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Nr. S.D. Klrsoh Borden-Arabol Co. 103 Footer street Pmbody, Nsssaohusetts 01960 Our Rr. w.S. Clerk has lnfonaed at that you are doolroua of obtaining toxlolty data for Aroolor 1291 and Aroolor 3460. Tho data that are available for these two product* are aa follows 1 Aroolor 1221 Acute Oral Iftm - Rat - Undiluted seaple - 3980 ag/kg. the saapie wasaXaaaed aa slightly toxic. Acute Nlnlaal Lethal SoM - Skin Absorption - Rabbit - Clipped Intact Skin - Oreaterthan 2000 but less than 3160 ag/kg The seaple was cleased aa slightly tootle. Subacute flltln Absorption - Dally application for 20 days of a 12.9P solution ln oorn oil at 190 M/kg/day - No untoward reactions 200 ag/kg/day - Weakness, lassitude, and loss of appetite 500 ag/kg/day - " " " there were no dMthe and the haaatologlo studies and urine analyses at all doae levels were oeaparable to the oontrols. Oross and aloropatholegle findings In the sacrificed test anlaals revealed no algalfleant dlfferenee fraa that of the oontrols. this la all of the lnfonmtion we have on Aroolor 1221. we would reecaaend as a aatter of good practice aeohanloal exhaust ventilation if the aater&al la to bo used at elevated teaperaturee. Aroolor 5460 this produot appoars to bo quite Inert physiologically. the oral Uan in rata was found to bo 19,200 ag/kg and rabbit* survived does* up w 7,940 when applied to the ekin. in both eases the seapl* was tested aa e 3311/30 solution-suspension in 00m oil. In 90-day MQNS 087909 2 oral studios In rats, thora were no sdvorso offsets froa Aroelor 5^60 when It hob Incorporated In the diet at 100 and 300 ppm. In leghorn chickens, 500 ppn in tho dlot shoved no offoot except slightly reduced site of growth In the study of 18 weeks. Based on the anlnal toxicity studies and the physleal characteristics. It would not appear that the use of this product should introduce any serious hanrds. Me would recommend as a natter of good practice aeohanloal exhaust ventilation If the Material Is to be used at temperatures where it would be molten. Sincerely yours Mllllan H. Hunt, Ph.D, Toxicologist Nedloal Sopartaent W.8. Clark - St. Louis MONS 087910