Document Nor11ovMnE2JR64ngb8jBGe8

wt a SLanadmMVyiceR.ecPZoobsDetrleoMnrD ME 5M Medical Department 8MP1l7aG5el3neNS:1N8B1u$iO5d1fi6nf8g1(020200.06:%08 661733 S152 Fax 3M June 27,200 : Sue Shallal, Ph.D. Designated Federal Officer U.S. EPA Science Advisory Board Via -mail: shallal.suhair@epa.gov :: . Re: PFSOuAbmRisesviioenwoPfaPnaeltholo* gy Working Group Report ; on Mammary Tumors in Chronic StudyofPFOA Dear Dr. Shallal: ` : 5 0; # `We are submitting for the PFOA Panel's consideration a copy oaf recently-completed ; i `Pathology Working Group (PWG) report examining the mafnmary findings from the 3M (Sibinski et al. 1983) chronic study on PFOA. (Experimental Pathology Laboratories, Inc., "CPhartohnoilcoFgeyePdeienrgRSetvuidyewinaRnadtPsawtihtohloPgFyOwAo,r"kiJnugneGr1o7u,p20R0e5v.i)ewoThfeMpaatmhmoalorgyy Grleavnidesw wfarosmaa joint projectofthe 3M Medical Department and DuPont Haskell Laboratory. "The report concludes (p! 12): ! The PWG concluded that the incidence ofmammary gland `neoplasms in the study was not affected by chronic dietary `administration of PFOA. The morphologic appearance, overall ianncdicdoenntcreolanadnidmiasltrsiwbuetrieonosifmitlhaer.neoplasms observed in treated ' `The chronic study included acontrol group and two dose groups which received 30 or 300 ppm in the diet. The slides were retained, and were made available to the reviewing pathologist, Dr. Gabrielle Willson. Dr. Willson reexamined all sections of manimary gland from all female rats in all dose groups. Dr. Jerry Hardisty of Experiental Pathology Laboratories then convened a Pathology Working Group including Dr. Willson, Dr. Ray Blersoiownns adnidagDnro.seEdmebsyctitMhceCrotnhneelorligtiondaletsetrumdiynepaathcoolnosgeisntsuosr dtihaegrneovsiisewfionrgalplatnheoolpolgaisstticand to determine the toxicologic significanceofthe incidence of mammary gland neoplasms present in the female rats in the PFOA study. The Pathology Working Group examined the slides `without knowledge of the treatment groupof the animals, and applied diagnostic criteria and nomenclature ofthe Society ofToxicological Pathologists (Mann et al. 1996). | "JDru.neSu2h7a,i2r0S0h5ellal ! Page20f2 "The primary difference between the original reported findings and the PWG results involved g f"Tihnedriengwseirneitimailnloyrredpiofrfteerdenacsesloibnucllaarshsiyfpiecraptliaosnoiafwothhiecrh ftihnediPngWs.G Dcrl.asDsiafviieddaGsafyilborroadenoma. performed statistical analyses on the findingsforthePWG. The PWGreportsates: : + _ Tfhiberroeadweenroemnao, satdaetinsotciacarlcliynsoimgani,tfoitcaanltbedinfifgenrennceeosplinasthmes incidence of or total malignant `pnaeiorpwliassemcsobmeptawreiesnoncontrol and treated animals using Fisher's Exact Test for : Combining benign andmalignantneoplasms is not recommended. However, even if ctroemabtiednegdrouipnst.his(ps.tu1d1y), there was no'significant difference between cquirdl and 2 4 + Ndiognniefoifcatnhtesutruvmiovarlt-yapdejsusotredcodmobsien-aretsipoonnsosfetturemndosr. t(py.pe2s0)exhibited statistically : Thanedrtreeawtaesdngrooiunpcsr.eas(pe. in1t1)umor multipolriinccidietncye with dosebetween control Tohbesermvoerdphionltohgeicconatprpoelargarnocupeo, finndiecoaptliangsmtshiantttrreeaattemdengtfdoiudpsnowtaasffsecitmtihletaporhethnoosteype ofthe neoplasms in the study. (p. 11) . The incidenceofmammary gland control data for untreated Crl:CD neoplasms in the study is similraro isrical female Sprague Dawley rats in 104-week studies, as reported in the literature. (pp. 11-12) : Respectfully submijted, 7 bel, M.D, MPH. StaffVice President and Medical Director Ecen:clEosPuAreAR-226 Docket Dr. Jennifer Seed Dr. Robert Rickard EPL EXPERIMENTAL PATHOLOGY LABORATORIES, INC. Report Title PATPHAOTLHOOGLYOWGOYRPKEIENRGRGERVOIUEPW ARNEVDIEW FROMOAFCMHARMONMIACRYFEGELDAINNDGSSTUDY IN RATS WITH PFOA PWG REPORT ' . DataRNeqAuirement ` " Jerry F. HAaurtdihsotry, DVM. JuneD1a7t,e2008 Y ExperimePnetrafloPramtihnogloLgayboLraabtoroartyories, Inc. Research PT.rOi.anBgloexP1a2r7k,66NC 27708 DuPont HasSkpeollnsLoarboratory for \ Health and Environmental Sciences 1090 Elkton Road NewaPr.Ok., BDoEx 5109714 | EPL PProrjoejcetcNto.ID126-060 VOLUME 1 OF 1 PAGE 10F 74 EPL| EXPERIMENTAL PATHOLOGY LABORATORIES, INC. 4 " PATPHAOTLHOOGLYOWGOYRPKEIENRGREGVRIOUEPW ARNEVDIEW FROM OAFCMHARMONMIACRYFEGELDIANNGD,SSTUDY INRATS WITH PFOA CERTIFICATION OF GOOD LABORATORY PRACTICES ' "LTarbiosrPaattohroylPorgayctWiocrekiSntganGdraorudsp (R4e0vCiFeRw,(PPaWrGt)16d0o)esdonontotcoanpsptliytuotetahissturedpyo.rtT.heHroewfeorvee,r,Goaold appropriate documentation of the review process has been maintained. Signature: ; Author Hardly = 200 & 2 EPL EXPERIMENTAL PATHOLOGY . LABORATORIES, INC. , PWG PARTICIPANTS: Co ' oDiplihFna.te JAaCVrPos. DV. vn (Chairperson) ` FGARBCR.IEPLatLhE A. WILSON, BVMS, WRGVS (Reviewing Pathologist) DWiRplAomYatse aACiYnP. DVM. PhD. 7 (Consulting Pathologist) Fads me LoL DEiRpNloEmSaTteE.ACMVCPC,OANBNTELL, BVM, MS. (Consulting Pathologist) | + : } \ 3 EPL EXPERIMENTAL PATHOLOGY LABORATORIES, INC. : . PATPHAOTLHOOGLYOWGOYRPKEIENRGRGERVOIUEPWARNEDVIEW FROM OAFCMHARMONMIACRYFEGEDLIANNGD,SSTUDY . IN RATS WITH PFOA TABLE OF CONTENTS `. TITLE PAGE . CERTIFICATION OF GOOD LABORATORY PRACTICES PWG PARTICIPANTS' PAGE TABLE OF CONTENTS NARRATIVE APPPWEGNDCoInXsAensus Diagnoses for Individual Animals Reviewed in Each Group . APStPatEiNstDicIaXl ABnalyses of Mammary Tumors in Rats Fed PFOA | ACPuPrEriNcDuIluXmCVitae wae! Page hd th 3 4 5 os) 19 . 21 4 EPL : EXPERIMENTAL PATHOLOGY LABORATORIES, INC. " " PATPHAOTLHOOGLYOWGOYRPKEIENRGRGERVOIEUWPARNEDVIEW FROMOAFCMHARMOMNIACRYFEGELDAINNDGSSTUDY IN RATS WITH PFOA EPL PROJECT NO. 126-060 NARRATIVE SUMMARY INTRODUCTION Hematoxylin and eosin stained and trichrome stained microscopic sides of r mammary gland from female rats used in a chronic feeding study in rats with PFOA were received from DuPont Haskell Laboratory for Health and Environmental Sciences, Newark, Delaware by Experimental Pathology Laboratories, nc. (EPL), Research Triangle Park, North Carolina. The study was conducted by the 3M Corporation and the tissues from the study had previously been examined and the resuls reported by Dr. Robert Gel, the Study Pathologist (SP), for the 3M Corporation. A summary of the group design according to the protocol for the study is summarized in Table 1 below: . Table 1. iEnxFpeermiamleentSaplraDegsuieg-nDafwolreayCRhartosnwicthFeePdFiOngAStudy eDsitetMaartyerLieavle(l popf ) Number of Female Rats ) ET sIanctreirfiimce TSeacrrmiifniacle 1% Or. Gabriele Willson, the Reviewing Pathologist, reexamined all sections of mammary gland from al female rats in all groups, al previously reported mammary neoplasms and si previously reported subcutaneous neoplasms. Prir to the reexamination ofthe sides, the necropsy records were compared tothe reported microscopic findings to ensure tha ll grossly described mammary and subcutaneous masses were sectioned and s EPL EXPERIMENTAL PATHOLOGY LABORATORIES, INC. T . examined microscopically. The purposeofthe peer review was to validate the accuracy and consistency of the initial histopathologic examination andto identify the issues that needed to be addressed during the review. The preliminary review of the data indicated that all masses were sectioned and examined microscopically Following the reexamination of the histopathology findings of ll sections of the. mammary gland by the Reviewing Pathologist, a Pathology Working Group (PWG) was convened for the purpose of providing a consensus diagricsis for all neoplastic lesions involving the mammary gland which were diagnosed eitbhyethre Study Pathologistorthe Reviewing Pathologist. The PWG members consistedofthe Reviewing Pathafogist, Or. Willson, and the two consultant board-certified veterinary pathologists with extensive = . experience in the microscopic evaluation and interpretation of lesions observed in chronic toxicity and oncogeniciy bioassay studies conducted in rodents. The original Study Pathologist was not available for the PWG meeting. The PWG's task was to provide a consensus diagnosis for each of the mammary gland neoplasms reported by eitherthe Study or Reviewing Pathologist and to determine the toxicologic significance of the incidence of mammary gland neoplasms present inthe female rats treated with PFOA in the diet. `Conduct of the Reviewing Pathologists Examination " `The mammary gland and all subcutaneous masses were evaluatedfofhistopathologic changes during the Reviewing Pathologists examination conducted by Dr. Willson. Although all microscopic findings in the mammary gland were reviewed, particular emphasis was given to neoplastic lesions. All slides containing sections of mammary tissue with a primary neoplasm of the mammary gland diagnosed by either the Study or ReviewingPathologistwere organized for the PWG review. 6 EPL : EXPERIMENTAL PATHOLOGY LABORATORIES, INC. ' `Conduct ofthe Pathology Working Group Review The Pathology Working Group was chaired by Dr. Jerry F. Hardisty, Experimental Pathology Laboratories; Inc. (EPL), who organized and presented the material to the panel of three pathologists. Curicula vitae fo the PWG Chairperson and eachof the PWG participants are present in Appendix C. The PWG review was performed on May 18, 2005, at Experimental Pathology Laboratories in the Research Triangle Park, North Carolina, Individuals attending or participating in the PWG review are listed below: ODri.pJleormrayteF,. HAa.rCd.iVs.tPy., (PWG Chairman) DFr.RCGabPraitehlle Willson, (Reviewing Pathologist) : EE, : Dr. W. Ray Brown (PWG Participant) \ DDr.ipEloEmatMec,CAo.nCnVe.lP. (PWG Participant) v : Diplomate, AC.V.P. g ODri.pSltomeavteen,RA.CFVrPame Mr. Gerald Kennedy (Observer) (Observer) The PWG examined coded siides without knowledgeoftreatment group. Each participant recorded his/her diagnoses and comments on worksheets which were prepared by the. PWG Chairperson. The PWG examined the mammary gland only for neoplastic lesions and did not consider ather lesions which may have also been present. Each lesion was discussed by the group, reexamined if necessary, and the final opinions were recorded on the Chairpersons worksheets. The consensus diagnoses of the PWG were reached when atleast two of the three PWG participants were in agreement. During the PWG feview, the nomenclature and diagnostic criteria recommended by the Society of Toxicological Pathologists was used by the PWG to classify the profferative lesions (Mann, et.al, 1996). A summary of the diagnostic criteria and nomenclature used by the PWG participants for proliferative lesions of the mammary gland of rats is presented below: 7 EPL EXPERIMENTAL PATHOLOGY LABORATORIES, INC. ? Nomenclature and Diagnostic Criteria for Proliferative Lesions of the Mammary Gland in Rats LOBULAR HYPERPLASIA Dilatationof ducts or ductus usually present Evidence of epithelial or glandular proliferation. ih | May contain mild celluar pleomorphism and mitotic activity FIBROADENOMA Composed of glandular epithelium and fibrous connective tissue. si Epithelium is generally single ayered and uniform and may contain lipid vacuoles. ! Corhective tissue distributed within and between lobules ranges from welkdifierentiated to dense hyalinized collagen with few interspersed fibrocytes Epithelium often forms ductules, alveoli or small cysts. 7 Focal areas of alypia andlor cellular pleomorphism may be present. Mast cells may be frequent. ! ADENOMA ) Discrete nonencapsulated mass consistsofproliferating alveolar structures in clusters separated by scanty connective tissue septa. \ Alveoli have a single layer of low cuboidal to columnar epithelium with small nuclei and a single nucleolus; epithelium often vacuolated. \ Alveolar lumina may be empty or filed with minimal secretion (tubular patter) or may be. widely distended by proteinaceous secretion (secretory pattern). * Luminal surface of epithelium generally round, may be smooth or serrated. Focal areas of atypia and/or pleomorphism may be present. Papillary projections of epithelium may occur, either protruding into diated ductal lumina (papillary pattern) or into cystic spaces which may be simple or multioculated (cystic papilary pattern). ADENOCARCINOMA * May be noninvasive or invasive. 8 EPL : - EXPERIMENTAL PATHOLOGY LABORATORIES, INC. B May have distant metastases. : v Neoplastic epithelial cels from 1-4 or more layers thick. Uniform epithelial cels basophilic to eosinophilic with round to oval centrally located nuclei. Chromatin clumped, single small nucleolus. Numerous mitotic figures, * Multiple branching papillae covered by cuboidal to columnar epithelium (papilary pattern) C(tluobsuellayr ppaatctkeernd),. generally empty, tubular structures which may be rqund or elongated Neoplastic epithelial proliferation in a solid sheet with the formation of secondary lumina (cribriform patter). . : Distended ductus lined by a tumor cells (comedo pattern). multilayered epithelium surrounding a central coreof necrotic : + : . ADENOCARCINOMA ARISING IN FIBROADENOMA 4 Adenocarcinomatous change within a fibroadenoma. Histologic patter of fibroadenoma component variable. , Typical histologic appearance of adenocarcinoma present. After the PWG completed the siide review and the diagnoses were recorded by the PWG Chairperson, the slides were decoded diagnoses for individual animals reviewed in by treatment group. PWG consensus. each group are presented in AppndiAx. A summary of the incidence of neoplasms in the mammary gland of female rats is tabulated in Table 2. ! s EPL EXPERIMENTAL PATHOLOGY LABORATORIES, INC. at Table 2. ChrIonnciicdeFneceediofngMaStmumdayriyn FGleamnadleNeSoppralgausem-sDianwlFeeymaRlaetsRawtitsh PFOA: [Tee [ene]s sr low] Nevopind alae an| 62% -- lls] : Faroadenoma, Mail (4 Be L FE1N2% : EC FAFAA E . RE aE saL[ee 5onALDoRyT ) [ootpnmaiswinpengnrumors | 15|10| | 22| 21 |2| [oTEoaEtaoErmo aswiT ttgna aTntomRers|R&R |E 0S|R1R|R 16a|a a5 |ae 5|| NNo.iogfrAaniTmeanlowristh Boh Beign and [=] 3 Ee a aE pomar-- Lelelee (Benign or Malignant)* , *Some affected had more than one tumor type. ** Two Group 5female rats had fibroadenoma present in the interim sacrifice group. ISCUSSION AND CONCLUSION The results of the PWG Review generally supported the Reviewing Pathologists findings. The primary difference between the original reported findings and the PWG results involved changes in the mammary gland that were initially reported 2s lobular hyperplasia by the Study Pathologist which the PWG felt had features more characteristic of mammary gland fibroadenoma. This difference involved six Group 1, two Group 6 and two Group 5 female rats. Although there were a few differences concerning the classification of benign 10 EPL " EXPERIMENTAL PATHOLOGY LABORATORIES, INC. 5 . P`aantdhomlaolgiigstnawnetrneegcpolnafsimrmse,dtdhuermianjgotrihteyPofWtGhereotvhieerwnoefompalmamsmasryregploarntdednbeyoptlheasSmtsudiyn female. rats from this study. , Although the incidenceofneoplasmsvariedamong the control and treated groups, there were no statstcally-signfcant ferences when evaluated using the Fisher's Exact Test for pairwise comparison for fibroadenoma, adenocarcinoma, total benign neoplasshs or total malignant neoplasms. benign and malignant neop The PWG noted that although lasms be combined since there it is not was no recommended that histologic evidence of tumor progression from benign to malignant (McConnel, 1986). However, evenifcombined in this study, there was no significant diference between control and treated groups. The a only statistically significant difierence (<0.01) involved a negative pairwise comparison in the incidence of adenocarcinoma in Group 6 (30 ppm) compared to Group 5 (300 ppm). . : + Statistical analyses of mammary tumors inratfedPFOA conducted by Dr. David W. Gaylor are presented in Appendix B There was no increase in tumor multiplet or incidence with dose between control and treated groups. The morphologic appearance of the neoplasms present in treated groups was similar to those observed in the control groups inditating that treatmeindt not affect the phenotype of the neoplasms in the study. The incidence of mammary gland neoplasms observed in this study is similar to historical control data for mamrhary gland neoplasms in unireated CriCD female Sprague-Dawley Rats in 104 week studies in the open literature (Inveresk Research, 2002; Giknis and Cliford, 2001; Giknis and Gifford, 2004; Chandra, et al, 1982; McMartin, ot a, 1652; Stevens, etal, 1994; and Sykes G, : 1887) presented in Table 3. Table'3. SHpisrtaogriucea-lDCaowniteroylRDaattsaInIn1U0n4lrWeeaetekdSCtrud:iCeDs Female + | somows | riroroenow Rererence Comrie| soos | oooses | eswomn mesmo |1 84% (17:320%) | 411% (133:612%) | 207% (868.3%) 0% (11320%) | 381% (133623%) | 202% (8658.3%) _i|GnitlsetMOLBA. asnadt _|Giford CB, 3008 1" EPL EXPERIMENTAL PATHOLOGY LABORATORIES, INC. & ADENOMA ' FIBROADENOMA |ADENOCARCINOM| A reece | asa (un) 18.96% Ow- aso- wy C|rhoeapnda, era, 5% @e-11a%) | 313% 200-433% | 168% 67-30%) | V10a8r2 in ON, efal, 1% ) 53% 364 17% (319) | S1t95e4v.enAsr,eIzTinleal, 5% (015 278 1% (025) . | S1t9e0v4e.nPs,roJTp,aenreal, 2% (3-11) 30% (20-43) 23% (11.67) 18% (7-30, o% (318 Stevens, JT, etal, S11t6996e44v,,enSTsiemrJahTzi,ihenyteaasli.ne . Sykes, 1087. US : . 1.9% :(0-0.1%) 37.4% (24.2-54.0%) ERePcAorAddm2i2ni6s.t1r9a1t7ive "NA = Not available . CONCLUSION The PWG concluded that the incidence of mammary gland neoplasms in thisstudy was not affected by chronic dietary administration of PFOA. The morphologic appearance, overall incidence were simiar. and distribution of the neoplasms observed in treated and " . controlgroups JERRY F\HARDISTY, DV. Diplomate, ACVP Chairperson IT eos Dat 2 EPL ; EXPERIMENTAL PATHOLOGY LABORATORIES, INC. . REFERENCES ' Chandra M, Dawiey rats. RAirlceyh MToCxIicaoln,d 6J6:on49s6o-n502D.E (1992) Spontane,ous neoplasms in aged Sprague- Giknis MLA and Clifford CB (2001) Compilation of spontaneous neoplastic lsions and survival in Cri:CD (SD) BR rats from control groups. Charles River Laboratories. Giknis MLA and Clifiord `survival in Crl:CD (SD) CB rats (2004) Compilation of spontaneous from control groups. Charles River Lnaebooprlaatsotriicesl.esions and Inveresk Research (2002) Background Tumour Incidences CD Sprague-Dawley rhs. lMeasnionnsPoCf,tBheoomrammamnaGrAy, gLloalinndi iLnOr,atsM,cM1a5-r2t.iInnDGNuiadneds GfooroTdoxmiaconloDgGic(P1a9t9h6o)loPgryo.liferative Pl STP/ARP/AFIP, Washington, D.C. "combMicCnoinnnelgl nEeEo,pSloalslmesveflodrHeAva,luSawteinobneorfgroJdAenatncdarBcoionromgaennesGiAs s(t1u9d8i6e)s.GuNidCelLinVeosl.fo7r6, No. 2., 283-269. rMeclMaatretdipnroDlNif,erSataihvoetlaesPiSo,nsGiunncsoontnroDlES,pHrsauguHe-HDaanwldeSypraaetts fRrHom(1c9a9r2ci)nNogeeonpilciatsymsstuadnieds. Historical 212.225. data and diagnostic . considerations. Toxicologic Pathology, Vol. 20, Number 2, fSotremveanmsmJaTr,yBrteucmkoernirgiedngeesiCsBi,n WSeptrzaeglueL-TD,aGwillelsyJRHatasnedxLpuoesmepdertotceIrlltLaiGn(t1ri9a8z4i)neHyhpeorbtihcisdiess. Jurnalof Toxicology and Environmental Health, 43:138-153. > Sykes G US EPA A(d1m9i8n7i)stTrwaot-ivyeeaRrecTooxridci2t2y6/-C1a9rc1i7n.og1e-n6i.city Sudy of Fiuorochemical ' FC-143 in Rats. . . . 13 EPL EXPERIMENTAL PATHOLOGY LABORATORIES, INC. . APPENDIX A ' : PWG ConsenRseuvsieDwieadgnionsEeascfhorGrInoduipv.idual Animals . 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FEAERCE ERC ER E.|| 2| oof RAN ARE Blefeietaeal aeeitonnarnnafuannss <3|2/8/2/812/8 21228 |2 gee sleleleglg 2ggs g 28g E FE RIEERE EEE EEREEE 2 EE El EEE AR A AAA cl 2 2 . 4. | foe Tle! 2523 2[38 S d EoaegI5E9 EESRHB 5 Ll 08 8) |] = 2/8EeliE E poennneBiiEaen2solf 2reelre eol2ze |ao|afanl[ lt88eeleelsnlole = FE Si BORRE HEHE E Ree 313 Il lg iy 1 3) ry : Sisle5feglfeele:af2 "EERE Ress aeafi,taessr2ee 2f.unnies reese: E Boil E FraE imiee =7 27239e%esee (928832 sTlyeyss lReEkRlyzEsdtEgEsscieeEsElaenlys Bi 0d EEE einige: TTT . LE ic $3, o| El &| [H#EeEgR8EiRsEsgEREiEf "BBEeE, FEE sl85l55lgg esl f | g [Beeesgss & gl Heigl = $55HeleenlHlJo gE] E e22 E 2 SE E 82 1me : | Hilt EPL , EXPERIMENTAL PATHOLOGY LABORATORIES, INC. v APPENDIX B ' Statistical Analyses of Mammary Tumors in Rts Fed PFOA ve Te 18 612/05 : 4 Statistical Analyses of Mammary Tumors in Rats Fed PFOA | GayDlaovri.danWd.AsGsaoyclioart,esP,h.LDL.C Introduction Female Sprague-Dawley rats were fed PFOA in a chronic bioassay. The incidence of `animals with mammary tumors reported by the Pathology Working Group are listed in Table 1. The denominators are the effective numberofanimals at risk (adjusted for survival) as calculated by the National Toxicology Program Poly-3 procedure (Portier . `and Baler, 1989). 1 . Table 1. Incidence of mammary tumors in female ratsfed PFOA. ii Tumontype 0 ppm 30 ppm 300 ppm. : sheet --s -- ie Adenocarcinoma 9/404 16/434 sia Fibroadenoma 18/414 2/411 23/443 Adenoma 1/384 0/385 0/414 Fibrosdenoma/Adenoma~~ 19/417 22/411 23/443 Adenocarcinoma/ : Fibroadenoma/Adenoma, 24/429 31/447 25/453 Results : sNtoatniesotifcatlhley stiugmniofrictaynptessuorrvicvoamlbaidnjautsitoendsdoofset-urmeosrpotnyspeestrleinsdtse.d iNnoTasbtlateis1tiecxatlilybistiegdnificant survival adjusted peir-wise increases in tumor incidence compared tocontrolswere noted. All P-values exceeded 0.10. References Portier, CJ and Baler, Al. Testing for increased carcinogenicity using a survival-adjusted quantal response test. Fundamental Appl. Toxicol. 12: 731-737 (1989). 20 EPL EXPERIMENTAL PATHOLOGY LABORATORIES, INC. T APPENDIX C yor t * Curicula Vitae 21  EPL coer nt ' JERRY F. HARDISTY PRESIDENTIVETERINARY PATHOLOGIST EDUCATIIowOaN:State University, Pre-Veterinary, 1965-1967 Iowa State University, DVM. 1971 Certified by the American College of Veterinary Pathologisis, 1976 Adjunct NC SAtsastoeciUnaitveerPsriotfy,es1s9or83at the School ofVeterinary Medicine, oo 4 J P19R9E8S-EPNreTsePnOtS.ITIPOrNesAidNeDntEaXnPdEPRatIhEoNloCgEis:t, Experimental Pathology Laboratories, ACE :: Inc. Research Triangle Park, North Carolina . lRaebsoproantsoriibelseifnoVriorvgeirnailalamnadnNaogretmheCnartolainnda.diTrehceticonomofpaconnytrsaecrtvreesseboatrhchgopavtehronlmoegnyt and university research and the safety assessment programsof the pharmaceutical, chemical, and cosmetic industries. 1994-1098. Vice President, Operations and Pathologist, Experimental Laboratories, Inc., Research Triangle Park, North Carolina Responsible for overall management and direction of pathology research . Iaboratories in North Carolina and Virginia. 1978-1994. DInicr,ectRoerseaanrdcPhatThroilaonggilset,PaErxkp,erNiomretnhtCaalroPlaitnhaology Laboratories, NRoerstphonCsairbolleinfaobtrhaencphroojfecEtPmL.anaRgesepmoennsti,bldeirfeocrtitohneamnidcrtoescchonpiicaclesvuapleuravtiiosnioonfof the ' toxicological studies. Responsible for the National Toxicology Program's Pathology Quality Assessment Program and Operations of the NTP Archives. 4 1676-1978. PLaabtohroaltoogriisetsP,roInjce.c,tHMearnnadgoenr,,ViErxgpienriaimentalPathology Responsible or the management of EPL's Carcinogenesis Support Laboratory. Project Manager ofa program to provide Tracor Jitco with Qualty Assurance in the NCI Carcinogenesis Testing Program. Technical supervision of a program to provide pathology support services to the Carcinogenesis Program of the National Cancer Institute. Responsible for the microscopic evaluation of tissues from experimental animals used in a variety of toxicological studies. 22  Experimental Pathology Laboratories, Inc ' JERRY F. HARDISTY, D.V.M. ~ Continued : : PRESENT 1972-1876 POSITION AND Research EXPERIENCE - Continued Pathologist, Veterinary Pathology Branch, . Biomedical . Laboratory, Edgewood Arsenal, Maryland DPra.thHoalrodgiys.tyDwuarsinag pthriescteipmteeeheinptehrefoU.rSm.edArgmroysspraencdepmtiocrrsohsicpoppriocgdriaamgninosVeetseorfinary : Isapboonrtaatonreyouansimdailsse.aseHeanpdrecphaarnegdersepporrotdsudceesdcrbiybienxgpearnidmeinnttaerlprpertoicnegdtuhreessein experimental results. a Dteurraitnoggetnhiisctsitmuedhiees wpaesrfoprrimnecdipaalt tihnevelsatbiograattoorrfyo.r tThheisrweoprrokduccotnivsei,stmeudotafgreenviics,ing we putriefviizeodusafetxhpeerliambeornattaolryp.rotTohceolesxpaenrdidmeenstiaglnidnegsingenweemxppleoriymeedntraelqupirroetdotchoelsgtroosbse ! . 3 etexraamtiongaetnieosniso.f pHreegtnraainntefdebmiaolloegircaatls taencdhnfiectiuasnesstfoorpeervfiodremncteiomfedetmaaltitnoxgisciitny raantsd, . efoxrapmriennaetaselriaablnloyrsmeaclttiioense.d fetuses for malformations, and to examine fetal skeletons 1971-1972 AWtatteendriRngeeVdeteArrimnayriIannst,itDuitveisoifoRneosfeBairocShensor Research, mDru.scHualrodsiksetlyesttauldideidsetahseersaodfiotghreapGheircmaannd SmhoerpphhoelrodgiDcogl.esiIonnassosfocsieavteiroanlwith Dr. WcaanyinneehRiipsedry,sphleasiinav,esetoisgiantoepdhitlhiec ppaantohsotgeeintiessiasnadnudnupnoistsiebdlaengceonneetailc rperloactieostsisehsipinofan attempt to reduce their incidence through a selective breeding program. PRODFipElSoSmaItOe,NAALmeMriEcMaBnECRoSlHleIgPeoSf:Veterinary Pathologists A`ACmVerPicSaunbsCpoelclieagletyofiTnoTxoixciocloolgoygic Pathology Society of Toxicology Society of Toxicologic Pathologists BIrnitteirsnhatSioocniaeltAycoafdTeoxmiycoolfoTgoixciPcaotlhoogliocgPisattshology American Veterinary Medical Association CNohratrhleCsarLooluinsaDSaovciise,tyD.oVf.MT.oxiFcooulnodgaytion The Society of Phi Zeta TThhee SFroactieertnyitoyfoGfaAlmpmhaa ZSeitgama Delta The Fraternity of Omega American Association for Tau the Sigma Advancement of Science x : 23  -- rmmmmssrA iemsmeeeeeeeemeestmir. 4 . JERRY F. HARDISTY, D.V.M. - Continued ! PROFE"SSStaInOdNarAdLizAedCTSIyVsItTeImESo:f Nomenclature and Diagnostic Criteria (SSNDC), The. Exec`uSotciiveetyCoofmmTiotxticeoel,ogTihcePSaothcoileotgyisotfsT,ox1i9c8o7l-o1g6i9c5.Pathologists, 1894- 1998. Executive Committee 1997-1996, Chairman, The Society of Toxicologic Patholog: ists, JointNoCmoemnmciltatteuerefoarnSdTPDSi/aIgLnSoIstoinc CIrnitteemriaatifoonraTloxSitcaonldoagridcizPaattihoonloogfy, 1994-1995, PresCiode-nCth-aEliercmta,nTh19e85S-oPcrieesteyntof. Toxicologic Pathologists, 1999-2000. , . PPraesstidPernets,idTehnte,STohcieetSyocoifetTyoxoifcoTlooxgiiccolPoagtihcolPoagtihsotlso,gi2s0t0s,0-22000011-.2002. ie Lo* ngNoRrtahngAemePrliacnanninDgirCeocmtomri,ttIentee,rnAamtieorniaclaAncCaodlelmegyeooffTTooxxiiccoollooggiyc,P2a0t0h2o.logy, ! FDA20C0li2n.ical Pharmacology Subcommitteeof the A Advisory Committee for Pharmaceutical Sciences, FDA Center for Drug Evaluation and Research, 2003. 2 rn . EDITORIInAteLmaRtEioVnIaElWAgBeOnAcyRDfo:r Research on Cancer (WHO), Classification of Rodent Tumors, Part ll The Mouse, 1995-2001. EditoTroixailcRoelovgiyewBoBaoradrdoffoPrubFluincadtaimoensn,ta1l99a6n-d19A8p8p.lied Toxicology, Soci.ety of EditoorfiaPlubRleicvaiteiwonBs,oa1r9d96fo-r20To0x4icological Sciences, Society ; of Toxicology Board . Editorial Review Board for Experimental and Toxicologic Pathology, 2000. PFaUcBtoLrIsCpArTeIdiOsNpSosAinNgDoPuAroPlEitRhSia:sis in feedlot cattle. Hardisty JF and Dilan RC. The lows State University Veterinarian, lowa State University, Ames, low, 33(2), 77-81, 1971. CRaesdtuicetbieornroyfMfWr.eqIunenPcryocoefehdiipngdsy,spClaasniianeinHmiipliDtyarsypldaosgis.a SRyimsperosWiHu,mHaanrddiWsotyrkJsFhoapn,d GFA, Columbia, MO. 1672. SGceanleetriac SinEf,luCeanscteloefbetrhreymMalWe oanndthReisienrciWdHe.nceInofPrcoacneiendeinhgisp,dyCsapnlaisniea.HiHparDdyissptlyasJiF,a Symposium and Workshop, OFA, Columbia, MO. 1972 24 EPL PY sevssringinmase . JERRY F. HARDISTY, D.V.M. - Continued t PEvUaBluLaItCioAnToIfOtNhSe eAfNfeDctsPAofPcEhRemSic=aClocnotmipnouuendds on the re. productive system of rat2s. Hardisty JF. Presentedat the Biomedical Laboratory Review and Analysis, April 1875. RBeipormoedduiccatlivLeabsotrudaiteosrywiRtehvqiueiwntaensdsAennacleysciosmopfouQunidnst. EHsarsdeinsctey,JJF,anPuraersyen1t67e6d.atthe EEfdfgecetwsooofdKAZr/sIePnmailxtTuercehnoincatlheRerpeoprrto,du1c6t7i6v.e system. Ha.rdisty JF and PellerinRJ. . RBeipsrkoudpuRctFivaendstMuadniteshewiitJhH.diEsdogpreowpoloydmeAtrhsyelnpahloTsepchhantiecianlfRatesp.oHratrAdiRsCtySLJF,TRPe7l7le0i8n7,Ry, May 1977, v QPuaatlhiotlyogayssWuorraknscheoipn,paBtehtohleosgdy.a, Hardisty JF, Ward MD, June 1978. JM and Griesemer RA. NCLNCTR " WMoornkosnhuocpl,eaBrectehlelsldeau,keMmDi,aJiun nFeis1c7he8r.344 rats. Hardisty JF. NCI.-NCTR Pathology QDuGa,liGtryiaessseumrearncReA,foHrapradtihsotyloJgFy,iSncrhoudeelnetrcRaLr,ciSnqougierneesRiAs taenstds.StWraanrddbeJrMg,JGDo.oJdoumrannal of Environmental Pathology and Toxicology, 2, 371-378, Nov.-Dec. 1678. dNieaompilnaoasnmissoalnedspuiifgamteen,taathiaoinr odfyethceotmhpyoroniedntg.laWndaridn FJ-M3,44Striantssone,xpSoFs,eHdartdoi2s.t4y-JF, Cockrell BY and Hayden DW. Journal of the National Cancer Institute, Vol. 62, No. 4, April 1878. Rdiebnraolmocparrocpiynlo)gepnhiocsapnhdatnee]phinroFt-o3x4i4c reaftfsecatnsdofBtEhCe3fFl1ammeicreet.aRrdeaznntikTRGI,S[W(a2,r3d- JM, H1a97r8d,isty JF and Russfield A. Journal of the National Cancer Institute, Vol. 83, No. : 1, July Cmoircrreolsactoipoincableltywienecnargcrionsosgeonbesseirsvabtiiooanssosafystuimnorrasts.anKdulnweiocphlBaAs,msHadridaigstnyosJeFd, Gilmore CDeEcaenmdbeWrar1d676J.M. Journal of Environmental Pathology and Toxicology, 3, 281-287, Ecvaarlcuiantoigoenneosfipsrtoecsetdinugrepsrosgurgagme.stHeadrdfiosrtyreJdFu,ciWnagrtdheJMp,atDhooulgolgayswoJrFkalonaddFienaars TR. Journal of Environmental Pathology and Toxicology, 3, 167-176, December 1979. . i y. # ! 25 CED ssn . JERRY F. HARDISTY, DV.M. - Continued i PCaUnBcLeIrCiAnTduIcOtiNoSn fAoNllDowPinAgPsEinRgSle=anCdonmtulitniupeledexposures to a constant amount of vinyl cahnldorHiadredmisotnyoJmFe.r.PrHeesheinrteRdM,forMtchNeacmoanrfeareBnPc,eMtcoLraeu-gehvlailnuaJt,eWtihleiTgoaxniDcAol,oBgyieofrVbionwyleGr CahtitohreidNeatMioonnaolmeInrs,titPuotleyvofinHyelalCthhi,orBiedtehaensddaS,trMuDc.tural Analogues on March: 20-21, 1880, Cchalnocreidreimnoduncotmieorn.folHleohwiirngRMsi,ngMlceNaanmdamrualtiBpPl,e MecxLpaousguhrieisntoJ,aWiclolnisgtaannDtAa,moBuinertboofwveirnyGl `and Hardisty JF. Environmental Health Perspectives, 41, 63-72, October 1981. CKoarrncrieniocghenMe.siTshebiTooaxsiscoalyoogfis2t,,6-VXoyll3d,inNoe. in1,raMtas.rcHhard1i9s8t3y. JF, Monigomery CAand ~~, . "GibCshroonnicJtEoxiacnidtyHaanrddiostnycoJgFe.nFcuintdyabmieonatsaslayanodf AipnhpallieeddtoTolxuiecnosloingFyi,sc3:he3r1354-431r,ats1.983. QMuoanltigtoymaesrsyu,raJnFceHairndipsattyh,olSoLgyEufsotrisr,odMeJntWcoalrfceinaongedniEcEitMyctCeosntsn,elbly.GInA: BHoaonrdmbaono,kCoAf CNaoryceisnPougbelnicTaetsitoinnsg,,1(98H5.Milman and E Weisberger, eds), pp. 34> 5-357. New Jersey: SEyCstaenmdicSeelfgfercatdsefMoJl.lowPirnegsiennhtaeladtaitonthoef fNoogrtohilCoabrsocluirnaantC,haHpatrdeirostfytJhFe, SSotceiaedtyAoGf, Grose: Toxicology Meeting on February 2, 1985. v FToaxcitcoorlsogiinfclPueantchionlgoglaybo,1r3at,or$y1-a1n0i4m,al19s8p5.ontaneous tumor profiles. Hardisty JF. PStuelvmeonnsarMyA,anldlihnegpJatWi,cJhaesaklotth RefHf,ecHtasrodfisitnyhaJlFatiaonndoSftpeeatdroAl.eTumhesmTookxiec.olGogriosste, VECo,l, No. ' 1, March 1986. p NaantdioGnAalBToooxrimcaonl.ogyIn:PrMoagnraagminPgatChoonldougyctQuaanlditDyaAtsasQuuraalntcyeoPfrToocxeidcuorleosg,ybSytuJFdHieasr,d(iBsKty HBroiosvtoelr,,eJdsK),Baplpdw2i6n3-a26n9d.ANFeUwslnJeerr.seyN:IEPrHiSn/cNetToPn --ScCieEntWifhiictmPiurbel,isChiLngDaCvoi.esInca.n,d19D8W6. PGurlomsoenEaCr,y lelfifnegctJsWd,uSetteoadshAorGt,tMeirlmleerxFpJo,sGurraehtao moiJAfo,g.StSeevlegnrsadMeAMUaKn,d HHaatrcdhisGtEJy,F,. J Toxicol. & Environ. Health 21: 173-185, 1987. AMrosoinrem:anT,oxiJcFitHyarddaitsatyf,roSmLaEcuustteisa,nRdEsuMbocrhrrisosneiyc,iHnhRalaStainodneerxspoasnudreBs.A MFoPwleMro.orTmhaen, CR Toxicologist, Vol7, No. 1, February 1987. 26 PEPL' crmee . JERRY F. HARDJSTY, DV-.ConMtin.ued " PChUrBoLniIcCtAoTxiIcOitNySanAdNoDncPoAgPeEnRiSc-stCuodnytoifn2u,e6ddiethylanilin:e. TG Pulin, RW Naismith, JF Hardisty, EB Whorton Jr. and GL Ter Haar. The Toxicologist, Vol 8, No. 1, February 1988. PMeorrigpahenraalndneJrAveSswheenabtehrgt.umIonr:sI,LSr!at,MobnyoDg.rMa.pWhaslkoenr,PaVt.hEo.loWgaylklearb,orJ.aFt.orHyarandiimsatlys,,KT nervous system, Vol 6, (TC Jones, U Mohr and RD Hunt, eds), New York, Springer- Verlag, 1988. . HPautlcmho,naErCyGerfofescet,sAdGueSttoeasdu,bcFhJroMnililcere,xJpAoGsruartheoamo,iMfoAg.St`eMvKeSneslagrnaddeJ,FGHaErdisty. gr Toxicology and Industrial Health, Vol 8, No. 1, 1990. ' : TBhoyorromiadng,laSndE,usbtyisJ,FCHaMrodnitsgtoymaenrdy,GAM BEolwoerlmlaann.dIWn: PMaatchKoelnozgiyeo,fetdhse),F3S4a4nRDaite,go(,G Academic Press, 1990. Oral cavity (pharynx, tongue, gingival teeth), esophagus and stomach, by HR Brown, JF Hardisty and Montgomery, SL M Eustis. In: Elwell and Pathology of the F344 Rat, (G Boorman, S W MacKenzie, eds), San Diego, Academic EPursetsiss,, 1C.990. TEousxtiicso.loIgn:icParlopaartehsosloignyT:oxaiccroiltoicgayl,st(aDgCelianyssotnu,dy| interpretation, by Munro, P Shubik JF Hardisty and SL and J Swenberg, eds), Amsterdam, Elsevier, 1990. y Tumors of the skin in the HRA/Skh mouse after treatment with 8-methoxypsoralen and UVA radiation. JK Dunnick, Vol 16, 62-102, 1691. PD Forbes, SL Eustis and JF Har:disty. Fund. & Appl. Tox., Proliferative lesionsof the mouse lung: Progression studies in Strain A mice. JF Foley, MW Anderson, GD Stoner, BW Gaul, Research, Vol.17, 157-168, 1991 JF Hardisty and RR Maronpot. Experiment:al Lung fLoersiHoenpsatoofctahrecirnoodgenetneisviers. inHaMredidsatkyaJFE.xpProesseednttoedWaattetrhbeoDronseeN-RNeisrposoondsieetRyellaamtiinoen.ships Workshop on December 15, 193. Procedures for peer review in toxicologic pathology. Hardisty JF. Presented at The Society of Toxicologic Pathologist 13" International Symposium on June 5-9, 1994. NToexcircooplsogyiacnPdathhiosltooglyo,gyUinnivteorxsiictoyloogficlipnaotihsolaotgyU.rbHaanradi-sCthyamJFp.aiPgrne,seJnutleyd27a,t I1n9d9u4s.trial : i" . 21 PEPL" commis mars . JERRY F. HARDISTY, D.V~Co.ntMinu.ed # APUcBoLmIpaCrAiTsIonONoSf vAeNrDtuPmAoPrEdRiaSgn=oCseosntfirnoumesdeven PCB Studies in ras. Moore John A, HPahradrimsatcyoJleorgryy,F,VoBla2n0a,s3D6e2-b3o7r0a,h1A98a4n.d Smith, Mary Alice. Regulatory Toxicology and NTeooxpilcaosltoigcy lReosuinodnstaobflqeueosntiOocntaobbleers3i,gn1i9f9i4ca.nce. Hardisty JF. Presented atthe 1994 TUosxeiocfolnoagsyalRoduindaigarblaetmosonreOccotrodbenras4a,l1l9e9si4o.ns. Hardisty JF. Presented at the ,1984. aMtotrhpeho1l0o9g4icToaxsisceoslsomgeynRtouofndptaathbolleogoincOcchatnogbees4r,in1t9h9e4.rat larynx. Hardisty JF. Presented : PRaotuhnodltoagbylepeienrNarsehvviielwlea,nTdNPoWnG,OclHaorbdeirst2y3,JF1.89P5r.esentedat he 1995 Toxico3 logy TPoexeircorleovgiiecwPiantthooxliocgoyloIgSySpNa:t0h1o9lo2g-y6.23W3a,rVdolJ.M,33H,aNrod.is2t,y 1J9F8,5.Hai|ley JR and Stree! CS. 1Co9m8p5uTtoexriiczoeldogpyatRhooulnodgtyadbalteain~Nsaushmvmiallrey, vTsN. ionndiOvcitdouablerHa2r4d,is1t9y85J.F. Presented at the Aminceevaafltueartiionhnalofatcihonanegxepsosiunrtehetoolmfeatchtyolreytehpyiltkheetloixuimmea.ndNeliwvieronpePrEo,xiBsooltmee HpFr,olLiafkeeratiion BG, Derelanko M, Rinehart WE and Hardisty JF. The Toxicologist, Vol 30, Ne. 1, Part 2, March 1996. PToexeircorleovgiyew1o7f"hAinsntuopaalthMoeleotgiyngdatian.KiHnagrdoifstPyruJsFs.iaP,rePsAenotnedNaotvethmebeAmre1r1i,c1a9n9C6.ollege of PthaethAomleorgiycpaenerCroelvleigeewofinVeatsesreisnsairnyg Pcaatrhcoilnooggiesntisc'itTyhisrtyu-diFeisr.stHaArndniusatly JMFe.etPirnegseinn'tSeedataltle, Washington on December 5, 1996. VPaaltuheoloofgtyhIeSmSoN:u0s1e92c-ar6c2i3n3o,geVnoil.cit2y4,biNoo.as6s,ay19(9S6u,mmppa.ry7)2.0-H7a2r1disty JF. Toxicologic IBlnatcekr,actAiMon Doafhcioensmu,ltJaFntHsa,rdciosnttyr,acTtGabToerrarteoriPersesaenndteidndautstIrnyd-usPtarnieall DTiosxccuoslsoigoincwith HE Pathology, Universi of linois at Urbana-Champaign, May 18, 1987. TCoonxtircoovleorgsiicaPlaitshsouleosgyi,n Uanniavteormsiitcypoafthloilnoogiys.atJFUrHbaradniast-yC.haPmrpeasiegnnt,edMaatyIn2d0u,st1r9i9a7l. : .. : . 28 PEPL ome JERRY F. HARDISTY, D.V.M. ~ Continued ' PUBLICATIONS Phenolphthalein iAnNduDcePsAtPhyEmRiSc l=yCmopnhtoimnauseadccompanied by loss of the p53 wild type Saleleelley iJnCh,eFtuerroezdy-gMoaucshpaSc3e-dkefEicMi,enFtol(+e)y mJiFc,e.LaDcuknsnGicDk,JSKt,asHiaerwdiicsztySJFa,ndHeFrrbeenrcthRAJE,. Toxicologic Pathology, Vol. 25, No. 6., 533.540, 1997. : ADniangunaolstCiLc DdaivliesmmDaVsMinFtoouxnicdaaltoigoinc pCaotnhtoilnougiyn.gHEadrudciasttiyoJnerSryy.mpPorsesieunmteadt aNtorTthheC2ar2olina S1t4a-t18e,Un1i9v9e8rsity, College of Veterinary Medicine in Raleigh, North Carolina onaJune . | MThoyursoei,d (aRndR pMaarraotnhpyorto,idGgAlaBndoso,rmbyanJFanHdarBdiWstyGaaunld, eGdAs),BoVoiremnanna., IILn,: CPaatchhoeloRgiyveorfPtrheess, ~~. . toss. : Ranoddernetlelveyadnicge cteollhtuummaonrso.geJnoesniCs:Coaorke,viGeawroyfRthKeinpehfyeslitoelro,gJye,rpryatFhoHlaorgdyi,stmye,cRhiacnhiasrmdsM, `Sharpe and Paul MD Foster, Criical Reviews in Toxicology, 2(2): 169-261, 1998. TTohxeicnoolmoegnicclPaattuhroleogoifsctesl.l dLeeavtihn:,reBcuocmcmieTnJd,aCtioohnesnoSfMa,n Faidx AhSo,c cHoamrdmiistttyeJeF,ofLSeogcriaentdy of EK, Maronpot RR and Trump BF. Toxicol Pathol. 1999 Jul-Aug27(4):484-490. eCnotnittrioevdeIrnsdiuasltriisasluTeosxiincoalnoagtyomaincdpPaatthhoololgoyg.y fHoarrtdhisetAymJeerrriyc.aPnrReesgeinstterdy oafs Paatchooulrosgey at the Ramada Inn in Bethesda, MD on Sepiember 28, 1998. . cHiosntdoupcattehdolwoigtyh ovoflnataislaelcohlefmaicctaolrsy.muHacrodsiastfyrJoFm,sGealrecmtaend iRnHh,alaHtaironketmoxaicJtRy,sLtuodmiaesx LG . and Morgan KT. Toxicologic Pathology, V0l.27. No. 6, pp. 618-627, 1989. PMaetehtoilnoggoyfWtohrekSioncgieGtryouofpsQ:uaCliutryreAnstsCuornacnecpetsi.n MHoanrtdriesatly,JCF.anPardeaseonnteOdctaotbtehre91-61"3,An2n0u0a0l. TBolixnidcoPlaotghyolRooguynd--tWahbleenPranodgrWahmeinn ANsoth.evHialred,isNtCy JoFn.OPcrteosbeenrte1d5-a1t8,th2e05010.* Annual 2`SnhdorJtR-THearyme,s.SubInchrProinnicci,plaensdanChdvMoneitchoTodxsiocfolToogxyicSotluodgiye,s,4"byEdNitHioWni,l(sWoanl,lJacFeHaHradyiesst,y ec), ISBN 1-56032-814-2, 2000. Maseetehsosdmsentto.idI:enntieyuraonpdatchhoalroagcyt.erGiazermdaevnelRoHp,meFinxtaAlS,neJuorrottnoexricBiSty, fHoarrhdiusmtaynJFh,eaClltahudriisokL and Ferenc . Environmental Health Perspectives, Vo. 108, pp. 93-100, March 2001 29 PED PL comers nv JERRY F. HARDISTY, D.V.M. - Continued " APUcBhrLoInCicATinIhOalNaStioAnNtDoxiPcAitPyE/oRnScog-enCiocinttyisntuueddy of methylthylketoxime in rats and mice. INnehwatlaotnioPnET,oxWiocoodliognyg,W1L3,:1B0o9l3t-e11H1F6,,D2e0r0e1l.anko MJ, Hardisty JF and Rinehart WE. JCAa,rcCilnaorgeenLJi,c BaasmseetstsmDe,nHtiolfdepbrreamnadftloP,xaHcairndiistryatJsFaannddmLicuec.asWhMiJt.ePKrAe,seDnatneiedlaEsMa, Botta pSoosciteetrifeosr otfhTeoSxoiccioeltoygoifc TPoaxtihcoollogoigsitcsPiantOhrollaongdyo,anFdlotrhiedaInotnemJautnieon2a4l-2F6e,de2r0a0t1i.on of sQtuuadliietsy: rTehveiewNaptriooncaelduTroexsicnoelcoegsysParryogfroarmroEdxepnetripeantcheo.loBgoyodramtaanbaGsAe,s aHnadsetomxaincoJgKe,nomic . wed Waters WD, Hardisty JF and Sils RC. Toxicol. Pathol. 30, 88-62, 2002. 4 . IenxhpaolsautiroenitnoFxiisccohleorgy34of4ocrattasm.eBtuhrylncsy-cNlaoatsetLrAa,siMoexeankes(RDGy),fKoollloewsianrgGaB3,-MmaosntthRnWo,seE-lownellly VMoRl,. 2H1a,rdNios.ty1,JFppan38d-5T3h,ev20e0n2a.z P. International Journalof Toxicology, ISSN 1081-5818, DainadgnPoastthiocldogiyleCmomuarsseinatnodxiscoylmopgoicsipautmhoilnogCyh.icPargeo,seInLtoedn Jatultyhe8,'s2TM00I2nd.ustrial Toxicology HCiosutrosleo,giRceasretiafraccths T&ridainagglneosPtairck,diNlCemomnasS.ePprteesmebnetred8-a1t0t,h2e00R2T.P Rodent Pathology 3 Ccaormbpaamraattei-vienpdruecveadlelnicvee,lemuslitoinpsliciintyf,iveansdtrapirnosgorfesmsailoen omficsep.onTtakaanheaosuhsianK,dDviinnysle GE, Foley JF and Maronpot RR. Toxicologic Pathology, Vol 30, No. 5, pp 598-605, 2002. FPirsocphyelren3e44glryactosl amnodnoBEmCe3tFh1y metihceer. (ToPxGiMcEo)l:ogiicnhPalaatthioolnogtoyx,icViotly a30n,dNcoa.rc5i,nlpgpen5ic7i0t-y57in8, : 2002. Aexnpoevsaulrueattioomneotfhyclheatnhgylekseatonxdimree.coNveewrytoinn tPhEe,oBlfoalctteorHyF,epDietrheelliaunmkoinMmJi,ceHaarfdtiesrtiynhJaFlaatnidon Rinehart WE. Inhalation Toxicology, 14:1248-1260, 2002. TFehberupaatrhyol2o9g,is2t00a2n.d pathology date. Hardisty JF. Presented at NIEHS, RTP, NC on TNahsehvpialtlheo,lTogNisotnanMdarpcahth2o0l0o2gy data. Hardisty JF. Presented at the SOT Meeting in 2T0h0e1pathologist and pathology data. Hardisty JF. Presented at FDA CEDR on May 31, 30  } JERRY F. HARDISTY, D.V.M. - Continued ' PHiUsBtoLlIogCiAcTaIriOifNaSctsAaNnDd PdiAaPgnEoRstSic~dCiolnemtmiansu.edHardisty JF Presented at NCTR in Jefferson, AR on October 31, 2002. The pathologist on October 31, and pathology 2002. data. Hardisty JF. Presented at NCTR in Je. fferson, AR |3 * The pathologist and Ottawa, Canada on pathology December data. Hardisty 2, 2002. JF. Presens ted at Health Canada in Necropsy and histology techniques. Hardisty JF. Presented at FDA on January 9, 2003. Current approaches to Peer Review and PWG. Hardisty JF. Presented at Battellein . Columbus, OH on June 5, 2003. . CChlaaryatcotnerNi,zHaatridoinsotfy iJn,traantdhoPraecaircsmeeGs.otPhreelsieonmtaedinaFsisapcohsetre3r4f4o/rNtrhaets.SocWiieltlysoonf G, Toxicologic Pathology, 22 Annual Meeting In Savannah, Georgia on June 15-18, 2003: TDrMa,nsHpalradciesnttyaJlFc,arRcuiencokgeenricFiAt,y FoufnakziKdAo,thWyomlildeinMeJinaBnEdCW3aFl1kemriVcEe.aAnbdstFr3a4c4t Nroat.s.5W48a.lker 2004 tinerary Planner. Baltimore, MD: Society of Toxicology. sCeocmtpiaornsision nanofNaTuPtoSmuabtcehdrosnoifctwBairoeawsistahy.coWnivlesnotinoGnaAl,hJiosrtoonpaTtAh,olLoegsynoifakivDe,rPsetaeprse G and Hardisty JF. Presented a poster at the STP Meeting in Salt Lake City, UT, June, 2004, Automated Toxicology Pathology Systems ~ Roundtable, Augusta, HMiu. mSaenptV. e2r0s0u4s. Machine Vision. Hardisty JF: HCaormdpiasrtaytJiFveanhdepBartiixcAtEox.iciTtoy:xipcroleocghirconPiactihcohlroognyi,c 3fi3v:e3r6t-o4x0i,cit2y00i5n.rodents. . ACTISTP ACTISTP Pathology Course for Meeting, Lincolnshire, NIoLn,-MPaatyho1l0o-g1i3s,ts2.00H5a.rdisty JF. Speaker at . , eyHARDISTY, 5 Velerinary Pathologist DA doos 31 EPL EXPERIMENTAL PATHOLOGY LABORATORIES, INC. . ; VEGTAEBRRIINEALRLYEPAATWHIOLLLOSGOINST EDUCATION; Glasgow University Veterinary School B.V.M.S,, 1978-1977 . MRC Path (Membership of the Royal College of Pathologists), 1985. + FRC Path (Fellowship of the Royal College of Pathologists), 1995 PRESENT POSITION AND EXPERIENCE: Ll 01/04 -- Present. RVeetseerairncarhyTPraitahnoglloegiPsatr,k,ExNpCerimental Pathology Laboratories, In'c., , . *. Provides pathology support to CIT, Centers for Health Research in Research Triangle Park, on + + a parttime basis. This involves interaction with staf at all level and participation in many diverse areas ranging from the technical aspects of tissue processing and necropsy techniques to study design, photography, poster preparation, image analysis, confocal microscopy, electron pmaitchroolsocgiocpaylalnesdioinmsm.unohistochemistry in addition to the rosine nYecropsy and interpretation of 09/00 - Present. VReetseerairncarhyTPraitahnoglloegiPsatr,k,ExNpeCrimental Pathology Laboratories, . Inc., Duties as a staff pathologist in present position at EPL include histopathologic interpretation of tissues from various laboratory animals and audits of pathology data and specimens used for toxicity and carcinogenicity studies. 03/00 - 07/00 ASancartaommeinctPoa,thCoAlogist, IDEXX Veterinary Services, West Responsibilities included performing histopathology on research studies submitted by independent biotechnology companies, pharmaceutical companies and university departments. iso, in par, provision of diagnostic histopathology service for veterinary cinicians. 12/86 - 12/89 Veterinary Surgeon, The Animal Care Centre in Sharjah, United Arab Emirates Functioned in a cinical capacity as a veterinary surgeon. 10/01- 12/96 Independent Toxicological Pathologist, Histo-Logic, Stalybridge, Cheshire UK 32 EPL EXPERIMENTAL PATHOLOGY LABORATORIES, INC. . GABRIELLE A. WILSON, B.VILS., MRC Path, FRC Path - Continued PRESENT POSITION AND EXPERIENCE - Continued SinidnecpeeAnudgeunsttp1a9t9h1o,lofguyncctoinosnueldtaanscya.coPnesruflotramntedpaptahtohloolgoigsty eosntaablniushmibnegrHiofstsot-uLdoigeisc,aannd also ppeerrffoorrmmeedd pineehrourseevi(eWwasroef)sotfudaitecsofnotrraGcltafxoacWieellscaonmdeo(fWneercee)s.siTthyeisnevosltvueddiedsowseerleiaeiistohnerwith the other scientists involved. : Rlaebaordataorviaersieitny booftshttuhdeieUsniinteradtsK,imnigcdeo,mdoagnsd aenlsdemwihneipriegisnfEourrcoopnet.racHtisatnod-Lootghierw,aphsaramcacceeputteidcal into the United Kingdom Department of Healths GLP Compliance programme: o 10777 - 08/91 Senior Pathologist, Unilever Research, Shambrook, Bedford UK + " tReerspmotnessitbsilintireosdeinntcsl.uded postmortem and histological assessment of short, medium and long- AacntdeadtacsonSttruacdtylDaibroercattoorrifeosr. all teratogenicity studies for several yars conduced both in house Management of the Teratology Department with direct responsibilty for a staff of four. ' Achievements During This Period: .' Cinosmtpillaettioino,nionftarepllaerugrealnaunmdbeinrtorapteersittsoneenalcoimnjpeactsisoin,ngntfreaevdaignign,eilnhiansltaitliloant,ioninarnadtftaocphiecaall aapspplaircattoifon.theUletvraalsutartuicotnuraplroecxeasmsi.nation and histochemical assessment were frequently required . Sinovleestriegsaptoinnsgibtihletfyeftorimteheefhfiescttosloogficfablraosussemsisnmereanlts.of a vast and complex ntrapleur:al study Production of reports, most of which were submitted to Regulatory Authorilies. OUnvievresrsseitiyngMeadiscuaclceSscshfoulolcoilnltahbeoraarteivaeopfrionj-evcittrwoittehcthhneiqAuneastfoomrythDeeapsasremsesnmtenotf Lofeiecmebstreyro wcuhletruree.it wThaissutsecehdniiqnuethewaassselsetsemretnrtanosffeprorteednttioalthteerEantvoigernosn.mental Safety Laboratory at Unilever Formal presentations of results of studies both within Unilever and to the operating companies. Cgaurirnyeiangpiogus,t rbaabcbkitgsroaunnddirnveessetairgcahtitoonmoafisnpteaciinfitcheprhoeballetmhs.of the breeding colonies of rats, mice, 33 EPL EXPERINENTAL PATHOLOGY LABORATORIES, INC. "GABRIELLE A. WILSON, B.V.M.S., MRC Path, FRC Path- Continued PRESENT POSITION AND EXPERIENC-E Continued | : 0777 - 1077 SLuorcbiutmonw,orsku,rrHeeynUdKerson & Keywood Veterinary Surgeons . Lprooccuemdurweosr,k eitnca. busy small animal practice. Duties includ:ed consultations, surgical PROFESSIONAL MEMBERSHIPS: . FBreiltlioshw SoofctihpetyRooyfaTloxCioclolleoggeicoaflPPaatthhoolloogigsyts CSohcairelteysofLoTioxsicDoalviosg,icDP.aVt.hMo.lFooguyndation . : $A ) . PRESENTATIONS AND POSTERS: DIinsdcuucsesdioMnesGortohuepl,io2m2andinMteheetiWnigs,taLrlaRnadt.udnWiol,lsNoonr,thG,Waplreess,enSteepdtaetmtbheerI1n9du9s2t.rial Histology p`rSepsoennttaendeaoutsthaendBSInTdPucMeodduPlaatrhoEldougcyaotfiotnhePSraolgivraarmymGelainn dTsoxaincodloOgeiscoaplhPaagtuhso.logWyi,llCsaomnbGr,idge, England, July 20, 1993, CMaordduiloavrasEcduulcaartiSoynstPermo:grSapmomnetainneToouxsicRoloodgeinctalPPaatthhoollooggyy., WCialmsborni,dgG.e,, pErnegsleanntde,dJautlyth9e-1B2S,TP 2001. . ` Hepatoblastomas in Mice in the US National Toxicology Program (NTP) Studies. Turusov VS, TaotrtihieM,STSiPllsMeRsCt,inWgilinsoDnenGvAe,r,HCerOb,erJtunReA,2-H6a,i2le0y02J.R, Haseman JK and Boorman GA, presented HChaarrdaictsetrJyizaantdioPneoafrIsteraGt.hoPrraecsiecnMteedsoatshealpioosmtaerinfoFritshceheSroc3i4e4/tNy'oRfatTso.xicWoillolgsiocnPGa,thCollaoygtyo,n2N,2 Annual Mesting in Savannah, Georgia on June 15-19, 2003. Toxicologic Pathology of the Integumentary System and the Mammary Gland. Wilson G. Presented to the Health Products and Food Branch, Office of Continuing Education, Ontario, Canad on January 20, 2004. The Use of Automated Pathology Software to Confirm the Results of Pathological Evaluation of NTP Studies. Pearse atthe STP Meeting in GSa,itJoLraokneTCAi,ty,LeUsTn,iaJkunDe,,W2i0l0l4s.on GA and Hrdisty JF, presented a poster 34 EPL EXPERIMENTAL PATHOLOGY LABORATORIES, INC. " ; : GABRIELLE A. WILLSON, B.V.M.S., MRC Path, FRC Path - Continued PUBLICATIONS AND PAPERS: - | `SeCcotmipoenrsisionnaonfNATutPoSmuaotcehdroPnaitchoBlioogayssSaoyf.twWairlelwsiotnhGCAo,nvJeonrtoinoTnaAl, HLiessntioapkatD,hoPleoaogrfyseLiGvearnSdtep Hardisty JF, presented a poster at the STP Meeting in Salt Lake Cty, UT, June, 2004. tMhoeduplroeg1r3a:mMmues)c,ulBoSskTePleMtoadluSlyasrtEedmu,caStkiino,nSPurbocugtriasmamnediMnaTmoxmiacrolyo,gGilcaalndP.atWhiolllosgoyn,GCa(mobrrgiadnigzee,d 5 England, July 5-8, 2004. y `PaGtohmoela.l1L8i8p0eiJduols;i1s7(i4n)2:4D9o0-g3.with Biateral Thyroid Carcinoma. Harrington GA andKellyDF. Vet , . A Lymphomatoid Granulomatosis of the Lungs in Young Dogs, Lucke VM, Kelly DF, Harrington GA, Gibbs C and Gaskell CJ. Vet Pathol. 1979 Jul:16(4):405-12. E HToerpiatMo,blSialsstoRmCa,sWiinllMsiocneGiAn,thHeerUbSerNtatRiAo,naHlalTloexyicJoRl,ogHyaPsrsoagrnaJmK(NaTnPd)BSotourdimeasn. GTAu.rusov VS, Taxicologic Pathology, Vol. 30, No. 5, pp 580-591. GABRIELLE MRC.V.S., AFRWCI.LPLaStOh.N, BVM. Date rertoe/ 157 35 CURRICULUM VITAE - 2004 . Co | NAME W. Ray Brown, D.V.M., Ph.D. : . Diplomate, American CollegeofVeterinary Pathologists PRESENTPOSITION . Consutant in Toxicologic, Pharmacologic & Experimental Pathology ~~ * President, Research Pathology Services, Inc. 438 East Butler Avenue, New Britain, PA 18901 Telephone: 215-345-7070 Fax: 215-345-4326 e-mail: WRBRPS@copoentric.net EDUCATION . Dearee\ Year ; ' PennsylUvnainviearsSittaytPearUkn,ivPeresnintsyylvania BS. 1961 New York State College of Veterinary Medicine DVM. 1964 CItohmaecla,l NUneiwveYrsoirtky New York State College of Veterinary Medicine PhD. 1967 ICtohranceal,l NUneiwveYrosirtky - Veterinary Pathology PREVIOUS POSITIONS . Independent Consultant in Toxicologic, Pharmacologic and Experimental Pathology 4 1973- prvesent Director of Toxicology and Pathology Merck Institute for Therapeutic Research | West Point, Pennsylvania 1972-1973 Director of Pathology Merck Institute for Therapeutic Research West Point, Pennsylvania 1970-1972 Senior Research Fellow of Pathology Merck Institute for Therapeutic Research West Point, Pennsylvania 1969- 1970 Research Fellow of Pathology Merck Institute for Therapeutic Research West Point, Pennsylvania 1967 - 1969 36 WC.uRaryBrroiwVnci,tuaDeVl-M2u,00mP4hO. f PREVIOUS POSITIONS (Continued) Laboratory Instructor, Veterinary Pathology New York State College of Veterinary Medicine + Comell University Ithaca, New York 1964- 1967 NIH Trainee in Veterinary Pathology New York State College of Veterinary Medicine, Come University ithaca, New York "1964-1967 ACADEMIC AFFILIATION . Assistant Professor, Department of Pathology Jefferson Medical College , . TPhhiolamdaeslphJieaf,fePresnonnsUynlivvaenrisiaty 2 ` PROFESSIONAL SOCIETIES American CollegeofVeterinary Pathologists American Veterinary Medical Association ` Pennsylvania Veterinary Medical Association International Academy of Pathology American Societyof Veterinary Clinical Pathologists `Society of Toxicology Society of Toxicologic Pathologists International Union of Pharmacology (Section of Toxicology) Charles Louis Davis, DVM Foundation Sigma Xi Phi Zeta National Veterinary Honorary Society Omega Tau Sigma Professional Veterinary Society ` OTHER SPECIALTY . Director, Electron Microscopy Laboratory Department of Safety Assessment Merck Institute for Therapeutic Research West Poi, Pennsylvania ` mid ' 37 W. Ray Brown, DVM. Ph.D. : CONTINUING EDUCATION/PROFESSIONAL MEETINGS * American College of Veterinary Pathologists , Annual Meeting . Baltimore, MD - October 31-November. 3 v 1989 "Mouse Pulmonary Carcinogenesis Symposium PE National Toxicology Program - NIEHS : Research Triangle Park, NC - March 27-28 1980 Society of Toxicology Annual Meeting . i Miami Beach, FL - February 12-15 :7 : 1990 | : American College of Veterinary Pathologists Annual Meeting Phoenix, AZ- December 10-13 1990 Society of Toxicology Annual Meeting : Dallas, TX - February 25-28 ` 1991 Drug Information Association Recent Considerations on the Design, Interpretation and . * Evaluation of Rodent Carcinogenicity Studies . Rockville, MD - September 30-October 1 ` 1891 American Collegeof Veterinary Pathologists Annual Meeting Oriando, FL - December 9-13 1991 Society of Toxicology } Annual Meeting Seattle, WA - February 24-27 1982 Societyof Toxicologic Pathologists Xi International Symposium Toxicologic Pathology of the Hematopoietic System Phoenix, A-Z May 31-Jun4e 1982 National Research Council Role of Toxicologic Pathology in Safety Assessment Washington, DC - February 8-9 1993 38 WC.uRary BiroewVni,utaDelV-uM20,m04PhD, ! CONTINUING EDUCATION/PROFESSIONAL MEETINGS (Continued) ASnocniueatly MoefeTtoixnigcology , I New Orleans, LA-March 15-10 1803 SXolciIenttyemoaftiToanxaiclaSloygmipcoPsaituhmlogists ' RegulatWiaosnhsiGnogvteornn,inDgCT-orJiucnoelo2g7i-cJPulayth1ology : . 1003 RGirsokwtAhssFeascstmoresntan(d7TuInmtoerrnaPtrioomnoaltiCoonn:feIrmepnlicceatoinons for Carcino`gAeusnteisn,isTaXn-dDiesckemAbsesres1s-m4ent) . . : 1903 vow? y 5In"tWeornraktsiohnoalpLoifne MSociuesneceLsiveInrsTtiutmutoers ' ' ' `Arington, VA- November 7-9 1004 SAoncniueatly MoefeTtoixnigcology Baimore, MD - March 5-0 : 1005 S1o4c7iIenttyeomfatTioorniaclalSoygimcpoPastihualmogists San Diego, CA - June 11-15 1005 TSwtaog-idnagyosfhRoartt cToeusrtsees by Dr. L. Russell Rohm a`nSdpriHnagaHsouCsoem,paPnAy- February 26-27 f 1806 SMipcr-iAnlglaSnctiienctCifhiacptMeers,tiSnogciety of Toxicology Kenworth, NJ -April 25 ! 1085 S1o5c%ieItnyteomfatTioodneaolloSgyimcpPoastihuomlogists ToxicoloSgt.icLoPuaitsh,olMog-y JaOundneRi5s-k13Assessment 1986 A`AmnenruiaclaMneeCtoilnlgege of Toxicology Valley Forge, PA - November 11-13 1866 39 "CuWr_riRcayulBuromwnV,itaDeV-M2.00P4hO. . : ` : CONTINUING EDUCATION/PROFESSIONAL MEETINGS (Continued) Society of Toxicology Annual Meeting ' Cincinnati, OH - March 8-13 4 1997 Society of Toxicologic Pathologists 16" Intemational Symposium . Toxicologic Pathology of the Kidney and Urinary Bladder Beaver Creek, CO - June 22:26 1897 American Collegeof Veterinary Pathologists Annual Meeting Albuquerque, NM - November 16-21 " w: eer , "Society of Toxicology . Annual Meeting : New Orleans,LA - March 14-18 1999 Society of Toxicology Annual Mesting 4 Phiadelphia, PA - March 19-23 2000 Society of Toxicology Annual Meeting Nashville, TN - March 17-21 | . 20)02 Charles Louis Davis, DVM Foundation i Altematives to the Rodent Biosassay in Assessing Carcinogenicity New Brunswick, NJ - April 5 . 2002 . American College of Veterinary Pathologists Annual Meeting New Orleans, LA - December 7-11 2002 Charles Louis Davis, DVM Foundation Dermatopathology Symposium New Orleans, LA - December 7 2002 American College of Veterinary Clinical Pathologists Annual Meeting New Orleans, LA - December 7-11 2002 40 ' Curculum Vitae -2004 W. Ray Brown, DN.M. PD. CONTINUING EDUCATION/PROFESSIONAL MEETINGS (Continued) Charles Louis Davis, DVM Foundation Gastrointestinal Toxicologic Pathology New Brunswick, NJ-April 25 2003 PATHOLOGY WORKING GROUP (PWG) PARTICIPANT "National -Dioxin- Toxicology Program Re-evaluation of hepatic tumors from the 1978 Kociba rat -Dioxin- study (1990) Participant at the Banbury Conferences (Cold Spring . Harbor) . on the -PCBs-Re-evaluation results of the of the rodent riev-eervtaluumaotrisonfroofmthteheraAtrloicvleorrtumors (1850) . ": : g1e2n5i4ciayndrat12st6u0diaensdC(1l8o9p1h)enA30 and ASO chronic/onco- 3 . ~Several industrial-sponsored PWGs pharmaceuticals on chemicals, agrochemicals ` and HISTOPATHOLOGY PEER REVIEW for Peer review of several domestic hainsdtoipnattehronlaotgiyonasllidpehsaarmnadceduattiacahlavaenbdeecnheamnidcaalrecobmepiangnipeesr,fotrrmaedde groups, and consortiums on toxicity and carcinogenicity studies. EXPERIENCE IN TOXICOLOGY AND PATHOLOGY the desiAgctni,vistuepseravsisaiocno,nseuvlatlaunattiionn,toxaincdolorgeipcoratnindgpohfartmoxaiccoiltyogaincdpactahroclinooggyenhiacvietyinsctluuddieeds involving various chemical and potential therapeutic or biologic substances. Laboratory caantism,aldsoguss,ednoinn -thhuemseanstpurdiimeastienscl(uRdheersoudse,ntcsyn(roamtso,lgmuicse,anhdamAsftreircsa,n guinea green pigs, rabbits), monkeys and mTahremotsypeetss)o,f veaxrpieoruismeanvtisaninsptehceiaerse(acshiocfkiennsv,oldvuecmkesn,t thuarvkeeysb,eequnaiolr)a,l atnoxdicmiitynieaxtpuerreimsewnitnse,. inhalation exposure and subcutaneous studies, irritation sptaurdeinetse)r,alcasrtcuidnioegsen(iicnittryaveexnpoeursi,meinnttrsa,mursecpurloadru,ctdieornmtaelr,atoocluolgayr studies, and histologic evaluation for safety tests of various vaccine preparations terpretaRtieosnpoansnidbidlettiaeisledinreptohretsieng various experiments of antemortem data have (clinical included signs of evaluation, toxicologic inand pphoasrtmmaocrotleomgicdaetffaects()o,rgealnectrwoeciagrhdtiso)l,ogy,grhoesmsatolaongdy, serum biochemistry, microscopic tissue urinalysis, and examinations, histochemistry and electron microscopy. 41 W. RayBrown, DVM. PhO. Reporting of the above data has included preparation of summarizations of the methods and results, conclusions, and safety assessment of the various agents based on the results. These reports are written in appropriate formats for submission to international `and domestic regulatory agencies, e.g., suitable for submission for Investigational New Drug (IND) and New Drug Application (NDA) with the Food and Drug Administration, U. S. DepartmentofAgriculture, National Cancer Institute and Environmental Protection Agency. In addition to primary project participation arid monitoring, peer review experience has included selection as the Society of Toxicology Task Force pathologist to perform an independent pathology review of the urinary bladder and hepatic neoplasms in the FDAINCTR ED, mouse carcinogenicity study and participation in several'select panels and committees for review and interpretative opinions on pathology sides and data for various, ' sponsors, as wel as international and domestic regulatory agencies. Manyofthese reviews . : and representations have involved findings and interpretation of hepatic and endocrine toxicity and potential oncogenic. 42 W.Ray Brown; DVM. PhD. . PUBLICATIONS: 1. SChtruidsiteisan,in MC.RSL. aSnpdraBgruoew-nD,awWl.eRy.,(*CGoonltdroSltaPnrdiamrodr"d)iaRlatFosl,liTcolxeicCooluongitcs, iSnciMeunlciegse,ne6r6a:t1-iSo,n 233 (2002). 2. YRoerpkr,oduRcGti,on SBtruodwyno,f AWmRm,oniGuimrarPde,rchMloFr,ateainndDriDnoklilnagrhWiadte,er J(.iSn.p,resTsw).o-Generation 3. Crzan, Hardy, G, Cushman, JR, C.J, Coombs, Andrews, LS, Granville, DW. Mulins, PA. G.C., aid Johnson, Brown, . KA. Bevan, C., WR, Chronic Toxicity/Oncagenicity Study of Styrene in Weeks. J. Applied Toxicology21:185-18 CD-1 Mice (2001). by Inhalation Exgosure i for 104 4. CCrouozmabns,,G.D,.WC.u,shMmulainn,s,JPR.,A.AnadnrdewBsr,owLnS,.W,.GRr.a,nvCihllreo,niGc.CT.o,xiJcoihtnys/oOnn,coKgeAn.i,clHtayrdSyt,uCd.yJ.of -. Styrene in CD Rats by Inhalation, Exposure for 104 Weeks. Toxicol. Sci. 46:266-281 (198) , : ' 5. Forbes, P.D., CP, Brown, Takizawa, T., WR, and Hashimoto, K., Parker, RM. Y7a8m-aWsehietka,PSh,otHoocbaercrimnaong,enAeMs.i,s Sambuco, Study of TGorxeipcaoflioogxiaccailnSciaenndcesC,o4m2p:a1r-a5t,o5r0-5A1r,ti1cl9e9s8.Administered Orally to Hairless Mice. 6. Sambuco, C.P., WR, Stahle, PPoLw,ers,StWr.eetJe.r,,DemApJs.tera,ndM., PHaorbkeerr,manR,MA.M.,1F3o-rWbeees,k P.SDu.,bcBhrroownni,c HPahiortloetsosxiMcicoel.ogTyoxSitcuodlyogiocfalleSvcofileonxcaecsin,,42A:1Q-uS,in5o1l,on1e99A8n.tibiotic, Administered . Orally to 7. Parker, WR, RM., Stellar, Powers, SM. SWt.rJe.e,teDre,mpAsJt.er,aAnMd.,FoHrobbese,rmaPn.,D.,AM.1,20SMaomnbtuhcoO,raCl.P.(,GaBvraogwen), 4P2ho:t1o5c,ar5c1i,no1g9e8n.icity Study of Levofloxacin in Hairle: ss Mice. Toxicological Sciences, 5 8. iMnanFliesyc,heAr,3B4r4owRna,tsW: RL,ackanodf Mennear, Effect of CJ.:hrDoincihcioArdvmoisniasntdratMioonnononucPeraorgrCeeslslioLne.ukofemtihae Disease. International JournalofToxicology, 16:1-7, 1997. : . SBtruodwine,s wWi.thRL:-tryCpotmoppahraantainvde CHoinssttoiptuaetnhtosl.ogiJcouErvnaalluaotfiRonheoufmaAtnoilmoaglyS(t2u3d,ieSs:upplMeumreinnte 46), 99-110 (1996). 10. PPraotltiefresroant,ive DlRes,ionsHaofmitih,e MH. adrenal gHoltatnednsdoirn!,ratsG.H.I,n GuGioduegsh,forA.TaxaicnodlogBircowPna,thoWloRgy., STPIARPIAFIP (1995). 11. Brown, on the W. Rat R, Fetter, A. D., Van Ryzin, R.J. and Pituitary. ToxicologicPathology21(1): Langloss, JM.: 81-86 (1993). Effects of Calcitonin 43 WCu.rRraiycuBlruomwVni,tDaeV.- M20.04Ph.D. . . . "* PUBLICATIONS (Continued) 12. tMhceGeToex,icJ.olHo.,gyBautnlder,CaWr.cHi.n,ogWeinlelsgiasn,StD.udAi.,esBorfowlno,diWna,teRd.,GlayncderSoolfiian, FR3. 4D4.:/NCRriaitqsueanodf BEC3F1 Mice. Regulatory Toxicology and Pharmacology 18, 169-180 (1983). 13. PNreowlbifeerrnatei,vePL.iMve.r Carlton, Lesions W. W., in Rats and Fed Brown, W. R. trans-Anethole Histopathological Evaluation' of in Chroni Studies. Food and Chemical Toxicology 27(1): 21-26 (1989). ` 14. WHaegeakn,WhJ.olV.e,-BFiosdhyer,aJn. dR.,NosBreo-wOnn,lyW.InRh.alaatnidonBaTlodxwiicni,tyR.ofC.M: aCnocmopzaerbisoinn of the Rats. TwoThe Toxicologist 7(1): 196 (1987). hah . 15. MDiazyenFse,eMd.i,ngBroSwtnu,dyW.anRd., OLnaev-eGgeinae,rJa.tiKoinlleRene,prJo.dCu.ctainodnIgSntautdosykii,n J.RaAt:s CwoimthbiEntehdyl350- * } Cyano-3,4-Diphenyl-6-OXO-1[6H}-Pyridazine-acetate 17 (1984). ' (DS-29399). The Toxicologist 16. FAo:rd,AW.30-H.D,ayAulTeotxtiac,itCy. S., Brown, W. Study in Dogs Rw.i,thLaEvtehgyllia5,.CJy,.anKoil-l3e,e4n,-DJi.p-hCe.naynl-d6-IgOnXaOt-o1sk[i6,H]J-. Pyridazine-acetate (DS-29399). The Toxicologist 4:18 (1984). 17. GFoenedgiwnegr,StLu.dEy.,ofAuA-l1e3t2t-aC1,.32S0.,inRTihnreeheaSrttWr,a.inEs.,ofanFdemBarloewnR,atWs., RRe.;poMratnnoiftIoClI IAl: meLirfiectaism,e (In4c.v,olWuimlemsi)n,gtDoonc,kDetEs aMnadnaBigoelmdeynnatmiBcrsa,ncIhn,c.,FDEAa,stRoMciklvlisltloen,e,MNDJ.(19D7o8c)k.et No. 74-2186 . 18. AEdmeenroyv,irJ.usB.T,ypHeous2e,byJ. CaAn.,inaendAdBernoovwinr,usW.TyRp.:e Cross-Protective 1 Vaccination. Immunity American to Canine Journal of Veterinary Research 39(11): 1776-1783 (1978). 18. Goldlust, Differing SM.chBe.d,Ruilcehs,foL.r GI.n,traan-adrtBircuolwanr,CWh.alRl.e: ngIemmwuitnheASnytniogveint.is in Rabbits.Effectsof American Journal of Pathology 91(2): 329-343 (1978). 20. Apostolou, on Water ACo,nsSauimdptt,iLo.n,,anBdodBryowWne,igWh.t,R..BlEofofdectSoafmpOlvienrgn,ighatndFasBtlionogd.ofCoYmopuonsgitiRoant.s Laboratory Animal Science 26(6): [Part 1], 959-960 (1276). 21. LZueivcokdeoyp,a.R.ToEx.i,coBlroogwyn,anWd.ApRp.lieetdaPl:haPrrmecalcionlicoaglyT2o9x:ic1o8l1o-g1y95St(u1d6i74e)s. of Carbidopa and 22. DBroogwnI,ndWu.ceRd.,byRuabiSnal,icLy.l,anHiiltied,e.M. TaonxdicZowliocgkyeay,ndR.ApEp.l:ieEdxpPehrairmmeantcaolloPgaypi2l1l(ed)d:em5a32i-n5t4h1e (1872) 23. Brown, W. Laboratory RA.:niSmiaglnsifuiscaendceinofPhSapromnatcaonleooguys Diseases Research. of the The Central Nervous System in Laboratory Animal in Drug Testing. Germany, F1i9f7t2h.International Committee on Laboratory Animals Symposium, Hanover 44 " CW. uRaymBrcowVuni,tatDeV-uM2.0m08PhO. , ; . : PUBLICATIONS (Continued) 24. TWhatesonEl,eLc.troS.l,yRtieleyE,xcRr.etLi.o,nConPnaetlltye,m M:ofT.,ARmuisosroi,deH. F, Brown, Following W. R. and Ureteral Baer, J. E.: Retrograde Intraluminal Injection. Federation Proceedings 30: 337 (1871). 24. VLoacnalArScmhawnaC,r.tGz,m,aCnarRleascotni,on.R. PP.r,oBcereodiwnngWs,.ofR.thaenSdolciikient,yAf.o:r EIxnpdeormiemtehnatcailnBIinohliboigtysafnhde Medicine, 134(1): 163-168 (1970). 25. WVheittelroicnka,riaR.n LHI.X(a4n)d: B5r1o5w-n5,24W.(19R6.:9)C.hronic Cholangiohepatits in the D.airy Cow. Cornell 26. dBirsoewans,e.WD.erR,TiKerrozouk,chLt. 2ea0rn:d54P6o-n6d4,7 W(1.96G8.):. Atiophic Rhinitis in S;wine. A nutritional EA" 27. SMcyootct,arMd.iuLm., aOnldsoonf,SGm.o,otKhrooMku,scLl.e,Birnotwhne, YWo.unRg.:PoSuetl.enJiouumr-nraelspoofnNsuitvrietiMoyno8p1a(tah):ie5s73o-f + ` 583 (1967). . 28. aBrnodwPnr,opWh.ylRa,xisK.roCookmLe.l,lPoVnetde,riWn.arGi.a:nALtVrIo,pShiucppRhlienmietinstinNoS.wi1n,e1.-E1t2i8ol(o1g9y6,6)P.athogenesis 29. VBertoewrni,naWr.y PRr.a,ctKircoeo4k7,(9L).: a3n8d-4P5o,nAdu,gWu.stG1.9,66A. New Lock at Atrophic Rhinitis. Modern 30. `KArtorookp,hicL.R,hPinointids.," 1W. .NutGr.itioann.d PBrroocwene,diWn.gsRo.f tDhiee5t7ar%yAnCnaulcailuMmeeatnidngoPhfotshpehoArmuesriacnadn Societyfor Animal Science. J. Animal Science 24: 892 (1965). + : 31. APtornodp.hiWc.RhiGn.i,tisK.rookP,rocL.eeadnidngsBrfoowrn,theW.19R6.:5 DCioemtealrly CNuatlrciitiuomn aCnondfePrheonscpehofroursFeaendd Manufacturers. Buffalo, New York (1968). `BookChapter ! . 1. CBhrroownni,cWR.atR.B,ioImapslsiacyatiinon"sBiooflotghiecalReBeaxsaimsinfaortiRoinsokfAstsheesLsimveerntSeocftiDoinosxifnrsomantdheReTlCatDeDd Compounds', Banbury Report 35, Gallo, M. C. A (eds.), Cold Spring Harbor Laboratory PAr.e,ssS,ch1e9u9p1l,eipnp,. R1.3-J2.6,. and van der Heijden, WR 8 W. Raysof DVM, PhD Veterinary Pathologist Meg 11 200 Date 45 1 June 2003 : 2 CURRICULUM VITAE Name: Er3n0e2s8t EE.thMcaCnoLnanneell, DVM, MS (Path) ge Raleigh, NC 27613 DP atel & aocf Bierth:OrNrovivlelem,bOehri1o4, 1037 : .k Citizenship: United States 2 2 . 1199555-7- 11996517'-- PD.rVe.vMe.t,eTrihnearOyhMieodiSctiantee,UTnihveerOshiitoy State University .g * 11996654-- 11996667 -- RM.eSs.,idDeenpta,rVtemteernitnaorfyPPaatthhoollooggyy. DMiivcihsiigona,nASrtamteedUniFvoerrcseistyInstitute of Pathology, Washington, DC BoardCertification: DDiipplloommaattee,, AAmmeerriiccaann CBoolalredgeofofToVxeitceorliongayr,y1P9at8h0ologists, 1968 BrCieh f ronoofElmploovignenyt: Jun 1961 - Aug 1961 Small Animal Practitioner, BeckerSmallAnimal Hospital, Columbus, OH Aug 1961 - Aug 1961 First Lieutenant, US. Air Force, Gunter AFB, Montgomery, Al Oct 1961- Sep 1964 Base Veterinarian, Hill Air Force Base, Ogden, UT , LansSienpg,19M6I4 - Sep 1965 Graduate Student, Department of Pathology, Michigan State University, East Sep 1965 - Oct 1967 R`eWsaisdheinntg,tVoent,eDriCnary Pathology Division, Armed Forces Instituteof Pathology, PatOhocltog1y9,67 - May 1969 Veterinary Pathologist, Aerospace Pathology Branch, Armed Forces Institute of Washingion, DC May 1969 - Aug 1972 VPeattehroilnoagryy,PWaatshholionggitsotn,,GDeoCgwriatphhidcutPyatihnolthoegyPDaitvhioslioogn,y DAerpmaerdtmFeonrtc,esVeItnesrtiitnuatreyof Research Institute, Onderstepoort, Republic of South Africa 6 Aug 1972 - Aug 1974 Chicf, Pathology Branch, Toxic Hazards Div., 6570 Aerospace Medical Research : . Lab., + Wright-Patterson AFB, OH . . : : PathAoulgog1is9t74n-dNov 1978 Veterinary Pa=thologist (Grade 03), US. Public Health Service, Research + . ` HeaSdc,ieCnocmepsar(NaItEiHvSe),PRaetsheoalrocghyTSrcieatnigonl,ePNaartki,onNaCl.Institute of, Environmental Health Nov 1978 - Jan 1984 Veterinary Director (Grade 0G), NIEHS, Chief, Chemical Pathology Branch, , Toxicology . " Research and Testing Program, Research Triangle Park, NC Sep 1983 - Jan 1985 Veterinary Director (Grade 06). NIEHS,ActingDirector, ToxicologyResearchand ~ Testing Program, Research Triangle Park, NC : Jan 1985 - Oct 1988 Veterinary Director (Grade 06). NIEHS, Director, Divisionof Toxicology Research, and ' ve Testing Program, Research Triangle Park, NC y Oct 1988 - present President, ToxPath, Inc., 3028 Ethan Lang, Raleigh, NC : A`Auvgg 11900714 --OAcutg 11908754:: UUSS..APuibrliFcorHceealth Service %. A`ammeerriiccaann VAestseorciinaatriyonMefdorictahleAAsdsvoacinacteimoennt of Science `American College of Veterinary Pathologists. `American Board of Toxicology `American Registry of Pathology, AFIP CNoormtmhisCsarioolnienda COhffaipcteerrs oAsfstohceiaStoicoinc,ty11.o5f. TPouxbilcioclHoegaylth Service i Society of Toxicology Sodiety of Toxicologic Pathologists Charter Member, Alumni Society, Armed Forces Inst..of Pathology Honors&Special ScientificRecognition Distinguished Citizens Award, Hill AFB, Utah, 1964 8 NUAaSdtj.iAuonincratlFADoserscfoeecniMsaeetreiStePorrrvoiifocouesssMoSered,ravSlic,che1oo9Mle6od7afl,VeWtreirgihnta-rPyaMtetdeircsionneA,FNBo,rOthhioC,ar1o9l7in4a State University, 1976 to present US.tS.udPyuSbelcitciHoena-lAtghenSterOvriacengCeo,mVmeetnedraantsioAdnmMiendiastlr,aNtIiHo,n,WJausnhein1g9t8o2n, DC, 1978 Chairman, Natural Exposure Study of Animals in Environmental Health Rescarch Workshop, National Research Council, National Academy of Sciences, April 1985 47 UPoSn.clPiusbtl:iScpeHaekaelrt,hCOountfsetraenndciengonSetrhveicIempMleidcaalt,ioNnIsH,ofWtahsehiBnhgotpoanl,TDrCa,ge1d9y8,5The Workers Policy Project, , NewarJke,rNsee,wMarch 1985 P`TaanscklFMoermcbeeLre,adJeAr,RCStWuodrykiofngChGeraoniucpolonTrtahcekiEnvgalAugaetinotn(oNfPtPh)e CuasrecdinboygetnhiecSRoivsiketoKfGCBh,emMiocsacloswt,o1985 Hy7manSsom-e Chemicals Used in Plastics and Elastomers, Lyon, France, June 1985 SBtouadryd DMiermebcetorr,fAomretrhiecNaTnPBMoeatrhdyolfITsooxciycaonlaotgcy,St1u0d8y3,-11998839 PPaannecll MMeemmbbeerr,, RIeAfRrCacWtoorrkyiCnegraGmriocupFiobmertAhneiEmvaalluSattuidoineso,fTtMheAC,ar1c0i8n6ogenic RiskofChemic:als to `Humaannsd-SSiloimcea Silicate, Lyon, France, June 1986 CanPcoemrelRiMsekmsber, DHHS Committee 10 Coordinate Environmental and Related Prog7ram "Report on PreAssisdoecnti,atAemderwiitchanthBeoIanrgdesotfiToonxoifcoAlsobgeys,to1s9"8,7-1198978.5 't LonPdaonne,lEMnegmlbueidr,, Health Consequences of Gecupational Exposure to Man-Made Mineral Fibers, TIMA, PanJealnuMaermybe1r9,87JARC Working Group 10 update IARC Monographs: Chemicals and Industrial Processes Asso`dCaatnecderwiinthHumans, Lyon, France, March 1087 PViucenCMheamibremra/n,RaIpApRoCraWtoeruksi,ngIXGCrSo/uMpAoRnCMTaans-kMGardoeuMpiMneeerat]inFgiboenrsMaannd-MRaeddeonM.inLeyroan], FFirbaenrcse,,LJounndeo,n1,987 EnglnSde,ptember 1987 PDainsetlinMgeumisbheerd,ANlautmionnuasl,RCeoslelaergcehoCfoVeutne]r,inBaroyarMdedoinciEnnev,iTrhoenmOehnitoalStSattuedUineisvaenrdsitTyo,wJcuonleo,gy1,988 Subcomumitiee on v Co-"CAhnaiimramlasna,sRMeovniietworosf Consultent, SAB (Drinki EofPAEnCvainrcoenrmAesnstaelssHmaeznartdGsu"i,de1l9i8n7es-,19189988-1980 ng Water Committee and Environmental Health ' Commitee , En vi ro nme ntal Protec1t0i8o8n; Agency, , ToxiMceomlboegyr,, Committee on Toxicology, National Research Counc, Board on Environmental Studies on Lec1tu0r8e6r-,1B9r9o4okings Institute, 1989 PPaunncel MMeemmbbeerr/R(aapdphoorca),teEuPrA,-FIIPFCRSA/SMcAieRnKtiTfiacsAkdGvriosourpyMPeeatni,ng1o9n89Benzene, Hannover, Germany, DecPemobnere,m1b9e9r1, EPAFIFRA Scicniific Advisory Pancl, 1992-2000 109PF2aDnAelGMreomubpeRre,coIgPnCiStTiuonskAwGarrodu,pNMietertoifnugraonnHSeyanrtihnegtiTceaOmrg,an1i9c92F.ibers, London, England, September, hePanel Member, WHO European Programme for Occupational Health, "Validity of Methods for Assessing MCehmaCbiarercmria,nno,EgPeEnAPiASc-ciFitIeyFnoRcfeA MASadcvniic-snMoiarfdiyceBAFodiavbreidrsso"Er,xyeCcPoupateinnv,heaC1go9e0mn3m,-itDteenem,ar1k9,931-0199299 48 PPaunneel MMeemmbbeerr/,REapPpAoSrcaiteenucre,AdIvPiCsSo/rMyABRoKurTda,sDkioGxrionuRpeMveieetwinCgomomnitPhtoesege(nHeea,lLtohnPdaonenl,),En1g9l9a5nd, March, `` "1996Pa.nel Member, IPCS/wMARK Task Group Meeting on Chloroetbers, London, England, March, 1996. "ToxPiacnoellogMiecmablearn,dNational Research Council, Commission on Life Sciences, Subcommittee on PanPeelrfMoermmanbceerEAPs,ApeScctisenotiffOicxyAgdevnisaotreydBMooatrodr, CVeohmiciltetFeueelso"n, E1n9v9i6ronmental Health, Ad Hoe member for PanNeelurMteomxbiecro,loEgPyAGuFiodoeldinQeusa;liCtyhParo-teTchtyiroonidAcCtarAcdivniosgoernyesBiosarGdu,id1e9l9i6nes, 1996 PMaenmebleMre,mIbLeS!r,RsEkPAScSiceinecneceInAsdtviitsutoeryWoBrokairdn,g EGPrAouPproopnosDeodseGuSiedleelcitinoens,f1or99C6arc.,inogenic Risk AssPeasnsemlenMte,mb1e9r9.7, PCS Workshop on Issues in Cancer Risk Assessment.| Hannover, Germany, January 1998 Jaannduary, 1999. :: 1999C.oChalr, EPA SAB/SAP Joint Meeting `Testing of Pesticides in Human Subjects',' Dec 1998 and Nov . 3 PCooCnhduiMre,mEbPeAr,SANaBt/iSoAnPalJRoiensteaMrecehtiCnogu`nEcnd,ocCroimnmeiDsissirounptoonrL,ifMeaSrccihen1c9e9s9,.Subcommittee on "Re!view of ` the US ` ' + InvNiatveyd'EsxEpxerptosTuersetiLmimointysofnorTMriacnhulfoarcotetuhryeldenVei,trAeuosutsraFliibaenrsS"o,li1c9i9to9r-2G0en0e0r.al, Mlbourne, Australia, Nov. 199P9a.nel Member, International Conference of the World Health Organization. "Advancing Knowledge on ModReergautloart,in2g0T0o0baSocccioetPyroodfuTcotxs"i,coOlsolgoy, "NIosrswuacy",SeFsesbirouna,ry",Th2e00V0a.lue and Ethics of Using Human Data for the Registration of Pesticides", Philadelphia, PA, March 2000. , AprilSE2001R. ss of ts oeloay Progr, ove Spiro Sessa fate, Aqui, 5, SReospspiaotnouCrh,aiLrS,IRiAsgkriAcsulsteusrsamleCnhtemMiectahlodSsa.fe"ty20A0s1seAsssbmeesntto,s WHeoarlktghrEofufpec#t1s,CAopnrfielr,e2n0c0e1'., Oakland, CA, May`M2e0m0b1e.r, Lovelace Respiratory Research Institute's "Research Programs Oversight Committee, 2002- FibeMreLmebnegrt,h.ATSDR Expert Panel on Health Effects of Asbestos and Synthetic Fibers (SVF: The Influence of! TesNteiwmoYnoyrkb,efNoYr.e2N0R-3C0/NOcAtSobCeormm20i0t2t.ee on the Use of Third Party Toxicity Research with Human Resea`rWcahshPairntgitcoinp,anDtCs.. 19 March 2003. } witMheTmabceorni,tIenatenrdnatthieonal Symposium on the Health Hazard Evaluation of Fibrous Particles Associated Mem`Abdejra,ceEntPADuAlsubtehstCoosmpMleecxh.anisms of Toxicity Workshop, Chicago, IL. 12:13 June 2003. ChaiCro,ntSaumbicnoemnmtist.tNeaetioonnEarlpAecrgaednecmyyaonfdSCcoienntciensu.o2u0s0E3x-p2o0s0u5re Guidance Levels for Selected Submarine Member, ILS! HES] Technical Committee on Agricultural Cemical Safety Assessment. 2003-2004. Editorial Boards 49 MEendviicraolnmReensteaalrcHheaClotuhncPlerlsopefcCtainveasd,a,1918935-21-9199084 Drug and Chemical Toxicology, 1986-1994 ` IFnuhnadlaamtieonntaTloxaicnodloAgpyp,li1e9d95T-oxicology, 1989-1995 . Reviewer; S`Acnineanlcse of Occupational Hygiene . . Toxicological Sciences i PapersPublished: . 1. McConnell, EE: Case for diagnosis. Yaba monkey virus.Military Medicine 1324838, 869, 1967. 21.96sM.cConnell, EE: Garner, FM. and Kirk, JH.: Hartmanellosins a bull. PathologiaVeterinaria 5:16, J3.AVMcNCAon1n5e6l:l1,97E-E2,03C,us1h9e7l0l,. 1G. and Garner, FM. Visceral leishmaniasis with ocular involvement in a dog. m4.ucMocsCaononfealls,hEeEep, VofanpoRsseinbslbeurign,fe1c8t]io.usanodriVgiann. WLAySk.,fJA:rAViecras,ecMoefd.aaAdsesnnoocc.ar4c1i9n-o1m2a,of1t97h0e, olfactory A5.ssVoca.n 4R1e:n7s6b,u1r9g7,0L.B.J., Roos, C.J. and McConnell, EE: Diverticulosisin a cow.LS.AfricanVer,Med, Ve6.t,BMoesdma,nA,ssPo.Pc.., M4c1C1o3n4n,el1l9,70EE. and Schutte, AP.: Bovine abortion ' causedbyAspergillus \sp. LS.African 7. McConnell, EE. and Tustin, R.C.: Pancreatic calculi in a cow.LA S. frVi et.c Meda ,Assn oc. 41:352, 1970. 8C.heMccmCoannbealblo,onEEP,apDieoVuorss,iAnJu.,s B(aKesrsro,n1,97P2.)A,. 1aPnrdotdoezVooso,l.V.:18I:s28o-p3o2r,a 1p9a7p1.ionins. sp. (Eimeriidac) of the p9.oisMocnCionngn.e1lAl., EfE, VrnViRoern,scMbeurdag,As1sn5.oc a4n2d:8M1i-n8n4e,,1L9A7:1. A rapid fest for the diagnosisofstrychnine D10i.geMsctCo2n2:n2e0l-l3,4,EE.1:671Foot and mouth diseasein South Africa - Report of the 1969 outbreak.AFMed,Serv. A1s1s.oMc,cCo4n2n1e8l0l,16E1E,. S1u9m7it1, 1.D. and Venter, H.J.: Melanoma in the larynx of a dog. LAS.friVecr,aMend, 12. Schutte, AP. McConnell, report. LS, African Vet. Med, EE. and Bosman, PP.: Vibrionic Assoc. 42(3):223-226, 1971. abortionin ewes in South Africa: Preliminary V1e3t.. MRceCs.onn3e8l0l2,1E17E1,2B6a,sso1n97P1.A. and Pinaar, J.G.: Pneumocystosis in a domestic goat. Onderstepoor1t. 50 {1a4c,aCroifnfae:eH,aGloMr,acVhnaindaAcs)woagnedna,nPeIwM.recMocrCdonfnreolml,hEeECaancdiBaasbsaobno,oPnA.:ZDeescrliptiiFounrsoAfnaegnoewhawnndratseailZmoioftleogtie ~ SBQKIS-190,1071. K1e5r.r,Mc1C97o2n)n.elQlndEeErs.tBeapsosoornt,1P.AV.er,anRdes.do1s8:,20V7.-:21N4a,sa1l97a1ca.riasis in the Chacma baboon (Paplo wrsinus, + f16r.omCotfhfeeel,arGyMn.geaalndveMntcrCiocnlneeslolf, tEhEe.ChPahcemuamobnaybsosouns(vPoacpiaolsurns.inspu.s,(AKcearrr)i.na:ZHleariacthnsiFducarcah)ngarneweiawnfdmtittee Zoologie 58:265-270, 1971. : w1r7s.iBnaurst,sKcehr,rR,.C1.5,72We)s.sLelulbs,AnBi.Cm.alasnd6:M4c1C-o4n7n,e1l9l7,2.EE: Myocardial tuberculomain a Chacma baboon (Papio : 7188.-M6c8C2o,nn1e9l7l2,. EE., Basson, P.A. and devVos, V.: Laryngeal icaflasis in the Chacma baboon. JAVMA 161: 3 K19r.ugMecrCoNnanteiloln,alEPEa,rkT.uLsAtSi.n,fRCr. ainVderdce,VMoeasd,,VAn.s:sAo,nct.h4r3a:x18in1a-1n87A,fr1i9c7a2n.buffalo (Syncerus caffer) inthe + : * m20u,scNleeCsomoeflclh,acEmEa.bBaabsosoonns,.PAQ. dTheormss,i5c.1p.aVonedto,dRreeVtso.s392:11o3-1c16t, 19o7f2s.osp-or Pps i the sclera 2f1r.eMrcCaonngnienlgl',CEhEa.cmBaasbsoanb,ooP.nAs.,(PWaoplisotuernshionlumse),fBr.o,dmeVtohes,KVru.gaenrdNaMtailohnearlbeP,arHk.: toxoplasmosis in TrR.a Soc.nTrosp,M.ed, Hyg. 67:851-855, 1973. t22e. dCehVaocsm,iaV.b,avbaonoKnic(kPearptl,oCu.rAsWi.hJu.s)afnrdomMctChoennKerlulg,erEENa:tiAonsaulrPvaeryok.fsKeoleedcoteed16b:a1c-t1er0i,o1lo9g7i3c.al infections of * C23o.nfMecrCeonncneeloln, EEnEv:irLoensmieonntsalfoTuoxnidcoilnogayn.ima(lAsMReLx-pToRs-e7d3:t1o2c5o)a:l1t8a9r-a1c9r8o,so1l9s7.3.Proceedings of 4th Annual f24r.eeM-craCnogninneglblabEoEo.nsBa(sPsaopni,o 1974 PurAs.induesV)ofsr,oVm. hMeyeKrsr,ugBe.Jr. NaantdioKnuanltPza,rkR.E:OnA dsuervreysoif cdIi,psVeeoars,oeRsreastm,o4n1:g971-01068, e25x.poMsaucrEewsento,h1y.Dd.r.aMzciCnoenonnelaln,imEaEl.sa.nPdroBcaece,diKn.gCs.:5tThhAenenfufaecltsCoofnf6e-rmeonnctehonchErnovniircolnomwenltevaell Tionxhiacloaltoigoyn. AMRLTR-7:4:125:225-235, 1974. . o2c6c.uHlatrrdiiss,eaAsMe.IHoarrteosne,arMc.hLc.aLneitnsechceolro,nyR.M,LaMbc.CLoanbn,eAlnli,mE.E$.ia.nd24N:e7w6,9-A7E09:, 1E9n7z4o.otic Brucella canis - an S27t.reSpttuoacrto,cdD.DL.abB.ucAkn,imG.E.Saa.nd25M:c2C0o6n-n3e0l2l,,1E07E5:. Necrotic dermatitis of mice caused by Lancefield Group G. i2n8.haMlcatNiuotnt,exNpSo.s,uArmes1t0er, R1.. McConnel, EE. and Morris, F Hepatic pathologiynmice after continuous 1.0, richloroethylene. Lab. Invest, 32:642-654, AMRLTR74-60, 1975. 51 29. Thigpen, JE. Faith, RE., McConnell, EE. and Moore, JA: Increased susceptibility to bacterial infection as a sequela of exposure to 2,3,7 8-tetrachlorodfbenzo-p-dioxin. Infect.Immun. 12:1319-1324, 1975. 30. McConnell, EE. animals. Ver, Path. a1n4d:4T3a5l-l4ey4,0,FA1.977.Intracytoplasmic hyaline globules in the adrenal medulla of laboratory 3910.3)M,cC1o9n7n7e.ll, EE. Parasitic discases observed in free-rangin;g and captive baboons.Comp,Path. Bull. 1975. , 32. McConnell, EE., Moore, J.A. and Dalgard, D.W.: Toxicity of 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) in rhesus monkeys (Macaca mulatta) following a single oral dose. Toxicol.Appl.Pharmacol. 43:175-187, `3p3r.eHlaimsisn,aJrRy.r,epMocrCto.nLnclAlg,r,EFEo.oadnCdhHeamrv.an26,:D9.4J:.9:9,Ch1e6m7i6c.al and toxicologic Pe evaluationofFiremaster BP-G: a 34. McConnell, EE., Moore, J.A., Haseman, JX. and Harris, MW.i The comparativetoxicityofchlorinated dibenzo-p-dioxins in mice and guinea pigs. ToApx pl.i Pharc mac. ol. 44:335-356, 1078s ee "3`5b.iphMecnyCl o(PnCBn)eEtElox.liciHtaysisnLrRh.esAusltmmoann,keNyHs.(aMnadcaMcoaormuel,atLtAa:):Atosxipcoonptaatnheoolougsy.oLutabbr,eAankoifm.poSlcy.chlorinated 20(5)566-673, 1979. = b3i6.phAelnnynlan(P,CNB.)H.t,oxNiceiwt,y 20051661665, 1979. iAnEr.heMscuCsonmnoenlkl,eyEsE.(MaancdacFearrmeullla,tTt.aL):: cAlinsipcoalnto'abnseerovuastio onsu .Lat bo,Afb npiomlr .ycShce li.ora inak ted 3 37. McConnell, EE., Wilson, R. and Moore, JA.: Dose responsc of 1,2-dimethylhydrazine and . `methylazoxymethanol acetate in the F344 rat.CancerLetters 8:271-278, 1980. 38. Van Logten, M.]., Gupta, BN., McConnell, EE. and Moore, JA: Role of nasystemin the action of 2.3,7,8-tetrachlorodibenzo-p-dioxin on the thymus. Toxicology 15:135-144, 1980. 39. Fowler, B.A., Kimmel, C.A., Woods, in the rat. TI. Anintegrated approach 15., McConnell, EE. and Grant, LD: to the assessmentof long-teleramd Chronic low-level lead toxicity toxicity. ToxicolAppl. "Phamacgl. 5659-77, 1980. . 40. McConnell, EE, Moore, J.A., Gupta, BN,, Rakes, A.J., Luster, M.L, Goldstein, J.A., Haseman, J. and P`Calrikneirc,oCpaEt:holTohgye. cThroonicxtAopxiipclic.tyPohofartmleaccho.nlic.a5l2a:n4d68a-n4a9l0y,ti1c9al80p.entachloropihnecanttolle. L 41. Parker, C.E. Jones, W.A., Matthews, H.B., McConnell, EE. and Hass, JR. The chronic toxicity of technical and analytical pentachlorophenol in cattle. 1. ToxApiplc .Pho arml aco.l. 55:359-369, 1980. T42a.bMic.Ree1.,MDL,iFacith,rPRo.woaenrdw1M5c(aC1)o:nv4n5e-le5l2,,E1E9:80,Effects of long-term 2450 MH2 microwave radiation on 1980, 43. McConnell, EE. Harris. MW. and Moore, J.A.: The lack ofeffectiveness of activated charcoal and cholestyramine in reducing the body burden of polybrominated biphenyls. DrugChem,Tox. 3(3):277-292, 52 414..2-Sdchiimleltehr,ylChMyd,raCzuirnlee.y,CaWnHc.eraLnedttMecrCson1n1e7l5l-,79E,E:198I0n.duction o.f colon tumors bya single oral dose of : 2453..7Bicrrnrbaacuhml,o1rDod.ibDeecnazdo,fuGrMa,n iMnattthheemwosn,kHeyB.. aTnd oMcCxonAnpieplllc.,PhEoaEr:mlaFcaa.rle.o5f7189196, 1981. ~~ 46. Gupta, BN. McConnell, EE, Harris, MW. andMoore,JA: Polybrominated biphenyl toxicosis in the rat and mouse. ToxAi pplc.Phoarmlaco.l. 57:99-118, 1981. `47p.heLnaomxby,ac1.iCd.s, iMnarckosm,biTnAa,tMicoCnownintehl2l,,3E.7E..5ATbCeDyDwiinckCr5a7mBaL,/K6.maanldeMmoiocree.,1.JTAo:x,ETnosvlicrlotny,oHfltchh,lo8r:i8n1a5t:e8d24, Iss1. t4o8x.iVciatny oLfog2t3e,n,78M-.tJ.c,irGaucphtlao,roBdNib.enMzcoC-opn-nedlilo,xiEnE.(TaCnDdD)Moion'rrea,fsJ..A.T:oxTihceoliongfylu2e1n:c7e7o:f88m,al1n9u8t1r.ition on the : , C49a.rcDiunnongiecnke,siJsX.b,ioParsejseaayn,ofJ.aDl.l,yHiassoetnhaionc,ya1nKa.te.TFhuonmdp.sAopnp,lR.ET,oxGiicloels.,2:H1D1.4-a1n2d0,M1c9C8o1n.nell, EE: o Erbi o50l.dMecnCohnanmesltle,rsE.E:NTNPTTPecThencihcniaclaRlerpeoprotrtNoo.n2t4h9e,cNaIrHcPiunbolgiecnaetsiiosnbNlooa.s8s4a-y2o0f50a,mo1s9i8t3e.asbestoins syrian. tSeLs.tKilnguwoef,pWhtMha.laMtceCoenstneerlsl,anEdE,relHautfefd, cJEo,mpHoausnedmsanb,yJtKh.e, NDToPu.glEansv,iJrFo.n,aHnedaMlotohPree,rsJpA.:45C:a1r2c0i-n1o3g2e,ni1c0i8t2y. h52a.msFteelrdsma(nM,esDoBc,icMecrCuosnnaeulrlat,uEsE).feadndvaKryniangplkeav1e,l:s oGfrporwottehink.idLraibcy,dAinsiemaasleSacnid.3l2o(ng6e)v6i1t3y-o6f1s8y,ri10a8n2g.olden `a5A3pn.pdlD.erPxehpwao,rsmuRarTce,odlBu.orao6tr8i:mo1an2n0,o-n1G3cA0a,.nc1He9ar8s3ie.nmdaunc,ti1onX,byMcaCkonnnoewlnl,caErEc.inBougsecn,InWr.atasn,dmiMcoeoraen,dJhAa:msTtehres.effTeociteoofla,ge b$i4.phGeunpytlam,iBxNt.,urMecCinonthneerlaltaEnEd.mGooulsdsei.ci1.n,SiJ-Am,oHnatrhries,xpMosWu.rea.ndTMooorex,AJpApil:.PEcfhfaeocrtmsalocf.a 6p8o:l1y-b1r8o,m1i9n8a3t.ed `5m5i.xGtuurpetai,n tBhNe.roMtcCaonndnemlolu,seE.E.1.MoLoirfee,ti1mAe. satnuddy.HaTsemoan,xJApi.p:lc.EPfhfoaerctmlsaocfo,la.pGo8l:y1b8r-o3m5i,n1a9t8e3d.biphenyl . p$r6o.cMecdCuornense.lTlo,xEicEo:l PPaatthhoollo.g1y1(r1e1q6u0i-r6e4m,en1t9s83in. rodent carcinogenesis studi. I. Arev, iew of current T5o7x.icMoclC.oPnantehloll,.E1E1:0):P6a5t-h7o6l,og1y98r3e.quirements in rodent carcinogenesis studies. Tl. Alternative approach. g5o8.ldMecnCohnanmesltle,rsE.E;NTNPTTPecThecnhinciaclaRlerpeoprotrt249o)n, t1h9e83c.arcinogenesis bioassay of chrysotile asbestos in syrian a59m.osMictCeonanseblels,toEsEa.nRdutttreer,moHlAitienUlFl3a4nd4.rBatMs.. EannndiMoono,rHee,alJ.tAh.:PeCrhsrpo.ni5c3:e2f7f-e4c4ts, o1f98d3i.tary exposure fo a60m.osMictCeonannedllc,hrEyEso.tiSlheefansebre,stAoMs.inRsuysrti,an1Hg.oladnednMhoaomrset,erJsA.:ECnhvriornoin,c HeefafletchtsPoefrsdpi.e,ta5r3y:1e1x-p2o5s,u1r9e8f3o. 53 + Ga1n.dSnoelolepvlealsdt,aHiAn ,theHaFsicscmhaenr,3I4X4./aNnrdotM.c.CoNnantell,lC,aEnEce:rITnhset.na7t2u)ra:l92h9is-t0o4r0y,of19b8o4d.y weight gata, survival 6s2t.ruMcctuKrien-nteoxyi,ciJt.Dy.,reClhaatei,onKs.h,iMpcsCfoonrnepollly,cLhEl.orainnadteBdirbnibpahuemn,ylLsSg:ndStrreulcatteudrea-rionmdautctiicohnyvderroscuasrbons. Environ,Health Persp. 1984 6e3x.peSroilmleevnetladl, Ho.nAc.ogaennedsMicsC.oTnonseilclo,lEPEa:thoTlh,e7s2i:g9n2i9f-ic9a4n0c,e1o9f8i4n.terim sacrifice and lifespandatain . D64i.oxMicnCoinnnseolill:, BEiEoa,vaLiulcaibeirl,itGyWa.f,teRruimnbgaesutgiho,n bR.yC.r,atAslbarnod, Pg-uWi.n,eHaaprivgasn.,SDc.iJe,ncHeas2s2,3J:R1.07a7n-d10H7a9r,ri1s,98M4..W.: 65. Dunnick, JX., Davis, W.E, Jorgenson, T.A. Rosen, V.J, und McConnell, EE: Subehrohic toxicity in rats administered oral 8-methoxypsoralen.Natl, CancerInst,Monogr. 66:91-95, 1984. * + TG6w.o-HyaesacramCaanr,ciJpXo.,geCnriacwiftoyrSdt,udDi.eD.s CHounfdfu,cJtEe,dBaototrhmeaNna,tiGo.An.a,laTnodxiMccoCloognynePlrlogErEam:.R1,eTsuolxt,sEqfvriormon8.6Healt* h 14:621-639, 1984. 0H7i.stHoupfaft,hJoEl.ogByatRces-,cxR.amiEunsattiis,on5.ofHathseemNaanti,o1naDl.CaanndceMrcICnosntnietultle,'sEECa.rcMianloagtehnieosniasnSdtuMdaielsa.oEsnovni:ron,Res. 37154173, 1985. EGn8v.irMocnC,oHnenaellt,hPEeEr:spC.om6p0a2r0a-t3i3v,e1T9o8x5i.city of PCB's and Related Compounds in Various Species of Animals. GROe.suHlutfsf,inJ.C0a.r,cMicnCoognenneilcilt,yESEt.u,dainesd iHnaAsneimmaanl,s.JKE:nviLertotnemretnotatlheMuEtdaitgoernoensitshe7:P4r2o7p-o4r2t8i,on19o8f5.Positive | T70e.rmSiolnlaetvieolnd,DHa.tAa.,inanLdonMgcCtoenrnmelTlo,xiEc.iEt.:y Tanhde VCaarlcuienaongednSeisginsifSitcuadniecse.oTfoLxi,fePSaptah.na13d12S8c-h1e3d4u,le19d85. C7O1ab.nsceHerarvseedImnasitnni,tUunJttKe.r7,e5a(Ht5ue1fdf:,9a7Jn5Ed-,9C8R4oa,mo1,9OG8i.5lN..G,avAamgoeldC,onJtEr,olBGoroorumapns,ofG.FA.3,44a/nNd RMactCsonannedllB,6ECE3:FLNMeiocpel,aLsmNsa 7St2u.dMicesC)o.nnNeTlPl,TeEcEh:niTcoaxliRceoploorgty Naon.d2C0a5r,ci1n9o8g5e.nesis Studis of Chrysotile AsbestosinF344/N Rats (Feed 7o3f.CMacrcCionnongeelnli,ciEtEy,inSoLlolenvge-ltde,rHmAT.oxaicnidtyBoaonrdmaCnar,cGi.nAo.g:enGeusiidselSitnuedsiefso.r1CoNamtbli,nCianngcNeeroIpnsltaisrmusteas Evidence TG2:283:289, 1986. N74o.meMnacrloantpuorre, RfoRr.,HeMpoanttopgroomleirfeyraJtri,vCe.LAe.siBoonosrmofanR,atGs..A.T,oxM,cCPoatnhn. ell1,4:E2E63:-2N7a3t,io1n9a8l6.Toxicology Program T75u.nHoarseInmcaind,enJcKe.AnHaarlryisnegsiofonr, 8E1C,ReHcuefnft, JNEat,ioMncaClonTnoexlilc,olEoEgy:PCroomgpraamriCsaorncoinfoSgietnei-cSipteyciSftiucdaiensd. ORveergaulllatory Toxicol,Pharmacol 6:155-170, 1986. 54 G76A..McRCiochntneer,llC:EET,heBuTcohxeirc,iJtyRo.fSMcehtwheytlz,IsBo.cAy.anGautpet.aE,nvBiNr.onS.hSeclibye,ncMeTDe,chLnuostle,r,21M:.18B8r-o1d6y3,,A1R98.6.Boorman, +F7i7s.chMecrCo3n4n4e/lNl,raEtEs:anNdTBPGTCe3cFhLnimcialcexc(pgoarvtagoenstthuedyc)a.rcNiTnPogTeenccshinsicbailoRaespsoarytofNod.ig2l5y7c,idy1l98r6e.sorcinol ether in T7o8.xiBcuicthyoerf,MJeRt,hySlchIwseorczy,anBa.tAe,CSohneflebrye,ncM.eD..EnMvciCroonnn,elHela,lEthEP:erIsnpt.ro7d2u3ct,i1o9n8t7o.the Proceedings of the E7n9.viMrcoCnomnennetlall, aEnEd,Roeflaal.te(dPPrerpoagrreadmsb,ySauWbocrokmimnigttGereouopn fRoirskthAessDeHsHsmSenCto)m:miRtetpeoerttoonCoCoarndcienratReisks `Associated with the Ingestion of Asbestos. Environ,Health Porsp, 72:253-265, 1987. 80. McConnell, EE: Letter to the Editor on Cancer Phobia. Seience 238:59-60, 1987. 8C1a.rcHiansocgaennainci,tJyXS.t,uHdiuefsf.,|EEn,niZreoing;erH,eaEl.tMhcPCeornsnpe.ll7,4:E2E2:0-2C3o5m,pa10r8a7t.ive Results of 327 Chemical :g W82,. HHaurftf,, LJEG,,MRcaCllo,nDn.ePl:l,Car.ciHnoagseenemsains,St1uX.d,iBeos:orRmeasunl,tGso.Af.,3E9u8steisx,peSrLi,mSecnhtwseotnz,10B.4A.c,hReamoi,caGlNsf..rJoammtehseon, US. National Toxicology Program. inLCivihneien o micaWorlld. An N.Y.a Acad.lSci, 5341-30, 1988." 8ca3r.cHioncolg,enDi.cGi.t,yHsatsuedmian:,imJ.pXl.i,cHaotgioanns, fMo.rD.r,isHkuafsfs,esJ.,sMmceCnotn.neClalr,ciEnEo:genTehseisim9p:a2c0t45o-f2t0o5x2i,ci1t9y8o8n. 8344.4M/cNCorantnsel(lfe,eEdEs:tudNy)T.PNTTecPhTneicchalnirceaplorRtepoonrtthNeoc.ar3c3i5n,og1e9n8e8s.is bioassay of crocidolite asbestos in Fischer 8153.BMuetlandiicke,neRLb,y Hthue,NaJtiEo,naHlasToexmiacno,loJg.y..PMrcoCgornanme.lAlt,mE,EN:.YC.hArcoandi,cSfcoiseinicteysre5s3u4l:t6s4a8n-Gd6o2n,g1o9i8n6g.studies of 86. McConnell, EE: The maximun tolerated dose: The debate. 1 Am,Coll.Toxicol, 6:1115-1120, 1989. 8ra7t.sMfceCeondnestluld,y)E. E:NTNPTTPecThencihcnailcaRleproerptorNtoo.n27t7h.e cMaarrccihno1g9e9n0e.sis bioassay of remolite in Fischer 344/N F8i8s.cMhuerrtFh3y4,4A/SniK.n,rMatcsCionmdncBlG,CE3E.FHmuifcfe, eJxEp.oRsuesdsftioelddi,glAycBi.dyalnrdesGoorocdi,noAlEe:theFro-rAesnteopmoaxcyh rneesoinp.laFsomosdin" Chem,Toxic, 28:723-729, 1990. 8g9o.ldMecnCohnanmesltle,rEsE(.feNedTPstTudeyc)h.niNcTalPRTeepcohrnticoaln RtehpeocratrcNion.og2e4n6e,sJiuslybi1o9a9s0s.ay of chrysotile asbestos fn Syrian 9304.4M/cNCroantnsel(lfe,edEEs:tudNy)T.P TNeTcPhnTieccahlnirceaplorRtepoonrtr.heNoc.ar2c7i9n,ogNeonevseimsbbeiroa1s9s9a0y. of amosite asbestos in Fischer 91. McConnell, EE. Hall,L and Adkins, B.A. Studies on the toxicity (inhalation) of wollastonite in Fischer 344 rats. InhalationToxicol, 3:323-337, 1991. 9129.91M.cConnell, EE: NTP Carcinogens -Intrerpretational Problems.Envizon,Mutagenesis, 248:233-237, 55 9s3t.udMiccCsoonfnetlwlo, gErEa.deHsulolf.pJeEn,taHcohjliomraonpchiekn,olM.inPBeOteCr3sF,1A.mC.icea.ndFuPnerds.iAnpg,plR.:ToTxoixcioclo.lo1g7y:a5n19d-5c3a2r,ci1n0o6g1e.ncsis "94He.avlipdIeebrnricaneh,ioWmn,EtM,hAeM.chCuoBmnoanncdnl,lcG,arGEc.iEn,oBguMerunkniecr,ioTt,.yA1o,f.C2o,Sl4we-e,Dn.%bE.enrDvgoi,srtoJ,nA.EH.NeZa,altEtinhnt,ePreSlHirn.se,,anP9dE6,:G2rG1a3oh-au2m2g.2h,JM,:1.0WG9er1ie.gehntbeorfgt,HReS. 9s5t.udMiceCsocnonneldlu,ctEeEd:bTyhythreoiNdCIf/olNlTiPcu.lRaergc.lTlocxairccoiln,oPgehnaersmi,s:1R6e:s1u7l7t-s1f8r8,om1939423. two-year carcinogenicity i9n6.haHloesdteprobleyrpgr,opT-yWl.e,neMcbCeornnseliln,raEtEs..FuMinldle.rA,pWp.)C..T,oHxoimciollt,on1,9:R.35a8n-d36B6u,n1n9,9W2..5. Pulmonary tokiclty of a97n.dHAensdteerrsbeorng,, RT. WCh.roMnililcleir,nhWa.lCat,ioMncCtooxnincietlyloEfEs,izCeh-esveapalreart,e1d,gHlaadsslefyi,beJr,s BienrFnistsecihne,r D34M4,raTthse.vFeunnadz.,APp.pl. Toxicol, 20:464-76. 1993. ' *. P9eu8xb.pleiMrcciaCmtoeinnonntesal,llV,abnLEi.mEa.1l2sa7.n:dI3nS2w3Be-ue3tn3ba3ed,rig1c,9n19.3a4.n.dStSytryerneenea:nAdsssteysrsemnecnotxiodfe:HeRaelstuhltHsazoafrsdtsu,diIeAsRoCnScciaernctiinfoigcenicity in R9a9t.hMoclCoognyn,e2l2l:,14E1E-.14a4n,d E1u9s9t4i.s, S.A. Peer review in carcinogenicity bioassays - Uses/abuse3s. Toxicologic 100. Lucas Luijekx. N.B. Rao, r2e0l9a6t-ed10t4o,ag19e9i4n. long-term to GN. xicity McConnell, EE, Wurtzen, G: studies - Considerations for and risk Kroes, R The intake of chemicals assessment. Reg.Toxicol.Pharmoc ol ,, 10T3h41e4.v/eNMnrcaaCzto,sn.nPe.lIClnhh,raloEanEti.icoKnianTmhosaxtliractuoiplo,,n60s:.t5u7Md1uy-so6sf1cs4li,mz1ae0-n9s,4eR,p.a,rHaetsetderrboecrkg,anTd:Ws.iaCghwevoaollieirn,suJl,aM.tiilolnefri,beWr.sC.i.nanFidscher Ri1e0nl2ha.atHlieoasnttsiehiorinbpebrraegtt,s.wTeEWenn.vilrMuionlngl.ebHril,otsWhp.,ePrCes,rissMpta,esntc,1e0R2.a,1n1Md3cb3Cio1on3ln7oeg,licl1a,9l9E4eE.ff,ecBtesrnosftemiann,-DmMa.deanvidtAtnedouesrsfoinbe,rsR.after chronic 510334./M1c9C4o.nnell, EE. Synthetic vitreous fibers - Inhalation studies. `Reg.Toxicol,Pharmosal. 20 2)522- i11n004h2.a:l2Ma0at7is-ot2n,1a0R,n3Wd.1,b99iH4oe,psetresribsetregn,ceTWo,f reGflraascst,orLyR.c,eMrcaCmoincnfeilble,r iEnEr,atAsndaenrdshoanm,sRt.erasn.dEnBveirnrsotne.iHne,aDlMth.PCehrrsopn,ic P10h5a.moMccoColn,ne2l1l3,8-E4E3,Hi1s9t9o5r.ical review of the rodent bioassay and future directions.Reg.Toxicol, GS1ly0a6r.sisa,MncLgCRoo.lndnaeennldlh,aAmnEsdLte.errsMsoa.nsI,tn,hR.aRlWCa.htriooHnneTisoctxeiirncbhoealrlag.t,7iT:o.n5W0.t3,o5xCi3ch2iet,vya1lo9ife9r5a,.kJa,olKiontibna,sPe.,dBreerfnrsatcetionr,yDcMer.amTihcefviebnearz(,RCP.F,) in 56 L10R7.. MMaislte,r,RIWW..C,.MacnCodnnHeesltle,rbEeEr,g,ATndYe.rsSotnu,diRe.s, Cohnavtahleiecrh,roJ.n,iKcottiosni,ciPt,yBGenrbnasltaetiino,nD)Mof,fTohuervteynpaezs,oPf. Glass, 5 ** refractory ceramic fiberfn male Fischer 344 rats.Inhalation Toxicol, 7:425-467, 1995. G1l0a8s.s,MaLsRt,, RMWi.l,leM,cCWo.nnaenldl,AnEdEe,rsHoens,teRr.bAermg,ulTfWi.p,e Cdhoesvealciehrr,onJi,cKionthianl,aPti.oTnhteovxiecaitsy,sPt,aBdeyronfstseiizne,-sDeMpa.rated kaolin refractory ceramic fiber (RCF) in male Fischer 344 rats.InhalationToxicol. 7:469-502, 1995. 110999.5.McConnelElE., Advantages and linsrarions of in vivo screening tests. Ann,Occup,Hyg, 39:727-735, q1u1a0r.tMzc.COocncnuepl,lE,nEvEi.roFni.bMroegde,nic52o:f6f2ec1t:6o2f4w,ol1l9a9s5t.onite compared with as.bestos dust and dusts containing ris 1o1fv1i.eMwc.CIonnhnaellalt,ioEnET.oxTihceoml,a8 (iSumpplt)o:l1e1r1u-r1e2d3,do1s9e96i.n particule inhalation studies:Apathologist's point. ; Kr1ea1f2mr.sactMtrcouCrpyo,,nnc0ee,lrlaa,mniEdcEf.Hi,obdeHlreessyit,enrJb.reoRrdeges,nutlTst..sW1o.fOCbchfeccvu-aptlaiitme,re,HieJna,hlaTtlhhaetSivaoefnnearszyr,:uAPdu,isstKoroaftliginl,aaasPns,,dMmNaisentew,rRZg.e],aaMlnuadsnsds,ella1gm2aw:n3o,2o7Rl-.s,33a2n,d~+ ~ * 1996. . ` (1OM1b3eT.rDd)Hoerfssottreerarb,feirGb.ge,rUTsl-eaWs.os,fMclchuCrnoognntinocexliilcn,ihtaEylEaa,tnidoMniJslutenurgd,pyWair.tCni.c,tlheCehcerlvaea.alFriaeurnn,cdeJ,.f,AoEpvpeeslrt,iiTtmotax,tiecJ, oTtlhh,eev3me2an3xa1iz-s,4m4Pu.,,mF1tl9eo9il6se.srnaetre,dHd.oasned Cf1ho1al4s.deeH,nesGh.taRem.rs,bteaernrgd:,TTThwWeevl.evneAaxmzto,ennP,t. hCC,hprrMoecnlCiiocmnininneahlralyl,arteEisEuol,ntssO.tbueSdridyxotorhfsItfnebtrce,rrgnGal.taisEosvn.eaarlnitdC,osnJrf,aeoMsriieltneecrea,soWbn.e,NsaCthtueovrisnaalltihaeren,dSJy.MriIaa.nn `1m0a5d:e12F2i3b-r1o2u2s9a0n,d1N9o97n.-ibrous particles, Lake Placid, N.Y. 15-19 Sept 199.Environ.HealthPersp, MS1p1Jr5..ogMTuoacfyt-e,DsaJ,vDBl.eAyS.iRnMagcteCsro,onAfnJetWlh.le,,PBoErlEoy,wcnhN,leoaJrlFi.,nBaJ.rt.He.d,MeBBnirptuhnoennne,yrlR, 1.Mi,xatnHudarmeMisolotAroreon,c,lJoSA.r5.s.C1So0um1l6pl,aivr1aa2nt4Ti2.v.Me,1C2aP5er4rctieanrnosgg,eA1n.2iC6c,0i,,tyRyuann, Tosicol Sd 41/6276, 1998. , O(1b1M6eT.rDd)Hoerfssottreerarb,feirGbg.e,rUTsg:leWa.sosf MlcchuCrnoognntinocexliilcw,ihtaEylEaat.nidoMnilluslntegru,dpyWa.rCit.ni,ctlheCehcerlvaera.alriFaeurnn,cdeJ..tAoEuvepeslrt.iitTm,oaxtJi.e,cTotlhhe,ev3me2an3va1iz-s,4m4Pu,,nF1te0oi9ls6es.rnaetre,d Hd.oasend Pt1.h1e7a.nSdyHreOisbatenerrgdbooelrrdsyei,neTrh,Wa.Gm,.stASexrtt.eunPd,airCt.,o1n.McRtCehosenunilenthlsallo,afEtaEi.os,nuHtbaocrxhtir,coonGli.oAcg.y,stMouifdltylwerao,nfdWib.deorCsgheleavssaseleicsetrai,noJdn, afEmovfoseoirtcehtrJ,a.ocnbTiehcsestvtoeusndayizn., Inbal.Toxicol 11:747-78.4, 1999. Ga1sR1b8..e,sMTtchoCesovinennnteohzlelaSEnyErd.i,aKnoAtxgitone,lndP,e.nCS,htaHumedssitteeesrr.obenPratgrh,teT2i..nWhRa,elsCauhtleitvosanloitfeorcx,hicrJoo,lnoMigicylleeoxrfp,otsWwuo,reiE.bvIeenrribgtaltla,,sJTs,oexsOibcaeonrlddoar1m1s4ot7es8ri5,t.eG8.36C,hase, 1999. 57 119. McConnell, E.E. and Carbone, M. A comparison of pleural mesotheliomas indbu yac sbeestdos and SV40 virus in Syrian golden hamsters.InhalationToxicol. 12:173-181, 2000. "12T0ox.icMoclC.Ponhnaemlalc,oElE,.3A2:s1c4i-e2n1c,e-2b0a0s0e.d paradigm for the classification of synthetic vitreoi us fibersR.eg. 121. Mast, RW., Yu, C., Oberdorster, G. McConnell, EE., and Utell, MJ. A retrospective review of the caasrsceisnsogmeennitciotfytohfe rMeTgrDacatnodryicmeplriacmaitcifoinbserfiornrtiswkoacshsreosnsimceFnits.cIhnehra3la4t4iornatToixnihcaolalt,i1o2n:s1t1u4d1i-es1:17A2n, 2000. Toxicol, 53:377-391, 2000 122. Freeman, G.B., Singer, A.W., Lordo, R.A. Peters, A.C., Neal, B.H., McConnell, EE.,andMayes, B.A. Chronic Neurotoxicity of Aroclor Mixtures Administered in Digt toSprague-DawleyRats.Fund.Appl. 123. Kamstrup, O., Ellenhauge, A., Chevalier, J., Davis, JMG. McConnell, EEandTheveflazP,. Chronic inhalation studies of two types of stone wool fibers inrats. InhalationToxicol, 13:603-622, 2001. . v1i24t.rcMouasxifmib,erLsD;.AawnodigMhctC-oonf-ntehlel-,cvEiEd.enIcnetearpsppercoiaecsh.cRoemgpa.rTioxsiocnoslo,Pfhtahremtaocxoicli,ty33o1f1-a2s4b,es2t0o0s1,and~ synthetic 125. McConnell, 15812001. EE. The valueof human testingofpesticides. HEumcan aondlogiRisckAsasesls. % 71575- 126. McConnell, EE. and J.M.G. Davis. Quantification of fibrosis in the lungsofrats using amorphometric `method. InhalationToxicol. 14:101-110, 2002. PapersinPreparation/Submitted/AccentedInPress: . `GWreaiyg,htGMo.f thCeoheevni,de)n.cT.e, Cevuanlhuaa,tiGo.n, Hofuglhoews-,doCs.,e MrceCpornondeulclt,ivEeEa.ndRhdoemvbeelro,pmLe.,nStiaplese,ffLeGc.tsaonfdBMiastphteinsoolnDA,.. 11.0M5c6C-o1n9n6e5ll(,ThEeEs:i-sA10s6t5u)d.y of 76 canine hemangiosarcomas recorded at Michigan State University from 2 McConnell, EE: Yaba virus tumors. NatjonalCancerInstituteMonograph 32:239-224, 1969. 73.43D6i.a37m,on1d97,3.$5. and McConnell, EE. Veterinary pathology in toxicology research.AFMed,Svc,Dig. 4. Bartsch, R.C., McConnell, EE., Imes, G.D. and Schmidr, JM.: wild and domestic animals and man. Ver. Pathol. 14:314-324, A review 1977. of exertional rhabdomyolysis in 1675. 5. McConnell, EE. and Moore, TCDD. Milano, Italy, October J.A: 1976, The toxicopathology of TCDD. In: F. Chapter 13, pp. 137-141. Spectrum Cattabeni(ed.)Proc.Workshopon Publications, Holliswood, NY, 6A.caMdc.CoSncn.el3l2,00E1E.38a1n5d0,Mo19o7r9,e, J.A.: Toxicopathology characteristics of the halogenated aromatics. Ann.NY 58  d7.ibMeonozroef,urJaAn,s.McA Connn eNlyl,AncEaEd...SDcail.ga3r2d0,:1D5.1W-.1a63n,d1H9a7r9ri.s, A.W. Comparative toxicity of halogenated . a`8n.mudMtcRaCegoelnnanetseeildsl.C,oEImnEp::oRu.AncKduistm.ebraEonlusdegcvhiher(roendNi.ocHrtutohlxoiHceoilntlyaa,tnceda,drBcpipin.pohg1ee0nn9e-ys1li3,s0T,,erre1pp9hr8eo0n.duycltsi,oNna,phttehraatloegneense,sDiisbaenndzodioxins. F9r.eiM,cKE.inMneeriya,nJ,.`F.anPdocMcchCioanrn,eleld,s.E)EC:hloSrtirnucattuerdaDl ispeocinficaintdy RaenldattheeddCiooxmipnoreucnepdtso-rI,mpIna:ct0.onHutthziesiger, RW. Environment. Pergemon Press, New York, pp. 367-381, 1962. . 2 10. Huff, JE, Haseman, J. McConnell .E. and Moore, JA: The National Toxicology Program, toxicology SdEaaftoarvvcvalauatilon tuoecfhDnariquugetssaanniddChtehomeilcoannlgs-.terTmowcaarSctiantoegeUnnievseirssibtiyo,asAsaym. eP14,srJa,noe c 19o8e 1f.teheSdymipon siugmosn. . : aLnL.dMccaCrocninneolgle,niEcEc.ifeWcatgsneorf,UJI.CCC. SCkaindamdoiraen,cJhWry.soatnidleMBooarseb,esLtAo:s aAncdogmlpaasrsatmiicvreosftiubrdeyoOfM t1h0e0)f.iJbrogenic -+ | BiologicalEffectsofMan-madeMineralFibres. World Health Organization, 1984, pp. 234-252. . . H1y2.drMoccCaornbnoenlsl., ENEat:ioCnoamlpIanrsatittiuvtee toofxiEcnivtiyroofnmPeCnBtsalanHdearletlhatSecdicenocemspaonudnFdiinsnlavnadr:io1u9s84s.pecies of animals. d123i2.b5e-Mn2cz3Co0o-,npn-1ed9il8ol5s,.iEn.E:In:ThMe.cKlaimnircionpa(tehdo)loDgic ichainongteshxeinEnvivairrioonunsmessnptec.ieHseomfisapnihmearlesPcuabulissehdibnyg Corp, pp. BiM1o4.loMegciCcoacnlnelhl, EaE:nCloifiniDcioospxaithnmoAlcotgsiiocnC.onpcpep2t7-s37o,f D1i9b8e4n.zo-p-dioxin Intoxication. In: BanburyReport18: C1a5.rcMicnCoognenneelsli,s ETEes:tiInsgsauensd REaviasleuadtiboyn.theInN:aPtrioocnaeledTionxgiscoolfo1g5ytPhrCoognrfaemrAedncHeoocn EPannveilroonnmCehnetmailcTaolxicology `OOhcitoo,beAr30F.31A,TaRnM8d4N-o0R0v2e,mLpbepr1J3,61-918443., 1U9n8i5v.ersity of California, Irvine, Wright-Patterson Air Force Base, Q1u6.alBiotoyramsasnu,raGn.Ac.e iMnopnattghoomleogryy,foCr.Ar.o,dJern.tEcuasrtciis,noSg.eLn,icWiotlyfes,tuMdJi.cs.McICno:nnHella , EEn.oafndCdaHracbridniosotgye,nJo TEe:stking (HA. Milman and EX. Weisburger, eds), pp. 345-357, 1985. Qu17a.liMtcyCoonfnTeolxli,cEoElo:gyQSutauldiityesa.ndPrtihneceNtaotnioSncailenTtoifxiiccPoulbolgiyshPirnoggrCaom.,.IInnc:.Mpapna9g-1i2n,g1C5o86n.ductand Data R1.8:. MToexninccoalro,gi1c, aMnadroCnaprocti,noRg.e,nBiocoErfmfaenc,tsGo.,fBIunhsasl,ed,TeHturfafc,hlJorHoaestchaynlaenn,eJi,n MRcaCtosnannedllM,icEe..RaPgraonc,eeH.d,inMgisleorf, tSchieeantche IPnutbelrinsahteirosnaB.lV.Co(nBgiroemsesdiocnalToDixviicsoiloong)y,,pIpn:20N1e-w21C0o,n1c9e5p6t.s ind Developments in Tosicology, Eeevier TD19or.xuigHcsuoflfio,ngdyJC,DhaetHmaoiscEaevlmasla,una,LtiiJy.oo.nd.,TMeWccECho,nninqeedu.le,lsH,,eEamEnid,spLahonendrgeM-oTPoeurrbeml,iCs1haAir:ncginTCohogemenpNeaasntiyiso,nSatWluadsTiheoisx.nigctoIonl:no,SgyafDPe.rCt.oy,gErv4aa8ml7,uaptagieosn,of 1986. 59 + M2c0.CoLnenmeelnl,, RE,E,BeMcekiinnhga,rGd.rC.,, T.C,aMnitlolre,tKe,, JCRh.,erPnaetre,l,J.Y..,. SCoonridclhe-,mEu.l,lGirno,tCh.,aD.n,dKTelolerl,lC.e, LfLy.bsaRroegpenorr,,tJ.on Cancer Risks Associated with the ingestion of Asbestos.Entiron,HoalthPersp, 72:253-263, 1987. C21i..HuHfafr,iJ,EL,GM.cCaonndneRlalll,, DEPE:, KaCsarecmianno,geJnXe.s,iBsoSotrumdaincs,RGe.sAu.,ltEsusotfis3,98SLE,xpSecrhiwmeetnzt,sBo.nA,1R0a4o,ChGeNmi,caJlasmefsroonm, tChheemUiSc.alNaWtoirolnda,l"TNo.xYi.coAlcoagd.y PScri.ogr5a3m4. P1r-3o0c,ee1d0i8n8g.softheCollogiumRamazziniConferenceon "Livingina 22. McConnell, EE: Mouse SpeciesComparisons, Alan Rl.ivLeirsst,umInocr.s,:Ntehwe Yporrokb,leNmY., I1n-:3,Mo19u9s0.eLiverCarcinogenesis:Mechinisms and 2Pr3e.ssE,lweNlel,wMYRo.rk,anNdY,Mc1C0o9n0n.cll, EE: Small and large intestine. In: PatohftohelFisoche-grRayt,Academic `24m.anH-emstaedrebefrigbe,rTcWa.rc,inVoug.enV.e,siMsc.CoInn:neCellll,ulEaEr.,aBnudnMno,leWcBu.laarnAdspAfeicdtesrosofnF.iRb.e:rUCsaerocfinaongiemnaclsmiosd,edlss.Bt.o study + Brinkley. J. Lecmer and C. Harris. Banbury Report, 183-205, 1990. 25. Hesterbrg, TW., Mast, Chronic inhalation toxicity R., of McConnell EE. Chevalier, J, Bernstein, D.M., Bunn, WB.and Anderson, R. refractory coramic fibers in Syrian hamsters. ProceoefIdnteirnnatigonsal `M Worke shopocn han ofFii breCas rcinm ogenes sis, Albuquerque, NM, Oct. 1990. T2o6x.iAcnoliomgayl,sNaastiSoennatlinReelsseoafrcEhnvCioruonncmieln,tNaaltiHoenaallthAcHaazdaermdsy.PrBeosasr,d1o99n1E.nvironmental Studios and 2a7n.d BTealy,loRrH, ,K.FCe.iRgelveyi,ewCsE,ofGthielUdeSn.,AMrEm,y HEanlvpierroinn,meWn.t,aHlaHrryigsi,cEn.,eKAigmemnecly,TCo.xAi,coKloodgeyllD,ivRiLs,ioMn,cCCoonmnmelilt,teEeE. on Toxicology, National Research Council National Academy Press, 1991. 2P8r.ovGiodveeUrnncmeerntatinAcPcrooutencttiinogn.OfGfAicOe/.PEReMpDr-o0d2u-c3t,ivWeasahnidnDgetvoenl,oDp.mCe.nOtcatlobTeorxi,c1a9n9t1s:. Regulatory Actions 2e9s.poMscuCroen.neInl:lS,imEiEla.riCtoimespaarnadtiDivfefreersepnocnesseBseitnwceaernciCnhoiglednreesniasbnidoaAsduslatyss:aIsmpalifcuantcitoinosnfoofraRgieskatAfsisrsetssment, Eds. PS. Guzelian, C.J. Henry and 5.5. Olin, ILSI Press, 1992 f3u0n.cMtciCoonnonfelalg,eEaEt.fiErtsthyelxenpcotshiuoruerheo.a: S(iEnTyUl)a:riCtoimespaarnadtivDeifrfeersepnocensseinBertowedeennt carcinogenesis stu%dies as a ImplifocrRiasktAsiseossmnenst, Eds. PS. Guzelian, C.J. Henry and S.5. Olin, LSI Press, 1992. O31c.cuVpalaitdiiotynaolf MHeeatlhtohd,sWoforrldAsHseeaslstihngOrtghaeniCzaartciionnog,eCnoicpietnyhaogfeMna,nD-emnamdaerkFi,beMras.yE1u9r9o2p.ean Programme for R3e2.laHteisotnesrhbieprgb,eTe:We. nMJcuCnognnbeilolp,erEsiEs,teMniclelearn, dW.bCio.lHogaidclaely,efJf.eG.c,tsBoefrnmsateni-n,maD.dMe.,viMtarseto,usR.fainbrdesAnadfteerrscohnr,onRi.c inhalation fn rodents. Lyon, France, Sept. 1992. R3.3.CHhersotneircbeIrngha,lTatAio.n MTcoxCiocninteyllo,f FEiEb,roMuisllGelra,sWs.Ci.n,RHatasd.lePyr,ocJe.Ge,diBnegrsnsotfeitnh,eDEMi,gh,tBhuInnnt,erWn.aBt.ioannaldCAonndfeerrseonnc,e on Lung Diseases, Prague, Czechoslovakia, Sept. 1992. 50 ++ R34W..M,cMClceClolnanne,llR,O,E.MEi.lalnedr,RFeJi,nhHaersdt,erCbFe.rg,ApTpWr.,oaWcahrehseltor,EvDaSl.uaBruinngn,thWeSTo.xiKcaintey,aAnBd,CaLridpipnomgaennni,ciMt.y oMfast, + TMoaxnic-oMla,dPehFairbmer,s:16S3u3n2u1n3a6r4y,o1f9a92W.orkshop Held November 11-13, 1991, Durham, North Carolina. RRe og, C35h.emSielceacltSeadfeStyyn,tWheotrilcdOrHgeaanlitch FOirbgraensi,zEatnivoinr,on1m9e9n3t.al Health Criteria #151, International Programme on e3f6f.eMctcsCoonfncehlrly,soEtEil.e Cahnedvalcireorc,idHolJi,teHaessbteesrtboersgi,nTr.aWt.s,aHfatdelreiyn,h1alGa.tiaonndeMxapsots,urReWf.orC2o4mpmaornitshosn.Ionf:Tthoet,icand CarcinogenicEffectsofSolidParticlesintheRespiratoryTract ILS! Press, Washington, DC., 1994. 37. Wagner, BM.Burt, B.A, Cantor, KP. KrewskDi., Levy, SM. McCotinell,EE,andWhitford, GM.Health EfPfreescst,so19f9I3n.gestedFluoride, Committee on Toxicology, National Research Council, National Academy : 3 "3I8n.haHleastitoenrbTeoxri,cMiitlyloefr,MWa.nC-.m,aMdceCoVmintreclo,usEEF,ibBeerrsn:sRteeliant,ioDn.sMh.ipTthoevLeunnagz,BuP.rdaenndaAnnddeLrusnogn,ReR.tenCthiaoonn.icIn: ' 1T9o9s4i.candCarcinogenicEffectsofSolidParticlesintheRespiratory"Tract, ILS1 Press, Washington, DCx ! HeP39a.leMtchCErofnfnemecltlseo, fEtE,hGreraveis, Ln, K-immIel,mC.ApA.r,mrKyodBeealtlr,glRc-LnD,reKasoslUltnerifLeorMmdesd,inCsokmy,itMt.eaendonWoTlovxeinc-oGlaorgrye,t, A. National Research Council, National Academy Press, 1594. Cr40i.tMRcCeovnTnoelxli,coElE,.2a4n5d4S9t5e5n3b,er1g9,9J4..A. Review of Styrene and Styren>e Oxide: Long-term Animal Studics. e41x.peMrctCsonatnetlhle,hEeEa.r,inRgesopnomnasen-fmoatdheesmeisnaernadlqubersetsi,onBsersluinbm9i/t1t0edDebcyeFmebdeerra1l9H9e3a.lEtxhcOefrfpitceinto the invited MKedrizeenVehrl,sMudgcuhreocn,hfkGuenrasmtalnihyc.herMidnerualfnascgor, (Ed. M. Fisher), pp.63-65, Bga-Schriften 94,4, MMV, F42o.wlFeirn,n,B.,WGEo,ttHsecmhsaltkr,eeC.tW.I,,MGcPC,onAnlelleln,, EB.EC..,NAonbdleer,sBo.n,,PaRrLke,r,BeJr.Cn.dta,ndW.P0or,teErp,stGe.iAn.,BFi.oHl.o,gFiocuMlakreks,erEsCf,a `UArciandareymyToPxriecsosl,og1y9,95B.oard on Environmental Studies and Toxicology, National Research Council, National ~~ + 43. NRC. Lippmann, M. Chiazzee, L, Coultis, D.B., Driscoll, KE. Kane, AB., Lockey, JE, McConnell, EE, aaOfnbeAdrsTdhooexrsistctooelsro,ogGyn.,d,SNRsahototimhoebntaeilrcgRV,eisLteRra.er,ocuUhsteFClilob,ueMnr.sc,:,aTnNhdaetIWinaofrnhlaeu)ieAtn,cceaDo.dBfe.FmRiyebpePorrerLsteso,nngpttph.h,e1BE-o6x0ap,red2r0to0Pn0a.EnnevliornoHnemaelnttahlEfSfteucdticss 4I4n.flAuTenScDeRo.fRFeipboerrtLeonfgtthh.e EAxTpSerDtR,PaDnicvl. oHenaHletahlAthssEofsfsecCtosnosfulAts,beAsttlaonstaa,ndGAS.ynMtahretcihc1V7i,tr20e0o3u.s Fibers: The Book Chapters, Published Symposta, Reviews: (Submitted!/in press) Abstracts, Letters to Editor: 61 . c1.hlVoarnodSitfet,uoErWo.m,eMtchCaonnen(e7l-2l2,).EEP,roPcaeteeld,iJng.s FainrdstHIanmtleirnna,tRi.oLna:lTChoengirnehsaslatoinonTotxoidcioellotygyo.f tAhceardeefmriigcerParnets,s, New York, p. 602, 1978. "2aPrsesKseis,smsmNmeeelnw,tYCooAfr,chkGrp,r.oann5it7c,3l,LeD1ad9,7t8Fo.oxiwclietry,. BPrAo.ceMecdCionngnselFilr,stEIEn.taenrndatWip:oondals,CoJng:reAsns ointeTogxriactoldogayp.prAocaacdhetmoicthe `3m.iMcec,Cognunienlela,piEgEs.. aTnd oMooxreA,ivoJ)Ac,:PhoTahremlaccoo,mlp.ar3a7t:1i4v6e,t1o9xi7c6i.ty of chlorinated dibenzo-p-dioxin isomerfsn 4i. bMecnCoznonrepll-,lEoEn.fnMoiocree,GAnd.uHanrreis,piMgWs.inadntdhHeassusemmoannk,e1yD.s}.TEhoento,xicHietayolfthcPhelroerpi,na2t0e2d45, 1977. (.TTChDiDg)peonn,hJoEs,t MrecsCiosntnaenlcle,tEoEi.nfMecotoiroeu,sJaAg.enatsn.dEFnavitihr,oRn,EH:eaElftfhePcetsrsopf.22.307:,284t5e,t1r9a7d7B:lor+odib+enzo-p-dioxin . 6h:alMocgCeonnanteeldl,diEtEi.inasn,dfMucrKanisn,nebiyp.hJeDns:lsExaqnudisniatpehtthoxailceinteysi.n tTheoguixneAapippli.cgPthooarstmlrauccot.lu.ra4ll5y2s9i8m,il1a9r78. c7.omMmoeorrceia,lJpA,olLuysbtreorm,iMnoa.tedGubpitpah,enBylN!.mainxtduMrceC.onTnelol,xEEA.pi:plTc.oPxhioacorlmloagcio.cla.la4n5d:1i7m6m,u1n9o7l8o.gical effects ofa I8Mn.escMttictiCunotgen,onfeMlatlhyeE2IE3n.,tea1r9na7dg9eM,noBcoeyrtehC,oelsLldAaab:,orMTaDot.xiviecoGpraotuhpoloongyEnchvairraocntmeerinsttailcsCaorfctihneogheanleosgiesn.atNeadtiaornoamlatCiacnsc.er45th 9cc.aormBcpoiaonroragmteaninev,seisGe..fAf.Fe,cetdMsecrCoafotnainnoenalonlfiEmALam,lesrCiaocgckearnealtSlot,ciiBm.ceYt.io,ofsDerfxeopwro,EsxRup.rTe.er,iaSmntedonnteeax,lpCo.BJsi.ou,lrHoegayds,urAmanatanih,oenJiXom.n, avinndylMocholroer,idJ.eA:: CA, April 15.18, The S 1980. I110m9.p80aM.cctKionfnCehyl,o1r.i0.naaindd DMicoCxoinnnselaln,d EREel:atSetdruCcotmurpaolusnpedcsifoicnittyheanEdnvti\hreodnimoexnitn,rReocmepet,orI.talWy,orOcktsohboepro2n2-24, (LTL.CDMDcC)otnonxeilclit,yElEip.idanadssSihmoialfa,tiConR..1.(1M9o8r1p)hoSltougdiye.sPohfamtahecomleocghiastn,is2m31o1f762.,3,7.8-tetrachlorodibenzo-p-dioxin T12o.viMccoCloongyneFlolruEmE,:WaHsihsitnogptaotnh,olDoCg,y w1o98r3k.load in carcinogenesis bioassays. Howmuch is necessary? The T13h.eMTcoCxoincnoellolg,y EFEo:rumP,rolWiafsehraitnigvteolne,siDoCn,s o1f98t3h.e exocrine pancreas in male F344 rats - the effect of com ofl. A14n. eSaolslyevcehlodi,ceHAwh.eHnausseinmgatnh,e Pathologists, Sen Antonio, T, 1FK.isacnhderM3c.C4o4nrnaerlla,s 1983. aEEo.stLianfiemsapla.n oAnmetrwioc-yaenaCrosltluedgieeosffoVretcearricnianroygen testing: g1u5.inMecaCopningesollf,diEoEx,inHairnrissoi,l.MWS.orieHtayrvoafnT,oDx.iJc.,olAolgbyr,o,AtPlWan.taa,ndGAH,as1s9,84J,R: Studies on the bioavailabiliitny 62 * I1n6t.eSronlalteivoenladl,SH.yAm.poasmdiuMmcCoofnntehlel,SocEiEe:tyoTfinTeo-xaigceolaosgsicocPaitahtoilooigninsstesx,pAerrliimnegnttoanl, oVnAc,og1e0n8e4sis. Third : M17a.nMacgCionngneCloln,duEcEt:anQudaDliattyaaQnudaltihteyoNfatTiooxniacloTlooxgiycSotluodgiyesP,roRgalreaimg.h NNCT,P-19I8n5d.ustry Joint Conference on S1t8u.dMiceCs.onnInetlelr,naEtEi:onaGluLiidfeeliSnceisenfcoersCIonmstbiitnuitengHiNsetooppaltahsomlsogfyorSEevmailnuaart,iHoannoofveRro,deGnetrmCaanrcyi,no1g0e8n5e.sis U19S.-ADdukticnhsIJnrt.eBr.n,atMicoCnoanlneSlylm,poEsE:iumI:nhaAleartoisoonlsC,arWciilnloigaemnsebsuirsg,SVtiurdgyinoifa,Wo1l9l8a5s.tonite- in Rats. Second C20a.rcMicnCoognenneilcilt,yESEr:adiOepst,iCohnaspefolrHAilglg,rNeogratthioCnarooflIinnc,id1e9n8c6e.Data. Interdisciplinary Discussion Group on `2E1n.giMnceCeornsn,ePlhlo,enEtEs:, AFriibzeornTao,xi1c9i8t8y.: Beyond the Stanton Hypothesis. American Soc-ietyof MiningFR> M2e2e.tM.c,CSooncn.eTlolx,icEoEl., HAetljatnmtaan,cGikA,,M1.98P6e.ters, A.C. Persing, R. Chroni.c Toxicity of Pentachlorophenol. Ann. T23o.xiAcdokli,nAst,laB.n,taM,cCGoAn.ne1l9l8,9E.E, Hall, L. Carcinogenicity StudiesiofWollastoniteinRats. Ann. Meet, Soc. o24f.tMhceCNoantnieolnla,l EToEx,icHoalsogcymaPrno,grJA.amanDdatBaoBoarsmea.nA,niG..AM:ePerto.liSfoecr.atTiovxeiLceosli,oMnsagoif,thFeLT,h1y9r9o0i.d Gland: A Review| E25x.poMscuCroen.neilnlS,imEiEla.riCtoimcpsaarnadtiDvieffReersepncoensseBseriwneCeanrcCihniolgderneincaBnidoaAsdsualytss:asImaplFiucnacttiioonns offorARgiskatAFsisresstsment, ILSI/RSI, Hunt Valley, MD, November, 1940. RC2a6ht.rsoH.neAisnctneIr.nbhMeaerlgea,tti.ToSnWo.Tco.xMTiaocsxitit,cyoRal.n,dMDcaGlCnlocanosng,TeeXnli.lciL1tE9,y91SVtoaugldseyolo,TTfhOo.eRx,eifChrceaovclatlooirgeyri,CseJtr.aBmeirmcsFtiebienr,sD(MRC.P)anidn FAinsdcehresro3n4,4R. 11:85 (254), 1050. . E2f7f.eMcctsCoonfnCehlrly,soEtEi,leHoasntderCbroecrigd,oTli:tWe,AHsabdelsetyo,sJ.inG,RaBtesrnAsftteienr,InDhMa.latainodn Mfaosrt1,0RMWo.ntAhsC.oAmnpna,rMieseotn.oSfotch.e Toxicol, Seattle, WA. 1992, aso The Toxicologist 12:90 (274), 1952. . S28t.udGylaosfs,ReLfRr,a,cMtaosrty,CReWr.a,miHcesFtiebrebre(rRgC,F)T.iWn,,RaAtnsde~rsFionna,l RR.esaunltds.McACnonp.neMlelt,.EES.ocI.nThoaxliactoilo,n SOenactotglee,niWcAl,ty 1992, alsoTThoexicologist 12:377 (1477), 1992. S`2e9O.antctMolaegs,etnW,iARc,iWy1.S9t9Mu2cd,CayolnosnfoeKTlalhoo,elxiEinEc,RoelGflroaagscsit,osrLtyR1C,e2Hr:ea3smt7iecr(1bF4ei7rb8ge),r,T(1RH9C9,F2)-.AndFeirnaslonR,esRu.ltasn.dABnenr.nsMteeeitn., SDoMc.. ToIxnihacloalt,ion E30f.feMcctsCoonfnCehlrly,soEtEi,leCahenvdalCireorc,idJo.lHietsetAesrbbeersst,osTWi.n, RHaatdslaefyt.erJ.IGn.h,alaantdioMna.sitn,TRoWxi.colAoCgiocmpaanrdiCsaorncoifnotgheenic 63 GEfefremcatsnyo,f 3SoMliadrPcahrt1i9cl9e3s in the Respiratory Tract. 4th International Inhalation Symposium, Hanover, "31A.ndeHresstoenr,beR.rgC,hTrWo.n.icMiIlnlhearl,atW.iCo.n, ToMxciCcointyneolfl,FiEbEr,ouHsaGdllaesys, i1nG,RaBtesr.nsitneTionv,icDolLo,giTchaenvdenCaazr,ciP.noagnednic Effects MofarScolhid19P9a3rt.icles in the Respiratory Tract. 4th International Inhlation Symposium, Hatinover, Germany, 3 i3n2.trMaatrsatc,heRaWl ,anGdlaBsiso,peLrRs.i,sMtcenCcoennSetuldlieLsE,ofHeRsetferracbteorrgy, CT:eWr.a,maicfdFiAbnedres.rsionnT,oxRi.cCohlorgoinciacnIdnhCaalractiinoong,tnic EGfefremcatsnyo,f 3SoMliadrPcahrt1i9c9l3e.s in the Respiratory Tract. 4th Internatio" nal Inhalation Symposium, Hannover, t3o3x.iMciatsyt,StRuWdy.oMfcKCaoonlnienllRe,fEraEc.toGrlyusCse,rLaRn.icanFdibHeers(tReCrFb)erign,MTaWl.e FiAscMhuelrti3p4l4e DRaotsse.TTChhireioncioclInohgailasttion13:43 (63), 1993. } . + C34h.ryMscoCtoinlneaelnld,CErEoc.idHoelsitteerbAesrbge,sTtWo.s,inHaRdaltesy,af.tGe,r,ianhnadlaMtaisotn,-R2W4.MoAntCohmRpeasurlitsso.nTThoofextcheoElfofegcitssotf13:43 7), 1993. `3A5r.ocMlaoyresM,ixBt.uAr.eNseAadlm,iJnHi.s,tePerteedrsi,nAt.hCe.DHieatmitlotSonp,raSg.8u.e,-MDcaCwoknneeylRla,tEsEf.oranSidxMMooonrteh,sJ.ATT.hoCexhriocnoilcoTgoxiisctity of 14371 (1438), 1994. R36.eHasdlepy,oT1.hGe.n,ToMsxciCcoeonlnsoeglil.s,tE1E.4:a4n2d0 (J1o6h6n5s)o,n,19N9.4F,. Fiber Inhalation Studies,Lung Burdens and Biological C3h7.rysMoctCiolnenealnld,CEroEc,idHoelsitteerbAesrbge,stTo.sW.inHtahdeleLyu,nJgGs.oafnRdatMsusafsteelrmIannh,alRa.tiAonC.TohmepTaorxiicsoolofngitshte 1Ef4f:e4c2ts(o1f666), 1994 ": A3r8.oclMoaryemsi,xtBuAr,esNaeadlm.inBiHs.t,erPeetderisn,tAh.eCd,icHtamtiolStporna,gSu.e8-,DaMwclCoenynrealtls,fEoEr.twaenldveMomoornet,hsA..TThoCehxriocnoilcotgoxiiecist,y of 1995. 39. McConnell, EE. Letter 10 Editor: Cambelova and Juck. Occup. Environ. Med., 52:1995. O40b.erHdeosrtsetrebre,rgG,. TEWst,imMactCionngntehlel,MEaEx,imMiulmlleTro,lWe.rCa.t,eCdhDevoasleie(rM,TJD,)EfvorearFtiJ,.beTrhCehvreonnatizc,IPn,haFllaetiiosns.neSrt,uHd,y iannd RodTehenToxticosloi.t, 30:291, 1996. 41. McConnell, EE. Commentary on Fibrous Glass and Lung Cancer",Am.IInd,Med. 1996. G4.2."Hbeastleartbieorng,ToTxAiYc,itMycoCfoSnynnetlh,etEiEc,ViMtirleloeurs, FW.iCb.e,rsChCeovmalpiaerr,edJ.fEoveArmitots,iJt,eTAhsebveesntaozs,inP.,thaendHaOmbsetredro"r,ster, (scheduled for Sept. 1996). 43. McConnell, EE. "Conumentary on "Fibrous Glass and Lung Cancer",Am. 1.Ind.Med, 30:111-112, 1996. 64 4c4h.ryMscoCtiolnenealnld,aEmEo,siMriellaesrb,eWs.t,osHeisnthearmbsetge,rsT:aW.fteTrhienvhealnaatzi,onP:.IanntedrAixmtreens,ulCt.s.ATTchooexmipacroilsoogniosftt,h3e6e:f6fe(c3t3s),of : 1997. " 4a5n.dHOebsetredrobresrtge,rT,.GW..,SMucbCcohnrnoenlilc,iEnEha,laMtliloenrs,tWu.d,y Cohfevfailbireoru,s1g,laEsvesriitntt,hJeTShyervieannatgzo,ldPe,nFhlaemissstneerr., ETLh,eHart, Ge Toxicologist, 36:6 (35), 1997. r46e.spMoanyseess,iBn.AS.p,rNaegaulc,-BDaHv.iePyetrerast,s Toxicologist 36:18 (80-4), 1997. Af.edC.ArBorcohwlno,rsJ. 1F.0,1H6a,m1il0t4o2n,12$5...4,'aMncdCo1n2n6e0llf,orEoEt.woanydeaMros.orTeh,eJA. Tumor . 4a7n.coMgceCnoincneelflf,ecEtsE,ofMvialrliero,usW.t,ypHeesstoafrbaersgb,esTtWoi.nsTrhoedveenntasz,afPt.eralnidfeAtxitmeeni, Cn. AhcoamplTahraeisTtoonxiiocfootlhngeis.t, 42177 (876), 1998. ji . a48n.dHOebsetredrobresrtge,rT;WG..,EAsxttiemna,tiCn.g, Htahdelmeya,xJi,mMucmCotnonleelrla,teEdEd.osMeilolferf,ibWe,r,gClhaesvsalfioerr,a ,cirEovenriictti,nJh,alTahteivgennsatzu,dyB. * using Syran golden hamsters.TThoexicolowist, 421177 (877), 1998. : 49. Axten, C. McConnell, LE.. Hesterberg. TV. Hadleb. JG. Miller W... Thevenaz, P. and Chevalier, J. Chronic inhalation + t(o8x8i0c)i,tyo1f99t8w.o typesoffobrous glass nd amie asbestos asbestos in Syrian golden hamsters.TThoexicologist, 421177 50. Kamstrup, 0, Davis, JMG. Ellenhauge, A. and Guldberg, M. Pathogenicityofman-made vitreous fibers after long-term inhalation.TThoexicologist, 48(1-5), 1999. f5i1b.eMrscCaofntnereliln,haElEa.tiUonseexopfotshuerer.odPernotcedeidaipnhgrsaogfmtahned7*thIonrtaecrincatwiaolnlafloSdyemtpeorsmiinuemtornanPsaprlteiucrlaelTmoixgIrcoaltoiRoYn.of Maastricht, The Netherlands. 13-15 October 1995. g52o.ldMecnCohnanmeslilc,rsE.E.PrAocceoemdpianrgissoofntohfe p7l*euIrnatlermneastoiotnhaelliSoymmapsosiniduumceodnbPyaratiscbleesTtooxsicaonldogSyV.-4M0aavsitrruischitn,STyrhiean Netherlands. 13-15 October 1999. of53.poAtxetnetni,alCpWa,thHoapdhlyesyi,oJl.ogHyes-tReersbuelrtgs, oT.,afMcchCroonnnieclilnhEaEl.atainodn Msitluldeyr..PFriobceerebdiionpgesrsoifsttheenc7e*aIsnaterniantdiiocnaatlor Symposium on Particle Todcology. Maastricht, The Netherlands. 13-15 October 1999. D54o.tT,heAv.eInnafzl,uePnhc.eJoofnmese,thAoDd,olMoiglyleorn, Wr.e,poArxtteedn,huCn.Wg.b,uHredsetneragnerdy,fiTbeWr.coHnacdelnetyr,atJi,oMncsCfoonrnienllh,alEatEi.onand IsnttuedrineastwiointahlmSaynm-pmoasdieumfiboenrsP:arPtairctle1T-oxAiccroolsoogly.geMnacarsattriiocnhta,nTdheexNpeotshuerrekimnedtsh.od1s3-.1P5rOoccteoebdeirng1s99o9f.the 7 5256.MIcnCtoenmnaetlilo,naElECoAngSrceisesncoen-bOacsceudpAaptipornoaalchHetaoltthh,eSCilnagsaspiofricea,ti2o7n-o1fSSeypnttehmebteicrV2i0t0r0e,ous Fibers. #7P 44, W56o.rkDsehvoepl.opHiEngSIStIrnatteergniaetsiofnoarlAgLrifiecuSlctiuernacleCshIenmstiictaulte,SaWfaesthyiEnvgatlouant,ioDnC;,ASeRpetpeomrbtefrr2o0m0a1n April 22-23, 2001 65 11.56"6L.ymphosarcoma in Domestic Animals," Armed Forces Institute of Pathology, Washington, DC, March 2. "The Clinician and Pathologist." South Africa VMA (WITS) Congress, May 1670. : 13.97"0E.xperiences with Animals at the Kruger National Park," Verrinary Faculty, Onderstepoort, September P4.ie"tTehrsebRuorgl,e oOfctaoVbeetrer1i9n7a0r.ian in the US. Air Force." Eastern Transvaal Veterinary Medical Association, S5.epAtnetmhbrearx1i9n7a1n. African Buffalo from the Kruger National Patk." CongressoftheSouthAfrican VMA, 196.7"2R.espiratory Acariasi2s Chacma Baboons," Science Week-1972, WITS University JohanneBsbsurg, June *" o7.f "tPhaethVoeltoegriicnaalbyObRseesrevaartcihonIsnsitintu1t0e0, BOandbeorosntsepforoormt,thJeulKyru1g97e2r.National Park, VeterinaryFaculty and Staff 8I.ns"tLietsuiteoonsfPinatFhroeleo-gRya,nSgeipngteBmabbeoorns1,7"2P.athology of the DiseasesofLaboratory Animaa ls, Armed Forces T9.oxLiecsoiloognys,FWoruinghdt-iPnaAtntiemrasolnsAEFxBp,osSeedptteomCboearl1T9a7r3,Acrosols, 4th Ann"ual Conference on Environmental `1A0.nto"nAinot,hTrXa,xDinecaenmAbferric1a9n7B3u.ffalo." American College of Veterinary Pathologists Anmual Meeting, San o11f. T"oxTihceoCloomgypaArnantuiavleMTeoextiicnigt,y oAftlCahnltoar,iGnAa,teMdaDricbhen1z9o7-6p.-dioxin Isomers in Mice an-dGuinea Pigs," Society 12. "The Toxicopathology of TCDD," Workshop on TCDD, Milan, Italy, October 1976. U1n3i.v"eTrosxiitcyoloofgCiaclailfoRrensiea,arDcahviPsr,oOgcrtaombserat1t9h7e7.National Institute of Environmental Health Sciences," O14c.toTbrearin1i0n77g.of Comparative Pathologists for a Carcer in Toxicology," University of California, Davis, a15n.d "NEaxpqhutihsiatleenTeosx.ic"it1y7tihn AtnhneuGaulinMeeactPiingg,10SoStcriuecttyuorfalTloyxSiicmoilloagry.HaSlaongFernaantceidscDoi,oxCiAn,s,MaFrurcahns1,07B8ip,henyls S1c6i.eTnocexsi,coNpeawthYoolrokg,yNYC,haJruanceter1i9s7t8i,cs of Halogenated Aromatics," Science Week, New York Academy of C17o.lu"mPabtuhso,loOgHy,aMnadyTo1x97i4c1o.logy of Chlorodibenzodioxing in Laboratory Animals," Ohio State University, U1n8i.ve"rCshirtoyn,icCoTlouximcbiutsy,oOfHT,ecMhanyica1l97a9n.d Analytical Grade Pentachlorophenol in Cattle," Ohio State 66 + W1e9.sh"iCnogmipoanr,atDiCv,eMTaoxyic1i9t7y9.of Related Halogenated Hydrocarbons" Armed Forces Institute of Pathology, . 2G0r.o"uTphoenToExnivciorloongmyenotfaDliCbaernczionfougreannessiasn,dNaDtiiboennazlodCiaonxcienrs,I"as4t5ittuhteM,eBeettihnegsdoaf,tMheD,InMtaeryag1e9n7c9y. Collaborative N21o.rt"hCoCmapraorliantaivSetaTtoexiUcniitvyerosfitTye,cRhanlieciaglh,anNdC,AJnaulnyeti1c9a7l9P.entachlorophenol inCattle,"NIEHS Science Fair, D22i.sc"aTsheeALsessoicoinastiIonnduMceeetdinbgy,RUenliavteerdsiHtayloofgeOnkaltaehdoAmrao,maNtoircmsani,n VOaKr,ioAuusguSspetci1e9s7o9f. A-nimals," 1979 Wildlife M2e3.et"iEnsgs,eNntIiEaHlSs,oRfeRsoeuatricnhe TPraitghnogtloexiPcaoclko,gNyC,EvNalouvaetimobne,r" C1o9n79s.ensus Development of Immunotoxicology $ A2g4r,i"cTuoltxuircaolpaRtehsoelaorgicchaalnSdynDedvreolmoepImnednutceCdenbtyerR,eWloaotsetdeHra,lOoFg,enAautgeudsPtol1y9c8yc0l.ic Hydr1ocarbons," Ohiv o yv D2i5s.tr"iTchteINVaAtAiLonAsSTSoexmiicnoalro,gyRaPlreiogghr,amN,C",CMoanrscehrv1a9t8i1v.e Trends in Lubo. ratory Animal Science, Eighth Annuagl P2h6t.h"aNlTatPeTEesstteirngCoRnefseurletnscwei,tWhaEsmhipnhgatsoins,oDnC,BiJouansesa1y9s61o.f DEHP, DEHA and Buty] Benzyl Phthalate," 2o7f.th"EefSfoecctisetoyfoSfuTbocxhircoonliocgyC,hlRoersdeaerccohneTrEixapnogsluerPearokn, tNhCe,FJeartniulaitryyo1f9F8e2m.ale Rats," North Carolina Chapter `2W8a.s"hEivnagltuoant,ioDnC,ofDPeactehmobleogry1R9e8q2u.irements," Third Annual Meeting of the American College of Toxicology, U29S.EPNAI,ECHiSncAisnbnaetsit,oOsHF,eeNdoivnegmSbteurdy19-5H2a.msters and Rats," Summary Workshop on Ingested Asbestos, F3o0.r"uHmisAtnonpuaatlhoWliongtyeWroMrekeltoinagd,iAnrClianrgciionno.geVnAe,siFsebBriuoaarsysa1y9s83-.How much is necessary?" The Toxicology . 3T1o.xi"cPorlooligfyerFaotirvuemLe1s9i8o3nsAnofnutahel EWxionctreirneMePeatnicnrge,aAsrliinnMgatolne,FV3A4,4FReobtrsua- rTyhe19E8f3f.ect of Com Oil" The 32. "Toxic Of Syndrome," WHO Meeting, Madrid, Spain, March 1983. T3o3.xd"cAonloIgimcprPoatvheodloPgriosttosc,olCrfyosrtaBlioCaistys,ayVaS,tuMdaieys,1"9283n.d Intemational Symposium of the Society of 3Po4t.e"ntCiharlonHiecalTtohxiEcfifteyctosfoPfCPBolyacnhdloRreilnaatteeddCBoimphpeonuylnsdsanidn VRealraitoeudsPAenrismisatlenStpeHcaileso.g"enCaCtEeRdPHCyodnrfoecraernbcoenso,n NIEHS, Research Triangle Park, NC, September 1983. O3c5.cu"pTaotxiicointaylofHPaCzBasrd,sPColayucsheldorbiynaPtoeldycDhilboerniznoafteudraBnisphaenndylDsib(ePnCzBoSd)iaonxdinCsh,i"oIrnotberennazteinoenasliWnoCrapkaschiotporosnand Transformers, Espoo, Finland, September 1953. 67 , L3a6n.s"iDnigo,xiMIn,s DinectehembEenvriz1o9n83m.ent," Human Health and Toxicity Workshop, Michigan State University, East D3i7.be"nTzooxfiucraannsd,C"aFrecdienroagteinoincoRfeAsmpeornsiecsaninSoEcxipcetriicmsefnotraElxApneirimmaelnstAaldmBiinoilsogtye,reStd. DLioubiesn,zMo-Op,-dAiporxilins19d8n4d. 3M8e.et"iLnegs,ioDnusirhnaAmn,iNmCa,lsApErxilpo1s9e8d4.to EDR," North Carolina Chapter of the SocietyofToxicology Spring, 3G9A.,"MSatrudcihes19o8n4.the Bioavailability in Guinca Pigs of Dioxin in So' il" Society of Toxicology Meeting, Atlanta, 40."NTP Program Update," European Toxicology Forum, Geneva Switzerland, September 1984. 4E1n.vi"rTohnemReentsaplonTsoexiocfolNoTgyP,tDoatyhteonR,ecOohimom,eOncdtaotbieorns19o8f4.the Ad Hoc Pancl," 15th Conference woon. * 4M2e.etNiantgi,oWnaaslhTionxgitcoonl,ogDy.CP.roFegbrraumarStya1t9us85a.nd New Initiatives," The Toxicology Forum 1985 Annual Winter 4S3t.atiRsetliceavlaPnetrsNpoenc-tSirvaet,isAtmicearliBciaonasStsaatyisItsiscuaelsA,s"sSocyimatpioons, iWaousnmhilnogntgo-nt,erDm.AC.niMmaarlcChar1c9i8no.genicity Studies: A 4B4h.op"aTlheTrSahgoerdtya,nTdheLoWnogrkTeerrsmPHoelailcytPhroajnedctE,nvNierwoanrmke,nNtaelwIJmeprascetys,,M"aCrocnhfe1r9e8n5c.eontheImplications of the 4U5n.iv"eArsditHyocofRCeipnocritnnoantiC,hOehmiioc,aMlaCyar1c9i8n5o.genesis Testing and Evaluation."En.vironmentalHealth Seminar, . 4H6i.st"oCphaatlhloelnoggeys SaenmdiOnpaproortnunthietiReesprfoorduPcattihvoelSoygsitseitmnsotfhLeaNbaotriaotnoarlyToAxniicmoallosg,yHParnoogvrear,m,G"eIrLmSIany, September 1085. ' `4AA7nn.ailm"yiTsdhises,JLHueassntiioofvniescra,itniGotenhrfemoRaranCry.o,"mLbSSeiTpntiHenimgsbtBeoerpnai1tg9hn8o5la.ongdyMSaelmiignnaarntonTutmhoe rRse=p(roordNuocttiCvoemSbyisntienmg oTfhLeamb)orinatSotraytistical 4S8y:st"eMmetohfylLaIbsoorcaytaonrayteA-niPmraellism,iHnaarnyovSetru,dGyeRremsualntys,,"SLeSpTteHmibsetrop1a9t8h3o.logy Seminaron the Reproduyctive 4C9L.."DOavveirsviSeixwthofAhnneuaNlatiSoynmaploTsoixuimc,olCohgeyshPirroeg,rEanmglianntdh,eSUenpitteemdbSetrat1e9s85a.nd Findinigns Selected. Studios," C5109a.8n5".eCrarIcnisntoitguetnee:si1s97S-t1ud9i8c5s."ReCsoullltsegfiruonmRtahmeazUz.Si,ndN,atLiiovnianlg TionxaicCohleomgiycaPlroWgorralmd,aBnodlotghneaU,SSI.taNlya,tiOocntaolber C51h.emMiectahlyWloernled,ChBloolroigdnea,,MIetralhyy,lOcchtloobreorfo1r9m85a.nd Trichlorocthylene. Collegium Ramazzini, Living in a R52a.ma"zLzivienri,FoLciiviFnogrmiantioCnheDmuircianlgWAofrlladt,osBionloCganrac,inIotagley,neOscitsoibnerRa1t:985A.Quantitative Study," Collegium 68 53. "The Toxicity of Methy] Isocyanate in Rats and Mice," New Delhi and Madras, India, February 1086,, : "54Ev.alRuaetsipoon,n"sSeoctioetthyeoIfnTtoexgircaotiloongyofAnRneucaolmmMeeentdiantgi,oNneswofOrtlheeanAsd, HLao.e, 1P9a8n6c.l on Carcnogeacsis Testiag and &5T5.ox"iNTcPSSutbrsattaengcyefsoSreCmoimnbairnPirnoggrNaemo,plEaPsA,msWafsohriEnvgatlouna,tiDo.nC.o,fACporricli1n9og8e6n.csis Studies," Office of Pesticides M5e6.et"iEnngv,iSrto.nLmoeunitsa,lMTisosxoiurcio,lAopigrnyilt1h9e6M.id Eightics: Interfacing with the Tosicologist." FASEB 70thAgmual `5A7p.ri"lNT1P9'8s6.Response to the Ad Hoc Panel Recommendations," FEMA Annual Meeting, Palm Beach, Florida, :|, | N58o.rt"hStCuadrioelsionna StthaeteToUxniicvietrysiotfyMMeitchryolbiIosolcoygaynSateem,intaher CSehreimeis,caRlalReeisgpho,nNsoirbtlhe CfaorrotlhinegB,hAoppeall D1i9s8a6st,er," oF . 5S9t.ud"iOepst(AiLoSn!sNfFo)r,ACghgirpeeglatHiiloln, oNforItnhciCdaernocleinDea,raJ.u"neIn1t9er8d6i.sciplinary Discussion Group on Carcinognicy ++ 6A0s.pe"nN,TPCoElvoarlaudaot,ioJnuloyf1E9x8p6e.rimental Studies," The Toxicology Forum 1986 Annual Summer Meeting, `GTLh.e"TNoTxPicRoelsopgoynFsoertuomt1he9R8epAonrtnuof]tShuemAmdeHroMceePtainnegl,oAnspCehne,miCcoallorCaadroc,inJuolgyen1e9s8i6s.Testing and Evaluation," O6c2.toIbnehra,la1t9i86o.n Study of Wollas-tonitien Rats," SAE's 4th Annual Colloquium on Brakes, Atlantic: City, NJ. * 6M3a.nu"fCaocntsuirdeerrsa'tiAosnssociinaDteitonerDmriunginSgaftehteyESsutbismcactteidonMamexeitminugm, TNoaslhevrialtleed,DToNs,e,N"ovPehamrbmearc,eu1t9i8c6a.l GP4r.og"rCaumr,r"en2t6tShtaArnunsuoafltMheeeItsisnuge ooff MthaexSiomciuemtyTooflcTroaxtiecdolDoogsye, W(aMsThDi)ngwittohni,nDt.hCe;UFSe.brNuaatriyo,na1l9T8o7sxicology o6f5.Go"vFeedrenramlenPetrTcoexpitcioolnosgiosft0s,aBredthCeesrdtai,fiNcaDt,ioMn,a"y,Sp1r0i5n7g.Meeting and Reception for Members of Association 6C6h.loGraovbaegnezeSnteudPireosduinceMrisceAsusnocdiaRtatiso,n"),PWuarasdhiicnhgltoorno,bDe.nCz.e,nuelSyym19p8o7s.iun (Sponsored by CIT andl J6u7l.y"1N9T8P7.Database." Meeting of the Ad Hoc Working Group on Carcihogenicity Testing, Washington, D.C., E618n9.8v7iR.raopnpmoenrttaelurHeaarlMthouCsoemiLitvtereeanadndRaHtaKliodgneenyatTeudmOorrgsanWiocrskSsuhbocpo,mEmiPtAteScei,enWcaeshAidnvgitsoonr,y DB.CoardA,ugust 69. Toxicology Learned the Hard Way," Principles of Toxicology, Boston Univ. August, 1085. 69 7L0o.ss".Mouse Liver Tumors: The Problem," Mouse Liver Carcinogenesis Conference, Aust, TX, November, "71S.tud"iBeis,o"loCgoyuIrssseucosninBiotshteatSitsattiicsst,icIalntEevmaaltuiaotniaoln AofgeRnocdyenftorCRaerscicnaorgcehniocnitCyancer, Lyon, France, Deceri.ber, 1988. o : 72. "Pitfalls Toxicologic in Carcinogenesis Testing," North Pathology", December, 1985. Carolina State University, Graduate Course VMS 643 "|Rodent R73e.se"aMracxhiTmriuamngTloeleCrhaatpetderD,osSeoc:iTethye fDoerbaRties,k"ABnarloyoskiisn,gRseIsncsatirtcuhteT,riWaansghlienPgatrokn,, NDC.,C.MaMya,y,191899.89'and EC7ni4.vnic"irTnohnneamseS,netaOarHlc,hHMefaoayrl,tAhd,1e9Aq89un.aatelBNieocatssianyg Doafttah:eCSroucdieetByifoolrogEynvVierr.osnumseSnttaatilsGtiecosc,"hTermaicsetvrSyubasitdaHnecaelst,ihn, , W75o.rk"Asnhiompal1,BCihoiascsaagyos.:IUL,siJunngeP,ro1t9o8c9o;lAstalanndtaI,ntGeAr,prDeetcinegmRbeesrul1t9s,8"9.RegionalRiskAssessment W"orkshops, 76. "Target Organ Toxicity in Carcinogenesis," Anmual Summer Toxicology Forum, Aspen, CO, July, 1086. A77s.se"sTosxmiecnittyaTnedstMianngangedmeEnvatl,uaCthiuolnab-PhroacrtnicRaelseCaorncshidIenrsattiitoutnes,."BaInngtekronka,tiTohnaallaTnrda,inDiencgeWmobrekrs1h9o8p9,on Risk t78h.e S"oUcpideattyeoofnTotxhiecoSleoagryc,h MfioarmAyd,eqFLu,aFteebrBuiaorays,sa1y99D0a.ta: Crude BiologyVersusStatistics," Annual Mecting of 79. "Biological Effects of Dictary Restriction: An International Conference', Washington, D.C., March 1990. " 80. "Principles of Routc-io-Route Extrapolation," (Rapporteur), Hilton Head, SC, March 1990. + L8a1bo"rMaotloercyu,lNarY,MeMcarhcahni1s9m9s0.of Fiber Cytotoxicity and Carcinogenesis," Banbury Ceater, Cold Spring Harbor g82e.no"tNoTxPicCCaarrcciinnooggeennse-siIsn,teWroprrledtatHieoanlatlhPOrrogbalneimzsa,t"ioInn,teBrrnuastsieolnsa,lBWealsgkisumh,opT:unEear1l9y9I0n.dicators of Non 8139.90P.rinciples of Carcinogenesis," School of Pharmacy, Campbell University, Buics Creek, NC, October, S84i.nu"lCaroimtpeasraatnidveDiRfefserpeonncseessBienrCvaerecninCohgielnderseinsaBnidoaAsdsualytss:aismaplFiucnacttiioonns foofrARgieskatAFsisresstsEmxepnots,urILeS,I"/RSI, Hunt Valley, MD, November, 1990). I8m5.pl"iFcrahtyiloennsefTohrioRuirseka:AssAeCsassmeenStt,ud1yL,S"I/SRiSmIi,laHruintitesVaalnledy,DiMfDfe,rNenocveesmBbeetrwe1e99n0C.hildrenandAdults: L86e.ct"uPrreosbalsempsaratndofC"oTnosxiidceolroagtiiconPsatihnotlhoegyD"esciogurnsae,ndVMInSteGr4p3r,etCaotliloengoefoRfoVdeetnetriCnaarrcyiMneodgiecniensei,sNSCtSudUi,es", December, 1990. 70 U8n7i.v"eTrosxitiyc,olMoagricchS,tu1d9i9c1s.", Man-made Mineral Fibers: Status of Health Risk Assessment', Johns Hopkins 5y T88r.ia"nFgilbeerPaTrokx,icMiatyy -1B9a9c1.kground and Historical Perspective", Society of Toxicologic Pathologists, Research.3 P89h.ar"mAanciomlaolgByiowaosrskasyhIospsu"eAs,RUesveieowfoGfRRAi",skInAtsesrensatsimoennatl SaoncdicOtyMoBf RReegpuolrattoorny iTtosxAicpoplloigcyaatndi.ion Regulatory + Agencies", Crystal City, VA, June 1991. V9e0.te"rTihnearDyesSicgine,ncCeoDnedputc.,tPaenndtisIynltvearnpiraetSattaitoen UonfivFeirbseirtTyo,xPiAc,itSyeSpttuedimcbse"r, A1.99L1..Bogtree Lecture Series, F9i1b.er"sF"i,beIrnTtorxaimcuroallogFyibienrERxepseerairmecnhtWaolrAknsihmoapl,s:NaRteisounlatls IonfstSitruudtieesfworitOchcNuaptautriaolnaalndSaMfaetny-aMnaddeHeMailntehr,al Morgantown, WVA, September 1991. | J F9i2b.er"sC"o,nWdourcktsahnodp:InAtpeprrproeatcahteiosntoofFIanlhuaaltaitnigo,n tShteudTiocxsicoiftythaendToCxaircciitnyoagnedniCcairtcyionfogMeannic-iMtaydoefFMiabger-sM.ade. = *. Durum, NC, November 1991. ++ F9e3.br"uMaarny-1M9a9d2e. Fibers: Review of Toxicology Data', '92 Annual ToXcology Forum, Washington, D.C., 94. Invited testimony before the German MAK Commission on MMVF'. Munich, Germany, May 1992. O95.f"Mffaonr-iEMuacrdoepeFei,brCeosp:eVnahlaidgietny,of19M-e2t0hMoadys,f1or99A2s.sessment of Corcin.ogenicity of Fibres", WHO Regional . 2963.S"eEpvtal1u9a9t2i.on of Reduced Protocols for Carcinogenicity Testing of Chemicals", EPA, Washington, DC, 22W97o.rk"sChoomppa,rSatt.iPveetePrastbhuorlgo,gFyL,of20Ch.rJyasno1t9i9l3e.and Crocidolite Ashestos", TIMA/NAIMA Fiber Science P9e8t.e"rRsebluartgi,onFsL,hi2p0BJeatnwe1e9n3P.ulmonary Fibrosis and Cancer, TIMA/NAIMA Fiber Science Workshop, St. . T9o9x.i"cTohleogTiocxiPcaotlhoogliocgyPaitnhoSlaofgeitsytAisnse2s0s0m0enAt..D:NaNteieodnsalfAorcaInddeumstyryo,f SGcoiveenrcen,mWeansthainndgtAacna,dDeCm,ia1"0, FReoble1o9f93. T1o00x.ic*oAloCgiocmpaanrdiCsaorncionfotgheeniEcffEefcftescotsf oCfhrSyosloitdilPaeratincdleCsrioncitdhoeliRteespAisfbaetsotroysiTrnaRcat.ts4tahftIenrtIenrhnaaltaitoinoanl", Inhalation Symposium, Hannover, Germany, 3 March 1093. H1e01a,lt"hStHyarzeanred/sstoyfreBnuetaodxiiednee- aRnesduSlttysroenfea,niHemlaslinckair,cFiinnolgaenndi,ci2t1y sAtpurdiiles1"9,93I.nternational Symposium on M10i2c,hig"TahneSItnaitpeacUtniovferTsoixtiyc,it3yJSutnuedi1e9s93i.n the Regulatory Process", Dept. of Toxicology Seminar Series, 7 1190935.."The Toxicopatbology of Inhaled Fibers", Department of Pathology, Michigan State University,3 June "104In.tern"aPteieornRalevSiyemwpionsiCaurmc,inAolgeexnaincdirtiya,BiVoAa,ss2a8ysJu-nUse1s6/9A3b.uses",Society of Toxicologic Pathologists 12th i1n0h5a.lMatciCoonnnSetluld,y EoEf,SiKzacm-sstepraurpa,teOd.,MMauns-smealdmaenV,itR.r,eoHuesstFeirbbeerrsy,inTF.Wi.s,chCehrev3a4l4ie/rN, RJa.tasn.d2T4htehvIenntaezr,naPt.ioCnharlonic Congress on Occupational Health, Nice, France, 30 October 1993. `1B0e6r.linM,cGCoenrnmealnly,,E9E -10InDveitceedmebxeprer1t99t3e.stimony before the German @ Ministry of the Environmerit on MMVF's. C10o7n.feMrceCnocnen,eUlnli,veLrEs.it"yFiobfeRroicnhdeuscteedrpPautlhmoloongayryinanedxpCerriitimceanltCaalraenUinmiatl,s.20PhDyescioelmobgeyra1n9d9C3e.ll Biology S1o0c8i.eMtcyCoofnnReelglu,laEtEo.ry"TTaolxci:cCoolongsyuamnedr PUhsaersmaancdolHoegayl,thBePtehresspdeac,tiMvDes,"3P1anJealnD-i1scFuesbsa1n9t,94In.ternational : *" `1m0a9d.eMFciCbroesn,nPlar,isE,E.Fr"aAncdev,an3tFaegbe.s1a9n9d4.limitsofin vivo screening tests", AssessmentofToxicity of Man- S1y1n0t.hMectCiocnVnietlrle,ouEsEFib"eIrnsh:alSactiieonntiSftiucdaiensd:PMuebtlhiocdPoolloicgyieIsssUusese.dCarnysdtaClurCriteyn,tVSAt,ud2i-e3s"M,aSrycmhp1o9s9i4u.m on o11f1.AnMicmCaolnnCearlcli,noEgEe.ni"cHiitsytoSrtiucdaileRs,eGvreiatofLatkheesBDiiosacsussasyiaonndGFruotuupreofDitrheectSioocnise"t,yDoefsiTgonsiacnoldoIgnitcerpretation Pathologists, Cincinnati, OH, 24 March 1994. B1a12l.timMocrCeo,nnMeDl.l,4EMEa.rPcahne1l99m5e.mber "Workshop on Data Needs for CancerRiskAsse:ssment o-f MTBE", O11v3e.rlMocaCdoninnetlhle,REaEt.L"unMga:xiRemluemvaTnocleerfaotreHduDmoasen vReirsskuAssLsuonsgsmBeunrtd.enM:ITAPTaotxhiocloolgoigsytsSPyomipnotsioufmV,ieCwa"m,bPrairdtigcel,e MA, 29-30 March 1995. 114. "Dose Selection in Inhalation Studies", U.S. EPA Workshop,ChispilHill, NC, 8-10 May 1995. 115. "US. EPA Science Advisory Board Dioxin Reassessment Review", Herdon, VA, 15-16 May 1995. 111969.5."FIFRA SAP Reviess, Chairman, Aquatic Risk Assessment and Mitigation, Crystal City, VA, 17 July T1o17l.er"aEteUdRODoTsOeN"-,SPOraTguDeE,BCAhTeEc"hDRoespeubSleitct,in2g0fAoruCgar1c9i9n5geannicdiAtynaShteuidime,sCSAho1u2ldMbaercBhas1e9d96o.n the Maximum F1i17b.resReisnuRlotdseonftsL"i,feS-ytimmpeosInihuamlaotnionthSe tHueadlithofEfGfleacstss, oMfinFeirbarlouasnMdatSelraigaWloso(lesxcalnuddiRnegfarsabcetsotroys)CeUrsaemdicin Indusiry,Sydney, Australia, 30-31 Octobe, 1995. A11s8s.es"sTmheentR,odAeunsttiBni,oTaXs,sa4y DiencPeermsbpeercti1v0e9"6,. 101h International Conference on Carcinogenesis & Risk 72 + o1f19c,hrMycsCootninleelaln,dEaE.m,osMiitlleear,sbWe.s,tHoessitnerhbaemrsgt,eTrWs.a,ftTehreivnehnaalzat,iPo.n:anIdntAertiemnr,eCs.ulAts.cSoomcpiaertiysoofnToofxitchoelocfgfyects Annual Meeting, Cincinnati, OH, 1897. } D1.2C0.. M3AcpCroinnle1l9l9,7E. E Selecting Doses for Chronic Rodent B. ioassys. Brookings Institution. Washington, V1i2r1g.inMiac,C2o8nAnpreillE,lE,1.09R7e.gulatory Toxicology: lecture for "Principlesof Pharmacology', Medical Colleg3e of JT1hu22yn.reoMi1cd9C9lF7au.innc,tiMo.n:anThdyMrcoCiodnnHeilslo,paEtEh.ol"oWgoyraknsdhoSperonumScHroerenmionngeMAentahloydsissf"oDruEknedoUcnriivenresDitiys,rDuuprthoarmi,n NthCe, 24 A1l2e3s.aMncdrCioan,neVlAl,1E6EA.prUiplda1t99e8o.n the 10X Childrens Safety Factor. Pesticide Program Dialogue Comems ittee, . 2 S`1eH24pu.tmeaMmncbRCeerosnp1i9nr9ea3tl.oElrEy,.DCiasenacseers.anLdovNeolna-cCeaRnecseprirRaetsoproynRseesseatrocIhnhIanlsetidt'Fuitbeerssy,imVpaolsiiduistyno,fSaAnntiamFael, NMMo,dd2s0 for ~~ i * "1I2n5t.ernMactCioonnnaellSl,ymEpEo.sAiSucmieonncePabratiscelde TPoaxriacdoilgogmy.foMratahestClraisscihTfithce,atNieontohfeSrlyanntdhse.t1i3c-V1i5trOecotuosbFeirb1er9s9.9.7% `1E2x6p.erMicmCeonntnaellPl,atEhEo.loSgiymiBlraarintcihe,sNaantdioDniaslsiImnisltairtiuttieesofofEMnevsiortonhmeelnitoamlasHeIanldtuhcSecdibeyncAessb(eNsIHt)o,sRaTnP,d NSVCA.402.7 October 1999. ; . D1e27f.enMsceCoRnenseelalr,chEEI.nsAtiCtuotmep'sar2i0soAnnonfuaAlsbAessbteosstoasndMeSdiimciianneVMiercutsin4g0,ILnadsuVceegdaMs,esNoVt.h1l2ioNmoavseminbeArni1m6a0l9s.. I1n28t.ernMactCioonnnaellClo,nEgEr.esAsScoinenOccecu-pbaatsieodnAaplpHreoalatchh, tSointghaepColraes,si3f0icAautgiounsotf2S0y0n0t.hetic Vitreous Fibers. 26 210290.1MacnCdonNnaetlilo,naElE.InFsotiottutaenodfMEonuvtihroDnimseenatsae:l AHeRaeltvhieSwciLeenscieosn,s,NINHo,r6thJuCanreo2l0in0a1,State University, April, ' T21o34x0Ji.ucMnocleCoo2gn0yn0Pe1rl.lo,grEaEm. ABinoiamsaslayCRarnccseulrfSs.tudIinsetsitoufteSoodfiFuomodNitTreicthen:oHliosgtiosrticsaalnRneuvailemweaetnidnRge,cNeentwNOartlieoannasl, LA, M1e3d1.icMicnCeonMneeetliln,gE,EP.hoAcnniimxa,lATZ.est2iNngovaenmdbCehrry2s0o0t1il.e. Defense Rescarh Institute's 22nd Annual Asbestos R1e3s2.eaMrccChonTnreialnlg,lEeEP.erAkn,tNhCr.ax1i4nNSoovuetmhbAefrric2a0.01N.ational Institute of Environmental Health Sciences, N1o33v.emMcbCeornn2e0l0l1, EE. Anthrax in South Africa. College of Veterinary Medicine, NCSU, Raleigh, NC. 17 73 P1u3b4l.icMcPCoolnicnye.llN,ewE.EY.or"TkhAecVaadleuemyooffHuMemdainciTnees.tiNnYgC,ofNPYe.st2i7ciFdeesb.r"uaPresyt2ic0i0d2e.Testing in Humans: Ethics and * "13In5t.ensMicvCeoWnonrekls,hoEpE.. "NHourmtahnCaDraotlainina SRtsatkeAUsnsievesrssmietnyt,"9,ACuprrre2n0t0T2o.pics in Pesticide To'xicology: An 11316%.NMocrCtohnnAemlelr,iEc.aE.n I"SScSiXeMneceetainndg,Po2l5itOiccstoibneHru2m0a02n.Testing of Pesticides", Pesticides in the Molecular Age. FE1fi3fb7ee.crtMLsce?C"nogntAnhTe.lSlDN,ReEwEEx.Ypoe"rrHkt,oPwNaYnd.eol2A6on.ni3m0HaelOa/cltEtoxhbpEeefrrfie2mc0te0sn0to.fDAastbaeAstuogsmeanntd SoyunrthUentdiecrsFitbaenrdsi(nSgVoFf: THhuemIannflHueetnlctehof T1o3x8i.cMitcyCRoensneealrlchEEw.it"hThHeuVmaalnueRoefseHaurcmhanParTteisctiipnagn.t"s.NWRaCs/hNiAngStoCno,mmDiCt.te19eoMnatrhceh 2Us0e0o3fThird Pasty Pt1ao3r9Et.vicaMllceuCsaotAnesnseColaclri,caitEneEod.gew"niIitnchgePTsoattcieoonnntiiSattleu."dainIednstteorhfneaAAtsidbojenasactleonSstyamDnpudolusNtoihnu-mCAosombnpeltsehtxeo.sHePaalrtthicHleaszianrEdxEpvearliumaetnitoanloAf nFiibrmoausls,' 21100400A.3s.bMecsCtoonsneFliblerEsE.(A"nIinmfallueSntcuedoiefsF)i"beArsbTeypset,osSiMzeecahnadniEsxmpsoosufrTeioxictihteyCWaonrckesrhoapn,d CNhoinc-acgaon,ceILr. R1e2s-p13onJsuene 74