Document O3VjMnQJLREq9K5vkOyemZVzp

Monfarto 0*1 c JI C I m r n inci TO W . R. Richard - T3A September 7, 1971 POLYCHLORINATED BIPHENYLS RESEARCH SUMMARY John Mason - B2SA 1 S. Bergen L. Gossage E. Keller W. B. Papageorge C. Paton E. S. Tucker E. P. Wheeler - B2SH - 17.60? - A2SA| Summary for discussion on PCB's with FDA: 1. Chlorinated biphenyls are biodegradable. (Aroclor 1272 may not be, but this is not in production.) 2. Lower chlorinated biphenyls degrade Paster than more highly chlorinated biphenyls (Aroclor 1221 faster than Aroclor 125*1 and Aroclor 1260). * 5. Measurements of degradation: Activated sludge - bacteria, aerobic degradation Feeding study in rats Feeding study in dogs (latter tissue analysis 10# complete) 4. Correlations of toxicity in rats with chlorinated biphenyl residue in tissue. Aroclor 1260 and Aroclor 1254 - at 100 ppm in rats showed one effect - enlarged liver. PCB build-up was-bOO'to -1000 ppm in lipid. r< T b u j * A ' ^ 7 V e>r (~> Cc V-r' v t1 ; Aroclor 125*1 and Aroclor 1260 at 1 and 10 ppm, and Aroclor 1242 at 1, 10 and 100 ppm in rats showed no effect. The chlorinated biphenyl build-up was -- 250 ppm in lipid. ?^ \- 5. New Products Reduce the chlorination level - cut off Cls's or higher isomers. Maximize the rate of biodegradation. Aroclor 1016 replaces Aroclor 1242 in capacitors. to (Id W. R. Richard /is N IO M l V I I # * PLAINTIFF'S EXHIBIT _ iS 4 S ME V 0 2 6 9 ^ 6 740201