Document NwDwb698Ky2wz1mLywvgz298
Ceas 7 on
Ss27 e ho m FYI 2 0AR5D0.0-10327084
3M May 18,, 2000
FYI-00-001378
MR =2z 61%
s =
Rx 535a=
VIA EXPRESS MAIL
DDri.reCchtaorrles Auer Chemical Control Division UOfnfiitceedOSftaPtoelsluEtinovnirPornemveennttaiolnPArontdecTtoixoincAsgency R40o1omM4S0tr3eeEta,sStoTuotwhewres(tMail Code 7405) Washington, D. C. 20460
aonI;HlI
iy No a
Re: Information On Perfluorooctane
Sulfonates And Related Compounds
Dear Charlie:
Pursuant to our recent communications, 3M is enclosing additional
Aiipnnrffioolrrmm2a1at,tii2oon0n 0so0unpappneldrefmMleuanoytros4o,ic2ntfa0on0re0masltueiltotfenornss.autbeAmsgiaatintned,d
rteolaytoeud we are
p`rceovmipoouusnldys.undTehreceonvcelroosfedour providing this information on a
Voluntary basis as partof our continuing discussions with EPA regarding
fbluusoirnoecshsemiinsftorrym.atPiloena(sCeBIn)o;tweethaaltssoohmaeveofenthcilsoisnefdoramastainointiqzueadlivfeiressiaons ocofnCfBidIential
documents.
8
== aEmR
& 23 --3 2a5 2a
=
The enclosed information covers perfluorooctane sulfonates and certain
(PreMelraafrtlceuhdorc1o,oc2mh0pe0mo0i)uc.nadlSsspelIcinisfTtiehcdealinlEynT,vaitbrhloeenim1nefonoftr:tmhaetSiodouonrcccueomsve,enrDtsistenphteeirtfsloeidlo:lno,"wSiFunagltfecohAneanmtdiecdEaflfsects, at 12. = Perfluorooctane sulfonates, including CAS numbers 1763-23-1 (acid); 29081-56-
792(-a5m(mliotnhiiuummsaslatl)t.); 70225-14-8 (DEA salt); 2795-39-3 (potassium-salt); 29457-
= Perfluorooctanesulfonyl fluoride
Anngna
85000000010
Charles Auer May 18, 2000 Page 2
= Perfluorooctanesulfonamide
= Perfluorooctane sufonylamido (ethyl) acetate
= Perfluorodecanesulfonate
= Perfluorohexane sulfonate
= N-ethyl perfluorooctanesulfonamide
= N-methylperfluorooctanesulfonamide
= N-ethylperfiuorooctane sulfonamidoathanol
= N-methylperfluorooctanesuifonamidoethanol
= N-ethylperfluorooctanesulfonamidaocerytlhaytel
= N-ethylperfluorooctanesuifonamidaocerytlhaytel
= N-ethylperfiuorooctanesulfonamidoethylmethacrylate
= N-methyl perfluorooctanesuifonamidoethyl acrylate
previously
3M under
has provided you coverof our April
2w1i,th2i0n0f0oramnadtiMonayon4,pe2r0f0l0uolreottoecrts.aneWseuiafroenaetnecslosing
`cosnotmienuadidnigtfiiolneasleairncfho.rmaFtoironeoacnhpeorfftlhueorfooorcetgaoniengsurleflaotneadtecsolmopcoautneddsa,s tphaerteonfclooursed
information includes the following:
=
Copies of post-1976 studies and environmental science areas: (i)
certain other physical and
information relating to the chemical properties; (i)
following
`eencvotiorxoicnimtey.ntaFlorfaetaecahndstturdayn,sp3oMrt;ha(isi)pernevpiarroendmeantsaulmmmoanriytoirnintgh;e aHnPdV(i"vr)obust
ssuummmmaarryy"afdodrrmeasts.in3gMeaalcrheaodfythheasseparroevaisdeudnydoeur
with a general executive coverofour May 4, 2000
letter.
=
Copies of post-1976 health effects areas:
studies and certain other information (i) acute toxicity; (ii) genotoxicity; (i)
relating to the following repeated-dose toxicity:
e(ipvi)dpehmairomlaocgoy.kin3etMichsa;s(ivn)ctleurdaetdolaogdye,taainlded(vii)ndmeexdiocfatlhissuirnvfeoirlmlaatnicoenasnudbdivided by
each compound.
nnnnno
Charles Auer May 18, 2000 Page 3
=
Lists of all studies in progress study plans, where available.
and
planned
studies,
along
with
study
protocols
or
= Abibliographyofpre-1976 studies subdivided by each compound.
=
Athbaitbwlieogarraepphryovoifdaicnugtceotpoixeiscoitfy
skteuydiaecsutseubsdtiuvdiideesd(wbiythearcefhecreonmcpeotuondth,e
except HPV
guidance).
= Abibliography of published studies in 3M's possession.
= APnleiansdeenxootfestthuadtitehsisini3nd'esx hpaosssbeesesniosnubbmeiltiteevdedatsoCbBeI.in3thMeaFlIrFeaRdAydhoacskeptrovided
the the
Agency with a TSCA Section
list of all fluorochemical-related 8(e) docket.
submissions
made
by
3M
to
information as3aMppirsopcroinattien.uinAgsitysofuilererveiveiwewthainsdinwfiollrmsautipopnl,emweentastkhetheantcyloousebdear several points in mind:
=
The enclosed information in
information spans several each box with labeled fil
boxes. folders
We have organized the and indices to aid EPA's
review.
Tinofoernmsautiroen,thwateyaolusoaanrdeyaotutracshtiafnfgatroetahibslelettotearctcheesisndtihceesmocsotvepreirntginsetnutdies and
other information.
= nMuamnbyeorfwtihtehsatu*dT"i,es"Lr"eoferr*tFoC"thepretfeisxt. suAblstthaonucgeh oannlalyybsyisao3f Mtheprtoedsutcstuibdsetnatinfciecahtiaosn
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3inMdepxrotodupcrtovniudmebtehristiondfoertmeartmiionnebtahseecdomopno3sMit'isohnisotfortihcealtersetcsourdbsstkaenyceedatnodthheave
cpornotveixdte,dssapletcfiofircm iannfdorpmuartiitoyngroandet.he Pinldeeaxs,esnuoctheatshaptetrhceenttercmomopnostihteioinn,desxol"vweindte
range" refers to a toa higher purity
lower grade.
puFriintayllgy,raitdsehoofulthdebceormepcoougnndi,zeadntdha"tnparrordouwcrtange"
refers
fdoormnuoltactoinosntsithuatveecuervroelnvtepdroodvuecrtst.he years, and thus, some of the test substances
= Wasepahratvoefionucrlucdoendtisnouimneg afidldeirteivoineawl.stAusdiweseohnavpeerdfilsucoursosoecdta,nweesupllfaonnattoepsrloovciadteed Yneoaurwfiutthurien.foPrmlaetaisoen boen amdivxitsuerde,s hcoownetvaeinri,ngthpaetrwfeluoarloroecatdaynheasvuelfpornoavtiedsedinytoheu. with studies and other information on aqueous andor solvent solutions of
000003
Charles Auer May 18, 2000 Page 4
peenrcfllousoerdooicntfaonremastuilofnonlaitkeesw.iseAsintcolutdheesfsotruedgioeisnganredlacteerdtacinomoptoheurnddso,cutmheents on
cbootmhpotuhendcso.mpWoeunadrseansotweplrlovaisdionng atoquyeoouutsodaanyd,lohrowseovlevern,tisnoflourtmiaotnisonofotnheosteh.er
types of mixtures containing information with you.
these
compounds
and
would
like
to
discuss
such
=
Consistent sulfonates,
with 3M
the has
niontfoprrmoavtiidonedpryeovuiowuistlhyalplraonvaildyetdicoaln
perfluorooctane chemistry reports
on
these
rreelpaotretds cwohmipcohumnadys.proRvatehuesre,fwulethoaEvPeAeninclionsteerdprceetritnagincearntaaliyntisctauldicehse;mistry
understanding the `and biomonitoring
details data.
of
analytical
chemistry
methods;
or
verifying
human
= WHeernparnovdiedzeda p"rUesveioAunsldyEuxnpdoesrucroeveInrfoofrmoautrioApnriPrlo2fi8l,e"20o0r0"UlEetItPe"r tfoorOscar
perfluorooctane completed UEIP
sulfonates. Our forms for these
present intention is related compounds
to provide early next
you with week. 3M
needs
additional time ensure that the
tdoactlaariisfyacicnduursattreialanhdygpileanceedanind
other release information appropriate context,
to
= 2T0h0e0ineftotremraitnicolnuodendpdeorfcluumcernootcstarenleatsiunlgfotonaotnegsosienngt muencdhearnicsotviecrroefsoeuarrcMhabyy4,Dr.
eKnecnoWmaplalsasceesofthtehseeUrneilvaertseidtcyoomfpMoiunnndesso.taI.n
Please note addition, Dr.
that this research Marion Anders of
also the
rUneisveearrscihtyreolfatRioncghteospteerrfMleuodriocoacltaCneentseurlfiosnpaetrefsoarnmidntghceosmepraerlaattievdechmeemtiacbaollsi;sm
there are not documents yet available relating to this research.
000004
Charles Auer May 18, 2000 Page
other EPA staf3f.M Ilnootkhse fmoerawnatridmeto,dpilsecaussesidnog ntohte heensciltoasteedtoincfoonrtmaacttiomnewiwtihthyaonuyand questions.
Enclosures
Very truly yours
Hilts Q. SF gprs
WDiirlelcitaomrAo.fWEenpvpirnoenrm,enPtha.l,D Health, Safety
And Regulatory Affairs
Specialty am
Materials
Markets
Bldg 236-18-10
3M Center
St. Paul, MN 55144
(651) 733-6374 (phone)
(651) 733-1958 (fax)
E-mail: waweppner@mmm.com
000005
N-EtFOSE AlcoholBibliography
SynonFyIm34s22:, F225, FU 4835, FM4120, F 038, C-10
Physicaichomica properties
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Meme |s81a112y207177176.6s7."7,||| R"[vospeuowsetdosrurmmeumamnroey,n2] 1T7o19a7,7,||Rocoesitaasbumyempoaarwrys.2 T38s9e3 | Gen (ouna)
Jai consis
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psc suisonsotasorption eatinofto Boconconaion Potent or 422 rech Report Assopton of F342 onso
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N-MeFOSE Alcohol
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PhysicallChemical Properties [rechReport Sotuiiyof Fm3525
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tab | 102379 fiecnicaireports
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N-Ethylperfluorooctanesulfonamide = Ethyl Amide
Synonyms EF0SA, 1P0SA, U1484, P12 Pesce
PhysicaliChemical Properties
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Synonyms: FX-8
Physicachemica Properties [Watersoubity estimate (screen)
Tovnorestroryor ||comopwleesa ME. tab | Su1s18s, [[ERobTustusiucbmwkomrkcaesrhireqreuytesb,y
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000011
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Synonyms: FX-13, 81226, 0-1
PhysicalChamicl Propertios
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s[aDmetpelremi0na-t1ion of Physico-chemical Properties of Environmental Fate and Transpo
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000012
Perfluorodecanesulfonate, Ammonium Salt (PFDS)
Synonyms: FC-120, FC-121, LR J2904
Physicalchamical Properties
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000014
Perfluorooctane sulfonylamido(ethyl)acetate = PFOSAA
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Environmental Fate and Transport
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Expected Completion Dates for
Degradation and Transport Studies in Progress
Photolysis
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eptember, 2000
a
All studies underwayatthe 3M Env. lab
000017
Laboratory Environmental Studies in Planned and in Progress
Chomistry [stud PhysicalChomicat Properties
N-EtFOSE [Alcohol _ [Solubility in Water- in progress
DograadndaTratnsoponrt
Ecotoncoiony
[Conducted By Wid Intemational, Easton. MD
Expected [(pCaotmepletion sept. 2000
006018
Attachments to Letter to C. Auer dated May 18, 2000 Studies and Other Information on Certain
Perfluorooctane Sulfonate-Related Compounds
[r1 05F|retmaromsancmtony taonac
Acute Toxicity
1) `PTroixmiacroyloSgky,inRIirkreirtaLtaiobnorTaetsotriweist,hPTr-oj3e8c7t4Nion.A0l3b8in6oEBR0a1bb3i5t,s,3PMatRheofleorgeynacnedNo. T3874, April 14, 1986
2) T5-273,6037MARceufteerIennhcaelaNtoi.onT-T3ox6i0c7i,tyDeTcesetm,bBeursh19y,R1u9n84Research Center, Project No. 47-
3) AHaczulteetOornaLlaTbooxriactiotryieSstAumdeyr-icMae,thInocd.,, PSruomjemcatrNyo,.P4a0t7h0o3l9o8g3y,anOdctRoabewrD5a,t1a9A8p4pendix,
Genotoxicity
1) I2n54V1itCrooCM,icSrRobIiIonltoegmiactailonAasls,ayPrsojoefc3t MNoC.oLmSpCan44y4C2-o1m6p,o3unMdsReTf-e2r5en4c0eCNoo.C Ta-n2d5T41-.1 (FC-3452), August, 1979
Ongoing Research/Study Protocols
1)
Protocol, Pharmacokinetic Laboratory, 3M Reference
SNo.tT-ou7f09Pd8O.S1yF
in
Rats,
3M
Strategic
Toxicology
Pre-1976 Studies (bibliography only) 1) S5k0i9n12I4m1i,ta3tiMonRaenfderEeyneceIrNroit.atTi-o1n3S2t9u,dySeRpetpeomrtb,erW9A,R1F975Institute, Inc., Project No. 2). APrcoujteectVNaop.or66I3n-ha0l7a5t1i3o,n T3oMxiRceifteyrSetnucdeyNion.RTat-s1,32I9n,dusOtcrtioableBri2o3-,Te1s9t7L5aboratories,
000019
,
Attachments to Letter to C. Auer dated May 18, 2000
PerSftluudoireosoacntadnOetShuelrfoInnaftoer-mRaetliaotnedoCnoCmeprtoauinnds
[zrosa |Perfluorooctanesulfonamide Acute Toxicity
1) Acute Oral Toxicity Screen with T-3421 in Albino Rats, Safety Evaluation Laboratory, Riker laboratories, Inc., Project No. 0883AR0287, 3M Reference No. T3421 (KTZ-15), January 17, 1984
2) Acute Ocular Irritation Test with T-3421 in Albino Rabbits, Safety Evaluation Laboratory, Riker laboratories, Inc., Project No. 0883EB286, 3M Reference No. T3421 (KTZ-15), August 24, 1983
3) Primary Skin Irritation Test with T-3421 in Albino Rabbits, Safety Evaluation Laboratory, Riker laboratories, Inc., Project No. 0883AR0288, 3M Reference No. T3421 (KTZ-15), August 9, 1983
Studies in Progress
1) DPreortiovcaotli,veFsec[eNs-EMteFtOhSoEd,DPeFvOeSl,opamnednFtOMSeAt]a,bo3liMsmStSrattuedgyicfoTroxPiercfolluoogryooLcatbaonreastuolrfyo,nate
Study Nos., T-636.17; T-6295.21; T-7132.3; ST-41, In-Life Start DateNovember 22, 1999, In-Life End Date November 24, 1999 2) Protocol, Pharmacokinetic StudyofPerfluorooctane Sulfonamide [FOSA] in Rats, 3M Strategic Toxicology Laboratory, Study Nos., T132.2; ST-39, In-Life Start Date October 4, 1999, In-Life End Date Novembe2r, 1999 3) Protocol, Cell Proliferation Study with N-Ethyl Perfluorooctanesulfonamido Ethanol (N-EtFOSE; 3M T-6316.11), Perfluorooctane Sulfonic Acid Potassium Salt(PFOS; 3M T-6295.16), and N-Ethyl Perfluorooctanesulfonamide (PFOSA 3M T-7091.1) in Rats, Pathology Associates Intemational, Study No. 1132-100
000020
Attachments Studies
to Letter to C. Auer dated and Other Information on
May 18, Certain
2000
Perfluorooctane Sulfonate-Related Compounds
3. PFOSAA | Perfluorooctane sulfonylamido (ethyDacetate
Acute Toxicity
1)
Acute Oral No. T-1983
Toxicity ~ Rats, Biosearch, Inc., (FC-128, potassium salt 100%,
Project No. 77-1108A, solid), January 5, 1978
3M
Reference
2)
Acute Oral Toxicity -- Rats, Biosearch, No. T-2001 (FC-128), January 6, 1978
Inc., Project No. 77-1274, 3M Reference
3)
Primary Eye Irritation Reference No. T-2001
S(FtCu-1d2~y8)R,abJbaintusa,rByio6,se1a9r7c8h,
Inc.,
Project
No.
77-1127A,
3M
4) RPerfiemraernycSekNion.ITit-a2t0i0o1n(SFtCu-d1y28-),RaJbabnitusa,ryBi6o,s1e9ar7c8h, Inc., Project No. 77-1274, 3M
5)
An Acute Inhalation Project No. 78-7186,
Toxicity StudyofT-2307 CoC in the 3M Reference No. T-2307 (FC-128),
Rat, Bio/dynamics, February , 1979
Inc.
`Additional Acute Toxicity Studies Not Submitted (Bibliography only)
1)
Acute Oral No. T-2081
T(FoCx-1i29c,--iaRpatptrsyo,xBiimoasteealrych4,0-In5c0.,%PirnojseocltutNioo.n),78M-a1r1c9h12,,
3M Reference 1978
2)
Primary Eye Irritation Reference No. T-2081
Study -- Rabbits, Biosearch, (FC-129), March 2, 1978
Inc.,
Project
No.
78-1914,
3M
3)
Primary Skin Reference No.
Irritation T-2081
Study -- Rabbits, (FC-129), March
Biosearch, 2, 1978
Inc.,
Project
No.
78-1191A,
3M
4) Acute Oral Toxicity Screen with T-3290CoC in Albino Rats, Safety Evaluation 3La2b9o0ra(t4o0ry%, KRi'kPerFOLaSbAorAationri3es%, EIntcO,H,Pro1j7ec%t NIoP.A0a8n8dA4R00%362H,;03,ML-R6e7f7e8r,eFn-c6e8N7o3., TL-ot 501), November 5, 1982
5) LParbiomraartyorSyk,inRiIkrerirtaLtaiboonrTaetsortiwcist,hInTc-, 32Pr9o0jCecotCNion.A0l8b8iEnoB0R4a2bb3i,ts3,MSaRfeefteyrEevnacleuaNtoi.onT-
3290 501),
(40 % K'PFOSAA October 15, 1982
in
3
%
EtOH,
17
%
IPA
and
40
%
Hy0,
L-6778,
F-6873,
Lot
6) LAacbuotreatOocruyl,arRiIkrerirtaLtaiboonrTateosrtiweis,thInTc-.,3P2r9o0jCecotCNoin. A0l8b8iEnBo0R4a2bb4i,ts3,MSaRfeefteyrEevnacleuNatoi.oTn-
000021
-3-
i
AttacShtmuednitess atondLeOtttehrertoICn.foArumeartidoanteodn MCearyta1i8n, 2000 Perfluorooctane Sulfonate-Related Compounds
3290 501),
(40 %K'PFOSAA October 26, 1982
in
3
%
EtOH,
17
%
IPA
and
40
%
Hy0,
L-6778,
F-6873,
Lot
Genotoxicity
1) BBaicotteersitailngReCevnetresre,MCuhteamtiicoanlTseIsntsopfevc-ti1o,nHaintda TReessteianrgchInsltaibtourtaet,orSiteusd,yCChoedmei:caKlO1-
51801%5,inRespoolurttioNon.ofTw-a4t66e3r,an3dMorRgeafneircensocleveNnot.),T-O6c6t6o8b.e1r,,
FC-129 1996
(approximately
40-
2) 3In29Vi0tCrooCM,icSrRoIbiIonltoegmiactailonMaul,taPgreonjiecctitNyo.As3s1a4y5s,of3M3MReCfoermepnacneyN'os.CTo-m3p2o90un(d40T%-
K'PFOSAA in 3 November, 1982
%
EtOH,
17
%
IPA
and
40
%
H0, L-6778, F-6873, Lot 501),
Pharmacokinetic Studies
1) E2v8aDlueartmiaoln Pleabrocruattaonreyo,uRsikAebrsoLrapbtoiroatnoSriteusd,yIwnic.t,hPFrCoj-e1c2t8Noin.A0l9b7i9nAoBR0a6bb2i9t,s,3SMafety Reference No. T-3991, March 15, 1981
2) S2a8feDtayyEDvealrumaatlioPnerlcabuotraanteooruy,s RAibkseorrpLtaiboonraSttourideysw,iItnhc.F, CP-ro1j2e9ctinNoA.lb0i9n7o9RAaBb0bi6t2s7,, 3M Reference No. T-3989, March 14, 1981
3) TFi-n6a0l51ReaponrdtT~-6A0n5al4ytinicRaalbbSittusd,y:3SMinEgnlvei-rDoonsmeenDtearlmaLalboArbastoorrpyt,ioSntu/dTyoxNioc.itAyDSMtuTd-y of 301M31R9e5f.e1r,einnceviNvoos.StTu-d6y05Re1fe(rFeCn-c1e29Not.reHatWedIf6ab3r2i9c-)1a3n3d(TH-a6z0l5et4o(nFWCi-s1c2o9nssiolnu,tiInocn.)),, November 22, 1995
4) oFfinTa-l6R0e5p4oritn,RAanbabliyttsi,ca3lMReEpnovritroannmdenStianlglTee-cDhonsoelIongtyra&veSneoruvsicPehsa,rmIanc-oVkiivnoeSttiucdSytudy
Reference No. HWI#6329-138, 129, November 22, 1995
Study No.
AMDT-122094.2,
3M
Reference
No.
FC-
Studies in Progress 1) SCtorraptoergaicteToTxoixcioclolooggyyLaSbtourdaytoOruytl,iJnuel,y,FC1-919289 Preliminary ADME Screen in Rats, 3M
000022
ey
Attachments to Letter to C. Auer dated May 18, 2000 Studies and Other Information on Certain
Perfluorooctane Sulfonate-Related Compounds
Pre-1976 Studies (bibliography only) 1) Skin and Eye Irritation Assay Report, WARF Institute, Project No. 2031046, 3M
Reference No. FC-128, April 24, 1962 (plus December 29, 1966 lettercontaining individual eye scores)
000023
5.
'
Attachments Studies
atondLeOtttehrertoInC.foArumeartdioanteodn
MCearyta1i8n,2000
Perfluorooctane Sulfonate-Related Compounds
4. PDS Perfluorodecanesulfonate
Acute Toxicity
1) AFminearlicRae,poIrntc,.,A3cuMteReDfeerrmeanlceToNxoi.ciTt-y41S0t2u,dySainmpRlabebNiot.s,TH8a3z7e3lt8o9n-4L1ab0or7a5t4o,riJeasn.uary 21, 1988
2) FInicn.a,l3RMepoRretf,erAecnucteeNOor.alTT4o1x0i2c,itSyaSmtpuldey Nino.RaTt8s,37H3a8z9e-lt4o1n0L7a5b4o,raJtaonruiaersyA2m5e,ri1c9a8,8
3)
FLianbaolraRteoproirets,
APmreirmiacray,
EIynce.,I3itMatRieofne/rCoernrcoesNioo.n
Study in T-4102,
SRaabmbpiltes,NoH.azTe8lt3o7n389-410
754, January 20, 1988
4) FLianbaolraRteoproirets,APmreirmiacray,DIencr.m,a3lIMrrRietafteiroennCcoerNroo.siTo-n41S0t2u,dySainmpRalbebiNtos.,TH8a3z7el3t8o9n-410 754, January 21, 1988
Genotoxicity
1) MMuitcargoesnoimceitRyeTveesrtsewiMtuhtTa-ti6o3n57Asisnatyh,eCSaolmmionngelHlaazl--etEosnc,heIrnci.ch(iCaHcVo)li,/PMraojmemcatlNioa.n. 17387-0-409, 3M Reference No. T-6357, FC-120, April 1, 1996
2) HMauztlaegteonni,ciItncy.T(eCstHVo)n,TP-r6o3j5ec7tiNnoa.n1I7n3V87i-v0o-4M0o9u,s3eMMiRcerfoenruecnlceeusNoA.ssTa-y6,35C7o,miFnCg-.120, April 23,1996
Pharmacokinetic Studies 1) oFfinTa-l6R0e5p2oritn,RAanbabliyttsi,caHlazRleeptoorntWainsdcoSnisnignl,e-IDnco.s,ePDroejremcatlNoAb.sHorWpIti6o3n2/9-T1o3xi5c,i3tyMStudy
Reference No. FC-120, T-6052 (0.02 % in water), November 20, 1995 2) HSaiznlgelteo-nDoWsiesDcoenrsmianl, IInntcr,aPvreonjoeucstPNhoa.rmHaWcoIki6n3e2t9i-c13S4t,ud3yMofRTef-e6r0e5n2ceinNRoa.bbTi-t6s0,52
(0.02 % in water), November 20, 19995
000024 6
AttacShtmuednitess atondLeOtttehrertoICn.foArumeartidoanteodn MCearyta1i8n, 2000 Perfluorooctane Sulfonate-Related Compounds
Pre-1976 Studies (bibliography only)
1)
LAacbuotreatOorrailesT,oxInicc.i,tPyrSojteucdtyNwoi.th60T1--100513994i,n
Male Albino Rats, 3M Reference No.
Industrial Bio-Test T-1019, August 6,
1974
2) 4S0k5i3n8I6n3i,tat3iMon,ReEfyeereInmicteatNioo.n,TA-c9u92t,e MOraayl 2L4D,S01,97W4ARF Institute, Inc., Project No.
3) `ATceustteLaObroarlatCohroileisn,eIsntce.r,aPsreojSetcutdNyo.wit6h01T--015031994,in3MMalReefAelrbeinncoe RNaot.s,TI-n1d0u1s9t,riaAlugBuisot- 6, 1974
000025 -7-
oo
Attachments to Letter to C. Auer dated May 18, 2000
PerSftluudoireosoacntadnOetShuelrfoInnaftoer-mRaetliaotnedoCnoCmeprtoauinnds
[P s. HS|Perfuorohesane sulfonate
oSneee icotnefmidiennctliuadlinsgubPmFiHssSiodnatuander letter of May 15, 2000 from Dr. John L. Butenhoff for
000026
Attachments toLetterto C. Auer dated May 18, 2000 Studies and Other Information on Certain
Perfluorooctane Sulfonate-Related Compounds
6. N-EtFOSA| N-ethyl perfluorooctanesulfonamide
Acute Toxicity
1) Final Report, Acute Ocular Irritation Test with T-3608 in Albino Rats, Riker Laboratories, Inc., 3M Reference FX-12, Study No. 0984EB0367, September 5, 1984
2) Final Report, Primary Skin Irritation Test with T-3608 in Albino Rats, Riker Laboratories, Inc., 3M Reference FX-12, Study No. 0984EB0368, August 13, 1984
3) Final Report, Acute Oral Toxicity Screen with T-3066CoC in Albino Rats, Riker Laboratories, Inc., 3M Ref. No. FX-12, Study No. 0981AR0146, July 13, 1981
Acute Toxicity Studies Not Submitted (Bibliography Only) 1) Final Report, Acute Oral Toxicity StudyofT-6684 in Rats (QECDGuidelines),
Corning Hazelton Inc., 3M Ref. No. L-14394 (slurry), Study No. CHW 61101149, January 31, 1997
2) Final Report, Primary Dermal Irritation/Corrosion Study of T-6684 in Rats (OECD
Guidelines), Coming Hazelton Inc., 3M Ref. No. L-14394 (slurry), Study No. CHW 61101150, January 31, 1997
3) Final Report, Primary Eye Irritation/Corrosion Study of T-6684 in Rats (OECD Guidelines), Coming Hazelton Inc., 3M Ref. No. L-14394 (slurry), Study No. CHW
61101151, January31, 1997
clonic
1) Final Report, Protocol and two amendments, Mutagenicity Test on T-6294 in an In
Vivo Mouse Micronucleus Assay, Coming Hazelton, Inc., Study No. 1785-0-455, May 10, 1996 Previously submitted with May 4, 2000 letter, Advanced Bioanalytical Services, Inc., Analytical Report, Additional Characterization of Metabolites ofT-6292, T-6293 and T6294 from Rat and Human Hepatocytes by TurbolonSpray LC/MS and LC/MS/MS. Semi-Quantitative Analysis of T-6295 in Rat and Human Hepatocytes Incubated with T6292, T-6293 and T-6294 by LC/MS/MS, January 28, 1998, Report 98AGKPO1.3M
0600027
'
AttacShtmuednitess atondLeOtttehrertoICn.foArumeartidoanteodn MCearyta1i8n, 2000 Perfluorooctane Sulfonate-Related Compounds
Mechanistic 1) TN.-JE.thCyrlopsesrfalnudorRo.oGc.taSncehSnuellflmaannonm,idMee(cNhEaPnFiOsSmo),faTnodxiictistmyetoafbaolUintieqpueerfPleusotriociodcetane
ASbusltfroancatmfirdoem(P1F98O9S)SotcoiIestoylaotfeTdoRxaibcboiltoRgeynMaeletCionrgt,ical Mitochondria (RCM),
MPreetvaibooulsilsymsuobfmTi-t6t2ed92wi(tn-hcMthayyl F4,OS2E0)0,0Tl-et6t2er9-3Q(una-leitthaytlivFeOISnEvepsthiogsapthiaotnoefdtihaemImnonViiturmo
ssaullif(oensatteer)),byT-R6a2t9a4n(dn-Heuthmyal npeHrefplautoorcoyotcteasnUessiunlgfoInoanmSipder)ayanLdCT/-M6S29a5nd(pLerCf/lMurSo/ocMtSa,ne.
Advanced Bioanalytical Services, Inc, 96ADEMOI.3M, November 12, 1996
[Preliminary]
Analytical
Report,
Report
APnraelvyitoiucsallyRseupbomritt,teAdddwiittihonMaalyCh4a,ra2c0t0e0rilzeatttieo-rnoAfdvMaetnacbeodliBtieosaonaflyTt-i6c2a9l2,SeTrv-i6c2e9s3, aInnc.d, TS6e2m9i4-QfuraonmtiRtaattiavnedAHnualmyasnisHoefpaTt-o6c2y9t5esinbRyaTtuarnbdolHounmSparnayHeLpCat/oMcSytaensdILncCu/bMaSte/dMwSi.th T6292, T-6293 and T-6294 by LC/MS/MS, January 28, 1998, Report 98AGKPO1 3M
Analytical
1)
Analytical 1993
and
Research
Properties
--
3M
Industrial
Hygiene
Laboratory,
January
000028
Attachments to Letter to C. Auer dated May 18, 2000 Studies and Other Information on Certain
Perfluorooctane Sulfonate-Related Compounds 6. N-EtFOSA| N-ethyl perfluorooctanesulfonamide Bibliography Showing Studies in 3's Possession Believed To Be In FIFRA Docket.
REDACTED
000029 |
Attachments Studies
atondLeOtttehrertoICn.foArumeartidoantoend
May 18, Certain
2000
Perfluorooctane Sulfonate-Related Compounds
7. N-MeFOSA |N-methyl perfluorooctanesulfonamide
AcuteToxicity 1) LAacbuotreatOorrailesToAxmiecriitcya~,MIenct.h,oPdr,ojSeuctmmNao.ry5,05P0a3th4o9l9o,g3y MQAReUfeRreepnocret,NoH.azTl-e3t7o5n2 (F-
7075-4, water-washed, acid washed), July 12, 1985, with Protocol 2) LParbiomraartyorDieersmAamlerIrirciat,atiIonnc.~, PMreotjheocdt,NoS.um5m0a5r03y5,0P0a,th3oMloRgeyfeQrAenUceReNpoo.rtT,-3H7az5l2e(tFo-n
7075-4, water-washed, acid washed), June 24, 1985, with Protocol 3) LParbiomraartyorEiyees AIrmreirtiactai,onIncM.,etPhroodj,ecStuNmom.ar5y05,0P3a5t0h1o,lo3gMy QReAfeUreRnecpeorNto,.HTaz-l3e7t5o2n(F-
7075-4, water-washed, acid washed), June 24, 1985, with Protocol 4) MAectuhtoedO,raSluTmomxaircyit;yP--riMmeatrhyodE,yeSuIrmrmiatartyio,n ~PaMtehotlhoogdy,;SPurmimmaarryy;DeQrmAaUl RIerrpiotratt;ionRaw.
RDeaftearAepnpceenNdoi.x,T-H3a7z2le7t(oFn-L1a0b0o3r4a,toLroites7,Admiestriilclaed,wIindce,-rParnogjeec)t, NMoa.y570,201294857,3,wi3tMh Protocol 5) AEcxupetreiOmreanltTNoox.ic0i9ty81SAcRre0e1n45wi,tMhaTy-31056,51C9o81C in Albino Rats, Riker Laboratories, Inc., Genotoxicity 1). NIno.ViLtSrCo-M3i1c4r5o,bi3olMogRiecfaelrMeuntcaegNeon.icTi-t3y7A5s2sa(yFs-7o0f7T5-43,75w2a,teSrR-IwaIsnhteedrn,ataicoindalw,asPhreojde)c,t June, 1985 2) NIno.ViLtSrCo-M3i1c4r5o,bi3olMogRiecfaelrMeuntcaegNeon.icTi-t3y7A2s7sa(yFs-o10f0T3-43,7L2o7t,7S,RdIistIinltleemdawtiiodnea-lr,anPgreo)j,ect March, 1985
000030
Attachments to Letter to C. Auer dated May 18, 2000 Studies and Other Information on Certain
Perfluorooctane Sulfonate-Related Compounds
8. N-EtFOSE alcohol | N-ethyl perfluorooctane sulfonamidoethanol Acute Toxicity 1) Corrected Final Report, Acute Inhalation Toxicity Study in Rats, 3M Reference No.
T-29911T, Hazelton Laboratories America, Inc., Study No. 154-157, February 2, 1981
Genotoxicity
1) Final Report, Mutagenicity Test on T-5710 in an n Vivo Rat Micronucleus Assay,
Hazelton Washington, Inc., Study No. 15516-0-454, April 23, 1993
2) Final Report, Genotoxicity Test on T-5710.1 in the In Vivo/In Vitro Unscheduled
DNA Synthesis and Cell Proliferation in Rat
Study No. 15516-0-494, September 14, 1993
Liver
Cells,
Hazelton
Washington,
Inc.,
3) Final Report, Mutagenicity Test on T-6292 in an /n Vivo Mouse MicronucleusAssay, Hazelton Washington, Inc., Study No. 17384-0-455, May 2, 1996, with Protocol and Protocol amendments
4) Evaluationofthe Mutagenic Activityof T-6906 in an In Vitro Mammalian Cell Gene Mutation Test with L5178Y Mouse Lymphoma Cells, NOTOX Study No. 223458, 3M Reference No. FM-3923
a) Final Report, December 22, 1998 (see letter below)
b)
Letter from Ste
NOTOX study
ve R.
and c
Haworth,
oncluding
Ph.D.,
it was
Covance Laboratories,
technically inadequate
reviewing
and should
the
be
repeated
Note: 3M is repeating the study
Repeated-Dose Toxicity
1)
Final Report,
Research and
NDienveetlyoDpmaeynStuCboarcpuotreatRiaotn,ToSxtiucdiytyNoS.tu1d3y7o-n08F6M,-N3o4v2e2m,bIenrte1r0n,at1io9n7a8l
000031
13.
|
AttacShtmuednitess atondLeOtttehrertoInC.foArumeartidoanteodn MCearyta1i8n, 2000 Perfluorooctane Sulfonate-Related Compounds
2) FInitnearlnaRteipoonratl,RNeisneeatrychDaayndSuDbeavceultoepmRheenstuCsorMpoonrakteiyonT,oxSitcuidtyyNSot.ud1y3,7o-n08F8M,-J3a4n2u2a,ry 16,1979
3) Two-Year Dietary Study a) RFelpuoorrto,chVeomliucmaelsFM1--53,9T2w4oinYeRaatrs,OrRailke(DriLeatb)oTroatxoirciiest,/yICnacr.,ciSntougdeyniNcoi.ty Study of 0281CRO012, August 29, 1987, Conducted during April 1981 - May 1983 b)oRfeFplourotrAomcheenmdimceanltFMNo-.3912, 4TwinoRYatesa,rROirkaelr(LDaibeotr)atTorioes,xI/nciC.a,rScctiundioygeNtnoi.ciyty Study 0281CRO012, October 25, 1988 )oXfenDoesceLmebtteerr d10a,te1d9M90ay[re242,y1e9a9r1cawnictehratsttuadcyh]m,enFto:o3d MAdRdietsipvoensPeettiotiFonDNAosL.etter 0B4197 and 0B4206 d) PinatRhaotsl,ogPyatRheovlioegwy oAfssRoecpioartteesdInTtuemmoartiigoenanle,siNsovineambTewro25Y,ea1r99S8tudy of FM-3924. ) Analytical on retained sample ) SRteuvdiyeowfbyFlDuro.roWcihlelmiiacmalH.FMBut3l9e2ro4finTRwaotsYear (Diet) Tox/ iCarcciniogetnicyity
4) Ongoing 2-Year Study a) SNaurmrmoawrRyaRnegpeor(t98o.f1W%e)eNk-E5t3h,yl10P4e-rfWleueokroDoicettaanrysCualrfcainnooagmeindiociEttyhaSntouldyinwRiatths, f3iMnalRreefpeorretnecxepNeoc.teTd-f6a3l1l62.010,0C)ovance Laboratories, 6329-212 and ~228 (draft
Pharmacokinetic Studies 1) S1y9n8t1hesis and Characterizationof N-Ethyl FOSE '"C, Riker Laboratories, March 17, 2) FDiisntarliRbeuptoirotn,aAnbdsEolripmtiinoantiaonndofBiCoatrrabnosnf-o1r4maatfitoernoAfdmNi-nEitsthryaltFioOnSoEfaN-nEdtThiyslsuFeOSE -
HC in Feed, Riker Laboratories, Inc., January 19, 1983
000032 -14-
AttacShtmuednitess atondLeOtttehrertoICn.foArumeartidoanteodn MCearyta1i8n, 2000 Perfluorooctane Sulfonate-Related Compounds
MPreetvaibooulsilsymsoufbTm-it6t2e9d2wi(tnh-cMthayyl F4O,S2E0)0,0Tl-et6t2er93--- (Qnu-acltihtyaltiFvOeSIEnvepshtoisgpahtaiotneodfitahmemIonnViiutrmo ssaulltf(oensattere))),bTy-R6a2t9a4n(dn-HcuthmyalnpeHrefplautoorcoyotcteasnUessiunlgfoInoanmSipder)ayanLdC/T-M6S29a5nd(pLeCrf/lMuSro/oMcSia,ne 9Ad6vAaDnEcMeOd1B.i3oaMn,alNytoivcealmbSeerrvi1c2e,s,19I9nc6., [Preliminary] Analytical Report, Report
Previously Analytical
Rseupbomritt,teAdddwiittihonMaal yCh4a,ra2c0t0e0rilzeatttieo-rnoAfdvMaetnacbeodliBtieosaonfalyTt-i6c2a9l2,SeTr-vi6c2e9s3,
Inc., and T-
S6e2m9i4-QfuraonmtiRtaattiavnedAHnualmyasnisHoefpaTt-o6c2y9t5esinbRyaTtuarnbdolHounmSparnayHeLpCat/oMcSytaensdILncCu/bMaSt/edMSw.ith T-
6292, T-6293and T-6294 by LC/MS/MS, January 28, 1998, Report 9SAGKPO1.3M
`Mechanistic 1) HFainzaelltRoenpoWrats,hAinnagltyosni,soInfc.T,-S5t8u7d7yiNnoa.C1e5l4l-P2r0o8l,if3erMatRioenfeArsesnacyeiTn-5Ra8t77Li(vweirdeCerllasn,ge
PetrhoytlocFoOlSAEd)d,eFnMd-u3m9,24K,eyLotto 5F4C7,AlLc-o1h3o2l02T,oNxoSvaemmpbleers 1(,in1c9l9u4d,inwgit5h87P7r)o,toacnodl and Analytical data
Teratology
1) Oral (Gavage) Developmental Toxicity StofuN-Ed(FOySE in Rats
4)
3FiMnalReRfeeproerntc,eONroa.l
(TG-a63v1a6g.e7),DDeevceelompbmeernt1a7,l
Toxicity 1998
Study
of
N-E(FOSE
in
Rats,
b)
oSfuNm-mEaArFyONS-EEtifnoRsaetsR,at3TMerRaetfoelroegnyc,eONroal.
(Gavage) T-6316.7
Developmental
Toxicity
Study
2) Oral (Stomach Tube) Developmental Toxicity Study ofN-EtFOSE in Rabbits
@) iFninRaalbbRietpso,rt3,MOrRaelfe(rSetnocmeacNho.TuTb-e63)1D6e.v8e,lJoapnmueanrtyal11,To1x9i9ci9ty Study ofN-EWFOSE
b) TSouxmimciatryyStNu-dEytoFfONS-EERXaFbObiStETienraRtaoblboigtys,, 3OrMalR(efSetroemnaccehNTou.beT)-6D3e1v6e.l8opmental
3) Teratology StudiesofT-2999 (FM-3924) in Rabbits
000033 5.
Attachments `Studies
to Letter to C. Auer dated and Other Information on
May 18, Certain
2000
Perfluorooctane Sulfonate-Related Compounds
&) FEivnaalluaRteipoonrtL,abOorraaltoRrayn,geRfiiknedreLraSbotruadtyoorfieTs,-2In9c9.,9CStouCdyinNPor.eg0n6a8n0tRRBa0b0b1it9s,,JSuanfeety 25,1981
b) FSianfaeltyReEpvoarltuaatnidonPrLoatboocroalt,orOyr,alRiTkeerratLoalboograytSotruiedsy,oIfncT.-,2S9t9ud9yCoNoC.in06Ra8b1bTiBt0s,212, 3M Reference No. FM 3924 (88% ethyl FOSE), January 7, 1982
)
3M Intemal Correspondencre alcohols being used in Ricker to WC McCormick, dated December 10, 1980
Riker
studies,
from
DR
d) Analytical Analysesof SuspensionofFM-3924, Internal Memo, from TR Mathisen to EG Gortaer, dated April 8, 1981
)
3M Intemal 1982
Correspondence,
Analytical
Evaluation
of
FM-3924,
dated
June
22,
4) Oral Teratology Study ofFM-3422 in Rats
4) FLianbaolraRteoproyr,t,RiOkrearlLTaebroartaotloorgiyesS,tIundc.y,oSftFudMy-3N4o.2206in80RTatRs0,0S1a0f,etJyanEuvaarlyua2t2i,on1981
b)
3M Internal Correspondenrce alcohols being used in Ricker to WC McCormick, dated December 10, 1980
Riker
studies,
from
DR
5) Teratology Studies ofT-2999CoC (FM-3924) in Rats
4) FEivnaalluaRteipoonrtL,abSopreactioalryL,eRniskeOrraLlabToerraattoorlioegs,y ISntcu.,dyStoufdTy-N2o9.9096C8o0CTiRn0R0a2t0s,, S3aMfety Reference No. FM-3924, December 22, 1981
b) F`iTnwaolSRterpaoinrstoafnRdatPsr,otSoacfoelt,ySpEevcailaulatLieonnsLOarbaolraTteorrayt,oRliokgeyrSLtaubdoyraotforTi-e2s,99In9cC.,oC in Study No. 0681TR0362, July 20, 1982
)
3M Intemal Correspondence re alcohols being used in Ricker to WC McCormick, dated December 10, 1980
Riker
studics,
from
DR
d) Analytical Analyses of SuspensionofFM-3924, Internal Memo, from TR Mathisen to EG Gortner, dated April 8, 1981
) 3M intemal correspondence re analytical analysisofFM-3924, from EG Gorter to RM Payfer, dated June 22, 1982
000034 -16-
AttacShtmuednitess atondLeOtttehrertoICn.foArumeartidoanteodn MCearyta1i8n, 2000 Perfluorooctane Sulfonate-Related Compounds
6)
DMeevmeloopfmreonmtEsGtoLDaamtber,edcahttedtoNRoivkeemrbSetrud6y,
Files 1981
re
Fetal
Lens
Artifact
--
Summary
of
FPerretviliiotuys,lDyesvueblmoiptmteendttaolTaSndCAPerSienadtoaclk/ePto,stFniantaallRReepporrto,duCcotmiboinnTeodxicOriatly S(tGuadvyagoef)
N-EtFOSE in Note: weight
gRaaitns,ef3feMctRseifneFr,engceeneNroa.tiTo-n6c3u1r6r.e5n,tlJyunbeei3n0g,
1999 reanalyzed.
Report
may
require
amendment.
StuIdnPirogeresss
1) LPraobtoorcaotlo,ryN,-SEttuFdOySNEo.BiTl-e6M3e16t.h1o5d; DSeTv-e3l0,opImne-LnitfeinStRaartts,Da3tMe ASturgautsetgic12T,o1x9i9c9o,loIng-yLife End Date August 20, 1999
2) DPreortiovcaotli,veFsec[eNs-EMteFtOhSoEd,DPeFvOeSl,opamnednFtOMSeAtJa,bo3liMsmStrSattuedgyicfoTroxPeircfolluoogryooLcatbaonreastuolrfyo,nate
Study 1999,
NIno-sLi,feT-E6n3d6.D1a7t;eTN-6o2v9e5m.b21e;r
T-7132.3; 24, 1999
ST-41,
In-Life
Start
Date
November
22,
3) (PrNo-toEcFoOl,SECe;ll3PMroTli-f6e3r1a6t.i1o1n)S,tPuedryflwuiotrhoNo-cEtatnheylSuPlefrofnliucoArcoiocdtPaonteassuslifounmaSmaildto(EPtFhOaSn;ol
3M T-6295.16), Rats, Pathology
AasnsdocNi-aEttehsylInPteermfatliuoonraolo,ctSatnuedsyulNfoo.na1m1i3d2e-1(0P0FOSA
3M
T-7091.1)
in
Pre-1976 Studies (bibliography only)
1)
Final Report, Oral LD 50 Study No. 4043911, June
(4 levels), 12, 1974
3M
Reference
No.
T-961,
WARF
Institute,
Inc.,
2)
Final 1260,
RIenpdoursttr,iaAlcuBtieo-VTaepstorLaIbnohraaltaotriioens,ToIxnicc.,itJyulSyt2u1d,y
in Rats, 1975
3M
Reference
No.
T-
3)
Final 1259,
RIenpdousrttr,iaAlcuBtieo-VTaesptorLaIbnohraaltaotriioensT,oIxnicc.,itJyulSytu21d,y
in Rats, 1975
3M
Reference
No.
T-
4) F5i0n6a0l08Re0p,or3tM, SRkeifneraenndceEyNeo.liTm-it1a2t6io0n,SJtuundey,17W,A1R97F5 Institute, Inc., Study No.
5) F5i0n6a0l07Re9p,or3tM, SRkeifneraenndceEyNoe.IrTr-i1ta2t5i9on,SJtuundey,17W,A1R97F5 Insitute, Inc., Study No.
000035 5.
AttacShtmuednitess atondLeOtttherertoICn.foArumeartidoanteodn MCearyta1i8n, 2000 Perfluorooctane Sulfonate-Related Compounds
9. N-MeFOSE alcohol | N-methylperfluorooctane sulfonamidoethanol
Acute Toxicity
1)
Acute (75%
Oral Toxicityin 25% CaCOy),
Rats, Biosearch, Inc., Study No. 78-1161A,
3FeMb.Re2f,.1T9-728038CoC
(L-4309,
FC-5160)
2) 4P3r0i9m,arFyCE-5y1e6I0r)ri(ta7t5io%n iSntu2d5y%~CRaabCbOit)s,, BSitousdeyarNcoh., 7In8c-.,1316M1,RefF.ebT.-22,013987C8oC (L3) 4P3r0i9m,arFyC-Sk5i1n60I)rri(t7at5i%oninSt2u5d%y~CaRaCbObyi)t,s,SBtiuodsyeaNroc.h,78In-c1.1,631AM,RFeefb..T2-,21093788CoC (L4) EAxcpuetreiOmreanltT0o9x7ic9iAtRy0S0c3r7e,enSweiptthemTb-e2r52764,C1o9C79in Albino Rats, Riker Laboratories, Inc.,
Genotoxicity
1) aGenndoCteolxlicPirtoyliTfeersattioonnTA-s5s7a1y1s.1iniRnattheLiIvneVriCveolrllsn, HViatzreoltUonnscWhaesdhuilnegdtoDn,NHAWSyAntShteusidsy No. 15515-0-494, September 14, 1993, and attached protocol
2) WMuatsahgienngitcoint,yHTeWstAoSntTu-d5y7N1o1. i1n5a5n15I-n0V-i4v54o,RAaptriMlic3r0o,n1u9c9l3e,usanAdssaatyt,acHhaezdePlrtootnocol and memorandum containing analytical data
3) TEevsatlu(awtiitohnoIfndtehpeenMduetnatgeRenpiecatA)c,tiNvoitTyooxfPTr-o5j8e7ct4 1i1n5t9h3e2A,mNeosToSxalSmuobnsetlalnac/eMi3c8r1o87s,ome 3M Reference T-5874.1, April 19, 1994
4) PEevrailpuhaetriaolnoHfutmhaenAbLiylmipthyoocfyTt-e5s87(4wittoh IInndduecpeenCdherntomRoepseoamt)e,ANboerTroaxtiPornosjeicntCu1l1t5u9r1e9d, NoTox Substance 38187, 3M Reference T-5874.2, May 5, 1994
5) MEvuatlautaitoinonToefstthweitMhuLt5a1ge7n8iYcMAoctuisveitLyyomfpT-h5o8m7a4Cienlalsn (IwniVtihtIrnodMeapmenmdaelnitaRnepCeealtl),Gene
NoTox 1994
Project
115921,
NoTox
Substance
38187,
3M
Reference
T-5874.3,
April
19,
000036 -18-
Attachments to Letter to C. Auer dated May 18, 2000 Studies and Other Information on Certain
Perfluorooctane Sulfonate-Related`Compounds
Repeated-Dose Toxicity
1) 13-Week Dietary Toxicity Study with N-Methyl Perfluorooctanesulfonamide Ethanol (N-MeFOSE, T-6314) in Rats, Covance Study No. 6329-225, 3M Reference No. T6314.1
a) Audited Draft Report, May 25, 1999
:
b)
Letter
Ph.D.,
from A
Study
ndrew
Directo
M.
r at
Seacat, Ph.D., Study
Covance, regarding
Monitor, to PeteJr.Th
errors in draft report
o
mf
o
rd
,
Mechanistic
1) Analysis of T-5794 in a Cell Proliferation Assay in Rat Liver Cells, Hazelton Washington, Inc., Final Report, HWA Study No. 154-207, January 26, 1994, and protocol and analytical data
2) Analysis of T-5878 in a Cell Proliferation Assay in Rat Liver Cells, Hazelton Washington, Inc., Final Report, HWA Study No. 154-209, November 1, 1994, and protocol and analytical data
000037
AttacShtmuednitess atondLeOtttehrertoICn.foArumeartidoanteodn MCearyta1i8n, 2000 Perfluorooctane Sulfonate-Related Compounds
10. N-EXFOSEA | N-ethylperfluorooctane sulfonamidoethyl acrylate
Acute Toxicity 1) LAacbuotreatOorrayl,TRoixkiecritLyabSocrraeteonriweist,hITnc-.3,4P9r3ojienctAlNboi.no08R8at4sA,R0Sa0f1e0t,y E3vMalRueafteiornence No. T-
3943, February 7, 1984 2) LParbiomraartyorSyk,inRiIkrerirtaLtaiboonrTaetsortiweist,hInTc-.3,4P9r3ojienctANlobi.n0o8R8a4bEbBit0s0,0S9a,fe3tMy ERveafleuraetnicoen No. T-
3943, February 7, 1984 3) LAacbuotreatOocruyl,aRriIkrerirtaLtaiboonrTateosrtiweis,thInTc-.,34P9ro3jeicntANlob.in0o8R8a4bEbBit0s0,0SSa,fe3tMy ERveafleuraetnicoen No. T-
3943, January 24, 1984
Immunotoxicity 1) LGaubionreaatoPriigesMaAxmiemriizcaat,iIonnc.~, PMreotjhecotd,NoS.um4m07a0r3y9,84a,nd3RMaRwefDearteanAcpepNeon.diTx-,36H0a9z,leton
October 5, 1984 (plus May 13, 1985 report amendment)
Genotoxicity
1) MCihtrsoumbiosshoimCahlemAbiecrarlatSiaofnetSytuIndsytoitfutSe,aLmtpd.l,e SDt-u1dyinNCou.lt2uLr1e6d2,Ma3mMmaRleifaernenCeclelsN,o. T6322.3 (FX-13), October 23, 1995
2) aMcurtyalgaetneiicniBtaycTteersitailngReovfe2r-s[eN-Mcutthaytli-oNn-pAesrsfalyuso,roBalMkLy,l (ICn=c1.~S8)tsuudlyfNoon.yl2a8m6i2n,oJ3eMthyl Reference No. T-6322.5 (FX-13), April 24, 1996
3)
SInRIViItnrtoemMaitciroonbailo,loPgriocjaelctMNuot.agLeSnCi-ci3t1y45A,ssSaeypstoefmb3erM,
Company's 1984
Compound
T-3609,
Repeated-Dose Toxicity
1) MTewdeinctayl-ERiegsheta-rDcahyLRaebopreaattoerdieDsoCsoe.,OrLatld.,ToSxtiucdiytyNSot.uBdyMRofI4Sa3mCp,le3DM-1ReifnerReatnsc,eBNioo.T6322 (FX-13), February 16, 1993
000038,
]
AttacShtmuednitess taondLeOtttehrertoICn.foArumeartidoanteodn MCearyta1i8n, 2000 Perfluorooctane Sulfonate-Related Compounds
11. NE" (FOSEMA |Nfeeotnhyalmpiedrofleutohryolomcettahnaecrylate AcuteToxicity 1). lAacbuotreatOorrayl, RTiokxeicriLtayboSrcarteoerniewsi,thIncT.,-3P4r9o4jeicntANlob.in0o88R4atAsR,0S0a1f3e,ty3EMvalRueafteiroennce No, T-
3494 (L-1048, FX-14), March 13, 1984 2) lParbiomraartyorSyk,iRnikIeirtaLtaiboonraTteosrtiewsi,tIhnc.T,-P3r4o9j4ecintANlob.i0no88R4aEbbBi0t0s1,2S,af3eMtyREevfaelrueantcieonNo. T-
3494 (L-1048, FX-14), February 7, 1984 3) lAacbuotreatOocryu,laRrikIeirtaLtaiboornaTteosrtiewsi,tIhncT.-,3P4r9o4jecint ANlob.i0n8o8R4aEbbBiOtOsL,1S,af3etMyREevfaelrueatnicoenNo. T-
3494 (L-1048, FX-14), January 24, 1984 Immunotoxicity 1). 4G0u7i0n3e9a8P5i,g3MMaxiRmeifzearteinocne,NoH.azTl-et3o6n10La(bNorBatNoor.ie6s36A0m1e-r3i2c,a,FXI-nc1.4,)P,roOjcetcotbNeor.9, 1984
Genotoxicity
1). SInRIViItnrtoeMmaitciroonbailo,loPgriocjaelctMNuot.agLeSnCi-ci3t1y45A,ss3aMysRoeffe3rMenCcoemNpoa.nTy-'3s6C1o0m(pNoBuNnod.T6-33660110., 32, FX-14), September, 1984
000039 2
AttacShtmuednitess atondLeOtttherertoICn.foArumeartidoanteodn MCearyta1i8n, 2000 Perfluorooctane Sulfonate-Related Compounds
12. N-MeFOSEA | Nsu-lmfeotnhaymlipdeoreftlhuyolroaoccrytlaantee
Genotoxicity
1). TEevsatlu(awtiitohnoifntdehpeenMduetnatgreenpiecatA),ctNivOiTtyOoXf,T-Pr5o8j6e9ctiNnot.he1A1m59e6s5,S3alMmoRneeflelrae/nMciecNroo.soTm-e 5869.1 (FMZ-3559, Lot 2408, wide-range), April 20, 1994
2) HEvuamlauantiLoynmofpthohceyAtbeisli(twyitohfiTn-d5e8p6e9ndteonItnrdeupceeatC),hrNoOmToOsXo,mePrAobjeercrtaNtioo.ns11i5n9C4u3l,tu3rMed Reference No. T-5869.2 (FMZ-3559, Lot 2408, wide-range), June 5, 1994
3) MEuvatlautaitoinonTeosfttwhietMhuLt5ag1e7n8iYcMAoctuisveitLyoyfmpT-h5o8m6a9Cienlalns (IwniVtihtirnodMeapemnmdaelnitarnepCeeatl)l,Gene wNiOdTe-OrXan,geP)r,ojAepcrtilNo2.0,111959945.4, 3M Reference No. T-5869.3 (FMZ-3559, Lot 2408,
000040 "2.
:
AttacShtmuednitess atondLeOtttehrertoICn.foArumeatridoanteodn MCearyta1i8n, 2000 Perfluorooctane Sulfonate-Related Compounds
13. PFOS
Additional Studies on Perfluorooctane Sulfonate
Acute Toxicity
1)
Acute Toxicity Tests for T-T-6684, perfluorooctanesulfonate:
Didecyldimethylammonium salt of
4) HAaczulteetoOnr,alInTc.oxiPcriotjyecSttNuod.y oCfHT-W66681410i1n1R4a9t,s3(MOERCefDerGeunidceelNion.es)T,-6C6o8r4niJnagnuary 31,1997
b) GPuriidmealriyneDse)r,mCaolmIirnrgitHaatziloe/ntCoonr,rIonsci.o,nPrSotjuedcytoNfo.T-C6H68W4 i6n11R0a1bb1i5t0s,(3OMECReDference JNaon.uTar-y661804,(1d9i9d7ecyldimethylammonium saltofperfluorooctanesulfonate),
) GPuriidmealriyneEsy),eCIrormitiantigonH/azCloertroons,ioInnc.S,tPurdoyjeocftTN-o6.68C4HinWRa6b1b1i0t1s15(1O,E3CMD Reference JNaon.uTar-y662884, (1d9i9d7ecyldimethylammonium saltofperfluorooctanesulfonate),
2) Acute Toxicity Tests for T-5898, lithium perfluorooctane sulfonate, 3M Ref. FC-94:
4)
Final Report, Acute Oral Toxicity Studyof Study No. 40200468, April 22, 1994
T-5898
in
Rats,
Hazelton
Wisconsin,
b) HFianzaelltRoenpoWrits,cPornismina,rySEtuydeyINroit.a4ti0o2n0/0C4o6rr9o,siAopnriSlt7u,dy19o9f4T-5898 in Rabbits,
) HFianzaelltRoenpoWrits,cPornismianr,ySDteurdymaNlo.Ir4r0it2a0t0i4o7n0/C,orMraorsicohn 2S3t,ud1y99o4fT-5898 in Rabbits,
3) (ApceurtfeluOorraolocTtoaxniecsiutlyfoRnaitcsac,idB)i,osMeaarrcchh,4,Inc1.9,736M Reference No. T-1388
Pharmacokinetic Studies 1) RDarbabfittRse,pCorotv,an5c-DeaLialbyoDraotsoeriDees,rmIancl.,ASbtusdyoNor./p6T3to2x9ii-co2i0tn0y,S3tMudRyoefferTe-n6c6e84Noi.n T-6684.
(didecyldimethylammonium saltof perfluorooctanesulfonate, slurry), July 11, 1997
000041 -2-
AttacShtmuednitess atondLeOtttehrertoICn.foArumeartidoanteodn MCearyta1i8n, 2000 Perfluorooctane Sulfonate-Related Compounds
2) 6Qu2a9l3it(ant-icvtehyIlnvFeOstSiEgatpihoonsopfhtahtee dIniaVimtmroonMieutmabsaollti(essmtoerf))T,-T6-2692294(n(-ne-tchtyhlyFlOSE), T-
HpeurmflaunorHoeopcattaonceystuelsfoUnsaimnigdel)onanSdprTa-y6L29C5/M(pSerafnldurLoCoc/tMaSne/MsuSl,foAnadtvea)nbcyedRat and
Bioanalytical Services, Inc., 96ADEMO1.3M, November
[Preliminary] 12, 1996
Analytical
Report,
Report
Teratology
1)
Memorandum Developments
from E. to Date,
G. Lamprecht Nov. 6, 1981
re
Fetal
Rat
Lens
Artifac~t
Summary
of
Analytical
MTeodniScparlayDeLpCar/tMmCenDte,tAedrvmiannacteidonBoifoaPnearlfyltuiocralo SAenravliycteisc,alInSct.,anNdoa.rd9sSPMrYoHviWdOed1.b3yM3,M August 30, 1995
Studies in Progress
1). DPreortiovcaotli,veFsec[eNs-EM(eFtOhSoEd,DPeFvOeSl,opamnednFtOMSeAtJa,bo3lMismStrSattuedgyicfoTroxPiercfolluoogryooLcatbaonreastuolrfyo,nate
Study 1999,
INno-sL,iTfe-6E3n6d.1D7at;eTN-6o2v9e5m.b21e;r
T-7132.3; 24, 1999
ST-41,
In-Life
Start
Date
November
22,
2) (PrNo-tEotcoFlO,SCEe;ll3PMroTl-if6e3r1a6t.i1o1n)S,tPuedryflwuiotrhooNc-tEatnheylSuPlefrofnliucoArcoiocdtPaonteassulsfiounmaSmaildto(EPtFhOaSn;ol R3aMts,T-P6a2t9h5o.l1o6g)y, AasnsdocNi-aEttehsylInPteermaftliuoonraolo,ctSatnuedsyulNof.ona1m1i3d2e-(10P0FOSA 3M T-7091.1) in
000042 x.
Attachments to Letter to C. Auer dated May 18, 2000 Studies and Other Information on Certain
Perfluorooctane Sulfonate-Related`Compounds Bibliography Showing Studies in 3M's Possession Believed To Be In FIFRA Docket.
REDACTED
000043
Attachments to Letter to C. Auer dated May 18, 2000 Bibliography of Published Literature in 3M's Possession
1. POSF - Perfluorooctanesulfonyl fluoride
No literature located.
2. FOSA - Perfluorooctanesulfonamide
Amendale, RF., LT. Stewart, R. Manning, and B. Vitayavirasuk. Determination ofGX-071 and its major metabolite in rat blood by cold on-column injection capillary GC-ECD. Journal of Agricultural and Food Chemistry 37 (1989) 1130-1135.
Cross, T.J., and R-G. Schnellmann. Mechanismoftoxicityof a unique pesticide Nethylperfluorooctane sulfonamide (NEPFOS), and its metabolite perfluorooctane sulfonamide (PFOS) to isolated rabbit renal cortical mitochondria (RCM). Toxicologist 9 (1989) 224. Grossman, MR. Tissue analysisof afluorinatedsulfonamide pesticide: An evaluation of distribution, elimination, andpotentialfor bioaccumulation in orally exposed rats. MS Thesis, University of Georgia, Athens, 1990.
Lofgren, C.S., W.A. Banks, RK. Vander Meer, and DF. Williams. Residual toxicity of some fluoroaliphatic sulfones to the red imported fire ant, Solenopsis invicra (Hymenoptera, Formicidae). Florida Entomologist 72 (1989) 140-146.
Manning, R.O., J.V. Bruckner, M.E. Mispagel, and J.M. Bowen. Metabolism and disposition of Sulfluramid, a unique polyfluorinated insecticide, in the rat. Drug Metabolism andDisposition 19.(1990) 205-211
Schnellmann, R.G., and R.O. Manning. Perfluorooctane sulfonamide: & structurally novel uncoupler ofoxidative phosphorylation. Biochimica et Bicphysica Acta 1016 (1990) 344-348 Vdealnadyeerd-Maecetrio,nRi-nKs.e,ctCi.cSi.deLsoffogrrecno,ntarnoldofDSFo.leWniolplisaimss.iniFilcutoaro(aHlyimpehnatoipctesrual:foFnoer:miAcindaeew).clJaossuronfal of Economic Entomology 78 (1985) 1190-1197. Williams, D.F., C.S. Lofgren, and RK. Vander Meer. The red imported fire ant, Solenopsis invicta: control with fluoroaliphatic sulfone bait toxicants. Journalof Agricultural Entomology 4 (1987) 41-47.
3. PFOSAA -Perfluorooctane sulfonylamido (ethyl) acetate
No literature located.
4. PFDS - Perfluorodecanesulfonate
No literature located.
5. PFHS - Perfluorohexanesulfonate
.
No literature located.
000044
BiAbtltiaocghrmaepnhtysoftoPuLbetltiesrhetdo LCi.tAeruaetrurdeatiend3MM'asyP1o8ss,e2s0s0i0on
6. N-EtFOSA - N-ethyl perfluorooctanesulfonamide Aagpapienls,t AthGe,GearnmdaSnFc.ocAkbrdo-Ealcghh(aDfiacrt.yoTpotxeircai:ty,Blsautbtleleltihdaalc)e.ffeJcotus,rnaanldopfeErcfoonromamnicceoEnftSoumlofllougryam8i3d (1990) 1409-1414. (ADpipcetly,opAt.eGr.a:LaBbloarttaetlolriydaaen)dcofniterlodlp.eJrofuorrmnaanlocefoEfcocnoonmsiumceErnbtaoimtoplroogduyc8t3s (fo1r99G0e)r1m5a3n-1c5o9c.kroach Aitmsemnadjaolre,meRtFab.o,lIitTe.iSntreawtarbtl,ooR.d bMyancnoilndgo,n-acnodlBu.mnViitnajyeacvtiiroansucka.pilDleartyerGmCi-nEatCiDo.n oJfoGuXrn-a0l71ofand Agricultural and Food Chemistry 37 (1989) 1130-1135. Certohsysl,peTr.fJl.u,oarnodocRt-anGe. sSuclhfnoenlalmmiadnen.(NMEePcFhOaSn)i,smaonfdtoitxsimceittayboolfiateupneirqfuleupoersotoicctiadneeNs-ulfonamide (PFO) to isolated rabbit renal cortical mitochondria (RCM). Toxicologist 9 (1989) 224. AFrorgsecnhtlienre, aBnTt.s,,LainndepEivtahnesm,aGhMu.milPee(riMmaeytre)r(tHryemaetnmoenpttesrtar:ateFgoyrumsiicnigdaceo)nt(aaibsnterraiczt)e.d tJo. mEantnoamgoel. Sci. 29 (1994) 264-267. dGurroisnsgmaannd, Maf.tRe.r,prMoilsopnaggeeld,diMe.tEa.r,yaenxdpoBsouwreent,o JaMh.ighDliystfrliubourtiinoanteadndsutlifsosuneameildiemipneasttiiocindei.n rats JournalofAgric. Food Chem. 40 (1992) 2505-2509. dGirsotsrisbmuatnio,n,M.eRl.iminTaitsisoune,aannaldypsoitseontfaiafllfuoorribniaotaecdcusmuullfaotniaomnidienpoersatlicliydee:xpAosneedvraaltsu.atMioSn oThfesis, University ofGeorgia, Athens, 1990. Lfloufogrroeanl,ipCh.aSt.i,cWs.ulAf.onBeasntkos,thReKr.edViamnpdoerrteMdeefirr,e aanntd, SDoFl.enWoiplsliisaimnsv.icRreasi(dHuyamlentooxpitceirtay,ofsome Formicidae). Florida Entomologist 72 (1989) 140-146. MSualnfnliunrgam,iRd.,0a,,unJ.iVq.ueBrpuoclykfnleuro,rMi.naEt.edMiisnpseacgteilc,idae,ndinJt.Mh.e rBato.wDernu.gMMeettaabboolliissmmaanndddiDsipsopsoistiitoinonof 19.(1990) 205-211 NPraobtbeeifne.lAd, tDhJe.sisAnsubInmvietstteidgattoitohnoefGtrhaeduEaftfeecStcshoofoFlloufotrhoechUenmiivceraslistoyonfLiMvienrneFsaotttya,AcAiprdi-lBi1n9d98i.ng aRcetiido,nBi.nLs.e,ctGi.cWid.e,Baegnanientstt, tahnedGSe.Jr.mBaanrccaoyc.krTooapcihca(lDiacntdyooprtaelrtao:xiBcliattytoelfliSdualc)f.luJroaumrinda,l aodfelayedEconomic Entomology 83 (1990) 148-152. (SDcihcatly,oCp.terSau:lfBlluarttaemlildidraecs)i(satbasntcreacatn)d. vJ.apMoerdtiocxailciEtnytionmfoilelodg-yco2l9l(e2ct)e(d1G9e92r)ma2n07c-o2c1k5r.oaches Suncchonueplllemraonfno,xRi.dGa.t,iavendphRo.sOp.hoMraynlnaitinogn..PBeirofclhuiormoioccateatneBiscuplhfyosniacmaidAec:taa 1st0r1u6ct(u1ra9l9l0y)n3o4v4e-l348 eStchhynleplelrmfalnuno,roRo-cGt.aneThseulcfeolnlaulmairdeef)foecntsroabfbiatunreinqauleprpeosxtiimcaildetuSbuullfelsu.raTmoixdic(oNl-ogy in Vitro 4 (1990) 7174.
000045
Attachments to Letter to C. Auer dated May 18, 2000 Bibliographyof Published Literature in 3M's Possession
Smith, LM., cockroaches
Appel, A.G. (Dictyoptera:
Toxicity, repellence, Blattidac) (abstract).
and effectsofstarvation J. Econ. Entomol. 89(2)
compared among (1996) 402-410.
brown
`SSutlufmupr,amDiGd;oNnePmreec-,anMdDP;osHtolnsatoanl,
JF; Piccarillo, Development,
VJ; Mares, Maturation
JT. and
Studyof the Effects of Fertility in the Rabbit.
Toxicology (1997) 357.
SFuo,rmNo-sYa.n, aanndd eRaHs.temSnchseufbftrearhrna.neLaanbtoerramtitoersy.eJvoaulurantailoonfofEtcwonoomsliocw-Eancttoimnogltoogxiyc8an4t(s1a9g9a1i)ns1t70175.
Sagua,iNn.s-tYt.w,oansudbRteHr.raSncehaenfftrearhmni.teTsopxeicciietsyIasnopdtleertahaRlhitniomteeromfiNt-iedateh.ylFpleorrfilduaorEonotcotmaonleosguilsfton7a1mide (1988) 73-78.
Sagua,iNn.s-tYs.u,btTeorkroarnoe,anM.t,eramnidteRsH(I.soSpctheerfafRrhaihnno.tEesrtmiimtaitdianeg) o(rabasltrtaocxti)c.ityJ.oEfcsolnowo-maicctiEnngttoomxoilcaongtys 87 (1994) 398-401
USS. EPA OfficeofPesticides Sulfluramid. Washington, DC
a19n8d9.Toxic
Substances.
Pesticide
fact
sheet
number
205:
United States Air Facility. 5 pages.
Force,
Tyndal
AFB,
Florida.
Environmentally
Acceptable
Live
Fire
Training
dVealnadyeerd-Maecetrio,nRfKl.uo,riCn.aSt.edLotofxgirceann,tsa.nPdeDs.tiFc.idWeilSlciiaemnsc.eC1o7nt(r1o9l8o6f)S4o4l9e-n4o55p.sis invicta with dVealnadyeerd-Maecetiro,nRi-nKs.e,ctCi.cSi.deLsoffogrrecno,ntaronldoDfFS.olWeinlolpisaimss.inFiilcutoaro(aHlyimpehnaotpitcesrual:fonFeosr:miAcindaeew).clJaossuronfal of Economic Entomology 78 (1985) 1190-1197. Winivlilcitaa:msc,onDt.rFo.l, wC.iSt.h Lfloufogrroeanl,ipahnadtiRc Ksu.lfVoanendbeairtMteoexric.anTthse. JroeudrinmaploorftAegdrificruelatnutr,aSloElnentoopmsoilsogy 4 (1987) 41-47.
7. N-MeFOSA -- N-methyl perfluorooctanesulfonamide
No literature located.
8. N-EtFOSE alcohol - N-thyl perfluorooctane sulfonamidoethanol
NPraobtbeeifne.ldA, tDhJe.sisAsnubInmvietstteidgattoitohnoefGtrhaeduEaftfeecStcshoofolFolfuotrhoechUneimviecraslistoyonfLMiivenrneFsaotttay,AcApirdi-lBi1n9d98i.ng 9. N-MFOSE alcohol - N-methyl perfluorooctane sulfonamidoethanol
No literature located.
000046
BiAbtltiaocghrmaepnhtyosftoPuLbetltiesrhetdo LCi.tAeruaetrurdeatined3MM'asyP1o8s,se2s0s0i0on
10. N-EXF--ONS-eEthyAl perfluorooctane sulfonamidoethyl acrylate
No literature located.
11. N-E{FOSEMA - N-ethylperfluorooctane sulfonamidoethyl methacrylate No literature located.
12. N-MeFOSEA ~N-methylperfluorooctane sulfonamidoethyl acrylate
L(aabwstsroanct,).R.JG.,,ChJuerms., PI.nfC..CoClmupsutte.r aScnia.lys3i0s(o1f9a9c0r)yl1a3t7e-s14t4o.guide sampling for toxicity testing L(earwrsaotunm,).R.JG..,ChJuerms., PIn.fC..CoCmlupsutte.r aScnia.ly3si1so(f19a9c1r)yl3a6t1e.s to guide sampling for toxicity testing
13. PFOS - Additional references on Perfluorooctane sulfonate
PFOS
Setchhynleplelrmfalnunor,oRo-cGt.aneThseulcfeolnlaumlairdee)ffoecntsraobbfaiturneinqauleprpeosxtiimcaildetuSbuullfelsu.rTaomxiidc(oNl-ogy in Vitro 4 (1990) 7174,
PFOSH
Dlievrebreml,icM.r,osHoomseoskbaywav,arMi.o,usSpaetrofhl,uoT.rinDaitfefderfeanttcyesaciindst,hemeitnadbuocltiicoanlolfy icnaerrbtodxeyrlievsatteirvaesseofRfLa4ttiyn rat
acids (abstract). Biological & Pharmaceutical Bulletin 19(5) (1996) 765-761.
HPearufglhuoormo,ocBt.a,naoincdAOc.iSdp(yPdeFvOoAl)d,.PTehreflMuoercohoacntainsemSUunldpehrolnyiicnAgctihde (HPypFoOlSiAp)emaincdECflfoefcitbroifc Acid.
Biochim. Biophys. Acta. 11281] (1992) 65-72.
Hwietnhwoliotdh,iuSm Mpe,rflMucoKreoeo-cPteanseiks,ulPf.o,nCaotsetienllroa,bbAi.Ct.s,(aObsstirmaicttz)., TT.eGr.atDoelvogeylo4p9m(e5)nt(a1l99t4ox)i3c9i8t.y study
pCeorstfelluloor,ooAc.tCa.n,eHseunlfwoonoadte, iSn.Mra.b,biOtssim(iatbszt,raTc.tG)..
Developmental toxicity study with Toxicologist 14(1) (1994) 161.
lithium
Hsuartfoa,ctMa.n,tsanindwSahtienrod(aab,stKr.actS)o.luNbiilpiptoynanKdagcraiktiucaZlamsischeil9l1e(c1o)nc(e1n9t7r0a)ti2o7n-s31of fluorinated.
H(pee,rfMl,u,oaronodctFaun,eXs.ulKfionneitciaccsida)ndcaltianleyazrefdreeesteenriefrigcyatrieolna(taibosntsrhaicpt)o.f sWuupleirHacuiadxPuOeSXAu.ebao 6(6)
(1990) 739-742.
Hliovserokmaiwcar,osMo.m,easnbdyT.peSrafltuoohr.iDniaftefderfeantcteysaciindtsh.eXeinndoubcitoiroincoafc2a3rb(o1x9y9l3e)st1e1r2a5-s1e1i3s3o.zymes in rat I4k5e0daa,ndT.,peKr.oxFiuskoudmae,pr1.olMioferria,tiMo.n iEnnroamtoltiove,rTb.yKpoemrfaliu,orainndatTe.dSoucgtaa.neInsduulcpthioonniocfacciydto(PcFhOrSo)m.e P-
000047
:
BiAbtltiaocghrmaepnhtyosftPoubLeltitsehretdo LCi.tAeruaetrurdeatiend3MM'asyP1o8ss,e2s0s0i0on
Peroxisome in 1987, 304-308.
Biology
and
Medicine.
H.D.
Fahimi
and
H.
Sies,
Eds.
Berlin:
Springer-Verlag,
ofKopzeurkoax,isHo.,maYlamfaatdtay,acJ.i,dHooxriidea,tiSo.n,-Wraetlaatneadbee,nzTy,meSsugian,raTt.,liIvkeerdab,yTd.ruCghsa:rraecltaetriiosntsihcisopsfbientdwuecetnion structure and inducing activity (abstract). Biochem. Pharmacol. 41(4) (1991) 617-623. fLoyronch,aPr.aAc.t,erTiozminegr,flKu.oBr.o,alGkranoesssu,lfMo.nLa.tesF.astAnaatlo.mCbhoemm.ba5r7d(m1e4n)t(a19n8d5t)a2n9d8e4m-2m9a8s9.s spectrometry R`aenmaedreo,biAc.c,oanndidtDieonbsus(,abRs.traBcit)o.degCrhaedmaobislpihteyoreff3l2u(o8r)i(n1at9e9d6)su1r5f6a3c-t1a5nt7s4.under aerobic and
sSuolhfloenniicusa-c,idAKis.a,pAotMe.ntEirnidkuscseorno,fCp.erHooxgisstormoaml, Mfa.ttKyiamcliadnBd-,oxJi.dW.atiDeopniearnrde.otPheerrfalcutoirviotoicetsaknenown to be affected by peroxisome proliferators in mouse liver. Pharmacology and Toxicology 72 (1993) 90.
PFOS.Ksalt
BPurbolwinc,HRe.alBt.hTEhnegiTnreeeraitnmge,ntUnainvderDsiistpyoosfalNoefwAqSuouetohusWaFlielsm,FAousrtmrianliga,Fo1a9m8.6. Masters Thesis in tCarveaaltlmie,ntL.,plaAn.t.GeEllnevriar,oannmdenAt.alLaTnodxoinceo.logLyasanrdemCohveamlisatnrdyb1i2od(e1g9r9a3d)at1i7o7n7-i1n7a88w.astewater fCihraenf,igDht.iBn.g,faonadm.E.ESnv.irCohniamne.ntaElcoPnroogmriecssso5fNmoe.m2b,rManaeyt1r9e8a6t,me1n0to4-f1w09a.stewaters containing C5h4-a7n8,-0D6.,B.CivDiilspEonsgailnoeferwiansgteLawbaotreartocroyn,taNianviangl aCqounsetoruusctfiilomn BfaotrtmailnigonfCoeanmte(rA,FPFo)r.t HTueMneNmoe.,MCalif. 93043, April 1978, 19 pgs. Chan, D.B. Disposal of wastewater containing aqueous film forming foam (AFF) - by physicochemical processes. TM No. M-54-79-19, Civil Engineering Laboratory, Naval Construction Battalion Center, Port Hueneme, Calif. 93043, Sept. 1979, 21 pgs. (ChAaFnF,F)D.-BA. Tsoxuic msubomstfapanrcoerg:reDysissptoosdaaltoefownasdteevwealtoeprmecnotntoafianlilngAaFqFuFeoturseaftimlemntfoprrmociensgsefso.amTM N`Hou.eMn-em5e4,-8C0al-if1.0,93C0iv4i3l,EAnuggiunsete,ri1n9g80L,ab6oprgast.ory, Naval Construction Battalion Center, Port fChoiaamn,(AEFSFKF.),wTa.s-tPe.sWfuor,raencdovRerWy.ofiRtowslaacntdi.ve iMnegmrebdrieanntes.trGeeaotrmgeinat oIfnsatiqtuueteouosfTeficlhmnfoolromginygfor US. Navy Civil Engineering Laboratory, Port Hueneme, CA 93043, Oct. 1980, 10 pes. EDnavriwrionn,mRe.ntL:RA.DeEl.iOctattemaBna,laEn.ceC.. NNaotrimoannal,FJi.rEe. PGroottte,catniodnCA.sPs.oHcainataiuosnkaJ.ouFrnoaalm, Maandy/thJeune_ 1995, 67-73. PDliaMnati.oO,peL.raRt.i,onasndPRr.ogFr.eLsasn3ge(.19E8f4f)ec4t2o-f46W.ater Quality on Fire Fighting Foams.
000048
:
BiAbtltiaocghrmaepnhtysoftoPuLbetltiesrhetdo LCi.tAeruaetrurdeatined3MM'asyP1o8s,se2s0s0i0on
RpHryioldjtgeocent,,NaPTt.riDeo.pn,aarlaenLddafbLooFrr.atthWoearlUyk,SeArAu.igrE.nFvo1ir9r8co9en,um5ne5dnetpraglsI.nstteudriaegsenicnysAupgproeretmoefnttheDOliEve 1f4ir8e9t-r1a4i8ni9n-gAlfacbiyliOtiaesk
CJoahrnbsoonn-,114.Din.,raSt.sJ.aGftiebrsaodnm,inainsdtrRa.tE.ionOobfera.mCmhoonleisutmyrpaemrifnleu-oernohoacntacneodatfeecoalr peloitmaisnsaituimon of
perfluorooctanesulfonate. Fundamental and Applied Toxicology 4 (1984) 972-976.
NTKerecowhonpMi,ecaxRli-HcR.oe,,pao8nr7dt11NJ7oE,.. FAMeaFbr.WtLi1-n9.T74RT,r-e79a34ta-pb2gi7sl.9it,AyovAafiiarlqaFubolereocuefsrWoefmialNpmTo-InfSos,roLmraidbneogrrfanotoao.mrsyAD(uD-sEe7Ed5)5f,or3K3if6ri,rtelafingdhtAiFnBg,,
fLoarntdroena-tAmemnotlodf, wSa.,staenwdatDe.Br.coCnhtaani.niAnpgp2lifciarteifoignohtfirnogtaagteinntg(bAiFoFlFog)i,caulndcaontteadcrteopror(tR,B1C7) ppgrso,cess
cLhaenmdoosnt-aAtmaonldd,a r$o.tEa.tiMnigcrboioblioaglictarelactaobnitlaicttyoorf.aPqhu.De.ouDsisfsielrmtaftoironm,inUgnifvoearmsi(tyAoFfEFO)klwaihthomaa,
4N8o1r0m6a,n,80O0k-l5a2.1-10968020.,(OUrndieverrNsoit.y
Microfilms 8302452).
Intemational,
300
N.
Zeeb
Road,
Ann
Arbor,
Mich.
AMucgKuasyt,1J9.8C8.,,
and B. 457-8.
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FOoBrrcieenB,asAe., FM.arTyrleaantdm.enMtaostfeArqsuTehoeussisF,iUlnmivFeorrsmitiyngofFMoaarmyl(aAnFdF,FC)olWlaesgteePwaartke,rMaatrAynldanrde,ws Air
December 1, 1994.
PUSu.aSra.dmu,NeaRIv-nDyd.uC,sotPrm.ipaAll.iWaRaanskctoeewwsCikotinh,fPearnOednTcGWe.,Mp.urneAdtyardteleaedtt,mte.4n0tTrrpegeasqt.uaibrielmietnytos.f fPirreefsiegnhtteidngastcthhoeo3l4wtahstAenwnautaelrs:
RSaelvaizaerw, aSn. dMB.ioTlooxgiicciatlyAosfsAeqssumeeonuts. FNialvmalFoOrcmeianngSFyosatmesmstoCeMnatreir,neSaOnrgDaineigsom,s:CaLliitfeorrantiuar,e
`Technical Document 825, July 1985.
aSnhidnloidqau,idK.m,ixatnudreTs.. NBoamsuicras.tuMdiisecsoibfiliiltyroefpfelluloenrtocaanrdbfoinreaenxdtihnygdurioschianrgbaognenstusr.faJcotuarnntsalinomficelles
Physical Chemistry 84 (1980) 365-369.
SVecnatluelMlio,crRo.coMs.msBi.oDdeepgraardtamteinotnooffBiAoqluoegoyu,sUFniilvmerFsoirtymoifnDgaFyotoanm,CDoamyptoonn,enOtH.inNLoavboermabteorry30,
1986 - November 30, 1987, 34 pages.
PFOS.Li salt
Costello, Sulfonate
HiennRwaobobidt,s"an(dabOsstirmaictt)z,
"Developmental
Toxicity
Study
with
Lithium
Perfluorooctane
000049
BiAbtltiaocghrmaepnhtysoftoPuLbetltiesrhetdo LCi.tAeruaetrurdeatiend3MM'asyP1o8s,se2s0s0i0on
SHEuePlnAfw,oon"aotNde,eiwCnoPRseatstetsli"lcoi(daaebnsFdtarOcastcitS)mhietezt,:"DLeivtehlioupmmPeenctlaulorToooxicctiatnyeSStuuldfyonwaitteh(LLiPtOhSi)u"m (Paebrsftlruaoctr)ooctane
JMVoaiuttrhsinuuakmlio,tef5tCr,oaldNel.coyiI!dkseaudnladf,IantMet.earAnfrdaatlcoietnShoic,uiSme.npcKeearnf1el5us4ohri(on1oa9c,9t2aa)nned45sK4u.-l4fM6oo0nt.atoemuinrath.eSatdusdoyrboendtfhielmmimsciicbeilllisty of
ceSrnhitithincaoaldlpamy,iacK.ne,ldlMeen.ctorKnoocpbeyaonytfarssahotiil,ountaionofdlniNot.fhpiYauarmmaafpgfeuirncfhlciuh.oarionEofccftoeacmntpeosouuflnfidocsne:abteeTr.hge"JoefufofrrencmataltoOifoftnoePmhfpyewraatteurroenonthsehe
Chemistr9y1 (1987) 5292-5294.
sieal
pFbeearhmfaolvruiioo,rroKaonc.dtadKny.ensKauimlhifacornapa,rtoHe.p/edrSitaeinetdshaa,innoKml.ihxEespeutdmasdiye,scKta.efmlMsueoogrfuoar-n2oi-,ounCni.dceTcahanundnoilcgma,etitaonndicHs.urHfoafcftiannatnsn..tPhhiaos.e
S(cDieEnFceU2M7A0Q(1a9n9d2)li8t8h3i-um89d3o.decyl sulfate/DEFUMAC aqueous mixtureh.ylCammooniluamnledhPoioorliiydmeder
000050
Attachments to Letter to C. Auer dated May18, 2000 Studies and Other Information on Certain
Perfluorooctane Sulfonate-Related Compounds
[1-70SF| pertuorooctanceutfonytnuoride
Acute Toxicity
1) Primary Skin Irritation Test with T-3874 in Albino Rabbits, Pathology and
Toxicology,
3874, April
1R4i,ke1r98L6aboratories,
Project
No.
0386EB0135, 3M Reference No.
T-
2) T52-73,6037MARceufteereInnhcaelaNtoi.onTT-o3x6i0c7i,tyDeTcesetm,bBeursh19y,R1u9n84Research Center, Project No. 47-
Genotoxicity 3) Acute Oral Toxicity Study -- Method, Summary, Pathology and Raw DataAppendix, Hazleton Laboratories America, Inc., Project No. 40703983, October 5, 1984
1) 2In54V1itCrooCM,icSrRobIiIonltoegrincaatlionAasls,ayPrsojoefc3t MNo.CoLmSpCan4y44C2-o1m6p,o3unMdsReTf-e2re5n4c0eCNoo.C Ta-n2d5T41-.1
(FC-3452), August, 1979
Ongoing Research/Study Protocols 1) LPraobtoorcaotlo,ryP,ha3rMmaRceofkeirneentciec SNot.udTy-o70f9P8O.S1F in Rats, 3M StrategicToxicology
Pre-1976 Studies (bibliography only) 1) 5S0k9i1n2I4r1ri,ta3tiMonRaenfderEeyneceIrNroi.tatTi-o1n3S2t9u,dySeRpetpeormtb,erW9A, R1F975Institute, Inc., Project No. 2) Acute Vapor Inhalation Toxicity Study in Rats, Industrial Bio-TestLaboratories,
Project No. 663-07513, 3M Reference No. T-1329, October 23, 1975
000051.