Document No3D9QyQJQMmBVdbvjnqVo5E
Su&asary of the Experiment Concerned with the Inhalation of Lead
; v. 1
Curing' 1060 , - ; ' .> ' " ...
Too .ieuci oxioe inhalation study., with Mr,
the
subject, is bci.ih: conducted in tLe scXi.'iO c.L.'.iiil?'r and under the s&so
conditions as those maintained la the first two studies during 1350 to
1954 when and were subjects.
Finely divided lean oxide C'ld&d 'dsqui oxide, FogC-g) Is. produced
by burning a restore .of propane* air and tetraethyl lead.' The concentration--'
of lead in the atmosphere is kept at 0.150 ssilligrasis per. cubic weter of air
and th iiverage 3ie of the- particles of lead oxide; is 0,05 raierons.
of the pax'ficaiato siaferxax in the avisiOOphere *.i the.
chamber re eollooted with a n .electrostatic precipitator for one Lour eut
of each -four hours "that the subject is in the chamber. The sample are
analysed by the dithissone method used routinely in this laboratory.
!
Once during each 'week a test is stade to determine the .amount
of load that is retained by the subject. This test consists of having, the.
subject breathe through a ask that lias two valves,, one that allows air to
enter and he- inhaled,and' the.'other allow, the exhaled air to escape. This :
exhaled air passes through an electrostatic precipitator tub into a Douglas
bag, after which'the total volume of the expired air can be measured. These
samples are always taken in parallel with a sample of 'the. atmosphere 'frost, the
chamber. The degree of retention of lead in the lung, in percentage of that
inhaled, is then calculated by means 'of the following formulai '
%., .
,'
.
'Fer cent Bet. s lead cone, in chamber - lead cone, in exhaled air x 100
lead cose, in chamber
As in the past, the following samples obtained fro the subject are
-.
' ,'
~,3> _
..
l
aaaly&S. .
..
X. C oncentration o t loes in haajcap (d a ily }
: .
.2. , t^ n d;O E j;slectsostatl.e'!;prsipit&torr.eurii^v csb a la t o n (w eek ly )
3. Food una l i p i d s ( d a lly )
/' , 4. Urine /(d a lly ).' .
,
. : . . 3. Feeea.. (d a lly )
'.
......
' S. Blood (wealtly)
''' '
Tbia ,aperia^4..difrf_ i r o s 'pg^liKia
allowing' '^aysi \ ' 1 .. '
...
:'
. . . X. th u lilo c t.s p d vt& re'differat. t lo e . f j e r l o e s ` <'.*'p
i n tbe caaiser,
8r and 10 hours. fhe iour-Iiour periods start, at
3.So a.s. or 2.30 p, m* .in a prearranged order'aad alternate'sltfa.t:
S bear period. 'Tsa-haur periods ooear evef fr ecfo*. 12s-'trjb4ec&
. ' f
'
'
'
pends c a i y 'vmii 'days- (Monday ttm sugh F riday) in th chamber.. . ' . ''
' \ '2. -Biooa samples re taken rea th e su b je c t ;*mc@ every s i .
ays in...order t o vary tm*. d a y .o f th e & 5 sM6. eh'blood sam p le-la
tal:en.
. '
3 . A ll O ats'o b ta in ed i r o s th e -s t r e e t ar'placed' oa punch cards', and processed by the Biometric iSepariisont. .
X 0004423