Document Ny8pZa3BoXZy7rxrNXaOpjxg

I P2140542 a###*###*#*#*####*****###**#*##**#***#****##***##***#******#*#####*#***# ** * THIS IS AH OFF-LINE BIBLIOGRAPHIC CITATION LIST GENERATED BY * ** * MEDLARS II * K* * N.L.M.'S NATIONAL INTERACTIVE RETRIEVAL SERVICE * * ************************************************************************** VCM NUMBER OF CITATIONS PRINTED = 299 THIS SEARCH WAS PERFORMED ON THE T0XLIT65 SORT WAS NOT REQUESTED REQUESTED BY R.N. WHEELER AUGUST 23, 1989 FILE. PLEASE SEND THIS LISTING TO TIMOTHY J CAWLEY, UNION CARBIDE CORP. 39 OLD RIDGEBURY RD. P2-585 DANBURY, CT 06817-0001 m m RNW 1595 00009931 VCM PAGE 1 1 SI - CA/097/027797E CC - CA/159000 AU - Dodic S TI - Vinyl chloride and its polymer as a new potential pathogenic factor in modern illness SO - Med. Podmladak; VOL 32, ISS 1, 1980,67-9 PT - JOURNAL ARTICLE CY - Yugoslavia LA - SCR CD - MPODA IS - 0369-1527 AB - CBAC COPYRIGHT: CHEM ABS Review vinyl chloride occupational hazard Cancer vinyl chloride manuf review PVC manuf occupational hazard review Disease occupational PVC chloroethene review;Disease In vinyl chloride and poly(vinyl chloride) manufg. workers, in Yugoslavia OccupationaljNeoplasm In vinyl chloride and poly(vinyl chloride) manufg. workers, in Yugoslavia RN - 75-01-4; 9002-86-2 EM - 8208 2 SI - CA/096/175526K CC - CA/104003 AU - Kogai AM ; Stepanenko AF 5 Dubinskaya AB ; Kachkina GV TI - Toxicological characteristics of vinyl chloride dusts of MA-20 and A-150M copolymers SO - Vliyanie Khim. Faktorov Vnesh. Sredy na Zdorov'e Cheloveka, Rostov N/D; 1980,98-100 PT - JOURNAL ARTICLE CY - USSR LA - RUS CD - D3RAP AB - CBAC COPYRIGHT: CHEM ABS Title only translated. Vinyl chloride copolymer dust air Pollution air vinyl chloride copolymer MA 20 dust air pollution A 150M dust air pollution RN - 75-01-45 25035-98-7; 81627-77-2 EM - 8206 3 SI - CA/096/099133N CC - CA/104006 AU - Maltoni C ; Lefemine G ; Ciliberti A 5 Cotti G ; Carretti D AD - Inst. Oncol. Tumour Cent., Bologna TI - Vinyl chloride carcinogenicity bioassays (BT project) as an experimental model for risk identification and assessment in environmental and occupational carcinogenesis SO - Epidemiol. Anim. Epidemiol. Hum.: Cas Chlorure Vinyle Monomere, [Reun. Club Cancerog. Chim.], 20th; 1980,11-112 PT - MONOGRAPH CY - Italy LA - ENG/FR CD - 46XZA AB - CBAC COPYRIGHT: CHEM ABS Tumors were induced in rats following long-ter.-,i exposure to 14 doses of vinyl chloride (I) [75-01-4] RNW 1596 00009932 VCM PAGE 2 (from 1 to 30>000 ppm) by inhalation and to 6 doses of I (from 0.03 to 50 mg/hg) by ingestion. Risk identification and assessment in environmental and occupational carcinogenesis are discussed. RN - 75-01-4 EM - 8205 4 SI - CA/096/073831P CC - CA/159001 AU - Shpak LI > Kirsanova AI 5 Derbenev VV TI - Determination of vinyl chloride in polymer dusts and in air by gas-liquid chromatography applicable to toxicological studies SO - Vliyanie Khim. Faktorov Vnesh. Sredy na Zdorov'e Cheloveka, Rostov N/D; 1980,101-3 PT - JOURNAL ARTICLE CY - USSR LA - RUS CD - D3RAP AB - CBAC COPYRIGHT: CHEM ABS Vinyl chloride detn air dust Polymer dust vinyl chloride detn Toxicol vinyl chloride detnIAir analysis Vinyl chloride detn. in, gas chromatog. in, toxicol. in relation toJDust Vinyl chloride detn. In, gas chromatog. in, toxicol. in relation to Polymer;Polymers Vinyl chloride detn. in, gas chromatog. in, toxicol. in relation to Dust RN - 75-01-4 EM - 8204 5 SI - CA/094/196914J AU - Antonyuzhenko VA TI - (Occupational) Vinyl Chloride Disease - Hydrocarbon Neurotoxicosis SO - 1980,183 pp. LA - RUS CD - BOOKA AB - CBAC COPYRIGHT: CHEM ABS ADDENDUM A book. Book vinyl chloride neurotoxicosis Safety neurotoxicosis vinyl chloride book RN - 75-01-4 EM - 8110 6 SI - CA/094/151415F AU - Gaylor DW ; Kodell RL AD - Div. Bicrn., Natl. Cent. Toxicol. Res., Jefferson TI - Linear interpolation algorithm for low dose risk assessment of toxic substances SO - J. Environ. Pathol. Toxicol.; VOL 4, ISS 5-6, 1980,305-12 LA - ENG CD - JEPTD AB - CBAC COPYRIGHT: CHEM ABS ADDENDUM In order to detect potential toxic effects of substances, relatively high doses generally are administered to relatively small nos. of lab. animals. It is impossible to est. low levels of disease incidence with precision at low environmental dose levels even with large nos. of lab. animals. However, upper limits on risk can be obtained for convex dose-response curves by linear interpolation between the RNW 1597 00009933 VCM PAGE 3 lowest exptl. dose level and zero. A simple math, algorithm is provided for low-dose risk assessment from dose-response data and the performance of this procedure is evaluated for a variety of toxicol. data, including but not limited to carcinogenesis. The low-dose confidence limits resulting from linear interpolation are similar to those obtained from the Armitage-Doll multistage model (1961). RN - 50-29-3; 60-57-1J 62-75-9; 75-01-4; 96-45-7; 118-74-1; 128-44-9; 139-13-9; 542-88-15 828-00-2; 1162-65-8; 1746-01-6 EM - 8110 7 SI - CA/094/144806F AU - Stonebraker RD 5 Smith AJ Jr AD - Environ. Emergency Branch, U. S. Environ. Prot. Agency, Atlanta TI - Containment and treatment of a mixed chemical discharge from the "Valley of the Drums" near Louisville, Kentucky SO - Control Hazard. Mater. Spills, Proc. Natl. Conf.; 1980,1-10 LA - ENG CD - 44FUA AB - CBAC COPYRIGHT.* CHEM ABS ADDENDUM Emergency measures taken to contain and treat surface run-off from a hazardous waste dump site near' Louisville, Kentucky, are described, including the construction of intercept trenches, a catchment basin, and an activated C adsorption unit preceded by an aeration and pH adjustment chamber. RN - 65-85-0; 67-64-15 71-36-3; 71-43-2*, 75-01-4; 75-09-2; 75-34-3; 75-84-35 76-22-2*, 78-59-1*. 78-83-1*, 78-93-3*, 83-32-9; 84-66-2*, 84-74-2; 85-01-8; 86-73-7; 87-86-5; 88-99-3; 91-20-3; 91-22-5; 95-13-6*, 98-55-5*, 98-85-1; 100-41-4*, 100-42-55 101-84-8*, 108-10-15 108-88-35 108-93-0*, 108-94-1J 108-95-2*, 109-52-4; 110-54-35 111-27-3; 111-76-25 112-34-5', 112-49-2*, 117-81-7; 120-12-7? 122-60-15 126-73-8; 129-00-0*, 131-11-3', 132-64-9; 142-62-1*, 142-96-15 143-24-85 149-57-55 156-60-55 206-44-0*, 409-02-9J 501-52-0*, 613-46-7; 617-94-7*, 624-92-05 626-93-7*, 816-19-35 665-66-7*. 1300-71-65 1319-73-9; 1319-77-35 1321-94-4? 1330-20-7? 1333-07-9*. 1907-65-9? 3073-92-5*, 8013-00-15 25322-20-7? 25323-89-1; 25567-10-6*, 26523-64-85 26638-03-9; 29299-43-2', 29387-86-85 35915-22-1? 50874-76-5*. 53535-33-4*, 54518-04-6? 54972-97-3? 77110-32-8*. 77110-33-9? 77110-34-0? 77110-35-1? 77110-36-2? 77110-37-3? 77110-38-4? 77110-39-5*, 110-93-0; 815-24-7 EM - 8110 8 SI - CA/093/126429K AU - Bolt HM ? Filser JG ? Laib RJ *, Ottenwaelder H AD - Inst. Toxikol., Univ. Tuebingen, Tuebingen TI - Binding kinetics of vinyl chloride and vinyl bromide at very low doses SO - Arch. Toxicol., Suppl.5 VOL 3, ISS Quant. Aspects Risk Assess. Chem. Careinog, 1980,129-42 LA - ENG CD - ATSUD AB - CBAC COPYRIGHT: CHEM ABS A review and discussion with 55 refs. RNW 1598 00009934 VCM PAGE 4 on the mechanism and kinetics of hepatic covalent protein binding of vinyl chloride and vinyl bromide. (75-01-4 Vinyl chlorideH593-60-2 Vinyl bromide) RN - 75-01-45 593-60-2 EM - 8010 9 SI - CA/093/080083N AU - Igarashi T ; Inai Y ; Kijima S > Nakajima Y Yamatsu I TI - Treating hypertension with polyprenyl alcohol ester SO - U.S. PATENT NO. 4199587 04/22/80 (Eisai Co., Ltd.) LA - ENG AB - CBAC COPYRIGHT: CHEM ABS ADDENDUM Polyprenyl esters H(CH2CMe:CHCH2)n02CR, where n = 8-11, R = Cl-17 satd. or unsatd. aliph. group, cyclohexyl, Ph, or substituted Ph, are prepd. and used to treat hypertension. The compds. have less toxicity and side effects than previous antihypertensives. The esters were prepd. from the corresponding polyprenols. 3.7.11.15.19.23.27.31.35.39.43-Undecamethy1-2,6,10,14,18,22,26,3034,38>42-tetracontaundeeaen-3-ol was prepd. by the Grignard reaction of vinyl chloride with decaprenylacetone. (70575-57-4 3.7.11.15.19.23.27.31.35.39.43-undecamethy1-2,6,10,14,18,22,26,3034,3842-tetracontaundecaen-3-ol)(75-01-4 Vinyl chloride )(74423-84-0 decaprenylacetone ) Pharmaceutical compns . were prepd. contg. 3,7,11,15,19,23,27,31,35-nonamet hy1-2,6,10,14,18,22,26,30,34-hexacontanonaenyl 2-(p-chlorcphenoxy)-tert-butyrate. (74423-81-7 3,7,11,15,19,23,27,31,35-nonamet hy1-2,6,10,14,18,22,26,30,34-hexacontanonaenvl 2-(p-chlorophenoxy )-tert-butyrate) RN - 70575-57-45 75-01-4; 74423-84-0*, 74423-81-7', 74-86-2*, 70495-51-1; 70495-52-2*, 70495-54-4*, 70495-55-5*, 70495-56-6; 70495-57-7*, 70495-58-8J 70495-59-9; 70495-60-2; 70495-61-3; 70520-55-7; 74423-82-8; 70572-86-0 EM - 8105 10 SI - CA/093/224867W AU - Jarosek K ; Jakubis M AO - Povasske Chem. Zavody, n. p. Novaky TI - Waste disposal in vinyl chloride production SO - Chem. Prum.*, VOL 30, ISS 5, 1980,256-7 LA - SLO CD - CHPUA AB - CBAC COPYRIGHT: CHEM ABS The most suitable disposal of waste gases contg. .ltoreq.52 (vol.) of vinyl chloride consists of absorption in C2H4C12 under moderate pressure and successive high pressure desorption of vinyl chloride from the solvent. (75-01-4 Vinyl chloride) Waste gases contg. 0 .ltoreq.5/ (vol.) are combusted in a special oven and the HCl formed is absorbed either in H20 or adsorbed by a solid sorbent. RN - 75-01-4 EM - 8101 RNW 1599 00009935 VCM PAGE 5 11 SI AU AD TI SO LA CD AB RN EM CA/093/224840G Krajewski J ; Gromiec J 5 Dobecki M Inst. Occup. Med. Lodz Comparison of methods for determination of desorption efficiencies Am. Ind. Hyg. Assoc. J.; VOL 41, ISS 7, 1980,531-4 ENG AIHAA CBAC COPYRIGHT: CHEM ABS Three methods for desorption efficiency detn. were compared with a ref. dynamic method for 12 compds. Only 1 of them gave values that were statistically different. The method, in which std. solns. of detd. compds. in CS2 are injected onto charcoal, is recommended to all labs, dealing with air anal, as it is simpler than the dynamic method. Independence of the desorption efficiency on charcoal loading was also confirmed. The desorption efficiencies for individual compds. and their mixts. were found to be different. 56-23-5; 67-64-1; 67-66-35 71-36-3; 71-43-25 75-01-45 75-09-25 108-05-45 108-88-35 108-94-15 141-32-25 141-78-6 8101 12 SI - CA/093/209565C AU - Drugov YS 5 Murav'eva GV 5 Letunovskaya GA TI - Quantitative determination of vinyl chloride impurities in air SO - U.S.S.R. PATENT NO. 728081 04/15/80 (Leningrad Scientific-Research Institute of Industrial Hygiene and Occupational Diseases) LA - RUS AB - CBAC COPYRIGHT: CHEM ABS Vinyl chloride is detd. in air by concn. on activated C, elution with an org. solvent, and chromatog. of the eluate. (75-01-4 Vinyl chloride) The precision and selectivity of the detn. are increased by passing the sample through a column filled with mol. sieves and etched glass fiber before anal. RN - 75-01-4 EM - 8012 13 SI - CA/093/209402X AU - Vanko A 5 Lukacovic L 5 Kiss G 5 Mikulas M AD - Vysk. Ustav Petrochem., Novaky TI - Problems in measurement of gaseous industrial air pollution by gas chromatography SO - Chem. Prum.5 VOL 30, ISS 5, 1980,253-6 LA - SLO CD - CHPUA AB - CBAC COPYRIGHT: CHEM ABS Special precautions needed for adapting conventional GC procedures for the detn. of trace components in worksite air are discussed, e.g. the problem of loss by sorption and/or condensation of the component on the walls of the sampling vessel, connecting tubing, injection syringe, etc., and the necessity for thorough flushing of the app. after calibration tests with std. samples of higher concns. For traces of vinyl chloride in air the flame ionization detector RNW 1600 00009936 VCM PAGE 6 was preferred because of its selectivity and high sensitivity for org. compds. (75-01-4 Vinyl chloride) For the spectrum of inorg. gases from oxidn. processes the thermocond. detector was satisfactory. RN - 75-01-4 EM - 8012 14 SI - CA/093/198688S AU - Slushchenko VI ; Fomenko VN 5 Pavlenko GI ; Semiletkina NN AU - Grodetskaya NS 5 Pankratova GP 5 Vorontsov RS 5 Gracheva KM AD - Inst. Gig. Tr. Profzabol.* Moscow TI - Chronic experimental toxicity of vinyl chloride SO - Gig. Tr. Prof. Zabol.5 ISS 9, 1980>44-6 LA - RUS CD - GTPZA AB - CBAC COPYRIGHT: CHEM ABS Rats exposed to 35.3 mg vinyl chloride/m3 in chronic expts. showed increased body wt.> changes in carbohydrate metab. with reduced activity of the insulin app.> increased no. of leukocytes> increased protein and chloride in the urine and reduced diuresis. (75-01-4 Vinyl chloride) Similar changes were seen at a concn. of 4.8 mg/m3. The cardiovascular system showed phasic changes. The histol. of the organs showed practically no changes at the lower concn. The nervous system was affected at the higher concn. The new recommended max. permissible concn. of vinyl chloride is 0.1-0.5 mg/m3. RN - 75-01-4; 16887-00-6 EM - 8012 15 SI - CA/0 93/a 7 3-626G TI - Musk substitute SO - Jpn. tckk-o Koho PATENT NO. 80 12408 04/02/80 (Takasago Perfumery Co. > L~ c . ) LA - JPN AB - CBAC CCK sRIGHT: CHEM ABS Cyclohexadec-5-enone (I)> a musk perfuv. e substitute* was prepd. (37609-25-9 Cyclohexadec-5-enone) Thus > C :guard reaction of cyclododecane epoxide with H2C:CHC1 gave 3?:: II (X = H> OH) which was oxidised by Jones reagent to give 69" II (X = 0)> followed by a further Grignard reaction with H2C:CHCi to give 95X II (X = CH:CH2> OH). (286-99-7 Cyclododecane epoxide)(75-01-4 Vinyl chloride) Air oxidn. of the latter 3 h at 210-20.degree. gave I. RN - 37609-25-9? 286-99-7; 75-01-4; 37609-22-65 37609-23-75 35951-27-05 123-69-35 541-91-35 542-46-1 EM - 8011 RNW 1601 00009937 VCM PAGE 7 16 SI - CA/093/161913K AU - Hopkins J AD - BIBRA TI - Vinyl chloride. Part 5. Mutagenicity in man SO - Food Cosmet. Toxicol.; VOL 18, ISS 2, 1980,200-1 LA - ENG CD - FCTXA AB - CBAC COPYRIGHT: CHEM ABS A review with .apprx.12 refs, on the mutagenicity of vinyl chloride in man. (75-01-4 Vinyl chloride) RN - 75-01-4 EM - 8011 17 SI - CA/093/155061Q AU - Allen TL 5 MacNab JR *, Jefferis RP II AD - Stauffer Chem. Co., Delaware City TI - VCM concentration in ambient air measurement using computer-controlled gas chromatographs SO - Anal. Instrum. *, VOL 18,, 1980,1-8 LA - ENG CD - AINSB AB - CBAC COPYRIGHT: CHEM ABS The design, implementation, and operation are described for a microcomputer system for automatically sequencing, measuring, alarming, and recording ambient air detn. for vinyl chloride from a gas chromatog. according to a sequence, which varies as alarm levels are sensed. (75-01-4 Vinyl chloride) RN - 75-01-4 EM - 8011 18 SI - CA/093/172984K TI - Recovery of halogenized vinyl compounds from waste gases SO - Jpn. Tokkyo Koho PATENT NO. 80 04729 01/31/80 (Shin-Etsu Chemical Industry Co., Ltd.) LA - JPN AB - CBAC COPYRIGHT: CHEM ABS The title compds. are recovered by sorption with activated C in 2 zones followed by thermal desorption under vacuum in the 1st zone and with steam in the 2nd zone. Thus, a waste gas (120 m3/h) contg. 12.5 wt. X vinyl chloride (I) was passed through 2 columns (at 15.degree.) contg. 1.7 and 1.3 tons activated C, resp. to give an effluent contg. an undetectable amt. of I. (75-01-4 Vinyl chloride) After 8 h of operation, the I concn. in the effluent from the 1st column increased from an initial value of 80 to 1000 ppm. The 1st column was heated (125.degree. ) under vacuum (200 mm, 2 h) and the I removed was recovered as a condensate. After 400 h, the I concn. in the effluent from the 2nd column reached .apprx.0.1 ppm; the column was heated (125.degree.), and steam (160 kg/h> 3 h) and N (1 m3/h 1 h) were circulated through it. The I emission was then controlled at <0.1 ppm. RN - 75-01-4; 7440-44-0 EM - 8011 RNW 1602 00009938 VCM PAGE 8 19 SI - CA/093/172983J TI - Recovery of vinyl or vinylidene halides from waste gases SO - Jpn. Tokkyo Koho PATENT NO. 80 04730 01/31/80 (Shin-Etsu Chemical Industry Co.* Ltd.) LA - JPN AB - CBAC COPYRIGHT^ CHEM ABS The title compds. are recovered by sorption with activated C followed by desorption with steam, hot air, or hot inert gas under vacuum. Thus, a waste gas contg. 10 wt. 7. vinvl chloride (I) was passed through a column (contg. activated C) surrounded by a water jacket. (75-01-4 vinyl chloride) Steam was then introduced into the water jacket, the pressure in the column was maintained at 100 mm, and a stream of steam (1.2 kg/cm2) was circulated through the column for 2.5 h and fed to a condenser for sepn. of I. The treated waste gases contained .ltoreq.0.05 ppm I, and the sorption capacity of the C was maintained even after 1 yr of continual operation. RN - 75-01-4; 7440-44-0 Eh - 8011 20 SI - CA/093/100826N AU - Confer RG TI - Emission control method and system SO - Can. PATENT NO. 1070641 01/29/80 (Exxon Research and Engineering Co. ) LA - ENG AB - CBAC COPYRIGHT: CHEM ABS The system consists of the decompn. chamber housing a UV light source, a gas scrubber, and an exhaust gas monitor. Thus, the stack emissions contg. vinyl chloride, NO, H2S, and CS2 enter the decompn. chamber and are exposed to the UV irradn. at the intensity 3-6 W/L of plenum vol. at 615 nm for 20-50 s. The gases are then passed through the scrubber to remove the decompn. products including HCl, phosgene, and Cl2. The monitor samples the exhaust gas from the scrubber before release to the atm. The exhaust gases are recycled through the feedback to the decompn. chamber, when the pollutants concns. are less than the predetd. levels. RN - 75-01-45 75-15-05 75-44-55 7647-01-0; 7782-50-5; 7783-06-45 10102-43-9 EM - 8009 21 SI - CA/093/100784X AU - Gnesina EA 5 Pshenitsyna AI AD - Inst. Gig. Tr. Profsabol.* Gorkiy TI - Dynamics of the frequency of cardiac contractions and galvanic skin reflex during nocturnal sleep in patients with chronic occupational vinyl chloride poisoning SO - Gig. Tr. Prof. Zabol.5 ISS 5, 1980,39-42 LA - RUS CD - GTPZA AB - CBAC COPYRIGHT: CHEM ABS The differences in the heart contraction rate (R) and the galvanic skin reflex (G) obsd. at different sleep stages of patients with vinyl chloride poisoning RNW 1603 00009939 VCM PAGE 9 were correlated with the degree of their poisoning. (75-01-4 Vinyl choride) For patient with only incipient intoxication R and G were different for the different sleep stages* but for patients with severe* chronic intoxication nearly const. R and G values (considerably lower than for the normal subjects) were obsd. RN - 75-01-4 EM - 8009 22 SI - CA/093/039112H AU - Abbondandolo A AD - Univ. Pisa* Pisa TI - Collection and evaluation of data on mutagenic effects of environmental chemicals SO - Comm. Eur. Communities* (Rep.) EUR* ISS EUR 6388* Environ. Res. Programme** 1980*670-3 LA - ENG CD - CECED AB - CBAC COPYRIGHT: CHEM ABS A format was developed for assessing the mutagenicity of environmental chems.* e.g.* Hg and Cd compds. and pesticides. The general scheme for the collection of mutagenicity data included the type of genetic effect induced by the chem. and information on the test organism. RN - 50-07-7; 50-18-05 55-18-5; 60-57-1; 62-38-4; 72-20-8; 75-01-4; 100-57-2; 107-27-7', 107-28-8; 115-09-35 123-88-65 297-78-9; 309-00-25 502-39-6J 543-90-85 671-16-9; 1184-57-2; 1306-23-65 3076-91-3*, 7439-97-65 7440-43-95 7487-94-75 7789-42-65 7790-80-9; 10045-94-0 5 10108-64-2 5 10325-94-75 17774-02-6 5 18431-36-2 EM - 8009 23 SI - CA/093/038420V AU - Pessayre D ; Wandscheer JC 5 Descatoire V ; Dolder A 5 Degott C AU - Benhamou JP AD - Unit Rech. Physicpathol. Hepatique* Hop. Beaujon* Clichy TI - Cumulative effects of repeated doses of compounds transformed into reactive metabolites SO - Bioche... Pharmacol.; VOL 29, ISS 7, 1980,1041-7 LA - ENG CD - BCPCA AB - CBAC CGPtRIGHT: CHEM ABS Rat hepatic cytochrome P-450 concns. were not decreased by single doses of bromobenzene trichloroethylene* or vinyl chloride (0.25* 1* and 0.5 mmol/kg, resp.* i.p.)* but were progressively decreased after daily administration for 3 days. (9035-51-2 cytochrome P-450)(108-86-1 Bromofcenzene )(79-01-6 Trichloroethylene)(75-01-4 Vinyl chloride) Hepatic glutathione was decreased 4 h after a single dose of bromobenzene* but it was not decreased 24 h after a single or repeated doses. (70-18-8 Glutathione) The amt. of metabolite irreversibly bound to proteins progressively increased in the liver during repeated administration of the 3 drugs. Thus, daily administration of compds. transformed into reactive metabolites may lead to a progressive decrease in cytochrome P-450 concn. and to the accumulation of metabolites irreversibly bound to proteins RNW 1604 00009940 VCM PAGE 10 in the liver. RN - 9035-51-2; 108-86-15 79-01-6; 75-01-4; 70-18-8 EM 8009 24 SI CA/095/191833T AU - Feiler HD ; Storch PJ ; Southworth R AD - Burns Roe Ind. Serv. Corp., Paramus T1 - Organics in municipal sludges survey of forty cities SO - Natl. Conf. Munic. Ind. Sludge Util. Disposal, [Pap.]; 1980,53-7 LA - ENG CD - 460UA m AB CBAC COPYRIGHT: CHEM ABS The survey is concerned with the occurrence and fate of 129 toxic inorg. and org. pollutants in wastewater treated in publicly owned treatment plants of 40 cities. Volatile toxic pollutants in the influent had a median loss of 72, base-neutral orgs. 37, and metals in the "total out" were TV. lower than the influent. RN -- 71-55-6; 75-01-45 75-09-25 79-01-6J 84-74-2; 85-68-7; 95-50-1; 100-41-45 108-88-3J 117-81-7; 127-18-45 156-60-5 m EM " 8112 25 SI _ CA/095/155659G AU - Phillips MP AD - Univ. Colorado, Boulder TI Chemical sensitization of an electron capture detector to weakly electron attaching compounds SO - Diss. Abstr. Int. B 1981, 42(1), 196; 1980,95 pp. % LA - ENG CD - DABBB AB CBAC COPYRIGHT: CHEM ABS A disser. Electron capture detector sensitization Vinyl chloride detn air chromatog Carbon monoxide % RN _ detn air 75-01-4; chromatog 630-08-0; 10024-97-2 EM - 8111 * 26 SI _ CA/095/137671A AU - Stampfer JF ; Weeks RW Jr ; Ettinger HJ AD - Los Alamos Sci. Lab., Los Alamos TI -- Respirator canister evaluation for selected organic vapors and sorbent performance against vinyl chloride SO - Report; ISS LA-8560-MS,, 1980,40 pp. # LA - ENG CD - D3REP * AB -- CBAC COPYRIGHT: CHEM ABS The protection afforded by a com. org. vapor respirator canister against CHC13, benzene, epichlorohydrin, acrylonitrile, propargyl alc. 1.2-- dibromoethane, acrolein, chloromethyl He ether, and N-nitrosodimethylamine was detd. (67-66-3 Chloroform)(71-43-2 Benzene)(106-69-8 Epichlorohydrin )(107-13-1 # Acrylonitrile)(107-19-7 Propargyl alcohol)(106-93-4 1.2- dibromoethane)(107-02-8 Acrolein)(107-30-2 Chloromethyl methyl ether)(62-75-9 N-Nitrosodimethylamine) Six canisters simultaneously were challenged at 64 L/min with test atmospheres RNW 1605 00009941 VCM PAGE 11 of thevi ds. at 80 and <152 relative humidity (RH). Breakthr'-. 3;, vol. was defined as that vol. of air which passed through ' ~ canister before the downstream concn. was 12 of the challen-t concn. Tests were continued until at least this concn. was attam-id or 16 h had elapsed* whichever occurred 1st. Under a modera.e workload* these canisters should afford adequate protection against CHC13* benzene* and acrylonitrile for at least 4 h. epichlorohydrin for at least 8 h* and the remaining compds. (except chloromethyl Me ether) for at least 16 h. Chloromethyl Me ether at 802 RH exhibited a min. penetration of 302 after only 34 min, and it appears that this and similar canisters will not provide adequate protection against atmospheres contg. this compd. charcoal and ambersorb 347 when used in respirator equipment, appear only marginally useful against vinyl chloride. (79079-33-2 ambersorb 347)(75-01-4 Vinyl chloride) RN - 67-66-3J 71-43-2; 106-89-8; 107-13-1; 107-19-75 106-93-4; 107-02-8J 107-30-25 62-75-95 79079-38-25 75-01-4 EM - 8111 27 SI - CA/095/145060R AU - Rickart R ; Appel KE 5 Schwarz M ; Stoeckle G ; Kunz M AD - Inst. Biochem., Dtsch. Krebsforschungszent.* Heidelberg TI - Correlations between primary effects of xenobiotics on liver cells in vitro and their mutagenicity and carcinogenicity in vivo SO - Short-Term Test Syst. Detect. Carcinog., (Proc. Symp.35 1980,179-89 LA - ENG CD - 450HA AB - CBAC COPYRIGHT: CHEM ABS In a dose-dependent manner dimethylnitrosamine (DMN) alkylates proteins of mouse liver microsomes pretreated with phehobarbital* halothane* or 3-methylcholanthrene (3-MC). (62-75-9 DimethyInitrosoamine) The alkvlation rates of bases in mouse liver DNA in the presence of DMN are decreased by phenobarbital and 3-MC, and increased by SKF 525A and halothane. Pretreotment of the animals with phenobarbital decreased the no. of DMN-induced DNA breaks. (50-06-6 phenobarbital) A comparison of the ability of 22 compds. including drugs and food additives to covalently bind to DNA* induce DNA breakage* induce enzyme deficiency in the liver, and their carcinogenic potential is presented. Apparently, the inital effect of a carcinogen is a mutagenic one. RN - 62-75-9; 50-06-6} 53-96-35 55-18-55 56-23-5; 58-15-15 59-89-2*, 60-11-75 75-01-4*, 151-67-75 547-57-95 915-67-35 1162-65-85 2347-72-0; 2706-28-75 2783-94-05 5632-47-35 13073-35-35 14797-65-0; 50926-81-3 EM - 8111 RNW 1606 00009942 VCM PAGE 12 28 SI AD TI SO LA CD AB RN EM CA/095/102431V Washington Principles of toxicological interactions associated with multiple chemical exposures Report*, ISS Order No. AD-A093 809,, 1980,204 pp. ENG D8REP CBAC COPYRIGHT: CHEM ABS On a typical day, a US Coast Guard inspector may enter confined spaces on as many as 5 vessels. Because each of these ships may have carried different cargoes, an inspector could be exposed to a mixt. of vapors from 5 different chems. An inspector may be exposed almost daily to benzene, various nitriles, MeOH, caustic soda, CC14 vinyl chloride, and NH3 with exposure time varying from a few minutes to 2 h. (71-43-2 Benzene)(67-56-1 Methyl alcohol)(75-01-4 Vinyl chloride) Although permissible levels (threshold limit values) have been established for these vapors and must be attained before marine personnel can enter a confined space, the Coast Guard has become increasingly concerned about the interactions that might accrue from these exposures and possibly result in deleterious health effects. A Panel on Evaluation of Hazards Assocd. with Maritime Personnel Exposed to Multiple Cargo Vapors was formed. This report is a 1st attempt to assess the added hazards, if any, to marine inspectors who are occupationally exposed to multiple chems. 71-43-2J 67-56-1*, 56-23-5; 75-01-4', 1310-73-25 7664-41-7 8110 29 SI - CA/095/048340Z AU - Pavlova LA 5 Sukharev YG 5 Boldyrev VI TI - Methods for Removal of Vinyl Chloride from Waste 6ases in PVC Production SO - 1980,12 pp. LA - RUS CD - BOOKA AB - CBAC COPYRIGHT: CHEM ABS A book. Book vinyl chloride removal gas RN - 75-01-4; 9002-86-2 EM - 8109 30 SI - CA/055/037123E AU - Kiehs K , Schwarz GU 5 Adolphi H TI - Carboxyl ^.cid esters for pest control SO - S. Afrits. LATENT NO. 79 06502 12/31/80 (BASF A.-G. ) LA - ENG AB - CBAC COPYRIGHT: CHEM ABS The carboxylic acid esters YC02CHZCR1:CR2R3 (R1,R2, and R3 = H, halo, alkyl, or alkenyl; Y = 3-(2,2-dihaiovinyl)-2,2-dimethylcyclopropyl or I; R4 = alkyl, alkenyl, alkynyl, or cycloalkyl 5 R5 = halo, alkyl, alkoxy, tHhalometnyl, CN, or N025 a = 0-3; Z = II or III; X = 0, S, or CH2; Rc, R7, and R8 = halo, alkyl, alkoxy, or haloalkyl; b, c, and d - 0-3) are insecticides and acaricides. Thus, RNW 1607 00009943 VCM PAGE 13 2,2-dimethyl-3-(2'>21-dibromovinyl )-cyclopropanecarboxylic acid 3-phenoxy-alpha-vinylbenzyl ester had a contact LD50 value of 0.014 mug to Musca domestica. (75279-49-1 2 ,2--dimethyl-3-(2'2'-dibromovinyl )-cyclopropanecarboxy1ic acid 3-phenoxy-.alpha.-vinylbenzyl ester) The synthesis of 24 compds. is given. RN 75279-49-15 75-01-4; 598-73-2; 32832-95-4J 39515-51-0J 52314-67-7; 59952-40- 8; 60148-63-2; 72083-99-9; 73436-50-7; 75279-50-4; 75279-51- 5*, 75279-52-6? 78144-40-8; 78144-41-9; 78144-42-0*, 78144-43- i; 78144-44-2; 78144-45-3; 78144-46-4; 78144-47-5; 78144-48- 6; 78144-49-7; 78144-50-0; 78144-51-1*, 78144-52-2; 78144-53- 3; 78144-54-4; 78144-55-5; 78144-56-6; 78144-57-7; 78144-58- 8; 78144-59-9; 78163-73-2 EM 8109 31 SI - CA/095/029316E AU - Ackerman DG ; Haro MT J Richard G ; Takata AM ; Weller PJ AD - Environ. Eng. Div., TRW, Redondo Beach TI - Health impacts, emissions, and emission factors for noncriteria pollutants subject to de minimis guidelines and emitted from stationary conventional combustion processes SO - Report; ISS EPA-450/2-80-074; Order No. PB80-221237,, 1980,106 pp. LA - ENG CD - D8REP AB - CBAC COPYRIGHT: CHEM ABS The report presents a literature survey of the health and ecol. effects assocd. with various air quality levels of noncriteria pollutants that are regulated under the Clean Air Act. These noncriteria pollutants include Be, Hg, asbestos, H2S04 mist, vinyl chloride, H2S, MeSH, Me2S, Me2S2, CS2, and CS. (75-01-4 Vinyl chloride )(74-93-1 Methylthi ol H75-18-3 Dimethylsulf ide H624-92-0 Dimethyldisulfide )(75-15-0 Carbon disulfide )(2944-05-0 Carbon monosulfide) Nationwide emissions are estd. for each noncriteria pollutant with particular emphasis on contributions from fossil fuel combustion at stationary sources. Factors for quantifying emissions from fossil fuel combustion processes are discussed for each noncriteria pollutant. RN - 75-01-4; 74-93-1; 75-18-35 624-92-05 75-15-OJ 2944-05-05 7439-97-6; 7440-41-75 7664-93-95 7783-06-4 EM - 8108 32 SI AU AD TI SO LA CD AB RN CA/095/011681K Wagoner JK 5 Infante PF ; Apfeldorf RB Environ. Defense Fund, Washington Toxicity of vinyl chloride and poly(vinyl chloride) as seen through epidemiologic observations J. Toxicol. Environ. Health; VOL 6, ISS 5-6, 1980,1101-7 ENG JTEHD CBAC COPYRIGHT: CHEM ABS A review with many refs. Review vinyl chloride exposure toxicity PVC toxicity occupational exposure review 75-01-45 9002-86-2 RNW 1608 00009944 VCM PAGE 14 EH - 8108 33 SI - CA/094/213607F AU - Krajewski J ; Miczarska A ; Dobecki M AD - Zakl. Chem. Zanieczyszczen Powietrza, Inst. Pracy Lodz TI - Usefulness of different methods of air sampling for the evaluation of occupational exposure to vinyl chloride SO - Hed. Pr.; VOL 31, ISS 3, 1980,165-70 LA - POL CD - HEPAA AB - CBAC COPYRIGHT: CHEM ABS Vinyl chloride (I) concns. in air were measured in the polymn. room of a PVC plant. (75-01-4 Vinylchloride)(9002-86-2 Polytvinyl chloride)) The stationary sampling of the air did not reflect the actual exposure of the individual workers in varing I levels, 1.9-209.5 mg m-3, depending on their occupational activity. Air sampling with the use of personal miniature pumps is necessary to obtain a reliable evaluation of individual exposures. RN - 75-01-4; 9002-86-2 EM - 8107 34 SI - CA/094/213606E AU - Krajewski J ; Dobecki M ; Milczarska A AD - Zakl. Chem. Zanieczyszczen Powietrza, Inst. Pracy, Lodz TI - Evaluation of the working atmospheres at the PVC plants SO - Med. Pr.*, VOL 31, ISS 2, 1980,149-53 LA - POL CD - MEPAA AB - CBAC COPYRIGHT: CHEM ABS The vinyl chloride (I) concns. in the air at 2 PVC plants in Poland were detd. (75-01-4 Vinyl chloride)(9002-86-2 Polyvinyl chloride) Before modernization of the plants, the concns. exceeded the max. permissible concn., i.e. 30 mg I/m3 air. Esp. in polymn. rooms and during autoclave cleaning, the PVC levels were occasionally higher than 200 and 1500 mg/m-3, resp, Hermetization of the polymn. processes and introduction of mech. cleaning of the autoclave considerably reduced the exposure of workers. RN - 75-01-4; 9002-86-2 EM - 8107 35 SI - CA/094/213398P AD - Research Triangle Park TI - National emission standards for hazardous air pollutants SO - Fed. Regist.5 VOL 45, ISS 224, 1980,76346-54 LA - ENG CD - FEREA AB - CBAC COPYRIGHT: CHEM ABS The method for the detn. of vinyl chloride in stack gases is given in detail, with recent improvements. (75-01-4 Vinyl chloride) RN - 75-01-4 EM - 8107 RNW 1609 00009945 VCM PA6E 15 36 SI - CA/094/196820A AU - Sudo Y ; Nakamura S > Nagasaki S ; Oshima E AD - Tokyo Natl. Tech. Coll., Tokyo TI - Adsorption of vinyl chloride monomer on a natural zeolite SO - Tokyo Kogyo Koto Semmon Gakko Kenkyu Hokokusho; VOL 12 1980,65-70 LA - JPN CD - TKSHD AB - CBAC COPYRIGHT: CHEM ABSVinyl chloride inair was removed by natural zeolite, then thezeolite wasregenerated by heating and steaming. (75-01-4 Vinyl chloride) Heating at >200.degree, deteriorated the adsorptivity and the heating gave better adsorptivity than that by steaming. RN - 75-01-4 EM - 8107 37 SI - CA/094/186640C AU - Bolt HM ; Filser JG ; Wiegand M Buchter A Bolt W AD - Inst. Toxicol., Univ. Tuebingen, Tuebingen TI - Studies on liver microsomal metabolism and interaction of vinyl chloride and related compounds in relation to possible careinogenicity SO - Proc. Int. Congr. Occup. Health, 19th; VOL 1, ISS Chem. Hazards, 1980,369-77 LA - ENG CD - 45K0A AB - CBAC COPYRIGHT: CHEM ABS Halogenated ethylenes and Me chloroform inhibited aminopyrine demethylation much more than aniline hydroxylation in rat liver microsomes in vitro. (71-55-6 Methyl chloroform) Trans-l2-Dichloroethylene caused the greatest inhibition of aminopyrene demethylation. (156-60-5 trans-l2-Dichloroethylene) Apparently, different mechanisms were involved in aminopyrine demethylation inhibition by trans-1,2-dichloroethylene and vinylidene fluoride. (75-38-7 Vinylidene fluoride) Thus, halogenated ethylenes may interact with the hepatic drug-metabolizing monooxygenase system. RN - 71-55-6J 156-60-5J 75-38-7; 74-85-1; 75-01-4; 75-02-5; 75-35-4; 79-01-6; 127-18-4; 156-59-2? 593-60-2 EM - 8107 38 SI - CA/094/179678T AU - Khudobina La ; Safonova IL TI - Toxicity o' vinyl chloride SO - Khim. Prcm-st. Rubezhom? ISS 9, 1980,39-60 LA - RUS CD - KPRUD AB - CBAC CGPYRIGHT: CHEM ABS A review with 208 refs. toxicity vinyl chloride RN - 75-01-4 EM - 8106 Review RNW 1610 00009946 VCM PAGE 16 39 SI - CA/094/161861N AU - Dobecki M 5 Krajewski J AD - Dep. Chem. Anal. Air Pollutants, Inst. Occup. Med., Lodz TI - Gas chromatographic determination of vinyl chloride and vinyl acetate in the air at work places SO - Chem. Anal. (Warsaw); VOL 25, ISS 3, 1980,351-7 LA - POL CD - CANWA AB - CBAC COPYRIGHT: CHEM ABS Air samples contg. CH2:CHCl and AcOCH:CH2 were adsorbed on activated C, desorbed with CS2, and analysed with a column packed with 10/ Carbowax 20 M on Chromosorb W AW DMCS. (75-01-4 Vinyl chloride )(108-05-4 Vinyl acetate) The carrier gas was N at 0.5-cm3/s and 60.degree, column temp. The method can det. 2.5 AcOCH:CH2 and 7.5 mg CH2:CHCl/m3. RN - 75-01-4; 108-05-4 EM - 8106 40 SI - CA/094/144585H AU - Altshuller AP AD - EPA, Research Triangle Park TI - Comments on the lifetimes of organic molecules in air SO - U. S. Environ. Prot. Agency, Off. Res. Dev., [Rep.] EPA; ISS EPA-600/9-80-003, Proc. Conf. Methyl Chloroform Other Halocarbon Pollut.,, 1980,1/1-1/10 LA - ENG CD - XPARD AB - CBAC COPYRIGHT: CHEM ABS The lifetimes of halo hydrocarbons and other orgs. in air were given. RN - 50-00-0; 64-17-5; 67-56-1', 67-66-3', 71-43-2', 71-55-6', 74-82-8', 74-83-9; 74-84-0', 74-85-1; 74-86-2; 74-87-35 74-98-6 5 75-00-35 75-01-4; 75-09-2; 75-10-5; 75-28-55 75-34-35 75-37-6; 75-43-4; 75-45-6', 75-46-7 5 75-68-35 75-88-7 5 78-78-4', 78-93-35 79-01-6', 79-20-9; 106-93-4', 106-97-85 107-06-25 108-38-3; 108-67-8', 108-88-35 110-54-35 110-82-7; 115-07-1', 127-18-4; 141-78-6; 306-83-25 463-82-1', 593-53-35 593-70-4', 1649-08-7; 2837-89-0', 62309-51-7 EM - 8105 41 SI - CA/094/144493B AU - Krajewski J 5 Milczarska A 5 Dobecki M AD - Inst. Occup. Med. Text. Chem. Ind. Lodz TI - Suitability of air sampling techniques for the evaluation of occupational exposure to toxic substances SO - Gig. Tr. Prof. Zabol.5 ISS 10, 1980,17-20 LA - RUS CD - GTPZA AB - CBAC COPYRIGHT: CHEM ABS The av. concn. (.hivin.x) was detd. of vinyl chloride (VC) in air, sampled by different techniques at the plant for the prodn. of PVC. (75-01-4 Vinyl chloride)(9002-86-2 PVC) The distribution of various sampling sites, the value of .hivin.x in air samples over different RNW 1611 00009947 VCM PAGE 17 operating zones (loading ramp* service bay, etc.), and variations in .hivin.x value over a period of 30 days were detd. The values of .hivin.x do not reflect adequately the extent of occupational hazard due to exposure to vc. The level of exposure (1.6-209.5 mg/m3 of air) was highly variable and depended on the kind of work performed. RN - 75-01-4; 9002-86-2 EM - 8105 42 SI - CA/094/115233M AU - Bogdanlkowa B AD - Zespol Klin., Inst. Med. Pracy, Lodz TI - Pathomechanism of the disease caused by chronic exposure to vinyl chloride SO - Przegl. LeK.J VOL 37, ISS 12, 1980,797-801 LA - POL CD - PRLKA AB - CBAC COPYRIGHT: CHEM ABS A review on vinyl chloride with regard to the title subject; 53 refs. (75-01-4 Vinyl chloride) RN - 75-01-4 EM - 8105 43 SI - CA/094/108476Q AU - Roessr.er P ; Sram RJ ; Novakova J ; Lambl V AD - Inst. Kya. Epidemiol., Prague TI - Cytogenetic analysis in workers occupationally exposed to vinyl chloride SO - Mutat. Res.; VOL 73, ISS 2, 1980,425-7 LA - ENG CD - MUREA AB - CBAC COPYRIGHT: CHEM ABS Preventative cytogenetic examns. of workers exposed to vinyl chloride monomer (I) indicate that, if the I concn. in the air of the work place is <10 mg/m3, no increase will develop in the no. of chromosomal aberrations depictable in peripheral lymphocytes of these workers. RN - 75-01-4 EM - 8104 44 SI - CA/094/108463H AU - Diehl H ; Grambow L ; Huneke KH TI - Toxiwarn - a portable measuring and warning device for toxic gases SO - Draeger Rev.; VOL 45,, 1980,39-52 LA - ENG CD - DRARA AB - CBAC COPYRIGHT: CHEM ABS The Toxiwarn is a measuring and warning instrument which operates in a continuous manner and uses a cassette contg. indicator paper which reacts specifically with a toxic substance. Tapes are available for NH3, Cl, HC1, HCN, H2S, N02, C0C12, and vinyl chloride. (75-44-5 Phosgene)(75-01-4 Vinyl chloride) The user is warned acoustically and optically for .ltoreq.10 h, and av. concns. are read from a digital display after 2, 4, and 8 h. RN - 75-44-5J 75-01-4J 74-90-8J 7647-01-0; 7664-41-7; 7782-50-5; RNW 1612 00009948 VCM PAGE 18 # 7783-06-4? 10102-44-0 EM - 8104 # 45 SI - CA/094/089380K AU - Antonov 6 Spasovski M AD - Inst. Gig. Profsabol., Sofia TI - Study of some blood serum indexes in workers exposed to vinyl # chloride SO - Gig. Tr. Prof. Zabol.; 1SS 8, 1980,47-8 LA - RUS CD - GTPZA AB - CBAC COPYRIGHT: CHEM ABS The exposure to vinyl chloride (I) of factory workers produces changes in the connective tissues of the body. (75-01-4 Vinyl chloride) The levels of hydroxyproline and hexosemines in blood serum of these workers are increased, # demonstrating that I causes decompn. of collagens. (51-35-4 Hydroxyproline) These effect of I are masked in workers older than 50 yr by the onset of aging processes. Other diseases (e.g. rheumatism, arthritis, arteriosclerosis ) also produce degrdn. of collagens and can mask the effect of I. RN - 75-01-4; 51-35-4 EM - 8104 46 SI - CA/094/077927F AU - Sharma RP j Yakel HO ; Gehring PJ AD - Toxicol. Program, Utah State Univ. Logan TI - Immunotoxicologicstudies withvinyl chloride in rabbits and mice # SO - Int. J.Immunopharmacol.5 VOL 2, ISS 4,1980,295-9 LA - ENG CD - IJIMD AB - CBAC COPYRIGHT: CHEM ABS The effects of vinyl chloride (VC) exposure on induced immunologic responses in rabbits are described. (75-01-4 Vinyl chloride) No consistent effect of VC exposure was noticed on skin reactivity to tuberculin or serum anti tetanus titers in sensitised rabbits. VC produced no change * in the no. of antibody secreting cells in the lymph nodes of immunised rabbits. An increase in the spontaneous splenic lymphocyte transformation in immunised rabbits was obsd. when the animals were exposed to VC. Two known metabolites of VC, thiodiglycolic acid and N-acetyl-S-(hydroxyethyl)cysteine produced little or not effect when added to mouse splenic lymphocyte cultures in vitro but in vivo administration of thiodiglycolic acid produced apparent immune stimulation in mice. * (123-93-3 Thiodiglycolic acid)(15060-26-1 N-acetyl-S-(hydroxyethyl )cysteine) Thus, although VC may cause an apparent enhancement of immune reactivity, it does not alter the immunologic response to simultaneously administered antigens. RN - 75-01-4*, 123-93-3; 15060-26-1 EM - 8104 RNW 1613 # 00009949 VCM PAGE 19 47 SI - CA/094/059525U AU - Poncelet F ; De Meester C ; Duverger-Van Bogaert M AU - Lambotte-Vandepaer M Roberfroid M ; Mercier M AD - Sch. Pharm., Univ. Louvain, Brussels TI - Influence of experimental factors on the mutagenicity of vinylic monomers SO - Arch. Toxicol., Suppl.5 VOL 4,, 1980,63-6 LA - ENG CD - ATSUD AB - CBAC COPYRIGHT: CHEM ABS Various exptl. conditions, modes of incubation, and the presence of different metabolic activating systems had a variable effect on the mutagenic potency of styrene, butadiene, acrylonitrile, and vinyl chloride on strains of Salmonella typhimurium. C100-42-5 Styrene)(106-99-0 Butadiene)(107-13-1 Acrylonitrile)(75-01-4 Vinyl chloride) Styrene had a mutagenic activity in plate incorporation tests only. Contrarily, the mutagenic effects of butadiene and vinyl chloride were only obsd. when assays were performed in gaseous atms., the latter in the absence of a metabolic activating system. Acrylonitrile was also mutagenic in the gaseous phase but, in addn., seemed to be the only compd. active after incubation in liq. medium. The increased mutagenic effects detected after pretreatment of rats and mice by these vinyl monomers raises the problem of hazards related to the consecutive exposure of humans to acrylonitrile vapors. RN - 100-42-5; 106-99-0; 107-13-1; 75-01-4 EM - 8104 48 SI AU AD TI SO LA CD AB RN EM CA/094/052024W Drugov YS 5 Murav'eva GV Sci . Res. Inst. Labour Hyg. Prof. Des. Moscow Selective gas chromatographic determination of chlorinated hydrocarbons in air with preliminary removal of interfering impurities Zh. Anal. Khim.; VOL 35, ISS 7, 1980,1319-25 RUS ZAKHA CBAC COPYRIGHT: CHEM ABS Vinyl chloride (I), CCl2:CClH, and CC12:CC12 can be detd. in air by gas chromatog. when their concns. are .gtoreq.0.05 mg/m3. (75-01-4 Vinyl chloride )(79-01-6 Trichlorethylene)(127-18-4 Tetrachloroethylene ) Air contg. these compds. is drawn through a column packed with 3 sep. layers: zeolite 5A, glass fiber satd. with coned. H2S04, and Na2C03. This removes practically all org. compds., except org. halides. The air is next drawn through a cold trap contg. active carbon which absorbs org. halides. The carbon is extd. with PhCl and the exts. are gas chromatographed on a column filled with carbon black contg. 0.2V. poly(ethylene glycol). 75-01-4; 79-01-6*, 127-18-4 8103 RNW 1614 m i 00009950 VCM PAGE 20 49 SI - CA/094/035484D All - Marthinsson B 5 Johansson J 5 Eng ST AD - Dep. Electr. Haas.) Chalmers Univ. Technol., Goeteborg TI - Air pollution monitoring with a computer-controlled carbon dioxide-laser long-path absorption system SO - Opt. Quantum Electron., VOL 12, ISS 4, 1980,327-34 LA - ENG CD - OQELD AB - CBAC COPYRIGHT: CHEM ABS A C02-laser long-path absorption system has been developed. It is highly automated with compute!--controlled laser-line selection and real-time data processing. The system was used to monitor C2H4 and vinyl chloride concns. over a petrochem. factory area. (74-85-1 Ethylene)(75-01-4 Vinyl chloride) The C2H4 concns. were <0.02-45 ppm. The vinyl chloride concns. were <0.05 ppm. Different path lengths from 20 to 2800 m were used. The min. detectable C2H4 concn. was typically 15 ppm. RN - 74-85-15 75-01-4 EM - 8103 50 SI - CA/094/042203Q AU - Baird R ; Gute J j Jacks C ; Jenkins R ; Neisess L ; Scheybeler B All - Van Sluis R ; Yanko W AD - San Jose Creek Water Qual. Lab., County Sanit. Dist. Los Angeles County, Whittier TI - Health effects of water reuse: a combination of toxicological and chemical methods for assessment SO - Water Chlorination: Environ. Impact Health Eff.5 VOL 3,, 1980,525-35 LA - ENG CD - WCEED AB - CBAC COPYRIGHT: CHEN ABS Chlorinated and unchlorinated samples from H20 reclamation plants and potable groundwater wells were coned, cn a high-pressure macroreticular resin system and the orgs. removed from the resins were tested for mutagenicity by the Ames test. One of the 3 treatment facilities and 3 of the 10 wells exhibited mutagenesis. All of the chlorinated samples contained direct-acting mutagens. The mutagenic components were sepd. by high-performance liq. chromatog. and then, the gas chromatog.-mass spectroscopy was used to detect sp. mutagens from the water. RN - 56-23-5; 67-66-3', 71-43-2; 75-01-4; 75-09-25 75-25-25 75-27-4; 75-34-35 79-00-55 79-01-65 95-50-1; 106-46-7', 107-06-25 108-88-3; 108-90-7', 124-48-15 127-18-4 EM - 8103 RNW 1615 00009951 VCM PAGE 21 51 SI - CA/093/031081B AU - Krasnec J AD - Natl. Cent. Atmos. Res.* Boulder TI - A direct and sensitive gas chromatographic method for selective measurement of vinyl chloride in ambient air. Comments SO - Atmos. Environ.; VOL 14, ISS 3, 1980,391 LA - ENG CD - ATENB AB - CBAC COPYRIGHT: CHEM ABS A polemic in answer to E. Burghardt et al. (ibid 1979, 13, 1057-60) is given. RN - 75-01-4 EH - 8008 52 SI - CA/093/031080A AU - Burghardt E J Van de Hi el HJ ; Oranje EJ ; Jeltes R AD - Res. Inst. Environ. Hyg. TNO, Delft TI - A direct and sensitive gas chromatographic method for selective measurement of vinyl chloride in ambient air. Reply to comments SO - Atmos. Environ.; VOL 14, ISS 3, 1980,391-2 LA - ENG CD - ATENB AB - CBAC COPYRIGHT: CHEM ABS A polemic in answer to J. Krasnec (ibid.1980, 14, 391-2) is given. A gas chromatogram of synthetic air spiked with 13 ppb vinyl chloride confirms the lower detection limit of 2 ppb. (75-01-4 Vinyl chloride) RN - 75-01-4 EM - 8008 53 SI - CA/093/020484J AU - Bartsch H ; Hontesano R AD - Unit Chem. Carcinog., IARC, Lyon TI - Prescreening of environmental and industrial chemicals in a series of short-term tests for the detection of potential carcinogens SO - Comm. Eur. Communities, [Rep.3 EUR; ISS EUR 6388, Environ. Res. Programme,, 1980,269-73 LA - ENG CD - CECED AB - CBAC COPYRIGHT: CHEM ABS The mutagenicity of 12 halo olefins and related epoxides in Salmonella typhimurium in descending order was; 3,4-dichlorobutene-1 > 2-chlorobutadiene (tech, grade) > 1-chlorobutadiene > vinyl bromide (VB) > vinylidene chloride > vinyl chloride (VC); marginal mtagenicity was detected in the presence of 1,1,2-trichloroethylene and 1,1-difluoroethylene, and none with tetrachloroethylene and vinyl acetate. (760-23-6 3,4-dichlorobutene-1)(126-99-8 2-chlorobutadiene)(627-22-5 1-Chlorobutadiene )(593-60-2 Vinyl bromide )(75-35-4 Vinylidene chloride)(75-01-4 Vinyl chloride )(79-01-6 1,1,2-Trichloroethylene )(75-38-7 1,1-difluoroethylene )(127-18-4 Tetrachloroethylene )(108-05-4 Vinyl acetate) In the presence of human liver fractions, VB, VC, vinylidene chloride, and 2-chlorobutadiene were converted into mutagens. No good RNW 1616 00009952 VCM PAGE 22 correlation was found between the mutagenic and alkylating activities of the compds. with 4-( 4-nitrobenzyl )pyridine. However, good correlations were obsd. for VC, VB, and 2-chlorobutadiene when fortified mouse liver rnicrosomes were added to the assays. Vapor of VC induced mutations in V79 Chinese hamster cells in the presence of liver supernatant from phenobarbitone-pretreated rats. RN - 760-23-6; 126-99-85 627-22-5J 593-60-25 75-35-4; 75-01-45 79-01-65 75-38-75 127-18-45 108-05-45 106-89-85 764-41-05 3583-47-95 7763-77-1 EM - 8008 54 SI - CA/092/192236A AU - Sal'nikova LS 5 Kitsovskaya 1A AD - Inst. Gig. Tr. Profzabol., Moscow TI - Effect of vinyl chloride on embryogenesis of rats SO - Gig. Tr. Prof. Zabol.5 ISS 3, 1980,46-7 LA - RUS CD - GTPZA AB - CBAC COPYRIGHT: CHEM ABS Inhalation of 4.8 or 35.5 mg vinyl chloride/m3 4 h/day during the entire pregnancy, increased the percentage of rat fetuses with hemorrhages by 49.3 and 51.2X, resp. (75-01-4 Vinyl chloride) The antenatal action of 35.5 mg vinyl chloride/m3 inhibited the orientation reaction in male offspring, lowered their blood Hb, and decreased the wt. coeffs. of heart, liver, kidneys, and spleen. In female offspring, the heart wt. coeff. was decreased, the blood leukocyte level and the urine hippuric acid level raised, and sleep prolonged. The lower vinyl chloride level also caused a no. of changes in the offspring. RN - 75-01-4 DTG - MAXIMUM PERMISSABLE LIMIT 5 CHRONIC TOXIC DOSE EM - 8007 55 SI - CA/092/175184Q AU - Sheftel VO AD - Vses. Nauchno-Issled. Inst. Gig. Toksikol. Pest its. Polimern. Plast. Mass, Kiev TI - Hazards of vinyl chloride migration into water and foods SO - Gig. Sanit.5 ISS 2, 1980,63-5 LA - RUS CD - GISAA AB - CBAC COPYRIGHT: CHEM ABS A review with 13 refs. Review vinyl chloride food water RN - 75-01-4 EM - 8006 RNW 1617 00009953 VCM PAGE 23 56 SI - CA/092/123086Q AU - Peter S ; Ungvary G AD - Lab. Hum. Genet. State Inst. Hyg., Budapest TI - Lack of mutagenic effect of vinyl chloride monomer in the mammalian spot test SO - Mutat. Res.; VOL 77, ISS 2, 1980,193-6 LA - ENG CD - MUREA AB - CBAC COPYRIGHT: CHEM ABS Exposure of female mice on the 10th day of pregnancy to 12,000 mg/m3 (4600 ppm) atm. concn. of vinyl chloride (I) monomer for 5 h did not result in any abnormal morphol. in the offsprings. (75-01-4 Vinyl chloride) Midventral white spots occurred at a frequency of 2.8^ but this did not differ from the relative control value. Thus, no somatic gene mutations were induced by I monomer in mammals in vivo. RN - 75-01-4 EM - 8005 57 SI - CA/092/105572R AU - De Meester C ; Duverger-Van Bogaert M 5 Lambotte-Vandepaer M AU - Roberfroid M ; Poncelet F ; Mercier M AD - Sch. Pharm., Univ. Louvain, Brussels TI - Mutagenicity of vinyl chloride in the Ames test. Possible artifacts related to experimental conditions SO - Mutat. Res.; VOL 77, ISS 2, 1980,175-9 LA - ENG CD - MUREA AB - CBAC COPYRIGHT: CHEM ABS Vinyl chloride (I) (2-20V. in the atm.) had a concn.-dependent direct mutagenic activity against Salmonella typhimurium. (75-01-4 Vinyl chloride) The mutagenicity of I was strongly enhanced by a fortified metabolising liver ext. The simultaneous presence of plates contg. the liver S 9 mixt. with plates without the liver ext. in the incubation dessicator enhanced the mutagenicity of I towards bacteria inoculated on the plates without S 9. The enhancement was even more pronounced when the S 9 mixt. had been obtained from mice that had been pretreated with an inducing agent, however, the results were affected by exptl. conditions, e.g. the amt. of volatile metabolites, dessicator vol., no. of plates, and compn. of the plates. The mutagenicity of I may be due to its metab. to proximate mutagens. RN - 75-01-4 EM - 8004 58 SI - CA/096/011052B CC - CA/159005 AU - Ciugudeanu M ; Metes L ; Zugravu E 5 Colosi D ; Anca Z ; Gabor S AU - Preda N 5 Suciu I AD - Inst. Igiena Sanatate Publ. Cluj-Napoca TI - Study of the behavior of some serum enzymes in workers occupationally exposed to vinyl chloride SO - Rev. Ig., Bacteriol., Virusol., Parazitol., Epidemiol., RNW 1618 00009954 VCM PAGE 24 Pneumoftiziol.> Ig.; VOL 28, ISS 3, 1979,237-42 PT - JOURNAL ARTICLE CY - Rom. LA - RUM CD - RABID AB - CBAC COPYRIGHT: CHEM ABS Serum enzyme vinyl chloride exposureJBlood serum Enzymes of, vinyl chloride exposure in relation tojHealth hazard Of vinyl chloride exposure, blood serum enzymes in relation to Occupational RN - 75-01-45 9000-86-65 9000-97-9; 9001-08-5*, 9001-46-1; 9001-60-9J 9001-78-9*, 9046-27-9 EM - 8204 59 SI - CA/091/180464Q AU - Leleu MJ AD - Inst. Natl. Rech. Secur., Paris TI - Dangerous chemical reactions. 64. Halogenated hydrocarbons. Part 1 SO - Cah. Notes Doc.; VOL 96,, 1979,451-60 LA - FRE CD - CNDIB AB - CBAC COPYRIGHT: CHEM ABS ADDENDUM Explosive or similarly vigorous reactions between halogenated hydrocarbons and other chems. are described and referenced. RN - 67-68-5; 74-83-9J 74-86-2} 74-87-35 74-95-35 75-00-35 75-01-4} 75-09-25 75-11-65 75-28-5} 75-35-4; 75-45-65 75-63-8} 75-69-45 75-71-85 75-73-05 76-13-15 76-14-2} 78-87-5; 79-38-9; 92-52-45 95-50-1} 96-40-25 98-56-65 106-96-7} 107-06-25 540-59-05 593-61-35 593-63-5} 624-61-3; 624-65-7} 624-74-8} 659-86-9} 821-10-3} 865-47-45 1310-58-3; 1314-13-25 1781-66-4} 1890-04-65 2713-09-95 6088-91-15 7429-90-55 7439-93-2} 7439-95-4; 7439-97-6} 7440-09-75 7440-22-4} 7440-23-5} 7440-50-85 7440-66-6} 7572-29-45 7616-94-6} 7664-41-75 7726-95-65 7761-88-8} 7782-44-7; 7782-50-5! 10028-15-6*, 10034-81-8; 10045-94-05 10102-03-1; 10544-72-6} 11135-81-2; 16260-59-6*, 16853-85-3*, 17530-57-3; 25512-47-4; 27154-33-2 5 44750-17-6*, 53214-97-4 5 15590-23-5 EM - 8007 60 SI - CA/095/102249S AU - Knoll JE } Midgett MR AD - Environ. Monitoring and Support Lab., Environ. Prot. Agency, Research Triangle Park TI - Quality assurance aspects of the collaborative testing of EPA Method 106 - determination of vinyl chloride from stationary sources SO - Spec. Conf.: Qual. Assur. Air Pollut. Meas., tProc.3 *, 1979,442-7 LA - ENG CD - 45QDA AB - CBAC COPYRIGHT: CHEM ABS Quality assurance procedures were applied to improve the value of data obtained in the collaborative testing of the EPA method 106, which is used at plants manufg. ethylene dichloride, vinyl chloride, and polyvinyl chloride and involves the extn. of an integrated gas sample from RNW 1619 00009955 VCM PAGE 25 an effluenT stream and the measurement of the vinyl chloride content by gas chromatog. (107-06-2 Ethylene dichloride)(75-01-4 Vinyl chloride)(9002-86-2 Polyvinyl chloride) The techniques used in organizing the test* in the acquisition of data* and in data anal, are described. The results of both a lab. and a field test are presented* and the applicability is discussed. RN - 107-06-2; 75-01-45 9002-86-2 EM - 8110 61 SI - CA/0 94/196848R AU - Belanger PL > Elesh E AD - Health Hazard Tech. Assist. Branch* Natl. Inst. Occup. Safety Health* Cincinnati TI - Health evaluation and technical assistance* report No. HE 78-71-633, Kentile Floors* Inc.* Brooklyn, New York (USA) SO - Report; ISS NIOSH-HE-78-71-633; Order No. PB80-195308,, 1979,25 pp. LA - ENG CD - D8REP AB - CBAC COPYRIGHTS CHEM ABS Environmental air sampling, medical interviews and evaluations, and observations of work practices were conducted on July 10, Sept. 25 and 26, and Oct. 23-25, 1978 to evaluate exposures to asbestos, asphalt, vinyl chloride, dyes, and pigments. (75-01-4 Vinyl chloride) The company employed 370 workers and an authorized employee representative requested the evaluation on behalf of approx. 75 affected employees. Three of 30 environmental air samples for asbestos (0.11* 0.11, and 0.12 fibers/cm3) exceeded the OSHA recommended criteria of 0.10 fibers/cm3. All other parameters tested were within recommended exposure limits. The only evidence of work related illness involved 1 case of contact dermatitis. NIOSH recommendations include proper use of exhaust ventilation, use of safety equipment in all operations* identification of carcinogenic chern.* proper cleaning of the work clothes of men exposed to asbestos* and elimination of the use of dianisidine. (119-90-4 Dianisidine ) RN - 75-01-4J 119-90-4 EM - 8107 62 SI - CA/094/052097X AU - Belanger PL ; Elesh E AD - Natl. Inst. Occup. Saf. Health, Cincinnati TI - Hazard evaluation and technical assistance report No. HE 78-73-612, Kentile Floors, Inc.* Chicago* Illinois SO - Report; ISS NIOSH-TR-HHE-78-73-612; Order No. PB80-161094,, 1979,26 pp. LA - ENG CD - D8REP AB - CBAC COPYRIGHT: CHEM ABS An environmental and medical survey was conducted on June 26 and 27* and Aug. 19 to 22* 1978 at Kentile Floors, Incorporated* Chicago* Illinois at the request of an authorized employee representative to det. the potential exposure of 50 employees to asbestos, polynuclear arom. RNW 1620 00009956 VCM PAGE 26 hydrocarbons* vinyl chloride* talc* alpha-methyl styrene* and numerous org. and inorg. dyes and pigments used in the prodn. of vinyl asbestos and asphalt asbestos floor coverings. (75-01-4 Vinyl chloride )(14807-96-6 Talc)(98-83-9 .alpha.-Methyl styrene) The investigators recommend an inventory and periodic monitoring of toxic chem. and that employees be instructed on proper respirator use and other safety precautions. A canopy exhaust system should be installed* carcinogenic chem. should be identified and stored sep. from noncarcinogens* the ventilation exhaust systems should be inspected periodically* and workers potentially exposed to asbestos should change clothes and shower before leaving the workplace. RN - 75-01-45 14807-96-65 98-83-9 EM - 8103 63 SI - CA/094/042439U AU - Bolt HM ; Laib RJ ; Filser JG ; Ottenwaelder H 5 Stoeckle G AU - Buchter A ; Bolt W AD - Inst. Toxikol.* Univ. Tuebingen* Tuebingen TI - Toxicological problems with brominated and fluorinated vinyl chloride analog monomers SO - Krebsgefaehrdung Arbeitsplats/Arbeitsmed. Kolloq.* Ber. Jahrestag. Dtsch. Ges. Arbeitsmed.* 19th; 1979,195-203 LA - GER CD - 44URA AB - CBAC COPYRIGHT: CHEM ABS In 10.3 L closed containers with 0 replenishment and C02 removal* and stocked with 3 rats* the vinyl chloride concn. decreased linearly as a 0-order process from 1100 to 250 ppm within 6 h, and then decreased logarithmically as a lst-order process, until vinyl chloride disappeared within the next 5.5 h. (75-01-4 Vinyl chloride) Vinyl bromide dissipation shifted from the 0- to lst-order kinetics at 55 ppm and the metabolisat ion was slower in the 0-order range. (593-60-2 Vinyl bromide) The rates of vinyl fluoride and vinylidene fluoride metabolisation were 6 and 17. of the vinyl chloride metabolisation rate, resp. (75-02-5 Vinyl fluoride)(75-38-7 vinylidene fluoride) The hepatocarcinogenic potential of vinylidene fluoride is low because of its slow metabolisat ion. RN - 75-01-4; 593-60-2J 75-02-55 75-38-7 EM - 8103 64 SI - CA/094/025980Y AU - Kucerova M 5 Polivkova Z 5 Batora J AD - Inst. Dalsi Vsdelavani Lek. Farm., Prague TI - Mutagenic and carcinogenic effects of vinyl chloride SO - Prac. Lek.; VOL 31, ISS 6-7, 1979,249-52 LA - CZE CD - PRLFA AB - CBAC COPYRIGHT: CHEM ABS Workers exposed to 0-6000, and most frequently to 20-150, ppm vinyl chloride for 10-27 yr had 5.22 of lymphocytes with chromosomal aberrations compared with 1.B7. in controls* and the no. of sister chromatid exchanges was increased from 9.41 to 13.80/lymphocyte. (75-01-4 Vinyl chloride) RNW 1621 00009957 VCM PAGE 27 Chromatid and chromatin breaks pervailed, and chromatid and chromosome exchanges also were frequent. RN - 75-01-4 EH - 8103 65 SI - CA/094/019850Q AU - Crider LB ; O'Mara MM ; Bowles RL AD - Avon Lake Tech. Cent., BFGoodrich Chem. Div., Avon Lake TI - A model for the diffusion of vinyl chloride monomer from PVC under various conditions of storage SO - J. Vinyl Technol.; VOL 1, ISS 3, 1979,168-71 LA - ENG CD - JVTED AB - CBAC COPYRIGHT! CHEM ABS A computer optimised exp. design involving 24 expts. was used to obtain a math, model of vinyl chloride (I) emission from granular PVC during storage in sealed 55 gal drums. (75-01-4 Vinyl chloride)(9002-86-2 PVC) The design variables were temp. (T in .degree.F), ventilation rate (V in turnover/h), loading CL, (PVC vol.)/(storage vol.).times. 100], the initial concn. of I in resin (Co in ppm), and storage time (t). Then C = Col.47L0.37V-1.56CT6.0 exp-(24.1 + .00031Tt), where C is the ppb of I in the space above PVC. The model was used to predict C in 3 different warehouses. Excellent agreement between the calcd. and actual C was obtained. RN - 75-01-4; 9002-86-2 EM - 8102 66 SI - CA/093/224970Z AU - Hasegawa H ; Sato M ; Okonogi K ; Shimaoka A ; Tsuruta H AD - Natl. Inst. Ind. Health, Kawasaki TI - Examination of workers in polymerisation process of vinyl chloride monomer (VCM) SO - Ind. Health; VOL 17, ISS 3, 1979,153-85 LA - ENG CD - INHEA AB - CBAC COPYRIGHT: CHEM ABS Data are given on the effects of occupational exposure to vinyl chloride monomer on blood pressure; serum guanosine triphosphate; blood catalase; blood platelets; reticulocytes; glutamic-oxalacetic transaminase, glutamic-pyruvic transaminase, alk. phosphatase, lactic dehydrogenase activity, lactic dehydrogenase isosyme activity, and lipids in the serum} vinyl chloride monomer in the blood; glycerides, free and total cholesterol; beta-lipoproteins; and fatty acids. (75-01-4 Vinyl chloride )(86-01-1 Guanosine triphosphate )(9001-05-2 Catalase )(9000-97-9 Glutamic-oxalacetic transaminase )(9000-86-6 Glutamic-pyruvic transaminase)(9001-78-9 Alk. phosphatase)(9001-60-9 Lactic dehydrogenase )(57-88-5 cholesterol) RN - 75-01-4} 86-01-1; 9001-05-2; 9000-97-9; 9000-86-6; 9001-78-9; 9001-60-95 57-88-55 9002-86-2 EM - 8101 RNW 1622 00009958 VCM PAGE 28 67 SI AU AD TI SO LA CD AB RN EM 68 SI AU AD TI SO LA CD AB RN EM 69 SI AU AD TI SO LA CD AB RN EM CA/093/209369S Kenson RE Oxy-Catal. Inc. West Chester Toxic air pollution emission control with engineered systems Spec. Conf.: Control Specific (Toxic) Pollut. CProc.i ; 1979,255-62 ENG 93SXA CBAC COPYRIGHT: CHEM ABS The review with no refs, covers engineered systems for control of air emissions, including methylene chloride, vinyl chloride monomer, and benzene. (75-09-2 Methylene chloride)(75-01-9 Vinyl chloride monomer)(71-93-2 Benzene) 75-09-25 75-01-9; 71-93-2 8012 CA/093/191289Y Haguenoer JM ; Frimat P > Cantineau A ; Pollard F ; Bobowski R Inst. Med. Trav. Fac. Med., Lille Risks associated with vinyl chloride (MVC) and their prevention in a polymerization unit Arch. Mai. Prof. Med. Trav. Secur. Soc.j VOL 90, ISS 12, 1979,1115-30 FRE AMPMA CBAC COPYRIGHT: CHEM ABS The concns. of vinyl chloride (I) in the air of a factory which went on stream in 1976 were, during the 1977-8 period, 0.30-0.90 ppm near the polymn. reactors, 0.05-2.75 ppm near I recovery units, and 0.06-1.60 ppm near the polytvinyl chloride) driers. (75-01-9 Vinyl chloride )(9002-86-2 PVC) The high I concns. were due to tech, malfunctions. The factory workers, at that point, had not been affected by exposure to these I levels. 75-01-9; 9002-86-2 8012 CA/093/199332C Scrima M Lab. Chim. Prov. Pesaro, Urbino A chemical hypothesis on the possible carcinogenicity of styrene G. Ital. Med. Lav.; VOL 1, ISS 3, 1979,131-2 ITA GIMLD CBAC COPYRIGHT: CHEM ABS Structural analogies and reactivity of vinyl chloride and styrene are pointed out as possibly responsible for the similar carcinogenic effect of these compds. (75-01-9 Vinyl chloride)(100-92-5 Styrene) 75-01-9*, 100-92-5 8011 RNW 1623 00009959 VCM PAGE 29 70 SI - CA/093/078751K AU - Miura T Nakamura S ; Matsunaga I ; Hayashl M ; Suenaka T AU - Hi rata M 5 Hara I AD - Osaka Prefect. Inst. Public Health, Osaka TI - Industrial hygienic survey of factories processing poly(vinyl chloride) resin in Osaka SO - Osaka-furitsu Koshu Eisei Kenkyusho Kenkyu Hokoku, Rodo Eisei Hen; VOL 17,, 1979,45-53 LA - JPN CD - OFKIA AB - CBAC COPYRIGHT! CHEM ABS The title survey covered extrusion, paste-processing, and injection molding plants over the Apr.-Dec. period in 1977. Contamination of environmental air by vinyl chloride monomer was .ltoreq.26 ppm. (75-01-4 Vinyl chloride) RN - 75-01-45 9002-86-2 EM - 8009 71 SI - CA/093/078620S AU - Matsumura Y AD - Sangyo Igaku Sogo Kenkyusho TI - Adsorption of pollutants with activated carbon SO - Kankyo Kagaku Tokubetsu Kenkyu Shinpojumu Yoshishu! VOL 1,, 1979,28-31 LA - JPN CD - 43AZA AB - CBAC COPYRIGHT: CHEM ABS Pollutants (e.g., chlorinated hydrocarbons, NOx, Hg vapors, and NH3) were adsorbed from air by surface-treated activated C in a dynamic gas-adsorption app. to study the adsorption characteristics. The org. pollutant-adsorption capacity of activated C was lowered by the presence of moisture in the air sample. Compared to triethanolamine-silica gel, zeolite, and silica gel, the initial NOx-adsorption rate was greater for activated C. (102-71-6 Triethanolamine) When the activated C was modified by treatment with liq. oxidants (e.g., acidic K2Cr207 soln.), the sorption of Hg vapors and NH3 increased. RN - 102-71-6J 56-23-5; 75-00-3; 75-01-4; 75-35-4; 109-66-0; 110-54-3; 111-65-9; 142-82-5J 7439-97-6; 7440-44-05 7664-41-75 7778-50-9J 11104-93-1 EM - 8009 72 SI - CA/093/031103K AU - Leichnitz K TI - Some information on the long-term measuring system for gases and vapors SO - Draeger Rev.5 VOL 43,, 1979,6-13 LA - ENG CD - DRARA AB - CBAC COPYRIGHT: CHEM ABS Draeger tubes, used with pumps to detect 16 gaseous pollutants (e.g., CO, S02, and hydrocarbons) in the workplace over long periods (4-8 h), as described, including the indicating reactions that occur in the tubes, interfering RNW 1624 00009960 VCM PAGE 30 compels. > and appropriate pollutant concn. ranges. RN - 71-43-2J 74-90-85 75-01-4; 79-01-65 108-88-3; 124-38-9; 126-99-85 630-08-0! 7446-09-55 7647-01-0; 7664-41-7; 7782-50-5; 7783-06-4; 10102-44-05 11104-93-1 EM - 8008 73 SI AU AD TI SO LA CD AB RN EM CA/093/031007G Ichibashi M Kawasaki Munic. Res. Inst. Environ. Prot. Kawasaki The real status of air pollution. 2. Atmospheric organic compounds in Kawasaki Kanagawa-ken Taiki Osen Chosa Kenkyu Hokoku; VOL 21,, 1979,131-43 JPN KTOHD CBAC COPYRIGHT? CHEM ABS Atm. org. compds. in Kawasaki were detd. by gas chromatog.-mass spectroscopy and mass fragmentog. Halogenated hydrocarbons detd. included Freon 11, Freon 113, CH2:CC12, CC12CH3, C1CH:CC12, C12C?CC12, and chloroprene. (75-69-4 Freon 11)(76-13-1 Freon 113)(75-35-4 11-Dichloroethene )(71-55-6 1,1,1-Trichloroethane )(79-01-6 Trichloroethylene )(127-18-4 Tetrachloroethylene)(126-99-8 Chloroprene) 75-69-45 76-13-15 75-35-4; 71-55-6', 79-01-6? 127-18-4; 126-99-8? 56-23-5? 67-66-3; 75-00-35 75-01-45 75-09-25 75-34-35 75-71-65 78-87-5? 79-00-55 156-59-2 6008 74 SI - CA/093/020474F AU - Scott BR AD - Inhalation Toxicol. Res. Inst., Lovelace Biomed. Environ. Res. Inst., Inc., Albuquerque TI - A new dose-respense model for estimating lifetime tumor risks SO - Annu. Rep. Inhalation Toxicol. Res. Inst. (Lovelace Biomed. Environ. Res. Inst.); 1979,107-10 LA - ENG CD - AITRD AB - CBAC COPYRIGHT: CHEM ABS A tumorgenesis model Is described in which damage to a single intracellular locus can lead to a tumorgenic cellular transformation. Assuming a large no. of independent intracellular loci to be at risk and assuming that damage to a locus sufficient to cause a tumorgenic transformation occurs with probability >0 for all doses >0 leads to the use of the Weibull distribution to characterise the probability of a tumorgenic cellular transformation occurring after exposure to a given dose of carcinogen. The increase in the lifetime tumor incidence above the spontaneous incidence is characterised by a tumor incidence function that represents the probability of occurrence of .gtoreq.l tumorgenic cellular transformations among N(D) independent surviving cells per individual, after exposure to a dose D of carcinogen. The tumor incidence function is fitted to data for the displacement of the tumor incidence above the control incidence after exposure of humans to 226Ra and 228Ra, after long-term oral exposure of animals to dieldrin or RNW 1625 00009961 VCM PAGE 31 # dimethylnitrosamine and after long-term inhalation exposure of animals to vinyl chloride. (60-57-1 DieldrinM62-75-9 Dimethylnitrosamine )(75-01-4 Vinyl chloride) RN - 60-57-1,' 62-75-9; 75-01-4*, 13982-63-3; 15262-20-1 EM - 8008 75 SI - CA/092/202856U AU - Doniger DO TI - The Law and Policy of Toxic Substances Control: A Case Study of Vinyl Chloride SO - 1979,179 pp. LA - ENG CD - BOOKA AB - CBAC COPYRIGHT: CHEM ABS A book. Book vinyl chloride toxicity law RN - 75-01-4 EM - 8007 76 SI AU AU AD TI SO LA CD AB CA/093/0C1946V Bartsrh H ! Sabadie N ; Malaveille C Camus AM Richtei--Reichhelm HB Unit Chem. Carcinog., Int. Agency Res. Cancer, Lyon Carcinogen metabolism with human and experimental animal tissues: inter-individual and species differences Adv. Med. Oncol., Res. Educ. Proc. Int. Cancer Congr., 12th; VOL 3,, 1979,179-87 ENG 42WTA CBAC COPYRIGHT: CHEM ABS Liver fractions obtained from surgery tissue samples of different human subjects were shown to convert vinyl chloride or related haloolefins and several N-nitroso derivs. into alkylating and mutagenic intermediates. (75-01-4 Vinyl chloride) Although large individuai variations were obsd. the av. activity was lower or close to mouse or rat liver fractions. However, with N-nitroso-N'-methylpiperazine, human liver samples were up to 40 times more active than rat liver. When hepatic benzo (a)pyrene hydroxylase (BP hydroxylase) activity in samples from different human subjects was plotted against the liver microsome-mediated mutagenicity, a pos. correlation was obtained between the rates of oxidative BP metab. and mutagenicity in the presence of N-nitrosomorpholine or vinyl chloride as substrate. (16339-07-4 N-Nitroso-N'-methylpiperazine)(9037-52-9 benzo (a)pyrene hydroxylase)(59-89-2 N-Nitrosomorpholine) Therefore, BP hydroxylase activity in normal and tumorous lung tissue from 76 patients with lung tumors was measured. A 60-fold interindividual variation was noted with the rates of BP hydroxylation in tumorous lung tissue lower than in normal tissue of the same patient. When BP hydroxylase activity in the tumorous tissue was plotted vs. the no. of cigarets smoked per day prior to surgery, a neg. correlation was apparent. Thus, differences in carcinogenic metab. may condition in part the response of human individuals when exposed to the same level of m m RNW 1626 I 00009962 VCM PAGE 32 environmental carcinogens. RN - 75-01-9J 16339-07-9J 9037-52-9; 59-89-2; 75-35-9; 100-75-95 126-99-85 593-60-25 769-91-0; 930-55-2 EM - 8007 77 SI - CA/092/185162V TI - Determination of vinyl chloride in gases SO - Neth. Appl. PATENT NO. 78 09595 10/30/79 (Auergesellschaft G. m. b. H. ) LA - DUT AB - CBAC COPYRIGHT: CHEM ABS Thermal hydrolysis of vinyl chloride Cl) at .apprx.580.degree., in the presence of H20 vapor, is const, at 85X (in the 5-50 ppm range) and is used in the detn. of I in gas mixts. (75-01-9 Vinyl chloride) One part of the process-stream sample is thermally hydrolysed at .apprx.580.degree. and the other part at <950.degree.. The hydrolysis products are washed with H20 and the elec, resistances of both aq. solns. are measured. The difference is a direct measure of I. RN - 75-01-9 EM - 8006 78 SI AU AD TI SO LA CD AB RN EM CA/092/185015Z Lee K ; Hansen JL 5 Macauley DC Union Carbide Corp., South Charleston Predictive model of the time-temperature requirements for thermal destruction of dilute organic vapors Proc. Amu. Meet. - Air Pollut. Control Assoc.; VOL 72nd, ISS 1, 1979,Paper No. 79-10.1, 16 pp. ENG PRAPA CBAC COPYRIGHT: CHEM ABS The thermal destruction efficiency of dil. org. vapors using thermal oxidizers is presented. Quant. Kinetics data necessary to design and predict the performance of thermal Oxidizers to assure carcinogenic and other toxic chems. are completely destroyed is used to replace the rule-of-thumb basis. A continuous plug-flow reactor was used to obtain thermal oxidn. kinetics data for compds. of several structural classes. Statistical anal, of the data gives equations that predict the residence time and temp, required to destroy a compd. based solely on mol structure and autoignition temp. The equations present and approach for estg. incineration conditions for a wide variety of compds. with little or no exptl. data. 69-17-55 71-93-2; 79-82-85 79-89-0; 79-85-1; 79-98-65 75-01-95 107-02-65 107-06-25 107-13-15 108-88-35 115-07-15 121-99-85 190-88-55 25167-67-3 8006 1 1 RNW 1627 00009963 VCM PAGE 33 m 79 SI AU AD TI SO LA CD AB RN EM CA/092/184996H Kenson RE Oxy-Catal. Nest Chester Engineered systems for the control of toxic chemical emissions Proc. Annu. Meet. - Air Pollut. Control Assoc.; VOL 72nd, ISS 2, 1979,Paper No. 17.4, 15 pp. ENG PRAPA CBAC COPYRIGHTJ CHEM ABS The design of engineered systems for control of vinyl chloride emissions in PVC plants and for benzene control in petrochem. operations is described. (75-01-4 Vinyl chlori de )( 9002-86-2 PVCM71-43-2 Benzene) Using the engineered systems approach, toxic emission control systems which readily meet stringent emission stds. were developed which are more cost-effective than std. systems. 75-01-4; 9002-86-2; 71-43-2 8006 80 SI AU TI SO LA CD AB RN EM CA/092/184914E Ruiz Alonso C Vinyl chloride, Its harmful effects and analytical control Rev. Fac. Farm. Univ. Cent. Venez.J VOL 44,, 1979,37-64 SPA RFFVA CBAC COPYRIGHT: CHEM ABS The manuf. and uses of poly(vinyl chloride) plastics and air pollution, carcinogenicity, and anal, detection of vinyl chloride by gas chromatog. are reviewed with 18 refs. (9002-86-2 Poly(vinyl chloride))(75-01-4 Vinyl chloride) 9002-86-2; 75-01-4 8006 81 SI CA/092/168373X AU Huebenett F AD E. Merck, Darmstadt TI Experiences in the handling of toxic substances using an emission-free technique so - Ber. Int. Kolloq. Verhuetung Arbeitsunfaellen Berufskr. Chem. Ind.; VOL 6th,, 1979,405-20 LA - GER CD - BIKID AB - CBAC COPYRIGHT: CHEM ABS Emission-free handling of toxic substances is achieved by suitable instrumentation and design, particularly the use of remote control, sep. treatment of offgases and room air in scrubbers, and the use of app. of different sizes. These methods enabled the safe handing of carcinogenic (ClCH2)20 MeSH, and vinyl chloride. (542-88-1 Bis(chloromethyl) ether)(74-93-1 Methanethiol)(75-01-4 Vinyl chloride) The flexibility of the system, used solely in process development, is increased by a suitably equipped lab. and by addnl. portable equipment, e.g. for vacuum generation. RN 542-88-1; 74-93-1; 75-01-4 EM 8006 % m RNW 1628 I 00009964 VCM PAGE 34 62 SI - CA/092/158483U AU - Pessayre D ; Wandscheer JC > Descatoire V ; Dolder A ; Benhamou JP AO - Unite Rech. Physiopathol. Hepat., Hop. Beaujon, Clichy TI - Effects of inducers on the in vivo covalent binding of a vinyl chloride metabolite to liver fractions SO - Biochem. Pharmacol.; VOL 28 ISS 24, 1979>3667-8 LA - ENG CD - BCPCA AB - CBAC COPYRIGHT: CHEM ABS In rats, covalent binding of a metabolite following i.p. Injection of vinyl chloride (I) C500 mumol/kg) by liver microsomal proteins and 100,000 g supernatant proteins was decreased similarly by SKF 525A pretreatment (75 mg/kg, i.p. 15 min before I). (75-01-4 Vinyl chloride) However, pretreatment with DDT (200 mg/kg, i.p.) or phenobarbital (100 mg/kg i.p.) increased in vivo binding to microsomal protein, but not to 100,000 g supernatant proteins. Irreversible binding of vinyl-14C chloride material to liver, blood, kidney, spleen, and muscle was decreased by SKF 525A pretreatment, whereas phenobarbital increased binding in all these organs and DDT increased binding only in liver and muscle. Thus, a compart.uentalized model of vinyl chloride metab. is substantiated. RN - 75-01-4 EM - 8006 83 SI - CA/092/152259D AU - Czernielewski A ; Kiec-Swierczynska M ; Gluszcz M ; Wozniak L AD - Klin. Dermatol., Lodz TI - Pathological skin lesions in workers with long-time exposure to vinyl chloride SO - Przegl. Dermatol.; VOL 66, ISS 5, 1979,463-9 LA - POL CD - PRDEA AB - CBAC COPYRIGHT: CHEM ABS Extensive investigations have shown that histopathol. examn. of skin samples collected from the extremities of workers subjected to long-time exposure to vinyl chloride represents the basic method by which the effects of such exposure can be detd. (75-01-4 Vinyl chloride) Histol. skin changes seem to be the earliest symptoms of chronic poisoning caused by the toxicity of vinyl chloride, and they can be recognized before any clin. symptoms become noticeable. RN - 75-01-4 EM - 8005 84 SI - CA/092/152256A AU - Jedrychowski M ; Prochowska K ; Garlinska J ; Bruzgielewicz J AD - Inst. Med. Spolecznej, Akad. Med., Krakow TI - Occurrence of chronic nonspecific diseases of the respiratory tract in workers of a vinyl resin plant SO - Przegl. Lek.; VOL 36, ISS 9, 1979,679-82 LA - POL CD - PRLKA AB - CBAC COPYRIGHT: CHEM ABS In a vinyl resin plant 456 workers RNW 1629 00009965 VCM PAGE 35 (313 men and 143 women) were examd. for the presence of chronic nonspecific diseases of the respiratory tract (CNDRT). Although the percentage of chronic bronchitis was higher in the vinyl chloride (I) and vinyl acetate (II) departments* and the fast respiratory vol. in 1 s index in groups of workers employed in the II polymer department was significantly different from that found in workers employed in the I-II copolymer department* the relation between the occurrence of CNDRT and the work-environment concns. of I and II remains an open question. (75-01-4 Vinyl chloride)(108-05-4 Vinyl acetate)(9003-20-7 Polyvinyl acetate)(9003-22-9 Vinyl chloride-vinyl acetate copolymer) Since acetaldehyde* MeOH* and NH3 are also present in the departments investigated* it is possible that the combined effect of all the above compds. results in damage to the lung function and facilitates the occurrence of CNDRT. (75-07-0 Acetaldehyde)(67-56-1 Methanol) RN - 75-01-4; 108-05-4? 9003-20-7; 9003-22-9; 75-07-0; 67-56-1; 7664-41-7 EM - 8005 85 SI - CA/092/152102X AU - Sadowski S ; Strusinski A AD - Zakl. Hig. Komunalnej Panstw. Zakl. Hig.* Warsaw TI - Determination of low concentrations of vinyl chloride in air SO - Rocz. Panstw. Zakl. Hig.; VOL 30, ISS 4, 1979,413-19 LA - POL CO - RPZHA AB - CBAC COPYRIGHT: CHEM ABS The method is based on adsorption of vinyl chloride on activated charcoal with subsequent desorption by CS2. (75-01-4 Vinyl chloride) The vinyl chloride is detd. by gas chromatog. applying a flame-ionization detector. The lowest amt. of vinyl chloride which could be detd. in this way was 0.1 ng. RN - 75-01-4 EM - 8005 86 SI - CA/092/134672D AU - Benson JS AD - B. F. Goodrich Chem. Div.* Cleveland TI - Catoxid for chlorinated byproducts SO - Hydrocarbon Process.; VOL 58, ISS 10* Sect. 1* 1979*107-8 LA - ENG CD - HYPRA AB - CBAC COPYRIGHT: CHEM ABS Chlorinated hydrocarbon wastes, from the vinyl chloride plant* are oxidized by air in a fluidized bed catalytic reactor at <1000.degree.F. (75-01-4 Vinyl chloride) The reactor effluent contains HC1 H20, N* O* and C oxides. Heat of combustion is recovered by circulating boiler-feed water throuqh coils in the fluidized bed. RN - 75-01-4*, 7647-01-0 EM - 8005 RNW 1630 I 00009966 VCM PAGE 36 87 SI AU AU AD TI SO LA CD AB RN EM 88 SI AU AU AD TI SO LA CD AB RN EM SI AU AU AD TI SO LA CD AB CA/092/134520C Mizerski J J Wedrychowicz A ; Maslanka-Kowalczyk D 5 Pi tuch A Labza H Inst. Pediat., Akad. Med., Krakow Immunological studies of workers exposed to vinyl chloride Przegl. lek.J VOL 36, ISS 9, 1979,665-8 POL PRLKA CBAC COPYRIGHT: CHEM ABS Studies of certain immunol. indicators in workers exposed to vinyl chloride disclosed increased levels of IgA and T lymphocyte nos., both relative and abs.j this was particularly noticeable in workers handling the ccpolymn. process. (75-01-4 Vinyl chloride) The pathol. and cl in. significance of the above findings is discussed. 75-01-4 8005 CA/092/134519J Milkowski A J Kiec E j Banak D 5 Wedrychowicz A 5 Popiela T Koscielny I Akad. Med., Krakow Vascular alterations in workers exposed to vinyl chloride Przegl. Lek.J VOL 36, ISS 9, 1979,661-4 POL PRLKA CBAC COPYRIGHT: CHEM ABS Examn. of 34 workers whose jobs exposed them to the action of vinyl chloride involved such tests as skin thermometry and photoplethysmog., combined with the hand cooling and pressure test. (75-01-4 Vinyl chloride) In addn. the rate of pulse wave propagation in the aorta and the upper right extremity was detd. Photoplethysmog. functional changes were obsd. in all subjects studied. In 89/C of the examd. workers skin thermometry revealed a prolongation of the recovery time, 73/C showed an increase rate of pulse wave propagation in the upper right extremity, and 50/C in the aorta. 75-01-4 8005 CA/092/134518H Popiela T J Szybinski Z J Wedrychowicz A J Huszno B J Stachura J Dura K J Billewicz O Akad. Med., Krakow Results of clinical studies in workers exposed to vinyl chloride Przegl. Lek.J VOL 36, ISS 9, 1979,651-60 POL PRLKA CBAC COPYRIGHT: CHEM ABS Cl in. examn. of 30 of the 168 subjects, whose work exposed them to the toxic effects of vinyl chloride, involved such tests as scintigraphy of the liver, selective arteriog. of the liver artery, reverse cholangiopancreatog., and biopsy of the liver. (75-01-4 Vinyl chloride) Neither scintigraphic nor histol. or histochem. m RNW 1631 00009967 VCM PAGE 37 changes of the liver paralleled the biochem. changes disclosed by specific tests. Among the biochem. tests, the most useful proved to be the bromosulfophthalein test and the detn. of the alk. phosphatase level in the serum. (9001-78-9 Alk. phosphatase) Scintigraphy of the liver is considered to be useful as a screening test only. RN - 75-01-95 9001-78-9 EM - 8005 90 SI AU AD TI SO LA CD AB RN EM CA/092/139517G Ssybinski 2 5 Popiela T Klin. Endokrynol. Przem. Mater., Akad. Med., Krakow Principles of a multistage research program on the toxic effects of vinyl chloride and mercury vapors Przegl. Lek.5 VOL 36, ISS 9,'1979,695-9 POL PRLKA CBAC COFYRIGHT: CHEM ABS A no. of biochem. and clin. tests were conducted on 168 subjects engaged in the prodn. and polymn. of vinyl chloride and on 236 subjects, whose involvement in the prodr,, of Cl2 (by the electrolysis of NaCl) and of acetaldehyde caused them to be exposed to Hg vapors. (75-01-9 Vinyl chloride)(75-07-0 Acetaldehyde) The purpose of this study has been to det. the extent to which the workers suffered from the exposure to the toxic effects of vinyl chloride or of Hg vapors and tc develop some basic measures for the prevention of such harmful exposure. 75-01-95 75-07-05 7939-97-65 7782-50-5 8005 91 SI AU AD TI SO LA CD AB RN CA/092/123080H Lutz WK 5 Schlatter C Inst. Toxicol., Univ. Zurich, Schwerzenbach In vivo covalent binding of chemicals to DNA as a short-term test for careinogenicity Arch. Toxicol.5 ISS Suppl. 2, 1979,911-15 ENG ARTOD CBAC COPYRIGHT: CHEM ABS The detn. of covalent binding of radioactive chems. to DNA in intact mammalian organisms is proposed as a short-term test for carcinogenicity. The effectiveness of covalent binding to rat liver DNA correlated well with the hepatocarcinogenicity detected in long-term bioassays. The binding indexes ranged over more than five orders of magnitude between that of the strongest hepatocareinogen tested, aflatoxin B1 (I), and the limit of detection of binding with 100 muCi 19C-labeled chems. (1162-65-8 aflatoxin B1) The order of magnitude of binding was therefore a good quant, measure for carcinogenicity. The pattern of DNA binding sites was important, esp. for small alkylating agents where the detn. of total binding might indicate a higher carcinogenic potency than was actually obsd. 1162-65-85 50-32-85 51-79-65 53-16-75 53-96-35 57-63-65 60-11-75 RNW 1632 I # % 00009968 VCM PAGE 38 62-75-9; 71-93-25 75-01-9; 81-07-2J 108-88-3; 930-55-2J 6795-23-9 EM - 8005 92 SI - CA/092/122911T AU - Krahn DF AD - Haskell Lab. Toxicol. Ind. Med.* E. I. du Pont de Nemours and Co. Wilmington TI - Utilization of the CHO/HGPRT system: metabolic activation and method for testing gases SO - Banbury Rep.; VOL 2* ISS Mamm. Cell Mutagen.: Maturation Test Syst., 1979,251-61 LA - ENG CD - BANRD AB - CBAC COPYRIGHT: CHEM ABS After detg. the reproducibility and sensitivity of the CHO/HGPRT system using known mutagens and the storage stability of the S-9 fraction, the system was used to det. the mutagenic activity of gases and volatile liqs. Vinyl chloride was cytotoxic and mutagenic in the system when S-9 activation was included. (75-01-9 Vinyl chloride) The activation system had no effect on chlorofluoromethane mutagenic activity. (593-70-9 chlorofluoromethane) Freon 11 and Freon 12 were not mutagenic in the presence or absence of the activation system. (75-69-9 Freon 11)(75-71-8 Freon 12) The results obtained with gases and volatile liqs. using this system were comparable with results obtained using other systems. RN - 75-01-9; 593-70-9; 75-69-95 75-71-85 62-75-9 EM - 8005 93 SI - CA/092/122836X AU - Dessy E ; Spinazzola A 5 Bucarelli A ; Tagarelli G ; Faa G AD - Univ. Cagliari, Cagliari TI - First results of studies on the effects of vinyl chloride on rats kept in an industrial atmosphere for controlled time periods SO - G. Ital. Med. Lav.; VOL 1, ISS 2, 1979,83-6 LA - ITA CD - GIMLD AB - CBAC COPYRIGHT: CHEM ABS Rats exposed to vinyl chloride in a human work environment at the same h in which workers are exposed showed morphol. alterations of organs particularly the liver, kidnevs, and spleen. (75-01-9 Vinyl chloride) Implications of these findings to workers exposed to vinyl chloride at concns. considered safe are discussed. RN - 75-01-9 EM - 8005 99 SI - CA/091/103989U AU - Harrison EA TI - Toxicity of Vinyl Chloride. (A Bibliography with Abstracts) SO - 1979,91 pp. LA - ENG CD - BOOKA AB - CBAC COPYRIGHT: CHEM ABS A book Vinyl chloride toxicity book RN - 75-01-9 RNW 1633 00009969 VCM PAGE 39 EM - 7910 95 SI AU AD TI SO LA CD AB RN EM CA/09jl v' ^906R Gideon jA Cent. Dis. Control* Natl. Inst. Occup. Saf. Health, Cincinnati Engineering control technology in polyvinyl chloride polymerization plants J. Environ. Pathol. Toxicol.; VOL 2, ISS 5, 1979,285-318 ENG JEPTD CBAC COPYRIGHT: CHEM ABS A discussion is given on control of vinvl chloride pollution of the air of plants where PVC is manufd. (75-01-9 Vinyl chloride)(9002-86-2 PVC) 75-01-9*, 9002-86-2 7909 96 SI - CA/091/078393D AU - Kucerova M ; Polivkova Z 5 Batora J AD - Pediatr. Dep. Postgrad. Med. Inst., Prague TI - Comparative evaluation of the frequency of chromosomal aberrations and the sister-chromatid exchange (SCE) numbers in peripheral lymphocytes of workers occupationally exposed to vinyl chloride monomer SO - Mutat. Res.; VOL 67, ISS 1, 1979,97-100 LA - ENG CD - MUREA AB - CBAC COPYRIGHT: CHEM ABS Comparison of data on 9 workers exposed to vinyl chloride (I) indicates that routine chromosomal aberrations and SCE nos. are equally suitable for testing of high-dose I mutagenicity in vivo. (75-01-9 Vinyl chloride) RN - 75-01-9 EM - 7909 97 SI - CA/091/069719N AU - Hultmark D ; Sundh K ; Johansson L ; Arrhenius E AD - Wallenberg Lab., Stockholm Univ., Stockholm TI - Ethanol inhibition of vinyl chloride metabolism in isolated rat hepatocytes SO - Chem.-Biol. Interact.; VOL 25, ISS 1, 1979,1-6 LA - ENG CD - CBINA AB - CBAC COPYRIGHT: CHEM ABS Isolated rat liver cells converted 19C-labeled vinyl chloride (I) into nonvolatile metabolites. (75-01-9 Vinyl chloride) This metab. was not increased by in vivo pretreatment with phenobarbital. It was sensitive to inhibition by EtOH, which, at a concn. of 9 mM* inhibited I metab. to 50/i in hepatocyte suspensions. (69-17-5 Ethanol) The metabolic activity was NADPH-dependent and was localized in the microsomal fraction of the liver. The enzyme was also strongly inhibited by tetrahydrofuran, indicating that it could be identical to an EtOH-inducible cytochrome P 950 species. (109-99-9 Tetrahydrofuran)(9035-51-2 cytochrome P 950) RN - 75-01-9; 69-17-5; 109-99-9; 9035-51-2 RNW 1634 00009970 VCM PAGE 40 EM - 7909 98 SI - CA/091/069374W AU - Frejaville JP 5 Beaune P ; Cresteil T AD - Dep. Anesthes1ol. Hop. Necker, Paris TI - Metabolism of chloroethylenes SO - Arch. Mai. Prof. Med. Trav'. Secur. Soc.? VOL 40* ISS 1-2* 1979,359-64 LA - FRE CD - AMPMA AB - CBAC COPYRIGHT: CHEM ABS A review with 4 refs, on the metab. of chlorinated derivs. of ethylene and in particular, of the biotransformation and toxicity of trichloroethylene and vinyl chloride. (79-01-6 Trichloroethylene)(75-01-4 Vinyl chloride) RN - 79-01-6J 75-01-4J 74-85-1 EM - 7909 99 SI - CA/091/061896X AU - Zolkin GA AD - Vses. Nauchno-Issled. Inst. Tr. Stroit.* Moscow TI - Hygienic assessment of the high-temperature treatment of polytvinyl chloride) finishing materials SO -Gig. Sanit.; ISS 4, 1979,76-7 LA - RUS CD - GISAA AB - CBAC COPYRIGHT: CHEM ABS The atm. surrounding workers employed in welding PVC linoleum averaged above the permissible concns. of CH2:CHCl and di-Bu phthalate. (9002-86-2 PVCM75-01-4 Vinyl chlorideH84-74-2 Dibutyl phthalate) This was true for both processes studied, IR heating and direct contact with hot electrodes. RN - 9002-86-2; 75-01-4; 84-74-2 EM - 7908 100 SI - CA/091/322798M AU - Brunei* ett RB ; Colvin M ; White EH ; McKee J ? Hartman PE AU - Brown Du AD - Dep. C*v____ Johns Hopkins Univ., Baltimore TI - Compo' i. .i, of mutagenicity, antitumor activity, and chemical proper e: of selected nitrosoureas and nitrosoamides SO - Cancer .-s. J VOL 39, ISS 4, 1979,1328-33 LA - ENG CD - CNREA AB - CBAC COPYRIGHT: CHEM ABS Nitroureas and nitrosoamides were compared with respect to mutagenicity for Salmonella typhimurium* in vitro cytotoxicity, in vitro toxicity and antitumor activity against murine leukemia, and chem. properties. Despite chem. similarities between the nitroureas and nitrosoamides, they showed important differences in biol. activity. Some of the nitrosoureas were very active antitumor agents, and less mutagenic than the corresponding nitrosoamides, which lacked antitumor activity. RN - 67-56-15 75-01-4; 75-07-0? 79-20-9? 107-06-2? 107-07-3? 154-93-8? RNW 1635 00009971 VCM PAGE 41 542-58-5; 627-06-5; 684-93-5; 816-57-9; 1118-69-0; 2365-30-2; 5211-42-75 5331-48-6? 7355-58-05 7417-67-6; 13010-20-35 51834-70-95 64057-51-8; 67809-15-85 70636-67-85 70636-68-95 70636-69-0 EM - 7908 101 SI AU AD TI SO LA CD AB RN EM CA/090/209572R Lubyanskii ML 5 Levina MM 5 Gronsberg ES 5 Mikhno VB Gor'k. Nauchno-Issled. Inst. Gig. Tr. Profzabol. Minist. Zdravookhr., Gorkiy > USSR Hygienic assessment of the fire detoxication of wastes from dichloroethane and vinyl chloride production Gig. Sanit.5 ISS 3, 1979,61-3 RUS GISAA CBAC COPYRIGHT; CHEM ABS The wastes are burned at 1150-1250.degree. and the stack gases scrubbed with HCl soln. and then water. The reclaimed HCl is reused. No CC14, CHC13, or COC12 are present in the final emissions, but 116 kg C12 and 98.5 kg HCl are emitted/day. It is recommended that the stack gases be scrubbed with Ca(0H)2 to reduce these amts. 75-01-45 1300-21-65 1305-62-05 7647-01-05 7782-50-5 7907 102 SI - CA/090/209274V AU - Sudo Y 5 Oshima E AD - Dep. Ind. Chern., Tokyo Natl. Tech. Coll., Hachioji, Japan TI - Pyrolysis rate of vinyl chloride monomer 00009979 VCM PAGE 49 121 SI - CA/092/046581T AU - Harsch OE Cronn OR 5 Slater WR AO - Dep. Chew. Eng., Washington State Univ., Pullman TI - Expanded list of halogenated hydrocarbons measurable in ambient air SO - J. Air Pollut. Control Assoc.5 VOL 29, ISS 9, 1979,975-6 LA - ENG CD - JPCAA AB - CBAC COPYRIGHT! CHEM ABS Addnl. halocarbon compds. which can be measured in ambient air samples by the freeze-out concn. method are listed with other hydrocarbons Known to be present in the atm. Retention times and detection limits of these hydrocarbons are given. Among these halogenated hydrocarbons were: Mel, cis-C2H2Cl2, l2-C2H4Br2 CHBr3, and CBr4. (74-88-4 Methyl iodide )(156-59-2 cis-Dichloroethylene )(106-93-4 1,2-Dibromoethane)(74-95-3 Dibromo methane )(558-13-4 Tetrabromomethane) RN - 74-88-4J 156-59-2; 106-93-4; 74-95-3; 558-13-4; 56-23-5; 67-66-3; 71-55-6J 74-83-9? 74-87-3; 75-00-3; 75-01-4; 75-09-2; 75-43-45 75-69-4J 75-71-85 76-13-15 76-14-2J 79-01-65 107-06-2; 127-18-45 557-91-5J 590-11-4 EM - 8002 122 SI - CA/092/046483N AU - Infante PF AD - Cent. Dis. Control, Natl. Inst. Occup. Saf. Health, Cincinnati TI - Epidemiologic approaches for surveillance of genetic hazards with particular reference to anesthetic gases SO - Genet. Damage Man Caused Environ. Agents, CProc. Conf.]5 1979,289-300 LA - ENG CD - 41RGA AB - CBAC COPYRIGHT: CHEM ABS A review and discussion with 19 refs, of mutagenic effects of waste anesthetic gases, vinyl chloride, and chloroprene. (75-01-4 Vinyl chloride )(126-99-8 Chloroprene ) RN - 75-01-45 126-99-8 EM - 8002 123 SI - CA/092/027646B AU - Sebestyen NA 5 Thompson WB AD - Perkin-Elmer Corp., Norwalk TI - The determination of vinyl chloride monomer in charcoal-loaded personnel monitor tubes using the automated gas chromatographic head space technique SO - Chromatogr. News 1.5 VOL 7, ISS 2, 1979,29-30 LA - ENG CD - CHNLA AB - CBAC COPYRIGHT: CHEM ABS The head space method described herein is a simple and accurate, totally automated, way to det. vinyl chloride which has been adsorbed in a personnel monitor collection tube contg. activated charcoal. (75-01-4 vinyl chloride) The relatively short anal, cycle time (6 min) and RNW 1644 00009980 VCM PAGE 50 relative accuracy (.apprx.2X) will allow for a high throughput (over 200 samples day) of accurate results. RN - 75-01-4 EM - 8002 124 SI - CA/092/028382Z AU - Watson JR ; Lawrence RC > Lovering EG AD - Pharm. Chem. Div., Drug Res. Lab., Ottawa TI - A qas chromatographic (GC) headspace method for monitoring vinyl chloride in liquid drug and cosmetic products SO - Can. J. Pharm. Sci.J VOL 14, ISS 3, 1979,57-60 LA - ENG CD - CNJPA AB - CBAC COPYRIGHT: CHEM ABS A gas chromatog. method is described for monitoring vinyl chloride levels in liq. drug and cosmetic prepns. packaged in poly(vinyl chloride) containers. (75-01-4 Vinyl chloride )(9002-86-2 Poly(vinyl chloride)) A weighed aliquot of the com. product in a tightly septum-sealed vial with accurately known headspace vol. is heated to 50.degree, for 30 min. A portion of the warm headspace gas is then injected into a gas chromatog. equipped with a flame ionisation detector and a styrene-divinylbenzene porous polymer column. The vinyl chloride is eluted isothermally at 125.degree, and is quantitated by simple computation relative to a response factor detd. daily using a std. vinyl chloride-air calibration gas mixt. The procedure was subjected to collaborative study by 5 analysts. Two mouthwash products, 2 com. shampoos, 2 large vol. parenteral solns. and 2 baby oil prepns. were analyzed. Statistical evaluation of the results of the study showed that the method had an overall coeff. of variation of about 17X. The limit of detectability of the procedure is about 0.1 ppb in the sample soln. RN - 75-01-4 5 9002-86-2 EM - 8002 R|S|W 1644 1 00009981 VCM PAGE 51 127 SI - CA/092/010981W AU - Roosken AA li AD - Dienst Cent. Milieubeheer Rijnmond* Schiedam Ti - Measurement of organic gases in the atmosphere SO - PT-Procestech.; VOL 39* ISS 7* 1979*909-15 LA - DUT CD - PTPTB .. AB - CBAC COPYRIGHT: CHEM ABS Various measuring methods are discussed. The identification of sep. components offer problems. The best procedure is a combination of mass spectrometry and capillary gas chromatog. RN - 71-93-2J 79-98-6; 75-01-9; 107-13-1 EM - 8001 RNW 1644.2 00009982 VCM PAGE 52 128 SI - CA/091/198029M AU - Lee K ; Jahnes HJ 5 Macauley DC AD - Chem. Plast. Div. Union Carbide Corp.* South Charleston TI - Thermal oxidation kinetics of selected organic compounds 50 - J. Air Pollut. Control Assoc.; VOL 29, ISS 7, 1979,799-51 LA - ENG CD - JPCAA AB - CBAC COPYRIGHT: CHEM ABS The Incineration of vinyl chloride, Et acrylate, acrolein, and benzene (100, 500, and 1000 ppm in air) at 800-1500.degree.F for 0.1-2 s was studied to det. the fundamental time-temp, relations for different chems. at low oxidn. temps, in the absence of flame-generated free radicals. (75-01-9 Vinyl chloride)(190-88-5 Ethyl acrylate )(107-02-8 Acrolein)(71-93-2 Benzene) RN - 75-01-95 190-88-55 107-02-8; 71-93-2 EM - 8001 129 51 - CA/091/205275U AU - Feron VJ 5 Kruysse A ; Til HP AD - Cent. Inst. Nutr. Food Res., TNO, Zeist TI - One-year time sequence inhalation toxicity study of vinyl chloride in rats. 1. Growth, mortality, hematology, clinical chemistry and organ weights SO - Toxicology; VOL 13, ISS 1, 1979,25-8 LA - ENG CD - TXCYA AB - CBAC COPYRIGHT: CHEM ABS Wistar rats were exposed to atmospheres contg. 0 (control) or 5000 ppm vinyl chloride monomer (VCM), 7 h/day, 5 days/wk, for a period of 52 wk. (75-01-9 Vinyl chloride) After 9, 13, 26, and 52 wk, 10 rats/sex/group were killed and subjected to extensive examns. as to growth, mortality, hematol., clin. chem., and organ wts. Slight growth retardation throughout the exptl. period and high mortality in the 2nd half of the study were obsd. in VCM-exposed animals. Some of the hematol. parameters and biochem. blood parameters were influenced by VCM after an exptl. period of 52 wk only. Blood clotting time was shorter in VCM-exposed rats than in controls. There were minor indications of increased K contents of the blood serum in VCM-exposed animals during the 1st half of the test period. The kidneys were adversely affected by VCM as indicated by increased blood urea N levels and relative kidney wts. After 52 wk, increased wts. of heart and spleen, and slight signs of anemia were noticed in VCM-exposed rats. The present study did not produce suitable parameters for early diagnosis of VCM-disease in man. RN - 75-01-95 7990-09-7 DTG - CHRONIC TOXIC DOSE EM - 8001 RNW 1645 00009983 VCM PAGE 53 130 SI AU TI SO LA AB RN EM CA/091/ lo(713V Schmidt 6L ; Jewett GL ; Melcher RG ; Wessling RA Prolonging the breakthrough of volatile substances through adsorbent-containing air purifying devices Can. PATENT NO. 1055405 05/29/79 (Dow Chemical Co.) ENG CBAC COPYRIGHTS CHEM ABS Volatile org. vapors are adsorbed on activated C in gas masks and chem, cartridge respirators. The activated C (Saran C) is prepd. from cryst. vinylidene chloride polymer and has surface area of 900-1400 m2/g. Thus> air contg. vinylidene chloride 35.5 and vinyl chloride 50 ppm was passed through a Saran C column (inside diam. 1/4 in. and 7 cm-thick bed)* and complete retention of vinylidene chloride and 4V. breakthrough of vinyl chloride was obsd. for 0.5 L/min after 6 h. (75-35-4 Vinylidene chloride)(75-01-4 Vinyl chloride) 75-35-4; 75-01-4? 74-97-55 75-25-2; 7440-44-0; 25429-23-6 7912 131 SI - CA/091/180665F AU - Fomenko VNi Zaeva GN > Katosova LD 5Pavlenko GI TI - Results ofa study of oncologicalmorbidityand cytogenetic effects in workers occupied in processes for polymerising vinyl chloride SO - Toksikol. Nov. Prom. Khim. Veshchestv, (Moskva); ISS 15* 1979,17-21 LA - RUS CD - D4J0U AB - CBAC COPYRIGHT: CHEM ABS Title only translated. Vinyl chloride occupational exposure cancer Cytogenetics vinyl chloride occupational exposure RN - 75-01-45 9002-86-2 EM - 7912 132 SI - CA/091/180628N AU - Montalvo JG Jr AD - Gulf South Res. Inst.* New Orleans TI - Error estimates in total organic elemental content passive personal samplers SO - NBS Spec. Publ. (U. S.)5 VOL 519, ISS Trace Org. Anal.: New Front. Anal. Chem.* 1979*747-52 LA - ENG CD - XNBSA AB - CBAC COPYRIGHT: CHEM ABS Equations were derived and a protocol suggested for computing the ambient concn.-error attributed to the mol. diffusion approxn. for total elemental content passive-personal samplers. An example was described for a total org. Cl passive-sampler at a vinyl chloride plant in relation to carcinogenesis correlation. The samples need not be restricted to total org. Cl, but could include total org. Br, total arom. amines* etc. RN - 75-01-4J 7440-44-0 EM - 7912 RNW 1646 00009984 VCM PAGE 54 133 SI AU TI SO LA CD AB RN EM - CA/091/180599N - Diehl W ; Gellendin D > Grambow L ; HunekeKH 5Zwintsscher H - Toxiwarn - a portablemeasuring and warningapparatus fortoxic gases - Draegerheft; VOL 313,, 1979,2-16 - GER - DRAEA - CBAC COPYRIGHT! CHEM ABS The construction and operation of Toxiwarn, as app. employing the Toxicator cassette (giving a color reaction on flexible tape) to indicate the presence of toxic concns. of gases (C2H3C1, Cl, HCN, H2S, COC12) are described. (75-01-4 Vinyl chloride)(75-44-5 Phosgene) - 75-01-4J 75-44-55 74-90-8; 7782-50-5; 7783-06-4 - 7912 134 SI AU AD TI SO LA CD AB RN EM CA/091/152364P Sharma RP ; Gehring PJ Toxicol. Program, Utah State Univ., Logan Immunologic effects of vinyl chloride in mice Ann. N. Y. Acad. Sci.J VOL 320,, 1979,551-63 ENG ANYAA CBAC COPYRIGHT! CHEM ABS Mice were exposed to 10-1000 ppm vinyl chloride (VC) for 2-8 wk 6 h/day, 5 days/wk. (75-01-4 Vinyl chloride) A slight increase in the spleen wt. of mice was noted at the highest exposure level. Spleens were obtained from these animals (4 mice/group after 2, 4, and 8 wk of exposure) and their lymphocytes cultured in vitro with or without the presence of phytomitogens, phytohemagglutinin (PHA) and pokeweed mitogen (PWM). Relative blast formation and the DNA synthesis was measured by the incorporation of 3H-labeled thymidine in the cultured cells. The response of splenic lymphocytes to the phytomitogens was increased several-fold by VC exposure. The effects were apparent at 1000 ppm VC after 2 wk of exposure and at all levels of VC exposure after 4-8 wk. The effects were generally more pronounced at 100 ppm VC exposure than those at 1000 ppm. In vitro culture of splenic lymphocytes from control or VC-exposed mice in the VC atm. did not show an enhancement of blast formation. Alteration of VC metab. during the VC exposure in vivo yielded results that indicated that metabolites of VC may be responsible for the stimulation of lymphocyte transformation obsd. in splenic cultures. 75-01-4 7912 RNW 1647 00009985 VCM PAGE 55 135 SI - CA/091/151529J AU - Weinkam RJ ? Lin H AD - Sch. Pharm., Univ. California* San Francisco TI - Reactions of 1>3-bis(2-chloroethyl)-l-nitrosourea and l-(2-chloroethyl )-3-cyclohexyl-l-nitrosourea in aqueous solution SO - J. Mad. Chem.? VOL 22, ISS 10, 1979,1193-8 LA - ENG CD - JMCMA AB - CBAC COPYRIGHT! CHEM ABS The products formed during decompn. of the title compds., BCNU and CCNU, in neutral aq. soln. accounted for 75-80'/. of the starting material. (159-93-8 BCNUM13010-97-9 CCNU) Most of the products were formed from an an initial cleavage of the nitrosourea, whereas some were formed from denitrosation of the nitrosourea. The relation of these products to the active form of the alkylating agents is discussed. RN - 159-93-8J 13010-97-9; 75-01-9; 75-07-0? 107-07-3? 108-91-8? 997-25-6; 689-98-5? 2219-72-9? 2387-23-7? 10002-37-6? 13908-11-7? 15938-70-7? 71353-16-7? 71353-17-8? 71979-93-1 EM - 7912 136 SI - CA/093/216922G AU - Buchter A ? Bolt HM ? Filser J ? Goergens HN ? Laib RJ ? Bolt M AD - Inst. Poliklin. Arbeits- Sosialmed., Univ. Koeln, Cologne TI - Pharmacokinetics and carcinogenesis of vinyl chloride. Laboratory medicine risk evaluation SO - Moeglichkeiten Grensen Biol. Monit./Arbeitsmed. Probl. Dienstleitungsgewerbes/Arbeitsmed. Kolloq., B? 1978,111-29 LA - GER CD - 99JJA AB - CBAC COPYRIGHT: CHEM ABS Half-life time of inhaled vinyl chloride in rats, rabbits, mice, Mericnes unguiculatus, and 2 persons weighing 63 and 83 kg were 67.8, 277, 99, 193, 18, and 20.5 min, resp. (75-01-9 Vinyl chloride) The clearance rate was 8.9, 2.79, 25.6, 12.98, 1.79, and 2.93 L/h/kg. Within 1 min of vinyl chloride inhalation, the vinyl chloride concn. in the breath of the test persons reached 70-9X of the final concn., indicating an extremely rapid intake and spread in the body. The metabolic elimination of vinyl chloride involves formation of a carcinogenic epoxide. RN - 75-01-9 EM - 8101 137 SI - CA/093/100759T AU - Goryacheva LA ? Stulova EA TI - Comparative data of a study of nervous activity mediators in patients with chronic vinyl chloride and tetraethyllead poisoning SO - Aktual'n. Vopr. Gigieny i Profpatol. v Nekotor. Otrasl. Khim. Prom-sti, M.? 1978,63-5 LA - RUS CD - D3RAP AB - CBAC COPYRIGHT: CHEM ABS Title only translated. Nervous system chloroethane tetraethyllead poisoning Vinyl chloride poisoning RNW 1648 00009986 VCM PAGE 56 nervous system Tetraethyllead chronic poisoning nervous system Occupational poisoning chronic chloroethene tetraethyllead RN - 75-01-9J 78-00-2 EM - 8009 138 SI - CA/093/078793J AU - Guerra ON ; Kronoveter KJ AD - Ellis Fischel State Cancer Hosp. Columbia TI - Vinyl chloride concentrations in maxillofacial prosthetics laboratories SO - J. Prosthet. Dent.; VOL 39, ISS 2, 1978,200-2 LA - ENG CD - JPDEA 1 AB - CBAC COPYRIGHT! CHEM ABS Time-weighted av. exposures of technicians in 3 maxillofacial prosthetics labs were <0.1 ppm vinyl chloride; the US std. exposure limit is 1 ppm averaged over an 8-h period. (75-01-9 Vinyl chloride) RN - 75-01-9 EM - 8009 139 SI - CA/092/202650X AU - Scheil GW ; Sharp MC AO - Midwest Res. Inst., Kansas City TI - Collaborative testing of EPA method 106 (vinyl chloride) that will provide for a standardised stationary source emission measurement method SO - Report; ISS EPA/600/9-78/058J Order No. PB-298775,, 1978,70 pp. LA - ENG CD - D8REP AB - CBAC COPYRIGHT: CHEM ABS Round-robin anal, of std. vinyl chloride (I) samples, with and without potentially interfering compds. showed that Chromosorb 102/SF-96 columns performed better when AcH was present, but Chromosorb 102 alone was better when Me3CH was present. (75-01-9 Vinyl chloride) Operator bias averaged 0.18 ppm low, and std. deviation was 0.72 ppm. Peak height and area measurements gave similar results, the bias resulted entirely from Chromosorb 102 and not from Chromosorb 102/SF-96 columns. RN - 75-01-9 EM - 8007 190 SI - CA/092/192901A AU - Doniger OD TI - The Law and Policy of Toxic Substances Control: A Case Study of Vinyl Chloride SO - 1978,180 pp. LA - ENG CD - BOOKA AB - CBAC COPYRIGHT: CHEM ABS A book Book vinyl chloride control RN - 75-01-9 EM - 8007 RNW 1649 00009987 VCM PAGE 57 141 SI - CA/092/134392N AU - Herget WF ; Brasher JD AD - Environ. Res. Cent.* EPA* Research Triangle Park TI - Remote measurement of atmospheric pollutants by infrared absorption and emission spectroscopy 50 - Top. Meet. Atmos. Spectrosc.* Dig Tech. Pap.; 1978>ThA5/l-ThA5/4 LA - ENG CD - 42HDA AB - CBAC COPYRIGHT! CHEM ABS The Remote Optical Sensing of Emissions (ROSE) system uas installed in a van for use with a remote light source for absorption measurements of gaseous pollutants over path lengths of .apprx.l km near a pollutant source or for use in a single-ended mode to obtain emission spectra of gases exiting industrial stacks at elevated temps. The system was used to det.* e.g. propylene and C2H4 near an oil refinery and to det. the efficiency of a flare in combusting vinyl chloride. (115-07-1 Propylene )(74-85-1 Ethylene )(75-01-4 Vinyl chloride) RN - 115-07-1; 74-85-1*, 75-01-4 EM - 8005 142 51 - CA/092/115622W AU - Lee K ; Jahnes HJ ; Macauley DC AD - Union Carbide Corp.* South Charleston TI - Thermal oxidation kinetics of selected organic compounds SO - Proc.* Annu. Meet. - Air Pollut. Control Assoc.; VOL 71st. Vol. 4>> 1978*Paper No. 58.6* 16 pp. LA - ENG CD - PRAPA AB - CBAC COPYRIGHT: CHEM ABS A plug-flow system was developed to obtain medium-temp, thermal destruction rate data for dil. fumes without flame generated free radicals. Empirical 1st order kinetic equations were obtained for the destruction rate data for vinyl chloride (I)> Et acrylate* acrolein, and C6H6. (75-01-4 Vinyl chloride)(140-88-5 Ethyl acrylate)(107-02-8 Acrolein)'71-43-2 Benzene) The destruction rate for C6H6 and I were highly temp.-sensitive* as indicated by their high activation energies (99.6 and 63.3 kcal/g-mole, resp.). A thermal oxidizer designed to operate at 0.5 s residence time would require for 99.9'/. destruction, a temp, of 1400.degree. F for vinyl chloride* 1380.degree. F for C6H6* 1160.degree. F for Et acrylate, and 1090.degree. F for acrolein. RN - 75-01-45 140-88-5; 107-02-8; 71-43-2 EM - 8004 RNW 1650 00009988 VCM PAGE 58 143 SI - CA/092/081459F AU - Milby TH AD - SRI Int. Menlo Park TI - Vinyl chloride - an information resource SO - Report; ISS NIH-78/1599, DHEW/PUB/NIH-78/1599; Order No. HRP-0028012 , 1978,122 pp. LA - ENG CD - D8REP AB - CBAC COPYRIGHT: CHEM ABS A discussion of the link between exposure to vinyl chloride (I) and the occurrence of toxic, nonmalignant illnesses involving skin, bones, liver, lungs, and blood is provided. (75-01-4 Vinyl chloride) The regulatory history of I is outlined. The potential for human contact with I is great. About 2.5 billion kg of I are produced each year in the United States. I is produced at 15 plants employing 900 workers. I is also poiymd. at 39 plants, employing more than 5,500 workers. The Environmental Protection Agency has estd. that approx. 5 million people live near enough to I facilities to be within range of detectable airborne concns. of the gas. The prodn., uses, and dispersion of I are discussed, evidence of its toxic and carcinogenic effects are summarised, and strategies for its control are suggested. The appendices contain a list of I-related compds., an approach to evaluation and control of I exposure, and sources for addnl. information. RH - 75-01-4 EM - 8003 144 SI - CA/091/205212W AU - Schaffner F AD - Mt. Sinai Sch. Med., New York TI - Effect of long-term vinyl chloride exposure in mouse liver structure SO - Falk Symp.; VOL 25, ISS Primary Liver Tumors, 1978,189-99 LA - ENG CD - FASYD AB - CBAC COPYRIGHT: CHEM ABS Electron microscopic studies of livers of mice exposed to vinyl chloride monomer for .ltoreq.6 mo revealed changes mainly in and around sinusoids and in sinusoidal lining cells, particularly with only mild alterations of hepatocytes. (75-01-4 Vinyl chloride) The angiosarcomas which developed in some mice arose from the sinusoidal lining cells. Screening for early stages of vinyl chloride-induced hepatic injury must be directed to changes in the microcirculation rather than to changes in hepatocellular function. RN - 75-01-4 DTG - CHRONIC TOXIC DOSE EM - 8001 RNW 1651 00009989 VCM PAGE 59 145 SI AU AD TI SO LA CD AB RN EM CA/091/.30672F Signor ini G ; Saia B 5 Simonato L 5 Saladino G 1st. MtJ Lavoro, Univ. Padova, Padua Clinical data on vinyl chloride-induced angiopathy Riv. Med. Lav. Ig. Ind.5 VOL 2, ISS July-Sept., 1978,261-70 ITA RMLID CBAC COPYRIGHT: CHEM ABS Of 1223 workmen exposed to vinyl chloride and examd. by photcplethysmorgraphy 145 (av age 41.4-.7.5 yr, av. exposure 107.4-.68 mo) showed changes in their tracings (75-01-4 Vinyl chloride) They were sepd. into 3 groups by the severity of the changes. Reaction to the cold-test confirmed The photoplethysmog. method for mass detection of the peripheral vascular changes in workers. 75-01-4 7912 146 SI - CA/091/152569J AU - Egan H * Editor TI - IARC (International Agency for Research on Cancer] Scientific Publications, No. 22: Environmental Carcinogens. Selected Methods of Analysis, Vol. 2: Methods for the Measurement of Vinyl Chloride in Poly(Vinyl Chloride), Air, Water, and Foodstuffs SO - 1978,142 pp. LA - ENG CD - BOOKA AB - CBAC COPYRIGHT: CHEM ABS A book. Book vinyl chloride detn Air vinyl chloride detn book Water vinyl chloride detn book Food vinyl chloride detn book RN - 75-01-4*, 7732-18-5? 9002-86-2 EM - 7912 147 SI AU TI SO LA CD AB RN CA/091/128058W Anon Reagent hazards AR; VOL 16, ISS 10, 1978,458-63 JPN ARRRD CBAC COPYRIGHT: CHEM ABS A review with 3 refs. Review reagent health hazard Safety reagent review 50-00-0; 55-63-0; 56-23-5? 56-38-2; 56-81-5J 60-29-7; 62-53-35 64-17-5J 64-18-65 64-19-7; 64-69-75 67-56-15 67-63-0; 67-64-15 67-66-3', 71-36-35 71-43-25 71-55-65 74-83-95 74-87-35 74-90-85 74_96_4; 75-00-3; 75-01-45 75-04-75 75-07-05 75-09-25 75-15-05 75- 19-45 75-21-85 75-34-35 75-44-55 75-52-55 75-69-45 75-71-85 76- 03-95 77-78-15 78-59-15 78-88-65 78-93-35 79-01-65 79-04-95 79-11-85 79-20-95 79-24-35 79-46-95 87-86-55 88-89-15 94-36-05 95-50-15 98-59-95 98-95-35 99-61-65 100-41-45 100-42-55 106-93-45 106-99-05 107-87-95 108-93-05 109-87-55 107-02-85 108-10-15 108-94-15 109-89-75 107-06-25 108-85-05 108-95-25 109-94-45 107-07-35 108-87-25 109-60-45 110-49-65 107-13-15 108-88-35 109-66-05 110-54-35 107-31-3 108-90-7 109-86-4 110-80-5 RNW 1652 00009990 VCM PAGE 60 EM 198 SI AU AD TI SO LA CD AB RN EM 199 SI AU AD TI SO LA CD AB RN EM 110-82-7; 123-51-35 127-18-9; 997-19-85 7910 110-83-8J 123-86-9J 131-91-9? 506-68-3J 111-15-9; 123-91-1; 191-78-65 62190-13- 111-65-9; 129-38-9; 191-79-7; 111-76-2; 126-99-8; 192-82-5; 121-69-75 127-09-3J 199-62-7; CA/091/118086Q Kappus H ; Koester U ; Koester-Albrecht D ; Kieczka H ; Remmer H Med. Inst. Lufthyg. Si 1ikoseforsch.* Univ. Duesseldorf, Duesseldorf Lipid peroxidation induced by ethanol and halogenated hydrocarbons in vivo as measured by ethane exhalation Funct. Glutathione Liver Kidney, tPap. Konf. Ges. Biol. Chem.] > 25th; 1978,176-82 ENG 90SNA CBAC COPYRIGHT: CHEM ABS Exposure of rats to CC19, EtOH, trichloroethylene, vinyl chloride, CBrCl3* and halothane induced lipid peroxidn. (56-23-5 Carbon tetrachlorideM69-17-5 Ethanol)(79-01-6 Trichloroethylene )(75-01-9 Vinyl chloride )(75-63-8 Bromotrifluoromethane )(151-67-7 Halothane) The expiration of ethane due to CC19 and CBrCl3 exposure were dose-dependent. The higher the 0 concn. in atm., the lower the concns. of ethane produced. The results are discussed in ration to the hepatotoxicity of halogenated hydrocarbons and of EtOH. 56-23-55 69-17-55 79-01-6; 75-01-95 75-63-8J 151-67-7 7910 CA/091/118013P Warren HS 5 Huff JE ; Gerstner HB Toxicol. Inf. Response Cent., Oak Ridge Vinyl chloride: a review, 1835-1975; an annotated literature collection, 1976-1975; a literature compilation, 1976-1977 Report; ISS ORNL/TIRC-78/3,, 1978,218 pp. ENG D3REP CBAC COPYRIGHT: CHEM ABS A report on vinyl chloride consisting of 3 parts: part I is a review of vinyl chloride and its healtn-rr'.ated aspects as summarized from the literature through 1975, Or.- t II comprises an annotated, keyworded, indexed collect. of 555 refs. (1835-1975) which emphasizes biol. effects .-J includes refs, concerning anal, and control in both the <ciace and environment; part III is an updated collection of revs, which extends the bibliog. through Sept. 1977. (75-01-9 Vinyi -rlcride) This bibliog. was compiled from the major scientific abstr. literature. Current journals in appropriate disciplines were also scanned. Refs, are arranged alphabetically by first author's name. A permuted title index is appended for easy access to the bibliog. 75-01-9 7910 RNW 1653 00009991 VCM PAGE 61 150 SI AU TI SO LA CD AB RN EM CA/091/043873H Drugov YS > Murav'eva GV ; Letunovskaya GA Determination of vinyl chloride in the air of industrial buildings Pr-vo Shin> Rezinotekhn. i Asbestotekhn. Izdelii. Nauch.-tekhn. Ref. Sb.! ISS 9, 1978,25-7 RUS D4J0U CBAC COPYRIGHT: CHEM ABS Title only translated. Vinyl chloride detn air 75-01-4 7908 151 SI AU AD TI SO LA CO AB RN EM CA/091/043743R Hobbs JS Appl. Chem. Syst. Ltd., Luton/Bedfordshire Determination of vinyl chloride and other chlorinated hydrocarbons in air Int. Environ. Saf.5 ISS March-April, 1978,22 ENG IESAD CBAC COPYRIGHT: CHEM ABS Air pollutants were detd. directly by flame ionization detector and microwave plasma detector and the methods could det. sub-ppm. levels by compd. concn. by gas chromatog. using Carbowax 1500 on Carbopack A. For example, vinyl chloride, ethyl chloride, and tetrachloroethylene were detd. at .ltoreq.2, .ltoreq.l, and .apprx.l ppm, resp. (75-01-4 Vinyl chloride )(75-00-3 Ethyl chloride)(127-18-4 Tetrachloroethylene) 75-01-4J 75-00-3; 127-18-4 7908 152 SI - CA/091/043726N AU - Hernberg S AD - Tyoterveyslaitos, Helsinki TI - Epidemiological aspects on occupational cancer SO - Duodecim; VOL 94, ISS 14-15, 1978,897-904 LA - FIN CD - DUODA AB - CBAC COPYRIGHT: CHEM ABS A review, with 39 refs., discussing the occurrence of carcinogens in working environments and epidemioi. data relating to As, Ni> Cr, Cd, asbestos, benzene, polycyclic arom. hydrocarbons, arom. amines, vinyl chloride, mineral oil aerosols, sawdust, and ionizing radiation. (71-43-2 Benzene)(75-01-4 Vinyl chloride) RN - 71-43-2; 75-01-4*, 7440-02-0J 7440-38-2; 7440-43-9; 7440-47-3 EM - 7908 RNW 1654 00009992 VCM PAGE 62 153 SI - CA/091/026626N AU - Ishikaua T ; Ose Y 5 Sato T 5 Tomlta B AD - Gifu Coll. Pharm., Gifu TI - Waste water treatment of night soil. IX. Formation of organohalides in the chlorination process of night soil treatment plant SO - Eisei Kagaku; VOL 24, ISS 5, 1978,235-40 LA - JPN CD - ESKGA AB - CBAC COPYRIGHT? CHEM ABS The effluent of a night soil treatment plant was chlorinated with 500 ppm Ca(C10)2 at pH 8.0 and the main prcuuct of the chlorination was CHC13. (67-66-3 Chloroform) The quantity of CHC13 formed was influenced by the amt. of Ca(ClOi2 and by the reaction time. Humic, fulvic, and hymatomelanic acids and MeOH-water-sol. substance were fractionated from the effluent of the night soil treatment plant by the use of Amberlite XAD-2. Each of these 4 fractions was chlorinated at pH 7.0 and all fractions produced chiefly CHC13. In addn., C2H3C13 and C5H9C1 were formed by chlorination of humic acid, and CH2C12, CC14, C2H4C12, C2H3C13, C3H2C12, and PhCl were formed by chlorination of watei--MeOH sol. substance. (75-01-4 Chloroethene )(75-09-2 Dichloromethane)(56-23-5 Carbon tetrachloride H1300-21-6 Dichloroethane )(25323-89-1 Trichloroethane)(108-90-7 Chlorobenzene ) RN - 67-66-3; 75-01-4; 75-09-2; 56-23-5; 1300-21-6; 25323-89-15 108-90-75 7778-54-3 EM - 7908 154 SI - CA/091/026462F AU - Maleev A ; Konstantinova N 5 Stanoev M ; Danev S 5 Deredzhyan S AU - Vasileva Z ; Shipkov T AD - Inst. Intern. Dis. Ther., Sofia TI - Study of liver damage in poly(vinyl chloride) production workers SO - Probl. Vutr. Med.; VOL 6, ISS 2-3, 1978,92-7 LA - BUL CD - PBVMA AB - CBAC COPYRIGHT? CHEM ABS Examn. of 72 workers from a PVC prodn. plant showed no clear relationship between liver damage and work seniority at the plant (even in the case of workers with a seniority >10 yr); although increased bromosulfophthalein retention (up to 3.2X), reduced thrombocyte counts (220,000) and enlargement of the liver were found in several workers, no actual pathol. occurrences were found, and the anomalies could also be related to excessive consumption of ale. drinks. (9002-86-2 PVC) RN - 9002-86-25 75-01-4 EM - 7908 RNW 1655 00009993 VCM PAGE 63 155 SI - CA/091/026434Y AU - Manns H AD - Landesanst. Immissionsschutz Landes Nordrhein-Westfalen* Essen TI - An emission measurement for determination of vinyl chloride SO - Org. Verunreinig. Umwelt: Erkennen, Bewerten, Vermindern, CTag.3 5 1978,511-13 LA - GER CD - 40KFA AB - CBAC COPYRIGHT: CHEM ABS Methods for detg. vinyl chloride in air, particularly adsorption on Mol. sieve 5A, desorption on He, and gas chromatog., are discussed. (75-01-4 vinyl chloride) RN - 75-01-4 EM - 7908 156 SI - CA/091/014626Z AU - Ross RH 5 Yeatts LB Jr ; Lewis EB Dailey GA j Harnden DS AU - Michelson DC > Frogge LM AD - Oak Ridge Natl. Lab., Oak Ridge TI - Environmental and health aspects of selected organohalide compounds: an information overview SO - Report; ISS ORNL/EIS-105,, 1978,512 pp. LA - ENG CD - D3REP AB - CBAC COPYRIGHT: CHEM ABS A review with 915 refs, on the environmental and health effects of difluorodichloromethane, trichlorofluoromethane, CHC13, Me chloroform, CC14, perchloroethvlene, hexachlorobutadiene vinyl chloride, allyl chloride and ethylene dibromide. (75-71-8 Difluorodichloromethane)(75-69-4 Trichlorofluoromethane H67-66-3 Chloroform )(71-55-6 Methyl chloroformH56-23-5 Carbon tetrachloride )(127-18-4 Perchloroethylene M87-68-3 Hexachlorobutadiene)(75-01-4 Vinyl chloride)(107-05-1 Allyl chlorideH106-93-4 Ethylene dibromide) RN - 75-71-85 75-69-4J 67-66-3; 71-55-6; 56-23-5; 127-18-4; 87-68-3; 75-01-4; 107-05-1; 106-93-4 EM - 7908 157 SI - CA/091/009017X AU - Lamorte MF TI - National Emission Standards for Hazardous Air Pollutants. Inspection Manual for Vinyl Chloride SO - 1978,123 pp. LA - ENG CD - BOOKA AB - CBAC COPYRIGHT: CHEM ABS A book. Book vinyl chloride emission std RN - 75-01-4 EM - 7907 RNW 1656 00009994 VCM PAGE 64 158 SI AU AD TI SO LA CD AB RN EM 159 SI AU AD TI SO LA CD AB RN EM 160 SI AU AD TI SO LA CD AB CA/090/209315J Carcassoni B ; Basei R ; Zilio-Grandi F Stabilimento Petrolchim. Montedison S.p.A.> Porto Marghera, Italy Automatic gas chromatograph in the environmental control of the petrochemical industry Inquinamento; VOL 20, ISS 12, 1978,55-62 ITA IQAAA CBAC COPYRIGHT: CHEM ABS The adaptation of std. gas chromatographs to continuous monitoring of air in or around a petrochemicals plant is described. Sep. detectors are used for S02, H2S, total S, NO + H02, total hydrocarbons, dust, and total org. compds. Visual and audible alarms are sounded when preset values for e.g. vinyl chloride monomer, are exceeded and the results are recorded centrally. (75-01-4 Vinyl chloride) 75-01-4J 7440-44-0; 7446-09-5; 7704-34-9*, 7783-06-4; 11104-93-1 7907 CA/090/209267V Krajewski J ; Dobecki M Inst. Med. Pr., Lodz, Pol. Determination of vinyl chloride in the air by gas chromatography Med. Pr.*, VOL 29, ISS 5, 1978,403-10 POL ME PAA CBAC COPYRIGHT: CHEM ABS CH2=CHC1 (I) is estd. in air by gas chromatog. on columns contg. Chromosorb WAW, (Me)2SiCl2, and 10X of silicone SE-30, with the aid of a flame ionization detector. (75-01-4 Vinyl chloride) Prior sorption of I on charcoal makes it possible to det. I concns. down to 1 mg/m3 air. 75-01-4 7907 CA/090/192038W Bai1in LJ Palo Alto Res. Lab., Lockheed Missiles and Space Co., Inc., Palo Alto, Calif. Microwave plasma detoxification process for hazardous wastes. Phase II. Systems application evaluation Report; ISS EPA/600/2-78/080*, Order No. PB-284652,, 1978,33 pp. ENG D8REP CBAC COPYRIGHT: CHEM ABS This preliminary report has revealed new information on several highly toxic substances which exist within the continental US for which there is no satisfactory means of disposal. They exist in multiple ton quantities, as well as small eg batches at a multitude of locations. They are, specifically, materials in search of a disposal method, such as the microwave plasma detoxification process (MWP). These materials which have been surveyed for suitability in the MWP include the following exceedingly dangerous compds. and mixts.: cancel--causing nitrosamines, vinyl chloride and vinylidene RNW 1657 00009995 VCM PAGE 65 chloride* dioxin-contg. organohalogens, and arom. amine compds. which heretofore have been considered only as oddities or as being present only in small quantities; acute-toxicity organometallic compds. and heavy metal complexes such as Hg> As* Ce> and Fb compds.* derived from industrial processes and pesticides; nervepoisons from military sources* which include organophosphorus chemicals stock-piled above ground; and pesticide wastes which are only slightly less hazardous. (75-01-4 Vinyl chloride )(75-35-4 vinylidene chloride )(828-00-2 Dioxin) RN - 75-01-4? 75-35-4*, 828-00-2; 7439-92-1; 7439-97-6 5 7440-38-2 5 7440-43-95 7723-14-0 EM - 7906 161 SI AU AD TI SO LA CD AB RN EM CA/090/19I749S Sudo Y i Yagasaki A 5 Yamazaki H 5 Hagiwara T > Ohshima E Tokyo Natl. Tech. Coll.* Tokyo* Japan The rate of catalytic reaction of vinyl chloride monomer Tokyo Kogyo Koto Semmon Gakko Kenkyu Hokokusho? VOL 10** 1978*71-4 JPN TKSHD CBAC COPYRIGHT: CHEM ABS Vinyl chloride in air was adsorbed on activated C* and the spent C was regenerated by heating. (75-01-4 Vinyl chloride) The heating requires a large amt. of energy, and suitable catalysts were investigated. The catalysts were Cu0-CuCr204, Ni, Si02-A1203, Pt-Al203, and Pd-Al203. The Cu0-CuCr204 (Cu catalyst) was the best. Pt and Pd catalysts deteriorated rapidly because of HC1* a decompn. product of vinyl chloride. The reaction temp, and contact time were 275-368.degree, and 0.2-1.4 s> resp. 75-01-45 1344-28-1*, 7440-02-05 7440-05-35 7440-06-45 7440-47-35 7440-50-85 7631-86-9 7906 162 SI AU AD TI SO AB RN EM CA/090/173936W Frohreich RA 5 Scamehorn JF USA Incomplete drying of activated carbon in a process for vinyl chloride monomer reduction in vapors U.S. PATENT NO. 4128405 12/05/78 (Continental Oil Co.) CBAC COPYRIGHT: CHEM ABS Adsorption of vinyl chloride (I) from PVC reactor effluent vapors on incompletely dried activated C under essentially adiabatic conditions with the heat of adsorption of I desorbing water instead of heating the C bed* results in adsorbing greater amts, of I/lb C less drying needed after regeneration* and less likelihood of undesirable high temp, reactions occurring. (75-01-4 Vinyl chloride )(9002-86-2 PVC) 75-01-45 9002-86-25 7440-44-0 7906 RNW 1658 00009996 VCM PAGE 66 163 SI - CA/090/180981K AU - Ssulinski S AD - Zakl. Hig. Komunalnej Panstw. Zakl. Hig., Warsaw, Pol. TI - Use of a rapid method for evaluating the function of the central nervous system in small laboratory animals in hygienic-toxicological studies SO - Rocs. Panstw. Zakl. Hig.; VOL 29, ISS 6, 1978,677-81 LA - POL CD - RPZHA AB - CBAC COPYRIGHT: CHEM ABS An exptl. set-up is described for toxicol. simultaneous testing of several groups of lab. animals in stimuli discrimination and learning. The technique enables several-day testing without requiring the presence of an experimenter by using electronic devices. The method was applied to the detn. of the effects of Kosulfonate 40, lindane, trichlorfon, and vinyl chloride on the function of the central nervous system in rats. (69989-50-0 Kosulfonate 40H58-89-9 Lindane )(52-68-6 trichlorfon)(75-01-4 Vinyl chloride) RN - 69989-50-05 58-89-9; 52-68-6; 75-01-4 EM - 7906 164 SI - CA/090/156388B AU - Ssybinski Z 5 Popiela T AD - Akad. Med., Krakow, Pol. TI - Early detection of effects of chronic intoxication with vinyl chloride and mercury vapors SO - Med. Pr.; VOL 29, ISS 5, 1978,371-7 LA - POL CD - MEPAA AB - CBAC COPYRIGHT: CHEM ABS Medical examns. and lab. tests are proposed for detecting early effects of chronic intoxications with vinyl chloride (I) and Hg vapors. (75-01-4 Vinyl chloride) Results of the examns. of 168 and 236 persons occupationally exposed to I and Hg, resp., are presented. RN - 75-01-45 7439-97-6 EM - 7905 165 SI - CA/090/156304W AU - Johansson J ; Marthinsson BG ; Eng ST AD - Dep. Electr. Meas. Chalmers Univ. Technol., Goetebrog, Sued. TI - Computer automation and error analysis of a carbon dioxide-laser long-path absorption system for air pollution monitoring SO - IEEE Trans. Instrum. Meas.; VOL IM-27, ISS 4, 1978,358-63 LA - ENG CD - IEIMA AB - CBAC COPYRIGHT: CHEM ABS A C02-laser long-path absorption system is computer automated; lasers and electronic circuits are computer controlled. Estn. of systematic error and imprecision is used to select an optimum measurement strategy for each different pollution situation. In an area of a petrochem. plant, using path lengths of 500-2800 m, C2H4 30-400 and vinyl chloride <50 ppb we^e detected. (74-85-1 Ethylene)(75-01-4 Vinyl RNW 1659 1 # 0 m m m 00009997 VCM PAGE 67 chloride) The systematic errors are 5-10 and the imprecision is 5-25/J. RN - 74-85-15 75-01-4 EM - 7905 166 SI - CA/089/151877E AU - Murakami H ; Okamoto T AD - Japan TI - Continuous purification of a waste gas containing gaseous i mpurities SO - Ger. Offen. PATENT NO. 2651906 05/18/78 (Taiyo Kaken K. K. ) AB - CBAC COPYRIGHT: CHEM ABS Waste gases are scrubbed in a continuous process using a tower operating on the fluidized-bed principle and contg. perforated plates and circulating, spherical activated C for stabilization of the fluidized bed and of the transport of the activated C particles. The plates are arranged in a vertical cascade manner so that 80-95^ of the total plate surface is in 1 zone and 5-207. of the surface in another zone. Thus, vinyl chloride (I) was removed from a waste gas contg. 4947 ppm I in a tower contg. 6 plates with circulating (120 kg/h) activated C spheres of 0.8 min av. diam. (75-01-4 Vinyl chloride) The exit gas contained 5 ppm I. RN - 75-01-4; 7440-44-0 EM - 7811 167 SI - CA/089/151752K AU - Chiorboli C ; Bignozzi CA ; Maldotti A ; Carassiti V AD - 1st. Chim., Univ. Ferrara, Ferrara, Italy TI - Synergistic effects in the photooxidation of ethylene and vinyl chloride induced by 1-3 butadiene 50 - J. Photochem.; VOL 9, ISS 2-3, 1978,113-15 LA - ENG CD - JPCMA AB - CBAC COPYRIGHT: CHEM ABS An increase in 1,3-butadiene (I) concn. in C2H4-I-N02 and vinyl chloride (ID-I-N02 systems accelerated first and then slowed down C2H4 and II photooxidn. processes because of the occurrence of pos. and neg. synergistic effects depending on the relative concns. of the hydrocarbons. (106-99-0 1,3-Butadiene)(74-85-1 Ethylene )(75-01-4 Vinyl chloride) RN - 106-99-0*, 74-85-1; 75-01-4; 10102-44-0 EM - 7811 168 51 - CA/089/124343W AU - Crockett PW AD - USA TI - Toxicity of Vinyl Chloride. (A Bibliography with Abstracts) SO - 1978,86 pp. CD - BOOKA AB - CBAC COPYRIGHT: CHEM ABS A book Book vinyl chloride toxicity RN - 75-01-4 EM - 7810 RNW 1660 00009998 VCM PA6E 68 169 SI AU AD TI SO LA CD AB RN EM 170 SI AU AD TI SO LA CD AB RN EM 171 SI AU AD TI SO LA CD AB RN EM CA/089/117127A Skoglund FO ; Landner L Inst. Vatten- Luftvardsforsk. , Stockholm, Sued. Chlorinated by-products from vinyl chloride manufacture (dichloroethane tars) Inst. Vatten- Luftvardsforsk., tPubl.J B; ISS B 402,, 1978,27 pp. SUE IVLBD CBAC COPYRIGHT: CHEM ABS The enrichment factors for different components of the dichloroethane tar complex, as detd. in accumulation expts. with marine organisms, are 15-300. The lowest concn. of the tar causing subacute effects on marine organisms was 0.5-2 mg/L. The main components of the tar, C1CH2CH2C1 (I) and C12CHCH2C1, contribute to the obsd. toxic effects to a very small extent. (107-06-2 1,2-Dichloroethane )(79-00-5 1,12-Trichloroethane) I gives a clearly pos. reaction in the Ames test, i.e. it is genetically active. 107-06-2: 79-00-5; 75-01-4 7810 CA/089/116893K Sordelli D ; Carcassoni B > Bernardini A ; Genova F Montedison S.p.A., Milan, Italy System for monitoring airborne vinyl chloride in the workroom environment Chim. Ind. (Milan); VOL 60, ISS 2, 1978,97-103 ITA CINMA CBAC COPYRIGHT: CHEM ABS A system of automatic gas anal, by a gas chrcvmatog. is described. Alarms are sounded when the pollution approaches dangerous levels. 75-01-4 7810 CA/089/135030T Bjerke W Norsk Hydro, Rafnes, Norway Petrochemical industry. Purification technology and discharges at Rafnes (Norway) Kjemi; VOL 38, ISS 1, 1978,37-9 NOR KJEMA CBAC COPYRIGHT: CHEM ABS Treatment of wastewater from the prodn. of vinyl chloride and C2H4 is described. (75-01-4 Vinyl chloride)(74-85-1 Ethylene) Limits for the discharge of these petrochem. effluents are reported. 75-01-4; 74-85-1 7810 RNW 1661 00009999 VCM PAGE 69 172 SI - CA/089/134933C AU - Miyauchi T ; Ono M ; Kakuta A AD - Japan TI - Removal of pollutant gases from air SO - Japan. Kokai PATENT NO. 78 42181 04/17/78 (Tokyo Shibaura Electric Co. Ltd.) AB - CBAC COPYRIGHT: CHEM ABS Air contg. pollutant gases such as C2H3C1, C2H3CN, S02, H2S, CS2, NO, N20, and N02 is passed through silicone oil. (75-01-4 Chloroethylene ) RN - 75-01-4 EM - 7810 173 SI AU AD TI SO LA CD AB RN EM CA/089/134834W Carassiti V ; Chiorboli C ; Bignozzi CA ; Ferri A > Maldotti A Cent. Studio, CNR, Ferrara, Italy Atmospheric photooxidation of vinyl chloride: a generalized treatment of the relative rates of product formation Ann. Chim. (Rome); VOL 67, ISS 7-8, 1978,499-512 ENG ANCRA CBAC COPYRIGHT: CHEM ABS The spectral actinic irradiance values at latitude 45.degree.N, valid for the av. Po valley, are estd. as a function of time of the day, season, and of the wavelengths involved in photochem. smog systems. The reactivity of vinyl chloride (I) in these systems and the mechanism of atm. photooxidn. are discussed. (75-01-4 Vinyl chloride) The relative importance of the hydrocarbons emitted in industrial atm. in producing photochem. smog is dependent on the disappearance rate and on the product formation rate. Times for 50V. disappearance of I are estd. and its reaction rate and product formation rate are compared with those of C2H4, in terms of ratio of product concn. vs. time plots. (74-85-1 Ethylene) These generalized plots of the av. relative formation rates are utilized as forecast diagrams of first approxn. 75-01-4; 74-85-1; 10102-43-9 7810 174 SI AU AD TI SO LA CD AB RN DTG CA/089/101251A Muratov MM Gus'kova SI Usb. Nauchno-Issled. Inst. Sanit. Gig. Profzabol., Tashkent, USSR Mutagenic activity of vinyl chloride Gig. Sanit.; ISS 7, 1978,111-12 RUS GISAA CBAC COPYRIGHT: CHEM ABS Continuous exposure of rats to vinyl chloride at 0.15, 0.4, or 10 mg/m3 for 3.5 mo increased the incidence of chromosomal fragmentation, agglutination, and bridging. (75-01-4 Vinyl chloride) The no. of chromosomal aberrations was somewhat greater at 35.degree, than at 22.degree.. Vinyl chloride was nonmutagenic at 0.07 mg/m3. 75-01-4 CHRONIC TOXIC DOSE P I RNW 1662 00010000 VCM PAGE 70 EM - 7810 175 SI AU AD TI SO LA CD AB RN DTG EM CA/089/101001U Bolt HM Inst. Toxicol.* Univ. Tuebingen, Tuebingen, Ger. Pharmacokinetics of vinyl chloride Gen. Pharmacol.; VOL 9, ISS 2, 1978,91-5 ENG GEPHD CBAC COPYRIGHT: CHEM ABS A review with 25 refs, on the pharmacokinetics of vinyl chloride in rats. (75-01-4 Vinyl chloride) 75-01-4 URINE CONCENTRATION 7810 176 SI AU AD TI SO LA CD AB RN EM CA/089/064180D Chmielarska H ; Zielenski K Osr. Badaw.-Rozwojowy Kaucz. Tworzyw Winylowych, Oswiecim, Pol. Study of vinyl chloride adsorption on activated carbon Przem. Chem.5 VOL 57, ISS 4, 1978,193-5 POL PRCHA CBAC COPYRIGHT: CHEM ABS Vinyl chloride adsorption on Polish active C N was investigated. (75-01-4 Vinyl chloride) The adsorption isotherm was measured and the kinetics of the process were detd. The C is a good adsorbent for vinyl chloride and is regenerated well bv steam. 75-01-45 7440-44-0 7809 177 SI AU AD TI SO LA CD AB RN EM CA/089/094336B Wagoner JK ; Hyg SD Off. Assistant Seer., OSHA, Washington, D. C. Vinyl chloride and pulmonary cancer J. Environ. Pathol. Toxicol.; VOL 1, ISS 3, 1978,361-2 ENG JEPTD CBAC COPYRIGHT: CHEM ABS A polemic. The conclusion of G. Reznik et al (ibid. 1977, 1, 105-111) that a case of adenocarcinoma of the bronchus in an org. chemist could not be attributed to exposure to vinyl chloride but was due to exposure to bis(chloron>ethyl ether) is not supported by published data. (75-01-4 Vinyl chloride) 75-01-4 7809 RNW 1663 00010001 VCM PAGE 71 178 SI - CA/089/099295N AU - Ball GW ; Parker RB ; Stevens K AD - S.W.B. Electron. Ltd., Hayes/Middlesex, Engl. TI - The mass spectrometer as a continuous monitor for pollutants and toxic hazards 50 - Adv. Mass Spectrom.; VOL 7B,, 1978,1687-90 LA - ENG CD - AMSPA AB - CBAC COPYRIGHT: CHEM ABS Air pollution by vinyl chloride in the prodn. of PVC was monitored by a transportable mass spectrometer (EMI monitor). (75-01-9 Vinyl chloride)(9002-86-2 PVC) RN - 75-01-95 9002-86-2 EM - 7809 179 51 - CA/089/085389U AU - Timar M Haber J ; Mandi A ; Galgoczy G AD - Baranya Megyei Tud. Kozl., Orsz. Munka- Uzemegeszsegugyi Intez., Budapest, Hung. TI - The identification of vinyl chloride in various substances 50 - Munkavedelem; VOL 29, ISS 1-3, 1978,39-95 LA - HUN CD - MUNKA AB - CBAC COPYRIGHT: CHEM ABS Vinyl chloride was detd. in air, blood, and water by gas chromatog. using N as a carrier gas. (75-01-9 Vinyl chloride) From air, vinyl chloride was adsorbed on activated C and desorbed either by, rapid thermal desorption, or by using CS2 as a solvent. A Vendarex Q column was used in case of solvent desorption and a chromosorb 102 column in case of thermal desorption. The rapid thermal desorption was carried out at 350.degree.. In blood, vinyl chloride was detd. following diln. with water, addn. of octyl ale. and N sweeping. The detn. threshold was 0.06 ppm in rat blood. No addn. of octyl ale. was required for detn. in water. The threshold was 20 ppb. RN - 75-01-95 7732-18-5 EM - 7809 180 51 - CA/088/109735M AU - Mayer A ; Comera J 5 Charpentier H ; Jaussaud C AD - Univ. Bremen, Bremen, Ger. TI - Absorption coefficients of various pollutant gases at carbon dioxide laser wavelengths; application to the remote sensing of those pollutants SO - Appl. Opt.; VOL 17, ISS 3, 1978,391-3 LA - ENG CD - APOPA AB - CBAC COPYRIGHT: CHEM ABS A 2-wavelength C02 laser designed for atm. pollution measurements was used for detg. the absorption coeffs. of 13 gas pollutants at C02 laser lines between 9.2 mum and 10.8 .mu.m. All measurements were done with the pollutant at a low pressure in the presence of 1 atm of air. Sensitivities of .apprx.5 ppb for a 1-km path were obtained for ethylene. (79-85-1 Ethylene) RNW 1664 00010002 VCM PAGE 72 RN - 74-85-1 71-43-2; 74-93-1; 75-00-3; 75-01-4; 75-69-4; 75-71-85 79-01-6; 106-99-0? 107-06-25 126-99-85 127-18-4; 7446-09-5; 7664-41-7 EM - 7804 181 SI AU AD TI SO LA CD AB RN EM CA/094/115656B Mueller G ; Norpoth K Inst. Staublungenforsch., Univ. Muenster, Muenster Studies on the biotransformation of indirectly active carcinogenic industrial substances in mammals Moeglichkeiten Grenzen Biol. Monit./Arbeitsmed. Probl. Dienstleltungsgewerbes/Arbeitsmed. Kolloq., B; 1978,83-8 GER 44JJA CBAC COPYRIGHT: CHEM ABS ADDENDUM The mutagenic effect of acetamide, benzene, chloroform, 1,1-dimethylhydrazine, and hexamethylphosphorie acid triamide (I) on Escherichia coli and Salmonella typhimurium was independent of dose. (60-35-5 AcetamideH71-43-2 Benzene)(67-66-3 Chloroform)(57-14-7 1,1-Dimethylhydrazine)(680-31-9 hexamethylphosphoric acid triamide) I underwent oxidative demethylation in rats which released formaldehyde. (50-00-0 Formaldehyde) Dichlorodiethyl ether (II) showed a dose-dependent mutagenicity in Enterobacteriaceae oxygenase test. (27753-54-4 Dichlorodiethyl ether) II was metabolized to chloracetaldehvde which was coupled with glutathione and over S-carboxymethylcysteine degraded to thiodiglycolic acid. (107-20-0 Chloracetaldehyde)(70-18-8 Glutathione )(638-23-3 S-Carboxymethyleysteine)(123-93-3 Thiodiglycolic acid) This metabolic pathway elucidates the carcinogenic effect of II. Thiodiglycolic acid also was found in the urine of rats treated with chloroethanol. (107-07-3 Chloroethanol) Inhalation of vinyl chloride by rats resulted in urinary excretion of a reactive electrophilic metabolite. (75-01-4 Vinyl chloride) 60-35-55 71-43-2; 67-66-3; 57-14-75 680-31-95 50-00-0; 27753-54-4; 107-20-05 70-18-85 638-23-35 123-93-3; 107-07-35 75-01-4 8110 182 SI - CA/090/001203P AU - Juhnke I J Luedemann D AD - Krefeld* Gar. TI - Results of the study of 200 chemical compounds on acute fish toxicity using the Golden Orfe test SO - Z. Wasser Abwasser Forsch.; VOL 11, ISS 5, 1978,161-4 LA - GER CD - ZUABA AB - CBAC COPYRIGHT: CHEM ABS ADDENDUM Lethal concn. values for 200 chems. as detd. by the golden orfe test of H. Mann (1976) in 2 different labs, are given. RN - 50-00-0; 50-29-3; 56-23-55 56-38-25 56-81-5; 57-13-6; 58-89-95 60-29-75 60-35-55 62-53-35 63-25-25 64-17-5; 64-19-75 65-85-0; 67-56-15 67-63-05 67-64-1; 67-66-35 71-43-25 75-01-45 75-04-7; RNW 1665 00010003 VCM PAGE 73 75-05-S; 5-07-0} 75-09-2} 75-15-0} 75-85-9} 75-86-5} 76-03-9 77-92-9, ;6-82-o; 78-83-1} 78-92-2} 78-93-3} 79-01-6} 79-10-7 80-15-V .1-62-6} 89-66-2} 87-68-3} 88-72-2} 88-85-7} 88-89-1 90-02-t. 3-76-5} 95-99-8} 95-50-1} 95-53-9} 95-68-1} 95-92-1 95-93-c s >76-33-3; 96-91-3} 98-00-0} 98-01-1} 98-06-6} 98-07-7 98-82-85 98-95-3} 99-65-0} 100-01-6 } 100-91- 9} 100-92 -5} 100-99-7} 100-97-0} 100-52-7} 100-66-3} 101-81-5} 101-89-8 102-71-6} 109-75-6} 105-37-3} 106-68-3} 106-89-8} 107-02-8 107-05-1} 107-11-9} 107-13-1} 107-15-3} 107-19-7} 107-21-1 107-92-6} 108-05-9} 108-10-1} 108-21-9} 108-29-7} 108-39-9 108-88-3} 108-90-7} 108-91-8} 108-99-1} 108-95-2} 109-57-9 109-60-9} 109-86-9} 109-99-9} 110-12-3} 110-19-0} 110-59-3 110-63-9} 110-82-7} 110-83-8} 110-86-1} 111-27-3} 111-92-2 111-96-6} 111-70-6} 111-87-5} 112-27-6} 112-30-1} 112-39-5 120-83-2} 120-92-3} 122-79-2} 123-01-3} 123-31-9} 123-92-2 123-59-6} 123-72-8} 123-86-9} 123-91-1} 126-73-8} 131-17-9 135-01-3} 138-86-3} 139-13-9} 191-32-2} 191-93-5} 191-78-6 191-97-9} 192-82-5} 192-96-1} 193-33-9} 199-99-0} 199-62-7 150-76-5} 151-21-3} 291-69-5} 301-09-2} 302-17-0} 539-22-5 590-88-5} 591-35-5} 592-59-6} 559-12-1} 583-60-8} 592-76-7 622-95-7} 623-37-0} 626-93-7} 628-63-7} 628-81-9} 628-92-2 1310-73-2*, 1313-82-2; 1330-20-7; 1333-73-9; 1796-81-2; 1912-29-9} 7379-28-9} 7997-90-7} 7631-99-9} 7632-05-5} 7696-85-7} 7697-01-0} 7697-15-6} 7681-99-9} 7681-82-5} 7718-59-9} 7758-98-7} 7761-88-8} 7778-93-0} 7778-79-7} 7803-57-8} 10102-18-8} 10325-99-7} 10361-37-2} 10588-01-9} 13398-93-1} 13597-99-9} 13796-98-0} 19959-60-0} 17619-22-6} 25323-89-1} 26952-21-6} 30899-19-5} 35296-72-1} 51312-29-9} 62309-51-7} 68563-01-9} 68563-02-0} 110-91-8 EM - 8007 183 SI AU AD TI SO LA CD AB RN EM CA/088/165026T Kurlyandskii BA } Tomilina LA } Dukhovnaya AI } Stovbur NN Gorodskaya Sanepidstants. Moscow* USSR Pathogenesis of cardiovascular dysfunction during chronic poisoning with vinyl chloride Gig. Sanit.} ISS 2, 1978,109-5 RUS GISAA CBAC COPYRIGHT: CHEM ABS ADDENDUM Vinyl chloride inhaled by rats at 300 mg/m3 for 9.5 h daily initially activated the sympathetic and then the parasympathetic nervous system. (75-01-9 vinyl chloride) After 7 mo inhalation at 20 mg/m3 vinyl chloride stimulated the parasympathetic nervous system. Adrenaline loading initially increased and then decreased the sensitivity of adrenoreceptors to vinyl chloride. Chronic exposure to vinyl chloride disrupted the neuroautonomic and cardiovascular functions, with initial compensatory changes in the neurohormonal balance and subsequent disruption of the autonomic regulation with a dominant parasympathetic influence. 75-01-9 8007 RNW 1666 I 00010004 VCM PAGE 74 184 SI AU AD TI SO LA CD AB RN EM CA/090/126557P Kotlvar IB 5 Seregina AI USSR Protection of the environment from vinyl chloride contamination in poly(vinyl chloride) production Plast. Massy; ISS 10, 1978,58-61 RUS PLMSA CBAC COPYRIGHT: CHEM ABS A review with 99 refs. Review vinyl chloride environment protection PVC manuf environment protection review 75-01-45 9002-86-2 7904 185 SI AU AD TI SO LA CD AB RN EM CA/090/109108A Leichnitz K Ger. Some information on a long-term measuring system for gases and vapors Draegerheft; VOL 312,, 1978,27-34 GER DRAEA CBAC COPYRIGHT: CHEM ABS The use of Draeger tubes in the long-term detn of NH3, C6H6, HCN, Cl, chloroprene, CO, C02, hydrocarbons, HC1, S02, H2S, N02, NOx, PhMe, C2HC13, and vinyl chloride in air is described. (71-43-2 Benzene)(126-99-8 Chloroprene)(108-88-3 Toluene)(79-01-6 Trichloroethylene )(75-01-4 Vinyl chloride) 71-43-2; 126-99-85 108-88-3; 79-01-6; 75-01-4; 74-90-8; 124-38-9; 630-08-0? 7446-09-55 7647-01-0; 7664-41-7; 7782-50-5; 7783-06-45 10102-44-CJ 11104-93-1 7904 186 SI - CA/090/109085R AU - Kohl EG Pruggmeyer D % AD - Battelle-Inst. e. V., Frankfurt/Main, Ger. TI - Air pollution caused by vinyl chloride from PVC factories SO - Ber. - Umweltbundesamt (Ger.); ISS 5, 1978,23 pp. LA - GER CD - BEUMD AB - CBAC COPYRIGHT: CHEM ABS The vinyl chloride (I) content of German PVC samples (emulsion, suspension, bulk) was substantially <10 ppm, except for 3 samples from the same firm, in which I concns. were 44, 81, and 82 ppm. (75-01-4 Vinyl chloride 5(9002-86-2 PVC) In foreign PVC, I concns. were generally <10 ppm, but 20/ of the samples contained substantially >100 ppm I. In 67 finished products, I concns. were <0.1 ppm for 50 and <5 ppm for 5, with the exception of insulating panels, of which 9 contained 20-50 ppm I and 3 contained 109-973 ppm I. The concn. and emission of I for a given sample of PVC during various stages of processing are discussed, and a simple method for e monitoring the I content, particularly at >10 ppm in PVC raw m RNW 1667 i # 00010005 VCM PAGE 75 materials, is described. RN 75-01-45 9002-86-2 EM - 7904 SI _ CA/090/098506A AU - Kahn MS AD - Rutgers, State Univ., New Brunswick N. J. m TI - The mechanism of ethylene and vinyl chloride as initiators in banana ripening SO _ Diss. Abstr. Int. B 1979, 39(7), 3223-4J 1978,100 pp. LA - ENG CD - DABBB AB - CBAC COPYRIGHT: CHEM ABS A disser. Banana maturation ethylene vinyl chloride RN _ 74-85-15 75-01-4 EM - 7904 188 SI CA/090/098263U AU Ibrahim FB m AO Rutgers, State Univ., Hew Brunswick, N. J. TI Effect of vinyl chloride on metabolites of germinated seeds SO Diss. Abstr. Int. B 1979, 39(7), 32825 1978,101 pp. LA ENG m CD DABBB AB CBAC COPYRIGHT: CHEM ABS A disser. Vinyl chloride seed germination metabolite PN 75-01-4 m EM 7904 189 SI - CA/090/076013K AU - Sudduth JR ; Keyworth DA m AD - USA TI - Purification of gas streams SO - U.S. PATENT NO. 4104146 08/01/78 (Tenneco Chemicals, Inc.) AB - CBAC COPYRIGHT: CHEM ABS The gas stream, contg. 10-1000 ppm m vinyl chloride (I) from heating of a polymn. slurry, is passed at specific rates through a silent elec, discharge zone in an 03-generating app. to destroy .gtoreq.952 of the I content and result in a stream contg. .ltoreq.10 ppm I. (75-01-4 Vinyl chloride) Thus, when an air stream (contg. 282 ppm I) was passed at 0.33 L/min through a silent elec, discharge zone in an ozonator, 99.32 of the I content was destroyed 1 min after emergence from the ozonator (the I content was further reduced by reaction with 03 formed in the ozonator). RN - 75-01-45 9002-86-25 10028-15-6 EM - 7903 RNW 1668 I 00010006 VCM PAGE 76 190 SI - CA/090/075908U AU - Miller B Kane PO ; Robinson DB ; Whittingham PJ AD - Mond Div.,ICI Ltd., Runcorn, Engl. TI - Determination of a 24-hour time-weighted average value of environmental vinyl chloride monomer concentration by charcoal adsorption followed by gas chromatography SO - Analyst (London); VOL 103, ISS 1232, 1978,1165-72 LA - ENG CD - ANALA AB - CBAC COPYRIGHT: CHEM ABS The concn. of CH2:CHCl in the atm. was detd. by drawing atm. through a tube packed with activated charcoal for 24 h, extg. the adsorbed CH2:CHC1 into CS2, and detg. the extd. CH2:CHCl by gas chrcmatog. (75-01-4 Vinyl chloride) The detection limit is 0.005 vol. ppm and the precision is .+-.10X relative under lab conditions. Interference by other atm. pollutants, e.g. Cl or CH2CC12, is negligible. The technique was tested at 2 flow rates and at 2 industrial sites. The agreement between the expts. at different flow rates is .+-.10X relative. RN - 75-01-4 EM - 7903 191 SI - CA/090/075897Q AU - Pochon M AD - Lonza A.-G. Visp, Suits. TI - Measurement of vinyl chloride (VCM) in the atmosphere with portable and stationary systems SO - Chimia; VOL 32, ISS 12, 1978,488-96 LA - GER CD - CHIMA AB - CBAC COPYRIGHT: CHEMABS The detn. of vinyl chloride in air by color test tubes, gas sampling tubes with gas chromatog., sample bags, portable detectors with solid-state sensors, halide detectors, flammable gas detectors, personal sampling pumps, IR spectrometers, monitors with test papers tapes, flame-ionization monitors, and process gas chromatographs is discussed. (75-01-4 Vinyl chloride) RN - 75-01-4 EM - 7903 192 SI - CA/090/075888N AU - Santoleri JJ AD - Trane Therm. Co., Conshohocken, Pa. TI - Thermal oxidation: a solution to the VCM emissions problem SO - Book Proc. Annu. Ind. Air Pollut,/Contam. Control Semin.; VOL 8,, 1978,Paper No. 11, 9 pp. LA - ENG CD - BPASD AB - CBAC COPYRIGHT: CHEM ABS Vinyl chloride monomer and other hydrocarbons in air or waste gas were combusted in a vortex burner to remove the pollutants. (75-01-4 Vinyl chloride) By-product heat and HC1 were recovered. The thermal oxidn. RNW 1669 00010007 VCM PAGE 77 method can handle air contg. 4-21.7X vinyl chloride. RN - 75-01-45 7647-01-0 EM - 7903 193 SI - CA/090/060498M AU - Asendorf E Albrecht P ; Hoepfner B AO - Ger. TI - Method and apparatus for determining halogen-carbon and halogen-hydrogen compounds* especially vinyl chloride SO - Ger. Offen. PATENT NO. 2716963 10/19/78 AB - CBAC COPYRIGHT: CHEM ABS The content of halogen-C compds. In waste gases is detd. continuously by catalytic thermal hydrolysis in the presence of H20 at 550-650.degree, with the formation of XH (X = halogen), absorption of XH in deionised H20, and measuring the elec. cond. of the H20. A Pt or Pt-alloy wire is used as the heating element and catalyst. The content of vinyl chloride is detd. from the difference of the readings for 2 gas streams converted at 580 and 450.degree., resp. (75-01-4 vinyl chloride) Vinyl chloride and all other X-C compds. are thermally hydrolysed at 580.degree., whereas only the accompanying X-C compds. (not vinyl chloride) are thermally hydrolysed at 450.degree.. An alarm signal is actuated when the difference between these 2 readings exceeds a preset value. RN - 75-01-4 EM - 7903 194 SI AU AD TI SO LA CD AB RN EM CA/090/060450Q Khan ZS ; Hughes TW Monsanto Res. Corp., Dayton, Ohio Source assessment: polyvinyl chloride Report; ISS EPA/600/2-78/0041, MRC-DA-7005 Order No. PB-283395,, 1978,107 pp. ENG D8REP CBAC COPYRIGHT: CHEM ABS This report summarises data on air emissions from the PVC industry. (9002-86-2 PVC) PVC is manufd. by 20 companies at 35 plants. Each plant uses .gtoreq.l of 4 possible polymn. processes: (1) suspension polymn.: (2) emulsion polymn.: (3) bulk polymn.: and (4) soln. polymn. A representative PVC plant was defined to assess the severity of emissions from this industry. Source severity, defined as the ratio of the time-averaged max. ground level concn. of a pollutant to a hazard potential, was calcd. for 16 chem. species emitted from a representative plant. The 2 largest severities were 970 for vinyl chloride and 1.9 for PVC. (75-01-4 Vinyl chloride) Control technol. for hydrocarbons includes adsorption, absorption, refrigeration, incineration, stripping, purging of equipment with inert gas or water, and control of fugitive emissions. 9002-86-2; 75-01-4 7903 RNW 1670 00010008 VCM PAGE 78 195 SI AU AD TI SO LA CD AB RN EM CA/090/060352J McMurry JR 5 Tarr J Texas Air Control Board, Tex. Vinyl chloride in Texas' ambient air Proc. Annu. Tech. Meet. - Inst. Environ. Sci.5 VOL 24, ISS Comb. Environ. Technol. Interrelat.* 1978,149-53 ENG IESPA CBAC COPYRIGHT: CHEM ABS Gas chromatog. is used -for measurement of ambient air concns. of vinyl chloride (I) at lower abs. detectable 1 imits of 0.2 nL and a relative extd. deviation of 20X. (75-01-4 Vinyl chloride) Existing ambient air concns. of I in Texas (.ltoreq.13 ppb/vol.) do represent a possible hazard. 75-01-4 7903 196 SI AU AD TI SO LA CD AB RN EM CA/090/081858U Simmon VF Stanford Res. Inst. Menlo Park* Calif. Structural correlations of carcinogenic and mutagenic alkyl halides DHEW Publ. (FDA) (U. S.)5 ISS FDA 78-1046, Struct. Correl. Carcinog. Mutagen.,, 1978,163-71 ENG DHEFD CBAC COPYRIGHT: CHEM ABS Eight of 10 carcinogenic alkyl halides were mutagenic in Salmonella typhimurium TA100; the exceptions were CHC13 and CC14. (67-66-3 Chloroform)(56-23-5 Carbon tetrachloride) Thirteen alkyl halides of unknown carcinogenic activity were mutagenic in these assays. Of particular interest was the mutagenic activity of CH2C12, which is produced in excess of 100,000 tons annually and which has a broad environmental exposure. (75-09-2 Methylene chloride) The mutagenic activity of the alkyl halides correlated well with their known chem. reactivity. 67-66-3) 56-23-55 75-09-2; 74-83-9; 74-87-3; 74-88-4; 74-95-3; 74-97-5; 75-01-4J 75-25-2; 75-27-4; 75-35-4; 79-01-6; 87-68-3; 106-89-8J 107-05-1*, 107-94-8J 111-44-4; 124-48-1; 141-76-4; 590-21-6 5 590-92-1*, 39638-32-9 7903 197 SI - CA/090/049100E AD - Natl. Inst. Occup. Saf. Health, Rockville, Md. TI - Current Intelligence Bulletin 28: vinyl halides carcinogenicity. Vinyl bromide, vinyl chloride, and vinylidene chloride SO - DHEW (NIOSH) Publ. (U. S.)5 ISS 79-102,, 1978,11 pp. LA - ENG CD - DNPUD AB - CBAC COPYRIGHT: CHEM ABS A review with 35 refs, on the carcinogenicity of vinyl bromide, vinyl chloride, and vinylidene chloride. (593-60-2 Vinyl bromide )(75-01-4 Vinyl chloride)(75-35-4 Vinylidene chloride) RNW 1671 00010009 VCM PAGE 79 RN - 593-60-25 75-01-4; 75-35-4 EM - 7903 198 SI AU AO TI SO LA CD AB RN EM CA/090/043368B Berg S ' Frostling H ; Jacobsson S Dep. Anal. Chem., Univ. Stockholm* Stockholm, Swed. Chemical analysis of fire gases with gas chromatography-mass spectrometry Int. Symp. Control Air Poilut. Work. Environ., CProc.l; VOL Part 1,, 1976i309-21 ENG 39PRA CBAC COPYRIGHT^ CHEM ABS Hazardous gases from fires were analyzed 'ey gas chromatog.-mass spectroscopy. The gases were sampled in glass tubes, eluted with He, coned, in a cooling trap, sepd. in a glass column on Tenax GC. Alkanes, alkenes, lower monchyd. "i c ales., AcH, furan, and C6H6 derivs. occur in fires in dwelling house. (75-07-0 Acetaldehyde)(110-00-9 Furan)(71-43-2 Benzene; N compds. occur in fires from polyurethane foams. 75-07-0; 110-00-95 71-43-2; 64-17-5; 67-56-1', 67-64-1; 74-85-1; 74-86-2; 74-87-3J 74-90-85 74-99-7; 75-01-4; 75-05-85 75-52-55 78-93-35 91-20-35 92-52-45 95-13-6; 98-01-15 98-88-45 100-42-55 100-47-0 *, 100-52-75 106-97-85 106-98-9', 106-99-0; 107-12-0 5 107- 13-15 107-31-3; 107-87-95 108-08-75 108-88-35 108-90-7; 108- 95-25 109-02-4; 109-66-05 109-67-15 110-54-35 110-86-1; 111-65-95 111-66-05 115-07-1; 120-92-35 126-98-75 142-29-05 142-82-55 271-89-65 542-92-7; 592-41-65 620-02-05 689-97-4; 1319-73-9*, 1321-94-45 4170-30-35 12002-48-15 25321-22-65 25495-88-9; 25550-22-55 25586-38-3; 26760-64-55 27137-41-35 28802-49-55 37275-41-55 38719-68-5; 50985-84-75 68923-44-4 7902 199 SI - CA/090/043308G AU - Anderson HA ; Snyder J ; Lewinson T ; Woo C 5 Lilis R AU - Selikoff IJ AD - Mt. SinaiSch. Med., City Univ. New York, New York, N. Y. TI - Levels ofCEA among vinyl chloride andpoly(vinyl chloride )-exposed workers SO - Cancer (Philadelphia); VOL 42, ISS 3, Suppl., 1978,1560-7 LA - ENG CD - CANCA AB - CBAC COPYRIGHT: CHEM ABS In 1974, vinyl chloride (VC) exposed workers had an increased risk of malignant disease (hemangiosarcoma of the liver). (75-01-4 Vinyl chloride) Thus 1147 workers exposed to VC monomer in 3 VC/poly(vinyl chloride) (PVC) . plants and 269 workers from a PVC extrusion plant manufg. PVC textile product, exposed to much lower concns. of VC were examd. (9002-86-2 Poly(vinyl chloride)) Included among the comprehensive clin. and lab. studies conducted was the CEA (carcinoembryonic antigen) titer. The investigation demonstrated that occupational exposures in VC/PVC plants can cause elevations in the CEA titers of otherwise healthy individuals. Prospective follow-up is necessary before conclusions can be drawn concerning RNW 1672 00010010 VCM PAGE 80 the usefulness of the CEA titer as a predictive indicator of possible increased risk. RN - 75-01-4J 9002-86-2 EM - 7902 200 SI AU AD TI SO LA CD AB RN DTG EM CA/090/017285C Bingham E USA Research methods employed in the evaluation of volatile agents on biological systems Int. Symp. Control Air Pollut. Work. Environ.i CProc.] ; VOL Part It, 1978,29-41 ENG 39PRA CBAC COPYRIGHT! CHEM ABS In rats exposed chronically (60 wk ) to EtOH (5X) and vinyl chloride (600 ppm) liver tumors occurred earlier and more frequently than in rats exposed to just EtOH or vinyl chloride. (64-17-5 Ethanol)(75-01-4 Vinyl chloride) The setting of safe exposure limits for industry in the face of the synergism of environmental agents with individual toxic agents is discussed. 64-17-5; 75-01-4 CHRONIC TOXIC DOSE 7902 201 SI AU AD TI SO LA CD AB CA/090/034611Y Winell M ; Holmberg B ; Kronevi T Unit Occup, Toxicol., Natl. Board Occup. Saf. Health, Sued. A possible correlation between biochemical changes and pathological findings in VCM-exposed mice and hamsters Int. Svmp. Control Air Pollut. Work. Environ., tProc.]; VOL Part 1,, 1978,152-66 ENG 39PRA CBAC COPYRIGHT: CHEM ABS Mice and hamsters were exposed by inhalation to 50 and/or 500 ppm vinyl chloride monomer (VCM) during 6-18 mo. (75-01-4 Vinyl chloride) Blood samples were taken at regular intervals during the exposure for anal, of plasma enzymes indicative of liver damage or early malignancy. Some animals were sacrificed for histopathol. examns. after 6 mo and the rest were examd. when deed or moribund. Aik. phosphatase and total lactate dehydrogenase (LDH) activities were elevated in VCM exposed mice. There was also a shift towards cathodic isoenzyme;: of LDH. The transaminases were not significantly elevated. No changes in plasma enzymes were found in exposed hamsters. Pathol, examn. of VCM-exposed mice showed the presence of hemargicsarcomas in fat tissue, histol. benign alveologenic lung adenoids as well as a few benign and malignant tumors at various sites. Only 1 liver hemangiosarcoma was noted. No liver fibrosis ..as seen. All mice exposed to 50 ppm VCM for 76 mo developed Tumors. Tumor incidence was high also in the hamsters. Enzyme changes occurred late in the study, subsequent to tumor appearance. The value of enzyme changes as a diagnostic RNW 1673 000100X1 VCM PAGE 81 criterion on tissue injury or early malignancy caused by VCM was discussed. RN - 75-01-4 DTG - CHRONIC TOXIC DOSE EM - 7902 202 SI - CA/090/028367G AU - Anon AD - Engl. TI - Remov'al of vinyl chloride monomer from gases 50 - Res. Disci.*, VOL 175,, 1978,5 LA - ENG CD - RSDSB AB - CBAC COPYRIGHT! CHEM ABS Vinyl chloride vapors were selectively removed from waste gases from PVC prodn. by treating the gas with ether acetates, diacetates, or triacetates. (75-01-4 Vinyl chloride)(9002-86-2 PVC) RN - 75-01-4; 9002-86-2J 64-19-7 EM - 7902 203 51 - CA/090/011688Q AU - Eisenstein AJ ; Frohreich RA ; Scamehorn JF AD - USA TI - Adiabatic VCM adsorption on carbon 50 - U.S. PATENT NO. 4098593 07/04/78 (Continental Oil Co.) AB - CBAC COPYRIGHT: CHEM ABS The removal by dry C bed-adsorption of vinyl chloride (I) monomer nVCM) from waste gases in which the initial concn. of I is >12,000 ppm by vol. is improved by dilg. the waste gas with an inert gas to give a I concn. of 4000-12,000 ppm by vol. and adsorbing the I under essentially adiabatic conditions at .apprx.120 psig and initial bed temps, of 60-200.degree. F. (75-01-4 Vinyl chloride) The inert gas is selected from the group C02, N, air, and waste gas from which I has been removed. RN - 75-01-4*, 7440-44-0 EM - 7901 204 51 - CA/089/220194U AU - Sittig M AD - USA TI - Vinyl Chloride and PVC Manufacture: Process and Environmental Aspects SO - 1978,354 pp. CD - BOOKA AB - CBAC COPYRIGHT: CHEM ABS A bock. Book vinyl chloride PVC environment Polyvinyl chloride manuf environment book RN - 75-01-45 9002-86-2 EM - 7901 RNW 1674 00010012 VCM PAGE 82 205 SI - CA/089/220018Q AU - Nestaas I Lundberg NH AD - Norway TI - First part of theBamble study! background pollutant levels SO - Kjemi; VOL 38, ISS 5,1978,25-6, 29 LA - NOR CD - KJEMA AB - CBAC COPYRIGHT: CHEM ABS Prior to the establishment of new petroleum plants, the background levels of 03, PAN, NOx, hydrocarbons, S02, S042-, acidity in dust, vinyl chloride, and dust fallout were detd. (2278-22-0 PANM75-01-4 Vinyl chloride) RN - 2278-22-0*, 75-01-4; 7446-09-55 10028-15-65 11104-93-1 EM - 7901 206 SI AU AD TI SO AB RN EM CA/0S9/203393R Yang K ! Reedv JD 5 Lindberg RC USA Nitrite-impregnated carbon for the adsorption recovery of vinyl chloride monomer U.S. PATENT NO. 4081512 03/28/78 (Continental Oil Co.) CBAC COPYRIGHT: CHEM ABS The impregnation of active C with an inorg. nitrite greatly reduces the formation of C2H2 and C02 in the adsorptive recovery of H2C:CHCl from gas streams. (74-86-2 Acetylene)(75-01-4 Vinyl chloride) For example, when a N feed conta. 10/ H2C:CHCl and 1/ 0 was passed through a C bed which had been prspd. by soaking 100 g C in 200 g water contg. 2 g NaN02 and drying, the formation of C2H2 and C02 as 100.degree, was 0.0 and O.Omu mol/min, resp. compared with 0.0 and 1.7 for C treated with 2V. hydroquinone and 0.12 and 0.8 for untreated C. 74-86-25 75-01-45 124-38-9; 7440-44-05 7632-00-0 7901 207 SI AU AD TI SO LA CD AB RN EM CA/089/203257Z Neu NP Comput. Cent., Solvay et Cie S. A., Brussels, Belg. Minicomputer connected to process-chromatographs for monitoring air pollutants in working areas Textes Conf. Cadre Congr. Int. "Contrib. Calc. Electron. Dev. Genie Chim. Chim. Ind.'S VOL D, 1978,44-9 ENG 39EYA CBAC COPYRIGHT: CHEM ABS Air pollution by vinyl chloride during the prodn. of PVC was monitored by a gas chromatograph equipped with a minicomputer. (75-01-4 Vinyl chloride )(9002-66-2 PVC) 75-01-45 9002-86-2 7901 RNW 1675 T 00010013 VCM PAGE 83 208 SI - CA/089/203112Y AU - Hoffmann D 5 Schmeltz I > Hecht SS ; Brunnemann KD ; Wynder EL AO - Naylor Dana Inst. Dis. Prev., Am. Health Found., Valhalla, N. Y. TI - Volatile carcinogens occurrence, formation and analysis SO - Prev. Detect. Cancer, tProc. Int. Symp.], 3rd; VOL 1, ISS 2, 1978,1943-59 LA - ENG CD - 37ATA AB - CBAC COPYRIGHTS CHEM ABS A review with 33 refs, covering vinyl chloride, chlorinated hydrocarbons, bisichloromethyl lether, N-nitrosamines, and hydrazines. (75-01-4 Vinyl chloride H542-88-1 Bis(chloromethyl lether) RN - 75-01-4*, 542-88-1; 302-01-2 EM - 7901 209 SI AU AD TI SO LA CD AB RN EM CA/089/185395M Howland RG > Mailace CJ Jet Propul. Lab., Pasadena, Calif. Chlorine and activated carbon treatment for removal of toxic substances from water Water Chlorination: Environ. Impact Health Eff. Proc. Conf.; VOL 2,, 1978,659-74 ENG 37KXA CBAC COPYRIGHT: CHEM ABS For water systems requiring chlorination for disinfection, the inherent danger of such practice is greatly reduced when a C .fwdarw. Cl .fwdarw. C treatment is employed. Chlorination enhanced the removal of PhOH and aliph. amines, over that accomplished by C alone. (108-95-2 Phenol) For both the volatile halogenated orgs. and the hexene-extd. orgs., the effect of chlorinating at 50 ppm Cl caused no increased hazard over that incurred with 10 ppm Cl. The final C treatment reduced the hazard of releasing toxic Cl compds. into the environment. 108-95-2*, 67-66-3*, 74-89-5; 75-01-4*. 75-25-2; 75-27-4*, 107-10-8*, 7440-44-0 7812 210 SI - CA/089/185129C AD - Fr. TI - Risks due to vinyl chloride monomer in poly(vinyl chloride) processing SO - Cah. Notes Doc.; VOL 90,, 1978,167-72 LA - FRE CD - CNDIB AB - CBAC COPYRIGHT: CHEM ABS The release of vinyl chloride monomer vapor into the atm. from PVC during various handling and processing operations can be hazardous to health. (75-01-4 Vinyl chloride)(9002-86-2 PVC) The Tech. Commltee for French Wood Industries has specified a max. permissible concn. of 2 ppm by vol. for these emissions. A survey of the conditions under which the vapor is released, a detailed anal, of a wide range of RNW 1676 I * I I 00010014 VCM PAGE 84 # 0 0 -- processing situations* and the appropriate ventilation methods to be adopted are given. RN 75-01-4J 9002-86-2 EM 7812 211 SI AU CA/089/185014M Greene MW ; Riccio SG 5 Dencker WD > Wilson RI AD Adv. Technol. Oper., Beckman Instrum., Inc. Anaheim* Calif. TI Chemiluminescent monitor for vinyl chloride SO U. S. NTIS, PB Rep.5 ISS PB-277391,, 1978,51 pp. LA ENG CD XPBRC AB CBAC COPYRIGHT: CHEM ABS A monitor for vinyl chloride monomer (VCM) in ambient air was constructed using com. available components of a gas chromatog. (GC) coupled with a chemiluminescence 03 analyser slightly modified to make it suitable for use as a GC detector. (75-01-4 Vinyl chloride) The specificity for VCM is enhanced by use of a chemiluminescence detector because satd. hydrocarbons do not chemiluminesce with 03. A custom absorption trap capable of concg. the VCM from 1 L (or more) of ambient air was used to extend the lower detection limit. Using a custom trap-heating circuit* the coned, sample can be thermally eluted into the GC in a gas vol. of 10 mL or less* providing a 100-fold increase in sensitivity compared to that obtained with a 10 mL sample loop. Preliminary system and final acceptance test results are reported in detail and indicate that a monitor of this type can detect <1 ppb of VCM in ambient air operating on a 15-min cycle, If the concn. trap is replaced by a 20 mL sample loop, the limit of detection is estd. to be about 35 ppb VCM when ooeratinq or i a 5-min cycle. RN - 75-01-4 EM -- 7812 212 SI - CA/089/184865C AU - Boyd RV Jr AD - Eng. Dep. Ethyl Corp. TI -- Computer assisted moni air SO - Anal. Instrum.; VOL 16 LA - ENG CD - AINSB AB -- CBAC COPYRIGHT: CHEM , basically consists of 1 alarms plus a minicomputer for data processing. Monitoring system consists of a gas chromatog. multipoint sampling system (including time weighted av. sample accumulators), audible and visual field alarm network that facilitates protection of personnel from exposure to vinyl chloride, and the minicomputer data redn. and presentation formats. (75-01-4 Vinyl chloride) RN 75-01-4 EM 7812 RNW 1677 00010015 VCM PAGE 85 213 SI - CA/089/174626M AU - Maly E AD - Inst. Ind. Hyg. Oecup. Mad., Bratislava, Czech. TI - On thereaction of vinylchloride with DNA 50 - Int. Congr.Ser. - Excerpta Med.; VOL440, ISS Ind. Environ. Xenobiotics, 1978,270-3 LA - ENG CD - EXMDA AB - CBAC COPYRIGHTS CHEM ABS Vinyl chloride reacted to a greater extent with denatured than with native herring sperm DNA in vitro in aq. soln. (75-01-4 Vinyl chloride) However, vinyl chloride failed to react with previously acylated calf thymus DNA in vitro in citrate buffer. RN - 75-01-4 EM - 7812 214 51 - CA/089/174S24J AU - Koester U ; Albrecht D ; Kappus H AD - Inst. Tox'kol., Univ. Tuebingen, Tuebingen, Ger. TI - Lipid pe-tvidation induced by different halogenated aliphatic hydrocar jr.s as measured by malondialdehyde formation in vitro and bv ei'hane evolution in vivo 50 - Int. Congr. Ser. - Excerpta Med.; VOL 440, ISS Ind. Environ. Xenobw I'.s , 1978,235-7 LA - ENG CD - EXMDA AB - CBAC CPYRIGHTs CHEM ABS Ethane exhalation levels (as a monitor of in vivo lipid peroxidn.) of rats treated with 0.1 g CBrCl3/kg 1 g Cvl4/kg, 27. vinyl chloride, 4X halothane, and 2.5X trichlrrcethylene were 18, 37, 8, 14, and 6 nmol/kg, resp. (75-62-7 Bromotrichloromethane)(56-23-5 Carbon tetrau uoride)(75-01-4 vinyl chloride)(151-67-7 halothane )(79-01-6 trichloroethylene ) These results paralleled closely maicnaldehyde formation (as a monitor of in vitro lipid peroxidn.) in in vitro studies. RN - 75-62-7*, 56-23-5*, 75-01-4*, 151-67-7J 79-01-6 EM - 7812 215 51 - CA/089/174464G AU - Bolt HM ; Laib RJ 5 Filser J ; Buchter A *, Bolt N AD - Inst. Toxikol., Univ. Tuebingen, Tuebingen, Ger. TI - Metabolic activation and disposition of vinyl chloride in vivo and in vitro SO - Int. Congr. Ser. - Excerpta Med.; VOL 440, ISS Ind. Environ. Xenobiotics, 1978,261-3 LA - ENG CD - EXMDA AB - CBAC COPYRIGHT: CHEM ABS A review with 21 refs, on vinyl chloride metab. (75-01-4 Vinyl chloride) RN - 75-01-4 EM - 7812 RNW 1678 00010016 VCM PAGE 86 216 SI - CA/089/158411G AU - Kneffei Z ; Desi I ; Farkas I AD - Orss. Kozegeszsegugyi Intez., Budapest, Hung. TI - Study of the toxic effect of vinyl chloride monomer in animal tests SO - Muanyag Gumi; VOL 15, ISS 4, 1978,125-6 LA - HUN CD - MUGUA AB - CBAC COPYRIGHT! CHEM ABS Chronic oral administration of vinyl chloride at 3-1200 mg/kg/day caused toxicity symptoms in rats, such as locomotor disturbances, decrease of the immune titer, electrocardiog. modifications, and loss of hair. (75-01-4 Vinyl chloride) The liver wt. was increased by 600 and 1200 mg vinyl chloride/kg. RN - 75-01-4 EM - 7812 217 SI - CA/089/158314C AU - Kurlyandskii BA ; Stovbur NN ; Dukhovnaya AI AD - Mosk. Gorod. Sanepidstants., Moscow, USSR TI - Probability assessent of the comparative sensitivity of body systems to vinyl chloride poisoning SO - Gig. Sanit.; ISS 8, 1978,51-5 LA - RUS CD - GISAA AB - CBAC COPYRIGHT: CHEM ABS Rats were exposed for 4 h to inhalation of 0.4-4.4 g vinyl chloride/m3. (75-01-4 Vinyl chloride) The neuromuscular system was the most sensitive to the toxic action of vinyl chloride, followed by arterial pressure, hepatic function, and gonads. The reproductive system was affected only by the highest concn. of vinyl chloride. RN - 75-01-4 EM - 7812 218 SI - CA/088/046173D AU - So MS AD - N. Korea TI - Physico-chemical properties of vinyl monomers and their fungiostatic action SO - Choson Minjujuui Inmin Konghwaguk Kwahagwon Tongboj VOL 25, ISS 3, 1977,152-4 LA - KOR CD - CKWTA AB - CBAC COPYRIGHT: CHEM ABS ADDENDUM Antifungal activity was studied for 14 vinyl compds. and was in the order CH2:CHCl < CH2:CHCHO .apprxeq. CH2:CHCN < CH2:CHCH20H < CH2:CHC02H < CH2:CHPh < 4-vinylpyridine (I), Me < Et < Br < Bu in terms of R group in CH2:CHOR, and butadiene < isoprene < chloroprene. The antifungal activity of I was 120-fold greater than that of CH2:CHC1. RN - 75-01-4*, 107-02-85 107-13-1; 107-18-6J 79-10-7} 100-42-55 100-43-65 80-62-6; 97-88-15 818-44-05 75-35-4; 79-41-4; 98-83-9; RNW 1679 276 SI - CA/O96/0114420 CC - CA/161003 AU - Kaufmann RF ; Gleason TA Elluiood RB 5 Lindsey GP TI - Ground-water monitoring techniques for arid zone hazardous waste disposal sites SO - Ground Water Monit. Rev.; VOL 1, ISS 3, 1981,47-54 PT - JOURNAL ARTICLE CY - USA LA - ENG CD - GU'MRD IS - 0277-1926 AB - CBAC COPYRIGHT: CHEM ABS ADDENDUM Groundwater monitoring technol wastewater disposaljPipes and Tubes Steel, in monitoring of groundwater in waste disposal sites of arid zonejSampling apparatus In groundwater monitoring in waste disposal sites of arid zoneJWastewater treatment Evapn. pond, buried electrode system for monitoring of leakage from, in arid zone RN - 112-95-85 124-07-2? 5911-04-6*, 7732-18-5J 9002-86-2*, 9003-56-95 73789-15-8; 80297-58-1; 80297-59-2 EM - 8405 RNW 1680 00010008 PVC PAGE 136 277 SI CC AU TI SO PT CY LA AB RN EM 278 SI CC AU AU TI SO PT CY LA AB RN CA/096/057807E CA/163007 Dudley BJ 5 Williams JL Nonthrombogenic articles U.S. PATENT NO. 4302368 11/24/81 (Becton, Dickinson and Co.) PATENT USA ENG CBAC COPYRIGHT: CHEM ABS ADDENDUM Materials having reduced thrombogenicity and which are useful for purposes requiring their contact with whole blood consist of polymeric resins* and ammonium compds* RR1NH2+ A- (where R = C12-18 alkyl* R1 = Cl-6 alkyl and A = anion of a sol. heparin salt). These materials show excellent blood compatibility without exhibiting the toxicity assocd. with the polymers which are treated with quaternary ammonium compds. and heparin. A tube fabricated from polyethylene 70 and Bi oxychloride 30/ (by wt.) was treated by steeping it in and aq. dispersion of dodecylmethylammonium chloride for 16 h at 65.degree.. The tube was cooled, washed and dried and then immersed in an aq. soln. of Na heparinate (1/ by wt.) for 36 h at 65.degree.. This was then crosslinked with glutaraldehyde for 4 h and washed and dried at 50.degree.. This polymer tube was nontoxic at the desired blood compatibility level. 2292-50-45 2787-53-35 9002-84-0*, 9002-86-2*, 9002-88-4*, 9002-89-55 9003-07-05 9003-39-8; 9003-53-65 9005-49-6*, 32509-42-55 80648-70-05 80648-71-15 80648-72-25 80648-73-3 8405 CA/096/016090X CA/105004 Kochmann W 5 Lafrenz M 5 Lange E 5 Moeller FW 5 Naumann J Pfeiffer HD 5 Thust U 5 Trautner K 5 Higert H 5 Ziegler K Agent for controlling undesirable organisms in waters Ger. (East) PATENT NO. 149302 07/08/81 (VEB Chemiekombinat Bitterfeld) PATENT Ger. Dem. Rep. GER CBAC COPYRIGHT: CHEM ABS ADDENDUM Slow-release aquatic molluscicidal, algicidal, fungicidal, and bactericidal formulations are prepd. by incorporating a known pesticide into PVC C9002-86-23 or PVC copolymer, together with a PVC-sol. compd., such as a plasticizer, and a water-sol. compd., such as an inorg. salt. Thus, a compn. is given, contg. tributyltin oxide [56-35-93 5, PVC 100, di-Bu phthalate 20, and NaCl 20 parts by wt. In water, the compn. showed fast initial release of the active ingredient, followed by slow , prolonged release for .ltoreq.380 days. In an aquarium expt., the compn. controlled the snail Biomphalaria glabrata, with no damage to fish (Lebistes reticulatus) and plants (Elodea and Potamogeton). 56-35-95 70-30-45 122-34-95 137-26-85 147-84-25 3380-34-55 RNW 1681 00010009 PVC PAGE 137 4342-30-75 4342-36-3', 7647-14-5J 9002-86-2J 10043-52-4; 19883-10-4 EM - 8405 279 SI - CA/099/058188C CC - CA/159006 AU - Pusderliski A TI - Stability of lewisite drops on the surfaces of different materials 50 - Naucno-Teh. Pregl.; VOL 31, ISS 9, 1981,45-8 PT - JOURNAL ARTICLE CY - Yugoslavia LA - SCR CD - NPGLA AB - CBAC COPYRIGHT: CHEM ABS Lewisite mixt stability substrate safety;Asphalt Lewisite mixt. drop stability onjBricks Lewisite mixt. drop stability onSConcrete Lewisite mixt. drop stability on;Leather Lewisite mixt. drop stability on CalfskinjRubber Lewisite mixt. drop stability on Butyl;Safety Lewisite drop stability in relation to, substrate effect on;Sand Lewisite mixt. drop stability on;Soils Lewisite mixt. drop stability onjWood Lewisite mixt. drop stability onjWool Lewisite mixt. drop stability on RN - 541-25-3J 7784-34-1; 9002-86-2; 9002-88-45 40334-69-8 EM - 8309 280 51 - CA/099/010081K CC - CA/159002 AU - Hi mi Y AD - Kanagawa Prefect. Environ. Cent., Kanagawaken TI - The emissions of heavy metals into the atmosphere during municipal solid waste incineration SO - Kanagawa-ken Taiki Osen Chosa Kenkyu HokokuJ VOL 23,, 1981,236-40 PT - JOURNAL ARTICLE CY - Japan LA - JPN CD - KTOHD AB - CBAC COPYRIGHT: CHEM ABS Incinerator municipal metal pollution5Air pollution By metals, from municipal incinerator, refuse compn. in relation to?Flue gases Municipal, metals in, refuse compn. in relation to IncineratorJIncinerators For municipal refuse, metal emission from, refuse compn. in relation tojMetals Air pollution by, from municipal incinerators, refuse compn. in relation to Heavy;Uaste solids Incineration of, metal emissions from, refuse compn. in relation to Municipal refuse RN - 7439-92-15 7439-97-65 7440-31-55 7440-43-95 7440-66-65 9002-86-2 EM - 8308 RNW 1682 00010010 PVC PAGE 138 281 SI CC AU AO TI SO PT CY ZP LA CD IS AB RN EM CA/098/214287W CA/117005 Vergnaud JM ; Messadi D ; Taverdet JL U.E.R. Sci. Univ. Saint-Et 1 erne * Saint-Eti enne Plasticizer migration from plasticized PVC into liquids Org. Coat. Plast. Chem.; VOL 45,, 1981,41-5 JOURNAL ARTICLE Fr. 42100 ENG OCPCD 0161-214X CBAC COPYRIGHT: CHEM ABS PVC plasticizer migration food Dioctyl phthalate migration food PVC5Food Plasticizer migration from PVC in models of 117-81-75 9002-86-2 8307 282 SI - CA/098/185546X CC - CA/163008 AU - Andreeva IS ; Zemtsova LV ; Kuksanov NK AD - Inst. Tsitol. Genet., Novosibirsk TI - Radiation sterilization of immobilized enzymes # SO - Immobi1izovannye Proteoliticheskie Fermenfy Lech. Gnoino-Nekroticheskikh Protsessov; 1981,111-18 PT - MONOGRAPH CY - USSR LA - RUS CD - 49KQA AB - CBAC COPYRIGHT: CHEM ABS The optimum dose of gamma-radiation for sterilization of enzymic prepns. Trypsillin (trypsin [9002-07-7] immobilized on CM-cellulose), Profezym (Bacillus subtilis protease [9001-92-7] immobilized on AE-cellulose), enzyme-immobilized polymeric blood vessel catheters, and films with immobilized trypsin was 2.5 Mrad. The redn. of the proteolytic activity of the enzymes by radiation was insignificant and varied within 1.5X. Increasing the dose (4-6 Mrad) inactivates the enzymes substantially, and a dose <2.5 Mrad did not result in complete sterilization. RN - 9001-92-75 9002-07-7; 9002-86-25 9002-88-4; 9004-32-4J 9032-36-4 EM - 8306 283 SI - CA/098/131561E CC - CA/159005 AU - Bergamaschi A 5 Carelli G 5 Magnavita N Vinci F 5 Vincenti A AD - 1st. Med. Lavoro, Univ. Cattol., Rome TI - Saturnism risk in the poly(vinyl chloride) processing industry SO - Ann. 1st. Super. Sanita; VOL 17, ISS 3, 1981,495-500 PT - JOURNAL ARTICLE CY - Italy LA - ITA CD - AISSA RNW 1683 00010011 PVC PAGE 139 IS - 0021-2571 AB - CBAC COPYRIGHT: CHEM ABS PVC processing health hazard leadjAir pollution By lead, in polyvinylchloride manuf., health hazards ofJHealth hazard Of lead exposure in polyvinylchloride processing Occupational RN - 7439-92-1J 9002-86-2 EM - 8305 284 SI - CA/098/024315F CC - CA/171011 AU - Stojanik B ; Lieser KH AD - Fachber. Anorg. Chem. Kernchem., Tech. Hochsch. Darmstadt> Darmstadt TI - Dissolution of plutonium oxide during wet ashing of medium-level wastes SO - Nukl. Entsorgung; VOL 1>> 1981>295-308 PT - JOURNAL ARTICLE CY - Fed. Rep. Ger. ZP - D-6100 LA - GER CD - NUKED AB - CBAC COPYRIGHT: CHEM ABS Dissoln plutonium oxide wet ashing Wet ashing medium level waste Radioactive waste wet ashing Reactor fuel waste wet ashingjNuclear reactor fuel reprocessing Dissoln. of plutonium oxide during wet ashing in relation tojRadioactive wastes Dissoln. of plutonium oxide during wet ashing of Medium-levelJRubber Wet ashing of medium-level wastes contg.> plutonium oxide dissoln. in relation to Neoprene RN - 1344-57-65 7429-90-5; 7439-89-6; 7440-66-6J 7664-93-9; 9002-86-2; 9002-88-4; 12059-95-9 EM - 8302 285 SI - CA/097/187340D CC - CA/159001 AU - Usmani AM AD - Res. Inst.> Univ. Davton> Dayton TI - Plastic> rubber> and PVC processing emissions SO - Org. Coat. Plast. Chem.; VOL 44>> 1981>357-63 PT - JOURNAL ARTICLE CY - USA ZP - 45469 LA - ENG CD - OCPCD IS - 0161-214X AB - CBAC COPYRIGHT: CHEM ABS Chem emission plastic rubber processing Rubber processing chem emission detn Polyvinyl chloride processing emission detn Plastic processing chem emission detnjAir analysis Chem. emission detn. by> in workplace> during processing of plastics and polytvinyl chloride) and rubber, methods for;Plastics Processing of, emissions from, detn. of, methods for;Rubber Processing of, emissions from, detn. of, methods for Synthetic;Waste gases Pollutant detn. in, emission detn. by, in processing of plastics and rubber RNW 1684 A 00010012 PVC PAGE 140 r RN - 9002-86-2 EM - 8212 286 SI CC AU AD TI SO PT CY LA CD AB RN EM CA/097/157675Z CA/104004 Sharom MS Solomon KR Univ. Guelph, Guelph Adsorption and desorption of permethrin and other pesticides on glass and plastic materials used in bioassay procedures Can. Tech. Rep. Fish. Aquat. Sci . 5 VOL 990>, 1981,340-4 JOURNAL ARTICLE Can. ENG CTRSD CBAC COPYRIGHT: CHEM ABS The adsorption and desorption of permethrin (I) [52645-53-11 on glass and several plastic materials that may be used for the construction of limnocorrals were investigated. I was substantially adsorbed on polyethylene [9002-88-41 and polyvinyl chloride [9002-86-21, but not on glass and teflon [9002-84-01. Adsorbed I was not easily desorbed from polyethylene and polyvinyl chloride by several water rinses. Increased adsorption of I was obsd. with increasing temps. A study on the adsorption of several herbicides of various water solys. indicated that trifluralin [1582-09-81 was adsorbed to glass and that there was no general relation between adsorption of the herbicide on polyvinyl chloride and water soly. It is important to det. the role of pesticide adsorption (on bioassay containers) on the overall disappearance of the chem. in aquatic systems or its toxicity to aquatic organisms. 1582-09-8; 9002-84-0; 9002-86-2; 9002-88-45 52645-53-1 8211 287 SI CC AU AD TI SO PT CY LA CD AB RN CA/097/171021Q CA/171010 Steinhaeusler F ; Pohl-Rueling J 5 Pohl E Div. Biophys., Univ. Salzburg, Salzburg Control of radon daughter concentration in mine atmospheres with the use of radon diffusion barriers Radiat. Hazards Min.: Control, Meas., Med. Aspects, Int. Conf.; 1981,127-30 MONOGRAPH Austria ENG 4SDGA CBAC COPYRIGHT: CHEM ABS Radon diffusion barrier mine Polyamide radon barrier Health physics mine Safety radon barrier mine5Diffusion Of radon and its decay products, in mines, polyamide as barrier forJHealth physics In mines, radon diffusion barrier injMines and Mining Radon diffusion barrier in, polyamide for5Polyamides As diffusion barrier, for radon, in minejRocks Radon emanation from, in mine, diffusion barrier for5Rubber As diffusion barrier, for radon, in mine Synthetic 9002-86-2J 9002-88-4J 10043-92-2 RNW 1685 00010013 PVC PAGE 141 EM - 8211 288 SI - CA/097/168356X CC - CA/160005 AU - Haxo HE Jr AD - Matrecon Inc. Oakland TI - Testing of materials for use in the lining of waste disposal faci1ities 50 - ASTM Spec. Tech. Publ.5 VOL 760, ISS Hazard. Solid Waste Test., 1981,269-92 PT - JOURNAL ARTICLE CY - USA ZP - 94623 LA - ENG CD - ASTTA IS - 0066-0558 AB - CBAC COPYRIGHT: CHEM ABS Lining testing waste disposal facility Clay soil liming waste disposal Asphalt concrete lining waste disposal Polymer liming waste disposal;Alkanes Linings, testing of, for waste disposal faci1ities5Asphalt Linings from, testing of, for waste disposal faci1ities{Bentonite Linings from, testing of, for waste disposal facilitiesJBitumens Lining sealants, testing of, for waste disposal faci1ities{Cement Linings from, testing of, for waste disposal facilities{Clays Linings from, testing of, for waste disposal faci1ities;Linings For waste disposal faci1ities{Polyesters Linings from, testing of, for waste disposal faci1ities;Polymers Linings from, testing of, for waste disposal faci1ities;Rubber Linings, testing of, for waste disposal facilities Ethylene-propenejRubber Linings, testing of, for waste disposal facilities Neoprene;Rubber Linings, testing of, for waste disposal facilities Butyl{Soils Linings from, testing of, for waste disposal facilities{Urethane polymers Linings from, testing of, for waste disposal faci1ities{Waste solids Linings for retention of leachate from, testing of, for disposal faci1ities{Wastes Linings for retention of, testing of, for disposal faci1ities{Wastewater Linings for retention of, testing of, for disposal facilities{Water pollution By wastes and leachates from waste solids, lining for waste facilities for control of RN - 9002-86-2*, 9002-88-4*, 9003-29-6 EM - 8211 289 51 - CA/097/09S319M CC - CA/163007 AU - Mizutani Y AD - Fac. Dent., Tokyo Med. Dent. Univ. Tokyo TI - Biocompatibility of medical synthetic polymers utilized in maxillofacial surgery. Evaluation of cytotoxicity to cultured cell and elution tendency of polymer elements SO - Kokubyo Gakkai Zasshi{ VOL 48, ISS 4, 1981,415-38 PT - JOURNAL ARTICLE CY - Japan ZP - 113 00010014 PVC PAGE 142 LA CD IS AB RN EM 290 SI CC AU AD TI SO PT CY LA CD AB RN EM JPN KOGZA 0300-9149 CBAC COPYRIGHT: CHEM ABS The biocompatibility of polymers used for maxillofacial surgery was tested using com. thermosetting elastomers: Realastic (I), polyfvinyl chloride) C9002-86-2J ; Epithane-3 (II) and System HC-107/ON-105 (III), and Silastic MDX4-4210 (IV). From L-cell count change after culturing with the ext. of a cited amt. of elastomers, I and IV were cytostatic at 1-10 mg/mL and 10-100 mg/mL, reso., II was cytostatic at 1 mg/mL and cytocidal at 3.2-10 mg/mL, and IV was noncytotoxic at 10-100 mg/mL. By morphol. observation under a contrast microscope, I and II were cytostatic at 1-3.2 mg/mL and 1 mg/mL, resp., and cytocidal at 10 mg/mL and 3.2-10 mg/mL, resp. III was cytostatic at 10-100 mg/mL, and IV was noncytotoxic at 10-100 mg/mL. DNA, RNA and protein syntheses rates were detd. by radioactivity incorporation rate using 3H-thymidine, 3H-uridine and 3H-Leu. I inhibited DNA and protein, and moderately inhibited RNA synthesis, either II or III inhibited all of these syntheses, and IV moderately inhibited DNA and RNA and accelerated protein synthesis. Elution tendency was evaluated by repeated extns. during 24 h using a medium contg. 10X serum, followed by measurement of the decrease in the DNA synthesis inhibition of the L-cell: I 100X, II 86X, III 36/., and IV lb'/.. 9002-86-2 8210 CA/097/114602F CA/159005 Tharr DG Hazard Evaluations Tech. Assist. Branch, Natl. Inst. Occup. Saf. and Health, Cincinnati Health hazard evaluation report No. HETA-81-403-1024, roofing site, Miami, Florida Report; ISS HETA-81-403-1024; Order No. PB82-182742,, 1981,9 pp. TECHNICAL REPORT USA ENG D8REP CBAC COPYRIGHT: CHEM ABS Occupational health hazard roofer Hydrochloric acid occupational health hazardJAdhesives Air pollution by, occupational exposure to, health hazards of, to roofers;Air pollution By hydrochloric acid, occupational exposured to, health hazard of, to roofersjRoofing Occupational health hazard to roofers insolvents Air pollution by, occupational exposure to, health hazards of, to roofers 7647-01-0; 9002-86-2 8210 RNW 1686 00010015 PVC PAGE 143 291 SI CC AU TI SO PT CY LA CD AB RN EM CA/097/114441C CA/159001 Prokhorova EK ; Boyarskaya VL ; Kalinin VE ; Blinov VN Determination of Cl-4 alcohols in the air of the working rone in the presence of laser radiation on poly(vinyl chloride) materials Povysh. Effekt. Tekhn. Sredstv Okhrany Truda, M.; 1981*122-5 JOURNAL ARTICLE USSR RUS D3RAP CBAC COPYRIGHT: CHEM ABS Ale detn air PVC irradn Laser radiation PVC ale detnjAir analysis Ale. detn. in, in laser radiation action on PVCUlcohols Detn. of, in air of working rone of laser radiation action on PVC Cl-4;Laser radiation PVC irradn. by, ale. detn. in air of working rone of 9002-86-2 8210 292 SI CC AU TI SO PT CY LA CD AB RN EM CA/097/097570Z CA/159004 Alanova TG * Mikheev/a TY 5 Abramova IV Catalytic cleaning of waste gases from polytvinyl chloride) production and tablecloths made of poly(vinyl chloride) Katalit. Ochistka Otkhodyashch. Garov Prom. Predpriyatii i Vykhlop. Garov Avtotransp. Materialy 3-i J ISS Ch. 1, 1981,173-6 JOURNAL ARTICLE USSR RUS D3RAP CBAC COPYRIGHT: CHEM ABS PVC waste gas catalytic treatment Tablecloth PVC emission catalytic treatmentJCatalysts and Catalysis Of waste gas, from PVC manufg. and PVC tablecloths;Vinyon fibers Tablecloths, waste gas from, catalytic treatment ofJWaste gases Catalytic treatment of, from PVC manufg. and PVC tablecloths 9002-86-2 8210 293 SI - CA/097/028552H CC - CA/163007 AU - Tyutyukina LS ; Khokhlova TA ; Mel'nikova GO > Nikitina LS AU - Fedotov BG ; Valiullina VA ; Chernokal'skii BD AD - Ivanov. Nauchno-Issled. Inst. Plenochn. Pokrytii Iskusstven. Koshi. Tekh. Narnachen., Ivanovo . TI - Use of organoarsenic compounds for the disinfection o po yme materials SO - Khim. Tekhnol. Elementoorg. Soedin. Polim., 1981,49 PT - JOURNAL ARTICLE CY - USSR LA - RUS CD AB - CBAC COPYRIGHT: CHEM ABS A no. of organoarsenic compds. were RNW 1687 4i 00010016 PVC PAGE 144 examd. for their antifungal properties in model PVC [9002-86-23 compns. contg. plasticizers> stabilizers, fillers, and pigments. 10,10'-bis(phenoxyarsine) oxide [58-36-63 , 10-chlorophenoxarsine [2865-70-53 , 10-ethylphenoxarsine [5437-44-53 , And 10-fluoro-5,10-dihydrophenarsazine [779-04-43 are fungicidal in their free forms. The 1st 2 compds. assure the fungal resistance of the polymer compn. at 0.02 uit.X, whereas the latter 2 were active at 0.2 wt.X. UV irradn. of these polymeric samples contg. organoarsenic compds. changed the compn. and fungicidal properties insignificantly. In related expts. fungicidal, toxic, and physicomech. properties of Estabex ABF were compared to those of its modified analog. The toxicity of the analog was much lower. Also, UV irradn. does not alter the physicomech. properties of the polymer materials. The Estabex ABF analog may be used in artificial skin prepns. RN - 58-36-6; 779-04-4*, 2865-70-5J 2896-10-8*, 5437-44-5J 9002-86-2*, 26037-41-25 82187-65-3 EM - 8208 294 SI CC AU AU AD TI SO PT CY LA CD IS AB RN EM CA/097/043656P CA/160001 Boulenger P ; Audoin L 5 Lambert S ; Llauro D ; Marechal D Gros D Serv. Technol. Environ., Inst. Rech. Chim. Appl. Use of bacterial beds in water treatment reactor lining. New formulation Eau Ind.; VOL 54,, 1981,39-46 JOURNAL ARTICLE Fr. FRE EINSD 0337-9329 CBAC COPYRIGHT: CHEM ABS Biofiltration plastic lining wastewater treatment Polyvinyl chloride biofilter lining wastewater Polyethylene biofilter lining wastewater treatment Dairy wastewater biofiltration plastic liningSDairy industry Wastewater from, biofiltration, of, plastic linings for;Wastewater treatment Plastic linings for, surface load effects on Biol, filtration. 9002-86-2; 9002-88-4 8208 295 SI CC AU AD TI SO PT CY ZP LA CD CA/096/223226M CA/163008 Ilium L ; Bundgaard H Dep. Pharm. Chem. AD, R. Dan. Sch. Pharm., Copenhagen Sorption of drugs by plastic infusion bags J. Pharm. Pharmacol.? VOL 33, ISS Suppl., 1981,102P JOURNAL ARTICLE Den. DK-2100 ENG JPPMA II RNW 1688 00010017 PVC PAGE 145 IS - 0022-3573 AB - CBAC COPYRIGHT: CHEM ABS Sorption isotherms -for of warfarin Na [129-06-63 , various benzodiazepines, and other drugs and chems. from aq. soln. by PVC C9002-86-2] infusion bags over 7 days at 22.degree, were of the const, partition types. For warfarin Na> the plastic could be satd. by the drug at high soln. concns. For the benzodiazepines there was a relation between the initial rate of absorption and the n-hexane/water partition coeffs. of the drugs. The 'diffusion'> rather than the 'closed 2 compartment kinetic' model gave the better fit for'the kinetics of uptake. The increased loss from soln. of warfarin Na with decreased pH showed that the nonionized form of the drug was the partition species. Sorption of the compds. by infusion bags of polvethylene [9002-88-4] and polypropylene [9003-07-0] was much reduced compared with that by PVC bags. .RN - 129-06-6] 146-22-5J 439-14-5; 604-75-1; 2898-12-6; 9002-86-2; 9002-88-4; 9003-07-05 12794-10-4 EM - 8207 296 SI CC AU AD TI SO PT CY ZP LA CD AB RN EM CA/096/223152J CA/163005 Fessi H ; Carstensen JT ; Puisieux F ; Marty JP Lab. Pharm. Galenique, Fac. Pharm. Paris-Sud, Chatenay Malabry Plastic matrix-type sustained-release formulations: physical study of compression Int. Conf. Pharm. Technol. Prod. Manuf., [Pap.]; 1981>Paper No. 13, 22 pp. MONOGRAPH Fr. 92290 FRE 47SVA CBAC COPYRIGHT: CHEM ABS The effect of compression on polymer, e.g. PVC [9002-86-2], poly(vinyl acetate) [9003-20-7], and vinyl acetate-vinyl chloride copolymer [9003-22-9], matrixes for sustained-release pharmaceuticals was studied with the matrix alone or in the presence of excipients and lubricants. The T. Higuchi relation (1954) concerning applied lubrication, but with an ordinate of origin which might be different from zero, accounts for the rearrangement of particles in the compression chamber. The polymers may deform with rupture of the particles but are not subject to plastic deformation. Treatment of variations in energy as a function of the compression force applied allowed detn. of the force necessary to achieve rearrangement of the particles. 9002-86-2; 9003-20-7*, 9003-22-9 8207 RNW 1689 TT 00010018 PVC PAGE 146 297 SI CC AU AD TI SO PT CY ZP LA CD IS AB RN EM 298 SI CC AU AD TI SO PT CY ZP LA CD IS AB RN CA/096/212499B CA/105004 Sanders CJ Great Lakes Forest Res. Cent, Can. For. Serv., Sault Ste. Marie Release rates and attraction of PVC lures containing synthetic sex attractant of the spruce budworm, Choristoneura fumiferana (Lepidoptera Tortricidae) Can. Entomol. VOL 113, ISS 2, 1981,103-11 JOURNAL ARTICLE Can. P6A 5M7 ENG CAENA 0008-347X CBAC COPYRIGHT: CHEM ABS Release rates of synthetic attractant compn. contg. (E)-ll-tetradecenal [35 746 - 21-53 and (Z )-ll-tetradecenal C35 746 - 21-53 of the spruce budworm, C. fumiferana, from a PVC C9002-86-23 formulation were detd. by wt. loss. They varied in direct proportion to the initial concn, of the attractant avid also with the size of the pellet. Release rates declined by .apprx.50X over 10-40 days and 40-100 days. Initially they were 2 to 3 times lower at 10.degree, than at 21.degree., but were far more const, over time at the lower temp. A 130 nig pellet contg. 42 mug attractant released an estd. 1-1 mug/day, or 40-40 ng/h, which is close to the rate of emission by a calling female, and field trapping data showed that a lure this size attracted the same no. of males as a calling female. 9002-86-2', 35746-21-5 8207 CA/096/204568H CA/159001 Michal J Ore Res. Inst., Prague Determination of carbon monoxide in thermal degradation products of polvmeric materials Fire Mater.,* VOL 5, ISS 4, 1981,149-52 JOURNAL ARTICLE Czech. 147 13 ENG FMATD 0308-0501 CBAC COPYRIGHT: CHEM ABS Carbon monoxide polymer thermal degrdn;Leather substitutes Polyurethane-coated textile, thermal degrdn. products of, carbon monoxide detn. in, temp, effect on Poromeric5Polyamides Thermal degrdn. products of, carbon monoxide detn. inJPolycarbonates Thermal degrdn. products of, carbon monoxide detn. injUrethane polvmers Cellular, thermal degrdn. products of, carbon monoxide detn. in, temp, effect on 630-08-05 9002-86-2! 9002-88-4*, 9003-07-0*, 9003-53-6*, 9003-56-9; 9011-14-7; 25035-04-5; 51280-99-0,* 81690-26-8 RNW 1690 110019 PVC PAGE 147 - 8207 - CA/096/168488W - CA/161010 - Becker-Birck J > Dellenbusch A ; Havemeister G - Abt. Hyg. Sozialhyg. Gesundheitswes. Christian-Albrechts-Univ., Kiel - Hygienic assessment of plastic swimming pool water covers - Zentralbl. Bakteriol., Mikrobiol. Hyg., Abt. 1, Orig. B5 VOL 174, ISS 5, 1981,443-52 - JOURNAL ARTICLE - Fed. Rep. Ger. - GER - ZAOMD - CBAC COPYRIGHTS CHEM ABS Plastic pool cover water quality PVC pool cover water quality Polyethylene pool cover water quality Chlorine consumption plastic pool cover Bacterid water plastic pool cover;Chlorides Water pollution by, in swimming pools, plastic pool covers in relation toJNitrates Water pollution by, in swimming pools, plastic pool covers in relation toJNitrites Water pollution by, in swimming pools, plastic pool covers in relation tojPhosphates Water pollution by, in swimming pools, plastic pool covers in relation toJPlastics In swimming pool ' 'ers, bacterid, and chem effects on water from? Pseudomonas orescens Growth of, in swimming pool water, plastic pool covers in relation toJSwimming pools Polyethylene and PVC plastic covers for, bacterid, and chem. effects from - 7440-44-0', 9002-86-2; 9002-88-4; 14798-03-9 - 8207 - CA/096/168073G - CA/160004 Wilson DC ; Young PJ ; Hudson BC ; Baldwin G - Waste Res. Unit, Harwell Lab., Harwell - Pigmented plastics in a municipal landfill site. Is this a significant source of cadmium pollution? - Chem. Ind. (London); ISS 23, 1981,843-4 JOURNAL ARTICLE UK 0X11 ORA ENG CHINA 0009-3068 CBAC COPYRIGHT! CHEM ABS Cadmium leaching waste plastic PVC waste cadmium leaching ABS waste cadmium leaching Pigment cadmium leaching waste Municipal landfill cadmium leaching>Plastics Waste, cadmium leaching from pigmented, in landfill sites;Waste solids Pigmented, cadmium leaching from, in landfill sites Plastics 7440-43-9; 9002-86-2; 9003-56-9 8207 * * END OF OFFLINE PRINT * # * # # RNW 1691