1LUT very good 0 -~~ just so-so oJVf)9:~ hardly any effect o1LUT very good 0 -~~ just so-so oJVf)9:~ hardly any effect 01'AiJJ'j~ffl~ 01'AiJJ'j~ffl~ 9 SH ELL-MCCLU RG-054326 011r,~13JJ1f'1X protective clothing 02 ~q&~ respirator 03 13JJ1f' Q ~ mask 04 ~~-~ plastic glove 05 !tim ( j:iJ ) other(describe) l3JJ1f'i~nTh PPE O~~lEliftJ right type OlEliftJ1fffl right use O~;lO'&jlf in good order 1~,~3~5!* source of information o tc.~ factory record o rq]$Q~ provided by interview 011r,~13JJ1f'1X protective clothing 02 ~q&~ respirator 03 13JJ1f' Q ~ mask 04 ~~-~ plastic glove 05 !tim ( j:iJ ) other(describe) 13JJ1f' i~nTh PPE O~~lEliftJ right type OlEliftJ1fffl right use O~;lO'&jlf in good order 1~,~,*5!* source of information o tc.~ factory record o rq]$Q~ provided by interview 10 SH ELL-MCCLU RG-OS4327 Qualitative Ranking of Exposure(~H.B'9 JEml.1i!i") Before From - - To - - Now j..::t~tr ~A 1~ B'f 7f Ms jH~ B'f .Lt Would exposure be best described as: ~H. 0 none )t~ 0 none )t~ 0 slight $.~ 0 slight $.~ 0 moderate ~ ~~.M 0 moderate ~ ~~.M 0 high rEJ~H. Why? 0 high rEJ~H. Why? Slight = o o o Moderate = o o o High = o o o o small quantities used per day (e.g., up to a few milliliters or grams) ( ~~~ii~~1Nj> , ~~PlJL1' ml or g ) not used for much of day or only on occasional days l ' ~ ~ ~ ~~ti~!Ir.~~1~~ tifM! If ventilation is good, may use more material or more frequently ( ~D ~~~~~~,~ii~~~~~~~~) more than "small quantities" used per day, but less than "large quantities" ( ~~~ii~~t~" 1Nj>" ~~ , 1!!1'~1N~ ) Used for at least part of day on up to a few days per week ( ~j>~ ~*~5:r~~ii , ~~~~~iiJL~ ) Ventilation is fair to good ( ~~~~ -~~~~1N~T ) Used for most of the day for most days per week ( ~~*~~ItF S ~**~5:rB11B]~ii ) Used in liter or more or kilogram or more quantities ( ~~ti~9!~~ PI 1 1t~ 1 %j..~...t ) Used with no to poor ventilation ( )9:~~~~~/~)5t~ ) A lot of skin contact happened.(~*~~&n~ti~9!) 11 SH ELL-MCCLU RG-054328