Document O35dmBe705BnjvLXGLd8LRD9K

Sf " ' ^ ~ e J.* a ' t> C IA T F ,D "E T H Y L C O M P A N t L IM IT E D '. * Jiea iste rejO ffice: TUB AD EtPH I, XOITDOlii'W0. 2 < & - & ? & * '. ' :' ' < . . _v :- . ,, , *\ ,/;/ *.***?, - *x^'c' -?"?**''" ' -: ' tEMress a ll 'cotnmunuzttums u n tilJu fth er notice &W 4~ ' ? RTILLERY HOUSE, ARTILLERY ROTO LOJiDO^ SAVT1 - KPPgfpjititVi*''--!--.''ly.,>^A^0rt&-;ABBEYS97-*-T. . V -/> -S-'^' yLPQPT:i SO^i eSTj tONDOW'iV^ : ."v\ ._. * ' '- T i '* ' - :- V jw'.i*': . v j f . - v^'.T'"! -w .. >.." _ ^ -.-* '*Sf-c*lWig2W2R5g(VararSjOv;^;>!Nw';.(-g'l-i.(.U*.';-AW>$..A)'t'.Jm'-..cETR<AtJ..o...WUERBr...s..SSASAOEI.UNBUL'QGE.BI.VLEKREAREYvTfSS*'OS.'iLNf:lCsRi*at(UN->XCCvXtoJ*W.W-CI'fR"*}L:A'vH-O*) _*i7. r. ;, f_ - , -> . . * 'VrT' *'* . -' OURREP.' 0/l . . .- - . : - ' . 30th'May,, -1944. D r. R o b ert A. K shoe, - : -. . 1 - . r - ' College of M edicine, ' - 1 '-? - ',i l U n iv e rs ity of C in c in n a ti, Ohio, U.S^A. ^ % -V? - Dear Bob,. *'< . * .i g s - 'U s ^ " -Mt * v Sjj - I a tta c h an e x tra c t from a l e t t e r received th is morning from C a sse lls w hich, I th in k , : you w ill find of in te re s t. In rgply I have to ld C assells t h a t in my o p in io n , amongst th e p a r t i e s he m e n tio n s, th e only one lik e ly to sponsor such an in v e stig a tio n is o u rs e lv e s ? and w h ils t we would be e x tre m e ly g la d t o do so, I doubt our a b i l i t y to fin d th e s ta f f o r co-operation a t the present tim e. , . : I have suggested th a t C assells give th is m a tte r some f u r t h e r th o u g h t, and i f he has any id e a s , .1 s h a l l be g la d to t a l k them over w ith him when n e x t we m eet. 1 ' ' . r i M -} * iiw 8 a a ^ liess they ir a a i ths? insidered a ll the _ * *>3i d purpose can be serv ed '^jSSKai analysis of urine or c : - - - ;.... ' W ith - a ll d i e s t ^ i s h e s , t h i s kin d and i t seems .. S incfcrjelsl.^d u rs, .tinue to be ra is e d frem I would say th a t before A irm ail copy w ith enclosure. 'T. R. A. Bevan. th ere must be : tich cannot be ood le a d in c e r ta in ion) in the a ffe c te d . .. .. . ..... ,, : .j so f a r a s we know and d is c u s s io n of them would, th e r e f o r e , n o t ta k e u s v e ry f a r . The o p p o rtu n ity e x i s t s in t h i s co u n try a t th e p re s e n t tim e to make a m ost u s e f u l i n v e s t i g a t i o n i n t o th e ex p o su re to w hich c e r t a i n I Sf ' R 0007308 - " ' .'........ -. ... ' ' ' .. - r v W ' V .-/," : C . . . I , . . - ' , . v '. . - >' 'V . r . 0 ^ -V- ; ECTRACT FROM LETTER BY DR. CASSELLS 0 /e a /l9 4 4 ' - : ' d a te d 2 6 th May, 1944. T. R. A. Sevan, E sq . . - ... . i .? * s-. w A .' ?; ~ r ,' * . < . : ' * Dear Mr. S evan,- 1 ' . ' `v. Rr-fi>.vv ' . -r .. >. - . : - .. . A', '4: ;: :'v . V. - ... * *- . . You a sk e d f o r my comments on th e H a ifa ':c a s e s . ' - A ll th a t I can u s e f u lly say i s that'; th e y may be .bases o f~ le a d -p o iso n in g although one h e s it a te s t o blame 80 octane f u e l (u n le ss th e y drank th e s tu f f ) . I imagine th a t th e doctors on th e spot considered a l l the a lte r n a tiv e s in clu d in g p e lla g ra fo r example and no purpose can be served by. em barking now upon a d i f f e r e n t i a l d ia g n o s is . The param ount need o f a c c u r a te a n a ly s is o f u r in e o r blood i s em phasised by th e afte rm a th o f c a se s of t h i s kind and i t seems to me t h a t th e bogey of T .S .L . p o is o n in g M i l c o n tin u e t o be r a i s e d from tim e to tim e u n t i l such a n a ly s is i s c a rrie d o u t. I would say th a t b efo re a case can be c la sse d as one o f T.E.L. poisoning th e re must be : - a) a degree of exposure to T.E.L. which cannot be g ain said and b) high u rin a ry lead fig u re s (o r blood lead in c e rta in ra re cases of abnormal kidney fu n ctio n ) in the a ffe c te d personnel. . . ^ ' v. Both th e s e c r i t e r i a a re a b s e n t i n th e H a ifa c a s e s so f a r a s we know and d is c u s s io n of them w ould, th e r e f o r e , n o t ta k e u s v e ry f a r . . . The o p p o rtu n ity e x i s t s in t h i s c o u n try a t th e p re s e n t . tim e to make a m ost u s e f u l i n v e s t i g a t i o n in to th e ex p o su re to w hich c e r t a i n - 0:007309 N 7853.01 ' . E x tract front C assells* l e t t e r dated 26. 5. 44. V .. page 2. . w orkers w ith a v i a t i o n and o t h e r . f u e l s a re open - c a n f i l l e r s , pumpmen, ta n k ,d ip p e rs, f i l l e r s of r a i l tan k s, road tan k s, ta rg e s e tc . to say nothing of c a rb u re tto r te s t e r s , ta n k -c lea n e rs and th e lik e . I t would, of c o u rse, be a w hole-tim e--occupation'f o r .a team-of. in v e s tig a to rs , and I th in k i t is a p ity ; ' ' -...... -r'-- f :- p t h a t th .e; ' o.-p p,o r tu n ity i s ^;n o t s e i z e?d.*.,*.?..y.< Nor one know s'w;hat. th e expo-.'sV-u\re"f,-.*o\f" suc,h ' ...... , .; ; . . -. ` .' - VH p - ' ^ ."-'V ' r - people amounts to , and..the-knowledge would help, c o n sid e ra b ly in th e d isc u ssio n . o f th e c a s e s w hich a r i s e . *' i - . . - . . . .. ' Whose f u n c tio n i t i s to sp o n so r such an i n v e s t i g a t i o n i s n o t f o r me to sa y . The i n t e r e s t e d p a r t i e s w ould seem to be th e P e tro le u m Companies, th e F a c to ry I n s p e c to r a te , th e Armed F o r c e s ' M edical S e rv ic e s a s w e ll a s A ssociated E th y l, and c e r ta in ly the c o -o p e ratio n of a l l of th e se would be a p rim a ry n e c e s s i t y i f any i n v e s t i g a t i o n w ere to be w o rth w h ile . The M edical R esearch Council might be in te re s te d as w e ll. I s h a ll be v ery in te re s te d to h ear K ehoe's views and perhaps you w i l l c o n s id e r l e t t i n g me know i n due co u rse what he h as t o say . As re g a rd s more d e t a i l e d comment, th e F e r h a ll- Z a n a r d i method o f le a d a n a ly s is cannot be d e lic a te enough i f i t showed absence of le a d in th e u rin a ry sam ples. I have not been ab le to fin d out what th e method i s . I su sp ect th a t " F e rh a ll" should be " F a ir h a ll" . With reg ard to V itam in C, re c e n t work by Kehoe and Machle (1943) has n o t confirm ed th e work o f Holmes and th e form er c o n s id e r t h a t a s c o rb ic a c id ( V it. C) h a s no a c tio n i n m in im isin g th e e f f e c t s of lead absorption. . I had a l e t t e r from Kehoe announcing h is s a fe r e tu r n and he m entioned th e pam phlet w hich you s e n t me. He p ro m ises me some d a ta w ith /<?; 0 3 0 '?3 *0 V \ ~ . ....... C i -A' . ..''.C - <'* A ` ' c z j . ' XX&ej&x ~;;c`Ai j uCjpiS, ; ': ' ,' ' " . . " ; ' . . ' i : < C ; . ' : V i . c . V. V_>\ .- * Js -v W .............. cv-U V: A : ;:S&:L ^: y : ... }. ' . '-'' '7 --Uc t 7 u.; A re n x u - n x x o ;v.u: a l 6 7 'I z t d J o i .:u: i...\u:. l u i ; ;U: . . x'M.eAxu .' ' t-'-v'u.iu , nj..o'i , oXitr i I m u l o u ' u s i l i l {.sxnrfil; X i n r i . 'A C v'"- *'- '" C l Aux c r e n s -j Ij-- ^ `xt- ;.'uxX ; -i o r &riyc'i a O . X: ' -; J- -.i n t e r e s t i n g . i n t e r p r e t a t i n o t h e r o f .a o lt^ w s -a;'vi'y '-'g a t^ ie a s u rf? ...... m e t i n g him a n d c l- a r a -g la d - th a t- h w a s ^ f i s f i d - - w ith ith e -D o d d s A c a s s e lls - m d ical s u p e r v is io n . I s h a l l 1hope t o re n e w 'a c q u a in ta n c e scime'ctim e . "r. : ./.ri J . leu; i xi f . ' i x utauA With k ind re g a rd s , ; r,;i x. t . xxv o si: J .f .u uX! u; ,u`C - uc .. . " ' Yours s in c e re ly , 7-0:. EU'X' :[ Lvi r ;-.i A.. Xj ' ' ' (SIGrED) ; 'DAVID A .'K .' CSSLLS." c J f > 77o:x: 77 ' ` . i ; : . t ' 0 - o o i.j,i s..:u.uy ..L'.UX e.; c ;.(' ;r v j x -rr:i: 'rjx :. 'A v l .7 . 7 :h :-.c: . v . : J: .;r :Y.c n e . .7 ' *:?; . -i 7 " 7 6 --7 ' : d .'u L'ir.i Xiora/oO : : 7 . c.-c: n i '`;'.ov C d l l C r ' l ........."' " ' ' 0-7 ci.: ..:I f,A -i. ;>. .'.eu ;:ip r i vax:. 77 Xiuit.C 7id.i<:.;ou 111; /'d '/d V ;; . A :.:x 0'^ O ij A'O0 : i . s j pfc Oji. ' ,1 l o : ;''CUii': .:;' r<y, X .d i 11. . , Ut o i i j c n r-ifr1. d i . 1'. i -.v- h f i i o d i';*XiV' Ci' '.'V.' - ( ^ - . - . iV . C.7 i- Ci.; , i i J l , .t .iiLx 7-Q CiU . . / i l i l :- .:. C: . Si x, ' .aelcjcjjs jilui.' : -i.,,. ,/ j .. J j : ra' n i ao &r , r : en -cri (C AciiVj- t i u A - o l c a o t a n . r>-' !u- g m m m a f : ; 'i- . ' A 7 ' V xioii^pedi' ;,. --.'A.-.'' - - xras& i.rOVx d 'ABxi XX. X d i :voi