Document O1XV8RLJg0mrDOmza3v5qp9Z1

Industrial Hygiene Digest INDUSTRIAL HEALTH NEWS LITERATURE ABSTRACTS MEDICAL ENGINEERING CHEMICAL TOXICOLOGICAL LEGAL.. daciaiona and tranda MAY, 1983 (Vol. 17, No. 8) INDUSTRIAL HYGIENE FOUNDATIONL MELLON INSTITUTE 4400 FIFTH AVENUE ,PITTSBURGH 13 PA. I PLAINTIFF'S Iv. EXHIBIT PLAINTIFFS , EXHIBIT 000^3 IAL HYOHNI wUhdatio^_ FOUNDATION FACTS Foundation Fact* la a monthly newa-lottor laauod to Industrial ooncarns holding membership In Industrial Hygiene Foundation. The Foundation is a nonprofit association of Industries for the advancement of healthful working conditions. Volume 15 May, 1953 t-qTtC^ PREPARATIONS FOR ANNUA if MEEfl&A95? No. 5 The Board of Trustees of Industrial Hygiene Fajmda^i^g'j^f Yale Club in New York on May 27. One of the major iteii^odslaiSifl: program for the Annual Meeting. The various Committees are also meeting this month to shape up plans for the Conferences to be held on November 18. The Medical Committee met in Chicago on May 6. The Chemical-Toxicological Committee has scheduled a meeting for May 20 at Mellon Institute. The Legal Committee will meet in New York on May 26. A number of suggestions have already been received for the Engineering Conference thatwill.be given attention at a later date. DR. HUSSEY DIES Dr. Raymond Hussey, Scientific Director of the Council on Industrial Health o' the American Medical Association, Chicago, died on Aoril 15. Dr, Husseywasa member of the Medical Committee of Industrial Hygiene Foundation from i$42 to ... . -- - . 4952 and of the Foundation's Air Pollution Control Committed since its formation iaV 1950. ; < / NOISE PROBLEM DISCUSSED . : ' .. : `v. .v -` . > . r . --v.'.iw;,*>- v \ Dr. Walmer presented a paper on "'The Need for a Center .for Coordinating \ ' jData on Noise (Historical Background and the Legal Problem)" at the lndustrial ^ Health Conference in Los Angeles, Calif,\4 which was held from April 18 to;25. Dr. - < IWdmer's presentation was a part of the Symposium on Ndise, jointly sponsored 'by thelndustrial Medical Association and th^e American Industrial Hygiene AssoclationV held on April 22 , The paper was published in the May issue of Industrial Medicine , T and Surgery and reprints will soon be available. > NEW REPRINTS ' Reprints of a paper on "Noise, Its Effects and Costs" by Sam L. Hooper (Remington Rand, Inc.j Past President, National Noise Abatement Council) are available on request. The paper was presented at the 17th Annual Meeting of Ind ustrial Hygiene Foundation on November 19, 1952. Also available are reprints of another paper given at the meeting on "Review of Latest Developments in Outdoor Air Pollution. " The paper is under the author ship of W. C. L. Hemeon, Engineering Director of the Foundation. filAC HYOIENE FOUNDATION I-H-F 4400 FIFTH AVENUE 'V FITTMUROH (). FA. j04 A Critical Review of the Chemical Theory of Silicosis. Luise Holzapfel. geitr. Silikose-Forsch. No. 15, 1-19 (1952) German. The solubility theory is first reviewed and reasons are given why it cannot be maintained in its original form, which says that silicosis is due to dissolved silica. The main argument is that silicosis requires years to develop, while the solubility of quartz drops in the course of days or weeks. A modi fied solubility theory is suggested by the author's published work and on her recent results with carbohydrates. From plant extracts, a fraction containing carbohydrate and silica could be isolated, and experiments with blood and quartz showed specific adsorption of a galactose complex. The galactose adsorbed on quartz still reacts with hydrazine, demonstrating that the aldehyde group does not take part in the reaction with quartz. Next follows a very speculative chapter dealing with the structure of silica-galactose complexes. Collagen is said to contain galactose but there is no evidence on its structure. The osazone reaction can be used to demonstrate quartz in human silicotic lesions, as well as to demonstrate galactose adsorption on quartz, and a number of colored illustrations of this effect are shown. Electron micrographs of serpentine asbestos after disintegration in water are also shown. -- Cond. from Bull. Hyg. 495 Considerations on a Case of Progressive Massive Silicosis Following Past Limited Exposure. M. Bodo and L. Briccarello. Rass. med. ind. 21, 233-238 (May-June 1952) Italian. The authors discuss a case of progressive massive silicosis of the lungs which was seen by them in April, 1951. The patient was a metal work er, aged 28, who had been employed, 'for 2 years only, at chiseling grindstones in 1939-40. Signs and symptoms of silicosis, which are described, appeared in November, 1950. At the time of the examination, signs and symptoms were said to be stationary. ^Tuberculosis was absent. X-rays showed a generalized deep and confluent shadow on the lungs, except for clear areas which may have been due to spontaneous pneumothorax or to localized emphysema. In the light of this case the authors question the statement that simple pneumoconiosis can be arrested by removing the patient from exposure to dust. The tendency to progress varies with the physico-chemical properties of the dust and the individual tissue reactivity. As in the case of hepatic cirrhosis, the causative agent may start a chain reaction which does not stop progressing after the cause has been removed. -- Cond. from Bull. Hyg. 496 Usefulness of the Photoroentgen Method in Silicosis and Asbestosis Investi gations of Workers. E. Zanetti. Rass. med. ind. 21_, 130-132 (1952) Italian. A comparative study of several tens of thousands of photoroentgen films and roentgenograms has produced several interesting conclusions con cerning investigations of silicosis and asbestosis among workers. 35 mm. photoroentgen films were found to represent clearly massive silicosis, advanced Industrial Hygiene Digest - 22 May, iVSi asbestosis, and nodular silicosis. In silicosis which is represented by reti- culation.identification is more difficult, but it is still possible in the hands of an'expert. The identification of mild or moderate asbestosis is still more difficult. Only a great deal of.experience which is integrated with a knowledge of concentrations and exposures of the dust involved makes possible an intel ligent interpretation of such films. -- Biol. Absts. ^ 497 Does Silicosis Affect the Silica Content of Human Blood? G. Worth and G. Campen. Z. physiol. Chem- (Hoppe-Seyler's) 288, 155-164 (1951). German. The authors determined the sijica content of blood of 264 persons, half of whom were coal miners with various stages of silicosis, using the molyb. denum blue technique.1 The mean result for the whole group was 8.3 + 2.4 micrograms silica per ml. of blood. Neither sex, different kinds of inflamma tory or other diseases, nor silicosis caused any difference in the silica content of the blood. Tests were also made after ingestion of organic silicon compound*. Here a rapid rise of silica content of blood and urine was found, but the blood silica had dropped to its normal value after 9 hours. The bearing of these findings on the silica solubility theory is discussed. If the theory is to be main tained, it must be assumed that the amounts dissolved are too small to be demon, .strated in the blood or that excretion through the kidneys is too rapid. - Cond, from Bull. Hyg. 498 Silicotic and Tuberculosilicotic Lesions Simulating Carcinoma.- F G. Kergin. J. Thoracic Surg. 24, 545-567 (Dec. 1952). The appearance of unilateral massive densities in the lungs of eight men between the ages of 49 and 69 with chroftic pneumonitis has been reported. In each of these patients clinical and radiogr&phic evidence strongly suggested broncHiogenic carcinoma. Five of the eight patients had prolonged exposure to silica-containing dust in various occupations. Five patients were treated hy pneumonectomy, one by lobectomy, and one by thoractomy and biopsies were made. The fundamental feature of the pathological process in this group of patients was complete or partial bronchial obstruction by pressure of lymph | nodes, which were the site of a chronic inflammatory reaction secondary to :* inhalation of silica-containing dust. In five patients the chronic obstructive pneumonitis was non-specific, and in three there was an added tuberculous jf infection.it is suggested that this condition be called "chronic silicotic lympha- f dentis with obstructive pneumonitis (nontubfrculous or tuberculous).1' The | patients are all alive; the six patients treated by excision have been relieved | of their complaints. -- Cond. from J. Am. Med. Assn.